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YUNPING LEI

TitleAssistant Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
Address6501 Fannin St
Houston, TX 77030
ORCID ORCID Icon0000-0003-1504-0884 Additional info
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    Other Positions
    TitleAssistant Professor
    InstitutionBaylor College of Medicine
    DepartmentCenter for Precision Environmental Health
    DivisionCenter for Precision Env Health


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    R01HD100535     (FINNELL, RICHARD H.;LEI, YUNPING)Mar 10, 2020 - Feb 28, 2025
    NIH
    Role of Slc25a32 and Its Interaction with Lrp6 in the Etiology of Neural Tube Defects
    Role: Principal Investigator
    R01HD081216     (FINNELL, RICHARD H.)Aug 10, 2015 - Jun 30, 2021
    NIH
    Folic Acid, Parental Mutation Rates and the Risk for Neural Tube Defects
    Role: Co-Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yang L, Chen X, Lee C, Shi J, Lawrence EB, Zhang L, Li Y, Gao N, Jung SY, Creighton CJ, Li JJ, Cui Y, Arimura S, Lei Y, Li W, Shen L. Functional characterization of age-dependent p16 epimutation reveals biological drivers and therapeutic targets for colorectal cancer. J Exp Clin Cancer Res. 2023 May 04; 42(1):113. PMID: 37143122; PMCID: PMC10157929.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Sok P, Sabo A, Almli LM, Jenkins MM, Nembhard WN, Agopian AJ, Bamshad MJ, Blue EE, Brody LC, Brown AL, Browne ML, Canfield MA, Carmichael SL, Chong JX, Dugan-Perez S, Feldkamp ML, Finnell RH, Gibbs RA, Kay DM, Lei Y, Meng Q, Moore CA, Mullikin JC, Muzny D, Olshan AF, Pangilinan F, Reefhuis J, Romitti PA, Schraw JM, Shaw GM, Werler MM, Harpavat S, Lupo PJ, University of Washington Center for Mendelian Genomics, NISC Comparative Sequencing Program, the Nat. Exome-wide assessment of isolated biliary atresia: A report from the National Birth Defects Prevention Study using child-parent trios and a case-control design to identify novel rare variants. Am J Med Genet A. 2023 06; 191(6):1546-1556. PMID: 36942736; PMCID: PMC10947986.
      Citations:    Fields:    Translation:Humans
    3. Cao X, Xu J, Lin YL, Cabrera RM, Chen Q, Zhang C, Steele JW, Han X, Gross SS, Wlodarczyk BJ, Lupski JR, Li W, Wang H, Finnell RH, Lei Y. Excess folic acid intake increases DNA de novo point mutations. Cell Discov. 2023 Feb 28; 9(1):22. PMID: 36849450; PMCID: PMC9970956.
      Citations: 4     
    4. Han X, Cao X, Cabrera RM, Pimienta Ramirez PA, Zhang C, Ramaekers VT, Finnell RH, Lei Y. KDM6B Variants May Contribute to the Pathophysiology of Human Cerebral Folate Deficiency. Biology (Basel). 2022 Dec 31; 12(1). PMID: 36671766; PMCID: PMC9855468.
      Citations: 3     
    5. Caiaffa CD, Fonteles CSR, Yunping L, Finnell RH. Gene-environment interactions underlying the etiology of neural tube defects. Curr Top Dev Biol. 2023; 152:193-220. PMID: 36707212.
      Citations:    Fields:    Translation:Humans
    6. Han X, Cao X, Aguiar-Pulido V, Yang W, Karki M, Ramirez PAP, Cabrera RM, Lin YL, Wlodarczyk BJ, Shaw GM, Ross ME, Zhang C, Finnell RH, Lei Y. CIC missense variants contribute to susceptibility for spina bifida. Hum Mutat. 2022 12; 43(12):2021-2032. PMID: 36054333; PMCID: PMC9772115.
      Citations:    
    7. Aguiar-Pulido V, Wolujewicz P, Martinez-Fundichely A, Elhaik E, Thareja G, Abdel Aleem A, Chalhoub N, Cuykendall T, Al-Zamer J, Lei Y, El-Bashir H, Musser JM, Al-Kaabi A, Shaw GM, Khurana E, Suhre K, Mason CE, Elemento O, Finnell RH, Ross ME. Systems biology analysis of human genomes points to key pathways conferring spina bifida risk. Proc Natl Acad Sci U S A. 2021 12 21; 118(51). PMID: 34916285; PMCID: PMC8713748.
