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InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry & Molecular Biology
DivisionBiochemistry & Molecular Biology
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    R01GM082837     (GOLDING, IDO)Dec 1, 2007 - Jul 31, 2021
    Gene Regulation in Phage Lambda: A Real-Time Study with Single-Event Resolution
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Golding I. Infection by bacteriophage lambda: an evolving paradigm for cellular individuality. Curr Opin Microbiol. 2018 06; 43:9-13. PMID: 29107897.
      View in: PubMed
    2. Sivaramakrishnan P, Sepúlveda LA, Halliday JA, Liu J, Núñez MAB, Golding I, Rosenberg SM, Herman C. The transcription fidelity factor GreA impedes DNA break repair. Nature. 2017 10 12; 550(7675):214-218. PMID: 28976965.
      View in: PubMed
    3. Xu H, Skinner SO, Sokac AM, Golding I. Stochastic Kinetics of Nascent RNA. Phys Rev Lett. 2016 Sep 16; 117(12). PMID: 27667861.
      View in: PubMed
    4. Golding I. Single-Cell Studies of Phage ?: Hidden Treasures Under Occam's Rug. Annu Rev Virol. 2016 09 29; 3(1):453-472. PMID: 27482899.
      View in: PubMed
    5. Figard L, Wang M, Zheng L, Golding I, Sokac AM. Membrane Supply and Demand Regulates F-Actin in a Cell Surface Reservoir. Dev Cell. 2016 05 09; 37(3):267-78. PMID: 27165556.
      View in: PubMed
    6. Sepúlveda LA, Xu H, Zhang J, Wang M, Golding I. Measurement of gene regulation in individual cells reveals rapid switching between promoter states. Science. 2016 Mar 11; 351(6278):1218-22. PMID: 26965629; PMCID: PMC4806797.
    7. Skinner SO, Xu H, Nagarkar-Jaiswal S, Freire PR, Zwaka TP, Golding I. Single-cell analysis of transcription kinetics across the cell cycle. Elife. 2016 Jan 29; 5:e12175. PMID: 26824388; PMCID: PMC4801054.
    8. Hsu TY, Simon LM, Neill NJ, Marcotte R, Sayad A, Bland CS, Echeverria GV, Sun T, Kurley SJ, Tyagi S, Karlin KL, Dominguez-Vidaña R, Hartman JD, Renwick A, Scorsone K, Bernardi RJ, Skinner SO, Jain A, Orellana M, Lagisetti C, Golding I, Jung SY, Neilson JR, Zhang XH, Cooper TA, Webb TR, Neel BG, Shaw CA, Westbrook TF. The spliceosome is a therapeutic vulnerability in MYC-driven cancer. Nature. 2015 Sep 17; 525(7569):384-8. PMID: 26331541.
      View in: PubMed
    9. Skinner SO, Sepúlveda LA, Xu H, Golding I. Corrigendum: Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization. Nat Protoc. 2015 Sep; 10(9):1457. PMID: 26313481.
      View in: PubMed
    10. Satory D, Gordon AJ, Wang M, Halliday JA, Golding I, Herman C. DksA involvement in transcription fidelity buffers stochastic epigenetic change. Nucleic Acids Res. 2015 Dec 02; 43(21):10190-9. PMID: 26304546; PMCID: PMC4666387.
    11. Xu H, Sepúlveda LA, Figard L, Sokac AM, Golding I. Combining protein and mRNA quantification to decipher transcriptional regulation. Nat Methods. 2015 Aug; 12(8):739-42. PMID: 26098021; PMCID: PMC4521975.
    12. Fei J, Singh D, Zhang Q, Park S, Balasubramanian D, Golding I, Vanderpool CK, Ha T. RNA biochemistry. Determination of in vivo target search kinetics of regulatory noncoding RNA. Science. 2015 Mar 20; 347(6228):1371-4. PMID: 25792329; PMCID: PMC4410144.
    13. Gordon AJ, Satory D, Wang M, Halliday JA, Golding I, Herman C. Removal of 8-oxo-GTP by MutT hydrolase is not a major contributor to transcriptional fidelity. Nucleic Acids Res. 2014 Oct 29; 42(19):12015-26. PMID: 25294823; PMCID: PMC4231768.
