YONGJIE YANG

TitleInstructor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 BATES
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    1. Conde KM, Wong H, Fang S, Li Y, Yu M, Deng Y, Liu Q, Fang X, Wang M, Shi Y, Ginnard OZ, Yang Y, Tu L, Liu H, Liu H, Yin N, Bean JC, Han J, Burt ME, Jossy SV, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. Serotonin neurons integrate GABA and dopamine inputs to regulate meal initiation. Metabolism. 2024 Dec 10; 163:156099. PMID: 39667432.
      Citations:    Fields:    
    2. Yu M, Yin N, Feng B, Gao P, Yu K, Liu H, Liu H, Li Y, Ginnard OZ, Conde KM, Wang M, Fang X, Tu L, Bean JC, Liu Q, Deng Y, Yang Y, Han J, Jossy SV, Burt ML, Wong HZ, Yang Y, Arenkiel BR, He Y, Guo S, Gourdy P, Arnal JF, Lenfant F, Wang Z, Wang C, He Y, Xu Y. Identification of an ionic mechanism for ERa-mediated rapid excitation in neurons. Sci Adv. 2024 Oct 04; 10(40):eadp0696. PMID: 39356770; PMCID: PMC11446276.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Liu H, Bean JC, Li Y, Yu M, Ginnard OZ, Conde KM, Wang M, Fang X, Liu H, Tu L, Yin N, Han J, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. Distinct basal forebrain-originated neural circuits promote homoeostatic feeding and suppress hedonic feeding in male mice. Nat Metab. 2024 Sep; 6(9):1775-1790. PMID: 39112722.
      Citations:    Fields:    Translation:AnimalsCells
    4. Liu H, Qu N, Gonzalez NV, Palma MA, Chen H, Xiong J, Choubey A, Li Y, Li X, Yu M, Liu H, Tu L, Zhang N, Yin N, Conde KM, Wang M, Bean JC, Han J, Scarcelli NA, Yang Y, Saito K, Cui H, Tong Q, Sun Z, Wang C, Cai X, Lu L, He Y, Xu Y, Liu H, Qu N, Gonzalez NV, Palma MA, Chen H, Xiong J, Choubey A, Li Y, Li X, Yu M, Liu H, Tu L, Zhang N, Yin N, Conde KM, Wang M, Bean JC, Han J, Scarcelli NA, Yang Y, Saito K, Cui H, Tong Q, Sun Z, Wang C, Cai X, Lu L, He Y, Xu Y. A Light-Responsive Neural Circuit Suppresses Feeding. J Neurosci. 2024 Jul 24; 44(30). PMID: 38897723; PMCID: PMC11270527.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Li Y, Cacciottolo TM, Yin N, He Y, Liu H, Liu H, Yang Y, Henning E, Keogh JM, Lawler K, Mendes de Oliveira E, Gardner EJ, Kentistou KA, Laouris P, Bounds R, Ong KK, Perry JRB, Barroso I, Tu L, Bean JC, Yu M, Conde KM, Wang M, Ginnard O, Fang X, Tong L, Han J, Darwich T, Williams KW, Yang Y, Wang C, Joss S, Firth HV, Xu Y, Farooqi IS. Loss of transient receptor potential channel 5 causes obesity and postpartum depression. Cell. 2024 Aug 08; 187(16):4176-4192.e17. PMID: 38959890.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    6. Liu H, He Y, Liu H, Brouwers B, Yin N, Lawler K, Keogh JM, Henning E, Lee DK, Yu M, Tu L, Zhang N, Conde KM, Han J, Yan Z, Scarcelli NA, Liao L, Xu J, Tong Q, Zheng H, Sun Z, Yang Y, Wang C, He Y, Farooqi IS, Xu Y. Neural circuits expressing the serotonin 2C receptor regulate memory in mice and humans. Sci Adv. 2024 Jun 28; 10(26):eadl2675. PMID: 38941473; PMCID: PMC11212768.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Conde KM, Wong H, Fang S, Li Y, Yu M, Deng Y, Liu Q, Fang X, Wang M, Shi Y, Ginnard OZ, Yang Y, Tu L, Liu H, Liu H, Yin N, Bean JC, Han J, Burt ME, Jossy SV, Yang Y, Tong Q, Arenkiel BR, Wang C, He Y, Xu Y. 5-HT Neurons Integrate GABA and Dopamine Inputs to Regulate Meal Initiation. bioRxiv. 2024 Apr 29. PMID: 38746314; PMCID: PMC11092489.
