Loading...
Header Logo
Keywords
Last Name
Institution

AMATO J. GIACCIA

TitleVisiting Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    T32CA009302     (ATTARDI, LAURA D)Sep 15, 1977 - Aug 31, 2023
    NIH/NCI
    Cancer Etiology, Prevention, Detection and Diagnosis
    Role: Co-Principal Investigator

    R01CA003353     (GIACCIA, AMATO J.)Dec 1, 1978 - Nov 30, 1994
    NIH/NCI
    EXPERIMENTAL RADIOTHERAPY - CELLULAR RESPONSES IN VIVO
    Role: Principal Investigator

    R01CA058838     (GIACCIA, AMATO J.)Feb 1, 1993 - Jan 31, 1996
    NIH/NCI
    MOLECULAR CYTOGENETICS OF PROSTATE CANCER
    Role: Principal Investigator

    R01CA064489     (GIACCIA, AMATO J.)May 3, 1996 - May 31, 2000
    NIH/NCI
    REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Role: Principal Investigator

    P01CA067166     (GIACCIA, AMATO J.)Jun 15, 1996 - May 31, 2018
    NIH/NCI
    Tumor Hypoxia: Molecular Studies and Clinical Exploitation
    Role: Principal Investigator

    R01CA073832     (GIACCIA, AMATO J.)Dec 15, 1997 - Nov 30, 2000
    NIH/NCI
    MOLECULAR PHYSIOLOGY OF HYPOXIA INDUCED STRESS
    Role: Principal Investigator

    R01CA088480     (GIACCIA, AMATO J.)Jul 1, 2000 - Apr 30, 2010
    NIH/NCI
    Hypoxia and Gene Repression
    Role: Principal Investigator

    R37CA088480     (GIACCIA, AMATO J.)Jul 1, 2000 - Apr 30, 2015
    NIH/NCI
    Hypoxia and Gene Repression
    Role: Principal Investigator

    T32CA121940     (GIACCIA, AMATO J.)Jul 1, 2006 - Aug 31, 2019
    NIH/NCI
    Postdoctoral Training in the Radiation Scinces
    Role: Principal Investigator

    R01CA116685     (GIACCIA, AMATO J.)Sep 27, 2006 - Jul 31, 2012
    NIH/NCI
    CTGF in Pancreatic Tumor Growth
    Role: Principal Investigator

    R01AR065403     (SCHIPANI, ERNESTINA)Sep 26, 2013 - Aug 31, 2018
    NIH/NIAMS
    HIF-1alpha, a Survival and Differentiation Factor for Cartilage
    Role: Co-Principal Investigator

    R35CA197713     (GIACCIA, AMATO J.)Aug 1, 2015 - Jul 31, 2022
    NIH/NCI
    The Impact of Mitochondrial Repression and Lipid Accumulation by HIF on Tumor Growth
    Role: Principal Investigator

    R01CA198291     (RANKIN, ERINN B.)Apr 1, 2016 - Mar 31, 2021
    NIH/NCI
    Preclinical Testing of a Novel Therapy Targeting AXL in Advanced Kidney Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. VandeKopple MJ, Wu J, Auer EN, Giaccia AJ, Denko NC, Papandreou I. HILPDA regulates lipid metabolism, lipid droplet abundance and response to microenvironmental stress in solid tumors. Mol Cancer Res. 2019 Jul 15. PMID: 31308147.
      View in: PubMed
    2. Yao Q, Khan MP, Merceron C, LaGory EL, Tata Z, Mangiavini L, Hu J, Vemulapalli K, Chandel NS, Giaccia AJ, Schipani E. Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate. Dev Cell. 2019 Jun 03; 49(5):748-763.e7. PMID: 31105007.
      View in: PubMed
    3. Hu MS, Maan ZN, Leavitt T, Hong WX, Rennert RC, Marshall CD, Borrelli MR, Zhu TN, Esquivel M, Zimmermann A, McArdle A, Chung MT, Foster DS, Jones RE, Gurtner GC, Giaccia AJ, Lorenz HP, Weissman IL, Longaker MT. Wounds Inhibit Tumor Growth In Vivo. Ann Surg. 2019 Feb 27. PMID: 30829705.
      View in: PubMed
    4. Merceron C, Ranganathan K, Wang E, Tata Z, Makkapati S, Khan MP, Mangiavini L, Yao AQ, Castellini L, Levi B, Giaccia AJ, Schipani E. Hypoxia-inducible factor 2a is a negative regulator of osteoblastogenesis and bone mass accrual. Bone Res. 2019; 7:7. PMID: 30792937.
      View in: PubMed
    5. McGee HM, Jiang D, Soto-Pantoja DR, Nevler A, Giaccia AJ, Woodward WA. Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop. Clin Cancer Res. 2019 05 15; 25(10):2969-2974. PMID: 30723144.
      View in: PubMed
    6. Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon MC, Semenza GL, Nicolls MR. Endothelial Hypoxia-Inducible Factor-2a Is Required for the Maintenance of Airway Microvasculature. Circulation. 2019 Jan 22; 139(4):502-517. PMID: 30586708.
      View in: PubMed
    7. Olcina MM, Balanis NG, Kim RK, Aksoy BA, Kodysh J, Thompson MJ, Hammerbacher J, Graeber TG, Giaccia AJ. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018 Dec 26; 25(13):3721-3732.e6. PMID: 30590044.
      View in: PubMed
    8. Tandon N, Thakkar KN, LaGory EL, Liu Y, Giaccia AJ. Generation of Stable Expression Mammalian Cell Lines Using Lentivirus. Bio Protoc. 2018 Nov 05; 8(21). PMID: 30505888.
      View in: PubMed
    9. Chen X, Litzenburger UM, Wei Y, Schep AN, LaGory EL, Choudhry H, Giaccia AJ, Greenleaf WJ, Chang HY. Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nat Commun. 2018 11 02; 9(1):4590. PMID: 30389926.
      View in: PubMed
    10. Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10756-10761. PMID: 30201710.
      View in: PubMed
    11. Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst KC, Giaccia AJ, Graves EE. Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Res. 2018 Aug 01; 78(15):4241-4252. PMID: 29880480.
      View in: PubMed
    12. Olcina MM, Kim RK, Melemenidis S, Graves EE, Giaccia AJ. The tumour microenvironment links complement system dysregulation and hypoxic signalling?. Br J Radiol. 2018 May 15; 20180069. PMID: 29544344.
      View in: PubMed
    13. Shirato H, Le QT, Kobashi K, Prayongrat A, Takao S, Shimizu S, Giaccia A, Xing L, Umegaki K. Selection of external beam radiotherapy approaches for precise and accurate cancer treatment. J Radiat Res. 2018 Mar 01; 59(suppl_1):i2-i10. PMID: 29373709.
