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XIAODONG CHENG

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou J, Chen T, Cheng X. One form and two functions: MBD of SETDB2 is a protein-interacting domain. Structure. 2024 Mar 07; 32(3):258-260. PMID: 38458157.
      Citations:    Fields:    Translation:Cells
    2. Zhang X, Xia F, Zhang X, Blumenthal RM, Cheng X, Xia F, Zhang X, Blumenthal RM. C2H2 Zinc Finger Transcription Factors Associated with Hemoglobinopathies. J Mol Biol. 2024 Apr 01; 436(7):168343. PMID: 37924864.
      Citations:    Fields:    Translation:HumansCells
    3. Yang J, Horton JR, Liu B, Corces VG, Blumenthal RM, Zhang X, Cheng X. Structures of CTCF-DNA complexes including all 11 zinc fingers. Nucleic Acids Res. 2023 09 08; 51(16):8447-8462. PMID: 37439339; PMCID: PMC10484683.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Zhou J, Horton JR, Kaur G, Chen Q, Li X, Mendoza F, Wu T, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural characterization of the first-discovered metazoan DNA cytosine-N4 methyltransferase from the bdelloid rotifer Adineta vaga. J Biol Chem. 2023 08; 299(8):105017. PMID: 37414145; PMCID: PMC10406627.
      Citations:    Fields:    Translation:AnimalsCells
    5. Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corr?a IR, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer. 2023 Jun; 5(2):zcad022. PMID: 37206360; PMCID: PMC10189803.
      Citations: 1     
    6. Kaur G, Ren R, Hammel M, Horton JR, Yang J, Cao Y, He C, Lan F, Lan X, Blobel GA, Blumenthal RM, Zhang X, Cheng X. Allosteric autoregulation of DNA binding via a DNA-mimicking protein domain: a biophysical study of ZNF410-DNA interaction using small angle X-ray scattering. Nucleic Acids Res. 2023 02 28; 51(4):1674-1686. PMID: 36660822; PMCID: PMC9976917.
      Citations:    Fields:    Translation:AnimalsCells
    7. Zhou J, Deng Y, Iyamu ID, Horton JR, Yu D, Hajian T, Vedadi M, Rotili D, Mai A, Blumenthal RM, Zhang X, Huang R, Cheng X. Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile-Specific DNA Adenine Methyltransferase. ACS Chem Biol. 2023 04 21; 18(4):734-745. PMID: 37082867; PMCID: PMC10127221.
      Citations:    Fields:    Translation:Cells
    8. Ren R, Horton JR, Chen Q, Yang J, Liu B, Huang Y, Blumenthal RM, Zhang X, Cheng X. Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia. J Biol Chem. 2023 02; 299(2):102885. PMID: 36626981; PMCID: PMC9932118.
      Citations:    Fields:    Translation:HumansCells
    9. Horton JR, Zhou J, Chen Q, Zhang X, Bedford MT, Cheng X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J Biol Chem. 2023 02; 299(2):102862. PMID: 36596360; PMCID: PMC9898751.
      Citations: 1     Fields:    Translation:Cells
    10. Zhou J, Horton JR, Menna M, Fiorentino F, Ren R, Yu D, Hajian T, Vedadi M, Mazzoccanti G, Ciogli A, Weinhold E, H?ben M, Blumenthal RM, Zhang X, Mai A, Rotili D, Cheng X. Systematic Design of Adenosine Analogs as Inhibitors of a Clostridioides difficile-Specific DNA Adenine Methyltransferase Required for Normal Sporulation and Persistence. J Med Chem. 2023 01 12; 66(1):934-950. PMID: 36581322; PMCID: PMC9841527.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Cheng X, Blumenthal RM. Mediating and maintaining methylation while minimizing mutation: Recent advances on mammalian DNA methyltransferases. Curr Opin Struct Biol. 2022 08; 75:102433. PMID: 35914495; PMCID: PMC9620438.
