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NIDHI SAHNI

TitleAssistant Professor
InstitutionMD Anderson
DepartmentSystems Biology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Osorio D, Capasso A, Eckhardt SG, Giri U, Somma A, Pitts TM, Lieu CH, Messersmith WA, Bagby SM, Singh H, Das J, Sahni N, Yi SS, Kuijjer ML. Population-level comparisons of gene regulatory networks modeled on high-throughput single-cell transcriptomics data. Nat Comput Sci. 2024 Mar; 4(3):237-250. PMID: 38438786; PMCID: PMC10965443.
      Citations: 1     Translation:Humans
    2. Hou J, Wei Y, Zou J, Jaffery R, Sun L, Liang S, Zheng N, Guerrero AM, Egan NA, Bohat R, Chen S, Zheng C, Mao X, Yi SS, Chen K, McGrail DJ, Sahni N, Shi PY, Chen Y, Xie X, Peng W. Integrated multi-omics analyses identify anti-viral host factors and pathways controlling SARS-CoV-2 infection. Nat Commun. 2024 Jan 02; 15(1):109. PMID: 38168026; PMCID: PMC10761986.
      Citations: 2     Fields:    Translation:HumansCells
    3. Li Y, Dobrolecki LE, Sallas C, Zhang X, Kerr TD, Bisht D, Wang Y, Awasthi S, Kaundal B, Wu S, Peng W, Mendillo ML, Lu Y, Jeter CR, Peng G, Liu J, Westin SN, Sood AK, Lewis MT, Das J, Yi SS, Bedford MT, McGrail DJ, Sahni N. PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition. Cell Rep Med. 2023 12 19; 4(12):101326. PMID: 38118413; PMCID: PMC10772459.
      Citations:    Fields:    Translation:HumansCells
    4. McGrail DJ, Li Y, Smith RS, Feng B, Dai H, Hu L, Dennehey B, Awasthi S, Mendillo ML, Sood AK, Mills GB, Lin SY, Yi SS, Sahni N. Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins. Cell Rep Med. 2023 11 21; 4(11):101255. PMID: 37909041; PMCID: PMC10694618.
      Citations:    Fields:    Translation:Humans
    5. Tripathi S, Shirnekhi HK, Gorman SD, Chandra B, Baggett DW, Park CG, Somjee R, Lang B, Hosseini SMH, Pioso BJ, Li Y, Iacobucci I, Gao Q, Edmonson MN, Rice SV, Zhou X, Bollinger J, Mitrea DM, White MR, McGrail DJ, Jarosz DF, Yi SS, Babu MM, Mullighan CG, Zhang J, Sahni N, Kriwacki RW. Defining the condensate landscape of fusion oncoproteins. Nat Commun. 2023 09 28; 14(1):6008. PMID: 37770423; PMCID: PMC10539325.
      Citations: 2     Fields:    Translation:HumansCells
    6. Lacoste J, Haghighi M, Haider S, Lin ZY, Segal D, Reno C, Qian WW, Xiong X, Shafqat-Abbasi H, Ryder PV, Senft R, Cimini BA, Roth FP, Calderwood M, Hill D, Vidal M, Yi SS, Sahni N, Peng J, Gingras AC, Singh S, Carpenter AE, Taipale M. Pervasive mislocalization of pathogenic coding variants underlying human disorders. bioRxiv. 2023 Sep 05. PMID: 37732209; PMCID: PMC10508771.
      Citations:    
    7. Zheng C, Wei Y, Zhang Q, Sun M, Wang Y, Hou J, Zhang P, Lv X, Su D, Jiang Y, Gumin J, Sahni N, Hu B, Wang W, Chen X, McGrail DJ, Zhang C, Huang S, Xu H, Chen J, Lang FF, Hu J, Chen Y. Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. Sci Adv. 2023 08 04; 9(31):eadf3984. PMID: 37540752; PMCID: PMC10403220.
