Fibroblast Growth Factor 2
"Fibroblast Growth Factor 2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A single-chain polypeptide growth factor that plays a significant role in the process of WOUND HEALING and is a potent inducer of PHYSIOLOGIC ANGIOGENESIS. Several different forms of the human protein exist ranging from 18-24 kDa in size due to the use of alternative start sites within the fgf-2 gene. It has a 55 percent amino acid residue identity to FIBROBLAST GROWTH FACTOR 1 and has potent heparin-binding activity. The growth factor is an extremely potent inducer of DNA synthesis in a variety of cell types from mesoderm and neuroectoderm lineages. It was originally named basic fibroblast growth factor based upon its chemical properties and to distinguish it from acidic fibroblast growth factor (FIBROBLAST GROWTH FACTOR 1).
| Descriptor ID |
D016222
|
| MeSH Number(s) |
D12.644.276.624.120 D12.776.467.624.120 D23.529.624.120
|
| Concept/Terms |
Fibroblast Growth Factor 2- Fibroblast Growth Factor 2
- Basic Fibroblast Growth Factor
- Class II Heparin-Binding Growth Factor
- Heparin-Binding Growth Factor Class II
- HBGF-2
- Prostatropin
- FGF-2
- FGF 2
- FGF2
- Fibroblast Growth Factor, Basic
- Fibroblast Growth Factor-2
- Cartilage-Derived Growth Factor
- Cartilage Derived Growth Factor
- Prostate Epithelial Cell Growth Factor
|
Below are MeSH descriptors whose meaning is more general than "Fibroblast Growth Factor 2".
Below are MeSH descriptors whose meaning is more specific than "Fibroblast Growth Factor 2".
This graph shows the total number of publications written about "Fibroblast Growth Factor 2" by people in this website by year, and whether "Fibroblast Growth Factor 2" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 2 | 2 | 4 |
| 1995 | 3 | 2 | 5 |
| 1996 | 1 | 1 | 2 |
| 1997 | 6 | 4 | 10 |
| 1998 | 5 | 0 | 5 |
| 1999 | 4 | 6 | 10 |
| 2000 | 4 | 10 | 14 |
| 2001 | 3 | 8 | 11 |
| 2002 | 2 | 14 | 16 |
| 2003 | 5 | 6 | 11 |
| 2004 | 6 | 8 | 14 |
| 2005 | 2 | 3 | 5 |
| 2006 | 1 | 7 | 8 |
| 2007 | 2 | 2 | 4 |
| 2008 | 4 | 3 | 7 |
| 2009 | 0 | 5 | 5 |
| 2010 | 0 | 2 | 2 |
| 2011 | 0 | 2 | 2 |
| 2012 | 0 | 1 | 1 |
| 2013 | 3 | 1 | 4 |
| 2014 | 1 | 2 | 3 |
| 2015 | 1 | 1 | 2 |
| 2017 | 0 | 2 | 2 |
| 2018 | 1 | 2 | 3 |
| 2019 | 1 | 0 | 1 |
| 2022 | 1 | 0 | 1 |
| 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Fibroblast Growth Factor 2" by people in Profiles.
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Comparison of Four Protocols for In Vitro Differentiation of Human Embryonic Stem Cells into Trophoblast Lineages by BMP4 and Dual Inhibition of Activin/Nodal and FGF2 Signaling. Reprod Sci. 2024 01; 31(1):173-189.
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Feeding role of mouse embryonic fibroblast cells is influenced by genetic background, cell passage and day of isolation. Zygote. 2022 Aug; 30(4):550-560.
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Enhancement of cell proliferation and motility of mammalian cells grown in co-culture with Pichia pastoris expressing recombinant human FGF-2. Protein Expr Purif. 2020 12; 176:105724.
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Perlecan domain I gradients establish stable biomimetic heparin binding growth factor gradients for cell migration in hydrogels. Acta Biomater. 2019 10 01; 97:385-398.
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Pigment Epithelium-Derived Factor and its Phosphomimetic Mutant Induce JNK-Dependent Apoptosis and P38-Mediated Migration Arrest. Cell Physiol Biochem. 2018; 49(2):512-529.
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FGF-2 is a driving force for chromosomal instability and a stromal factor associated with adverse clinico-pathological features in prostate cancer. Urol Oncol. 2018 08; 36(8):365.e15-365.e26.
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Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer. J Exp Med. 2018 03 05; 215(3):895-910.
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Tumor-associated B-cells induce tumor heterogeneity and therapy resistance. Nat Commun. 2017 09 19; 8(1):607.
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Infusion of Valproic Acid Into the Renal Medulla Activates Stem Cell Population and Attenuates Salt-Sensitive Hypertension in Dahl S Rats. Cell Physiol Biochem. 2017; 42(3):1264-1273.
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Novel multiple tyrosine kinase inhibitor ponatinib inhibits bFGF-activated signaling in neuroblastoma cells and suppresses neuroblastoma growth in vivo. Oncotarget. 2017 Jan 24; 8(4):5874-5884.