      Citations:    
    8. Tu L, Bean JC, He Y, Liu H, Yu M, Liu H, Zhang N, Yin N, Han J, Scarcelli NA, Conde KM, Wang M, Li Y, Feng B, Gao P, Cai ZL, Fukuda M, Xue M, Tong Q, Yang Y, Liao L, Xu J, Wang C, He Y, Xu Y. Anoctamin 4 channel currents activate glucose-inhibited neurons in the mouse ventromedial hypothalamus during hypoglycemia. J Clin Invest. 2023 07 17; 133(14). PMID: 37261917; PMCID: PMC10348766.
      Citations:    Fields:    Translation:AnimalsCells
    9. Wang M, Yang Y, Xu Y. Brain nuclear receptors and cardiovascular function. Cell Biosci. 2023 Jan 20; 13(1):14. PMID: 36670468; PMCID: PMC9854230.
      Citations: 1     
    10. He Y, Brouwers B, Liu H, Liu H, Lawler K, Mendes de Oliveira E, Lee DK, Yang Y, Cox AR, Keogh JM, Henning E, Bounds R, Perdikari A, Ayinampudi V, Wang C, Yu M, Tu L, Zhang N, Yin N, Han J, Scarcelli NA, Yan Z, Conde KM, Potts C, Bean JC, Wang M, Hartig SM, Liao L, Xu J, Barroso I, Mokrosinski J, Xu Y, Sadaf Farooqi I. Human loss-of-function variants in the serotonin 2C receptor associated with obesity and maladaptive behavior. Nat Med. 2022 12; 28(12):2537-2546. PMID: 36536256; PMCID: PMC9800280.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Yu M, Bean JC, Liu H, He Y, Yang Y, Cai X, Yu K, Pei Z, Liu H, Tu L, Conde KM, Wang M, Li Y, Yin N, Zhang N, Han J, Scarcelli NA, Xu P, He Y, Xu Y, Wang C. SK3 in POMC neurons plays a sexually dimorphic role in energy and glucose homeostasis. Cell Biosci. 2022 Oct 09; 12(1):170. PMID: 36210455; PMCID: PMC9549684.
      Citations: 2     
    12. Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Liang C, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. Publisher Correction: A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nat Neurosci. 2022 Jul; 25(7):976. PMID: 35729403.
      Citations:    Fields:    
    13. Cai X, Liu H, Feng B, Yu M, He Y, Liu H, Liang C, Yang Y, Tu L, Zhang N, Wang L, Yin N, Han J, Yan Z, Wang C, Xu P, Wu Q, Tong Q, He Y, Xu Y. A D2 to D1 shift in dopaminergic inputs to midbrain 5-HT neurons causes anorexia in mice. Nat Neurosci. 2022 05; 25(5):646-658. PMID: 35501380; PMCID: PMC9926508.
      Citations:    Fields:    Translation:AnimalsCells
    14. Yang Y, He Y, Liu H, Zhou W, Wang C, Xu P, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Fukuda M, Tong Q, Xu J, Sun Z, O'Malley BW, Xu Y. Hypothalamic steroid receptor coactivator-2 regulates adaptations to fasting and overnutrition. Cell Rep. 2021 12 07; 37(10):110075. PMID: 34879284; PMCID: PMC8715676.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. Zhang N, Yan Z, Liu H, Yu M, He Y, Liu H, Liang C, Tu L, Wang L, Yin N, Han J, Scarcelli N, Yang Y, Wang C, Zeng T, Chen LL, Xu Y. Hypothalamic Perineuronal Nets Are Regulated by Sex and Dietary Interventions. Front Physiol. 2021; 12:714104. PMID: 34393830; PMCID: PMC8355523.