      Citations: 4     Fields:    Translation:HumansCells
    8. Kong Q, Xia S, Pan X, Ye K, Li Z, Li H, Tang X, Sahni N, Yi SS, Liu X, Wu H, Elowitz MB, Lieberman J, Zhang Z. Alternative splicing of GSDMB modulates killer lymphocyte-triggered pyroptosis. Sci Immunol. 2023 04 28; 8(82):eadg3196. PMID: 37115914; PMCID: PMC10338320.
      Citations: 2     Fields:    Translation:HumansCells
    9. Pan X, Coban Akdemir ZH, Gao R, Jiang X, Sheynkman GM, Wu E, Huang JH, Sahni N, Yi SS. AD-Syn-Net: systematic identification of Alzheimer's disease-associated mutation and co-mutation vulnerabilities via deep learning. Brief Bioinform. 2023 03 19; 24(2). PMID: 36752347; PMCID: PMC10025433.
      Citations:    Fields:    Translation:Humans
    10. Pan X, Yun J, Coban Akdemir ZH, Jiang X, Wu E, Huang JH, Sahni N, Yi SS. AI-DrugNet: A network-based deep learning model for drug repurposing and combination therapy in neurological disorders. Comput Struct Biotechnol J. 2023; 21:1533-1542. PMID: 36879885; PMCID: PMC9984442.
      Citations: 1     
    11. Amici DR, Cingoz H, Alasady MJ, Alhayek S, Phoumyvong CM, Sahni N, Yi SS, Mendillo ML. The HAPSTR2 retrogene buffers stress signaling and resilience in mammals. Nat Commun. 2023 01 11; 14(1):152. PMID: 36631436; PMCID: PMC9834230.
      Citations:    Fields:    Translation:AnimalsCells
    12. Hua X, Li Y, Pentaparthi SR, McGrail DJ, Zou R, Guo L, Shrawat A, Cirillo KM, Li Q, Bhat A, Xu M, Qi D, Singh A, McGrath F, Andrews S, Aung KL, Das J, Zhou Y, Lodi A, Mills GB, Eckhardt SG, Mendillo ML, Tiziani S, Wu E, Huang JH, Sahni N, Yi SS. Landscape of MicroRNA Regulatory Network Architecture and Functional Rerouting in Cancer. Cancer Res. 2023 01 04; 83(1):59-73. PMID: 36265133; PMCID: PMC9811166.
      Citations: 1     Fields:    Translation:Humans
    13. Li MM, Awasthi S, Ghosh S, Bisht D, Coban Akdemir ZH, Sheynkman GM, Sahni N, Yi SS. Gain-of-Function Variomics and Multi-omics Network Biology for Precision Medicine. Methods Mol Biol. 2023; 2660:357-372. PMID: 37191809; PMCID: PMC10476052.
      Citations:    Fields:    
    14. Hou J, Liang S, Xu C, Wei Y, Wang Y, Tan Y, Sahni N, McGrail DJ, Bernatchez C, Davies M, Li Y, Chen R, Yi SS, Chen Y, Yee C, Chen K, Peng W. Single-cell CRISPR immune screens reveal immunological roles of tumor intrinsic factors. NAR Cancer. 2022 Dec; 4(4):zcac038. PMID: 36518525; PMCID: PMC9732527.
      Citations:    
    15. Yan G, Luna A, Wang H, Bozorgui B, Li X, Sanchez M, Dereli Z, Kahraman N, Kara G, Chen X, Zheng C, McGrail D, Sahni N, Lu Y, Babur O, Cokol M, Lim B, Ozpolat B, Sander C, Mills GB, Korkut A. BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer. Cell Rep. 2022 09 13; 40(11):111304. PMID: 36103824; PMCID: PMC9523722.
      Citations:    
    16. Chakravarty AK, McGrail DJ, Lozanoski TM, Dunn BS, Shih DJH, Cirillo KM, Cetinkaya SH, Zheng WJ, Mills GB, Yi SS, Jarosz DF, Sahni N. Biomolecular Condensation: A New Phase in Cancer Research. Cancer Discov. 2022 09 02; 12(9):2031-2043. PMID: 35852417; PMCID: PMC9437557.
