TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentHuffington Center on Aging
    DivisionHuffington Ctr on Aging

    Collapse Research 
    Collapse research activities and funding
    R01AI074809     (CAO, WEI)Aug 1, 2007 - Jul 31, 2013
    Receptors Of Plasmacytoid Dendritic Cells And Their Ligands
    Role: PI

    R01AG057587     (CAO, WEI)Jun 1, 2018 - Feb 28, 2023
    Interrogating the Interferon Pathway in Aging and Alzheimer's Disease
    Role: Principal Investigator

    A20183775     (Wei Cao)Jul 1, 2018 - Jun 30, 2021
    Bright Focus Foundation
    Role of type I interferon in Alzheimer's Disease

    59723     (Wei Cao)Dec 11, 2019 - Dec 20, 2020
    Brown Foundation
    Targeting Interferon-mediated Neuroinflammation to Restore Age-related Memory Deficits

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Roy ER and Cao W. Antiviral Immune Response in Alzheimer’s Disease: Connecting the Dots. Front Neurosci. 2020; https://www.frontiersin.org/ar. View Publication.
    2. Roy ER, Wang B, Wan YW, Chiu G, Cole A, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, Cao W. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. J Clin Invest. 2020 04 01; 130(4):1912-1930. PMID: 31917687.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    3. Cao W, Zheng H. Peripheral immune system in aging and Alzheimer's disease. Mol Neurodegener. 2018 10 03; 13(1):51. PMID: 30285785.
      Citations: 41     Fields:    Translation:HumansAnimals
    4. Sindhava VJ, Oropallo MA, Moody K, Naradikian M, Higdon LE, Zhou L, Myles A, Green N, Nündel K, Stohl W, Schmidt AM, Cao W, Dorta-Estremera S, Kambayashi T, Marshak-Rothstein A, Cancro MP. A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigens. J Clin Invest. 2017 May 01; 127(5):1651-1663. PMID: 28346226.
      Citations: 23     Fields:    Translation:AnimalsCells
    5. Huang X, Dorta-Estremera S, Yao Y, Shen N, Cao W. Predominant Role of Plasmacytoid Dendritic Cells in Stimulating Systemic Autoimmunity. Front Immunol. 2015; 6:526. PMID: 26528288.
      Citations: 9     Fields:    
    6. Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-? Production via the Generation of Reactive Oxygen Species. Cell Rep. 2015 Aug 18; 12(7):1120-32. PMID: 26257170.
      Citations: 19     Fields:    Translation:AnimalsCells
    7. Dorta-Estremera SM, Cao W. Human Pentraxins Bind to Misfolded Proteins and Inhibit Production of Type I Interferon Induced by Nucleic Acid-Containing Amyloid. J Clin Cell Immunol. 2015; 6:332. View Publication.
    8. Yu J, Zhou X, Chang M, Nakaya M, Chang JH, Xiao Y, Lindsey JW, Dorta-Estremera S, Cao W, Zal A, Zal T, Sun SC. Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation. Nat Commun. 2015 Jan 21; 6:6074. PMID: 25606824.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    9. Cao W. Pivotal Functions of Plasmacytoid Dendritic Cells in Systemic Autoimmune Pathogenesis. J Clin Cell Immunol. 2014 Apr 22; 5(2):212. PMID: 25077037.
      Citations: 7     
    10. Dorta-Estremera SM, Li J, Cao W. Rapid generation of amyloid from native proteins in vitro. J Vis Exp. 2013 Dec 05; (82):50869. PMID: 24335677.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    11. Di Domizio J, Dorta-Estremera S, Cao W. Methylated BSA mimics amyloid-related proteins and triggers inflammation. PLoS One. 2013; 8(5):e63214. PMID: 23650555.
      Citations: 1     Fields:    Translation:AnimalsCells
    12. Di Domizio J, Cao W. Fueling autoimmunity: type I interferon in autoimmune diseases. Expert Rev Clin Immunol. 2013 Mar; 9(3):201-10. PMID: 23445195.
      Citations: 23     Fields:    Translation:HumansCells
