TAKASHI SHINGU

TitleInstructor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Shin S, Zhou H, He C, Wei Y, Wang Y, Shingu T, Zeng A, Wang S, Zhou X, Li H, Zhang Q, Mo Q, Long J, Lan F, Chen Y, Hu J. Qki activates Srebp2-mediated cholesterol biosynthesis for maintenance of eye lens transparency. Nat Commun. 2021 05 21; 12(1):3005. PMID: 34021134.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Zhou X, Shin S, He C, Zhang Q, Rasband MN, Ren J, Dai C, Zorrilla-Veloz RI, Shingu T, Yuan L, Wang Y, Chen Y, Lan F, Hu J. Qki regulates myelinogenesis through Srebp2-dependent cholesterol biosynthesis. Elife. 2021 May 04; 10. PMID: 33942715.
      Citations:    Fields:    
    3. Inoue A, Robinson FS, Minelli R, Tomihara H, Rizi BS, Rose JL, Kodama T, Srinivasan S, Harris AL, Zuniga AM, Mullinax RA, Ma X, Seth S, Daniele JR, Peoples MD, Loponte S, Akdemir KC, Khor TO, Feng N, Roszik J, Sobieski MM, Brunell D, Stephan C, Giuliani V, Deem AK, Shingu T, Deribe YL, Menter DG, Heffernan TP, Viale A, Bristow CA, Kopetz S, Draetta GF, Genovese G, Carugo A. Sequential Administration of XPO1 and ATR Inhibitors Enhances Therapeutic Response in TP53-mutated Colorectal Cancer. Gastroenterology. 2021 Jul; 161(1):196-210. PMID: 33745946.
      Citations:    Fields:    
    4. Ren J, Dai C, Zhou X, Barnes JA, Chen X, Wang Y, Yuan L, Shingu T, Heimberger AB, Chen Y, Hu J. Qki is an essential regulator of microglial phagocytosis in demyelination. J Exp Med. 2021 01 04; 218(1). PMID: 33045062.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Zhou X, He C, Ren J, Dai C, Stevens SR, Wang Q, Zamler D, Shingu T, Yuan L, Chandregowda CR, Wang Y, Ravikumar V, Rao AU, Zhou F, Zheng H, Rasband MN, Chen Y, Lan F, Heimberger AB, Segal BM, Hu J. Mature myelin maintenance requires Qki to coactivate PPARß-RXRa-mediated lipid metabolism. J Clin Invest. 2020 05 01; 130(5):2220-2236. PMID: 32202512.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    6. Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 01; 49(1):75-86. PMID: 27841882.
      Citations: 33     Fields:    Translation:AnimalsCells
    7. Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med. 2016 Feb 09; 14:46. PMID: 26861698.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells Int. 2016; 2016:7849890. PMID: 26880988.
      Citations: 64     
    9. Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J. Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer. J Vis Exp. 2015 Apr 13; (98). PMID: 25938254.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, Ogasawara M, Keating MJ, Kondo S, Huang P. Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011 Sep 16; 286(37):32843-53. PMID: 21795717.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    11. Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. Int J Cancer. 2011 Feb 15; 128(4):787-96. PMID: 20473884.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    12. Shingu T, Chumbalkar VC, Gwak HS, Fujiwara K, Kondo S, Farrell NP, Bogler O. The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro Oncol. 2010 Dec; 12(12):1269-77. PMID: 20713409.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    13. Shingu T, Fujiwara K, Bögler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy. 2009 May; 5(4):537-9. PMID: 19270491.
      Citations: 16     Fields:    Translation:Humans
    14. Shingu T, Fujiwara K, Bögler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer. 2009 Mar 01; 124(5):1060-71. PMID: 19048625.
      Citations: 61     Fields:    Translation:HumansCells
    15. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Autophagy. 2008 May; 4(4):467-75. PMID: 18259115.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    16. Shingu T, Akiyama Y, Daisu M, Maruyama N, Matsumoto Y, Miyazaki T, Nagai H, Yamamoto Y, Yamasaki T, Yoshida M, Maruyama R, Moritake K. Symptomatic hemorrhage associated with recurrent pilocytic astrocytoma with granulation tissue--case report. Neurol Med Chir (Tokyo). 2007 May; 47(5):222-8. PMID: 17527050.
      Citations: 2     Fields:    Translation:Humans
    17. Shingu T, Kagawa T, Kimura Y, Takada D, Moritake K, Hoshii Y. Supratentorial primitive neuroectodermal tumor in an aged patient--case report--. Neurol Med Chir (Tokyo). 2005 Oct; 45(10):530-5. PMID: 16247240.
      Citations: 9     Fields:    Translation:Humans
    18. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res. 2003 Jul 15; 63(14):4044-7. PMID: 12874004.
      Citations: 19     Fields:    Translation:HumansCells
    19. Yamasaki T, Moritake K, Nagai H, Uemura T, Shingu T, Matsumoto Y. A new, miniature ultrasonic surgical aspirator with a handpiece designed for transsphenoidal surgery. Technical note. J Neurosurg. 2003 Jul; 99(1):177-9. PMID: 12854763.
      Citations: 1     Fields:    Translation:Humans
    20. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. J Neurosurg. 2003 Jan; 98(1):154-61. PMID: 12546364.
      Citations: 10     Fields:    Translation:HumansCells
    21. Uemura T, Moritake K, Akiyama Y, Kimura Y, Shingu T, Yamasaki T. Experimental validation of deuterium oxide-mediated antitumoral activity as it relates to apoptosis in murine malignant astrocytoma cells. J Neurosurg. 2002 May; 96(5):900-8. PMID: 12005398.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    22. Glioma Stem Cells. Stem Cells International. 2016.
    23. Pharmacokinetic analysis of etoposide concentration in intracranial tumor cavity after intravenous injection in 5 cases of glioblastoma and metastatic brain tumor. Journal of Japan Society for Cancer Therapy. 31:420-426.
    24. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. Journal of Translational Medicine.
    25. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nature Genetics. 49:75-86.
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