      Citations:    
    12. Yu D, Zhou J, Chen Q, Wu T, Blumenthal RM, Zhang X, Cheng X. Enzymatic Characterization of In Vitro Activity of RNA Methyltransferase PCIF1 on DNA. Biochemistry. 2022 May 23. PMID: 35605980; PMCID: PMC9178792.
      Citations:    Fields:    
    13. Horton JR, Pathuri S, Wong K, Ren R, Rueda L, Fosbenner DT, Heerding DA, McCabe MT, Pappalardi MB, Zhang X, King BW, Cheng X. Structural characterization of dicyanopyridine containing DNMT1-selective, non-nucleoside inhibitors. Structure. 2022 06 02; 30(6):793-802.e5. PMID: 35395178; PMCID: PMC9177618.
      Citations:    Fields:    Translation:Cells
    14. Yang J, Gupta E, Horton JR, Blumenthal RM, Zhang X, Cheng X. Differential ETS1 binding to T:G mismatches within a CpG dinucleotide contributes to C-to-T somatic mutation rate of the IDH2 hotspot at codon Arg140. DNA Repair (Amst). 2022 05; 113:103306. PMID: 35255310; PMCID: PMC9411267.
      Citations:    Fields:    
    15. Yu D, Dai N, Wolf EJ, Zhou J, Wu T, Blumenthal RM, Zhang X, Cheng X, Corr?a IR. Enzymatic characterization of mRNA cap adenosine-N6 methyltransferase PCIF1 activity on uncapped RNAs. J Biol Chem. 2022 04; 298(4):101751. PMID: 35189146; PMCID: PMC8931429.
      Citations: 1     Fields:    Translation:HumansCells
    16. Ren R, Horton JR, Hong S, Cheng X. Recent Advances on DNA Base Flipping: A General Mechanism for Writing, Reading, and Erasing DNA Modifications. Adv Exp Med Biol. 2022; 1389:295-315. PMID: 36350515; PMCID: PMC9711002.
      Citations:    Fields:    Translation:AnimalsCells
    17. Yu D, Horton JR, Yang J, Hajian T, Vedadi M, Sagum CA, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res. 2021 11 18; 49(20):11629-11642. PMID: 34086966; PMCID: PMC8599731.
      Citations: 6     Fields:    Translation:HumansCells
    18. Zhou J, Horton JR, Yu D, Ren R, Blumenthal RM, Zhang X, Cheng X. Repurposing epigenetic inhibitors to target the Clostridioides difficile-specific DNA adenine methyltransferase and sporulation regulator CamA. Epigenetics. 2022 09; 17(9):970-981. PMID: 34523387; PMCID: PMC9487755.
      Citations: 1     Fields:    
    19. Huang YH, Chen CW, Sundaramurthy V, Slabicki M, Hao D, Watson CJ, Tovy A, Reyes JM, Dakhova O, Crovetti BR, Galonska C, Lee M, Brunetti L, Zhou Y, Tatton-Brown K, Huang Y, Cheng X, Meissner A, Valk PJM, Sanders MA, Blundell JR, Li W, Ebert BL, Goodell MA, Van Maldergem L. Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor. Cancer Discov. 2022 01; 12(1):220-235. PMID: 34429321; PMCID: PMC8758508.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    20. Zhou J, Horton JR, Blumenthal RM, Zhang X, Cheng X. Clostridioides difficile specific DNA adenine methyltransferase CamA squeezes and flips adenine out of DNA helix. Nat Commun. 2021 06 08; 12(1):3436. PMID: 34103525; PMCID: PMC8187626.
      Citations: 2     Fields:    Translation:Cells
    21. Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem J. 2021 05 28; 478(10):1943-1958. PMID: 33969871; PMCID: PMC8166343.
      Citations:    Fields:    Translation:HumansCells
    22. Yang J, Horton JR, Akdemir KC, Li J, Huang Y, Kumar J, Blumenthal RM, Zhang X, Cheng X. Preferential CEBP binding to T:G mismatches and increased C-to-T human somatic mutations. Nucleic Acids Res. 2021 05 21; 49(9):5084-5094. PMID: 33877329; PMCID: PMC8136768.