      Citations:    Fields:    
    17. Pan X, Burgman B, Wu E, Huang JH, Sahni N, Stephen Yi S. i-Modern: Integrated multi-omics network model identifies potential therapeutic targets in glioma by deep learning with interpretability. Comput Struct Biotechnol J. 2022; 20:3511-3521. PMID: 35860408; PMCID: PMC9284388.
      Citations:    
    18. Ningappa M, Rahman SA, Higgs BW, Ashokkumar CS, Sahni N, Sindhi R, Das J. A network-based approach to identify expression modules underlying rejection in pediatric liver transplantation. Cell Rep Med. 2022 04 19; 3(4):100605. PMID: 35492246; PMCID: PMC9044102.
      Citations:    Fields:    Translation:Humans
    19. Li J, Lu H, Ng PK, Pantazi A, Ip CKM, Jeong KJ, Amador B, Tran R, Tsang YH, Yang L, Song X, Dogruluk T, Ren X, Hadjipanayis A, Bristow CA, Lee S, Kucherlapati M, Parfenov M, Tang J, Seth S, Mahadeshwar HS, Mojumdar K, Zeng D, Zhang J, Protopopov A, Seidman JG, Creighton CJ, Lu Y, Sahni N, Shaw KR, Meric-Bernstam F, Futreal A, Chin L, Scott KL, Kucherlapati R, Mills GB, Liang H. A functional genomic approach to actionable gene fusions for precision oncology. Sci Adv. 2022 02 11; 8(6):eabm2382. PMID: 35138907; PMCID: PMC8827659.
      Citations:    Fields:    Translation:Humans
    20. Guo L, Li Y, Cirillo KM, Marick RA, Su Z, Yin X, Hua X, Mills GB, Sahni N, Yi SS. mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity. Brief Bioinform. 2021 09 02; 22(5). PMID: 33855356; PMCID: PMC8579161.
      Citations: 4     Fields:    Translation:HumansCells
    21. Hahn WC, Bader JS, Braun TP, Califano A, Clemons PA, Druker BJ, Ewald AJ, Fu H, Jagu S, Kemp CJ, Kim W, Kuo CJ, McManus M, B Mills G, Mo X, Sahni N, Schreiber SL, Talamas JA, Tamayo P, Tyner JW, Wagner BK, Weiss WA, Gerhard DS, Cancer Target Discovery and Development Network. An expanded universe of cancer targets. Cell. 2021 03 04; 184(5):1142-1155. PMID: 33667368; PMCID: PMC8066437.
      Citations: 23     Fields:    Translation:HumansAnimals
    22. Li Y, Burgman B, Khatri IS, Pentaparthi SR, Su Z, McGrail DJ, Li Y, Wu E, Eckhardt SG, Sahni N, Yi SS. e-MutPath: computational modeling reveals the functional landscape of genetic mutations rewiring interactome networks. Nucleic Acids Res. 2021 01 11; 49(1):e2. PMID: 33211847; PMCID: PMC7797045.
      Citations: 2     Fields:    Translation:HumansCells
    23. Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS. Integrated Genomic Characterization of the Human Immunome in Cancer. Cancer Res. 2020 11 01; 80(21):4854-4867. PMID: 32855206; PMCID: PMC7642109.
      Citations: 4     Fields:    Translation:HumansCells
    24. Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, Lam T, Pilie PG, Zhu H, Beckermann KE, Haake SM, Isgandrova S, Martinez-Moczygemba M, Sahni N, Tannir NM, Lin SY, Rathmell WK, Jonasch E. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020 05 01; 11(1):2135. PMID: 32358509; PMCID: PMC7195420.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    25. Daniels J, Doukas PG, Escala MEM, Ringbloom KG, Shih DJH, Yang J, Tegtmeyer K, Park J, Thomas JJ, Selli ME, Altunbulakli C, Gowthaman R, Mo SH, Jothishankar B, Pease DR, Pro B, Abdulla FR, Shea C, Sahni N, Gru AA, Pierce BG, Louissaint A, Guitart J, Choi J. Cellular origins and genetic landscape of cutaneous gamma delta T cell lymphomas. Nat Commun. 2020 04 14; 11(1):1806. PMID: 32286303; PMCID: PMC7156460.