      View in: PubMed
    14. Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1a-XBP1 Activation. Mol Cancer Res. 2018 05; 16(5):745-753. PMID: 29440447.
      View in: PubMed
    15. Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plast Reconstr Surg. 2018 01; 141(1):55e-67e. PMID: 29280872.
      View in: PubMed
    16. LaGory EL, Giaccia AJ. Long-range hypoxia signaling in NAFLD. Nat Med. 2017 11 07; 23(11):1251-1252. PMID: 29117167.
      View in: PubMed
    17. Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM. BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer Discov. 2017 10; 7(10):1184-1199. PMID: 28790031.
      View in: PubMed
    18. Johnson RW, Sowder ME, Giaccia AJ. Hypoxia and Bone Metastatic Disease. Curr Osteoporos Rep. 2017 08; 15(4):231-238. PMID: 28597139.
      View in: PubMed
    19. VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I. Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol. 2017 Oct; 235(1):27-38. PMID: 28739822.
      View in: PubMed
    20. Giaccia A, Johnson RS. Lorenz Poellinger. Exp Cell Res. 2017 07 15; 356(2):115. PMID: 28622772.
      View in: PubMed
    21. Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells. Int J Nanomedicine. 2017; 12:5069-5085. PMID: 28860745.
      View in: PubMed
    22. Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017 04 20; 45(7):3674-3692. PMID: 28073943.
      View in: PubMed
    23. Vilalta M, Hughes NP, Von Eyben R, Giaccia AJ, Graves EE. Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location. Mol Imaging Biol. 2017 04; 19(2):215-224. PMID: 27709411.
      View in: PubMed
    24. Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017 05; 17(5):302-317. PMID: 28303905.
      View in: PubMed
    25. Aguilera TA, Giaccia AJ. Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase. Clin Cancer Res. 2017 Jun 15; 23(12):2928-2933. PMID: 28289089.
      View in: PubMed
    26. Weyandt JD, Thompson CB, Giaccia AJ, Rathmell WK. Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets. Am Soc Clin Oncol Educ Book. 2017; 37:825-832. PMID: 28561705.
      View in: PubMed
    27. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 12 23; 7:13898. PMID: 28008921.
      View in: PubMed
    28. Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017 01 03; 127(1):183-198. PMID: 27893463.
      View in: PubMed
    29. Rankin EB, Giaccia AJ. The Receptor Tyrosine Kinase AXL in Cancer Progression. Cancers (Basel). 2016 Nov 09; 8(11). PMID: 27834845.
      View in: PubMed
    30. Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13120-13125. PMID: 27799523.
      View in: PubMed
    31. Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016 10 27; 18(11):1260. PMID: 27784904.
      View in: PubMed
    32. Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016 10; 18(10):1078-1089. PMID: 27642788.
      View in: PubMed
    33. Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1a-XBP1 Axis of the Unfolded Protein Response. Sci Rep. 2016 09 16; 6:33353. PMID: 27634301.
      View in: PubMed
    34. Olcina MM, Giaccia AJ. Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis. J Clin Invest. 2016 10 03; 126(10):3708-3715. PMID: 27548524.
      View in: PubMed
    35. Giaccia AJ. A New Chromatin-Cytoskeleton Link in Cancer. Mol Cancer Res. 2016 12; 14(12):1173-1175. PMID: 27528705.
      View in: PubMed
    36. Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1a-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 09; 15(9):2055-65. PMID: 27307600.
      View in: PubMed
    37. Rankin EB, Nam JM, Giaccia AJ. Hypoxia: Signaling the Metastatic Cascade. Trends Cancer. 2016 06; 2(6):295-304. PMID: 28741527.
      View in: PubMed
    38. Rankin EB, Giaccia AJ. Hypoxic control of metastasis. Science. 2016 Apr 08; 352(6282):175-80. PMID: 27124451.
      View in: PubMed
    39. LaGory EL, Giaccia AJ. The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol. 2016 Apr; 18(4):356-65. PMID: 27027486.
      View in: PubMed
    40. Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Sci Rep. 2016 Feb 15; 6:21698. PMID: 26875667.
      View in: PubMed
    41. Sun RC, Koong A, Giaccia A, Denko NC. Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Adv Exp Med Biol. 2016; 899:113-20. PMID: 27325264.
      View in: PubMed
    42. Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Adv Exp Med Biol. 2016; 899:27-40. PMID: 27325260.
      View in: PubMed
    43. Ji J, Zöller B, Giaccia A, Haile R, Sundquist J, Sundquist K. Risk of breast cancer among patients with bioprosthetic or mechanical valve replacement: a population-based study in Sweden. Breast Cancer Res Treat. 2015 Nov; 154(2):369-75. PMID: 26476725.
      View in: PubMed
    44. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1a-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015 Nov; 185(11):3090-101. PMID: 26348575.
      View in: PubMed
    45. Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW, Shultz DB, Le QT, Koong AC, Chang DT. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015 Jul 01; 92(3):568-76. PMID: 26068491.
      View in: PubMed
    46. LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. Suppression of PGC-1a Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Rep. 2015 Jul 07; 12(1):116-127. PMID: 26119730.
      View in: PubMed
    47. Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Jun 01; 29(11):1202. PMID: 26063577.
      View in: PubMed
    48. Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation Oncology. Clin Cancer Res. 2015 Aug 01; 21(15):3393-401. PMID: 25991820.
      View in: PubMed
    49. Wu C, Rankin EB, Castellini L, Alcudia JF, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Apr 15; 29(8):817-31. PMID: 25846796.
      View in: PubMed
    50. Aguilera TA, Giaccia AJ. The end of the hypoxic EPOch. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):895-7. PMID: 25832683.
      View in: PubMed
    51. Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4441-6. PMID: 25792458.
      View in: PubMed
    52. Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Rep. 2015 Feb 24; 10(7):1096-109. PMID: 25704813.
      View in: PubMed
    53. Johnson RW, Schipani E, Giaccia AJ. HIF targets in bone remodeling and metastatic disease. Pharmacol Ther. 2015 Jun; 150:169-77. PMID: 25681658.
      View in: PubMed
    54. Wu C, Giaccia AJ, Rankin EB. Osteoblasts: a novel source of erythropoietin. Curr Osteoporos Rep. 2014 Dec; 12(4):428-32. PMID: 25204993.
      View in: PubMed
    55. Moon EJ, Giaccia A. Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment. Free Radic Biol Med. 2015 Feb; 79:292-9. PMID: 25458917.
