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NIDHI SAHNI

TitleAssistant Professor
InstitutionMD Anderson
DepartmentSystems Biology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pan X, Coban Akdemir ZH, Gao R, Jiang X, Sheynkman GM, Wu E, Huang JH, Sahni N, Yi SS. AD-Syn-Net: systematic identification of Alzheimer's disease-associated mutation and co-mutation vulnerabilities via deep learning. Brief Bioinform. 2023 Feb 08. PMID: 36752347.
      Citations:    Fields:    
    2. Pan X, Yun J, Coban Akdemir ZH, Jiang X, Wu E, Huang JH, Sahni N, Yi SS. AI-DrugNet: A network-based deep learning model for drug repurposing and combination therapy in neurological disorders. Comput Struct Biotechnol J. 2023; 21:1533-1542. PMID: 36879885; PMCID: PMC9984442.
      Citations:    
    3. Amici DR, Cingoz H, Alasady MJ, Alhayek S, Phoumyvong CM, Sahni N, Yi SS, Mendillo ML. The HAPSTR2 retrogene buffers stress signaling and resilience in mammals. Nat Commun. 2023 01 11; 14(1):152. PMID: 36631436; PMCID: PMC9834230.
      Citations:    Fields:    Translation:AnimalsCells
    4. Hua X, Li Y, Pentaparthi SR, McGrail DJ, Zou R, Guo L, Shrawat A, Cirillo KM, Li Q, Bhat A, Xu M, Qi D, Singh A, McGrath F, Andrews S, Aung KL, Das J, Zhou Y, Lodi A, Mills GB, Eckhardt SG, Mendillo ML, Tiziani S, Wu E, Huang JH, Sahni N, Yi SS. Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer. Cancer Res. 2023 01 04; 83(1):59-73. PMID: 36265133; PMCID: PMC9811166.
      Citations:    
    5. Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, Sahni N, McGrail DJ, Bernatchez C, Davies M, Li Y, Chen R, Yi SS, Chen Y, Yee C, Chen K, Peng W. Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. NAR Cancer. 2022 Dec; 4(4):zcac038. PMID: 36518525; PMCID: PMC9732527.
      Citations:    
    6. Yan G, Luna A, Wang H, Bozorgui B, Li X, Sanchez M, Dereli Z, Kahraman N, Kara G, Chen X, Zheng C, McGrail D, Sahni N, Lu Y, Babur O, Cokol M, Lim B, Ozpolat B, Sander C, Mills GB, Korkut A. BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer. Cell Rep. 2022 09 13; 40(11):111304. PMID: 36103824; PMCID: PMC9523722.
      Citations:    
    7. Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N, Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N. Biomolecular Condensation: A New Phase in Cancer Research. Cancer Discov. 2022 09 02; 12(9):2031-2043. PMID: 35852417; PMCID: PMC9437557.
      Citations:    Fields:    
    8. Pan X, Burgman B, Wu E, Huang JH, Sahni N, Stephen Yi S, Pan X, Burgman B, Wu E, Huang JH, Sahni N, Stephen Yi S. i-Modern: Integrated multi-omics network model identifies potential therapeutic targets in glioma by deep learning with interpretability. Comput Struct Biotechnol J. 2022; 20:3511-3521. PMID: 35860408; PMCID: PMC9284388.
      Citations:    
    9. Ningappa M, Rahman SA, Higgs BW, Ashokkumar CS, Sahni N, Sindhi R, Das J, Ningappa M, Rahman SA, Higgs BW, Ashokkumar CS, Sahni N, Sindhi R, Das J. A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation. Cell Rep Med. 2022 04 19; 3(4):100605. PMID: 35492246; PMCID: PMC9044102.
      Citations:    Fields:    Translation:Humans
    10. Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H, Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H. A functional genomic approach to actionable gene fusions for precision oncology. Sci Adv. 2022 02 11; 8(6):eabm2382. PMID: 35138907; PMCID: PMC8827659.
