Poly(ADP-ribose) Polymerases
"Poly(ADP-ribose) Polymerases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Enzymes that catalyze the transfer of multiple ADP-RIBOSE groups from nicotinamide-adenine dinucleotide (NAD) onto protein targets, thus building up a linear or branched homopolymer of repeating ADP-ribose units i.e., POLY ADENOSINE DIPHOSPHATE RIBOSE.
| Descriptor ID |
D011065
|
| MeSH Number(s) |
D08.811.913.400.725.115.690
|
| Concept/Terms |
Poly(ADP-ribose) Polymerases- Poly(ADP-ribose) Polymerases
- ADP-Ribosyltransferase (Polymerizing)
- Poly(ADP-ribose) Polymerase
- Poly ADP Ribose Polymerase
- Poly ADP Ribose Transferase
- Poly(ADP-Ribose) Transferase
- PARP Polymerase
- Polymerase, PARP
- Poly(ADPribose) Polymerase
- Poly ADP-Ribose Synthase
- Poly ADP Ribose Synthase
- Synthase, Poly ADP-Ribose
- Poly(ADPR) Polymerase
- Poly(ADP-Ribose) Synthase
|
Below are MeSH descriptors whose meaning is more general than "Poly(ADP-ribose) Polymerases".
Below are MeSH descriptors whose meaning is more specific than "Poly(ADP-ribose) Polymerases".
This graph shows the total number of publications written about "Poly(ADP-ribose) Polymerases" by people in this website by year, and whether "Poly(ADP-ribose) Polymerases" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1994 | 0 | 1 | 1 |
| 1996 | 2 | 2 | 4 |
| 1997 | 0 | 1 | 1 |
| 1998 | 2 | 3 | 5 |
| 1999 | 3 | 2 | 5 |
| 2000 | 0 | 2 | 2 |
| 2001 | 0 | 4 | 4 |
| 2002 | 1 | 5 | 6 |
| 2003 | 2 | 9 | 11 |
| 2004 | 0 | 2 | 2 |
| 2005 | 0 | 6 | 6 |
| 2006 | 1 | 2 | 3 |
| 2007 | 2 | 6 | 8 |
| 2008 | 2 | 1 | 3 |
| 2009 | 1 | 7 | 8 |
| 2010 | 2 | 8 | 10 |
| 2011 | 4 | 6 | 10 |
| 2012 | 1 | 9 | 10 |
| 2013 | 1 | 2 | 3 |
| 2014 | 3 | 8 | 11 |
| 2015 | 2 | 4 | 6 |
| 2016 | 3 | 1 | 4 |
| 2017 | 4 | 4 | 8 |
| 2018 | 1 | 1 | 2 |
| 2019 | 2 | 1 | 3 |
| 2020 | 4 | 2 | 6 |
| 2021 | 3 | 1 | 4 |
| 2022 | 0 | 2 | 2 |
| 2023 | 1 | 3 | 4 |
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Below are the most recent publications written about "Poly(ADP-ribose) Polymerases" by people in Profiles.
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Poly (ADP-ribose) Polymerase Inhibition in Advanced Urothelial Carcinoma. JCO Precis Oncol. 2023 08; 7:e2300293.
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The biology behind combining poly [ADP ribose] polymerase and androgen receptor inhibition for metastatic castration-resistant prostate cancer. Eur J Cancer. 2023 10; 192:113249.
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Outcomes of patients with therapy-related myeloid neoplasms after treatment with poly(ADP-ribose) polymerase proteins inhibitors for solid tumours. Br J Haematol. 2023 05; 201(3):e25-e29.
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Clinical Application of Poly(ADP-Ribose) Polymerase (PARP) Inhibitors in Ovarian Cancer. Cancer Treat Res. 2023; 186:71-89.
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Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227.
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The growing role of rucaparib in contemporary treatment of metastatic prostate cancer: a review of efficacy and guidance for side effect management. Expert Rev Anticancer Ther. 2022 07; 22(7):671-679.
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The lactate-NAD+ axis activates cancer-associated fibroblasts by downregulating p62. Cell Rep. 2022 05 10; 39(6):110792.
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Deficiency of PARP-1 and PARP-2 in the mouse uterus results in decidualization failure and pregnancy loss. Proc Natl Acad Sci U S A. 2021 10 05; 118(40).
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Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biol. 2021 11; 47:102132.
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miR-149-PARP-2 Signaling Regulates E-cadherin and N-cadherin Expression in the Murine Model of Endometrium Receptivity. Reprod Sci. 2022 03; 29(3):975-992.