      View in: PubMed
    56. Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1a in the notochord results in cell death and complete disappearance of the nucleus pulposus. PLoS One. 2014; 9(10):e110768. PMID: 25338007.
      View in: PubMed
    57. Kariolis MS, Miao YR, Jones DS, Kapur S, Mathews II, Giaccia AJ, Cochran JR. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Chem Biol. 2014 Nov; 10(11):977-83. PMID: 25242553.
      View in: PubMed
    58. Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia AJ, Koong AC, Diehn M, Le QT. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clin Cancer Res. 2014 Nov 01; 20(21):5558-69. PMID: 25189484.
      View in: PubMed
    59. Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13373-8. PMID: 25187556.
      View in: PubMed
    60. Giaccia AJ. Molecular radiobiology: the state of the art. J Clin Oncol. 2014 Sep 10; 32(26):2871-8. PMID: 25113768.
      View in: PubMed
    61. Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest. 2014 Aug; 124(8):3364-77. PMID: 25036711.
      View in: PubMed
    62. Vilalta M, Rafat M, Giaccia AJ, Graves EE. Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Rep. 2014 Jul 24; 8(2):402-9. PMID: 25017065.
      View in: PubMed
    63. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 01; 393(1):124-36. PMID: 24972088.
      View in: PubMed
    64. Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 2014 May 14; 6(236):236ra64. PMID: 24828078.
      View in: PubMed
    65. Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. PLoS One. 2014; 9(4):e93373. PMID: 24695462.
      View in: PubMed
    66. Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Adv Exp Med Biol. 2014; 772:v-viii. PMID: 24765667.
      View in: PubMed
    67. Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents. Bioorg Med Chem. 2014 Jan 15; 22(2):711-20. PMID: 24387866.
      View in: PubMed
    68. Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol. 2014 Feb; 34(4):739-51. PMID: 24344197.
      View in: PubMed
    69. Giaccia AJ. HIF-2: the missing link between obesity and cardiomyopathy. J Am Heart Assoc. 2013 Dec 16; 2(6):e000710. PMID: 24342999.
      View in: PubMed
    70. Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nat Med. 2013 Oct; 19(10):1325-30. PMID: 24037093.
      View in: PubMed
    71. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013 Oct; 19(10):1331-1337. PMID: 24037094.
      View in: PubMed
    72. Schipani E, Wu C, Rankin EB, Giaccia AJ. Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis. Front Endocrinol (Lausanne). 2013; 4:85. PMID: 23847596.
      View in: PubMed
    73. Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clin Cancer Res. 2013 Aug 15; 19(16):4455-64. PMID: 23812668.
      View in: PubMed
    74. LaGory EL, Giaccia AJ. A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth. Cell Cycle. 2013 Mar 01; 12(5):718-9. PMID: 23422857.
      View in: PubMed
    75. Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 2012 Oct; 3(10):1220-35. PMID: 23100451.
      View in: PubMed
    76. Wu C, Rankin EB, Giaccia AJ. Blood and bones: osteoblastic HIF signaling regulates erythropoiesis. Cell Cycle. 2012 Jun 15; 11(12):2221-2. PMID: 22627672.
      View in: PubMed
    77. Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, Rathmell WK. State of the science: an update on renal cell carcinoma. Mol Cancer Res. 2012 Jul; 10(7):859-80. PMID: 22638109.
      View in: PubMed
    78. Rankin EB, Wu C, Khatri R, Wilson TL, Andersen R, Araldi E, Rankin AL, Yuan J, Kuo CJ, Schipani E, Giaccia AJ. The HIF signaling pathway in osteoblasts directly modulates erythropoiesis through the production of EPO. Cell. 2012 Mar 30; 149(1):63-74. PMID: 22464323.
      View in: PubMed
    79. Le QT, Fisher R, Oliner KS, Young RJ, Cao H, Kong C, Graves E, Hicks RJ, McArthur GA, Peters L, O'Sullivan B, Giaccia A, Rischin D. Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clin Cancer Res. 2012 Mar 15; 18(6):1798-807. PMID: 22383739.
      View in: PubMed
    80. Maes C, Araldi E, Haigh K, Khatri R, Van Looveren R, Giaccia AJ, Haigh JJ, Carmeliet G, Schipani E. VEGF-independent cell-autonomous functions of HIF-1a regulating oxygen consumption in fetal cartilage are critical for chondrocyte survival. J Bone Miner Res. 2012 Mar; 27(3):596-609. PMID: 22162090.
      View in: PubMed
    81. Lim AM, Rischin D, Fisher R, Cao H, Kwok K, Truong D, McArthur GA, Young RJ, Giaccia A, Peters L, Le QT. Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial. Clin Cancer Res. 2012 Jan 01; 18(1):301-7. PMID: 22096023.
      View in: PubMed
    82. Huang M, Nguyen P, Jia F, Hu S, Gong Y, de Almeida PE, Wang L, Nag D, Kay MA, Giaccia AJ, Robbins RC, Wu JC. Double knockdown of prolyl hydroxylase and factor-inhibiting hypoxia-inducible factor with nonviral minicircle gene therapy enhances stem cell mobilization and angiogenesis after myocardial infarction. Circulation. 2011 Sep 13; 124(11 Suppl):S46-54. PMID: 21911818.
      View in: PubMed
    83. Chan DA, Sutphin PD, Nguyen P, Turcotte S, Lai EW, Banh A, Reynolds GE, Chi JT, Wu J, Solow-Cordero DE, Bonnet M, Flanagan JU, Bouley DM, Graves EE, Denny WA, Hay MP, Giaccia AJ. Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. Sci Transl Med. 2011 Aug 03; 3(94):94ra70. PMID: 21813754.
      View in: PubMed
    84. Rankin EB, Giaccia AJ, Schipani E. A central role for hypoxic signaling in cartilage, bone, and hematopoiesis. Curr Osteoporos Rep. 2011 Jun; 9(2):46-52. PMID: 21360287.
      View in: PubMed
    85. Banh A, Zhang J, Cao H, Bouley DM, Kwok S, Kong C, Giaccia AJ, Koong AC, Le QT. Tumor galectin-1 mediates tumor growth and metastasis through regulation of T-cell apoptosis. Cancer Res. 2011 Jul 01; 71(13):4423-31. PMID: 21546572.
      View in: PubMed
    86. Chan DA, Giaccia AJ. Harnessing synthetic lethal interactions in anticancer drug discovery. Nat Rev Drug Discov. 2011 May; 10(5):351-64. PMID: 21532565.
