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AMATO J. GIACCIA

TitleVisiting Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Cellular Biology
DivisionMolecular & Cellular Biology
AddressDept. of MCB, Mail Stop, BCM 130
Houston TX 77030
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    Collapse Research 
    Collapse research activities and funding
    T32CA009302     (ATTARDI, LAURA D)Sep 15, 1977 - Aug 31, 2023
    NIH/NCI
    Cancer Etiology, Prevention, Detection and Diagnosis
    Role: Co-Principal Investigator

    R01CA003353     (GIACCIA, AMATO J.)Dec 1, 1978 - Nov 30, 1994
    NIH/NCI
    EXPERIMENTAL RADIOTHERAPY - CELLULAR RESPONSES IN VIVO
    Role: Principal Investigator

    R01CA058838     (GIACCIA, AMATO J.)Feb 1, 1993 - Jan 31, 1996
    NIH/NCI
    MOLECULAR CYTOGENETICS OF PROSTATE CANCER
    Role: Principal Investigator

    R01CA064489     (GIACCIA, AMATO J.)May 3, 1996 - May 31, 2000
    NIH/NCI
    REGULATION OF P53 IN CERVICAL CARCINOMA BY HEAT/HYPOXIA
    Role: Principal Investigator

    P01CA067166     (GIACCIA, AMATO J.)Jun 15, 1996 - May 31, 2018
    NIH/NCI
    Tumor Hypoxia: Molecular Studies and Clinical Exploitation
    Role: Principal Investigator

    R01CA073832     (GIACCIA, AMATO J.)Dec 15, 1997 - Nov 30, 2000
    NIH/NCI
    MOLECULAR PHYSIOLOGY OF HYPOXIA INDUCED STRESS
    Role: Principal Investigator

    R01CA088480     (GIACCIA, AMATO J.)Jul 1, 2000 - Apr 30, 2010
    NIH/NCI
    Hypoxia and Gene Repression
    Role: Principal Investigator

    R37CA088480     (GIACCIA, AMATO J.)Jul 1, 2000 - Apr 30, 2015
    NIH/NCI
    Hypoxia and Gene Repression
    Role: Principal Investigator

    T32CA121940     (GIACCIA, AMATO J.)Jul 1, 2006 - Aug 31, 2019
    NIH/NCI
    Postdoctoral Training in the Radiation Scinces
    Role: Principal Investigator

    R01CA116685     (GIACCIA, AMATO J.)Sep 27, 2006 - Jul 31, 2012
    NIH/NCI
    CTGF in Pancreatic Tumor Growth
    Role: Principal Investigator

    R01AR065403     (SCHIPANI, ERNESTINA)Sep 26, 2013 - Aug 31, 2018
    NIH/NIAMS
    HIF-1alpha, a Survival and Differentiation Factor for Cartilage
    Role: Co-Principal Investigator

    R35CA197713     (GIACCIA, AMATO J.)Aug 1, 2015 - Jul 31, 2022
    NIH/NCI
    The Impact of Mitochondrial Repression and Lipid Accumulation by HIF on Tumor Growth
    Role: Principal Investigator

    R01CA198291     (GIACCIA, AMATO J.)Apr 1, 2016 - Mar 31, 2021
    NIH/NCI
    Preclinical Testing of a Novel Therapy Targeting AXL in Advanced Kidney Cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hu MS, Maan ZN, Leavitt T, Hong WX, Rennert RC, Marshall CD, Borrelli MR, Zhu TN, Esquivel M, Zimmermann A, McArdle A, Chung MT, Foster DS, Jones RE, Gurtner GC, Giaccia AJ, Lorenz HP, Weissman IL, Longaker MT. Wounds Inhibit Tumor Growth In Vivo. Ann Surg. 2019 Feb 27. PMID: 30829705.
      View in: PubMed
    2. Merceron C, Ranganathan K, Wang E, Tata Z, Makkapati S, Khan MP, Mangiavini L, Yao AQ, Castellini L, Levi B, Giaccia AJ, Schipani E. Hypoxia-inducible factor 2a is a negative regulator of osteoblastogenesis and bone mass accrual. Bone Res. 2019; 7:7. PMID: 30792937.
      View in: PubMed
    3. McGee HM, Jiang D, Soto-Pantoja DR, Nevler A, Giaccia AJ, Woodward WA. Targeting the Tumor Microenvironment in Radiation Oncology: Proceedings from the 2018 ASTRO-AACR Research Workshop. Clin Cancer Res. 2019 Feb 05. PMID: 30723144.
      View in: PubMed
    4. Jiang X, Tian W, Tu AB, Pasupneti S, Shuffle E, Dahms P, Zhang P, Cai H, Dinh TT, Liu B, Cain C, Giaccia AJ, Butcher EC, Simon MC, Semenza GL, Nicolls MR. Endothelial Hypoxia-Inducible Factor-2a Is Required for the Maintenance of Airway Microvasculature. Circulation. 2019 Jan 22; 139(4):502-517. PMID: 30586708.
      View in: PubMed
    5. Olcina MM, Balanis NG, Kim RK, Aksoy BA, Kodysh J, Thompson MJ, Hammerbacher J, Graeber TG, Giaccia AJ. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018 Dec 26; 25(13):3721-3732.e6. PMID: 30590044.
      View in: PubMed
    6. Chen X, Litzenburger UM, Wei Y, Schep AN, LaGory EL, Choudhry H, Giaccia AJ, Greenleaf WJ, Chang HY. Joint single-cell DNA accessibility and protein epitope profiling reveals environmental regulation of epigenomic heterogeneity. Nat Commun. 2018 11 02; 9(1):4590. PMID: 30389926.
      View in: PubMed
    7. Benej M, Hong X, Vibhute S, Scott S, Wu J, Graves E, Le QT, Koong AC, Giaccia AJ, Yu B, Chen CS, Papandreou I, Denko NC. Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism. Proc Natl Acad Sci U S A. 2018 10 16; 115(42):10756-10761. PMID: 30201710.
      View in: PubMed
    8. Rafat M, Aguilera TA, Vilalta M, Bronsart LL, Soto LA, von Eyben R, Golla MA, Ahrari Y, Melemenidis S, Afghahi A, Jenkins MJ, Kurian AW, Horst KC, Giaccia AJ, Graves EE. Macrophages Promote Circulating Tumor Cell-Mediated Local Recurrence following Radiotherapy in Immunosuppressed Patients. Cancer Res. 2018 Aug 01; 78(15):4241-4252. PMID: 29880480.
      View in: PubMed
    9. Olcina MM, Kim RK, Melemenidis S, Graves EE, Giaccia AJ. The tumour microenvironment links complement system dysregulation and hypoxic signalling?. Br J Radiol. 2018 May 15; 20180069. PMID: 29544344.
