PANKAJ KUMAR SINGH

TitleInstructor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang X, Li Y, Li Z, Lin S, Wang H, Sun J, Lan C, Wu L, Sun D, Huang C, Singh PK, Hempel N, Trebak M, DeNicola GM, Hao J, Yang S. Mitochondrial Calcium Uniporter Drives Metastasis and Confers a Targetable Cystine Dependency in Pancreatic Cancer. Cancer Res. 2022 Jun 15; 82(12):2254-2268. PMID: 35413105.
      Citations:    Fields:    Translation:HumansCells
    2. Gupta K, Jones JC, Farias VA, Mackeyev Y, Singh PK, Quiñones-Hinojosa A, Krishnan S. Identification of Synergistic Drug Combinations to Target KRAS-Driven Chemoradioresistant Cancers Utilizing Tumoroid Models of Colorectal Adenocarcinoma and Recurrent Glioblastoma. Front Oncol. 2022; 12:840241. PMID: 35664781.
      Citations:    
    3. Shukla S, Fletcher S, Chauhan J, Chalfant V, Riveros C, Mackeyev Y, Singh PK, Krishnan S, Osumi T, Balaji KC. 3JC48-3 (methyl 4'-methyl-5-(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)-[1,1'-biphenyl]-3-carboxylate): a novel MYC/MAX dimerization inhibitor reduces prostate cancer growth. Cancer Gene Ther. 2022 Apr 19. PMID: 35440696.
      Citations:    Fields:    
    4. Powell RT, Moussalli MJ, Guo L, Bae G, Singh P, Stephan C, Shureiqi I, Davies PJ. deepOrganoid: A brightfield cell viability model for screening matrix-embedded organoids. SLAS Discov. 2022 04; 27(3):175-184. PMID: 35314378.
      Citations:    Fields:    Translation:Humans
    5. Stossi F, Singh PK, Mistry RM, Johnson HL, Dandekar RD, Mancini MG, Szafran AT, Rao AU, Mancini MA. Quality Control for Single Cell Imaging Analytics Using Endocrine Disruptor-Induced Changes in Estrogen Receptor Expression. Environ Health Perspect. 2022 02; 130(2):27008. PMID: 35167326.
      Citations:    Fields:    
    6. Xu PC, You M, Yu SY, Luan Y, Eldani M, Caffrey TC, Grandgenett PM, O'Connell KA, Shukla SK, Kattamuri C, Hollingsworth MA, Singh PK, Thompson TB, Chung S, Kim SY. Visceral adipose tissue remodeling in pancreatic ductal adenocarcinoma cachexia: the role of activin A signaling. Sci Rep. 2022 01 31; 12(1):1659. PMID: 35102236.
      Citations:    Fields:    Translation:HumansAnimalsCells
    7. Bhattarai S, Mackeyev Y, Venkatesulu BP, Krishnan S, Singh PK. CXC chemokine receptor 4 (CXCR4) targeted gold nanoparticles potently enhance radiotherapy outcomes in breast cancer. Nanoscale. 2021 Nov 25; 13(45):19056-19065. PMID: 34757363.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Markov SD, Caffrey TC, O'Connell KA, Grunkemeyer JA, Shin S, Hanson R, Patil PP, Shukla SK, Gonzalez D, Crawford AJ, Vance KE, Huang Y, Eberle KC, Radhakrishnan P, Grandgenett PM, Singh PK, Madiyalakan R, Daniels-Wells TR, Penichet ML, Nicodemus CF, Poole JA, Jaffee EM, Hollingsworth MA, Mehla K. IgE-Based Therapeutic Combination Enhances Antitumor Response in Preclinical Models of Pancreatic Cancer. Mol Cancer Ther. 2021 12; 20(12):2457-2468. PMID: 34625505.
      Citations:    Fields:    Translation:HumansAnimals
    9. Bolt MJ, Singh P, Obkirchner CE, Powell RT, Mancini MG, Szafran AT, Stossi F, Mancini MA. Endocrine disrupting chemicals differentially alter intranuclear dynamics and transcriptional activation of estrogen receptor-a. iScience. 2021 Nov 19; 24(11):103227. PMID: 34712924.