      View in: PubMed
    87. Bonnet M, Flanagan JU, Chan DA, Lai EW, Nguyen P, Giaccia AJ, Hay MP. SAR studies of 4-pyridyl heterocyclic anilines that selectively induce autophagic cell death in von Hippel-Lindau-deficient renal cell carcinoma cells. Bioorg Med Chem. 2011 Jun 01; 19(11):3347-56. PMID: 21561782.
      View in: PubMed
    88. Welford SM, Giaccia AJ. Hypoxia and senescence: the impact of oxygenation on tumor suppression. Mol Cancer Res. 2011 May; 9(5):538-44. PMID: 21385881.
      View in: PubMed
    89. Razorenova OV, Finger EC, Colavitti R, Chernikova SB, Boiko AD, Chan CK, Krieg A, Bedogni B, LaGory E, Weissman IL, Broome-Powell M, Giaccia AJ. VHL loss in renal cell carcinoma leads to up-regulation of CUB domain-containing protein 1 to stimulate PKC{delta}-driven migration. Proc Natl Acad Sci U S A. 2011 Feb 01; 108(5):1931-6. PMID: 21233420.
      View in: PubMed
    90. Araldi E, Khatri R, Giaccia AJ, Simon MC, Schipani E. Lack of HIF-2a in limb bud mesenchyme causes a modest and transient delay of endochondral bone development. Nat Med. 2011 Jan; 17(1):25-6; author reply 27-9. PMID: 21217667.
      View in: PubMed
    91. Pestov NB, Okkelman IA, Shmanai VV, Hurski AL, Giaccia AJ, Shchepinov MS. Control of lysyl oxidase activity through site-specific deuteration of lysine. Bioorg Med Chem Lett. 2011 Jan 01; 21(1):255-8. PMID: 21106372.
      View in: PubMed
    92. Rankin EB, Fuh KC, Taylor TE, Krieg AJ, Musser M, Yuan J, Wei K, Kuo CJ, Longacre TA, Giaccia AJ. AXL is an essential factor and therapeutic target for metastatic ovarian cancer. Cancer Res. 2010 Oct 01; 70(19):7570-9. PMID: 20858715.
      View in: PubMed
    93. Graves EE, Vilalta M, Cecic IK, Erler JT, Tran PT, Felsher D, Sayles L, Sweet-Cordero A, Le QT, Giaccia AJ. Hypoxia in models of lung cancer: implications for targeted therapeutics. Clin Cancer Res. 2010 Oct 01; 16(19):4843-52. PMID: 20858837.
      View in: PubMed
    94. Welford SM, Dorie MJ, Li X, Haase VH, Giaccia AJ. Renal oxygenation suppresses VHL loss-induced senescence that is caused by increased sensitivity to oxidative stress. Mol Cell Biol. 2010 Oct; 30(19):4595-603. PMID: 20679489.
      View in: PubMed
    95. Patten DA, Lafleur VN, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. Hypoxia-inducible factor-1 activation in nonhypoxic conditions: the essential role of mitochondrial-derived reactive oxygen species. Mol Biol Cell. 2010 Sep 15; 21(18):3247-57. PMID: 20660157.
      View in: PubMed
    96. Wiley M, Sweeney KR, Chan DA, Brown KM, McMurtrey C, Howard EW, Giaccia AJ, Blader IJ. Toxoplasma gondii activates hypoxia-inducible factor (HIF) by stabilizing the HIF-1alpha subunit via type I activin-like receptor kinase receptor signaling. J Biol Chem. 2010 Aug 27; 285(35):26852-60. PMID: 20581113.
      View in: PubMed
    97. Finger EC, Giaccia AJ. Hypoxia, inflammation, and the tumor microenvironment in metastatic disease. Cancer Metastasis Rev. 2010 Jun; 29(2):285-93. PMID: 20393783.
      View in: PubMed
    98. Huang X, Le QT, Giaccia AJ. MiR-210--micromanager of the hypoxia pathway. Trends Mol Med. 2010 May; 16(5):230-7. PMID: 20434954.
      View in: PubMed
    99. Courter D, Cao H, Kwok S, Kong C, Banh A, Kuo P, Bouley DM, Vice C, Brustugun OT, Denko NC, Koong AC, Giaccia A, Le QT. The RGD domain of human osteopontin promotes tumor growth and metastasis through activation of survival pathways. PLoS One. 2010 Mar 10; 5(3):e9633. PMID: 20224789.
      View in: PubMed
    100. Hay MP, Turcotte S, Flanagan JU, Bonnet M, Chan DA, Sutphin PD, Nguyen P, Giaccia AJ, Denny WA. 4-Pyridylanilinothiazoles that selectively target von Hippel-Lindau deficient renal cell carcinoma cells by inducing autophagic cell death. J Med Chem. 2010 Jan 28; 53(2):787-97. PMID: 19994864.
      View in: PubMed
    101. Turcotte S, Giaccia AJ. Targeting cancer cells through autophagy for anticancer therapy. Curr Opin Cell Biol. 2010 Apr; 22(2):246-51. PMID: 20056398.
      View in: PubMed
    102. Krieg AJ, Rankin EB, Chan D, Razorenova O, Fernandez S, Giaccia AJ. Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth. Mol Cell Biol. 2010 Jan; 30(1):344-53. PMID: 19858293.
      View in: PubMed
    103. Giaccia AJ, Schipani E. Role of carcinoma-associated fibroblasts and hypoxia in tumor progression. Curr Top Microbiol Immunol. 2010; 345:31-45. PMID: 20517716.
      View in: PubMed
    104. Xu Y, Hammerick KE, James AW, Carre AL, Leucht P, Giaccia AJ, Longaker MT. Inhibition of histone deacetylase activity in reduced oxygen environment enhances the osteogenesis of mouse adipose-derived stromal cells. Tissue Eng Part A. 2009 Dec; 15(12):3697-707. PMID: 19505250.
      View in: PubMed
    105. Levental KR, Yu H, Kass L, Lakins JN, Egeblad M, Erler JT, Fong SF, Csiszar K, Giaccia A, Weninger W, Yamauchi M, Gasser DL, Weaver VM. Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell. 2009 Nov 25; 139(5):891-906. PMID: 19931152.
      View in: PubMed
    106. Cairns RA, Bennewith KL, Graves EE, Giaccia AJ, Chang DT, Denko NC. Pharmacologically increased tumor hypoxia can be measured by 18F-Fluoroazomycin arabinoside positron emission tomography and enhances tumor response to hypoxic cytotoxin PR-104. Clin Cancer Res. 2009 Dec 01; 15(23):7170-4. PMID: 19920111.
      View in: PubMed
    107. Granchi C, Funaioli T, Erler JT, Giaccia AJ, Macchia M, Minutolo F. Bioreductively activated lysyl oxidase inhibitors against hypoxic tumours. ChemMedChem. 2009 Oct; 4(10):1590-4. PMID: 19685543.