      View in: PubMed
    10. Shirato H, Le QT, Kobashi K, Prayongrat A, Takao S, Shimizu S, Giaccia A, Xing L, Umegaki K. Selection of external beam radiotherapy approaches for precise and accurate cancer treatment. J Radiat Res. 2018 Mar 01; 59(suppl_1):i2-i10. PMID: 29373709.
      View in: PubMed
    11. Yang Z, Zhang J, Jiang D, Khatri P, Solow-Cordero DE, Toesca DAS, Koumenis C, Denko NC, Giaccia AJ, Le QT, Koong AC. A Human Genome-Wide RNAi Screen Reveals Diverse Modulators that Mediate IRE1a-XBP1 Activation. Mol Cancer Res. 2018 05; 16(5):745-753. PMID: 29440447.
      View in: PubMed
    12. Ko SH, Nauta AC, Morrison SD, Hu MS, Zimmermann AS, Chung MT, Glotzbach JP, Wong VW, Walmsley GG, Peter Lorenz H, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. PHD-2 Suppression in Mesenchymal Stromal Cells Enhances Wound Healing. Plast Reconstr Surg. 2018 01; 141(1):55e-67e. PMID: 29280872.
      View in: PubMed
    13. LaGory EL, Giaccia AJ. Long-range hypoxia signaling in NAFLD. Nat Med. 2017 Nov 07; 23(11):1251-1252. PMID: 29117167.
      View in: PubMed
    14. Chiou SH, Risca VI, Wang GX, Yang D, Grüner BM, Kathiria AS, Ma RK, Vaka D, Chu P, Kozak M, Castellini L, Graves EE, Kim GE, Mourrain P, Koong AC, Giaccia AJ, Winslow MM. BLIMP1 Induces Transient Metastatic Heterogeneity in Pancreatic Cancer. Cancer Discov. 2017 10; 7(10):1184-1199. PMID: 28790031.
      View in: PubMed
    15. Johnson RW, Sowder ME, Giaccia AJ. Hypoxia and Bone Metastatic Disease. Curr Osteoporos Rep. 2017 08; 15(4):231-238. PMID: 28597139.
      View in: PubMed
    16. VandeKopple MJ, Wu J, Baer LA, Bal NC, Maurya SK, Kalyanasundaram A, Periasamy M, Stanford KI, Giaccia AJ, Denko NC, Papandreou I. Stress-responsive HILPDA is necessary for thermoregulation during fasting. J Endocrinol. 2017 Oct; 235(1):27-38. PMID: 28739822.
      View in: PubMed
    17. Giaccia A, Johnson RS. Lorenz Poellinger. Exp Cell Res. 2017 07 15; 356(2):115. PMID: 28622772.
      View in: PubMed
    18. Wu PH, Onodera Y, Ichikawa Y, Rankin EB, Giaccia AJ, Watanabe Y, Qian W, Hashimoto T, Shirato H, Nam JM. Targeting integrins with RGD-conjugated gold nanoparticles in radiotherapy decreases the invasive activity of breast cancer cells. Int J Nanomedicine. 2017; 12:5069-5085. PMID: 28860745.
      View in: PubMed
    19. Castellini L, Moon EJ, Razorenova OV, Krieg AJ, von Eyben R, Giaccia AJ. KDM4B/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage. Nucleic Acids Res. 2017 Apr 20; 45(7):3674-3692. PMID: 28073943.
      View in: PubMed
    20. Vilalta M, Hughes NP, Von Eyben R, Giaccia AJ, Graves EE. Patterns of Vasculature in Mouse Models of Lung Cancer Are Dependent on Location. Mol Imaging Biol. 2017 04; 19(2):215-224. PMID: 27709411.
      View in: PubMed
    21. Peinado H, Zhang H, Matei IR, Costa-Silva B, Hoshino A, Rodrigues G, Psaila B, Kaplan RN, Bromberg JF, Kang Y, Bissell MJ, Cox TR, Giaccia AJ, Erler JT, Hiratsuka S, Ghajar CM, Lyden D. Pre-metastatic niches: organ-specific homes for metastases. Nat Rev Cancer. 2017 05; 17(5):302-317. PMID: 28303905.
      View in: PubMed
    22. Aguilera TA, Giaccia AJ. Molecular Pathways: Oncologic Pathways and Their Role in T-cell Exclusion and Immune Evasion-A New Role for the AXL Receptor Tyrosine Kinase. Clin Cancer Res. 2017 Jun 15; 23(12):2928-2933. PMID: 28289089.
      View in: PubMed
    23. Weyandt JD, Thompson CB, Giaccia AJ, Rathmell WK. Metabolic Alterations in Cancer and Their Potential as Therapeutic Targets. Am Soc Clin Oncol Educ Book. 2017; 37:825-832. PMID: 28561705.
      View in: PubMed
    24. Aguilera TA, Rafat M, Castellini L, Shehade H, Kariolis MS, Hui AB, Stehr H, von Eyben R, Jiang D, Ellies LG, Koong AC, Diehn M, Rankin EB, Graves EE, Giaccia AJ. Reprogramming the immunological microenvironment through radiation and targeting Axl. Nat Commun. 2016 12 23; 7:13898. PMID: 28008921.
      View in: PubMed
    25. Kariolis MS, Miao YR, Diep A, Nash SE, Olcina MM, Jiang D, Jones DS, Kapur S, Mathews II, Koong AC, Rankin EB, Cochran JR, Giaccia AJ. Inhibition of the GAS6/AXL pathway augments the efficacy of chemotherapies. J Clin Invest. 2017 01 03; 127(1):183-198. PMID: 27893463.
      View in: PubMed
    26. Rankin EB, Giaccia AJ. The Receptor Tyrosine Kinase AXL in Cancer Progression. Cancers (Basel). 2016 Nov 09; 8(11). PMID: 27834845.
      View in: PubMed
    27. Chang AC, Ong SG, LaGory EL, Kraft PE, Giaccia AJ, Wu JC, Blau HM. Telomere shortening and metabolic compromise underlie dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2016 11 15; 113(46):13120-13125. PMID: 27799523.
      View in: PubMed
    28. Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Erratum: Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016 10 27; 18(11):1260. PMID: 27784904.
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    29. Johnson RW, Finger EC, Olcina MM, Vilalta M, Aguilera T, Miao Y, Merkel AR, Johnson JR, Sterling JA, Wu JY, Giaccia AJ. Induction of LIFR confers a dormancy phenotype in breast cancer cells disseminated to the bone marrow. Nat Cell Biol. 2016 10; 18(10):1078-1089. PMID: 27642788.
      View in: PubMed
    30. Jiang D, Lynch C, Medeiros BC, Liedtke M, Bam R, Tam AB, Yang Z, Alagappan M, Abidi P, Le QT, Giaccia AJ, Denko NC, Niwa M, Koong AC. Identification of Doxorubicin as an Inhibitor of the IRE1a-XBP1 Axis of the Unfolded Protein Response. Sci Rep. 2016 09 16; 6:33353. PMID: 27634301.