      Citations:    Fields:    Translation:Humans
    11. Guo L, Li Y, Cirillo KM, Marick RA, Su Z, Yin X, Hua X, Mills GB, Sahni N, Yi SS, Guo L, Li Y, Cirillo KM, Marick RA, Su Z, Yin X, Hua X, Mills GB, Sahni N, Yi SS. mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity. Brief Bioinform. 2021 09 02; 22(5). PMID: 33855356; PMCID: PMC8579161.
      Citations: 4     Fields:    Translation:HumansCells
    12. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 03 04; 184(5):1142-1155. PMID: 33667368; PMCID: PMC8066437.
      Citations: 23     Fields:    Translation:HumansAnimals
    13. Li Y, Burgman B, Khatri IS, Pentaparthi SR, Su Z, McGrail DJ, Li Y, Wu E, Eckhardt SG, Sahni N, Yi SS, Li Y, Burgman B, Khatri IS, Pentaparthi SR, Su Z, McGrail DJ, Li Y, Wu E, Eckhardt SG, Sahni N, Yi SS. e-MutPath: computational modeling reveals the functional landscape of genetic mutations rewiring interactome networks. Nucleic Acids Res. 2021 01 11; 49(1):e2. PMID: 33211847; PMCID: PMC7797045.
      Citations: 2     Fields:    Translation:HumansCells
    14. Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS, Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS. Integrated Genomic Characterization of the Human Immunome in Cancer. Cancer Res. 2020 11 01; 80(21):4854-4867. PMID: 32855206; PMCID: PMC7642109.
      Citations: 4     Fields:    Translation:HumansCells
    15. Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, Lam T, Pilie PG, Zhu H, Beckermann KE, Haake SM, Isgandrova S, Martinez-Moczygemba M, Sahni N, Tannir NM, Lin SY, Rathmell WK, Jonasch E, Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, Lam T, Pilie PG, Zhu H, Beckermann KE, Haake SM, Isgandrova S, Martinez-Moczygemba M, Sahni N, Tannir NM, Lin SY, Rathmell WK, Jonasch E. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020 05 01; 11(1):2135. PMID: 32358509; PMCID: PMC7195420.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    16. Daniels J, Doukas PG, Escala MEM, Ringbloom KG, Shih DJH, Yang J, Tegtmeyer K, Park J, Thomas JJ, Selli ME, Altunbulakli C, Gowthaman R, Mo SH, Jothishankar B, Pease DR, Pro B, Abdulla FR, Shea C, Sahni N, Gru AA, Pierce BG, Louissaint A, Guitart J, Choi J, Daniels J, Doukas PG, Escala MEM, Ringbloom KG, Shih DJH, Yang J, Tegtmeyer K, Park J, Thomas JJ, Selli ME, Altunbulakli C, Gowthaman R, Mo SH, Jothishankar B, Pease DR, Pro B, Abdulla FR, Shea C, Sahni N, Gru AA, Pierce BG, Louissaint A, Guitart J, Choi J. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas. Nat Commun. 2020 04 14; 11(1):1806. PMID: 32286303; PMCID: PMC7156460.
      Citations: 15     Fields:    Translation:HumansCells
    17. McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY, McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY. Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Cancer Cell. 2020 03 16; 37(3):371-386.e12. PMID: 32109374; PMCID: PMC7337255.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    18. Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB, Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell. 2019 06 10; 35(6):851-867.e7. PMID: 31185210; PMCID: PMC6642675.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    19. Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N, Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N. MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. Hepatology. 2019 08; 70(2):532-546. PMID: 30153342; PMCID: PMC6538468.
      Citations: 18     Fields:    Translation:Humans
    20. Ip CKM, Ng PKS, Jeong KJ, Shao SH, Ju Z, Leonard PG, Hua X, Vellano CP, Woessner R, Sahni N, Scott KL, Mills GB, Ip CKM, Ng PKS, Jeong KJ, Shao SH, Ju Z, Leonard PG, Hua X, Vellano CP, Woessner R, Sahni N, Scott KL, Mills GB. Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies. Nat Commun. 2018 11 02; 9(1):4583. PMID: 30389923; PMCID: PMC6214970.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    21. Lu J, Xu J, Li J, Pan T, Bai J, Wang L, Jin X, Lin X, Zhang Y, Li Y, Sahni N, Li X, Lu J, Xu J, Li J, Pan T, Bai J, Wang L, Jin X, Lin X, Zhang Y, Li Y, Sahni N, Li X. FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators. Nucleic Acids Res. 2018 11 02; 46(19):10019-10033. PMID: 30102398; PMCID: PMC6212842.