    14. Koirala S, Mears P, Sim M, Golding I, Chemla YR, Aldridge PD, Rao CV. A nutrient-tunable bistable switch controls motility in Salmonella enterica serovar Typhimurium. MBio. 2014 Aug 26; 5(5):e01611-14. PMID: 25161191; PMCID: PMC4173784.
    15. Bednarz M, Halliday JA, Herman C, Golding I. Revisiting bistability in the lysis/lysogeny circuit of bacteriophage lambda. PLoS One. 2014; 9(6):e100876. PMID: 24963924.
      View in: PubMed
    16. Mears PJ, Koirala S, Rao CV, Golding I, Chemla YR. Escherichia coli swimming is robust against variations in flagellar number. Elife. 2014 Feb 11; 3:e01916. PMID: 24520165; PMCID: PMC3917375.
    17. Sanchez A, Golding I. Genetic determinants and cellular constraints in noisy gene expression. Science. 2013 Dec 06; 342(6163):1188-93. PMID: 24311680; PMCID: PMC4045091.
    18. Figard L, Xu H, Garcia HG, Golding I, Sokac AM. The plasma membrane flattens out to fuel cell-surface growth during Drosophila cellularization. Dev Cell. 2013 Dec 23; 27(6):648-55. PMID: 24316147; PMCID: PMC3888437.
    19. Zheng L, Sepúlveda LA, Lua RC, Lichtarge O, Golding I, Sokac AM. The maternal-to-zygotic transition targets actin to promote robustness during morphogenesis. PLoS Genet. 2013 Nov; 9(11):e1003901. PMID: 24244181; PMCID: PMC3820746.
    20. Skinner SO, Sepúlveda LA, Xu H, Golding I. Measuring mRNA copy number in individual Escherichia coli cells using single-molecule fluorescent in situ hybridization. Nat Protoc. 2013 Jun; 8(6):1100-13. PMID: 23680982; PMCID: PMC4029592.
    21. Min TL, Mears PJ, Golding I, Chemla YR. Chemotactic adaptation kinetics of individual Escherichia coli cells. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9869-74. PMID: 22679285; PMCID: PMC3382544.
    22. Kessler JD, Kahle KT, Sun T, Meerbrey KL, Schlabach MR, Schmitt EM, Skinner SO, Xu Q, Li MZ, Hartman ZC, Rao M, Yu P, Dominguez-Vidana R, Liang AC, Solimini NL, Bernardi RJ, Yu B, Hsu T, Golding I, Luo J, Osborne CK, Creighton CJ, Hilsenbeck SG, Schiff R, Shaw CA, Elledge SJ, Westbrook TF. A SUMOylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis. Science. 2012 Jan 20; 335(6066):348-53. PMID: 22157079.
      View in: PubMed
    23. Zhang R, Rothenberg E, Fruhwirth G, Simonson PD, Ye F, Golding I, Ng T, Lopes W, Selvin PR. Two-photon 3D FIONA of individual quantum dots in an aqueous environment. Nano Lett. 2011 Oct 12; 11(10):4074-8. PMID: 21882883; PMCID: PMC3192306.
    24. Mir M, Wang Z, Shen Z, Bednarz M, Bashir R, Golding I, Prasanth SG, Popescu G. Optical measurement of cycle-dependent cell growth. Proc Natl Acad Sci U S A. 2011 Aug 09; 108(32):13124-9. PMID: 21788503; PMCID: PMC3156192.
    25. Rothenberg E, Sepúlveda LA, Skinner SO, Zeng L, Selvin PR, Golding I. Single-virus tracking reveals a spatial receptor-dependent search mechanism. Biophys J. 2011 Jun 22; 100(12):2875-82. PMID: 21689520; PMCID: PMC3123979.
    26. So LH, Ghosh A, Zong C, Sepúlveda LA, Segev R, Golding I. General properties of transcriptional time series in Escherichia coli. Nat Genet. 2011 Jun; 43(6):554-60. PMID: 21532574; PMCID: PMC3102781.
    27. Golding I. Decision making in living cells: lessons from a simple system. Annu Rev Biophys. 2011; 40:63-80. PMID: 21545284; PMCID: PMC4465489.
    28. Zong C, So LH, Sepúlveda LA, Skinner SO, Golding I. Lysogen stability is determined by the frequency of activity bursts from the fate-determining gene. Mol Syst Biol. 2010 Nov 30; 6:440. PMID: 21119634; PMCID: PMC3010116.