      View in: PubMed
    31. Olcina MM, Giaccia AJ. Reducing radiation-induced gastrointestinal toxicity - the role of the PHD/HIF axis. J Clin Invest. 2016 10 03; 126(10):3708-3715. PMID: 27548524.
      View in: PubMed
    32. Giaccia AJ. A New Chromatin-Cytoskeleton Link in Cancer. Mol Cancer Res. 2016 12; 14(12):1173-1175. PMID: 27528705.
      View in: PubMed
    33. Jiang D, Tam AB, Alagappan M, Hay MP, Gupta A, Kozak MM, Solow-Cordero DE, Lum PY, Denko NC, Giaccia AJ, Le QT, Niwa M, Koong AC. Acridine Derivatives as Inhibitors of the IRE1a-XBP1 Pathway Are Cytotoxic to Human Multiple Myeloma. Mol Cancer Ther. 2016 09; 15(9):2055-65. PMID: 27307600.
      View in: PubMed
    34. Rankin EB, Nam JM, Giaccia AJ. Hypoxia: Signaling the Metastatic Cascade. Trends Cancer. 2016 06; 2(6):295-304. PMID: 28741527.
      View in: PubMed
    35. Rankin EB, Giaccia AJ. Hypoxic control of metastasis. Science. 2016 Apr 08; 352(6282):175-80. PMID: 27124451; PMCID: PMC4898055.
    36. LaGory EL, Giaccia AJ. The ever-expanding role of HIF in tumour and stromal biology. Nat Cell Biol. 2016 Apr; 18(4):356-65. PMID: 27027486; PMCID: PMC4898054 [Available on 09/30/16].
    37. Leszczynska KB, Göttgens EL, Biasoli D, Olcina MM, Ient J, Anbalagan S, Bernhardt S, Giaccia AJ, Hammond EM. Mechanisms and consequences of ATMIN repression in hypoxic conditions: roles for p53 and HIF-1. Sci Rep. 2016 Feb 15; 6:21698. PMID: 26875667.
      View in: PubMed
    38. Sun RC, Koong A, Giaccia A, Denko NC. Measuring the Impact of Microenvironmental Conditions on Mitochondrial Dehydrogenase Activity in Cultured Cells. Adv Exp Med Biol. 2016; 899:113-20. PMID: 27325264; PMCID: PMC5017243 [Available on 01/01/17].
    39. Olcina MM, Giaccia AJ, Hammond EM. Isolation of Proteins on Nascent DNA in Hypoxia and Reoxygenation Conditions. Adv Exp Med Biol. 2016; 899:27-40. PMID: 27325260.
      View in: PubMed
    40. Ji J, Zöller B, Giaccia A, Haile R, Sundquist J, Sundquist K. Risk of breast cancer among patients with bioprosthetic or mechanical valve replacement: a population-based study in Sweden. Breast Cancer Res Treat. 2015 Nov; 154(2):369-75. PMID: 26476725.
      View in: PubMed
    41. Zhou L, Liu XD, Sun M, Zhang X, German P, Bai S, Ding Z, Tannir N, Wood CG, Matin SF, Karam JA, Tamboli P, Sircar K, Rao P, Rankin EB, Laird DA, Hoang AG, Walker CL, Giaccia AJ, Jonasch E. Targeting MET and AXL overcomes resistance to sunitinib therapy in renal cell carcinoma. Oncogene. 2016 05; 35(21):2687-97. PMID: 26364599.
      View in: PubMed
    42. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Sandusky G, Abadie J, Lyons KM, Giaccia AJ, Schipani E. Fibrosis and hypoxia-inducible factor-1a-dependent tumors of the soft tissue on loss of von Hippel-Lindau in mesenchymal progenitors. Am J Pathol. 2015 Nov; 185(11):3090-101. PMID: 26348575.
      View in: PubMed
    43. Pollom EL, Deng L, Pai RK, Brown JM, Giaccia A, Loo BW, Shultz DB, Le QT, Koong AC, Chang DT. Gastrointestinal Toxicities With Combined Antiangiogenic and Stereotactic Body Radiation Therapy. Int J Radiat Oncol Biol Phys. 2015 Jul 01; 92(3):568-76. PMID: 26068491; PMCID: PMC4816453.
    44. LaGory EL, Wu C, Taniguchi CM, Ding CC, Chi JT, von Eyben R, Scott DA, Richardson AD, Giaccia AJ. Suppression of PGC-1a Is Critical for Reprogramming Oxidative Metabolism in Renal Cell Carcinoma. Cell Rep. 2015 Jul 07; 12(1):116-127. PMID: 26119730; PMCID: PMC4518559.
    45. Wu C, Rankin EB, Castellini L, Alcudia JF, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Corrigendum: Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Jun 01; 29(11):1202. PMID: 26063577; PMCID: PMC4470287.
    46. Le QT, Shirato H, Giaccia AJ, Koong AC. Emerging Treatment Paradigms in Radiation Oncology. Clin Cancer Res. 2015 Aug 01; 21(15):3393-401. PMID: 25991820.
      View in: PubMed
    47. Wu C, Rankin EB, Castellini L, Alcudia JF, Fernandez-Alcudia J, LaGory EL, Andersen R, Rhodes SD, Wilson TL, Mohammad KS, Castillo AB, Guise TA, Schipani E, Giaccia AJ. Oxygen-sensing PHDs regulate bone homeostasis through the modulation of osteoprotegerin. Genes Dev. 2015 Apr 15; 29(8):817-31. PMID: 25846796; PMCID: PMC4403258.
    48. Aguilera TA, Giaccia AJ. The end of the hypoxic EPOch. Int J Radiat Oncol Biol Phys. 2015 Apr 01; 91(5):895-7. PMID: 25832683.
      View in: PubMed
    49. Finger EC, Castellini L, Rankin EB, Vilalta M, Krieg AJ, Jiang D, Banh A, Zundel W, Powell MB, Giaccia AJ. Hypoxic induction of AKAP12 variant 2 shifts PKA-mediated protein phosphorylation to enhance migration and metastasis of melanoma cells. Proc Natl Acad Sci U S A. 2015 Apr 07; 112(14):4441-6. PMID: 25792458; PMCID: PMC4394282.
    50. Jiang D, LaGory EL, Kenzelmann Brož D, Bieging KT, Brady CA, Link N, Abrams JM, Giaccia AJ, Attardi LD. Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function. Cell Rep. 2015 Feb 24; 10(7):1096-109. PMID: 25704813; PMCID: PMC4365998.
    51. Johnson RW, Schipani E, Giaccia AJ. HIF targets in bone remodeling and metastatic disease. Pharmacol Ther. 2015 Jun; 150:169-77. PMID: 25681658; PMCID: PMC4414805.
    52. Wu C, Giaccia AJ, Rankin EB. Osteoblasts: a novel source of erythropoietin. Curr Osteoporos Rep. 2014 Dec; 12(4):428-32. PMID: 25204993; PMCID: PMC4349388.