      View in: PubMed
    108. Huang X, Ding L, Bennewith KL, Tong RT, Welford SM, Ang KK, Story M, Le QT, Giaccia AJ. Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation. Mol Cell. 2009 Sep 24; 35(6):856-67. PMID: 19782034.
      View in: PubMed
    109. Le QT, Harris J, Magliocco AM, Kong CS, Diaz R, Shin B, Cao H, Trotti A, Erler JT, Chung CH, Dicker A, Pajak TF, Giaccia AJ, Ang KK. Validation of lysyl oxidase as a prognostic marker for metastasis and survival in head and neck squamous cell carcinoma: Radiation Therapy Oncology Group trial 90-03. J Clin Oncol. 2009 Sep 10; 27(26):4281-6. PMID: 19667273.
      View in: PubMed
    110. Rankin EB, Giaccia AJ, Hammond EM. Bringing H2AX into the angiogenesis family. Cancer Cell. 2009 Jun 02; 15(6):459-61. PMID: 19477424.
      View in: PubMed
    111. Chan DA, Kawahara TL, Sutphin PD, Chang HY, Chi JT, Giaccia AJ. Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment. Cancer Cell. 2009 Jun 02; 15(6):527-38. PMID: 19477431.
      View in: PubMed
    112. Ghosh AK, Shanafelt TD, Cimmino A, Taccioli C, Volinia S, Liu CG, Calin GA, Croce CM, Chan DA, Giaccia AJ, Secreto C, Wellik LE, Lee YK, Mukhopadhyay D, Kay NE. Aberrant regulation of pVHL levels by microRNA promotes the HIF/VEGF axis in CLL B cells. Blood. 2009 May 28; 113(22):5568-74. PMID: 19336759.
      View in: PubMed
    113. Bennewith KL, Huang X, Ham CM, Graves EE, Erler JT, Kambham N, Feazell J, Yang GP, Koong A, Giaccia AJ. The role of tumor cell-derived connective tissue growth factor (CTGF/CCN2) in pancreatic tumor growth. Cancer Res. 2009 Feb 01; 69(3):775-84. PMID: 19179545.
      View in: PubMed
    114. Erler JT, Bennewith KL, Cox TR, Lang G, Bird D, Koong A, Le QT, Giaccia AJ. Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche. Cancer Cell. 2009 Jan 06; 15(1):35-44. PMID: 19111879.
      View in: PubMed
    115. Torti FM, Altieri D, Broach J, Fan H, Lotze M, Manfredi J, Matrisian L, Yu D, Giaccia A. Ph.D. Training in cancer biology. Cancer Res. 2008 Nov 15; 68(22):9122-4. PMID: 19010881.
      View in: PubMed
    116. Bencokova Z, Kaufmann MR, Pires IM, Lecane PS, Giaccia AJ, Hammond EM. ATM activation and signaling under hypoxic conditions. Mol Cell Biol. 2009 Jan; 29(2):526-37. PMID: 18981219.
      View in: PubMed
    117. Bedogni B, Warneke JA, Nickoloff BJ, Giaccia AJ, Powell MB. Notch1 is an effector of Akt and hypoxia in melanoma development. J Clin Invest. 2008 Nov; 118(11):3660-70. PMID: 18924608.
      View in: PubMed
    118. Turcotte S, Sutphin PD, Giaccia AJ. Targeted therapy for the loss of von Hippel-Lindau in renal cell carcinoma: a novel molecule that induces autophagic cell death. Autophagy. 2008 Oct; 4(7):944-6. PMID: 18769110.
      View in: PubMed
    119. Chan DA, Giaccia AJ. Targeting cancer cells by synthetic lethality: autophagy and VHL in cancer therapeutics. Cell Cycle. 2008 Oct; 7(19):2987-90. PMID: 18818511.
      View in: PubMed
    120. Huang M, Chan DA, Jia F, Xie X, Li Z, Hoyt G, Robbins RC, Chen X, Giaccia AJ, Wu JC. Short hairpin RNA interference therapy for ischemic heart disease. Circulation. 2008 Sep 30; 118(14 Suppl):S226-33. PMID: 18824759.
      View in: PubMed
    121. Turcotte S, Chan DA, Sutphin PD, Hay MP, Denny WA, Giaccia AJ. A molecule targeting VHL-deficient renal cell carcinoma that induces autophagy. Cancer Cell. 2008 Jul 08; 14(1):90-102. PMID: 18598947.
      View in: PubMed
    122. Basak S, Jacobs SB, Krieg AJ, Pathak N, Zeng Q, Kaldis P, Giaccia AJ, Attardi LD. The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell. 2008 May 09; 30(3):303-14. PMID: 18471976.
      View in: PubMed
    123. Choi CY, Chan DA, Paulmurugan R, Sutphin PD, Le QT, Koong AC, Zundel W, Gambhir SS, Giaccia AJ. Molecular imaging of hypoxia-inducible factor 1 alpha and von Hippel-Lindau interaction in mice. Mol Imaging. 2008 May-Jun; 7(3):139-46. PMID: 19123984.
      View in: PubMed
    124. Lauzier MC, Robitaille GA, Chan DA, Giaccia AJ, Richard DE. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Mol Pharmacol. 2008 Jul; 74(1):282-8. PMID: 18424552.
      View in: PubMed
    125. Xu Y, Malladi P, Chiou M, Bekerman E, Giaccia AJ, Longaker MT. In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis. Tissue Eng. 2007 Dec; 13(12):2981-93. PMID: 17916040.
      View in: PubMed
    126. Hammond EM, Kaufmann MR, Giaccia AJ. Oxygen sensing and the DNA-damage response. Curr Opin Cell Biol. 2007 Dec; 19(6):680-4. PMID: 18023567.
      View in: PubMed
    127. Chang EI, Loh SA, Ceradini DJ, Chang EI, Lin SE, Bastidas N, Aarabi S, Chan DA, Freedman ML, Giaccia AJ, Gurtner GC. Age decreases endothelial progenitor cell recruitment through decreases in hypoxia-inducible factor 1alpha stabilization during ischemia. Circulation. 2007 Dec 11; 116(24):2818-29. PMID: 18040029.
      View in: PubMed
    128. Pagé EL, Chan DA, Giaccia AJ, Levine M, Richard DE. Hypoxia-inducible factor-1alpha stabilization in nonhypoxic conditions: role of oxidation and intracellular ascorbate depletion. Mol Biol Cell. 2008 Jan; 19(1):86-94. PMID: 17942596.
