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ZAMAL AHMED

TitleAssistant Professor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lin CC, Wieteska L, Suen KM, Kalverda AP, Ahmed Z, Ladbury JE. Grb2 binding induces phosphorylation-independent activation of Shp2. Commun Biol. 2021 Apr 01; 4(1):437. PMID: 33795832.
      Citations:    
    2. Brosey CA, Houl JH, Katsonis P, Balapiti-Modarage LPF, Bommagani S, Arvai A, Moiani D, Bacolla A, Link T, Warden LS, Lichtarge O, Jones DE, Ahmed Z, Tainer JA. Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors. Prog Biophys Mol Biol. 2021 08; 163:171-186. PMID: 33636189.
      Citations:    Fields:    Translation:HumansCells
    3. Bacolla A, Sengupta S, Ye Z, Yang C, Mitra J, De-Paula RB, Hegde ML, Ahmed Z, Mort M, Cooper DN, Mitra S, Tainer JA. Heritable pattern of oxidized DNA base repair coincides with pre-targeting of repair complexes to open chromatin. Nucleic Acids Res. 2021 01 11; 49(1):221-243. PMID: 33300026.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    4. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085.
      Citations: 19     Fields:    Translation:HumansCells
    5. Bacolla A, Ye Z, Ahmed Z, Tainer JA. Cancer mutational burden is shaped by G4 DNA, replication stress and mitochondrial dysfunction. Prog Biophys Mol Biol. 2019 10; 147:47-61. PMID: 30880007.
      Citations: 10     Fields:    Translation:HumansCells
    6. Honda A, Kita T, Seshadri SV, Misaki K, Ahmed Z, Ladbury JE, Richardson GP, Yonemura S, Ladher RK. FGFR1-mediated protocadherin-15 loading mediates cargo specificity during intraflagellar transport in inner ear hair-cell kinocilia. Proc Natl Acad Sci U S A. 2018 08 14; 115(33):8388-8393. PMID: 30061390.
      Citations: 5     Fields:    Translation:AnimalsCells
    7. Brosey CA, Ahmed Z, Lees-Miller SP, Tainer JA. What Combined Measurements From Structures and Imaging Tell Us About DNA Damage Responses. Methods Enzymol. 2017; 592:417-455. PMID: 28668129.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee Iv GR, Lin CC, Gagea M, Marti AA, Ladbury JE. Corrigendum: Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun. 2015 Aug 03; 6:8007. PMID: 26234419.
      Citations: 2     Fields:    
    9. Ahmed Z, Timsah Z, Suen KM, Cook NP, Lee GR, Lin CC, Gagea M, Marti AA, Ladbury JE. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nat Commun. 2015 Jun 24; 6:7354. PMID: 26103942.
      Citations: 12     Fields:    Translation:HumansCells
    10. Bagheri-Yarmand R, Sinha KM, Gururaj AE, Ahmed Z, Rizvi YQ, Huang SC, Ladbury JE, Bogler O, Williams MD, Cote GJ, Gagel RF. A novel dual kinase function of the RET proto-oncogene negatively regulates activating transcription factor 4-mediated apoptosis. J Biol Chem. 2015 May 01; 290(18):11749-61. PMID: 25795775.
      Citations: 13     Fields:    Translation:HumansCells
    11. Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD. Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS One. 2014; 9(1):e86784. PMID: 24475179.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Timsah Z, Ahmed Z, Lin CC, Melo FA, Stagg LJ, Leonard PG, Jeyabal P, Berrout J, O'Neil RG, Bogdanov M, Ladbury JE. Competition between Grb2 and Plc?1 for FGFR2 regulates basal phospholipase activity and invasion. Nat Struct Mol Biol. 2014 Feb; 21(2):180-8. PMID: 24440983.
      Citations: 20     Fields:    Translation:HumansCells
    13. Cimo AM, Ahmed Z, McIntyre BW, Lewis DE, Ladbury JE. CD25 and CD69 induction by a4ß1 outside-in signalling requires TCR early signalling complex proteins. Biochem J. 2013 Aug 15; 454(1):109-21. PMID: 23758320.
      Citations: 3     Fields:    Translation:HumansCells
    14. Suen KM, Lin CC, George R, Melo FA, Biggs ER, Ahmed Z, Drake MN, Arur S, Arold ST, Ladbury JE. Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nat Struct Mol Biol. 2013 May; 20(5):620-7. PMID: 23584453.
      Citations: 14     Fields:    Translation:HumansCells
    15. Ahmed Z, Lin CC, Suen KM, Melo FA, Levitt JA, Suhling K, Ladbury JE. Grb2 controls phosphorylation of FGFR2 by inhibiting receptor kinase and Shp2 phosphatase activity. J Cell Biol. 2013 Feb 18; 200(4):493-504. PMID: 23420874.
      Citations: 28     Fields:    Translation:HumansCells
    16. Lin CC, Melo FA, Ghosh R, Suen KM, Stagg LJ, Kirkpatrick J, Arold ST, Ahmed Z, Ladbury JE. Inhibition of basal FGF receptor signaling by dimeric Grb2. Cell. 2012 Jun 22; 149(7):1514-24. PMID: 22726438.
      Citations: 66     Fields:    Translation:HumansCells
    17. Stevens CN, Simeone AM, John S, Ahmed Z, Lucherini OM, Baldari CT, Ladbury JE. T-cell receptor early signalling complex activation in response to interferon-alpha receptor stimulation. Biochem J. 2010 May 27; 428(3):429-37. PMID: 20388118.
      Citations: 3     Fields:    Translation:HumansCells
    18. Ahmed Z, George R, Lin CC, Suen KM, Levitt JA, Suhling K, Ladbury JE. Direct binding of Grb2 SH3 domain to FGFR2 regulates SHP2 function. Cell Signal. 2010 Jan; 22(1):23-33. PMID: 19735729.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    19. Schüller AC, Ahmed Z, Levitt JA, Suen KM, Suhling K, Ladbury JE. Indirect recruitment of the signalling adaptor Shc to the fibroblast growth factor receptor 2 (FGFR2). Biochem J. 2008 Dec 01; 416(2):189-99. PMID: 18840094.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    20. Ahmed Z, Schüller AC, Suhling K, Tregidgo C, Ladbury JE. Extracellular point mutations in FGFR2 elicit unexpected changes in intracellular signalling. Biochem J. 2008 Jul 01; 413(1):37-49. PMID: 18373495.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    21. Schüller AC, Ahmed Z, Ladbury JE. Extracellular point mutations in FGFR2 result in elevated ERK1/2 activation and perturbation of neuronal differentiation. Biochem J. 2008 Feb 15; 410(1):205-11. PMID: 18039182.
      Citations: 8     Fields:    Translation:AnimalsCells
    22. Ahmed Z, Beeton CA, Williams MA, Clements D, Baldari CT, Ladbury JE. Distinct spatial and temporal distribution of ZAP70 and Lck following stimulation of interferon and T-cell receptors. J Mol Biol. 2005 Nov 11; 353(5):1001-10. PMID: 16219325.
      Citations: 6     Fields:    Translation:HumansCells
    23. Grb2 monomer-dimer equilibrium determines normal versus oncogenic function. Nature Communications. 6.
    24. Erratum. Nature Communications. 6.
    25. Interaction with Shc prevents aberrant Erk activation in the absence of extracellular stimuli. Nature Structural and Molecular Biology.
    26. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene.
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