    53. Moon EJ, Giaccia A. Dual roles of NRF2 in tumor prevention and progression: possible implications in cancer treatment. Free Radic Biol Med. 2015 Feb; 79:292-9. PMID: 25458917; PMCID: PMC4339613.
    54. Merceron C, Mangiavini L, Robling A, Wilson TL, Giaccia AJ, Shapiro IM, Schipani E, Risbud MV. Loss of HIF-1a in the notochord results in cell death and complete disappearance of the nucleus pulposus. PLoS One. 2014; 9(10):e110768. PMID: 25338007; PMCID: PMC4206488.
    55. Kariolis MS, Miao YR, Jones DS, Kapur S, Mathews II, Giaccia AJ, Cochran JR. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Chem Biol. 2014 Nov; 10(11):977-83. PMID: 25242553; PMCID: PMC4372605.
    56. Kuo P, Bratman SV, Shultz DB, von Eyben R, Chan C, Wang Z, Say C, Gupta A, Loo BW, Giaccia AJ, Koong AC, Diehn M, Le QT. Galectin-1 mediates radiation-related lymphopenia and attenuates NSCLC radiation response. Clin Cancer Res. 2014 Nov 01; 20(21):5558-69. PMID: 25189484.
      View in: PubMed
    57. Rankin EB, Fuh KC, Castellini L, Viswanathan K, Finger EC, Diep AN, LaGory EL, Kariolis MS, Chan A, Lindgren D, Axelson H, Miao YR, Krieg AJ, Giaccia AJ. Direct regulation of GAS6/AXL signaling by HIF promotes renal metastasis through SRC and MET. Proc Natl Acad Sci U S A. 2014 Sep 16; 111(37):13373-8. PMID: 25187556; PMCID: PMC4169907.
    58. Giaccia AJ. Molecular radiobiology: the state of the art. J Clin Oncol. 2014 Sep 10; 32(26):2871-8. PMID: 25113768; PMCID: PMC4152715.
    59. Xiao N, Lin Y, Cao H, Sirjani D, Giaccia AJ, Koong AC, Kong CS, Diehn M, Le QT. Neurotrophic factor GDNF promotes survival of salivary stem cells. J Clin Invest. 2014 Aug; 124(8):3364-77. PMID: 25036711.
      View in: PubMed
    60. Vilalta M, Rafat M, Giaccia AJ, Graves EE. Recruitment of circulating breast cancer cells is stimulated by radiotherapy. Cell Rep. 2014 Jul 24; 8(2):402-9. PMID: 25017065.
      View in: PubMed
    61. Mangiavini L, Merceron C, Araldi E, Khatri R, Gerard-O'Riley R, Wilson TL, Rankin EB, Giaccia AJ, Schipani E. Loss of VHL in mesenchymal progenitors of the limb bud alters multiple steps of endochondral bone development. Dev Biol. 2014 Sep 01; 393(1):124-36. PMID: 24972088; PMCID: PMC4335807.
    62. Taniguchi CM, Miao YR, Diep AN, Wu C, Rankin EB, Atwood TF, Xing L, Giaccia AJ. PHD inhibition mitigates and protects against radiation-induced gastrointestinal toxicity via HIF2. Sci Transl Med. 2014 May 14; 6(236):236ra64. PMID: 24828078; PMCID: PMC4136475.
    63. Zimmermann AS, Morrison SD, Hu MS, Li S, Nauta A, Sorkin M, Meyer NP, Walmsley GG, Maan ZN, Chan DA, Gurtner GC, Giaccia AJ, Longaker MT. Epidermal or dermal specific knockout of PHD-2 enhances wound healing and minimizes ischemic injury. PLoS One. 2014; 9(4):e93373. PMID: 24695462; PMCID: PMC3973687.
    64. Koumenis C, Hammond E, Giaccia A. Tumor microenvironment and cellular stress: signaling, metabolism, imaging, and therapeutic targets. Preface. Adv Exp Med Biol. 2014; 772:v-viii. PMID: 24765667.
      View in: PubMed
    65. Bonnet M, Flanagan JU, Chan DA, Giaccia AJ, Hay MP. Identifying novel targets in renal cell carcinoma: design and synthesis of affinity chromatography reagents. Bioorg Med Chem. 2014 Jan 15; 22(2):711-20. PMID: 24387866.
      View in: PubMed
    66. Razorenova OV, Castellini L, Colavitti R, Edgington LE, Nicolau M, Huang X, Bedogni B, Mills EM, Bogyo M, Giaccia AJ. The apoptosis repressor with a CARD domain (ARC) gene is a direct hypoxia-inducible factor 1 target gene and promotes survival and proliferation of VHL-deficient renal cancer cells. Mol Cell Biol. 2014 Feb; 34(4):739-51. PMID: 24344197; PMCID: PMC3911479.
    67. Giaccia AJ. HIF-2: the missing link between obesity and cardiomyopathy. J Am Heart Assoc. 2013 Dec 16; 2(6):e000710. PMID: 24342999; PMCID: PMC3886772.
    68. Taniguchi CM, Finger EC, Krieg AJ, Wu C, Diep AN, LaGory EL, Wei K, McGinnis LM, Yuan J, Kuo CJ, Giaccia AJ. Cross-talk between hypoxia and insulin signaling through Phd3 regulates hepatic glucose and lipid metabolism and ameliorates diabetes. Nat Med. 2013 Oct; 19(10):1325-30. PMID: 24037093; PMCID: PMC4089950.
    69. Wei K, Piecewicz SM, McGinnis LM, Taniguchi CM, Wiegand SJ, Anderson K, Chan CW, Mulligan KX, Kuo D, Yuan J, Vallon M, Morton L, Lefai E, Simon MC, Maher JJ, Mithieux G, Rajas F, Annes J, McGuinness OP, Thurston G, Giaccia AJ, Kuo CJ. A liver Hif-2a-Irs2 pathway sensitizes hepatic insulin signaling and is modulated by Vegf inhibition. Nat Med. 2013 Oct; 19(10):1331-1337. PMID: 24037094; PMCID: PMC3795838.
    70. Schipani E, Wu C, Rankin EB, Giaccia AJ. Regulation of Bone Marrow Angiogenesis by Osteoblasts during Bone Development and Homeostasis. Front Endocrinol (Lausanne). 2013; 4:85. PMID: 23847596; PMCID: PMC3706978.
    71. Xiao N, Cao H, Chen CH, Kong CS, Ali R, Chan C, Sirjani D, Graves E, Koong A, Giaccia A, Mochly-Rosen D, Le QT. A novel aldehyde dehydrogenase-3 activator (Alda-89) protects submandibular gland function from irradiation without accelerating tumor growth. Clin Cancer Res. 2013 Aug 15; 19(16):4455-64. PMID: 23812668.
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    72. Finger EC, Cheng CF, Williams TR, Rankin EB, Bedogni B, Tachiki L, Spong S, Giaccia AJ, Powell MB. CTGF is a therapeutic target for metastatic melanoma. Oncogene. 2014 Feb 27; 33(9):1093-100. PMID: 23435419; PMCID: PMC3965577.