      Citations: 15     Fields:    Translation:HumansCells
    26. McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY. Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Cancer Cell. 2020 03 16; 37(3):371-386.e12. PMID: 32109374; PMCID: PMC7337255.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    27. Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell. 2019 06 10; 35(6):851-867.e7. PMID: 31185210; PMCID: PMC6642675.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    28. Li Y, McGrail DJ, Xu J, Li J, Liu NN, Sun M, Lin R, Pancsa R, Zhang J, Lee JS, Wang H, Mills GB, Li X, Yi S, Sahni N. MERIT: Systematic Analysis and Characterization of Mutational Effect on RNA Interactome Topology. Hepatology. 2019 08; 70(2):532-546. PMID: 30153342; PMCID: PMC6538468.
      Citations: 18     Fields:    Translation:Humans
    29. Lu J, Xu J, Li J, Pan T, Bai J, Wang L, Jin X, Lin X, Zhang Y, Li Y, Sahni N, Li X. FACER: comprehensive molecular and functional characterization of epigenetic chromatin regulators. Nucleic Acids Res. 2018 11 02; 46(19):10019-10033. PMID: 30102398; PMCID: PMC6212842.
      Citations: 4     Fields:    Translation:HumansCells
    30. Ip CKM, Ng PKS, Jeong KJ, Shao SH, Ju Z, Leonard PG, Hua X, Vellano CP, Woessner R, Sahni N, Scott KL, Mills GB. Neomorphic PDGFRA extracellular domain driver mutations are resistant to PDGFRA targeted therapies. Nat Commun. 2018 11 02; 9(1):4583. PMID: 30389923; PMCID: PMC6214970.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    31. Li Y, McGrail DJ, Xu J, Mills GB, Sahni N, Yi S. Gene Regulatory Network Perturbation by Genetic and Epigenetic Variation. Trends Biochem Sci. 2018 08; 43(8):576-592. PMID: 29941230; PMCID: PMC6215597.
      Citations: 8     Fields:    Translation:HumansCells
    32. Li Y, McGrail DJ, Latysheva N, Yi S, Babu MM, Sahni N. Pathway perturbations in signaling networks: Linking genotype to phenotype. Semin Cell Dev Biol. 2020 03; 99:3-11. PMID: 29738884; PMCID: PMC6230320.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    33. McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N. Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. Nat Commun. 2018 04 03; 9(1):1317. PMID: 29615613; PMCID: PMC5882811.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    34. Ng PK, Li J, Jeong KJ, Shao S, Chen H, Tsang YH, Sengupta S, Wang Z, Bhavana VH, Tran R, Soewito S, Minussi DC, Moreno D, Kong K, Dogruluk T, Lu H, Tokheim C, Zhou DC, Johnson AM, Zeng J, Ip CKM, Ju Z, Wester M, Yu S, Li Y, Vellano CP, Karchin R, Ding L, Lu Y, Cheung LWT, Chen K, Shaw KR, Meric-Bernstam F, Scott KL, Yi S, Sahni N, Liang H, Mills GB, Gao J, Schultz N. Systematic Functional Annotation of Somatic Mutations in Cancer. Cancer Cell. 2018 03 12; 33(3):450-462.e10. PMID: 29533785; PMCID: PMC5926201.
      Citations: 78     Fields:    Translation:Humans
    35. Li Y, Li L, Wang Z, Pan T, Sahni N, Jin X, Wang G, Li J, Zheng X, Zhang Y, Xu J, Yi S, Li X. LncMAP: Pan-cancer atlas of long noncoding RNA-mediated transcriptional network perturbations. Nucleic Acids Res. 2018 02 16; 46(3):1113-1123. PMID: 29325141; PMCID: PMC5815097.