      Citations: 4     Fields:    Translation:HumansCells
    22. Li Y, McGrail DJ, Xu J, Mills GB, Sahni N, Yi S, Li Y, McGrail DJ, Xu J, Mills GB, Sahni N, Yi S. Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation. Trends Biochem Sci. 2018 08; 43(8):576-592. PMID: 29941230; PMCID: PMC6215597.
      Citations: 8     Fields:    Translation:HumansCells
    23. Li Y, McGrail DJ, Latysheva N, Yi S, Babu MM, Sahni N, Li Y, McGrail DJ, Latysheva N, Yi S, Babu MM, Sahni N. Pathway perturbations in signaling networks: Linking genotype to phenotype. Semin Cell Dev Biol. 2020 03; 99:3-11. PMID: 29738884; PMCID: PMC6230320.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    24. McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N, McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N. Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. Nat Commun. 2018 04 03; 9(1):1317. PMID: 29615613; PMCID: PMC5882811.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    25. Ng PK, Li J, Jeong KJ, Shao S, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Gao J, Tokheim C, Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Schultz N, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB, Ng PK, Li J, Jeong KJ, Shao S, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Gao J, Tokheim C, Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Schultz N, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB, Gao J, Schultz N. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018 03 12; 33(3):450-462.e10. PMID: 29533785; PMCID: PMC5926201.
      Citations: 78     Fields:    Translation:Humans
    26. Li Y, Li L, Wang Z, Pan T, Sahni N, Jin X, Wang G, Li J, Zheng X, Zhang Y, Xu J, Yi S, Li X, Li Y, Li L, Wang Z, Pan T, Sahni N, Jin X, Wang G, Li J, Zheng X, Zhang Y, Xu J, Yi S, Li X. LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations. Nucleic Acids Res. 2018 02 16; 46(3):1113-1123. PMID: 29325141; PMCID: PMC5815097.
      Citations: 49     Fields:    Translation:HumansCells
    27. Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S, Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S. Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer. Cell Rep. 2017 Oct 17; 21(3):798-812. PMID: 29045845; PMCID: PMC5689467.
      Citations: 23     Fields:    Translation:HumansCells
    28. Yi S, Liu NN, Hu L, Wang H, Sahni N, Yi S, Liu NN, Hu L, Wang H, Sahni N. Base-resolution stratification of cancer mutations using functional variomics. Nat Protoc. 2017 Nov; 12(11):2323-2341. PMID: 28981122; PMCID: PMC6145840.
      Citations: 3     Fields:    Translation:HumansCells
    29. Yi S, Sahni N, Yi S, Sahni N. Regulome networks and mutational landscape in liver cancer: An informative path to precision medicine. Hepatology. 2017 07; 66(1):280-282. PMID: 28422313; PMCID: PMC6129387.
      Citations:    Fields:    Translation:Humans
    30. Yi S, Lin S, Li Y, Zhao W, Mills GB, Sahni N, Yi S, Lin S, Li Y, Zhao W, Mills GB, Sahni N. Functional variomics and network perturbation: connecting genotype to phenotype in cancer. Nat Rev Genet. 2017 07; 18(7):395-410. PMID: 28344341; PMCID: PMC6020840.
      Citations: 40     Fields:    Translation:Humans
    31. Karras GI, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S, Karras GI, Yi S, Sahni N, Fischer M, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S, Fischer M. HSP90 Shapes the Consequences of Human Genetic Variation. Cell. 2017 Feb 23; 168(5):856-866.e12. PMID: 28215707; PMCID: PMC5325763.
      Citations: 43     Fields:    Translation:HumansCells
    32. Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S, Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Syst. 2017 02 22; 4(2):242-250.e4. PMID: 28131823; PMCID: PMC5578869.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    33. Li Y, Sahni N, Yi S, Li Y, Sahni N, Yi S. Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures. Oncotarget. 2016 Nov 29; 7(48):78841-78849. PMID: 27791983; PMCID: PMC5346681.