      Citations:    Fields:    Translation:HumansCells
    23. Yu D, Kaur G, Blumenthal RM, Zhang X, Cheng X. Enzymatic characterization of three human RNA adenosine methyltransferases reveals diverse substrate affinities and reaction optima. J Biol Chem. 2021 Jan-Jun; 296:100270. PMID: 33428944; PMCID: PMC7948815.
      Citations: 4     Fields:    Translation:HumansCells
    24. Zhang X, Blumenthal RM, Cheng X. A Role for N6-Methyladenine in DNA Damage Repair. Trends Biochem Sci. 2021 03; 46(3):175-183. PMID: 33077363; PMCID: PMC7880869.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Woodcock CB, Horton JR, Zhang X, Blumenthal RM, Cheng X. Beta class amino methyltransferases from bacteria to humans: evolution and structural consequences. Nucleic Acids Res. 2020 10 09; 48(18):10034-10044. PMID: 32453412; PMCID: PMC7544214.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    26. Woodcock CB, Horton JR, Zhou J, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res. 2020 10 09; 48(18):10329-10341. PMID: 32663306; PMCID: PMC7544203.
      Citations: 9     Fields:    Translation:HumansCells
    27. Zeng Y, Ren R, Kaur G, Hardikar S, Ying Z, Babcock L, Gupta E, Zhang X, Chen T, Cheng X. The inactive Dnmt3b3 isoform preferentially enhances Dnmt3b-mediated DNA methylation. Genes Dev. 2020 11 01; 34(21-22):1546-1558. PMID: 33004415; PMCID: PMC7608744.
      Citations: 11     Fields:    Translation:AnimalsCells
    28. Kumar J, Kaur G, Ren R, Lu Y, Lin K, Li J, Huang Y, Patel A, Barton MC, Macfarlan T, Zhang X, Cheng X. KRAB domain of ZFP568 disrupts TRIM28-mediated abnormal interactions in cancer cells. NAR Cancer. 2020 Jun; 2(2):zcaa007. PMID: 32743551; PMCID: PMC7380489.
      Citations: 2     
    29. Hardikar S, Ying Z, Zeng Y, Zhao H, Liu B, Veland N, McBride K, Cheng X, Chen T. The ZBTB24-CDCA7 axis regulates HELLS enrichment at centromeric satellite repeats to facilitate DNA methylation. Protein Cell. 2020 03; 11(3):214-218. PMID: 31970665; PMCID: PMC7026229.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    30. Horton JR, Yang J, Zhang X, Petronzio T, Fomenkov A, Wilson GG, Roberts RJ, Cheng X. Structure of HhaI endonuclease with cognate DNA at an atomic resolution of 1.0 ?. Nucleic Acids Res. 2020 02 20; 48(3):1466-1478. PMID: 31879785; PMCID: PMC7026639.
      Citations:    Fields:    Translation:Cells
    31. Woodcock CB, Yu D, Hajian T, Li J, Huang Y, Dai N, Wu T, Vedadi M, Zhang X, Cheng X, Corr?a IR. Human MettL3-MettL14 complex is a sequence-specific DNA adenine methyltransferase active on single-strand and unpaired DNA in vitro. Cell Discov. 2019; 5:63. PMID: 31885874; PMCID: PMC6928010.
      Citations: 21     
    32. Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev. 2019 12 01; 33(23-24):1702-1717. PMID: 31699778; PMCID: PMC6942045.
      Citations: 9     Fields:    Translation:HumansCells
    33. Yang J, Zhang X, Blumenthal RM, Cheng X. Detection of DNA Modifications by Sequence-Specific Transcription Factors. J Mol Biol. 2020 Mar 13; 432(6):1661-1673. PMID: 31626807; PMCID: PMC7156337.