    73. LaGory EL, Giaccia AJ. A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth. Cell Cycle. 2013 Mar 01; 12(5):718-9. PMID: 23422857; PMCID: PMC3610718.
    74. Catalina-Rodriguez O, Kolukula VK, Tomita Y, Preet A, Palmieri F, Wellstein A, Byers S, Giaccia AJ, Glasgow E, Albanese C, Avantaggiati ML. The mitochondrial citrate transporter, CIC, is essential for mitochondrial homeostasis. Oncotarget. 2012 Oct; 3(10):1220-35. PMID: 23100451; PMCID: PMC3717962.
    75. Wu C, Rankin EB, Giaccia AJ. Blood and bones: osteoblastic HIF signaling regulates erythropoiesis. Cell Cycle. 2012 Jun 15; 11(12):2221-2. PMID: 22627672; PMCID: PMC3383578.
    76. Jonasch E, Futreal PA, Davis IJ, Bailey ST, Kim WY, Brugarolas J, Giaccia AJ, Kurban G, Pause A, Frydman J, Zurita AJ, Rini BI, Sharma P, Atkins MB, Walker CL, Rathmell WK. State of the science: an update on renal cell carcinoma. Mol Cancer Res. 2012 Jul; 10(7):859-80. PMID: 22638109; PMCID: PMC3399969.
    77. Krieg SA, Fan X, Hong Y, Sang QX, Giaccia A, Westphal LM, Lathi RB, Krieg AJ, Nayak NR. Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod. 2012 Sep; 18(9):442-50. PMID: 22505054; PMCID: PMC3431184.
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    174. Bernier J, Hall EJ, Giaccia A. Radiation oncology: a century of achievements. Nat Rev Cancer. 2004 09; 4(9):737-47. PMID: 15343280.
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    180. Soltys SG, Le QT, Shi G, Tibshirani R, Giaccia AJ, Koong AC. The use of plasma surface-enhanced laser desorption/ionization time-of-flight mass spectrometry proteomic patterns for detection of head and neck squamous cell cancers. Clin Cancer Res. 2004 Jul 15; 10(14):4806-12. PMID: 15269156.
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    184. Pfander D, Kobayashi T, Knight MC, Zelzer E, Chan DA, Olsen BR, Giaccia AJ, Johnson RS, Haase VH, Schipani E. Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development. Development. 2004 May; 131(10):2497-508. PMID: 15128677.
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    185. Bedogni B, O'Neill MS, Welford SM, Bouley DM, Giaccia AJ, Denko NC, Powell MB. Topical treatment with inhibitors of the phosphatidylinositol 3'-kinase/Akt and Raf/mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathways reduces melanoma development in severe combined immunodeficient mice. Cancer Res. 2004 Apr 01; 64(7):2552-60. PMID: 15059911.
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    186. Bemis L, Chan DA, Finkielstein CV, Qi L, Sutphin PD, Chen X, Stenmark K, Giaccia AJ, Zundel W. Distinct aerobic and hypoxic mechanisms of HIF-alpha regulation by CSN5. Genes Dev. 2004 Apr 01; 18(7):739-44. PMID: 15082527; PMCID: PMC387414.
    187. Sutphin PD, Chan DA, Giaccia AJ. Dead cells don't form tumors: HIF-dependent cytotoxins. Cell Cycle. 2004 Feb; 3(2):160-3. PMID: 14712081.
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    188. Swiersz LM, Giaccia AJ, Yun Z. Oxygen-dependent regulation of adipogenesis. Methods Enzymol. 2004; 381:387-95. PMID: 15063688.
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    190. Giaccia A, Siim BG, Johnson RS. HIF-1 as a target for drug development. Nat Rev Drug Discov. 2003 Oct; 2(10):803-11. PMID: 14526383.
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    193. Le QT, Giaccia AJ. HIF-alpha, a gender independent transcription factor. Clin Cancer Res. 2003 Jul; 9(7):2391-3. PMID: 12855609.
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    196. Le QT, Sutphin PD, Raychaudhuri S, Yu SC, Terris DJ, Lin HS, Lum B, Pinto HA, Koong AC, Giaccia AJ. Identification of osteopontin as a prognostic plasma marker for head and neck squamous cell carcinomas. Clin Cancer Res. 2003 Jan; 9(1):59-67. PMID: 12538452.
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    197. Yun Z, Giaccia AJ. Tumor deprivation of oxygen and tumor suppressor gene function. Methods Mol Biol. 2003; 223:485-504. PMID: 12777746.
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    198. Hudson CC, Liu M, Chiang GG, Otterness DM, Loomis DC, Kaper F, Giaccia AJ, Abraham RT. Regulation of hypoxia-inducible factor 1alpha expression and function by the mammalian target of rapamycin. Mol Cell Biol. 2002 Oct; 22(20):7004-14. PMID: 12242281; PMCID: PMC139825.
    199. Chan DA, Sutphin PD, Denko NC, Giaccia AJ. Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1alpha. J Biol Chem. 2002 Oct 18; 277(42):40112-7. PMID: 12186875.
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    200. Maecker HL, Yun Z, Maecker HT, Giaccia AJ. Epigenetic changes in tumor Fas levels determine immune escape and response to therapy. Cancer Cell. 2002 Aug; 2(2):139-48. PMID: 12204534.
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    201. Hammond EM, Giaccia AJ. Antiangiogenic therapy and p53. Science. 2002 Jul 26; 297(5581):471; discussion 471. PMID: 12142499.
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    202. Lluria-Prevatt M, Morreale J, Gregus J, Alberts DS, Kaper F, Giaccia A, Powell MB. Effects of perillyl alcohol on melanoma in the TPras mouse model. Cancer Epidemiol Biomarkers Prev. 2002 Jun; 11(6):573-9. PMID: 12050099.
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    203. Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell. 2002 Mar; 2(3):331-41. PMID: 11879638.
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    205. Liu SC, Minton NP, Giaccia AJ, Brown JM. Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis. Gene Ther. 2002 Feb; 9(4):291-6. PMID: 11896468.
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    206. Shibata T, Giaccia AJ, Brown JM. Hypoxia-inducible regulation of a prodrug-activating enzyme for tumor-specific gene therapy. Neoplasia. 2002 Jan-Feb; 4(1):40-8. PMID: 11922390; PMCID: PMC1503309.
    207. Popovici RM, Lu M, Bhatia S, Faessen GH, Giaccia AJ, Giudice LC. Hypoxia regulates insulin-like growth factor-binding protein 1 in human fetal hepatocytes in primary culture: suggestive molecular mechanisms for in utero fetal growth restriction caused by uteroplacental insufficiency. J Clin Endocrinol Metab. 2001 Jun; 86(6):2653-9. PMID: 11397868.
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    208. Chen EY, Mazure NM, Cooper JA, Giaccia AJ. Hypoxia activates a platelet-derived growth factor receptor/phosphatidylinositol 3-kinase/Akt pathway that results in glycogen synthase kinase-3 inactivation. Cancer Res. 2001 Mar 15; 61(6):2429-33. PMID: 11289110.