      Citations: 2     
    16. He Y, Cai X, Liu H, Conde KM, Xu P, Li Y, Wang C, Yu M, He Y, Liu H, Liang C, Yang T, Yang Y, Yu K, Wang J, Zheng R, Liu F, Sun Z, Heisler L, Wu Q, Tong Q, Zhu C, Shu G, Xu Y. 5-HT recruits distinct neurocircuits to inhibit hunger-driven and non-hunger-driven feeding. Mol Psychiatry. 2021 12; 26(12):7211-7224. PMID: 34290371; PMCID: PMC8776930.
      Citations: 3     Fields:    Translation:Cells
    17. He Y, Liu H, Yin N, Yang Y, Wang C, Yu M, Liu H, Liang C, Wang J, Tu L, Zhang N, Wang L, He Y, Fukuda M, Wu Q, Sun Z, Tong Q, Xu Y. Barbadin Potentiates Long-Term Effects of Lorcaserin on POMC Neurons and Weight Loss. J Neurosci. 2021 06 30; 41(26):5734-5746. PMID: 34031163; PMCID: PMC8244968.
      Citations: 1     Fields:    Translation:AnimalsCells
    18. Wang C, Zhou W, He Y, Yang T, Xu P, Yang Y, Cai X, Wang J, Liu H, Yu M, Liang C, Yang T, Liu H, Fukuda M, Tong Q, Wu Q, Sun Z, He Y, Xu Y. AgRP neurons trigger long-term potentiation and facilitate food seeking. Transl Psychiatry. 2021 01 05; 11(1):11. PMID: 33414382; PMCID: PMC7791100.
      Citations: 5     Fields:    Translation:AnimalsCells
    19. Yang Y, Xu Y. The central melanocortin system and human obesity. J Mol Cell Biol. 2020 10 01; 12(10):785-797. PMID: 32976556; PMCID: PMC7816681.
      Citations: 5     Fields:    Translation:HumansAnimals
    20. Yu K, He Y, Hyseni I, Pei Z, Yang Y, Xu P, Cai X, Liu H, Qu N, Liu H, He Y, Yu M, Liang C, Yang T, Wang J, Xu Y, Wang C, Gourdy P, Arnal JF, Lenfant F. 17?-estradiol promotes acute refeeding in hungry mice via membrane-initiated ERa signaling. Mol Metab. 2020 12; 42:101053. PMID: 32712433; PMCID: PMC7484552.
      Citations: 8     Fields:    Translation:AnimalsCells
    21. He Y, Xu P, Wang C, Xia Y, Yu M, Yang Y, Yu K, Cai X, Qu N, Saito K, Wang J, Hyseni I, Robertson M, Piyarathna B, Gao M, Khan SA, Liu F, Chen R, Coarfa C, Zhao Z, Tong Q, Sun Z, Xu Y. Estrogen receptor-a expressing neurons in the ventrolateral VMH regulate glucose balance. Nat Commun. 2020 05 01; 11(1):2165. PMID: 32358493; PMCID: PMC7195451.
      Citations: 18     Fields:    Translation:AnimalsCells
    22. Qu N, He Y, Wang C, Xu P, Yang Y, Cai X, Liu H, Yu K, Pei Z, Hyseni I, Sun Z, Fukuda M, Li Y, Tian Q, Xu Y. A POMC-originated circuit regulates stress-induced hypophagia, depression, and anhedonia. Mol Psychiatry. 2020 05; 25(5):1006-1021. PMID: 31485012; PMCID: PMC7056580.
      Citations: 23     Fields:    Translation:Animals
    23. Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P, Saito K, Hinton A, Yan X, Keogh JM, Henning E, Banton MC, Hendricks AE, Bochukova EG, Mistry V, Lawler KL, Liao L, Xu J, O'Rahilly S, Tong Q, UK10K Consortium, O'Malley BW, Farooqi IS, Xu Y. Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis. Nat Commun. 2019 04 12; 10(1):1718. PMID: 30979869; PMCID: PMC6461669.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    24. Wang C, He Y, Xu P, Yang Y, Saito K, Xia Y, Yan X, Hinton A, Yan C, Ding H, Yu L, Shu G, Gupta R, Wu Q, Tong Q, Lagor WR, Flores ER, Xu Y. TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis. Nat Commun. 2018 04 18; 9(1):1544. PMID: 29670083; PMCID: PMC5906443.
