Chagas Cardiomyopathy

"Chagas Cardiomyopathy" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information

Definition | Details | More General Concepts | Related Concepts | More Specific Concepts

A disease of the CARDIAC MUSCLE developed subsequent to the initial protozoan infection by TRYPANOSOMA CRUZI. After infection, less than 10% develop acute illness such as MYOCARDITIS (mostly in children). The disease then enters a latent phase without clinical symptoms until about 20 years later. Myocardial symptoms of advanced CHAGAS DISEASE include conduction defects (HEART BLOCK) and CARDIOMEGALY.

Descriptor ID	D002598
MeSH Number(s)	C03.752.300.900.200.190 C14.280.238.190
Concept/Terms	Chagas Cardiomyopathy Chagas Cardiomyopathy Trypanosomiasis, Cardiovascular Cardiovascular Trypanosomiasis Chagas' Cardiomyopathy Cardiomyopathy, Chagas' Cardiomyopathy, Chagas Myocarditis, Chagas Myocarditis, Chagas

Below are MeSH descriptors whose meaning is more general than "Chagas Cardiomyopathy".

Diseases [C]
Parasitic Diseases [C03]
Protozoan Infections [C03.752]
Euglenozoa Infections [C03.752.300]
Trypanosomiasis [C03.752.300.900]
Chagas Disease [C03.752.300.900.200]
Chagas Cardiomyopathy [C03.752.300.900.200.190]
Cardiovascular Diseases [C14]
Heart Diseases [C14.280]
Cardiomyopathies [C14.280.238]
Chagas Cardiomyopathy [C14.280.238.190]

Below are MeSH descriptors whose meaning is related to "Chagas Cardiomyopathy".

Below are MeSH descriptors whose meaning is more specific than "Chagas Cardiomyopathy".

publications

Timeline | Most Recent

This graph shows the total number of publications written about "Chagas Cardiomyopathy" by people in this website by year, and whether "Chagas Cardiomyopathy" was a major or minor topic of these publications.

Bar chart showing 19 publications over 9 distinct years, with a maximum of 5 publications in 2014

To see the data from this visualization as text, click here.

Year	Major Topic	Minor Topic	Total
2004	0	1	1
2013	0	1	1
2014	4	1	5
2015	2	0	2
2016	0	1	1
2017	2	0	2
2018	1	1	2
2019	2	0	2
2021	3	0	3

Below are the most recent publications written about "Chagas Cardiomyopathy" by people in Profiles.

Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:708325.

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Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. ACS Infect Dis. 2021 06 11; 7(6):1638-1649.

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Rodríguez-Angulo HO, Lamsfus-Calle A, Isoler-Alcaráz J, Galán-Martínez J, Herreros-Cabello A, Callejas-Hernández F, Chorro-de-Villaceballos MA, Maza MC, Santi-Rocca J, Poveda C, Moral-Salmoral JD, Marques J, Mendoza I, Ramírez JD, Guhl F, Carrillo I, Pérez-Tanoira R, Górgolas M, Pérez-Ayala A, Monge-Maillo B, Norman F, Pérez-Molina JA, López-Vélez R, Fresno M, Gironès N. Autoantibodies against the immunodominant sCha epitope discriminate the risk of sudden death in chronic Chagas cardiomyopathy. Ann N Y Acad Sci. 2021 08; 1497(1):27-38.

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Hoffman KA, Reynolds C, Bottazzi ME, Hotez P, Jones K. Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. J Am Heart Assoc. 2019 11 19; 8(22):e013365.

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Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413.

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Jones K, Versteeg L, Damania A, Keegan B, Kendricks A, Pollet J, Cruz-Chan JV, Gusovsky F, Hotez PJ, Bottazzi ME. Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease. Infect Immun. 2018 04; 86(4).

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Koo SJ, Szczesny B, Wan X, Putluri N, Garg NJ. Pentose Phosphate Shunt Modulates Reactive Oxygen Species and Nitric Oxide Production Controlling Trypanosoma cruzi in Macrophages. Front Immunol. 2018; 9:202.

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Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9).

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Garcia MN, Burroughs H, Gorchakov R, Gunter SM, Dumonteil E, Murray KO, Herrera CP. Molecular identification and genotyping of Trypanosoma cruzi DNA in autochthonous Chagas disease patients from Texas, USA. Infect Genet Evol. 2017 04; 49:151-156.

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Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Dumonteil E, Bottazzi ME, Hotez PJ. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87.

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