      Citations:    
    10. Schultz CW, McCarthy GA, Nerwal T, Nevler A, DuHadaway JB, McCoy MD, Jiang W, Brown SZ, Goetz A, Jain A, Calvert VS, Vishwakarma V, Wang D, Preet R, Cassel J, Summer R, Shaghaghi H, Pommier Y, Baechler SA, Pishvaian MJ, Golan T, Yeo CJ, Petricoin EF, Prendergast GC, Salvino J, Singh PK, Dixon DA, Brody JR. The FDA-Approved Anthelmintic Pyrvinium Pamoate Inhibits Pancreatic Cancer Cells in Nutrient-Depleted Conditions by Targeting the Mitochondria. Mol Cancer Ther. 2021 11; 20(11):2166-2176. PMID: 34413127.
      Citations:    Fields:    Translation:HumansAnimals
    11. Dragojevic S, Ji J, Singh PK, Connors MA, Mutter RW, Lester SC, Talele SM, Zhang W, Carlson BL, Remmes NB, Park SS, Elmquist WF, Krishnan S, Tryggestad EJ, Sarkaria JN. Preclinical Risk Evaluation of Normal Tissue Injury With Novel Radiosensitizers. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):e54-e62. PMID: 34400266.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Lee JH, Wang R, Xiong F, Krakowiak J, Liao Z, Nguyen PT, Moroz-Omori EV, Shao J, Zhu X, Bolt MJ, Wu H, Singh PK, Bi M, Shi CJ, Jamal N, Li G, Mistry R, Jung SY, Tsai KL, Ferreon JC, Stossi F, Caflisch A, Liu Z, Mancini MA, Li W. Enhancer RNA m6A methylation facilitates transcriptional condensate formation and gene activation. Mol Cell. 2021 08 19; 81(16):3368-3385.e9. PMID: 34375583.
      Citations: 11     Fields:    Translation:HumansCells
    13. Ye R, Qiao Y, Singh PK, Wang Y, He J, Li N, Krishnan S, Lin SH. High-Content Clonogenic Survival Screen to Identify Chemoradiation Sensitizers. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):e27-e37. PMID: 34348174.
      Citations:    Fields:    Translation:Humans
    14. Lin S, Li Y, Wang D, Huang C, Marino D, Bollt O, Wu C, Taylor MD, Li W, DeNicola GM, Hao J, Singh PK, Yang S. Fascin promotes lung cancer growth and metastasis by enhancing glycolysis and PFKFB3 expression. Cancer Lett. 2021 10 10; 518:230-242. PMID: 34303764.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    15. Hu T, Shukla SK, Vernucci E, He C, Wang D, King RJ, Jha K, Siddhanta K, Mullen NJ, Attri KS, Murthy D, Chaika NV, Thakur R, Mulder SE, Pacheco CG, Fu X, High RR, Yu F, Lazenby A, Steegborn C, Lan P, Mehla K, Rotili D, Chaudhary S, Valente S, Tafani M, Mai A, Auwerx J, Verdin E, Tuveson D, Singh PK. Metabolic Rewiring by Loss of Sirt5 Promotes Kras-Induced Pancreatic Cancer Progression. Gastroenterology. 2021 11; 161(5):1584-1600. PMID: 34245764.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    16. King RJ, Qiu F, Yu F, Singh PK. Metabolic and Immunological Subtypes of Esophageal Cancer Reveal Potential Therapeutic Opportunities. Front Cell Dev Biol. 2021; 9:667852. PMID: 34307352.
      Citations: 1     
    17. Derakhshani A, Hashemzadeh S, Asadzadeh Z, Shadbad MA, Rasibonab F, Safarpour H, Jafarlou V, Solimando AG, Racanelli V, Singh PK, Najafi S, Javadrashid D, Brunetti O, Silvestris N, Baradaran B. Cytotoxic T-Lymphocyte Antigen-4 in Colorectal Cancer: Another Therapeutic Side of Capecitabine. Cancers (Basel). 2021 May 17; 13(10). PMID: 34067631.
      Citations: 10     
    18. Ferri-Borgogno S, Barui S, McGee AM, Griffiths T, Singh PK, Piett CG, Ghosh B, Bhattacharyya S, Singhi A, Pradhan K, Verma A, Nagel Z, Maitra A, Gupta S. Paradoxical Role of AT-rich Interactive Domain 1A in Restraining Pancreatic Carcinogenesis. Cancers (Basel). 2020 Sep 21; 12(9). PMID: 32967217.
