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ANDREW RHIM

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGastroenterology Hepatology & Nutrition
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wang L, Yang H, Zamperone A, Diolaiti D, Palmbos PL, Abel EV, Purohit V, Dolgalev I, Rhim AD, Ljungman M, Hadju CH, Halbrook CJ, Bar-Sagi D, di Magliano MP, Crawford HC, Simeone DM. ATDC is required for the initiation of KRAS-induced pancreatic tumorigenesis. Genes Dev. 2019 Jun 01; 33(11-12):641-655. PMID: 31048544.
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    2. Brown JC, Rhim AD, Manning SL, Brennan L, Mansour AI, Rustgi AK, Damjanov N, Troxel AB, Rickels MR, Ky B, Zemel BS, Courneya KS, Schmitz KH. Effects of exercise on circulating tumor cells among patients with resected stage I-III colon cancer. PLoS One. 2018; 13(10):e0204875. PMID: 30332430.
      View in: PubMed
    3. Reichert M, Bakir B, Moreira L, Pitarresi JR, Feldmann K, Simon L, Suzuki K, Maddipati R, Rhim AD, Schlitter AM, Kriegsmann M, Weichert W, Wirth M, Schuck K, Schneider G, Saur D, Reynolds AB, Klein-Szanto AJ, Pehlivanoglu B, Memis B, Adsay NV, Rustgi AK. Regulation of Epithelial Plasticity Determines Metastatic Organotropism in Pancreatic Cancer. Dev Cell. 2018 06 18; 45(6):696-711.e8. PMID: 29920275.
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    4. Brown JC, Damjanov N, Courneya KS, Troxel AB, Zemel BS, Rickels MR, Ky B, Rhim AD, Rustgi AK, Schmitz KH. A randomized dose-response trial of aerobic exercise and health-related quality of life in colon cancer survivors. Psychooncology. 2018 04; 27(4):1221-1228. PMID: 29388275.
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    5. Kopp JL, Dubois CL, Schaeffer DF, Samani A, Taghizadeh F, Cowan RW, Rhim AD, Stiles BL, Valasek M, Sander M. Loss of Pten and Activation of Kras Synergistically Induce Formation of Intraductal Papillary Mucinous Neoplasia From Pancreatic Ductal Cells in Mice. Gastroenterology. 2018 04; 154(5):1509-1523.e5. PMID: 29273451.
      View in: PubMed
    6. Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC. MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance. Nat Commun. 2017 11 23; 8(1):1728. PMID: 29170413.
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    7. Brown JC, Rickels MR, Troxel AB, Zemel BS, Damjanov N, Ky B, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH. Dose-response effects of exercise on insulin among colon cancer survivors. Endocr Relat Cancer. 2018 01; 25(1):11-19. PMID: 29018055.
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    8. Brown JC, Zemel BS, Troxel AB, Rickels MR, Damjanov N, Ky B, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH. Dose-response effects of aerobic exercise on body composition among colon cancer survivors: a randomised controlled trial. Br J Cancer. 2017 Nov 21; 117(11):1614-1620. PMID: 28934762.
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    9. Parkin B, Londoño-Joshi A, Kang Q, Tewari M, Rhim AD, Malek SN. Ultrasensitive mutation detection identifies rare residual cells causing acute myelogenous leukemia relapse. J Clin Invest. 2017 Sep 01; 127(9):3484-3495. PMID: 28825596.
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    10. Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH. Dose-response Effects of Aerobic Exercise Among Colon Cancer Survivors: A Randomized Phase II Trial. Clin Colorectal Cancer. 2018 03; 17(1):32-40. PMID: 28669606.
      View in: PubMed
    11. Lutz MP, Zalcberg JR, Ducreux M, Aust D, Bruno MJ, Büchler MW, Delpero JR, Gloor B, Glynne-Jones R, Hartwig W, Huguet F, Laurent-Puig P, Lordick F, Maisonneuve P, Mayerle J, Martignoni M, Neoptolemos J, Rhim AD, Schmied BM, Seufferlein T, Werner J, van Laethem JL, Otto F. 3rd St. Gallen EORTC Gastrointestinal Cancer Conference: Consensus recommendations on controversial issues in the primary treatment of pancreatic cancer. Eur J Cancer. 2017 07; 79:41-49. PMID: 28460245.