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    209. Green SL, Freiberg RA, Giaccia AJ. p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest. Mol Cell Biol. 2001 Feb; 21(4):1196-206. PMID: 11158306; PMCID: PMC99573.
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    212. Alarcon RM, Denko NC, Giaccia AJ. Genetic determinants that influence hypoxia-induced apoptosis. Novartis Found Symp. 2001; 240:115-28; discussion 128-32. PMID: 11727925.
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    213. Sugawara J, Tazuke SI, Suen LF, Powell DR, Kaper F, Giaccia AJ, Giudice LC. Regulation of insulin-like growth factor-binding protein 1 by hypoxia and 3',5'-cyclic adenosine monophosphate is additive in HepG2 cells. J Clin Endocrinol Metab. 2000 Oct; 85(10):3821-7. PMID: 11061545.
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    217. Laderoute KR, Alarcon RM, Brody MD, Calaoagan JM, Chen EY, Knapp AM, Yun Z, Denko NC, Giaccia AJ. Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor. Clin Cancer Res. 2000 Jul; 6(7):2941-50. PMID: 10914744.
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    218. Zundel W, Swiersz LM, Giaccia A. Caveolin 1-mediated regulation of receptor tyrosine kinase-associated phosphatidylinositol 3-kinase activity by ceramide. Mol Cell Biol. 2000 Mar; 20(5):1507-14. PMID: 10669728; PMCID: PMC85322.
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    220. Koong AC, Denko NC, Hudson KM, Schindler C, Swiersz L, Koch C, Evans S, Ibrahim H, Le QT, Terris DJ, Giaccia AJ. Candidate genes for the hypoxic tumor phenotype. Cancer Res. 2000 Feb 15; 60(4):883-7. PMID: 10706099.
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    221. Zundel W, Schindler C, Haas-Kogan D, Koong A, Kaper F, Chen E, Gottschalk AR, Ryan HE, Johnson RS, Jefferson AB, Stokoe D, Giaccia AJ. Loss of PTEN facilitates HIF-1-mediated gene expression. Genes Dev. 2000 Feb 15; 14(4):391-6. PMID: 10691731; PMCID: PMC316386.
    222. Denko N, Schindler C, Koong A, Laderoute K, Green C, Giaccia A. Epigenetic regulation of gene expression in cervical cancer cells by the tumor microenvironment. Clin Cancer Res. 2000 Feb; 6(2):480-7. PMID: 10690527.
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    223. Fox ME, Lemmon MJ, Giaccia AJ, Minton NP, Brown JM. Genetically modified clostridium for gene therapy of tumors. Methods Mol Med. 2000; 35:413-8. PMID: 21390820.
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    224. Alarcón R, Koumenis C, Geyer RK, Maki CG, Giaccia AJ. Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation. Cancer Res. 1999 Dec 15; 59(24):6046-51. PMID: 10626788.
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    225. Wouters BG, Denko NC, Giaccia AJ, Brown JM. A p53 and apoptotic independent role for p21waf1 in tumour response to radiation therapy. Oncogene. 1999 Nov 11; 18(47):6540-5. PMID: 10597257.
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    226. Chen EY, Fujinaga M, Giaccia AJ. Hypoxic microenvironment within an embryo induces apoptosis and is essential for proper morphological development. Teratology. 1999 Oct; 60(4):215-25. PMID: 10508975.
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    227. Popovici RM, Irwin JC, Giaccia AJ, Giudice LC. Hypoxia and cAMP stimulate vascular endothelial growth factor (VEGF) in human endometrial stromal cells: potential relevance to menstruation and endometrial regeneration. J Clin Endocrinol Metab. 1999 Jun; 84(6):2245-8. PMID: 10372740.
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    228. Laderoute KR, Mendonca HL, Calaoagan JM, Knapp AM, Giaccia AJ, Stork PJ. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible stress-activated protein kinase/c-Jun N-terminal protein kinase activity. J Biol Chem. 1999 Apr 30; 274(18):12890-7. PMID: 10212278.
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    230. Murphy BJ, Andrews GK, Bittel D, Discher DJ, McCue J, Green CJ, Yanovsky M, Giaccia A, Sutherland RM, Laderoute KR, Webster KA. Activation of metallothionein gene expression by hypoxia involves metal response elements and metal transcription factor-1. Cancer Res. 1999 Mar 15; 59(6):1315-22. PMID: 10096565.
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    231. Spicher A, Guicherit OM, Duret L, Aslanian A, Sanjines EM, Denko NC, Giaccia AJ, Blau HM. Highly conserved RNA sequences that are sensors of environmental stress. Mol Cell Biol. 1998 Dec; 18(12):7371-82. PMID: 9819424; PMCID: PMC109319.
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    233. Tazuke SI, Mazure NM, Sugawara J, Carland G, Faessen GH, Suen LF, Irwin JC, Powell DR, Giaccia AJ, Giudice LC. Hypoxia stimulates insulin-like growth factor binding protein 1 (IGFBP-1) gene expression in HepG2 cells: a possible model for IGFBP-1 expression in fetal hypoxia. Proc Natl Acad Sci U S A. 1998 Aug 18; 95(17):10188-93. PMID: 9707622; PMCID: PMC21483.
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    235. Green SL, Giaccia AJ. Tumor hypoxia and the cell cycle: implications for malignant progression and response to therapy. Cancer J Sci Am. 1998 Jul-Aug; 4(4):218-23. PMID: 9689978.
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    236. Zundel W, Giaccia A. Inhibition of the anti-apoptotic PI(3)K/Akt/Bad pathway by stress. Genes Dev. 1998 Jul 01; 12(13):1941-6. PMID: 9649498; PMCID: PMC316964.
    237. Lee JE, Kim CY, Giaccia AJ, Giffard RG. The E6 and E7 genes of human papilloma virus-type 16 protect primary astrocyte cultures from injury. Brain Res. 1998 Jun 08; 795(1-2):10-6. PMID: 9622584.
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    238. Rupnow BA, Murtha AD, Alarcon RM, Giaccia AJ, Knox SJ. Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy. Cancer Res. 1998 May 01; 58(9):1779-84. PMID: 9581811.
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    239. Brown JM, Giaccia AJ. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res. 1998 Apr 01; 58(7):1408-16. PMID: 9537241.
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    240. Xu L, Glassford AJ, Giaccia AJ, Giffard RG. Acidosis reduces neuronal apoptosis. Neuroreport. 1998 Mar 30; 9(5):875-9. PMID: 9579683.
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    241. Rupnow BA, Alarcon RM, Giaccia AJ, Knox SJ. p53 mediates apoptosis induced by c-Myc activation in hypoxic or gamma irradiated fibroblasts. Cell Death Differ. 1998 Feb; 5(2):141-7. PMID: 10200458.
