"Nodal Protein" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The founding member of the nodal signaling ligand family of proteins. Nodal protein was originally discovered in the region of the mouse embryo primitive streak referred to as HENSEN'S NODE. It is expressed asymmetrically on the left side in chordates and plays a critical role in the genesis of left-right asymmetry during vertebrate development.
| Descriptor ID |
D055457
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| MeSH Number(s) |
D12.644.276.954.550.650 D12.776.467.942.550.650 D23.529.942.550.650
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Nodal Protein".
Below are MeSH descriptors whose meaning is more specific than "Nodal Protein".
This graph shows the total number of publications written about "Nodal Protein" by people in this website by year, and whether "Nodal Protein" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1996 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2005 | 0 | 1 | 1 |
| 2006 | 0 | 3 | 3 |
| 2008 | 1 | 1 | 2 |
| 2009 | 1 | 0 | 1 |
| 2012 | 1 | 0 | 1 |
| 2020 | 1 | 0 | 1 |
| 2024 | 0 | 1 | 1 |
| 2025 | 1 | 0 | 1 |
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Below are the most recent publications written about "Nodal Protein" by people in Profiles.
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Temporal dynamics of BMP/Nodal ratio drive tissue-specific gastrulation morphogenesis. Development. 2025 05 01; 152(9).
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NODAL variants are associated with a continuum of laterality defects from simple D-transposition of the great arteries to heterotaxy. Genome Med. 2024 04 03; 16(1):53.
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Nodal and planar cell polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. Elife. 2020 04 22; 9.
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NODAL in the uterus is necessary for proper placental development and maintenance of pregnancy. Biol Reprod. 2012 Jun; 86(6):194.
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Back to the embryonic stage: Nodal as a biomarker for breast cancer progression. Breast Cancer Res. 2012 May 21; 14(3):105.
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Cumulative ligand activity of NODAL mutations and modifiers are linked to human heart defects and holoprosencephaly. Mol Genet Metab. 2009 Sep-Oct; 98(1-2):225-34.
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Identification and functional characterization of NODAL rare variants in heterotaxy and isolated cardiovascular malformations. Hum Mol Genet. 2009 Mar 01; 18(5):861-71.
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Reduced NODAL signaling strength via mutation of several pathway members including FOXH1 is linked to human heart defects and holoprosencephaly. Am J Hum Genet. 2008 Jul; 83(1):18-29.
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Sesn1 is a novel gene for left-right asymmetry and mediating nodal signaling. Hum Mol Genet. 2006 Nov 15; 15(22):3369-77.
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Heart defects in X-linked heterotaxy: evidence for a genetic interaction of Zic3 with the nodal signaling pathway. Dev Dyn. 2006 Jun; 235(6):1631-7.