      Citations: 2     
    19. Mistry RM, Singh PK, Mancini MG, Stossi F, Mancini MA. Single Cell Analysis Of Transcriptionally Active Alleles By Single Molecule FISH. J Vis Exp. 2020 09 20; (163). PMID: 33016938.
      Citations: 1     Fields:    Translation:Cells
    20. Mulder SE, Dasgupta A, King RJ, Abrego J, Attri KS, Murthy D, Shukla SK, Singh PK. JNK signaling contributes to skeletal muscle wasting and protein turnover in pancreatic cancer cachexia. Cancer Lett. 2020 10 28; 491:70-77. PMID: 32735910.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    21. DelGiorno KE, Chung CY, Vavinskaya V, Maurer HC, Novak SW, Lytle NK, Ma Z, Giraddi RR, Wang D, Fang L, Naeem RF, Andrade LR, Ali WH, Tseng H, Tsui C, Gubbala VB, Ridinger-Saison M, Ohmoto M, Erikson GA, O'Connor C, Shokhirev MN, Hah N, Urade Y, Matsumoto I, Kaech SM, Singh PK, Manor U, Olive KP, Wahl GM. Tuft Cells Inhibit Pancreatic Tumorigenesis in Mice by Producing Prostaglandin D2. Gastroenterology. 2020 11; 159(5):1866-1881.e8. PMID: 32717220.
      Citations: 9     Fields:    Translation:HumansAnimals
    22. Lin S, Taylor MD, Singh PK, Yang S. How does fascin promote cancer metastasis? FEBS J. 2021 03; 288(5):1434-1446. PMID: 32657526.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    23. Dasgupta A, Shukla SK, Vernucci E, King RJ, Abrego J, Mulder SE, Mullen NJ, Graves G, Buettner K, Thakur R, Murthy D, Attri KS, Wang D, Chaika NV, Pacheco CG, Rai I, Engle DD, Grandgenett PM, Punsoni M, Reames BN, Teoh-Fitzgerald M, Oberley-Deegan R, Yu F, Klute KA, Hollingsworth MA, Zimmerman MC, Mehla K, Sadoshima J, Tuveson DA, Singh PK. SIRT1-NOX4 signaling axis regulates cancer cachexia. J Exp Med. 2020 07 06; 217(7). PMID: 32441762.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    24. Venkatesulu BP, Sharma A, Pollard-Larkin JM, Sadagopan R, Symons J, Neri S, Singh PK, Tailor R, Lin SH, Krishnan S. Author Correction: Ultra high dose rate (35 Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome. Sci Rep. 2020 Jun 30; 10(1):11018. PMID: 32601350.
      Citations: 2     Fields:    
    25. Mundry CS, Eberle KC, Singh PK, Hollingsworth MA, Mehla K. Local and systemic immunosuppression in pancreatic cancer: Targeting the stalwarts in tumor's arsenal. Biochim Biophys Acta Rev Cancer. 2020 08; 1874(1):188387. PMID: 32579889.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    26. Stossi F, Mistry RM, Singh PK, Johnson HL, Mancini MG, Szafran AT, Mancini MA. Single-Cell Distribution Analysis of AR Levels by High-Throughput Microscopy in Cell Models: Application for Testing Endocrine-Disrupting Chemicals. SLAS Discov. 2020 08; 25(7):684-694. PMID: 32552291.
      Citations: 1     Fields:    Translation:Humans
    27. Yamada KJ, Heim CE, Xi X, Attri KS, Wang D, Zhang W, Singh PK, Bronich TK, Kielian T. Monocyte metabolic reprogramming promotes pro-inflammatory activity and Staphylococcus aureus biofilm clearance. PLoS Pathog. 2020 03; 16(3):e1008354. PMID: 32142554.
      Citations: 20     Fields:    Translation:AnimalsCells
    28. Pathak D, Choudhary S, Singh PK, Singh M, Chadha N, Silakari O. Pharmacophore-based designing of putative ROS-1 targeting agents for NSCLC. Mol Divers. 2021 May; 25(2):1091-1102. PMID: 32002714.