      Citations: 28     Fields:    Translation:AnimalsCells
    25. Hinton AO, Yang Y, Quick AP, Xu P, Reddy CL, Yan X, Reynolds CL, Tong Q, Zhu L, Xu J, Wehrens XH, Xu Y, Reddy AK. SRC-1 Regulates Blood Pressure and Aortic Stiffness in Female Mice. PLoS One. 2016; 11(12):e0168644. PMID: 28006821; PMCID: PMC5179266.
      Citations: 3     Fields:    Translation:Animals
    26. Xu P, Zhu L, Saito K, Yang Y, Wang C, He Y, Yan X, Hyseni I, Tong Q, Xu Y. Melanocortin 4 receptor is not required for estrogenic regulations on energy homeostasis and reproduction. Metabolism. 2017 05; 70:152-159. PMID: 28403939; PMCID: PMC5407306.
      Citations: 3     Fields:    Translation:Animals
    27. He Y, Shu G, Yang Y, Xu P, Xia Y, Wang C, Saito K, Hinton A, Yan X, Liu C, Wu Q, Tong Q, Xu Y. A Small Potassium Current in AgRP/NPY Neurons Regulates Feeding Behavior and Energy Metabolism. Cell Rep. 2016 11 08; 17(7):1807-1818. PMID: 27829152; PMCID: PMC6248907.
      Citations: 10     Fields:    Translation:AnimalsCells
    28. Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A, Zhu L, Shu G, Myers MG, Wu Q, Tong Q, Heisler LK, Xu Y. Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biol Psychiatry. 2017 05 01; 81(9):737-747. PMID: 27516377; PMCID: PMC5148733.
      Citations: 37     Fields:    Translation:AnimalsCells
    29. Hinton AO, He Y, Xia Y, Xu P, Yang Y, Saito K, Wang C, Yan X, Shu G, Henderson A, Clegg DJ, Khan SA, Reynolds C, Wu Q, Tong Q, Xu Y. Estrogen Receptor-a in the Medial Amygdala Prevents Stress-Induced Elevations in Blood Pressure in Females. Hypertension. 2016 06; 67(6):1321-30. PMID: 27091896; PMCID: PMC4865414.
      Citations: 5     Fields:    Translation:Animals
    30. Saito K, He Y, Yang Y, Zhu L, Wang C, Xu P, Hinton AO, Yan X, Zhao J, Fukuda M, Tong Q, Clegg DJ, Xu Y. PI3K in the ventromedial hypothalamic nucleus mediates estrogenic actions on energy expenditure in female mice. Sci Rep. 2016 Mar 18; 6:23459. PMID: 26988598; PMCID: PMC4796901.
      Citations: 25     Fields:    Translation:Animals
    31. Saito K, He Y, Yan X, Yang Y, Wang C, Xu P, Hinton AO, Shu G, Yu L, Tong Q, Xu Y. Visualizing estrogen receptor-a-expressing neurons using a new ERa-ZsGreen reporter mouse line. Metabolism. 2016 Apr; 65(4):522-32. PMID: 26975544; PMCID: PMC4794642.
      Citations: 16     Fields:    Translation:AnimalsCells
    32. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425; PMCID: PMC4655219.
      Citations: 23     Fields:    Translation:AnimalsCells
    33. Yan C, He Y, Xu Y, Shu G, Wang C, Yang Y, Saito K, Xu P, Hinton AO, Yan X, Yu L, Wu Q, Tso P, Tong Q, Xu Y. Apolipoprotein A-IV Inhibits AgRP/NPY Neurons and Activates Pro-Opiomelanocortin Neurons in the Arcuate Nucleus. Neuroendocrinology. 2016; 103(5):476-488. PMID: 26337236; PMCID: PMC4767704.