      Citations: 1     Fields:    Translation:Humans
    8. Abdel Fattah AR, Daza B, Rustandi G, Gorissen B, Poovathingal S, Davie K, Barrasa-Fano J, Cao X, Rosenzweig DH, Lei Y, Finnell R, Verfaillie C, Sampaolesi M, Dedecker P, Van Oosterwyck H, Aerts S, Ranga A, Berrocal-Rubio M?, C?ndor M. Actuation enhances patterning in human neural tube organoids. Nat Commun. 2021 05 27; 12(1):3192. PMID: 34045434; PMCID: PMC8159931.
      Citations: 5     Fields:    Translation:HumansCells
    9. Finnell RH, Caiaffa CD, Kim SE, Lei Y, Steele J, Cao X, Tukeman G, Lin YL, Cabrera RM, Wlodarczyk BJ. Gene Environment Interactions in the Etiology of Neural Tube Defects. Front Genet. 2021; 12:659612. PMID: 34040637; PMCID: PMC8143787.
      Citations: 5     
    10. Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2021 Apr; 31(4):488. PMID: 33564133; PMCID: PMC8115563.
      Citations:    Fields:    
    11. Tian T, Cao X, Chen Y, Jin L, Li Z, Han X, Lin Y, Wlodarczyk BJ, Finnell RH, Yuan Z, Wang L, Ren A, Lei Y. Somatic and de novo Germline Variants of MEDs in Human Neural Tube Defects. Front Cell Dev Biol. 2021; 9:641831. PMID: 33748132; PMCID: PMC7969791.
      Citations: 5     
    12. Lei Y, Ludorf KL, Yu X, Benjamin RH, Gu X, Lin Y, Finnell RH, Mitchell LE, Musfee FI, Malik S, Canfield MA, Morrison AC, Hobbs CA, Van Zutphen AR, Fisher S, Agopian AJ. Maternal Hypertension-Related Genotypes and Congenital Heart Defects. Am J Hypertens. 2021 02 18; 34(1):82-91. PMID: 32710738; PMCID: PMC7891240.
      Citations:    Fields:    Translation:Humans
    13. Tian T, Lai X, Xiang K, Han X, Yin S, Cabrera RM, Steele JW, Lei Y, Cao X, Finnell RH, Wang L, Ren A. Hypermethylation of PI3K-AKT signalling pathway genes is associated with human neural tube defects. Epigenetics. 2022 Jan-Feb; 17(2):133-146. PMID: 33491544; PMCID: PMC8865305.
      Citations:    Fields:    Translation:HumansCells
    14. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. Correction to: Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2021 Jan 27; 14(1):29. PMID: 33504353; PMCID: PMC7841986.
      Citations:    Fields:    
    15. Tian T, Cao X, Kim SE, Lin YL, Steele JW, Cabrera RM, Karki M, Yang W, Marini NJ, Hoffman EN, Han X, Hu C, Wang L, Wlodarczyk BJ, Shaw GM, Ren A, Finnell RH, Lei Y. FKBP8 variants are risk factors for spina bifida. Hum Mol Genet. 2020 11 04; 29(18):3132-3144. PMID: 32969478; PMCID: PMC7645715.
      Citations: 3     Fields:    Translation:HumansAnimals
    16. Cao X, Kim SE, Cabrera RM, Wlodarczyk BJ, Zhu H, Parker M, Lin Y, Steele JW, Han X, Finnell RH, Lei Y, Wolf A, Ramaekers VT, Steinfeld R. CIC de novo loss of function variants contribute to cerebral folate deficiency by downregulating FOLR1 expression. J Med Genet. 2021 07; 58(7):484-494. PMID: 32820034; PMCID: PMC7895856.
      Citations: 3     Fields:    Translation:HumansCells
    17. Taiwo TE, Cao X, Cabrera RM, Lei Y, Finnell RH. Approaches to studying the genomic architecture of complex birth defects. Prenat Diagn. 2020 08; 40(9):1047-1055. PMID: 32468575; PMCID: PMC8117178.