      View in: PubMed
    129. Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC. Expression and prognostic significance of a panel of tissue hypoxia markers in head-and-neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys. 2007 Sep 01; 69(1):167-75. PMID: 17707270.
      View in: PubMed
    130. Cecic I, Chan DA, Sutphin PD, Ray P, Gambhir SS, Giaccia AJ, Graves EE. Oxygen sensitivity of reporter genes: implications for preclinical imaging of tumor hypoxia. Mol Imaging. 2007 Jul-Aug; 6(4):219-28. PMID: 17711777.
      View in: PubMed
    131. Sutphin PD, Chan DA, Li JM, Turcotte S, Krieg AJ, Giaccia AJ. Targeting the loss of the von Hippel-Lindau tumor suppressor gene in renal cell carcinoma cells. Cancer Res. 2007 Jun 15; 67(12):5896-905. PMID: 17575159.
      View in: PubMed
    132. Sutphin PD, Giaccia AJ, Chan DA. Energy regulation: HIF MXIes it up with the C-MYC powerhouse. Dev Cell. 2007 Jun; 12(6):845-6. PMID: 17543856.
      View in: PubMed
    133. Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Hypoxia inducible factor-1alpha deficiency affects chondrogenesis of adipose-derived adult stromal cells. Tissue Eng. 2007 Jun; 13(6):1159-71. PMID: 17518738.
      View in: PubMed
    134. Chan DA, Giaccia AJ. Hypoxia, gene expression, and metastasis. Cancer Metastasis Rev. 2007 Jun; 26(2):333-9. PMID: 17458506.
      View in: PubMed
    135. Provot S, Zinyk D, Gunes Y, Kathri R, Le Q, Kronenberg HM, Johnson RS, Longaker MT, Giaccia AJ, Schipani E. Hif-1alpha regulates differentiation of limb bud mesenchyme and joint development. J Cell Biol. 2007 May 07; 177(3):451-64. PMID: 17470636.
      View in: PubMed
    136. Graves EE, Giaccia AJ. Imaging tumoral hypoxia: oxygen concentrations and beyond. Oncology (Williston Park). 2007 Mar; 21(3):368-76; discussion 377-8, 384. PMID: 17447439.
      View in: PubMed
    137. Chan DA, Krieg AJ, Turcotte S, Giaccia AJ. HIF gene expression in cancer therapy. Methods Enzymol. 2007; 435:323-45. PMID: 17998061.
      View in: PubMed
    138. Welford SM, Bedogni B, Gradin K, Poellinger L, Broome Powell M, Giaccia AJ. HIF1alpha delays premature senescence through the activation of MIF. Genes Dev. 2006 Dec 15; 20(24):3366-71. PMID: 17142669.
      View in: PubMed
    139. Petrik D, Lavori PW, Cao H, Zhu Y, Wong P, Christofferson E, Kaplan MJ, Pinto HA, Sutphin P, Koong AC, Giaccia AJ, Le QT. Plasma osteopontin is an independent prognostic marker for head and neck cancers. J Clin Oncol. 2006 Nov 20; 24(33):5291-7. PMID: 17114663.
      View in: PubMed
    140. Pan Y, Mansfield KD, Bertozzi CC, Rudenko V, Chan DA, Giaccia AJ, Simon MC. Multiple factors affecting cellular redox status and energy metabolism modulate hypoxia-inducible factor prolyl hydroxylase activity in vivo and in vitro. Mol Cell Biol. 2007 Feb; 27(3):912-25. PMID: 17101781.
      View in: PubMed
    141. Erler JT, Giaccia AJ. Lysyl oxidase mediates hypoxic control of metastasis. Cancer Res. 2006 Nov 01; 66(21):10238-41. PMID: 17079439.
      View in: PubMed
    142. Tatum JL, Kelloff GJ, Gillies RJ, Arbeit JM, Brown JM, Chao KS, Chapman JD, Eckelman WC, Fyles AW, Giaccia AJ, Hill RP, Koch CJ, Krishna MC, Krohn KA, Lewis JS, Mason RP, Melillo G, Padhani AR, Powis G, Rajendran JG, Reba R, Robinson SP, Semenza GL, Swartz HM, Vaupel P, Yang D, Croft B, Hoffman J, Liu G, Stone H, Sullivan D. Hypoxia: importance in tumor biology, noninvasive measurement by imaging, and value of its measurement in the management of cancer therapy. Int J Radiat Biol. 2006 Oct; 82(10):699-757. PMID: 17118889.
      View in: PubMed
    143. Krieg AJ, Hammond EM, Giaccia AJ. Functional analysis of p53 binding under differential stresses. Mol Cell Biol. 2006 Oct; 26(19):7030-45. PMID: 16980608.
      View in: PubMed
    144. Hammond EM, Giaccia AJ. Hypoxia-inducible factor-1 and p53: friends, acquaintances, or strangers? Clin Cancer Res. 2006 Sep 01; 12(17):5007-9. PMID: 16951213.
      View in: PubMed
    145. Freiberg RA, Krieg AJ, Giaccia AJ, Hammond EM. Checking in on hypoxia/reoxygenation. Cell Cycle. 2006 Jun; 5(12):1304-7. PMID: 16760660.
      View in: PubMed
    146. Dornhöfer N, Spong S, Bennewith K, Salim A, Klaus S, Kambham N, Wong C, Kaper F, Sutphin P, Nacamuli R, Nacalumi R, Höckel M, Le Q, Longaker M, Yang G, Koong A, Giaccia A. Connective tissue growth factor-specific monoclonal antibody therapy inhibits pancreatic tumor growth and metastasis. Cancer Res. 2006 Jun 01; 66(11):5816-27. PMID: 16740721.
      View in: PubMed
    147. Hammond EM, Mandell DJ, Salim A, Krieg AJ, Johnson TM, Shirazi HA, Attardi LD, Giaccia AJ. Genome-wide analysis of p53 under hypoxic conditions. Mol Cell Biol. 2006 May; 26(9):3492-504. PMID: 16611991.
      View in: PubMed
    148. Erler JT, Bennewith KL, Nicolau M, Dornhöfer N, Kong C, Le QT, Chi JT, Jeffrey SS, Giaccia AJ. Lysyl oxidase is essential for hypoxia-induced metastasis. Nature. 2006 Apr 27; 440(7088):1222-6. PMID: 16642001.
      View in: PubMed
    149. Freiberg RA, Hammond EM, Dorie MJ, Welford SM, Giaccia AJ. DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. Mol Cell Biol. 2006 Mar; 26(5):1598-609. PMID: 16478982.