      Citations: 2     Fields:    Translation:HumansCells
    29. Vernucci E, Abrego J, Gunda V, Shukla SK, Dasgupta A, Rai V, Chaika N, Buettner K, Illies A, Yu F, Lazenby AJ, Swanson BJ, Singh PK. Metabolic Alterations in Pancreatic Cancer Progression. Cancers (Basel). 2019 Dec 18; 12(1). PMID: 31861288.
      Citations: 11     
    30. Venkatesulu BP, Sharma A, Pollard-Larkin JM, Sadagopan R, Symons J, Neri S, Singh PK, Tailor R, Lin SH, Krishnan S. Ultra high dose rate (35?Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome. Sci Rep. 2019 11 20; 9(1):17180. PMID: 31748640.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    31. Lin S, Huang C, Sun J, Bollt O, Wang X, Martine E, Kang J, Taylor MD, Fang B, Singh PK, Koomen J, Hao J, Yang S. The mitochondrial deoxyguanosine kinase is required for cancer cell stemness in lung adenocarcinoma. EMBO Mol Med. 2019 12; 11(12):e10849. PMID: 31633874.
      Citations: 11     Fields:    Translation:HumansCells
    32. Lin S, Huang C, Gunda V, Sun J, Chellappan SP, Li Z, Izumi V, Fang B, Koomen J, Singh PK, Hao J, Yang S. Fascin Controls Metastatic Colonization and Mitochondrial Oxidative Phosphorylation by Remodeling Mitochondrial Actin Filaments. Cell Rep. 2019 09 10; 28(11):2824-2836.e8. PMID: 31509745.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    33. Laschanzky RS, Humphrey LE, Ma J, Smith LM, Enke TJ, Shukla SK, Dasgupta A, Singh PK, Howell GM, Brattain MG, Ly QP, Black AR, Black JD. Selective Inhibition of Histone Deacetylases 1/2/6 in Combination with Gemcitabine: A Promising Combination for Pancreatic Cancer Therapy. Cancers (Basel). 2019 Sep 07; 11(9). PMID: 31500290.
      Citations: 6     
    34. Hsieh MH, Choe JH, Gadhvi J, Kim YJ, Arguez MA, Palmer M, Gerold H, Nowak C, Do H, Mazambani S, Knighton JK, Cha M, Goodwin J, Kang MK, Jeong JY, Lee SY, Faubert B, Xuan Z, Abel ED, Scafoglio C, Shackelford DB, Minna JD, Singh PK, Shulaev V, Bleris L, Hoyt K, Kim J, Inoue M, DeBerardinis RJ, Kim TH, Kim JW. p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas. Cell Rep. 2019 08 13; 28(7):1860-1878.e9. PMID: 31412252.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    35. Singh PK, Deorukhkar AA, Venkatesulu BP, Li X, Tailor R, Bomalaski JS, Krishnan S. Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation. Mol Cancer Ther. 2019 12; 18(12):2381-2393. PMID: 31395686.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    36. Veeranki OL, Tong Z, Dokey R, Mejia A, Zhang J, Qiao Y, Singh PK, Katkhuda R, Mino B, Tailor R, Canales JR, Bassett R, Ajani J, Wu JY, Kopetz S, Blum M, Hofstetter W, Tetzlaff M, Krishnan S, Lin SH, Maru D. Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma. Oncotarget. 2019 Jul 23; 10(45):4703-4718. PMID: 31384397.
      Citations: 4     Fields:    
    37. Hu H, Petrosyan A, Osna NA, Liu T, Olou AA, Alakhova DY, Singh PK, Kabanov AV, Faber EA, Bronich TK. Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors. J Control Release. 2019 07 28; 306:149-164. PMID: 31121280.
      Citations: 1     Fields:    Translation:AnimalsCells
    38. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019 Apr 16; 50(4):1115. PMID: 30995496.