      Citations: 2     Fields:    Translation:HumansAnimals
    18. Liu L, Liu W, Shi Y, Li L, Gao Y, Lei Y, Finnell R, Zhang T, Zhang F, Jin L, Li H, Tao W, Wang H. DVL mutations identified from human neural tube defects and Dandy-Walker malformation obstruct the Wnt signaling pathway. J Genet Genomics. 2020 06 20; 47(6):301-310. PMID: 32900645.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Tian T, Lei Y, Chen Y, Guo Y, Jin L, Finnell RH, Wang L, Ren A. Rare copy number variations of planar cell polarity genes are associated with human neural tube defects. Neurogenetics. 2020 07; 21(3):217-225. PMID: 32388773.
      Citations: 2     Fields:    Translation:Humans
    20. Tian T, Lei Y, Chen Y, Karki M, Jin L, Finnell RH, Wang L, Ren A. Somatic mutations in planar cell polarity genes in neural tissue from human fetuses with neural tube defects. Hum Genet. 2020 Oct; 139(10):1299-1314. PMID: 32356230; PMCID: PMC7487040.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    21. Lei Y, Finnell RH. New myotonic dystrophy type 1 mouse model. Cell Res. 2020 02; 30(2):99-100. PMID: 31953529; PMCID: PMC7015057.
      Citations: 1     Fields:    Translation:Animals
    22. Cao X, Tian T, Steele JW, Cabrera RM, Aguiar-Pulido V, Wadhwa S, Bhavani N, Bi P, Gargurevich NH, Hoffman EN, Cai CQ, Marini NJ, Yang W, Shaw GM, Ross ME, Finnell RH, Lei Y. Loss of RAD9B impairs early neural development and contributes to the risk for human spina bifida. Hum Mutat. 2020 04; 41(4):786-799. PMID: 31898828; PMCID: PMC7185173.
      Citations: 8     Fields:    Translation:HumansCells
    23. Chen Z, Lin X, Lei Y, Chen H, Finnell RH, Wang Y, Xu J, Lu D, Xie H, Chen F. Genome-wide association study in Chinese cohort identifies one novel hypospadias risk associated locus at 12q13.13. BMC Med Genomics. 2019 12 19; 12(1):196. PMID: 31856834; PMCID: PMC6923877.
      Citations: 2     Fields:    Translation:Humans
    24. Wang L, Ren A, Tian T, Li N, Cao X, Zhang P, Jin L, Li Z, Shen Y, Zhang B, Finnell RH, Lei Y. Whole-Exome Sequencing Identifies Damaging de novo Variants in Anencephalic Cases. Front Neurosci. 2019; 13:1285. PMID: 31849593; PMCID: PMC6896715.
      Citations: 5     
    25. Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. Author Correction: Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2019 Sep; 29(9):776. PMID: 31346254; PMCID: PMC6796949.
      Citations: 1     Fields:    
    26. Kousa YA, Zhu H, Fakhouri WD, Lei Y, Kinoshita A, Roushangar RR, Patel NK, Agopian AJ, Yang W, Leslie EJ, Busch TD, Mansour TA, Li X, Smith AL, Li EB, Sharma DB, Williams TJ, Chai Y, Amendt BA, Liao EC, Mitchell LE, Bassuk AG, Gregory S, Ashley-Koch A, Shaw GM, Finnell RH, Schutte BC. The TFAP2A-IRF6-GRHL3 genetic pathway is conserved in neurulation. Hum Mol Genet. 2019 05 15; 28(10):1726-1737. PMID: 30689861; PMCID: PMC6494790.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    27. Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw GM, Agopian AJ, National Birth Defects Prevention Study. Maternal genetic markers for risk of celiac disease and their potential association with neural tube defects in offspring. Mol Genet Genomic Med. 2019 06; 7(6):e688. PMID: 30968606; PMCID: PMC6565562.
      Citations: 1     Fields:    Translation:Humans
    28. Hoang TT, Lei Y, Mitchell LE, Sharma SV, Swartz MD, Waller DK, Finnell RH, Benjamin RH, Browne ML, Canfield MA, Lupo PJ, McKenzie P, Shaw G, Agopian AJ, National Birth Defects Prevention Study. Maternal Lactase Polymorphism (rs4988235) Is Associated with Neural Tube Defects in Offspring in the National Birth Defects Prevention Study. J Nutr. 2019 02 01; 149(2):295-303. PMID: 30689919.