      Citations: 7     Fields:    Translation:HumansCells
    34. Yi S, Chen S, Zhang L, Sahni N, Yi S, Chen S, Zhang L, Sahni N. Signal Transduction and Regulation: Insights into Evolution. Biomed Res Int. 2016; 2016:8604245. PMID: 27525280; PMCID: PMC4971294.
      Citations:    Fields:    Translation:HumansAnimalsCells
    35. Lin S, Yin YA, Jiang X, Sahni N, Yi S, Lin S, Yin YA, Jiang X, Sahni N, Yi S. Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. Biomed Res Int. 2016; 2016:6186281. PMID: 27403431; PMCID: PMC4923561.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    36. Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP, Yachie N, Petsalaki E, Mellor JC, Weile J, Jacob Y, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Braun P, Stagljar I, Hao T, Calderwood MA, Pelletier L, Aloy P, Hill DE, Vidal M, Roth FP, Jacob Y, Braun P, Aloy P. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22; 12(4):863. PMID: 27107012; PMCID: PMC4848762.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    37. Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML, Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Gordân R, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML, Gord?n R. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science. 2016 Mar 25; 351(6280):1450-1454. PMID: 27013732; PMCID: PMC4825693.
      Citations: 61     Fields:    Translation:HumansCells
    38. Sun S, Yang F, Tan G, Costanzo M, Oughtred R, Hirschman J, Theesfeld CL, Bansal P, Sahni N, Yi S, Yu A, Tyagi T, Tie C, Hill DE, Vidal M, Andrews BJ, Boone C, Dolinski K, Roth FP, Sun S, Yang F, Tan G, Costanzo M, Oughtred R, Hirschman J, Theesfeld CL, Bansal P, Sahni N, Yi S, Yu A, Tyagi T, Tie C, Hill DE, Vidal M, Andrews BJ, Boone C, Dolinski K, Roth FP. An extended set of yeast-based functional assays accurately identifies human disease mutations. Genome Res. 2016 05; 26(5):670-80. PMID: 26975778; PMCID: PMC4864455.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    39. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M, Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Sun S, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Trigg SA, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Aloy P, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M, Sun S, Aloy P, Wanamaker SA. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 02 11; 164(4):805-17. PMID: 26871637; PMCID: PMC4882190.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    40. Wang Y, Sahni N, Vidal M, Wang Y, Sahni N, Vidal M. Global Edgetic Rewiring in Cancer Networks. Cell Syst. 2015 Oct 28; 1(4):251-3. PMID: 27136053.
      Citations: 5     Fields:    
    41. Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M, Sahni N, Yi S, Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Yang F, Peng J, Weile J, Karras GI, Wang Y, Kovács IA, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Sharma A, Liu YY, Yachie N, Zhong Q, Shen Y, Palagi A, San-Miguel A, Fan C, Balcha D, Dricot A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Calderwood MA, Jacob Y, Cusick ME, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Berger B, Barabási AL, Charloteaux B, Hill DE, Hao T, Roth FP, Xia Y, Walhout AJM, Lindquist S, Vidal M, Sahni N, Yi S, Yang F, Weile J, Wang Y, Kov?cs IA, Sharma A, Yachie N, Shen Y, Fan C, Balcha D, Dricot A, Calderwood MA, Jacob Y, Cusick ME, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Vidal M. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23; 161(3):647-660. PMID: 25910212; PMCID: PMC4441215.
      Citations: 206     Fields:    Translation:HumansCells
    42. Fuxman Bass JI, Sahni N, Shrestha S, Garcia-Gonzalez A, Mori A, Bhat N, Yi S, Hill DE, Vidal M, Walhout AJM, Fuxman Bass JI, Sahni N, Shrestha S, Garcia-Gonzalez A, Mori A, Bhat N, Yi S, Hill DE, Vidal M, Walhout AJM. Human gene-centered transcription factor networks for enhancers and disease variants. Cell. 2015 Apr 23; 161(3):661-673. PMID: 25910213; PMCID: PMC4409666.