      Citations: 14     Fields:    
    39. Li X, Gong W, Wang H, Li T, Attri KS, Lewis RE, Kalil AC, Bhinderwala F, Powers R, Yin G, Herring LE, Asara JM, Lei YL, Yang X, Rodriguez DA, Yang M, Green DR, Singh PK, Wen H. O-GlcNAc Transferase Suppresses Inflammation and Necroptosis by Targeting Receptor-Interacting Serine/Threonine-Protein Kinase 3. Immunity. 2019 03 19; 50(3):576-590.e6. PMID: 30770249.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    40. Shukla SK, Dasgupta A, Mulder SE, Singh PK. Molecular and Physiological Evaluation of Pancreatic Cancer-Induced Cachexia. Methods Mol Biol. 2019; 1882:321-333. PMID: 30378066.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    41. Li F, Xu Y, Liu B, Singh PK, Zhao W, Jin J, Han G, Scott AW, Dong X, Huo L, Ma L, Pizzi MP, Wang Y, Li Y, Harada K, Xie M, Skinner HD, Ding S, Wang L, Krishnan S, Johnson RL, Song S, Ajani JA. YAP1-Mediated CDK6 Activation Confers Radiation Resistance in Esophageal Cancer - Rationale for the Combination of YAP1 and CDK4/6 Inhibitors in Esophageal Cancer. Clin Cancer Res. 2019 04 01; 25(7):2264-2277. PMID: 30563933.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    42. Venkatesulu BP, Mahadevan LS, Aliru ML, Yang X, Bodd MH, Singh PK, Yusuf SW, Abe JI, Krishnan S. Radiation-Induced Endothelial Vascular Injury: A Review of Possible Mechanisms. JACC Basic Transl Sci. 2018 Aug; 3(4):563-572. PMID: 30175280.
      Citations: 46     
    43. Chen Y, Bian X, Aliru M, Deorukhkar AA, Ekpenyong O, Liang S, John J, Ma J, Gao X, Schwartz J, Singh P, Ye Y, Krishnan S, Xie H. Hypoxia-targeted gold nanorods for cancer photothermal therapy. Oncotarget. 2018 May 29; 9(41):26556-26571. PMID: 29899876.
      Citations: 6     Fields:    
    44. Saltz J, Gupta R, Hou L, Kurc T, Singh P, Nguyen V, Samaras D, Shroyer KR, Zhao T, Batiste R, Van Arnam J, Shmulevich I, Rao AUK, Lazar AJ, Sharma A, Thorsson V. Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images. Cell Rep. 2018 04 03; 23(1):181-193.e7. PMID: 29617659.
      Citations: 220     Fields:    Translation:HumansCells
    45. Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas T, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, Abe JI. Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation. Front Cardiovasc Med. 2018; 5:23. PMID: 29594152.
      Citations: 5     
    46. Attri KS, Mehla K, Shukla SK, Singh PK. Microscale Gene Expression Analysis of Tumor-Associated Macrophages. Sci Rep. 2018 02 05; 8(1):2408. PMID: 29402936.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    47. Gunda V, Kumar S, Dasgupta A, Singh PK. Hypoxia-Induced Metabolomic Alterations in Pancreatic Cancer Cells. Methods Mol Biol. 2018; 1742:95-105. PMID: 29330793.
      Citations: 8     Fields:    Translation:HumansCells
    48. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 09 11; 32(3):392. PMID: 28898700.
      Citations: 29     Fields:    
    49. Tadros S, Shukla SK, King RJ, Gunda V, Vernucci E, Abrego J, Chaika NV, Yu F, Lazenby AJ, Berim L, Grem J, Sasson AR, Singh PK. De Novo Lipid Synthesis Facilitates Gemcitabine Resistance through Endoplasmic Reticulum Stress in Pancreatic Cancer. Cancer Res. 2017 10 15; 77(20):5503-5517. PMID: 28811332.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    50. Gunda V, Souchek J, Abrego J, Shukla SK, Goode GD, Vernucci E, Dasgupta A, Chaika NV, King RJ, Li S, Wang S, Yu F, Bessho T, Lin C, Singh PK. MUC1-Mediated Metabolic Alterations Regulate Response to Radiotherapy in Pancreatic Cancer. Clin Cancer Res. 2017 Oct 01; 23(19):5881-5891. PMID: 28720669.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    51. Shukla SK, Purohit V, Mehla K, Gunda V, Chaika NV, Vernucci E, King RJ, Abrego J, Goode GD, Dasgupta A, Illies AL, Gebregiworgis T, Dai B, Augustine JJ, Murthy D, Attri KS, Mashadova O, Grandgenett PM, Powers R, Ly QP, Lazenby AJ, Grem JL, Yu F, Matés JM, Asara JM, Kim JW, Hankins JH, Weekes C, Hollingsworth MA, Serkova NJ, Sasson AR, Fleming JB, Oliveto JM, Lyssiotis CA, Cantley LC, Berim L, Singh PK. MUC1 and HIF-1alpha Signaling Crosstalk Induces Anabolic Glucose Metabolism to Impart Gemcitabine Resistance to Pancreatic Cancer. Cancer Cell. 2017 07 10; 32(1):71-87.e7. PMID: 28697344.