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    12. Agarwalla A, Weber A, Davey S, Hamilton K, Goldberg D, Rhim AD, Yang YX. Lactulose Is Associated With Decreased Risk of Clostridium difficile Infection in Decompensated Cirrhosis. Clin Gastroenterol Hepatol. 2017 06; 15(6):953-954. PMID: 28126426.
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    13. Boursi B, Finkelman B, Giantonio BJ, Haynes K, Rustgi AK, Rhim AD, Mamtani R, Yang YX. A Clinical Prediction Model to Assess Risk for Pancreatic Cancer Among Patients With New-Onset Diabetes. Gastroenterology. 2017 03; 152(4):840-850.e3. PMID: 27923728.
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    14. Abou-Alfa GK, Andersen JB, Chapman W, Choti M, Forbes SJ, Gores GJ, Hong TS, Harding JJ, Vander Heiden MG, Javle M, Kelley RK, Kwong LN, Lowery M, Merrell A, Miyabe K, Rhim A, Saha S, Sia D, Tanasanvimon S, Venook A, Valle JW, Walesky C, Whetstine J, Willenbring H, Zhu AX, Mayer D, Stanger BZ. Advances in cholangiocarcinoma research: report from the third Cholangiocarcinoma Foundation Annual Conference. J Gastrointest Oncol. 2016 Dec; 7(6):819-827. PMID: 28078106.
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    15. Saloman JL, Albers KM, Rhim AD, Davis BM. Can Stopping Nerves, Stop Cancer? Trends Neurosci. 2016 12; 39(12):880-889. PMID: 27832915.
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    16. Miller MS, Allen P, Brentnall TA, Goggins M, Hruban RH, Petersen GM, Rao CV, Whitcomb DC, Brand RE, Chari ST, Klein AP, Lubman DM, Rhim AD, Simeone DM, Wolpin BM, Umar A, Srivastava S, Steele VE, Rinaudo JA. Pancreatic Cancer Chemoprevention Translational Workshop: Meeting Report. Pancreas. 2016 09; 45(8):1080-91. PMID: 27518363.
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    17. Zhang Y, Velez-Delgado A, Mathew E, Li D, Mendez FM, Flannagan K, Rhim AD, Simeone DM, Beatty GL, Pasca di Magliano M. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017 01; 66(1):124-136. PMID: 27402485.
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    18. Meyer KA, Neeley CK, Baker NA, Washabaugh AR, Flesher CG, Nelson BS, Frankel TL, Lumeng CN, Lyssiotis CA, Wynn ML, Rhim AD, O'Rourke RW. Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer. Biochem Biophys Rep. 2016 Sep; 7:144-149. PMID: 27617308.
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    19. Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH. A randomized phase II dose-response exercise trial among colon cancer survivors: Purpose, study design, methods, and recruitment results. Contemp Clin Trials. 2016 Mar; 47:366-75. PMID: 26970181.
      View in: PubMed
    20. Saloman JL, Albers KM, Li D, Hartman DJ, Crawford HC, Muha EA, Rhim AD, Davis BM. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proc Natl Acad Sci U S A. 2016 Mar 15; 113(11):3078-83. PMID: 26929329.
      View in: PubMed
    21. Aiello NM, Rhim AD, Stanger BZ. Isolating Epithelial and Epithelial-to-Mesenchymal Transition Populations from Primary Tumors by Fluorescence-Activated Cell Sorting. Cold Spring Harb Protoc. 2016 Jan 04; 2016(1):pdb.prot078352. PMID: 26729901.
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    22. Aiello NM, Rhim AD, Stanger BZ. Orthotopic Injection of Pancreatic Cancer Cells. Cold Spring Harb Protoc. 2016 Jan 04; 2016(1):pdb.prot078360. PMID: 26729902.