      Citations: 4     Fields:    
    34. Horton JR, Woodcock CB, Opot SB, Reich NO, Zhang X, Cheng X. The cell cycle-regulated DNA adenine methyltransferase CcrM opens a bubble at its DNA recognition site. Nat Commun. 2019 10 10; 10(1):4600. PMID: 31601797; PMCID: PMC6787082.
      Citations: 10     Fields:    Translation:Cells
    35. Yang J, Horton JR, Li J, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for preferential binding of human TCF4 to DNA containing 5-carboxylcytosine. Nucleic Acids Res. 2019 09 19; 47(16):8375-8387. PMID: 31081034; PMCID: PMC6895265.
      Citations: 11     Fields:    Translation:HumansCells
    36. Ren R, Hardikar S, Horton JR, Lu Y, Zeng Y, Singh AK, Lin K, Coletta LD, Shen J, Lin Kong CS, Hashimoto H, Zhang X, Chen T, Cheng X. Structural basis of specific DNA binding by the transcription factor ZBTB24. Nucleic Acids Res. 2019 09 19; 47(16):8388-8398. PMID: 31226215; PMCID: PMC6895263.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    37. Woodcock CB, Yu D, Zhang X, Cheng X. Human HemK2/KMT9/N6AMT1 is an active protein methyltransferase, but does not act on DNA in vitro, in the presence of Trm112. Cell Discov. 2019; 5:50. PMID: 31632689; PMCID: PMC6796829.
      Citations: 18     
    38. Dai S, Horton JR, Woodcock CB, Wilkinson AW, Zhang X, Gozani O, Cheng X. Structural basis for the target specificity of actin histidine methyltransferase SETD3. Nat Commun. 2019 08 06; 10(1):3541. PMID: 31388018; PMCID: PMC6684798.
      Citations: 9     Fields:    Translation:Cells
    39. Yang J, Horton JR, Wang D, Ren R, Li J, Sun D, Huang Y, Zhang X, Blumenthal RM, Cheng X. Structural basis for effects of CpA modifications on C/EBP? binding of DNA. Nucleic Acids Res. 2019 02 28; 47(4):1774-1785. PMID: 30566668; PMCID: PMC6393304.
      Citations: 9     Fields:    Translation:Cells
    40. Horton JR, Woodcock CB, Chen Q, Liu X, Zhang X, Shanks J, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Cyr M, Pohida K, Hu X, Shah P, Xu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Cheng X. Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A. J Med Chem. 2018 12 13; 61(23):10588-10601. PMID: 30392349; PMCID: PMC6467790.
      Citations: 4     Fields:    Translation:HumansCells
    41. Ren R, Horton JR, Zhang X, Blumenthal RM, Cheng X. Detecting and interpreting DNA methylation marks. Curr Opin Struct Biol. 2018 12; 53:88-99. PMID: 30031306; PMCID: PMC6322410.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    42. Singhmar P, Huo X, Li Y, Dougherty PM, Mei F, Cheng X, Heijnen CJ, Kavelaars A. Orally active Epac inhibitor reverses mechanical allodynia and loss of intraepidermal nerve fibers in a mouse model of chemotherapy-induced peripheral neuropathy. Pain. 2018 May; 159(5):884-893. PMID: 29369966; PMCID: PMC5908748.
      Citations: 22     Fields:    Translation:AnimalsCells
    43. Horton JR, Liu X, Wu L, Zhang K, Shanks J, Zhang X, Rai G, Mott BT, Jansen DJ, Kales SC, Henderson MJ, Pohida K, Fang Y, Hu X, Jadhav A, Maloney DJ, Hall MD, Simeonov A, Fu H, Vertino PM, Yan Q, Cheng X. Insights into the Action of Inhibitor Enantiomers against Histone Lysine Demethylase 5A. J Med Chem. 2018 04 12; 61(7):3193-3208. PMID: 29537847; PMCID: PMC6322411.