      Citations: 49     Fields:    Translation:HumansCells
    36. Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S. Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer. Cell Rep. 2017 Oct 17; 21(3):798-812. PMID: 29045845; PMCID: PMC5689467.
      Citations: 23     Fields:    Translation:HumansCells
    37. Yi S, Liu NN, Hu L, Wang H, Sahni N. Base-resolution stratification of cancer mutations using functional variomics. Nat Protoc. 2017 Nov; 12(11):2323-2341. PMID: 28981122; PMCID: PMC6145840.
      Citations: 3     Fields:    Translation:HumansCells
    38. Yi S, Sahni N. Regulome networks and mutational landscape in liver cancer: An informative path to precision medicine. Hepatology. 2017 07; 66(1):280-282. PMID: 28422313; PMCID: PMC6129387.
      Citations:    Fields:    Translation:Humans
    39. Yi S, Lin S, Li Y, Zhao W, Mills GB, Sahni N. Functional variomics and network perturbation: connecting genotype to phenotype in cancer. Nat Rev Genet. 2017 07; 18(7):395-410. PMID: 28344341; PMCID: PMC6020840.
      Citations: 40     Fields:    Translation:Humans
    40. Karras GI, Yi S, Sahni N, Xie J, Vidal M, D'Andrea AD, Whitesell L, Lindquist S, Fischer M. HSP90 Shapes the Consequences of Human Genetic Variation. Cell. 2017 Feb 23; 168(5):856-866.e12. PMID: 28215707; PMCID: PMC5325763.
      Citations: 43     Fields:    Translation:HumansCells
    41. Chung CY, Khurana V, Yi S, Sahni N, Loh KH, Auluck PK, Baru V, Udeshi ND, Freyzon Y, Carr SA, Hill DE, Vidal M, Ting AY, Lindquist S. In Situ Peroxidase Labeling and Mass-Spectrometry Connects Alpha-Synuclein Directly to Endocytic Trafficking and mRNA Metabolism in Neurons. Cell Syst. 2017 02 22; 4(2):242-250.e4. PMID: 28131823; PMCID: PMC5578869.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    42. Li Y, Sahni N, Yi S. Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures. Oncotarget. 2016 Nov 29; 7(48):78841-78849. PMID: 27791983; PMCID: PMC5346681.
      Citations: 7     Fields:    Translation:HumansCells
    43. Yi S, Chen S, Zhang L, Sahni N. Signal Transduction and Regulation: Insights into Evolution. Biomed Res Int. 2016; 2016:8604245. PMID: 27525280; PMCID: PMC4971294.
      Citations:    Fields:    Translation:HumansAnimalsCells
    44. Lin S, Yin YA, Jiang X, Sahni N, Yi S. Multi-OMICs and Genome Editing Perspectives on Liver Cancer Signaling Networks. Biomed Res Int. 2016; 2016:6186281. PMID: 27403431; PMCID: PMC4923561.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    45. Yachie N, Petsalaki E, Mellor JC, Weile J, Verby M, Ozturk SB, Li S, Cote AG, Mosca R, Knapp JJ, Ko M, Yu A, Gebbia M, Sahni N, Yi S, Tyagi T, Sheykhkarimli D, Roth JF, Wong C, Musa L, Snider J, Liu YC, Yu H, Stagljar I, Hao T, Calderwood MA, Pelletier L, Hill DE, Vidal M, Roth FP, Jacob Y, Braun P, Aloy P. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Mol Syst Biol. 2016 Apr 22; 12(4):863. PMID: 27107012; PMCID: PMC4848762.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    46. Barrera LA, Vedenko A, Kurland JV, Rogers JM, Gisselbrecht SS, Rossin EJ, Woodard J, Mariani L, Kock KH, Inukai S, Siggers T, Shokri L, Sahni N, Cotsapas C, Hao T, Yi S, Kellis M, Daly MJ, Vidal M, Hill DE, Bulyk ML, Gord?n R. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science. 2016 Mar 25; 351(6280):1450-1454. PMID: 27013732; PMCID: PMC4825693.