      Citations: 11     Fields:    Translation:AnimalsCells
    34. Xu P, Cao X, He Y, Zhu L, Yang Y, Saito K, Wang C, Yan X, Hinton AO, Zou F, Ding H, Xia Y, Yan C, Shu G, Wu SP, Yang B, Feng Y, Clegg DJ, DeMarchi R, Khan SA, Tsai SY, DeMayo FJ, Wu Q, Tong Q, Xu Y. Estrogen receptor-a in medial amygdala neurons regulates body weight. J Clin Invest. 2015 Jul 01; 125(7):2861-76. PMID: 26098212; PMCID: PMC4563687.
      Citations: 53     Fields:    Translation:AnimalsCells
    35. Yan C, Yang Y, Saito K, Xu P, Wang C, Hinton AO, Yan X, Wu Q, Tong Q, Elmquist JK, Fukuda M, Xu Y. Meta-chlorophenylpiperazine enhances leptin sensitivity in diet-induced obese mice. Br J Pharmacol. 2015 Jul; 172(14):3510-21. PMID: 25817043; PMCID: PMC4507156.
      Citations: 5     Fields:    Translation:AnimalsCells
    36. Zhu L, Zou F, Yang Y, Xu P, Saito K, Othrell Hinton A, Yan X, Ding H, Wu Q, Fukuda M, Sun Z, Tong Q, Xu Y. Estrogens prevent metabolic dysfunctions induced by circadian disruptions in female mice. Endocrinology. 2015 Jun; 156(6):2114-23. PMID: 25807042; PMCID: PMC4430614.
      Citations: 18     Fields:    Translation:Animals
    37. Cao X, Xu P, Oyola MG, Xia Y, Yan X, Saito K, Zou F, Wang C, Yang Y, Hinton A, Yan C, Ding H, Zhu L, Yu L, Yang B, Feng Y, Clegg DJ, Khan S, DiMarchi R, Mani SK, Tong Q, Xu Y. Estrogens stimulate serotonin neurons to inhibit binge-like eating in mice. J Clin Invest. 2014 Oct; 124(10):4351-62. PMID: 25157819; PMCID: PMC4191033.
      Citations: 47     Fields:    Translation:AnimalsCells
    38. Pan JS, Huang L, Belousova T, Lu L, Yang Y, Reddel R, Chang A, Ju H, DiMattia G, Tong Q, Sheikh-Hamad D. Stanniocalcin-1 inhibits renal ischemia/reperfusion injury via an AMP-activated protein kinase-dependent pathway. J Am Soc Nephrol. 2015 Feb; 26(2):364-78. PMID: 25012175; PMCID: PMC4310644.
      Citations: 38     Fields:    Translation:AnimalsCells
    39. Yang Y, Xu P, Zou F, Yan X, Liao L, Xu J, O'Malley BW, Xu Y, Zhu L. Steroid receptor coactivator-1 mediates estrogenic actions to prevent body weight gain in female mice. Endocrinology. 2013 Jan; 154(1):150-8. PMID: 23211707; PMCID: PMC3529365.
      Citations: 28     Fields:    Translation:AnimalsCells
    40. Yang Y, Chen KY, Tong Q. Murine Sirt3 protein isoforms have variable half-lives. Gene. 2011 Nov 15; 488(1-2):46-51. PMID: 21840382; PMCID: PMC3185158.
      Citations: 8     Fields:    Translation:AnimalsCells
    41. Yang Y, Hubbard BP, Sinclair DA, Tong Q. Characterization of murine SIRT3 transcript variants and corresponding protein products. J Cell Biochem. 2010 Nov 01; 111(4):1051-8. PMID: 20677216; PMCID: PMC3558747.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    42. Yang Y, Cimen H, Han MJ, Shi T, Deng JH, Koc H, Palacios OM, Montier L, Bai Y, Tong Q, Koc EC. NAD+-dependent deacetylase SIRT3 regulates mitochondrial protein synthesis by deacetylation of the ribosomal protein MRPL10. J Biol Chem. 2010 Mar 05; 285(10):7417-29. PMID: 20042612; PMCID: PMC2844190.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
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