"Metribolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
| Descriptor ID |
D015741
|
| MeSH Number(s) |
D04.210.500.365.415.550
|
| Concept/Terms |
Metribolone- Metribolone
- 17 beta-Hydroxy-17 alpha-methylestra-4,9,11-trien-3-one
- Methyltrienolone
R-1881- R-1881
- R 1881
- R1881
- Ru-1881
- Ru 1881
- Ru1881
|
Below are MeSH descriptors whose meaning is more general than "Metribolone".
Below are MeSH descriptors whose meaning is more specific than "Metribolone".
This graph shows the total number of publications written about "Metribolone" by people in this website by year, and whether "Metribolone" was a major or minor topic of these publications.
To see the data from this visualization as text,
click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2002 | 0 | 1 | 1 |
| 2003 | 0 | 1 | 1 |
| 2006 | 1 | 1 | 2 |
| 2011 | 0 | 2 | 2 |
| 2013 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metribolone" by people in Profiles.
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GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer. 2018 04; 25(4):453-469.
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Androgens regulate prostate cancer cell growth via an AMPK-PGC-1a-mediated metabolic switch. Oncogene. 2014 Nov 06; 33(45):5251-61.
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Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62.
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Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer. 2013 Feb 14; 12:13.
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Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One. 2011; 6(9):e25187.
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Novel role of androgens in mitochondrial fission and apoptosis. Mol Cancer Res. 2011 Aug; 9(8):1067-77.
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Role of TMPRSS2-ERG gene fusion in negative regulation of PSMA expression. PLoS One. 2011; 6(6):e21319.
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Androgens modulate expression of transcription intermediary factor 2, an androgen receptor coactivator whose expression level correlates with early biochemical recurrence in prostate cancer. Cancer Res. 2006 Nov 01; 66(21):10594-602.
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Quantifying effects of ligands on androgen receptor nuclear translocation, intranuclear dynamics, and solubility. J Cell Biochem. 2006 Jul 01; 98(4):770-88.
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Repressors of androgen and progesterone receptor action. J Biol Chem. 2003 Aug 15; 278(33):31136-48.