      Citations: 61     Fields:    Translation:HumansCells
    47. Sun S, Yang F, Tan G, Costanzo M, Oughtred R, Hirschman J, Theesfeld CL, Bansal P, Sahni N, Yi S, Yu A, Tyagi T, Tie C, Hill DE, Vidal M, Andrews BJ, Boone C, Dolinski K, Roth FP. An extended set of yeast-based functional assays accurately identifies human disease mutations. Genome Res. 2016 05; 26(5):670-80. PMID: 26975778; PMCID: PMC4864455.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    48. Yang X, Coulombe-Huntington J, Kang S, Sheynkman GM, Hao T, Richardson A, Yang F, Shen YA, Murray RR, Spirohn K, Begg BE, Duran-Frigola M, MacWilliams A, Pevzner SJ, Zhong Q, Tam S, Ghamsari L, Sahni N, Yi S, Rodriguez MD, Balcha D, Tan G, Costanzo M, Andrews B, Boone C, Zhou XJ, Salehi-Ashtiani K, Charloteaux B, Chen AA, Calderwood MA, Roth FP, Hill DE, Iakoucheva LM, Xia Y, Vidal M, Sun S, Aloy P, Wanamaker SA. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 2016 02 11; 164(4):805-17. PMID: 26871637; PMCID: PMC4882190.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    49. Wang Y, Sahni N, Vidal M. Global Edgetic Rewiring in Cancer Networks. Cell Syst. 2015 Oct 28; 1(4):251-3. PMID: 27136053.
      Citations: 5     Fields:    
    50. Taipale M, Fuxman Bass JI, Coulombe-Huntington J, Peng J, Karras GI, Kamburov A, Krykbaeva I, Lam MH, Tucker G, Khurana V, Liu YY, Zhong Q, Palagi A, San-Miguel A, Jordan DM, Walsh JM, Shah AA, Yang X, Stoyanova AK, Leighton A, Salehi-Ashtiani K, Whitesell LJ, Sunyaev S, Xia Y, Walhout AJM, Lindquist S, Sahni N, Yi S, Yang F, Weile J, Wang Y, Kov?cs IA, Sharma A, Yachie N, Shen Y, Fan C, Balcha D, Dricot A, Calderwood MA, Jacob Y, Cusick ME, Berger B, Barab?si AL, Charloteaux B, Hill DE, Hao T, Roth FP, Vidal M. Widespread macromolecular interaction perturbations in human genetic disorders. Cell. 2015 Apr 23; 161(3):647-660. PMID: 25910212; PMCID: PMC4441215.
      Citations: 206     Fields:    Translation:HumansCells
    51. Fuxman Bass JI, Sahni N, Shrestha S, Garcia-Gonzalez A, Mori A, Bhat N, Yi S, Hill DE, Vidal M, Walhout AJM. Human gene-centered transcription factor networks for enhancers and disease variants. Cell. 2015 Apr 23; 161(3):661-673. PMID: 25910213; PMCID: PMC4409666.
      Citations: 55     Fields:    Translation:HumansCells
    52. Sharma A, Huang CC, Ort T, Zhou X, Kitsak M, Sahni N, Thibault D, Voung L, Guo F, Ghiassian SD, Gulbahce N, Tocker J, Dobrin R, Barnathan E, Liu H, Panettieri RA, Tantisira KG, Qiu W, Raby BA, Silverman EK, Vidal M, Weiss ST, Menche J, Baribaud F, Barab?si AL. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Hum Mol Genet. 2015 Jun 01; 24(11):3005-20. PMID: 25586491; PMCID: PMC4447811.