      View in: PubMed
    150. Le QT, Chen E, Salim A, Cao H, Kong CS, Whyte R, Donington J, Cannon W, Wakelee H, Tibshirani R, Mitchell JD, Richardson D, O'Byrne KJ, Koong AC, Giaccia AJ. An evaluation of tumor oxygenation and gene expression in patients with early stage non-small cell lung cancers. Clin Cancer Res. 2006 Mar 01; 12(5):1507-14. PMID: 16533775.
      View in: PubMed
    151. Chi JT, Wang Z, Nuyten DS, Rodriguez EH, Schaner ME, Salim A, Wang Y, Kristensen GB, Helland A, Børresen-Dale AL, Giaccia A, Longaker MT, Hastie T, Yang GP, van de Vijver MJ, Brown PO. Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers. PLoS Med. 2006 Mar; 3(3):e47. PMID: 16417408.
      View in: PubMed
    152. Spear W, Chan D, Coppens I, Johnson RS, Giaccia A, Blader IJ. The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels. Cell Microbiol. 2006 Feb; 8(2):339-52. PMID: 16441443.
      View in: PubMed
    153. Kaper F, Dornhoefer N, Giaccia AJ. Mutations in the PI3K/PTEN/TSC2 pathway contribute to mammalian target of rapamycin activity and increased translation under hypoxic conditions. Cancer Res. 2006 Feb 01; 66(3):1561-9. PMID: 16452213.
      View in: PubMed
    154. Le QT, Cao H, Koong A, Giaccia A. Comment on: osteopontin as toxic marker. Radiother Oncol. 2006 Feb; 78(2):230; author reply 230-1. PMID: 16442647.
      View in: PubMed
    155. Bedogni B, Welford SM, Cassarino DS, Nickoloff BJ, Giaccia AJ, Powell MB. The hypoxic microenvironment of the skin contributes to Akt-mediated melanocyte transformation. Cancer Cell. 2005 Dec; 8(6):443-54. PMID: 16338658.
      View in: PubMed
    156. Malladi P, Xu Y, Chiou M, Giaccia AJ, Longaker MT. Effect of reduced oxygen tension on chondrogenesis and osteogenesis in adipose-derived mesenchymal cells. Am J Physiol Cell Physiol. 2006 Apr; 290(4):C1139-46. PMID: 16291817.
      View in: PubMed
    157. Le QT, Shi G, Cao H, Nelson DW, Wang Y, Chen EY, Zhao S, Kong C, Richardson D, O'Byrne KJ, Giaccia AJ, Koong AC. Galectin-1: a link between tumor hypoxia and tumor immune privilege. J Clin Oncol. 2005 Dec 10; 23(35):8932-41. PMID: 16219933.
      View in: PubMed
    158. Zhu Y, Denhardt DT, Cao H, Sutphin PD, Koong AC, Giaccia AJ, Le QT. Hypoxia upregulates osteopontin expression in NIH-3T3 cells via a Ras-activated enhancer. Oncogene. 2005 Sep 29; 24(43):6555-63. PMID: 16007184.
      View in: PubMed
    159. Hammond EM, Freiberg RA, Giaccia AJ. The roles of Chk 1 and Chk 2 in hypoxia and reoxygenation. Cancer Lett. 2006 Jul 18; 238(2):161-7. PMID: 16085356.
      View in: PubMed
    160. Chan DA, Sutphin PD, Yen SE, Giaccia AJ. Coordinate regulation of the oxygen-dependent degradation domains of hypoxia-inducible factor 1 alpha. Mol Cell Biol. 2005 Aug; 25(15):6415-26. PMID: 16024780.
      View in: PubMed
    161. Nelson DW, Cao H, Zhu Y, Sunar-Reeder B, Choi CY, Faix JD, Brown JM, Koong AC, Giaccia AJ, Le QT. A noninvasive approach for assessing tumor hypoxia in xenografts: developing a urinary marker for hypoxia. Cancer Res. 2005 Jul 15; 65(14):6151-8. PMID: 16024616.
      View in: PubMed
    162. Hammond EM, Giaccia AJ. The role of p53 in hypoxia-induced apoptosis. Biochem Biophys Res Commun. 2005 Jun 10; 331(3):718-25. PMID: 15865928.
      View in: PubMed
    163. Papandreou I, Krishna C, Kaper F, Cai D, Giaccia AJ, Denko NC. Anoxia is necessary for tumor cell toxicity caused by a low-oxygen environment. Cancer Res. 2005 Apr 15; 65(8):3171-8. PMID: 15833847.
      View in: PubMed
    164. Yun Z, Lin Q, Giaccia AJ. Adaptive myogenesis under hypoxia. Mol Cell Biol. 2005 Apr; 25(8):3040-55. PMID: 15798192.
      View in: PubMed
    165. Fang TD, Salim A, Xia W, Nacamuli RP, Guccione S, Song HM, Carano RA, Filvaroff EH, Bednarski MD, Giaccia AJ, Longaker MT. Angiogenesis is required for successful bone induction during distraction osteogenesis. J Bone Miner Res. 2005 Jul; 20(7):1114-24. PMID: 15940364.
      View in: PubMed
    166. Baek JH, Mahon PC, Oh J, Kelly B, Krishnamachary B, Pearson M, Chan DA, Giaccia AJ, Semenza GL. OS-9 interacts with hypoxia-inducible factor 1alpha and prolyl hydroxylases to promote oxygen-dependent degradation of HIF-1alpha. Mol Cell. 2005 Feb 18; 17(4):503-12. PMID: 15721254.
      View in: PubMed
    167. Johnson TM, Hammond EM, Giaccia A, Attardi LD. The p53QS transactivation-deficient mutant shows stress-specific apoptotic activity and induces embryonic lethality. Nat Genet. 2005 Feb; 37(2):145-52. PMID: 15654339.
      View in: PubMed
    168. Chen Y, Shi G, Xia W, Kong C, Zhao S, Gaw AF, Chen EY, Yang GP, Giaccia AJ, Le QT, Koong AC. Identification of hypoxia-regulated proteins in head and neck cancer by proteomic and tissue array profiling. Cancer Res. 2004 Oct 15; 64(20):7302-10. PMID: 15492250.
      View in: PubMed
    169. Gerald D, Berra E, Frapart YM, Chan DA, Giaccia AJ, Mansuy D, Pouysségur J, Yaniv M, Mechta-Grigoriou F. JunD reduces tumor angiogenesis by protecting cells from oxidative stress. Cell. 2004 Sep 17; 118(6):781-94. PMID: 15369676.
      View in: PubMed
    170. Giaccia AJ, Simon MC, Johnson R. The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease. Genes Dev. 2004 Sep 15; 18(18):2183-94. PMID: 15371333.
