"Intercalating Agents" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Agents that are capable of inserting themselves between the successive bases in DNA, thus kinking, uncoiling or otherwise deforming it and therefore preventing its proper functioning. They are used in the study of DNA.
| Descriptor ID |
D007364
|
| MeSH Number(s) |
D27.720.470.410.360
|
| Concept/Terms |
Intercalating Agents- Intercalating Agents
- Agents, Intercalating
- Intercalating Ligands
- Ligands, Intercalating
- Intercalators
- Intercalative Compounds
- Compounds, Intercalative
|
Below are MeSH descriptors whose meaning is more general than "Intercalating Agents".
Below are MeSH descriptors whose meaning is more specific than "Intercalating Agents".
This graph shows the total number of publications written about "Intercalating Agents" by people in this website by year, and whether "Intercalating Agents" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 3 | 1 | 4 |
| 1998 | 1 | 1 | 2 |
| 1999 | 1 | 0 | 1 |
| 2001 | 0 | 2 | 2 |
| 2002 | 2 | 1 | 3 |
| 2003 | 1 | 0 | 1 |
| 2004 | 0 | 1 | 1 |
| 2005 | 1 | 0 | 1 |
| 2011 | 1 | 0 | 1 |
| 2013 | 1 | 0 | 1 |
| 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Intercalating Agents" by people in Profiles.
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ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light. Org Biomol Chem. 2019 02 13; 17(7):1827-1833.
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Hydrogen peroxide activated quinone methide precursors with enhanced DNA cross-linking capability and cytotoxicity towards cancer cells. Eur J Med Chem. 2017 Jun 16; 133:197-207.
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Electrochemical transduction of DNA hybridization at modified electrodes by using an electroactive pyridoacridone intercalator. Anal Bioanal Chem. 2014 Feb; 406(4):1163-72.
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Hydrogen peroxide inducible DNA cross-linking agents: targeted anticancer prodrugs. J Am Chem Soc. 2011 Dec 07; 133(48):19278-81.
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A new bisintercalating anthracycline with picomolar DNA binding affinity. J Med Chem. 2005 Dec 29; 48(26):8209-19.
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Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: effects of the bis-intercalator WP631 on growth and cell cycle of T-24 cells. Cytometry A. 2004 Feb; 57(2):113-9.
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New findings in the study on the intercalation of bisdaunorubicin and its monomeric analogues with naked and nucleus DNA. Chem Biol Interact. 2003 Jun 15; 145(3):349-58.
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Topoisomerase II antagonism and anticancer activity of coordinated derivatives of [RuCl(2)(C(6)H(6))(dmso)]. Arch Biochem Biophys. 2002 May 01; 401(1):53-62.
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Oxidative damage by ruthenium complexes containing the dipyridophenazine ligand or its derivatives: a focus on intercalation. Inorg Chem. 2002 Apr 08; 41(7):1966-74.
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Induction of G(2)/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes. Biochem Pharmacol. 2002 Apr 01; 63(7):1251-8.