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ONDREJ HAVRANEK

TitleInstructor
InstitutionMD Anderson
DepartmentLymphoma-Myeloma
Address7455 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kupcova K, Senavova J, Jura F, Herman V, Rajmonova A, Pacheco-Blanco M, Chrbolkova T, Hamova I, Davis RE, Havranek O. Vertical targeting of the PI3K/AKT pathway at multiple points is synergistic and effective for non-Hodgkin lymphoma. Exp Hematol Oncol. 2024 Nov 01; 13(1):108. PMID: 39487517; PMCID: PMC11529427.
      Citations:    
    2. Bettazov? N, Senavova J, Kupcova K, Sovilj D, Rejmonova A, Andera L, Svobodov? K, Berkova A, Zemanova Z, Daumova L, Herman V, Dolnikova A, Davis RE, Trnen? M, Klener P, Havranek O, Bettazova N, Senavova J, Kupcova K, Sovilj D, Rajmonova A, Andera L, Svobodova K, Berkova A, Zemanova Z, Daumova L, Herman V, Doln?kova A, Davis RE, Trneny M, Klener P, Havranek O. Impact of PIK3CA gain and PTEN loss on mantle cell lymphoma biology and sensitivity to targeted therapies. Blood Adv. 2024 10 22; 8(20):5279-5289. PMID: 39158100; PMCID: PMC11497468.
      Citations:    Fields:    Translation:HumansCells
    3. Soukupova J, Stastna B, Kanwal M, Hojny J, Zemankova P, Borecka M, Cerna L, Cerna M, Cerna M, Curtisova V, Dolezalova T, Duskova P, Foretova L, Havranek O, Horackova K, Hovhannisyan M, Hruskova L, Chvojka S, Janatova M, Janikova M, Jelinkova S, Just P, Kalousova M, Kleiblova P, Kosarova M, Koudova M, Kral J, Krausova M, Krutilkova V, Machackova E, Matejkova K, Michalovska R, Nehasil P, Nemcova B, Novotny J, Palek M, Pesek P, Safarikova M, Scheinost O, Springer D, Stolarova L, Stranecky V, Subrt I, Tavandzis S, Tureckova E, Vesela K, Vlckova Z, Vocka M, Zima T, Macurek L, Kleibl Z, CZECANCA consortium. A comprehensive study evaluating germline FANCG variants in predisposition to breast and ovarian cancer. Cancer Med. 2024 Aug; 13(16):e70103. PMID: 39149814; PMCID: PMC11327753.
      Citations: 1     Fields:    Translation:HumansCells
    4. Malarikova D, Jorda R, Kupcova K, Senavova J, Dolnikova A, Pokorna E, Kazantsev D, Nozickova K, Sovilj D, Bellanger C, Chiron D, Andera L, Krystof V, Strnad M, Helman K, Klanova M, Trneny M, Havranek O, Klener P. Cyclin dependent kinase 4/6 inhibitor palbociclib synergizes with BCL2 inhibitor venetoclax in experimental models of mantle cell lymphoma without RB1 deletion. Exp Hematol Oncol. 2024 Mar 25; 13(1):34. PMID: 38528594; PMCID: PMC10962182.
      Citations: 1     
    5. Zemankova P, Cerna M, Horackova K, Ernst C, Soukupova J, Borecka M, Bl?mcke B, Cerna L, Cerna M, Curtisova V, Dolezalova T, Duskova P, Dvorakova L, Foretova L, Havranek O, Hauke J, Hahnen E, Hodulova M, Hovhannisyan M, Hruskova L, Janatova M, Janikova M, Jelinkova S, Just P, Kosarova M, Koudova M, Krutilkova V, Machackova E, Matejkova K, Michalovska R, Misove A, Nehasil P, Nemcova B, Novotny J, Panczak A, Pesek P, Scheinost O, Springer D, Stastna B, Stranecky V, Subrt I, Tavandzis S, Tureckova E, Vesela K, Vlckova Z, Vocka M, Wappenschmidt B, Zima T, Kleibl Z, Kleiblova P. A deep intronic recurrent CHEK2 variant c.1009-118_1009-87delinsC affects pre-mRNA splicing and contributes to hereditary breast cancer predisposition. Breast. 2024 Jun; 75:103721. PMID: 38554551; PMCID: PMC10998186.