      Citations: 152     Fields:    Translation:HumansCells
    52. Souchek JJ, Davis AL, Hill TK, Holmes MB, Qi B, Singh PK, Kridel SJ, Mohs AM. Combination Treatment with Orlistat-Containing Nanoparticles and Taxanes Is Synergistic and Enhances Microtubule Stability in Taxane-Resistant Prostate Cancer Cells. Mol Cancer Ther. 2017 09; 16(9):1819-1830. PMID: 28615298.
      Citations: 12     Fields:    Translation:HumansCells
    53. Goodwin J, Neugent ML, Lee SY, Choe JH, Choi H, Jenkins DMR, Ruthenborg RJ, Robinson MW, Jeong JY, Wake M, Abe H, Takeda N, Endo H, Inoue M, Xuan Z, Yoo H, Chen M, Ahn JM, Minna JD, Helke KL, Singh PK, Shackelford DB, Kim JW. The distinct metabolic phenotype of lung squamous cell carcinoma defines selective vulnerability to glycolytic inhibition. Nat Commun. 2017 05 26; 8:15503. PMID: 28548087.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    54. King RJ, Yu F, Singh PK. Genomic alterations in mucins across cancers. Oncotarget. 2017 Sep 15; 8(40):67152-67168. PMID: 28978023.
      Citations: 17     Fields:    
    55. Goode G, Gunda V, Chaika NV, Purohit V, Yu F, Singh PK. MUC1 facilitates metabolomic reprogramming in triple-negative breast cancer. PLoS One. 2017; 12(5):e0176820. PMID: 28464016.
      Citations: 14     Fields:    Translation:HumansCells
    56. Abrego J, Gunda V, Vernucci E, Shukla SK, King RJ, Dasgupta A, Goode G, Murthy D, Yu F, Singh PK. GOT1-mediated anaplerotic glutamine metabolism regulates chronic acidosis stress in pancreatic cancer cells. Cancer Lett. 2017 08 01; 400:37-46. PMID: 28455244.
      Citations: 34     Fields:    Translation:HumansCells
    57. Jain P, Singh PK, Kapoor R, Khanna A, Solanke AU, Krishnan SG, Singh AK, Sharma V, Sharma TR. Understanding Host-Pathogen Interactions with Expression Profiling of NILs Carrying Rice-Blast Resistance Pi9 Gene. Front Plant Sci. 2017; 8:93. PMID: 28280498.
      Citations: 14     
    58. Xu H, Jia F, Singh PK, Ruan S, Zhang H, Li X. Synergistic anti-glioma effect of a coloaded nano-drug delivery system. Int J Nanomedicine. 2017; 12:29-40. PMID: 28031711.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    59. Chadha AS, Skinner HD, Gunther JR, Munsell MF, Das P, Minsky BD, Delclos ME, Chatterjee D, Wang H, Clemons M, George G, Singh PK, Katz MH, Fleming JB, Javle MM, Wolff RA, Varadhachary GR, Crane CH, Krishnan S. Phase I Trial of Consolidative Radiotherapy with Concurrent Bevacizumab, Erlotinib and Capecitabine for Unresectable Pancreatic Cancer. PLoS One. 2016; 11(6):e0156910. PMID: 27336466.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    60. Gunda V, Yu F, Singh PK. Validation of Metabolic Alterations in Microscale Cell Culture Lysates Using Hydrophilic Interaction Liquid Chromatography (HILIC)-Tandem Mass Spectrometry-Based Metabolomics. PLoS One. 2016; 11(4):e0154416. PMID: 27120458.
