"Intercalating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
| Descriptor ID |
D007364
|
| MeSH Number(s) |
D27.720.470.410.360
|
| Concept/Terms |
Intercalating Agents- Intercalating Agents
- Agents, Intercalating
- Intercalating Ligands
- Ligands, Intercalating
- Intercalators
- Intercalative Compounds
- Compounds, Intercalative
|
Below are MeSH descriptors whose meaning is more general than "Intercalating Agents".
Below are MeSH descriptors whose meaning is more specific than "Intercalating Agents".
This graph shows the total number of publications written about "Intercalating Agents" by people in this website by year, and whether "Intercalating Agents" was a major or minor topic of these publications.
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Below are the most recent publications written about "Intercalating Agents" by people in Profiles.
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Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)]. Arch Biochem Biophys. 2002 May 01; 401(1):53-62.
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Influence of intervening mismatches on long-range guanine oxidation in DNA duplexes. J Am Chem Soc. 2001 Sep 12; 123(36):8649-56.
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Exploiting anthracycline scaffold for designing DNA-targeting agents. Methods Enzymol. 2001; 340:529-55.
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Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res. 1999 Sep 01; 27(17):3402-9.
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Ultratight DNA binding of a new bisintercalating anthracycline antibiotic. Biochemistry. 1998 Feb 17; 37(7):1743-53.
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Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy. Biochemistry. 1997 Jul 22; 36(29):8663-70.
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Structure of a DNA-bisdaunomycin complex. Biochemistry. 1997 May 20; 36(20):5940-6.
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Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein. EMBO J. 1997 Feb 03; 16(3):625-38.
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Structure-based design of a new bisintercalating anthracycline antibiotic. J Med Chem. 1997 Jan 31; 40(3):261-6.
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Comparison of DNA sequence selectivity of anthracycline antibiotics and their 3'-hydroxylated analogs. Chem Biol Interact. 1996 Mar 25; 100(2):165-76.