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    23. Roberts NJ, Norris AL, Petersen GM, Bondy ML, Brand R, Gallinger S, Kurtz RC, Olson SH, Rustgi AK, Schwartz AG, Stoffel E, Syngal S, Zogopoulos G, Ali SZ, Axilbund J, Chaffee KG, Chen YC, Cote ML, Childs EJ, Douville C, Goes FS, Herman JM, Iacobuzio-Donahue C, Kramer M, Makohon-Moore A, McCombie RW, McMahon KW, Niknafs N, Parla J, Pirooznia M, Potash JB, Rhim AD, Smith AL, Wang Y, Wolfgang CL, Wood LD, Zandi PP, Goggins M, Karchin R, Eshleman JR, Papadopoulos N, Kinzler KW, Vogelstein B, Hruban RH, Klein AP. Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer. Cancer Discov. 2016 Feb; 6(2):166-75. PMID: 26658419.
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    24. Cowan RW, Maitra A, Rhim AD. A New Scalpel for the Treatment of Pancreatic Cancer: Targeting Stromal-Derived STAT3 Signaling. Gastroenterology. 2015 Dec; 149(7):1685-8. PMID: 26526714.
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    25. Chari ST, Kelly K, Hollingsworth MA, Thayer SP, Ahlquist DA, Andersen DK, Batra SK, Brentnall TA, Canto M, Cleeter DF, Firpo MA, Gambhir SS, Go VL, Hines OJ, Kenner BJ, Klimstra DS, Lerch MM, Levy MJ, Maitra A, Mulvihill SJ, Petersen GM, Rhim AD, Simeone DM, Srivastava S, Tanaka M, Vinik AI, Wong D. Early detection of sporadic pancreatic cancer: summative review. Pancreas. 2015 Jul; 44(5):693-712. PMID: 25931254.
      View in: PubMed
    26. Rhim AD, Jechlinger M, Rustgi AK. Culturing mouse tumor cells. Cold Spring Harb Protoc. 2015 Jun 01; 2015(6):505-7. PMID: 26034311.
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    27. Reichert M, Rhim AD, Rustgi AK. Culturing primary mouse pancreatic ductal cells. Cold Spring Harb Protoc. 2015 Jun 01; 2015(6):558-61. PMID: 26034301.
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    28. Rhim AD. Creation of primary cell lines from lineage-labeled mouse models of cancer. Cold Spring Harb Protoc. 2015 May 01; 2015(5):453-6. PMID: 25934932.
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    29. Rhim AD, Rustgi AK. Three-dimensional organotypic culture of stratified epithelia. Cold Spring Harb Protoc. 2015 Apr 01; 2015(4):349-53. PMID: 25834261.
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    30. Qu D, Johnson J, Chandrakesan P, Weygant N, May R, Aiello N, Rhim A, Zhao L, Zheng W, Lightfoot S, Pant S, Irvan J, Postier R, Hocker J, Hanas JS, Ali N, Sureban SM, An G, Schlosser MJ, Stanger B, Houchen CW. Doublecortin-like kinase 1 is elevated serologically in pancreatic ductal adenocarcinoma and widely expressed on circulating tumor cells. PLoS One. 2015; 10(2):e0118933. PMID: 25723399.
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    31. Wang L, Yang H, Abel EV, Ney GM, Palmbos PL, Bednar F, Zhang Y, Leflein J, Waghray M, Owens S, Wilkinson JE, Prasad J, Ljungman M, Rhim AD, Pasca di Magliano M, Simeone DM. ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis. Genes Dev. 2015 Jan 15; 29(2):171-83. PMID: 25593307.
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    32. Sreekumar BK, Belinsky GS, Einwachter H, Rhim AD, Schmid R, Chung C. Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions. Pancreas. 2014 Nov; 43(8):1256-63. PMID: 25072283.
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    33. Coleman SJ, Rhim AD. Molecular biology of pancreatic ductal adenocarcinoma. Curr Opin Gastroenterol. 2014 Sep; 30(5):506-10. PMID: 25023382.
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    34. Huang C, Smith JP, Saha TN, Rhim AD, Kirby BJ. Characterization of microfluidic shear-dependent epithelial cell adhesion molecule immunocapture and enrichment of pancreatic cancer cells from blood cells with dielectrophoresis. Biomicrofluidics. 2014 Jul; 8(4):044107. PMID: 25379092.
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    35. Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Barrena MG, Fernandez-Zapico ME, Iacobuzio-Donahue C, Olive KP, Stanger BZ. Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. Cancer Cell. 2014 Jun 16; 25(6):735-47. PMID: 24856585.