      Citations: 17     Fields:    Translation:HumansCells
    61. Mondal G, Kumar V, Shukla SK, Singh PK, Mahato RI. EGFR-Targeted Polymeric Mixed Micelles Carrying Gemcitabine for Treating Pancreatic Cancer. Biomacromolecules. 2016 Jan 11; 17(1):301-13. PMID: 26626700.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    62. Shukla SK, Dasgupta A, Mehla K, Gunda V, Vernucci E, Souchek J, Goode G, King R, Mishra A, Rai I, Nagarajan S, Chaika NV, Yu F, Singh PK. Silibinin-mediated metabolic reprogramming attenuates pancreatic cancer-induced cachexia and tumor growth. Oncotarget. 2015 Dec 01; 6(38):41146-61. PMID: 26510913.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    63. Yang S, Zhang L, Purohit V, Shukla SK, Chen X, Yu F, Fu K, Chen Y, Solheim J, Singh PK, Song W, Dong J. Active YAP promotes pancreatic cancer cell motility, invasion and tumorigenesis in a mitotic phosphorylation-dependent manner through LPAR3. Oncotarget. 2015 Nov 03; 6(34):36019-31. PMID: 26440309.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    64. Pawar VK, Gupta S, Singh Y, Meher JG, Sharma K, Singh P, Gupta A, Bora HK, Chaurasia M, Chourasia MK. Pluronic F-127 Stabilised Docetaxel Nanocrystals Improve Apoptosis by Mitochondrial Depolarization in Breast Cancer Cells: Pharmacokinetics and Toxicity Assessment. J Biomed Nanotechnol. 2015 Oct; 11(10):1747-63. PMID: 26502638.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    65. Singh PK, Krishnan S. Vitamin E Analogs as Radiation Response Modifiers. Evid Based Complement Alternat Med. 2015; 2015:741301. PMID: 26366184.
      Citations: 8     
    66. Shukla SK, Gunda V, Abrego J, Haridas D, Mishra A, Souchek J, Chaika NV, Yu F, Sasson AR, Lazenby AJ, Batra SK, Singh PK. MUC16-mediated activation of mTOR and c-Myc reprograms pancreatic cancer metabolism. Oncotarget. 2015 Aug 07; 6(22):19118-31. PMID: 26046375.
      Citations: 32     Fields:    Translation:HumansCells
    67. Pawar VK, Panchal SB, Singh Y, Meher JG, Sharma K, Singh P, Bora HK, Singh A, Datta D, Chourasia MK. Immunotherapeutic vitamin E nanoemulsion synergies the antiproliferative activity of paclitaxel in breast cancer cells via modulating Th1 and Th2 immune response. J Control Release. 2014 Dec 28; 196:295-306. PMID: 25459427.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    68. Chatterjee DK, Wolfe T, Lee J, Brown AP, Singh PK, Bhattarai SR, Diagaradjane P, Krishnan S. Convergence of nanotechnology with radiation therapy-insights and implications for clinical translation. Transl Cancer Res. 2013 Aug 23; 2(4):256-268. PMID: 25279336.
      Citations: 9     
    69. Singh VK, Wise SY, Singh PK, Posarac A, Fatanmi OO, Ducey EJ, Bolduc DL, Elliott TB, Seed TM. Alpha-tocopherol succinate-mobilized progenitors improve intestinal integrity after whole body irradiation. Int J Radiat Biol. 2013 May; 89(5):334-45. PMID: 23270472.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    70. Dey P, Rachagani S, Chakraborty S, Singh PK, Zhao X, Gurumurthy CB, Anderson JM, Lele S, Hollingsworth MA, Band V, Batra SK. Overexpression of ecdysoneless in pancreatic cancer and its role in oncogenesis by regulating glycolysis. Clin Cancer Res. 2012 Nov 15; 18(22):6188-98. PMID: 22977192.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    71. Torres MP, Rachagani S, Purohit V, Pandey P, Joshi S, Moore ED, Johansson SL, Singh PK, Ganti AK, Batra SK. Graviola: a novel promising natural-derived drug that inhibits tumorigenicity and metastasis of pancreatic cancer cells in vitro and in vivo through altering cell metabolism. Cancer Lett. 2012 Oct 01; 323(1):29-40. PMID: 22475682.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    72. Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D, Anderson JM, Yeh JJ, Johnson KR, Hollingsworth MA, Singh PK. Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One. 2012; 7(3):e32996. PMID: 22412968.