      Citations: 2     Fields:    Translation:HumansCells
    6. Eken JA, Koning MT, Kupcova K, Sep?lveda Y??ez JH, de Groen RAL, Quinten E, Janssen J, van Bergen CAM, Vermaat JSP, Cleven A, Navarrete MA, Ylstra B, de Jong D, Havranek O, Jumaa H, Veelken H. Antigen-independent, autonomous B cell receptor signaling drives activated B cell DLBCL. J Exp Med. 2024 May 06; 221(5). PMID: 38512136; PMCID: PMC10959178.
      Citations: 3     Fields:    Translation:AnimalsCells
    7. Tkachenko A, Havranek O. Erythronecroptosis: an overview of necroptosis or programmed necrosis in red blood cells. Mol Cell Biochem. 2024 Dec; 479(12):3273-3291. PMID: 38427167.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Tkachenko A, Kupcova K, Havranek O. B-Cell Receptor Signaling and Beyond: The Role of Iga (CD79a)/Ig? (CD79b) in Normal and Malignant B Cells. Int J Mol Sci. 2023 Dec 19; 25(1). PMID: 38203179; PMCID: PMC10779339.
      Citations: 15     Fields:    Translation:Cells
    9. Tkachenko A, Onishchenko A, Myasoedov V, Yefimova S, Havranek O. Assessing regulated cell death modalities as an efficient tool for in?vitro nanotoxicity screening: a review. Nanotoxicology. 2023 04; 17(3):218-248. PMID: 37083543.
      Citations:    Fields:    Translation:Humans
    10. Kral J, Jelinkova S, Zemankova P, Vocka M, Borecka M, Cerna L, Cerna M, Dostalek L, Duskova P, Foretova L, Havranek O, Horackova K, Hovhannisyan M, Chvojka S, Kalousova M, Kosarova M, Koudova M, Krutilkova V, Machackova E, Nehasil P, Novotny J, Otahalova B, Puchmajerova A, Safarikova M, Slama J, Stranecky V, Subrt I, Tavandzis S, Zikan M, Zima T, Soukupova J, Kleiblova P, Kleibl Z, Janatova M. Germline multigene panel testing of patients with endometrial cancer. Oncol Lett. 2023 Jun; 25(6):216. PMID: 37153042; PMCID: PMC10157349.
      Citations:    
    11. Maco M, Kupcova K, Herman V, Ondeckova I, Kozak T, Mocikova H, Havranek O, Czech Hodgkin Lymphoma Study Group. Circulating tumor DNA in Hodgkin lymphoma. Ann Hematol. 2022 Nov; 101(11):2393-2403. PMID: 36074181; PMCID: PMC9546971.
      Citations:    
    12. Klanova M, Kazantsev D, Pokorna E, Zikmund T, Karolova J, Behounek M, Renesova N, Sovilj D, Kelemen CD, Helman K, Jaksa R, Havranek O, Andera L, Trneny M, Klener P. Anti-apoptotic MCL1 Protein Represents Critical Survival Molecule for Most Burkitt Lymphomas and BCL2-negative Diffuse Large B-cell Lymphomas. Mol Cancer Ther. 2022 01; 21(1):89-99. PMID: 34728569; PMCID: PMC9398137.
      Citations:    Fields:    Translation:HumansCells
    13. Szydlowski M, Garbicz F, Jablonska E, Komar D, Pyrzynska B, Bojarczuk K, Prochorec-Sobieszek M, Szumera-Cieckiewicz A, Rymkiewicz G, Cybulska M, Statkiewicz M, Gajewska M, Mikula M, Golas A, Domagala J, Winiarska M, Graczyk-Jarzynka A, Bialopiotrowicz E, Polak A, Barankiewicz J, Pula B, Pawlak M, Nowis D, Golab J, Tomirotti AM, Pacheco-Blanco M, Kupcova K, Green MR, Havranek O, Juszczynski P, G?rniak P, Brz?zka K, Chapuy B. Inhibition of PIM Kinases in DLBCL Targets MYC Transcriptional Program and Augments the Efficacy of Anti-CD20 Antibodies. Cancer Res. 2021 12 01; 81(23):6029-6043. PMID: 34625423.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    14. Henderson J, Havranek O, Ma MCJ, Herman V, Kupcova K, Chrbolkova T, Pacheco-Blanco M, Wang Z, Comer JM, Zal T, Davis RE. Detecting F?rster resonance energy transfer in living cells by conventional and spectral flow cytometry. Cytometry A. 2022 10; 101(10):818-834. PMID: 34128311.