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    36. Shah P, Rhim AD, Haynes K, Hwang WT, Yang YX. Diagnosis of pernicious anemia and the risk of pancreatic cancer. Pancreas. 2014 Apr; 43(3):422-6. PMID: 24622073.
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    37. Thege FI, Lannin TB, Saha TN, Tsai S, Kochman ML, Hollingsworth MA, Rhim AD, Kirby BJ. Microfluidic immunocapture of circulating pancreatic cells using parallel EpCAM and MUC1 capture: characterization, optimization and downstream analysis. Lab Chip. 2014 May 21; 14(10):1775-84. PMID: 24681997.
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    38. Stopczynski RE, Normolle DP, Hartman DJ, Ying H, DeBerry JJ, Bielefeldt K, Rhim AD, DePinho RA, Albers KM, Davis BM. Neuroplastic changes occur early in the development of pancreatic ductal adenocarcinoma. Cancer Res. 2014 Mar 15; 74(6):1718-27. PMID: 24448244.
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    39. Rhim AD, Thege FI, Santana SM, Lannin TB, Saha TN, Tsai S, Maggs LR, Kochman ML, Ginsberg GG, Lieb JG, Chandrasekhara V, Drebin JA, Ahmad N, Yang YX, Kirby BJ, Stanger BZ. Detection of circulating pancreas epithelial cells in patients with pancreatic cystic lesions. Gastroenterology. 2014 Mar; 146(3):647-51. PMID: 24333829.
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    40. Helgadóttir H, Metz DC, Yang YX, Rhim AD, Björnsson ES. The effects of long-term therapy with proton pump inhibitors on meal stimulated gastrin. Dig Liver Dis. 2014 Feb; 46(2):125-30. PMID: 24210828.
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    41. Zhang Y, Yan W, Collins MA, Bednar F, Rakshit S, Zetter BR, Stanger BZ, Chung I, Rhim AD, di Magliano MP. Interleukin-6 is required for pancreatic cancer progression by promoting MAPK signaling activation and oxidative stress resistance. Cancer Res. 2013 Oct 15; 73(20):6359-74. PMID: 24097820.
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    42. Kim J, Hoffman JP, Alpaugh RK, Rhim AD, Rhimm AD, Reichert M, Stanger BZ, Furth EE, Sepulveda AR, Yuan CX, Won KJ, Donahue G, Sands J, Gumbs AA, Zaret KS. An iPSC line from human pancreatic ductal adenocarcinoma undergoes early to invasive stages of pancreatic cancer progression. Cell Rep. 2013 Jun 27; 3(6):2088-99. PMID: 23791528.
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    43. Hamilton KE, Noubissi FK, Katti PS, Hahn CM, Davey SR, Lundsmith ET, Klein-Szanto AJ, Rhim AD, Spiegelman VS, Rustgi AK. IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts. Carcinogenesis. 2013 Nov; 34(11):2647-54. PMID: 23764754.
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    44. Reichert M, Takano S, von Burstin J, Kim SB, Lee JS, Ihida-Stansbury K, Hahn C, Heeg S, Schneider G, Rhim AD, Stanger BZ, Rustgi AK. The Prrx1 homeodomain transcription factor plays a central role in pancreatic regeneration and carcinogenesis. Genes Dev. 2013 Feb 01; 27(3):288-300. PMID: 23355395.
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    45. Rhim AD. Epithelial to mesenchymal transition and the generation of stem-like cells in pancreatic cancer. Pancreatology. 2013 Mar-Apr; 13(2):114-7. PMID: 23561968.
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    46. Bayne LJ, Beatty GL, Jhala N, Clark CE, Rhim AD, Stanger BZ, Vonderheide RH. Tumor-derived granulocyte-macrophage colony-stimulating factor regulates myeloid inflammation and T cell immunity in pancreatic cancer. Cancer Cell. 2012 Jun 12; 21(6):822-35. PMID: 22698406.