      Citations: 55     Fields:    Translation:HumansCells
    43. Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL, Sharma A, Menche J, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Baribaud F, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Barabási AL, Menche J, Baribaud F, Barab?si AL. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Hum Mol Genet. 2015 Jun 01; 24(11):3005-20. PMID: 25586491; PMCID: PMC4447811.
      Citations: 75     Fields:    Translation:HumansCells
    44. Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M, Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Fontanillo C, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Dricot A, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Menche J, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Trigg SA, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Barabási AL, Iakoucheva LM, Aloy P, De Las Rivas J, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M, Fontanillo C, Dricot A, Menche J, Barab?si AL, Aloy P, De Las Rivas J, Wanamaker SA. A proteome-scale map of the human interactome network. Cell. 2014 11 20; 159(5):1212-1226. PMID: 25416956; PMCID: PMC4266588.
      Citations: 552     Fields:    Translation:HumansAnimals
    45. Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM, Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Dricot A, Zack TI, Sahni N, Jacob Y, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM, Dricot A, Jacob Y. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75. PMID: 25184681; PMCID: PMC4197947.
      Citations: 53     Fields:    Translation:HumansCells
    46. Dittmer TA, Sahni N, Kubben N, Hill DE, Vidal M, Burgess RC, Roukos V, Misteli T, Dittmer TA, Sahni N, Kubben N, Hill DE, Vidal M, Burgess RC, Roukos V, Misteli T. Systematic identification of pathological lamin A interactors. Mol Biol Cell. 2014 May; 25(9):1493-510. PMID: 24623722; PMCID: PMC4004598.
      Citations: 36     Fields:    Translation:HumansCells
    47. Sahni N, Yi S, Zhong Q, Jailkhani N, Charloteaux B, Cusick ME, Vidal M, Sahni N, Yi S, Zhong Q, Jailkhani N, Charloteaux B, Cusick ME, Vidal M. Edgotype: a fundamental link between genotype and phenotype. Curr Opin Genet Dev. 2013 Dec; 23(6):649-57. PMID: 24287335; PMCID: PMC3902775.
      Citations: 64     Fields:    Translation:HumansCells
    48. Phutela UG, Sahni N, Phutela UG, Sahni N. Microscopic Structural Changes in Paddy Straw Pretreated with Trichoderma reesei MTCC 164 and Coriolus versicolor MTCC 138. Indian J Microbiol. 2013 Jun; 53(2):227-31. PMID: 24426113; PMCID: PMC3626948.
      Citations: 1     
    49. Srikantha T, Daniels KJ, Pujol C, Sahni N, Yi S, Soll DR, Srikantha T, Daniels KJ, Pujol C, Sahni N, Yi S, Soll DR. Nonsex genes in the mating type locus of Candida albicans play roles in a/a biofilm formation, including impermeability and fluconazole resistance. PLoS Pathog. 2012 Jan; 8(1):e1002476. PMID: 22253594; PMCID: PMC3257300.
      Citations: 17     Fields:    Translation:Animals
    50. Yi S, Sahni N, Daniels KJ, Lu KL, Srikantha T, Huang G, Garnaas AM, Soll DR, Yi S, Sahni N, Daniels KJ, Lu KL, Srikantha T, Huang G, Garnaas AM, Soll DR. Alternative mating type configurations (a/a versus a/a or a/a) of Candida albicans result in alternative biofilms regulated by different pathways. PLoS Biol. 2011 Aug; 9(8):e1001117. PMID: 21829325; PMCID: PMC3149048.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    51. Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Srikantha T, Soll DR, Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Srikantha T, Soll DR. Self-induction of a/a or alpha/alpha biofilms in Candida albicans is a pheromone-based paracrine system requiring switching. Eukaryot Cell. 2011 Jun; 10(6):753-60. PMID: 21498642; PMCID: PMC3127667.
      Citations: 14     Fields:    Translation:AnimalsCells
    52. Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Garnaas AM, Pujol C, Srikantha T, Soll DR, Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Garnaas AM, Pujol C, Srikantha T, Soll DR. Utilization of the mating scaffold protein in the evolution of a new signal transduction pathway for biofilm development. mBio. 2011 Jan 11; 2(1):e00237-10. PMID: 21221248; PMCID: PMC3018282.
