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TAKASHI SHINGU

TitleInstructor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shingu T, Ho AL, Yuan L, