"Tankyrases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A group of telomere associated proteins that interact with TRF1 PROTEIN, contain ANKYRIN REPEATS and have poly(ADP-ribose) polymerase activity.
| Descriptor ID |
D038501
|
| MeSH Number(s) |
D08.811.913.400.725.115.690.840
|
| Concept/Terms |
Tankyrases- Tankyrases
- TRF-1 Interacting, Ankyrin-Related, ADP-Ribose Polymerases
|
Below are MeSH descriptors whose meaning is more general than "Tankyrases".
Below are MeSH descriptors whose meaning is more specific than "Tankyrases".
This graph shows the total number of publications written about "Tankyrases" by people in this website by year, and whether "Tankyrases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2013 | 1 | 0 | 1 |
| 2015 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
| 2019 | 1 | 0 | 1 |
| 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Tankyrases" by people in Profiles.
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Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease. BMC Genom Data. 2021 06 10; 22(1):20.
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Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 09 25; 10(1):4363.
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Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Rep. 2017 07 18; 20(3):737-749.
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Development and structural analysis of adenosine site binding tankyrase inhibitors. Bioorg Med Chem Lett. 2016 Jan 15; 26(2):328-333.
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Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Rep. 2015 Oct 20; 13(3):524-532.
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Discovery of potent and selective nonplanar tankyrase inhibiting nicotinamide mimics. Bioorg Med Chem. 2015 Aug 01; 23(15):4139-4149.
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Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes Dev. 2015 Jan 15; 29(2):157-70.
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para-Substituted 2-phenyl-3,4-dihydroquinazolin-4-ones as potent and selective tankyrase inhibitors. ChemMedChem. 2013 Dec; 8(12):1978-85.
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Discovery of tankyrase inhibiting flavones with increased potency and isoenzyme selectivity. J Med Chem. 2013 Oct 24; 56(20):7880-9.
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Structural basis and selectivity of tankyrase inhibition by a Wnt signaling inhibitor WIKI4. PLoS One. 2013; 8(6):e65404.