      Citations: 2     Fields:    Translation:Humans
    29. Lei Y, Kim SE, Chen Z, Cao X, Zhu H, Yang W, Shaw GM, Zheng Y, Zhang T, Wang HY, Finnell RH. Variants identified in PTK7 associated with neural tube defects. Mol Genet Genomic Med. 2019 04; 7(4):e00584. PMID: 30689296; PMCID: PMC6465732.
      Citations: 16     Fields:    Translation:HumansCells
    30. Kim SE, Lei Y, Hwang SH, Wlodarczyk BJ, Mukhopadhyay S, Shaw GM, Ross ME, Finnell RH. Dominant negative GPR161 rare variants are risk factors of human spina bifida. Hum Mol Genet. 2019 01 15; 28(2):200-208. PMID: 30256984; PMCID: PMC6321953.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    31. Chen Z, Lei Y, Zheng Y, Aguiar-Pulido V, Ross ME, Peng R, Jin L, Zhang T, Finnell RH, Wang H. Threshold for neural tube defect risk by accumulated singleton loss-of-function variants. Cell Res. 2018 10; 28(10):1039-1041. PMID: 29976953; PMCID: PMC6170406.
      Citations: 26     Fields:    Translation:Humans
    32. Dong Y, Wang L, Lei Y, Yang N, Cabrera RM, Finnell RH, Ren A. Gene variants in the folate pathway are associated with increased levels of folate receptor autoantibodies. Birth Defects Res. 2018 07 17; 110(12):973-981. PMID: 29732742; PMCID: PMC6276117.
      Citations: 4     Fields:    Translation:Humans
    33. Kim J, Lei Y, Guo J, Kim SE, Wlodarczyk BJ, Cabrera RM, Lin YL, Nilsson TK, Zhang T, Ren A, Wang L, Yuan Z, Zheng YF, Wang HY, Finnell RH. Formate rescues neural tube defects caused by mutations in Slc25a32. Proc Natl Acad Sci U S A. 2018 05 01; 115(18):4690-4695. PMID: 29666258; PMCID: PMC5939102.
      Citations: 17     Fields:    Translation:HumansAnimals
    34. Chen Z, Lei Y, Cao X, Zheng Y, Wang F, Bao Y, Peng R, Finnell RH, Zhang T, Wang H. Genetic analysis of Wnt/PCP genes in neural tube defects. BMC Med Genomics. 2018 04 04; 11(1):38. PMID: 29618362; PMCID: PMC5885375.
      Citations: 20     Fields:    Translation:HumansCells
    35. Wang L, Xiao Y, Tian T, Jin L, Lei Y, Finnell RH, Ren A. Digenic variants of planar cell polarity genes in human neural tube defect patients. Mol Genet Metab. 2018 05; 124(1):94-100. PMID: 29573971; PMCID: PMC5966321.
      Citations: 17     Fields:    Translation:Humans
    36. Lu HC, Tan Q, Rousseaux MW, Wang W, Kim JY, Richman R, Wan YW, Yeh SY, Patel JM, Liu X, Lin T, Lee Y, Fryer JD, Han J, Chahrour M, Finnell RH, Lei Y, Zurita-Jimenez ME, Ahimaz P, Anyane-Yeboa K, Lehalle D, Jean-Marcais N, Mosca-Boidron AL, Thevenon J, Cousin MA, Bro DE, Lanpher BC, Klee EW, Alexander N, Bainbridge MN, Orr HT, Sillitoe RV, Ljungberg MC, Liu Z, Schaaf CP, Zoghbi HY, Van Maldergem L. Disruption of the ATXN1-CIC complex causes a spectrum of neurobehavioral phenotypes in mice and humans. Nat Genet. 2017 Apr; 49(4):527-536. PMID: 28288114; PMCID: PMC5374026.
      Citations: 49     Fields:    Translation:HumansAnimals
    37. d'Esposito AM, Kolatsi-Joannou M, Patel V, Igarashi P, Lei Y, Finnell RH, Lythgoe MF, Woolf AS, Papakrivopoulou E, Long DA, Brz?ska HL. Planar cell polarity genes Celsr1 and Vangl2 are necessary for kidney growth, differentiation, and rostrocaudal patterning. Kidney Int. 2016 12; 90(6):1274-1284. PMID: 27597235; PMCID: PMC5126096.
      Citations: 17     Fields:    Translation:HumansAnimals
    38. Lei Y, Finnell RH. New Techniques for the Study of Neural Tube Defects. Adv Tech Biol Med. 2016 Feb; 4(1). PMID: 27066597; PMCID: PMC4826067.