      Citations: 1     Fields:    
    15. Vockova P, Molinsky J, Klanova M, Karban J, Spacek M, Havranek O, Kupcova K, Kazantsev D, Trneny M, Klener P. CD31/PECAM-1 impacts engraftment, growth and spread of mantle cell lymphoma cells and positively correlates with extramedullary involvement. Leuk Lymphoma. 2021 04; 62(4):861-867. PMID: 33238780.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    16. Jain N, Singh S, Laliotis G, Hart A, Muhowski E, Kupcova K, Chrbolkova T, Khashab T, Chowdhury SM, Sircar A, Shirazi F, Singh RK, Alinari L, Zhu J, Havranek O, Tsichlis P, Woyach J, Baiocchi R, Samaniego F, Sehgal L. Targeting phosphatidylinositol 3 kinase-? and -d for Bruton tyrosine kinase resistance in diffuse large B-cell lymphoma. Blood Adv. 2020 09 22; 4(18):4382-4392. PMID: 32926124; PMCID: PMC7509871.
      Citations: 6     Fields:    Translation:HumansCells
    17. Jain N, Hartert K, Tadros S, Fiskus W, Havranek O, Ma MCJ, Bouska A, Heavican T, Kumar D, Deng Q, Moore D, Pak C, Liu CL, Gentles AJ, Kridel R, Smedby KE, Juliusson G, Rosenquist R, Gascoyne RD, Giancotti F, Neelapu SS, Westin J, Vose JM, Lunning MA, Greiner T, Rodig S, Iqbal J, Alizadeh AA, Davis RE, Bhalla K, Green MR, Hartmann E, Rosenwald A. Targetable genetic alterations of TCF4 (E2-2) drive immunoglobulin expression in diffuse large B cell lymphoma. Sci Transl Med. 2019 06 19; 11(497). PMID: 31217338; PMCID: PMC6724184.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    18. Kleiblova P, Stolarova L, Krizova K, Lhota F, Hojny J, Zemankova P, Havranek O, Vocka M, Cerna M, Lhotova K, Borecka M, Janatova M, Soukupova J, Sevcik J, Zimovjanova M, Kotlas J, Panczak A, Vesela K, Cervenkova J, Schneiderova M, Burocziova M, Burdova K, Stranecky V, Foretova L, Machackova E, Tavandzis S, Kmoch S, Macurek L, Kleibl Z. Identification of deleterious germline CHEK2 mutations and their association with breast and ovarian cancer. Int J Cancer. 2019 10 01; 145(7):1782-1797. PMID: 31050813.
      Citations: 22     Fields:    Translation:HumansCells
    19. Prukova D, Andera L, Nahacka Z, Karolova J, Svaton M, Klanova M, Havranek O, Soukup J, Svobodova K, Zemanova Z, Tuskova D, Pokorna E, Helman K, Forsterova K, Pacheco-Blanco M, Vockova P, Berkova A, Fronkova E, Trneny M, Klener P. Cotargeting of BCL2 with Venetoclax and MCL1 with S63845 Is Synthetically Lethal In Vivo in Relapsed Mantle Cell Lymphoma. Clin Cancer Res. 2019 07 15; 25(14):4455-4465. PMID: 31004002.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    20. Vangapandu HV, Havranek O, Ayres ML, Kaipparettu BA, Balakrishnan K, Wierda WG, Keating MJ, Davis RE, Stellrecht CM, Gandhi V. B-cell Receptor Signaling Regulates Metabolism in Chronic Lymphocytic Leukemia. Mol Cancer Res. 2017 12; 15(12):1692-1703. PMID: 28835371; PMCID: PMC5714317.
      Citations: 18     Fields:    Translation:HumansCells
    21. Havranek O, Xu J, Wang Z, Becker L, Comer JM, Henderson J, Ma W, Man Chun Ma J, Westin JR, Ghosh D, Shinners N, Sun L, Yi AF, Karri AR, Burger JA, Zal T, Davis RE, K?hrer S. Tonic B-cell receptor signaling in diffuse large B-cell lymphoma. Blood. 2017 08 24; 130(8):995-1006. PMID: 28646116; PMCID: PMC5813722.
      Citations: 30     Fields:    Translation:HumansCells
    22. Mathur R, Sehgal L, Havranek O, Khashab T, Jain N, Burger JA, Neelapu SS, Davis RE, Samaniego F, K?hrer S. Inhibition of demethylase KDM6B sensitizes diffuse large B-cell lymphoma to chemotherapeutic drugs. Haematologica. 2017 02; 102(2):373-380. PMID: 27742770; PMCID: PMC5286945.
