"Cisplatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An inorganic and water-soluble platinum complex. After undergoing hydrolysis, it reacts with DNA to produce both intra and interstrand crosslinks. These crosslinks appear to impair replication and transcription of DNA. The cytotoxicity of cisplatin correlates with cellular arrest in the G2 phase of the cell cycle.
| Descriptor ID |
D002945
|
| MeSH Number(s) |
D01.210.375 D01.625.125 D01.710.100
|
| Concept/Terms |
Cisplatin- Cisplatin
- cis-Diamminedichloroplatinum(II)
- Platinum Diamminodichloride
- Diamminodichloride, Platinum
- cis-Platinum
- cis Platinum
- Dichlorodiammineplatinum
- cis-Diamminedichloroplatinum
- cis Diamminedichloroplatinum
- cis-Dichlorodiammineplatinum(II)
|
Below are MeSH descriptors whose meaning is more general than "Cisplatin".
Below are MeSH descriptors whose meaning is more specific than "Cisplatin".
This graph shows the total number of publications written about "Cisplatin" by people in this website by year, and whether "Cisplatin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 1 | 0 | 1 |
| 1997 | 1 | 1 | 2 |
| 1998 | 2 | 3 | 5 |
| 1999 | 1 | 1 | 2 |
| 2000 | 0 | 4 | 4 |
| 2001 | 0 | 4 | 4 |
| 2002 | 2 | 2 | 4 |
| 2003 | 4 | 3 | 7 |
| 2004 | 4 | 4 | 8 |
| 2005 | 1 | 3 | 4 |
| 2006 | 1 | 1 | 2 |
| 2007 | 1 | 7 | 8 |
| 2008 | 5 | 6 | 11 |
| 2009 | 0 | 4 | 4 |
| 2010 | 1 | 5 | 6 |
| 2011 | 2 | 6 | 8 |
| 2012 | 1 | 4 | 5 |
| 2013 | 4 | 4 | 8 |
| 2014 | 3 | 6 | 9 |
| 2015 | 5 | 8 | 13 |
| 2016 | 3 | 2 | 5 |
| 2017 | 2 | 2 | 4 |
| 2018 | 5 | 1 | 6 |
| 2019 | 8 | 3 | 11 |
| 2020 | 0 | 6 | 6 |
| 2021 | 1 | 5 | 6 |
| 2022 | 1 | 2 | 3 |
| 2023 | 0 | 9 | 9 |
| 2024 | 4 | 6 | 10 |
| 2025 | 7 | 3 | 10 |
| 2026 | 0 | 1 | 1 |
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Below are the most recent publications written about "Cisplatin" by people in Profiles.
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Prognostic value of visually and computationally assessed tumor-infiltrating lymphocytes in early-stage triple-negative breast cancer (TBCRC-030). J Natl Cancer Inst. 2026 Jan 01; 118(1):141-149.
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Naringenin-functionalized polyester nanoparticles improve oral urolithin A delivery and protect against cisplatin-induced kidney injury via heme oxygenase-1 activation and mitochondrial quality control. J Pharmacol Exp Ther. 2026 Feb; 393(2):103794.
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Bypassing cisplatin resistance in Nrf2 hyperactivated head and neck cancer through effective PI3Kinase targeting. Br J Cancer. 2025 Dec; 133(12):1802-1814.
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Cisplatin-ineligible patients with muscle-invasive bladder cancer demonstrate poor long-term survival following immediate radical cystectomy. BJU Int. 2026 Jan; 137(1):181-188.
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Dual-function polyester nanoparticles for amplified anti-inflammatory effects. Sci Adv. 2025 Aug 08; 11(32):eadw1358.
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Integrated network pharmacology and molecular docking combined with metabolomics to identify the pharmacological mechanisms of Jiedu Huoxue decoction against cisplatin-induced acute kidney injury. J Ethnopharmacol. 2025 Jul 24; 351:120088.
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Understanding Hydronephrosis Occurrence by an Individual-Kidney Level Analysis of all Events Postchemoradiation Therapy for Locally Advanced Cervical Cancer. Int J Radiat Oncol Biol Phys. 2025 Oct 01; 123(2):513-522.
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Development and Validation of a Novel Prediction Model for Hearing Loss From Cisplatin Chemotherapy. J Clin Oncol. 2025 Jul; 43(19):2173-2183.
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Feasibility and Safety of Intratympanic Administration of Sustained-Exposure Dexamethasone Thermosensitive Gel (OTO-104) for Prevention of Cisplatin-Induced Hearing Loss in Children: A Multisite Phase 2 Randomized Clinical Trial. Pediatr Blood Cancer. 2025 Jun; 72(6):e31680.
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Real-World Experience Using Sodium Thiosulfate Pentahydrate Off-Label for Cisplatin Otoprotection in Children, Adolescents, and Young Adults. Pediatr Blood Cancer. 2025 May; 72(5):e31631.