"Thrombomodulin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface glycoprotein of endothelial cells that binds thrombin and serves as a cofactor in the activation of protein C and its regulation of blood coagulation.
| Descriptor ID |
D018180
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| MeSH Number(s) |
D12.776.395.550.625.800.800 D12.776.543.550.625.800.800 D12.776.543.750.705.675.892.800 D12.776.543.750.750.850.800
|
| Concept/Terms |
|
Below are MeSH descriptors whose meaning is more general than "Thrombomodulin".
Below are MeSH descriptors whose meaning is more specific than "Thrombomodulin".
This graph shows the total number of publications written about "Thrombomodulin" by people in this website by year, and whether "Thrombomodulin" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 1998 | 1 | 1 | 2 |
| 1999 | 0 | 1 | 1 |
| 2000 | 0 | 1 | 1 |
| 2001 | 1 | 0 | 1 |
| 2003 | 1 | 1 | 2 |
| 2004 | 1 | 0 | 1 |
| 2005 | 2 | 0 | 2 |
| 2006 | 0 | 1 | 1 |
| 2010 | 1 | 0 | 1 |
| 2013 | 0 | 1 | 1 |
| 2014 | 0 | 1 | 1 |
| 2015 | 0 | 1 | 1 |
| 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Thrombomodulin" by people in Profiles.
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Recombinant Thrombomodulin Has Anti-tumor Effects and Enhances the Effects of Gemcitabine for Pancreatic Cancer Through G-protein Coupled Receptor 15. Anticancer Res. 2022 Oct; 42(10):4679-4687.
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Integrated PERSEVERE and endothelial biomarker risk model predicts death and persistent MODS in pediatric septic shock: a secondary analysis of a prospective?observational?study. Crit Care. 2022 07 11; 26(1):210.
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Human endothelial cells and fibroblasts express and produce the coagulation proteins necessary for thrombin generation. Sci Rep. 2021 11 08; 11(1):21852.
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STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16+ Monocytes and CD141+ Dendritic Cells. J Immunol. 2021 11 15; 207(10):2423-2432.
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Expression of a Synthetic Gene of CTDM by Transgenic Animals. Transplant Proc. 2016 May; 48(4):1279-81.
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Protein C Thr315Ala variant results in gain of function but manifests as type II deficiency in diagnostic assays. Blood. 2015 Apr 09; 125(15):2428-34.
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Paramyxovirus infection regulates T cell responses by BDCA-1+ and BDCA-3+ myeloid dendritic cells. PLoS One. 2014; 9(6):e99227.
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Differential response of BDCA-1+ and BDCA-3+ myeloid dendritic cells to respiratory syncytial virus infection. Respir Res. 2013 Jul 05; 14:71.
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The interplay between hemostasis and malignancy: the oral cancer paradigm. Anticancer Res. 2012 May; 32(5):1791-800.
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JNK-ATF-2 inhibits thrombomodulin (TM) expression by recruiting histone deacetylase4 (HDAC4) and forming a transcriptional repression complex in the TM promoter. FEBS Lett. 2010 Mar 05; 584(5):852-8.