      Citations: 28     Fields:    Translation:HumansCells
    23. Havranek O, Seyfried F, Hurtz C, Coffey GP, Kim E, Ten Hacken E, Vanura K, O'Brien S, Thomas DA, Kantarjian H, Ghosh D, Wang Z, Zhang M, Ma W, Jumaa H, Debatin KM, Meyer LH, Davis RE, Burger JA, K?hrer S, J?ger U, M?schen M. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia. 2016 06; 30(6):1246-54. PMID: 26847027; PMCID: PMC5459356.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    24. Havranek O, Kleiblova P, Hojny J, Lhota F, Soucek P, Trneny M, Kleibl Z. Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma. PLoS One. 2015; 10(10):e0140819. PMID: 26506619; PMCID: PMC4624763.
      Citations: 13     Fields:    Translation:HumansCells
    25. Cvek J, Feltl D, Hajek J, Jackaninova J, Ruzickova K, Havranek O, Dvorackova J, Dobes P. Is there an intermediate-risk non-seminoma? long-term treatment results from a single center. J BUON. 2014 Jul-Sep; 19(3):775-9. PMID: 25261666.
      Citations:    Fields:    Translation:Humans
    26. Havranek O, Spacek M, Hubacek P, Mocikova H, Benesova K, Soucek P, Trneny M, Kleibl Z. No association between the TP53 codon 72 polymorphism and risk or prognosis of Hodgkin and non-Hodgkin lymphoma. Leuk Res. 2011 Aug; 35(8):1117-9. PMID: 21546086.
      Citations: 3     Fields:    Translation:Humans
    27. Havranek O, Spacek M, Hubacek P, Mocikova H, Markova J, Trneny M, Kleibl Z. Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma. Neoplasma. 2011; 58(5):392-5. PMID: 21744992.
      Citations: 4     Fields:    Translation:HumansCells
    28. Mohelnikova-Duchonova B, Havranek O, Hlavata I, Foretova L, Kleibl Z, Pohlreich P, Soucek P. CHEK2 gene alterations in the forkhead-associated domain, 1100delC and del5395 do not modify the risk of sporadic pancreatic cancer. Cancer Epidemiol. 2010 Oct; 34(5):656-8. PMID: 20643596.
      Citations: 8     Fields:    Translation:HumansCells
    29. Kleibl Z, Havranek O, Kormunda S, Novotny J, Foretova L, Machackova E, Soukupova J, Janatova M, Tavandzis S, Pohlreich P. The AIB1 gene polyglutamine repeat length polymorphism and the risk of breast cancer development. J Cancer Res Clin Oncol. 2011 Feb; 137(2):331-8. PMID: 20422428.
      Citations: 4     Fields:    Translation:Humans
    30. Kleibl Z, Havranek O, Hlavata I, Novotny J, Sevcik J, Pohlreich P, Soucek P. The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. Eur J Cancer. 2009 Mar; 45(4):618-24. PMID: 18996005.
      Citations: 14     Fields:    Translation:Humans
    31. Kleibl Z, Havranek O, Novotny J, Kleiblova P, Soucek P, Pohlreich P. Analysis of CHEK2 FHA domain in Czech patients with sporadic breast cancer revealed distinct rare genetic alterations. Breast Cancer Res Treat. 2008 Nov; 112(1):159-64. PMID: 18058223.
      Citations: 8     Fields:    Translation:HumansCells
    32. Kleibl Z, Havranek O, Prokopcova J. Rapid detection of CAA/CAG repeat polymorphism in the AIB1 gene using DHPLC. J Biochem Biophys Methods. 2007 Apr 10; 70(3):511-3. PMID: 17234271.
      Citations: 2     Fields:    Translation:HumansCells
    33. Pre-BCR signaling in precursor B-cell acute lymphoblastic leukemia regulates PI3K/AKT, FOXO1 and MYC, and can be targeted by SYK inhibition. Leukemia.
    34. Analýza mutace c.1100delC genu CHEK2 v populaci pacientů se sporadickým karcinomem kolorekta a familiární adenomatózní polypózou. Klinicka Onkologie. 20:224-226.
    35. Association of germline CHEK2 gene variants with risk and prognosis of Non-Hodgkin Lymphoma. PLoS One. 10.
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