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    242. Giaccia AJ, Brown JM, Wouters B, Denko N, Koumenis C. Cancer therapy and tumor physiology. Science. 1998 Jan 02; 279(5347):12-3. PMID: 9441397.
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    245. Mazure NM, Chen EY, Laderoute KR, Giaccia AJ. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element. Blood. 1997 Nov 01; 90(9):3322-31. PMID: 9345014.
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    246. Kim CY, Tsai MH, Osmanian C, Graeber TG, Lee JE, Giffard RG, DiPaolo JA, Peehl DM, Giaccia AJ. Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions. Cancer Res. 1997 Oct 01; 57(19):4200-4. PMID: 9331075.
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    247. Lemmon MJ, van Zijl P, Fox ME, Mauchline ML, Giaccia AJ, Minton NP, Brown JM. Anaerobic bacteria as a gene delivery system that is controlled by the tumor microenvironment. Gene Ther. 1997 Aug; 4(8):791-6. PMID: 9338007.
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    248. Denko N, Chen E, Laderoute K, Stambrook P, Giaccia A. Protease inhibitor TPCK represses Ha-ras (Val12) transformation and nuclear factor-kappa B activation. Int J Oncol. 1997 May; 10(5):895-900. PMID: 21533459.
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    249. Fried LM, Koumenis C, Peterson SR, Green SL, van Zijl P, Allalunis-Turner J, Chen DJ, Fishel R, Giaccia AJ, Brown JM, Kirchgessner CU. The DNA damage response in DNA-dependent protein kinase-deficient SCID mouse cells: replication protein A hyperphosphorylation and p53 induction. Proc Natl Acad Sci U S A. 1996 Nov 26; 93(24):13825-30. PMID: 8943020; PMCID: PMC19439.
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    251. Mazure NM, Chen EY, Yeh P, Laderoute KR, Giaccia AJ. Oncogenic transformation and hypoxia synergistically act to modulate vascular endothelial growth factor expression. Cancer Res. 1996 Aug 01; 56(15):3436-40. PMID: 8758908.
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    252. Laderoute K, Calaoagan J, Mendonca H, Ausserer W, Chen E, Giaccia A, Sutherland R. Early responses of SiHa human squamous carcinoma cells to hypoxic signals. Int J Oncol. 1996 May; 8(5):875-82. PMID: 21544440.
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    253. Fox ME, Lemmon MJ, Mauchline ML, Davis TO, Giaccia AJ, Minton NP, Brown JM. Anaerobic bacteria as a delivery system for cancer gene therapy: in vitro activation of 5-fluorocytosine by genetically engineered clostridia. Gene Ther. 1996 Feb; 3(2):173-8. PMID: 8867865.
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    256. Kapp DS, Giaccia AJ. New directions for radiation biology research in cancer of the uterine cervix. J Natl Cancer Inst Monogr. 1996; (21):131-9. PMID: 9023843.
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    258. Minton NP, Mauchline ML, Lemmon MJ, Brehm JK, Fox M, Michael NP, Giaccia A, Brown JM. Chemotherapeutic tumour targeting using clostridial spores. FEMS Microbiol Rev. 1995 Oct; 17(3):357-64. PMID: 7576773.
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    259. Girinsky T, Koumenis C, Graeber TG, Peehl DM, Giaccia AJ. Attenuated response of p53 and p21 in primary cultures of human prostatic epithelial cells exposed to DNA-damaging agents. Cancer Res. 1995 Sep 01; 55(17):3726-31. PMID: 7543816.
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    261. Saad AH, Kuo SS, Koong AC, Hahn GM, Giaccia AJ. Modulation of potassium channels by protein tyrosine kinase inhibitors. J Cell Physiol. 1994 Oct; 161(1):142-8. PMID: 7929599.
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    263. Denko NC, Giaccia AJ, Stringer JR, Stambrook PJ. The human Ha-ras oncogene induces genomic instability in murine fibroblasts within one cell cycle. Proc Natl Acad Sci U S A. 1994 May 24; 91(11):5124-8. PMID: 8197195; PMCID: PMC43944.
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    265. Mivechi NF, Koong AC, Giaccia AJ, Hahn GM. Analysis of HSF-1 phosphorylation in A549 cells treated with a variety of stresses. Int J Hyperthermia. 1994 May-Jun; 10(3):371-9. PMID: 7930803.
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    266. Koong AC, Auger EA, Chen EY, Giaccia AJ. The regulation of GRP78 and messenger RNA levels by hypoxia is modulated by protein kinase C activators and inhibitors. Radiat Res. 1994 Apr; 138(1 Suppl):S60-3. PMID: 8146329.
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    267. Koong AC, Chen EY, Giaccia AJ. Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues. Cancer Res. 1994 Mar 15; 54(6):1425-30. PMID: 8137243.
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    268. Koong AC, Chen EY, Lee AS, Brown JM, Giaccia AJ. Increased cytotoxicity of chronic hypoxic cells by molecular inhibition of GRP78 induction. Int J Radiat Oncol Biol Phys. 1994 Feb 01; 28(3):661-6. PMID: 8113109.
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    269. Brown JM, Giaccia AJ. Tumour hypoxia: the picture has changed in the 1990s. Int J Radiat Biol. 1994 Jan; 65(1):95-102. PMID: 7905916.
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    270. Alvarez L, Evans JW, Wilks R, Lucas JN, Brown JM, Giaccia AJ. Chromosomal radiosensitivity at intrachromosomal telomeric sites. Genes Chromosomes Cancer. 1993 Sep; 8(1):8-14. PMID: 7691162.
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    271. Koong AC, Giaccia AJ, Hahn GM, Saad AH. Activation of potassium channels by hypoxia and reoxygenation in the human lung adenocarcinoma cell line A549. J Cell Physiol. 1993 Aug; 156(2):341-7. PMID: 8344990.
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    272. Auger EA, Giaccia AJ, Hahn GM. Heat sensitivity of bleomycin-sensitive CHO derivatives is not due to improper initialization of heat shock response. Int J Hyperthermia. 1993 Mar-Apr; 9(2):275-84. PMID: 7682247.
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    273. Kuo SS, Saad AH, Koong AC, Hahn GM, Giaccia AJ. Potassium-channel activation in response to low doses of gamma-irradiation involves reactive oxygen intermediates in nonexcitatory cells. Proc Natl Acad Sci U S A. 1993 Feb 01; 90(3):908-12. PMID: 8430104; PMCID: PMC45779.
    274. Abella Columna E, Giaccia AJ, Evans JW, Yates BL, Morgan WF. Analysis of restriction enzyme-induced chromosomal aberrations by fluorescence in situ hybridization. Environ Mol Mutagen. 1993; 22(1):26-33. PMID: 8393403.
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    275. Kim CY, Giaccia AJ, Strulovici B, Brown JM. Differential expression of protein kinase C epsilon protein in lung cancer cell lines by ionising radiation. Br J Cancer. 1992 Nov; 66(5):844-9. PMID: 1329908; PMCID: PMC1977970.