      Citations: 52     Fields:    Translation:HumansCells
    73. Singh VK, Wise SY, Singh PK, Ducey EJ, Fatanmi OO, Seed TM. a-Tocopherol succinate- and AMD3100-mobilized progenitors mitigate radiation-induced gastrointestinal injury in mice. Exp Hematol. 2012 May; 40(5):407-17. PMID: 22240608.
      Citations: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    74. Singh VK, Ducey EJ, Fatanmi OO, Singh PK, Brown DS, Purmal A, Shakhova VV, Gudkov AV, Feinstein E, Shakhov A. CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure. Radiat Res. 2012 May; 177(5):628-42. PMID: 22175300.
      Citations: 25     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    75. Singh PK, Wise SY, Ducey EJ, Fatanmi OO, Elliott TB, Singh VK. a-Tocopherol succinate protects mice against radiation-induced gastrointestinal injury. Radiat Res. 2012 Feb; 177(2):133-45. PMID: 22013885.
      Citations: 23     Fields:    Translation:AnimalsPHPublic Health
    76. Eggers JP, Grandgenett PM, Collisson EC, Lewallen ME, Tremayne J, Singh PK, Swanson BJ, Andersen JM, Caffrey TC, High RR, Ouellette M, Hollingsworth MA. Cyclin-dependent kinase 5 is amplified and overexpressed in pancreatic cancer and activated by mutant K-Ras. Clin Cancer Res. 2011 Oct 01; 17(19):6140-50. PMID: 21825040.
      Citations: 39     Fields:    Translation:HumansCells
    77. Singh PK, Kumar R, Sharma A, Arora R, Chawla R, Jain SK, Tripathi RP, Sharma RK. Role of Apoptotic Proteins in REC-2006 Mediated Radiation Protection in Hepatoma Cell Lines. Evid Based Complement Alternat Med. 2011; 2011:758326. PMID: 21799693.
      Citations: 1     
    78. Gupta ML, Sankhwar S, Verma S, Devi M, Samanta N, Agrawala PK, Kumar R, Singh PK. Whole body protection to lethally irradiated mice by oral administration of semipurified fraction of Podophyllum hexandrum and post irradiation treatment of Picrorhiza kurroa. Tokai J Exp Clin Med. 2008 Apr 20; 33(1):6-12. PMID: 21318957.
      Citations: 5     Fields:    Translation:AnimalsPHPublic Health
    79. Swanson BJ, McDermott KM, Singh PK, Eggers JP, Crocker PR, Hollingsworth MA. MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion. Cancer Res. 2007 Nov 01; 67(21):10222-9. PMID: 17974963.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    80. Singh PK, Wen Y, Swanson BJ, Shanmugam K, Kazlauskas A, Cerny RL, Gendler SJ, Hollingsworth MA. Platelet-derived growth factor receptor beta-mediated phosphorylation of MUC1 enhances invasiveness in pancreatic adenocarcinoma cells. Cancer Res. 2007 Jun 01; 67(11):5201-10. PMID: 17545600.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    81. Singh PK, Hollingsworth MA. Cell surface-associated mucins in signal transduction. Trends Cell Biol. 2006 Sep; 16(9):467-76. PMID: 16904320.
      Citations: 176     Fields:    Translation:HumansAnimalsCells
    82. Tsutsumida H, Swanson BJ, Singh PK, Caffrey TC, Kitajima S, Goto M, Yonezawa S, Hollingsworth MA. RNA interference suppression of MUC1 reduces the growth rate and metastatic phenotype of human pancreatic cancer cells. Clin Cancer Res. 2006 May 15; 12(10):2976-87. PMID: 16707592.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    83. Synergistic anti-glioma effect of a coloaded nano-drug delivery system. International Journal of Nanomedicine. 12:29-40.
    84. Phase i trial of consolidative radiotherapy with concurrent bevacizumab, erlotinib and capecitabine for unresectable pancreatic cancer. PLoS One. 11.
    85. Vitamin E analogs as radiation response modifiers. Evidence-based Complementary and Alternative Medicine. 2015.
    86. Convergence of nanotechnology with radiation therapy-insights and implications for clinical translation. Translational Cancer Research. 2:256-268.
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