    13. Di Domizio J, Dorta-Estremera S, Gagea M, Ganguly D, Meller S, Li P, Zhao B, Tan FK, Bi L, Gilliet M, Cao W. Nucleic acid-containing amyloid fibrils potently induce type I interferon and stimulate systemic autoimmunity. Proc Natl Acad Sci U S A. 2012 Sep 04; 109(36):14550-5. PMID: 22904191.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    14. Bao M, Hanabuchi S, Facchinetti V, Du Q, Bover L, Plumas J, Chaperot L, Cao W, Qin J, Sun SC, Liu YJ. CD2AP/SHIP1 complex positively regulates plasmacytoid dendritic cell receptor signaling by inhibiting the E3 ubiquitin ligase Cbl. J Immunol. 2012 Jul 15; 189(2):786-92. PMID: 22706086.
      Citations: 23     Fields:    Translation:HumansCells
    15. Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant. 2012 Aug; 18(8):1174-81. PMID: 22664751.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Esashi E, Bao M, Wang YH, Cao W, Liu YJ. PACSIN1 regulates the TLR7/9-mediated type I interferon response in plasmacytoid dendritic cells. Eur J Immunol. 2012 Mar; 42(3):573-9. PMID: 22488361.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    17. Di Domizio J, Zhang R, Stagg LJ, Gagea M, Zhuo M, Ladbury JE, Cao W. Binding with nucleic acids or glycosaminoglycans converts soluble protein oligomers to amyloid. J Biol Chem. 2012 Jan 02; 287(1):736-747. PMID: 22102410.
      Citations: 29     Fields:    Translation:HumansCells
    18. Cao W, Bover L. Signaling and ligand interaction of ILT7: receptor-mediated regulatory mechanisms for plasmacytoid dendritic cells. Immunol Rev. 2010 Mar; 234(1):163-76. PMID: 20193018.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    19. Hanabuchi S, Ito T, Park WR, Watanabe N, Shaw JL, Roman E, Arima K, Wang YH, Voo KS, Cao W, Liu YJ. Thymic stromal lymphopoietin-activated plasmacytoid dendritic cells induce the generation of FOXP3+ regulatory T cells in human thymus. J Immunol. 2010 Mar 15; 184(6):2999-3007. PMID: 20173030.
      Citations: 76     Fields:    Translation:HumansCells
    20. Cao W, Bover L, Cho M, Wen X, Hanabuchi S, Bao M, Rosen DB, Wang YH, Shaw JL, Du Q, Li C, Arai N, Yao Z, Lanier LL, Liu YJ. Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction. J Exp Med. 2009 Jul 06; 206(7):1603-14. PMID: 19564354.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    21. Cao W. Molecular characterization of human plasmacytoid dendritic cells. J Clin Immunol. 2009 May; 29(3):257-64. PMID: 19266271.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    22. Gilliet M, Cao W, Liu YJ. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat Rev Immunol. 2008 Aug; 8(8):594-606. PMID: 18641647.
      Citations: 437     Fields:    Translation:HumansCells
    23. Rosen DB, Cao W, Avery DT, Tangye SG, Liu YJ, Houchins JP, Lanier LL. Functional consequences of interactions between human NKR-P1A and its ligand LLT1 expressed on activated dendritic cells and B cells. J Immunol. 2008 May 15; 180(10):6508-17. PMID: 18453569.
      Citations: 63     Fields:    Translation:HumansCells
    24. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, Cao W, Wang YH, Su B, Nestle FO, Zal T, Mellman I, Schröder JM, Liu YJ, Gilliet M. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007 Oct 04; 449(7162):564-9. PMID: 17873860.
      Citations: 571     Fields:    Translation:HumansCells
    25. Cao W, Zhang L, Rosen DB, Bover L, Watanabe G, Bao M, Lanier LL, Liu YJ. BDCA2/Fc epsilon RI gamma complex signals through a novel BCR-like pathway in human plasmacytoid dendritic cells. PLoS Biol. 2007 Sep 11; 5(10):e248. PMID: 17850179.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    26. Cao W, Liu YJ. Innate immune functions of plasmacytoid dendritic cells. Curr Opin Immunol. 2007 Feb; 19(1):24-30. PMID: 17113765.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    27. Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ. Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med. 2006 Jun 12; 203(6):1399-405. PMID: 16735691.