    29. Saini S, Koirala S, Floess E, Mears PJ, Chemla YR, Golding I, Aldridge C, Aldridge PD, Rao CV. FliZ induces a kinetic switch in flagellar gene expression. J Bacteriol. 2010 Dec; 192(24):6477-81. PMID: 20935096; PMCID: PMC3008537.
    30. Zeng L, Skinner SO, Zong C, Sippy J, Feiss M, Golding I. Decision making at a subcellular level determines the outcome of bacteriophage infection. Cell. 2010 May 14; 141(4):682-91. PMID: 20478257; PMCID: PMC2873970.
    31. Min TL, Mears PJ, Chubiz LM, Rao CV, Golding I, Chemla YR. High-resolution, long-term characterization of bacterial motility using optical tweezers. Nat Methods. 2009 Nov; 6(11):831-5. PMID: 19801991; PMCID: PMC2784139.
    32. Chia N, Golding I, Goldenfeld N. Lambda-prophage induction modeled as a cooperative failure mode of lytic repression. Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Sep; 80(3 Pt 1):030901. PMID: 19905052; PMCID: PMC4038166.
    33. Wang Y, Guo L, Golding I, Cox EC, Ong NP. Quantitative transcription factor binding kinetics at the single-molecule level. Biophys J. 2009 Jan; 96(2):609-20. PMID: 19167308; PMCID: PMC2716481.
    34. Golding I, Cox EC. Chapter 8: Spatiotemporal dynamics in bacterial cells: real-time studies with single-event resolution. Methods Cell Biol. 2008; 89:223-51. PMID: 19118677.
      View in: PubMed
    35. Golding I, Cox EC. Eukaryotic transcription: what does it mean for a gene to be 'on'? Curr Biol. 2006 May 23; 16(10):R371-3. PMID: 16713947.
      View in: PubMed
    36. Golding I, Cox EC. Physical nature of bacterial cytoplasm. Phys Rev Lett. 2006 Mar 10; 96(9):098102. PMID: 16606319.
      View in: PubMed
    37. Golding I, Cox EC. Protein synthesis molecule by molecule. Genome Biol. 2006; 7(6):221. PMID: 16938897; PMCID: PMC1779537.
    38. Golding I, Paulsson J, Zawilski SM, Cox EC. Real-time kinetics of gene activity in individual bacteria. Cell. 2005 Dec 16; 123(6):1025-36. PMID: 16360033.
      View in: PubMed
    39. Wang YM, Tegenfeldt JO, Reisner W, Riehn R, Guan XJ, Guo L, Golding I, Cox EC, Sturm J, Austin RH. Single-molecule studies of repressor-DNA interactions show long-range interactions. Proc Natl Acad Sci U S A. 2005 Jul 12; 102(28):9796-801. PMID: 15994229; PMCID: PMC1168954.
    40. Chen Y, Golding I, Sawai S, Guo L, Cox EC. Population fitness and the regulation of Escherichia coli genes by bacterial viruses. PLoS Biol. 2005 Jul; 3(7):e229. PMID: 15984911; PMCID: PMC1151598.
    41. Golding I, Cox EC. RNA dynamics in live Escherichia coli cells. Proc Natl Acad Sci U S A. 2004 Aug 03; 101(31):11310-5. PMID: 15277674; PMCID: PMC509199.
    42. Nevo U, Golding I, Neumann AU, Schwartz M, Akselrod S. Autoimmunity as an immune defense against degenerative processes: a primary mathematical model illustrating the bright side of autoimmunity. J Theor Biol. 2004 Apr 21; 227(4):583-92. PMID: 15038992.
      View in: PubMed
    43. Nevo U, Kipnis J, Golding I, Shaked I, Neumann A, Akselrod S, Schwartz M. Autoimmunity as a special case of immunity: removing threats from within. Trends Mol Med. 2003 Mar; 9(3):88-93. PMID: 12657429.
      View in: PubMed
    44. Shefi O, Golding I, Segev R, Ben-Jacob E, Ayali A. Morphological characterization of in vitro neuronal networks. Phys Rev E Stat Nonlin Soft Matter Phys. 2002 Aug; 66(2 Pt 1):021905. PMID: 12241212.
      View in: PubMed
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