    276. Giaccia AJ, Schwartz J, Shieh J, Brown JM. The use of asymmetric-field inversion gel electrophoresis to predict tumor cell radiosensitivity. Radiother Oncol. 1992 Aug; 24(4):231-8. PMID: 1410578.
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    277. Giaccia AJ, Biedermann KA, Tosto LM, Minchinton AI, Kovacs MS, Brown JM. Characterization of a CHO cell line resistant to killing by the hypoxic cell cytotoxin SR 4233. Int J Radiat Oncol Biol Phys. 1992; 22(4):681-4. PMID: 1544836.
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    278. Cholon A, Giaccia AJ, Lewis AD, Hickson I, Brown JM. What role do glutathione S-transferases play in the cellular response to ionizing radiation? Int J Radiat Oncol Biol Phys. 1992; 22(4):759-63. PMID: 1544849.
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    279. Giaccia AJ, Auger EA, Koong A, Terris DJ, Minchinton AI, Hahn GM, Brown JM. Activation of the heat shock transcription factor by hypoxia in normal and tumor cell lines in vivo and in vitro. Int J Radiat Oncol Biol Phys. 1992; 23(4):891-7. PMID: 1618682.
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    280. Giaccia AJ, Lewis AD, Denko NC, Cholon A, Evans JW, Waldren CA, Stamato TD, Brown JM. The hypersensitivity of the Chinese hamster ovary variant BL-10 to bleomycin killing is due to a lack of glutathione S-transferase-alpha activity. Cancer Res. 1991 Aug 15; 51(16):4463-9. PMID: 1714344.
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    281. Giaccia AJ, Shieh J, Cholon A, Brown JM. Biochemical evidence for two different mechanisms for bleomycin-induced cell killing. Mutat Res. 1991 Jun; 263(2):69-75. PMID: 1710776.
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    282. Anderson RL, Fong KJ, Gabriele T, Lavagnini P, Hahn GM, Evans JW, Waldren CA, Stamato TD, Giaccia AJ. Loss of the intrinsic heat resistance of human cells and changes in Mr 70,000 heat shock protein expression in human x hamster hybrids. Cancer Res. 1991 May 15; 51(10):2636-41. PMID: 2021941.
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    283. Evans JW, Chang JA, Giaccia AJ, Pinkel D, Brown JM. The use of fluorescence in situ hybridisation combined with premature chromosome condensation for the identification of chromosome damage. Br J Cancer. 1991 Apr; 63(4):517-21. PMID: 2021536; PMCID: PMC1972339.
    284. Biedermann KA, Sun JR, Giaccia AJ, Tosto LM, Brown JM. scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair. Proc Natl Acad Sci U S A. 1991 Feb 15; 88(4):1394-7. PMID: 1996340; PMCID: PMC51024.
    285. Giaccia AJ, Evans JW, Brown JM. Use of fluorescent in situ hybridization to detect chromosomal rearrangements in somatic cell hybrids. Genes Chromosomes Cancer. 1990 Sep; 2(3):248-51. PMID: 2078516.
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    286. Giaccia AJ, Denko N, MacLaren R, Mirman D, Waldren C, Hart I, Stamato TD. Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant. Am J Hum Genet. 1990 Sep; 47(3):459-69. PMID: 1697445; PMCID: PMC1683886.
    287. Giaccia AJ, MacLaren RA, Denko N, Nicolaou D, Stamato TD. Increased sensitivity to killing by restriction enzymes in the XR-1 DNA double-strand break repair-deficient mutant. Mutat Res. 1990 Jul; 236(1):67-76. PMID: 2164147.
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    288. Bahari IB, Bedford JS, Giaccia AJ, Stamato TD. Measurement of the relative proportion of symmetrical and asymmetrical chromosome-type interchanges induced by gamma radiation in human-hamster hybrid cells. Radiat Res. 1990 Jul; 123(1):105-7. PMID: 2371375.
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    289. Hentosh P, Collins AR, Correll L, Fornace AJ, Giaccia A, Waldren CA. Genetic and biochemical characterization of the CHO-UV-1 mutant defective in postreplication recovery of DNA. Cancer Res. 1990 Apr 15; 50(8):2356-62. PMID: 2317821.
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    290. Dasgupta P, Linnenbach AJ, Giaccia AJ, Stamato TD, Reddy EP. Molecular cloning of the breakpoint region on chromosome 6 in cutaneous malignant melanoma: evidence for deletion in the c-myb locus and translocation of a segment of chromosome 12. Oncogene. 1989 Oct; 4(10):1201-5. PMID: 2677917.
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    291. Stamato TD, Richardson E, Ianacone J, MacLaren RA, Denko N, Giaccia A. Isolation and characterization of glucose-6-phosphate dehydrogenase-deficient Chinese hamster cells derived from pure mutant colonies. Mutagenesis. 1989 Jul; 4(4):259-64. PMID: 2674604.
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    292. Denko N, Giaccia A, Peters B, Stamato TD. An asymmetric field inversion gel electrophoresis method for the separation of large DNA molecules. Anal Biochem. 1989 Apr; 178(1):172-6. PMID: 2729570.
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    293. Giaccia AJ, Richardson E, Denko N, Stamato TD. Genetic analysis of XR-1 mutation in hamster and human hybrids. Somat Cell Mol Genet. 1989 Jan; 15(1):71-7. PMID: 2916163.
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    294. Stamato TD, Dipatri A, Giaccia A. Cell-cycle-dependent repair of potentially lethal damage in the XR-1 gamma-ray-sensitive Chinese hamster ovary cell. Radiat Res. 1988 Aug; 115(2):325-33. PMID: 3406371.
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    295. Stamato TD, Peters B, Patil P, Denko N, Weinstein R, Giaccia A. Isolation and characterization of bleomycin-sensitive Chinese hamster ovary cells. Cancer Res. 1987 Mar 15; 47(6):1588-92. PMID: 2434221.
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    296. Stamato T, Weinstein R, Peters B, Hu J, Doherty B, Giaccia A. Delayed mutation in Chinese hamster cells. Somat Cell Mol Genet. 1987 Jan; 13(1):57-65. PMID: 3468633.
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    297. Giaccia A, Weinstein R, Hu J, Stamato TD. Cell cycle-dependent repair of double-strand DNA breaks in a gamma-ray-sensitive Chinese hamster cell. Somat Cell Mol Genet. 1985 Sep; 11(5):485-91. PMID: 3862244.
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    298. Stamato TD, Weinstein R, Giaccia A. Timing of mutation-fixation events in ethyl methane sulfonate-treated Chinese hamster cells. Somat Cell Mol Genet. 1984 Jul; 10(4):429-34. PMID: 6589795.
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    299. Stamato TD, Weinstein R, Giaccia A, Mackenzie L. Isolation of cell cycle-dependent gamma ray-sensitive Chinese hamster ovary cell. Somatic Cell Genet. 1983 Mar; 9(2):165-73. PMID: 6836453.
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