"Thrombomodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
| Descriptor ID |
D018180
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| MeSH Number(s) |
D12.776.395.550.625.800.800 D12.776.543.550.625.800.800 D12.776.543.750.705.675.892.800 D12.776.543.750.750.850.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombomodulin".
Below are MeSH descriptors whose meaning is more specific than "Thrombomodulin".
This graph shows the total number of publications written about "Thrombomodulin" by people in this website by year, and whether "Thrombomodulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1999 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2020 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
| 2025 | 0 | 1 | 1 |
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Below are the most recent publications written about "Thrombomodulin" by people in Profiles.
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Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation. Sci Rep. 2021 11 08; 11(1):21852.
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Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells. PLoS One. 2014; 9(6):e99227.
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Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection. Respir Res. 2013 Jul 05; 14:71.
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JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter. FEBS Lett. 2010 Mar 05; 584(5):852-8.
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C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005 Aug; 138(2):212-22.
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Recombinant human factor VIIa-induced alterations in tissue factor and thrombomodulin in patients with advanced liver cirrhosis. J Gastroenterol Hepatol. 2005 Jun; 20(6):882-9.
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Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res. 2005; 115(5):417-26.
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Tamoxifen-induced tissue factor pathway inhibitor reduction: a clue for an acquired thrombophilic state? Ann Oncol. 2004 Nov; 15(11):1622-6.
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Statins increase thrombomodulin expression and function in human endothelial cells by a nitric oxide-dependent mechanism and counteract tumor necrosis factor alpha-induced thrombomodulin downregulation. Blood Coagul Fibrinolysis. 2003 Sep; 14(6):575-85.
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Modulation of endothelial cell inflammatory integrins and stress markers with rh-factor VIIa in patients with advanced chronic hepatitis C. J Viral Hepat. 2003 Jul; 10(4):310-7.