      Citations: 3     Fields:    Translation:HumansCells
    44. Baameur F, Singhmar P, Zhou Y, Hancock JF, Cheng X, Heijnen CJ, Kavelaars A. Epac1 interacts with importin ?1 and controls neurite outgrowth independently of cAMP and Rap1. Sci Rep. 2016 11 03; 6:36370. PMID: 27808165; PMCID: PMC5093460.
      Citations: 9     Fields:    Translation:HumansCells
    45. Singhmar P, Huo X, Eijkelkamp N, Baameur F, Mei FC, Zhu Y, Cheng X, Hawke D, Heijnen CJ, Kavelaars A, Berciano SR, Mayor F, Murga C. Critical role for Epac1 in inflammatory pain controlled by GRK2-mediated phosphorylation of Epac1. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3036-41. PMID: 26929333; PMCID: PMC4801297.
      Citations: 56     Fields:    Translation:AnimalsCells
    46. Wayne CM, Fan HY, Cheng X, Richards JS. Follicle-stimulating hormone induces multiple signaling cascades: evidence that activation of Rous sarcoma oncogene, RAS, and the epidermal growth factor receptor are critical for granulosa cell differentiation. Mol Endocrinol. 2007 Aug; 21(8):1940-57. PMID: 17536007.
      Citations: 75     Fields:    Translation:AnimalsCells
    47. Structural basis for human PRDM9 action at recombination hot spots. Genes and Development. 30:257-265.
    48. DNA base flipping. Advances in Experimental Medicine and Biology. 945:321-341.
    49. Reply to Röglin et al. Proceedings of the National Academy of Sciences of the United States of America. 109.
    50. Hydration in protein crystals. A neutron diffraction analysis of carbonmonoxymyoglobin. Acta Crystallographica Section B. 46:195-208.
    51. 1 Protein methyltransferases. Enzymes. 24:3-22.
    52. Structural and functional consequences of circular permutation on the active site of Old Yellow Enzyme. ACS Catalysis. 5:892-899.
    53. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Research. 44:1642-1656.
    54. Retraction. Cell Research.
    55. Characterization of a linked jumonji domain of the KDM5/JARID1 family of histone H3 lysine 4 demethylases. Journal of Biological Chemistry. 291:2631-2646.
    56. Mechanisms of DNA methylation, methyl-CpG recognition, and demethylation in mammals. 9-24.
    57. Characterization of How DNA Modifications Affect DNA Binding by C2H2 Zinc Finger Proteins. 387-401.
    58. Defective heart development in hypomorphic LSD1 mice. Cell Research.
    59. JmjC lysine demethylases. 210-245.
    60. Acta Crystallographica Section A. 47:314-317.
    61. Lin28A Binds Active Promoters and Recruits Tet1 to Regulate Gene Expression. Molecular Cell. 61:153-160.
    62. Structural Basis for KDM5A Histone Lysine Demethylase Inhibition by Diverse Compounds. Cell Chemical Biology. 23:769-781.
    63. Progress in Molecular Biology and Translational Science. Progress in Molecular Biology and Translational Science. 101.
    64. Structure of Naegleria Tet-like dioxygenase (NgTet1) in complexes with a reaction intermediate 5-hydroxymethylcytosine DNA. Nucleic Acids Research. 43:10713-10721.
    65. Oligonucleotides containing 5,6-dihydro-5-azacytosine at cpg sites can produce potent inhibition of dna cytosine-c5-methyltransferase without covalently binding to the enzyme. Antisense and Nucleic Acid Drug Development. 9:415-421.
    66. Errata to High-resolution enzymatic mapping of genomic 5-hydroxymethylcytosine in mouse embryonic stem cells [Cell Reports, 3 (2013) 567-576]. Cell Reports. 3:968.
    67. Methyl-lysine recognition by ankyrin-repeat proteins. 101-124.
    68. 4 Structure of protein arginine methyltransferases. Enzymes. 24:105-121.
    69. Structural and biochemical advances in mammalian DNA methylation. 85-100.
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