      Citations: 75     Fields:    Translation:HumansCells
    53. Rolland T, Tasan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, Yi S, Lemmens I, Mosca R, Kamburov A, Ghiassian SD, Yang X, Ghamsari L, Balcha D, Begg BE, Braun P, Brehme M, Broly MP, Carvunis AR, Convery-Zupan D, Corominas R, Coulombe-Huntington J, Dann E, Dreze M, Fan C, Franzosa E, Gebreab F, Gutierrez BJ, Hardy MF, Jin M, Kang S, Kiros R, Lin GN, Luck K, MacWilliams A, Murray RR, Palagi A, Poulin MM, Rambout X, Rasla J, Reichert P, Romero V, Ruyssinck E, Sahalie JM, Scholz A, Shah AA, Sharma A, Shen Y, Spirohn K, Tam S, Tejeda AO, Twizere JC, Vega K, Walsh J, Cusick ME, Xia Y, Iakoucheva LM, Tavernier J, Calderwood MA, Hill DE, Hao T, Roth FP, Vidal M, Fontanillo C, Dricot A, Menche J, Barab?si AL, Aloy P, De Las Rivas J, Wanamaker SA. A proteome-scale map of the human interactome network. Cell. 2014 11 20; 159(5):1212-1226. PMID: 25416956; PMCID: PMC4266588.
      Citations: 552     Fields:    Translation:HumansAnimals
    54. Hill SJ, Rolland T, Adelmant G, Xia X, Owen MS, Zack TI, Sahni N, Hao T, McKinney KM, Clark AP, Reyon D, Tsai SQ, Joung JK, Beroukhim R, Marto JA, Vidal M, Gaudet S, Hill DE, Livingston DM, Dricot A, Jacob Y. Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damage. Genes Dev. 2014 Sep 01; 28(17):1957-75. PMID: 25184681; PMCID: PMC4197947.
      Citations: 53     Fields:    Translation:HumansCells
    55. Dittmer TA, Sahni N, Kubben N, Hill DE, Vidal M, Burgess RC, Roukos V, Misteli T. Systematic identification of pathological lamin A interactors. Mol Biol Cell. 2014 May; 25(9):1493-510. PMID: 24623722; PMCID: PMC4004598.
      Citations: 36     Fields:    Translation:HumansCells
    56. Sahni N, Yi S, Zhong Q, Jailkhani N, Charloteaux B, Cusick ME, Vidal M. Edgotype: a fundamental link between genotype and phenotype. Curr Opin Genet Dev. 2013 Dec; 23(6):649-57. PMID: 24287335; PMCID: PMC3902775.
      Citations: 64     Fields:    Translation:HumansCells
    57. Phutela UG, Sahni N. Microscopic Structural Changes in Paddy Straw Pretreated with Trichoderma reesei MTCC 164 and Coriolus versicolor MTCC 138. Indian J Microbiol. 2013 Jun; 53(2):227-31. PMID: 24426113; PMCID: PMC3626948.
      Citations: 1     
    58. Srikantha T, Daniels KJ, Pujol C, Sahni N, Yi S, Soll DR. Nonsex genes in the mating type locus of Candida albicans play roles in a/a biofilm formation, including impermeability and fluconazole resistance. PLoS Pathog. 2012 Jan; 8(1):e1002476. PMID: 22253594; PMCID: PMC3257300.
      Citations: 17     Fields:    Translation:Animals
    59. Yi S, Sahni N, Daniels KJ, Lu KL, Srikantha T, Huang G, Garnaas AM, Soll DR. Alternative mating type configurations (a/a versus a/a or a/a) of Candida albicans result in alternative biofilms regulated by different pathways. PLoS Biol. 2011 Aug; 9(8):e1001117. PMID: 21829325; PMCID: PMC3149048.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    60. Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Srikantha T, Soll DR. Self-induction of a/a or alpha/alpha biofilms in Candida albicans is a pheromone-based paracrine system requiring switching. Eukaryot Cell. 2011 Jun; 10(6):753-60. PMID: 21498642; PMCID: PMC3127667.
      Citations: 14     Fields:    Translation:AnimalsCells
    61. Yi S, Sahni N, Daniels KJ, Lu KL, Huang G, Garnaas AM, Pujol C, Srikantha T, Soll DR. Utilization of the mating scaffold protein in the evolution of a new signal transduction pathway for biofilm development. mBio. 2011 Jan 11; 2(1):e00237-10. PMID: 21221248; PMCID: PMC3018282.