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    47. Rhim AD, Mirek ET, Aiello NM, Maitra A, Bailey JM, McAllister F, Reichert M, Beatty GL, Rustgi AK, Vonderheide RH, Leach SD, Stanger BZ. EMT and dissemination precede pancreatic tumor formation. Cell. 2012 Jan 20; 148(1-2):349-61. PMID: 22265420.
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    48. Rhim AD, Stanger BZ. Molecular biology of pancreatic ductal adenocarcinoma progression: aberrant activation of developmental pathways. Prog Mol Biol Transl Sci. 2010; 97:41-78. PMID: 21074729.
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    49. Rhim AD. A combined, rational approach towards inhibition of the MEK-ERK and mTOR pathways in pancreatic ductal adenocarcinoma: promise or deja vu? Cancer Biol Ther. 2009 Oct; 8(20):1902-3. PMID: 19783905.
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    50. Plentz R, Park JS, Rhim AD, Abravanel D, Hezel AF, Sharma SV, Gurumurthy S, Deshpande V, Kenific C, Settleman J, Majumder PK, Stanger BZ, Bardeesy N. Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. Gastroenterology. 2009 May; 136(5):1741-9.e6. PMID: 19208345.
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    51. Rhim AD, Kochman ML. A young woman with gallstone pancreatitis and abnormal liver tests: when is endoscopic retrograde cholangiopancreatography needed? Clin Gastroenterol Hepatol. 2008 Jul; 6(7):741-5. PMID: 18547871.
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    52. Pazianas M, Rhim AD, Weinberg AM, Su C, Lichtenstein GR. The effect of anti-TNF-alpha therapy on spinal bone mineral density in patients with Crohn's disease. Ann N Y Acad Sci. 2006 Apr; 1068:543-56. PMID: 16831950.
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    53. Campbell MS, Lichtenstein GR, Rhim AD, Pazianas M, Faust T. Severity of liver disease does not predict osteopenia or low bone mineral density in primary sclerosing cholangitis. Liver Int. 2005 Apr; 25(2):311-6. PMID: 15780055.
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    54. Rhim AD, Stoykova LI, Trindade AJ, Glick MC, Scanlin TF. Altered terminal glycosylation and the pathophysiology of CF lung disease. J Cyst Fibros. 2004 Aug; 3 Suppl 2:95-6. PMID: 15463936.
      View in: PubMed
    55. Advances in cholangiocarcinoma research. Journal of Gastrointestinal Oncology. 7:819-827.
    56. Ablation of sensory neurons in a genetic model of pancreatic ductal adenocarcinoma slows initiation and progression of cancer. Proceedings of the National Academy of Sciences of the United States of America. 113:3078-3083.
    57. The glycobiology of cystic fibrosis. Current Organic Chemistry. 8:385-394.
    58. Isolating epithelial and epithelial-to-mesenchymal transition populations from primary tumors by fluorescence-activated cell sorting. Cold Spring Harbor Protocols. 2016:34-37.
    59. Whole genome sequencing defines the genetic heterogeneity of familial pancreatic cancer. Cancer Discovery. 6:166-175.
    60. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut.
    61. Adipocytes promote pancreatic cancer cell proliferation via glutamine transfer. Biochemistry and Biophysics Reports. 7:144-149.
    62. Creation of primary cell lines from lineage-labeled mouse models of cancer. Cold Spring Harbor Protocols. 2015:453-456.
    63. Early Detection of Sporadic Pancreatic Cancer. Pancreas. 44:693-712.
    64. Microfluidic capture of circulating pancreatic cells for detection of biomarkers for carcinogenesis in patients with pancreatic cyst lesions. 597-599.
    65. Polarization of the vacuolar adenosine triphosphatase delineates a transition to high-grade pancreatic intraepithelial neoplasm lesions. Pancreas.
    66. Parallelized microfluidic immuno capture of circulating pancreatic cells for genetic analysis and early detection of pancreatic carcinogenesis. 20-22.
    67. Contemporary Clinical Trials. 47:366-375.
    68. Can Stopping Nerves, Stop Cancer?. Trends in Neurosciences. 39:880-889.
    69. Orthotopic injection of pancreatic cancer cells. Cold Spring Harbor Protocols. 2016:37-40.
    70. Pancreatic Cancer Chemoprevention Translational Workshop. Pancreas. 45:1080-1091.
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