"Metribolone" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A synthetic non-aromatizable androgen and anabolic steroid. It binds strongly to the androgen receptor and has therefore also been used as an affinity label for this receptor in the prostate and in prostatic tumors.
| Descriptor ID |
D015741
|
| MeSH Number(s) |
D04.210.500.365.415.550
|
| Concept/Terms |
Metribolone- Metribolone
- 17 beta-Hydroxy-17 alpha-methylestra-4,9,11-trien-3-one
- Methyltrienolone
R-1881- R-1881
- R 1881
- R1881
- Ru-1881
- Ru 1881
- Ru1881
|
Below are MeSH descriptors whose meaning is more general than "Metribolone".
Below are MeSH descriptors whose meaning is more specific than "Metribolone".
This graph shows the total number of publications written about "Metribolone" by people in this website by year, and whether "Metribolone" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 1997 | 1 | 0 | 1 |
| 2011 | 0 | 1 | 1 |
| 2013 | 0 | 2 | 2 |
| 2018 | 0 | 1 | 1 |
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Below are the most recent publications written about "Metribolone" by people in Profiles.
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GLUT12 promotes prostate cancer cell growth and is regulated by androgens and CaMKK2 signaling. Endocr Relat Cancer. 2018 04; 25(4):453-469.
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Androgens regulate prostate cancer cell growth via an AMPK-PGC-1a-mediated metabolic switch. Oncogene. 2014 Nov 06; 33(45):5251-61.
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Androgen receptor agonism promotes an osteogenic gene program in preadipocytes. Biochem Biophys Res Commun. 2013 May 03; 434(2):357-62.
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Transcription signatures encoded by ultraconserved genomic regions in human prostate cancer. Mol Cancer. 2013 Feb 14; 12:13.
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Repression of androgen receptor transcription through the E2F1/DNMT1 axis. PLoS One. 2011; 6(9):e25187.
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Novel role of androgens in mitochondrial fission and apoptosis. Mol Cancer Res. 2011 Aug; 9(8):1067-77.
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Androgen and epidermal growth factor down-regulate cyclin-dependent kinase inhibitor p27Kip1 and costimulate proliferation of MDA PCa 2a and MDA PCa 2b prostate cancer cells. Clin Cancer Res. 1999 Aug; 5(8):2171-7.
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Mechanistic studies of the effects of the retinoid N-(4-hydroxyphenyl)retinamide on prostate cancer cell growth and apoptosis. Mol Carcinog. 1999 Mar; 24(3):160-8.
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Regulation of androgen-dependent prostatic cancer cell growth: androgen regulation of CDK2, CDK4, and CKI p16 genes. Cancer Res. 1997 Oct 15; 57(20):4511-6.
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The human prostatic carcinoma cell line LNCaP expresses biologically active, specific receptors for 1 alpha,25-dihydroxyvitamin D3. Cancer Res. 1992 Feb 01; 52(3):515-20.