"Physostigmine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cholinesterase inhibitor that is rapidly absorbed through membranes. It can be applied topically to the conjunctiva. It also can cross the blood-brain barrier and is used when central nervous system effects are desired, as in the treatment of severe anticholinergic toxicity.
| Descriptor ID |
D010830
|
| MeSH Number(s) |
D02.241.081.251.583.682 D03.132.436.545 D03.633.100.473.402.545
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Physostigmine".
Below are MeSH descriptors whose meaning is more specific than "Physostigmine".
This graph shows the total number of publications written about "Physostigmine" by people in this website by year, and whether "Physostigmine" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 |
| 2002 | 0 | 1 | 1 |
| 2004 | 0 | 1 | 1 |
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Below are the most recent publications written about "Physostigmine" by people in Profiles.
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Activation of cholinergic receptors blocks non-adrenergic non-cholinergic contractions in the rat urinary bladder. Brain Res Bull. 2008 Dec 16; 77(6):420-6.
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Applications of the P50 evoked response to the evaluation of cognitive impairments after traumatic brain injury. Phys Med Rehabil Clin N Am. 2004 Feb; 15(1):177-203, viii.
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Clinical use of cholinomimetic agents: a review. J Head Trauma Rehabil. 2002 Aug; 17(4):314-21.
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Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Zhongguo Yao Li Xue Bao. 1998 Mar; 19(2):128-32.
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Synthesis and pharmacological investigations of 3-(aminoalkylene)-1-aryl-2-thioxo-4,5-imidazolidinedione and 2,4,5-imidazolidinetrione derivatives. Pol J Pharmacol Pharm. 1990 Jan-Feb; 42(1):49-58.
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Long-term outpatient treatment of senile dementia with oral physostigmine. J Clin Psychiatry. 1988 Oct; 49(10):400-4.
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A pediatric phase I and pharmacokinetic study of spirohydantoin mustard. Cancer Res. 1988 Apr 15; 48(8):2292-5.
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Local synaptic interactions in the rat striatum in vitro: a quantitative analysis based on unit discharges. Exp Neurol. 1986 Dec; 94(3):489-96.
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Effects of oral physostigmine and lecithin on memory and attention in closed head-injured patients. Cent Nerv Syst Trauma. 1986; 3(4):333-42.
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Noradrenergic and cholinergic agents in Korsakoff's syndrome. Clin Neuropharmacol. 1986; 9(1):65-70.