      Citations: 4     
    39. Cantarel BL, Lei Y, Weaver D, Zhu H, Farrell A, Benstead-Hume G, Reese J, Finnell RH. Analysis of archived residual newborn screening blood spots after whole genome amplification. BMC Genomics. 2015 Aug 13; 16:602. PMID: 26268606; PMCID: PMC4535253.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    40. Lei Y, Fathe K, McCartney D, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Rare LRP6 variants identified in spina bifida patients. Hum Mutat. 2015 Mar; 36(3):342-9. PMID: 25546815; PMCID: PMC4361299.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    41. Lei Y, Zhu H, Yang W, Ross ME, Shaw GM, Finnell RH. Identification of novel CELSR1 mutations in spina bifida. PLoS One. 2014; 9(3):e92207. PMID: 24632739; PMCID: PMC3954890.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    42. Lei Y, Zhu H, Duhon C, Yang W, Ross ME, Shaw GM, Finnell RH. Mutations in planar cell polarity gene SCRIB are associated with spina bifida. PLoS One. 2013; 8(7):e69262. PMID: 23922697; PMCID: PMC3724847.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    43. Yang XY, Zhou XY, Wang QQ, Li H, Chen Y, Lei YP, Ma XH, Kong P, Shi Y, Jin L, Zhang T, Wang HY. Mutations in the COPII vesicle component gene SEC24B are associated with human neural tube defects. Hum Mutat. 2013 Aug; 34(8):1094-101. PMID: 23592378.
      Citations:    
    44. Lin R, Lei Y, Yuan Z, Ju H, Li D. Angiotensinogen gene M235T and T174M polymorphisms and susceptibility of pre-eclampsia: a meta-analysis. Ann Hum Genet. 2012 Sep; 76(5):377-86. PMID: 22881375.
      Citations:    
    45. Shi Y, Ding Y, Lei YP, Yang XY, Xie GM, Wen J, Cai CQ, Li H, Chen Y, Zhang T, Wu BL, Jin L, Chen YG, Wang HY. Identification of novel rare mutations of DACT1 in human neural tube defects. Hum Mutat. 2012 Oct; 33(10):1450-5. PMID: 22610794.
      Citations:    
    46. Li H, Choy KW, Lei YP, Wang W, Wang HY, Chen Y. A novel 15bp micro-duplication in SF-1 gene showing diverse phenotypic spectrum in a Chinese family. J Matern Fetal Neonatal Med. 2011 Jan; 24(1):132-6. PMID: 20350242.
      Citations:    
    47. Chen X, Guo J, Lei Y, Zou J, Lu X, Bao Y, Wu L, Wu J, Zheng X, Shen Y, Wu BL, Zhang T. Global DNA hypomethylation is associated with NTD-affected pregnancy: A case-control study. Birth Defects Res A Clin Mol Teratol. 2010 Jul; 88(7):575-81. PMID: 20641100.
      Citations:    
    48. Lei YP, Zhang T, Li H, Wu BL, Jin L, Wang HY. VANGL2 mutations in human cranial neural-tube defects. N Engl J Med. 2010 Jun 10; 362(23):2232-5. PMID: 20558380.
      Citations:    
    49. Lu J, Zhang S, Chen D, Wang H, Wu W, Wang X, Lei Y, Wang J, Qian J, Fan W, Hu Z, Jin L, Shen H, Huang W, Wei Q, Lu D. Functional characterization of a promoter polymorphism in APE1/Ref-1 that contributes to reduced lung cancer susceptibility. FASEB J. 2009 Oct; 23(10):3459-69. PMID: 19541747.
      Citations:    
    50. Chen Y, Lei YP, Zheng HX, Wang W, Cheng HB, Zhang J, Wang HY, Jin L, Li H. A novel mutation (C1425Y) in the FBN2 gene in a father and son with congenital contractural arachnodactyly. Genet Test Mol Biomarkers. 2009 Jun; 13(3):295-300. PMID: 19473076.
      Citations:    
    51. Cheng B, Tang W, He L, Dong Y, Lu J, Lei Y, Yu H, Zhang J, Xiao C. Genetic imprint of the Mongol: signal from phylogeographic analysis of mitochondrial DNA. J Hum Genet. 2008; 53(10):905-913. PMID: 18769869.
      Citations:    
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