      Citations: 16     Fields:    Translation:AnimalsCells
    53. Sahni N, Yi S, Daniels KJ, Huang G, Srikantha T, Soll DR, Sahni N, Yi S, Daniels KJ, Huang G, Srikantha T, Soll DR. Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways. PLoS Biol. 2010 May 04; 8(5):e1000363. PMID: 20454615; PMCID: PMC2864266.
      Citations: 54     Fields:    Translation:AnimalsCells
    54. Huang G, Yi S, Sahni N, Daniels KJ, Srikantha T, Soll DR, Huang G, Yi S, Sahni N, Daniels KJ, Srikantha T, Soll DR. N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog. 2010 Mar 12; 6(3):e1000806. PMID: 20300604; PMCID: PMC2837409.
      Citations: 117     Fields:    Translation:AnimalsCells
    55. Sahni N, Yi S, Daniels KJ, Srikantha T, Pujol C, Soll DR, Sahni N, Yi S, Daniels KJ, Srikantha T, Pujol C, Soll DR. Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans. PLoS Pathog. 2009 Oct; 5(10):e1000601. PMID: 19798425; PMCID: PMC2745568.
      Citations: 39     Fields:    Translation:AnimalsCells
    56. Huang G, Srikantha T, Sahni N, Yi S, Soll DR, Huang G, Srikantha T, Sahni N, Yi S, Soll DR. CO(2) regulates white-to-opaque switching in Candida albicans. Curr Biol. 2009 Feb 24; 19(4):330-4. PMID: 19200725; PMCID: PMC2667266.
      Citations: 92     Fields:    Translation:Animals
    57. Yi S, Sahni N, Pujol C, Daniels KJ, Srikantha T, Ma N, Soll DR, Yi S, Sahni N, Pujol C, Daniels KJ, Srikantha T, Ma N, Soll DR. A Candida albicans-specific region of the alpha-pheromone receptor plays a selective role in the white cell pheromone response. Mol Microbiol. 2009 Feb; 71(4):925-47. PMID: 19170873.
      Citations: 25     Fields:    Translation:AnimalsCells
    58. Sahni N, Yi S, Pujol C, Soll DR, Sahni N, Yi S, Pujol C, Soll DR. The white cell response to pheromone is a general characteristic of Candida albicans strains. Eukaryot Cell. 2009 Feb; 8(2):251-6. PMID: 19074600; PMCID: PMC2643613.
      Citations: 15     Fields:    Translation:Animals
    59. Srikantha T, Daniels KJ, Wu W, Lockhart SR, Yi S, Sahni N, Ma N, Soll DR, Srikantha T, Daniels KJ, Wu W, Lockhart SR, Yi S, Sahni N, Ma N, Soll DR. Dark brown is the more virulent of the switch phenotypes of Candida glabrata. Microbiology (Reading). 2008 Nov; 154(Pt 11):3309-3318. PMID: 18957584.
      Citations: 10     Fields:    Translation:Animals
    60. Yi S, Sahni N, Daniels KJ, Pujol C, Srikantha T, Soll DR, Yi S, Sahni N, Daniels KJ, Pujol C, Srikantha T, Soll DR. The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans. Mol Biol Cell. 2008 Mar; 19(3):957-70. PMID: 18162580; PMCID: PMC2262975.
      Citations: 44     Fields:    Translation:Animals
    61. An extended set of yeast-based functional assays accurately identifies human disease mutations. Genome Research. 26:670-680.
    62. Multi-OMICs and genome editing perspectives on liver cancer signaling networks. BioMed Research International. 2016.
    63. Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures. Oncotarget. 7:78841-78849.
    64. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science. 351:1450-1454.
    65. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 164:805-817.
    66. Signal Transduction and Regulation. BioMed Research International. 2016.
    67. Global Edgetic Rewiring in Cancer Networks. Cell Systems. 1:251-253.
    68. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Human Molecular Genetics. 24:3005-3020.
    69. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Molecular Systems Biology. 12.
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