      Citations: 16     Fields:    Translation:AnimalsCells
    62. Sahni N, Yi S, Daniels KJ, Huang G, Srikantha T, Soll DR. Tec1 mediates the pheromone response of the white phenotype of Candida albicans: insights into the evolution of new signal transduction pathways. PLoS Biol. 2010 May 04; 8(5):e1000363. PMID: 20454615; PMCID: PMC2864266.
      Citations: 54     Fields:    Translation:AnimalsCells
    63. Huang G, Yi S, Sahni N, Daniels KJ, Srikantha T, Soll DR. N-acetylglucosamine induces white to opaque switching, a mating prerequisite in Candida albicans. PLoS Pathog. 2010 Mar 12; 6(3):e1000806. PMID: 20300604; PMCID: PMC2837409.
      Citations: 117     Fields:    Translation:AnimalsCells
    64. Sahni N, Yi S, Daniels KJ, Srikantha T, Pujol C, Soll DR. Genes selectively up-regulated by pheromone in white cells are involved in biofilm formation in Candida albicans. PLoS Pathog. 2009 Oct; 5(10):e1000601. PMID: 19798425; PMCID: PMC2745568.
      Citations: 39     Fields:    Translation:AnimalsCells
    65. Huang G, Srikantha T, Sahni N, Yi S, Soll DR. CO(2) regulates white-to-opaque switching in Candida albicans. Curr Biol. 2009 Feb 24; 19(4):330-4. PMID: 19200725; PMCID: PMC2667266.
      Citations: 92     Fields:    Translation:Animals
    66. Yi S, Sahni N, Pujol C, Daniels KJ, Srikantha T, Ma N, Soll DR. A Candida albicans-specific region of the alpha-pheromone receptor plays a selective role in the white cell pheromone response. Mol Microbiol. 2009 Feb; 71(4):925-47. PMID: 19170873.
      Citations: 25     Fields:    Translation:AnimalsCells
    67. Sahni N, Yi S, Pujol C, Soll DR. The white cell response to pheromone is a general characteristic of Candida albicans strains. Eukaryot Cell. 2009 Feb; 8(2):251-6. PMID: 19074600; PMCID: PMC2643613.
      Citations: 15     Fields:    Translation:Animals
    68. Srikantha T, Daniels KJ, Wu W, Lockhart SR, Yi S, Sahni N, Ma N, Soll DR. Dark brown is the more virulent of the switch phenotypes of Candida glabrata. Microbiology (Reading). 2008 Nov; 154(Pt 11):3309-3318. PMID: 18957584.
      Citations: 10     Fields:    Translation:Animals
    69. Yi S, Sahni N, Daniels KJ, Pujol C, Srikantha T, Soll DR. The same receptor, G protein, and mitogen-activated protein kinase pathway activate different downstream regulators in the alternative white and opaque pheromone responses of Candida albicans. Mol Biol Cell. 2008 Mar; 19(3):957-70. PMID: 18162580; PMCID: PMC2262975.
      Citations: 44     Fields:    Translation:Animals
    70. An extended set of yeast-based functional assays accurately identifies human disease mutations. Genome Research. 26:670-680.
    71. Multi-OMICs and genome editing perspectives on liver cancer signaling networks. BioMed Research International. 2016.
    72. Comparative analysis of protein interactome networks prioritizes candidate genes with cancer signatures. Oncotarget. 7:78841-78849.
    73. Survey of variation in human transcription factors reveals prevalent DNA binding changes. Science. 351:1450-1454.
    74. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. Cell. 164:805-817.
    75. Signal Transduction and Regulation. BioMed Research International. 2016.
    76. Global Edgetic Rewiring in Cancer Networks. Cell Systems. 1:251-253.
    77. A disease module in the interactome explains disease heterogeneity, drug response and captures novel pathways and genes in asthma. Human Molecular Genetics. 24:3005-3020.
    78. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Molecular Systems Biology. 12.
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