      Citations: 108     Fields:    Translation:HumansCells
    28. Cao W, Liu YJ. Opn: key regulator of pDC interferon production. Nat Immunol. 2006 May; 7(5):441-3. PMID: 16622428.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    29. Hanabuchi S, Watanabe N, Wang YH, Wang YH, Ito T, Shaw J, Cao W, Qin FX, Liu YJ. Human plasmacytoid predendritic cells activate NK cells through glucocorticoid-induced tumor necrosis factor receptor-ligand (GITRL). Blood. 2006 May 01; 107(9):3617-23. PMID: 16397134.
      Citations: 48     Fields:    Translation:HumansCells
    30. Ito T, Kanzler H, Duramad O, Cao W, Liu YJ. Specialization, kinetics, and repertoire of type 1 interferon responses by human plasmacytoid predendritic cells. Blood. 2006 Mar 15; 107(6):2423-31. PMID: 16293610.
      Citations: 105     Fields:    Translation:HumansCells
    31. Ito T, Wang YH, Duramad O, Hori T, Delespesse GJ, Watanabe N, Qin FX, Yao Z, Cao W, Liu YJ. TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand. J Exp Med. 2005 Nov 07; 202(9):1213-23. PMID: 16275760.
      Citations: 385     Fields:    Translation:HumansCells
    32. Watanabe N, Wang YH, Lee HK, Ito T, Wang YH, Cao W, Liu YJ. Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus. Nature. 2005 Aug 25; 436(7054):1181-5. PMID: 16121185.
      Citations: 212     Fields:    Translation:HumansCells
    33. Smelt SC, Borrow P, Kunz S, Cao W, Tishon A, Lewicki H, Campbell KP, Oldstone MB. Differences in affinity of binding of lymphocytic choriomeningitis virus strains to the cellular receptor alpha-dystroglycan correlate with viral tropism and disease kinetics. J Virol. 2001 Jan; 75(1):448-57. PMID: 11119613.
      Citations: 60     Fields:    Translation:AnimalsCells
    34. Cao W, Henry MD, Borrow P, Yamada H, Elder JH, Ravkov EV, Nichol ST, Compans RW, Campbell KP, Oldstone MB. Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus. Science. 1998 Dec 11; 282(5396):2079-81. PMID: 9851928.
      Citations: 280     Fields:    Translation:AnimalsCells
    35. Cao W, Oldstone MB, De La Torre JC. Viral persistent infection affects both transcriptional and posttranscriptional regulation of neuron-specific molecule GAP43. Virology. 1997 Apr 14; 230(2):147-54. PMID: 9143270.
      Citations: 3     Fields:    Translation:AnimalsCells
    36. Cao W, Douglas MG. Specific targeting of ISP6 to mitochondria is mediated by sequences other than its amino terminus. Biochem Biophys Res Commun. 1996 Jul 16; 224(2):457-61. PMID: 8702410.
      Citations: 2     Fields:    Translation:AnimalsCells
    37. Cao W, Douglas MG. Biogenesis of ISP6, a small carboxyl-terminal anchored protein of the receptor complex of the mitochondrial outer membrane. J Biol Chem. 1995 Mar 10; 270(10):5674-9. PMID: 7890690.
      Citations: 11     Fields:    Translation:AnimalsCells
    38. Kassenbrock CK, Cao W, Douglas MG. Genetic and biochemical characterization of ISP6, a small mitochondrial outer membrane protein associated with the protein translocation complex. EMBO J. 1993 Aug; 12(8):3023-34. PMID: 8344244.
      Citations: 32     Fields:    Translation:AnimalsCells
    39. Ke H, Mayrose D, Cao W. Crystal structure of cyclophilin A complexed with substrate Ala-Pro suggests a solvent-assisted mechanism of cis-trans isomerization. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3324-8. PMID: 8475075.
      Citations: 15     Fields:    Translation:Cells
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