      View in: PubMed
    171. Hammond EM, Dorie MJ, Giaccia AJ. Inhibition of ATR leads to increased sensitivity to hypoxia/reoxygenation. Cancer Res. 2004 Sep 15; 64(18):6556-62. PMID: 15374968.
      View in: PubMed
    172. Bernier J, Hall EJ, Giaccia A. Radiation oncology: a century of achievements. Nat Rev Cancer. 2004 09; 4(9):737-47. PMID: 15343280.
      View in: PubMed
    173. Huang ST, Vo KC, Lyell DJ, Faessen GH, Tulac S, Tibshirani R, Giaccia AJ, Giudice LC. Developmental response to hypoxia. FASEB J. 2004 Sep; 18(12):1348-65. PMID: 15333578.
      View in: PubMed
    174. Romero-Ramirez L, Cao H, Nelson D, Hammond E, Lee AH, Yoshida H, Mori K, Glimcher LH, Denko NC, Giaccia AJ, Le QT, Koong AC. XBP1 is essential for survival under hypoxic conditions and is required for tumor growth. Cancer Res. 2004 Sep 01; 64(17):5943-7. PMID: 15342372.
      View in: PubMed
    175. Hammond EM, Giaccia AJ. The role of ATM and ATR in the cellular response to hypoxia and re-oxygenation. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):1117-22. PMID: 15279800.
      View in: PubMed
    176. Le QT, Denko NC, Giaccia AJ. Hypoxic gene expression and metastasis. Cancer Metastasis Rev. 2004 Aug-Dec; 23(3-4):293-310. PMID: 15197330.
      View in: PubMed
    177. Salim A, Nacamuli RP, Morgan EF, Giaccia AJ, Longaker MT. Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts. J Biol Chem. 2004 Sep 17; 279(38):40007-16. PMID: 15263007.
      View in: PubMed
    178. Salim A, Giaccia AJ, Longaker MT. Stem cell differentiation. Nat Biotechnol. 2004 Jul; 22(7):804-5; author reply 805-6. PMID: 15229534.
      View in: PubMed
    179. Leo C, Giaccia AJ, Denko NC. The hypoxic tumor microenvironment and gene expression. Semin Radiat Oncol. 2004 Jul; 14(3):207-14. PMID: 15254863.
      View in: PubMed
    180. Kaufman B, Scharf O, Arbeit J, Ashcroft M, Brown JM, Bruick RK, Chapman JD, Evans SM, Giaccia AJ, Harris AL, Huang E, Johnson R, Kaelin W, Koch CJ, Maxwell P, Mitchell J, Neckers L, Powis G, Rajendran J, Semenza GL, Simons J, Storkebaum E, Welch MJ, Whitelaw M, Melillo G, Ivy SP. Proceedings of the Oxygen Homeostasis/Hypoxia Meeting. Cancer Res. 2004 May 01; 64(9):3350-6. PMID: 15126380.
      View in: PubMed
    181. Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10):2497-508. PMID: 15128677.
      View in: PubMed
    182. Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004 Apr 01; 18(7):739-44. PMID: 15082527.
      View in: PubMed
    183. Bedogni B, O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB. Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Cancer Res. 2004 Apr 01; 64(7):2552-60. PMID: 15059911.
      View in: PubMed
    184. Sutphin PD, Chan DA, Giaccia AJ. Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle. 2004 Feb; 3(2):160-3. PMID: 14712081.
      View in: PubMed
    185. Swiersz LM, Giaccia AJ, Yun Z. Oxygen-dependent regulation of adipogenesis. Methods Enzymol. 2004; 381:387-95. PMID: 15063688.
      View in: PubMed
    186. Hammond EM, Green SL, Giaccia AJ. Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest. Mutat Res. 2003 Nov 27; 532(1-2):205-13. PMID: 14643437.
      View in: PubMed
    187. Giaccia A, Siim BG, Johnson RS. HIF-1 as a target for drug development. Nat Rev Drug Discov. 2003 Oct; 2(10):803-11. PMID: 14526383.
      View in: PubMed
    188. Le QT, Giaccia AJ. Therapeutic exploitation of the physiological and molecular genetic alterations in head and neck cancer. Clin Cancer Res. 2003 Oct 01; 9(12):4287-95. PMID: 14555497.
      View in: PubMed
    189. Denko NC, Fontana LA, Hudson KM, Sutphin PD, Raychaudhuri S, Altman R, Giaccia AJ. Investigating hypoxic tumor physiology through gene expression patterns. Oncogene. 2003 Sep 01; 22(37):5907-14. PMID: 12947397.
      View in: PubMed
    190. Park SK, Dadak AM, Haase VH, Fontana L, Giaccia AJ, Johnson RS. Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1alpha (HIF-1alpha): role of cytoplasmic trapping of HIF-2alpha. Mol Cell Biol. 2003 Jul; 23(14):4959-71. PMID: 12832481.
      View in: PubMed
    191. Le QT, Giaccia AJ. HIF-alpha, a gender independent transcription factor. Clin Cancer Res. 2003 Jul; 9(7):2391-3. PMID: 12855609.
      View in: PubMed
    192. Hammond EM, Dorie MJ, Giaccia AJ. ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation. J Biol Chem. 2003 Apr 04; 278(14):12207-13. PMID: 12519769.
      View in: PubMed
    193. Yun Z, Giaccia AJ. Tumor deprivation of oxygen and tumor suppressor gene function. Methods Mol Biol. 2003; 223:485-504. PMID: 12777746.
      View in: PubMed
    194. Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res. 2003 Jan; 9(1):59-67. PMID: 12538452.
      View in: PubMed
    195. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002 Oct; 22(20):7004-14. PMID: 12242281.
      View in: PubMed
    196. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem. 2002 Oct 18; 277(42):40112-7. PMID: 12186875.
      View in: PubMed
    197. Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell. 2002 Aug; 2(2):139-48. PMID: 12204534.
      View in: PubMed
    198. Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science. 2002 Jul 26; 297(5581):471; discussion 471. PMID: 12142499.
      View in: PubMed
    199. Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB. Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):573-9. PMID: 12050099.
      View in: PubMed
    200. Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2002 Mar; 2(3):331-41. PMID: 11879638.
      View in: PubMed
    201. Hammond EM, Denko NC, Dorie MJ, Abraham RT, Giaccia AJ. Hypoxia links ATR and p53 through replication arrest. Mol Cell Biol. 2002 Mar; 22(6):1834-43. PMID: 11865061.
      View in: PubMed
    202. Shibata T, Giaccia AJ, Brown JM. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia. 2002 Jan-Feb; 4(1):40-8. PMID: 11922390.
      View in: PubMed
    GIACCIA's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description