InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yu D, Kaur G, Blumenthal RM, Zhang X, Cheng X. Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. J Biol Chem. 2021 Jan 08; 100270. PMID: 33428944.
      Citations:    Fields:    
    2. Zhang X, Blumenthal RM, Cheng X. A Role for N6-Methyladenine in DNA Damage Repair. Trends Biochem Sci. 2021 Mar; 46(3):175-183. PMID: 33077363.
      Citations:    Fields:    
    3. Woodcock CB, Horton JR, Zhang X, Blumenthal RM, Cheng X. Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences. Nucleic Acids Res. 2020 10 09; 48(18):10034-10044. PMID: 32453412.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Woodcock CB, Horton JR, Zhou J, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res. 2020 10 09; 48(18):10329-10341. PMID: 32663306.
      Citations: 2     Fields:    Translation:HumansCells
    5. Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes Dev. 2020 Oct 01. PMID: 33004415.
      Citations: 3     Fields:    
    6. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer. 2020 Jun; 2(2):zcaa007. PMID: 32743551.
      Citations: 1     
    7. Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell. 2020 03; 11(3):214-218. PMID: 31970665.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Horton JR, Yang J, Zhang X, Petronzio T, Fomenkov A, Wilson GG, Roberts RJ, Cheng X. Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 Å. Nucleic Acids Res. 2020 02 20; 48(3):1466-1478. PMID: 31879785.
      Citations:    Fields:    Translation:Cells
    9. Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Corrêa IR, Wu T, Vedadi M, Zhang X, Cheng X. Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro. Cell Discov. 2019; 5:63. PMID: 31885874.
      Citations: 6     
    10. Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev. 2019 12 01; 33(23-24):1702-1717. PMID: 31699778.
      Citations: 4     Fields:    Translation:HumansCells
    11. Yang J, Zhang X, Blumenthal RM, Cheng X. Detection of DNA Modifications by Sequence-Specific Transcription Factors. J Mol Biol. 2019 Oct 15. PMID: 31626807.
      Citations: 1     Fields:    
    12. Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site. Nat Commun. 2019 10 10; 10(1):4600. PMID: 31601797.
      Citations: 4     Fields:    Translation:Cells
    13. Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res. 2019 09 19; 47(16):8375-8387. PMID: 31081034.
      Citations: 4     Fields:    Translation:HumansCells
    14. Ren R, Hardikar S, Horton JR, Lu Y, Zeng Y, Singh AK, Lin K, Coletta LD, Shen J, Lin Kong CS, Hashimoto H, Zhang X, Chen T, Cheng X. Structural basis of specific DNA binding by the transcription factor ZBTB24. Nucleic Acids Res. 2019 09 19; 47(16):8388-8398. PMID: 31226215.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Woodcock CB, Yu D, Zhang X, Cheng X. Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112. Cell Discov. 2019; 5:50. PMID: 31632689.
      Citations: 7     
    16. Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X. Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun. 2019 08 06; 10(1):3541. PMID: 31388018.
      Citations: 5     Fields:    Translation:Cells
    17. Yang J, Horton JR, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for effects of CpA modifications on C/EBPß binding of DNA. Nucleic Acids Res. 2019 02 28; 47(4):1774-1785. PMID: 30566668.
      Citations: 2     Fields:    Translation:Cells
    18. Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X. Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J Med Chem. 2018 12 13; 61(23):10588-10601. PMID: 30392349.
      Citations: 3     Fields:    Translation:HumansCells
    19. Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X. Detecting and interpreting DNA methylation marks. Curr Opin Struct Biol. 2018 12; 53:88-99. PMID: 30031306.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    20. Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain. 2018 May; 159(5):884-893. PMID: 29369966.
      Citations: 10     Fields:    Translation:AnimalsCells
    21. Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X. Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. J Med Chem. 2018 04 12; 61(7):3193-3208. PMID: 29537847.
      Citations: 1     Fields:    Translation:HumansCells
    22. Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A. Epac1 interacts with importin ß1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370. PMID: 27808165.
      Citations: 4     Fields:    Translation:HumansCells
    23. Singhmar P, Huo X, Eijkelkamp N, Berciano SR, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Mayor F, Murga C, Heijnen CJ, Kavelaars A. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3036-41. PMID: 26929333.
      Citations: 34     Fields:    Translation:AnimalsCells
    24. Wayne CM, Fan HY, Cheng X, Richards JS. Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol. 2007 Aug; 21(8):1940-57. PMID: 17536007.
      Citations: 66     Fields:    Translation:AnimalsCells
    25. Structural basis for human PRDM9 action at recombination hot spots. Genes and Development. 30:257-265.
    26. DNA base flipping. Advances in Experimental Medicine and Biology. 945:321-341.
    27. Reply to Röglin et al. Proceedings of the National Academy of Sciences of the United States of America. 109.
    28. Hydration in protein crystals. A neutron diffraction analysis of carbonmonoxymyoglobin. Acta Crystallographica Section B. 46:195-208.
    29. 1 Protein methyltransferases. Enzymes. 24:3-22.
    30. Structural and functional consequences of circular permutation on the active site of Old Yellow Enzyme. ACS Catalysis. 5:892-899.
    31. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Research. 44:1642-1656.
    32. Retraction. Cell Research.
    33. Characterization of a linked jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases. Journal of Biological Chemistry. 291:2631-2646.
    34. Mechanisms of DNA methylation, methyl-CpG recognition, and demethylation in mammals. 9-24.
    35. Characterization of How DNA Modifications Affect DNA Binding by C2H2 Zinc Finger Proteins. 387-401.
    36. Defective heart development in hypomorphic LSD1 mice. Cell Research.
    37. JmjC lysine demethylases. 210-245.
    38. Acta Crystallographica Section A. 47:314-317.
    39. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell. 61:153-160.
    40. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chemical Biology. 23:769-781.
    41. Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science. 101.
    42. Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Research. 43:10713-10721.
    43. Oligonucleotides containing 5,6-dihydro-5-azacytosine at cpg sites can produce potent inhibition of dna cytosine-c5-methyltransferase without covalently binding to the enzyme. Antisense and Nucleic Acid Drug Development. 9:415-421.
    44. Errata to High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells [Cell Reports, 3 (2013) 567-576]. Cell Reports. 3:968.
    45. Methyl-lysine recognition by ankyrin-repeat proteins. 101-124.
    46. 4 Structure of protein arginine methyltransferases. Enzymes. 24:105-121.
    47. Structural and biochemical advances in mammalian DNA methylation. 85-100.
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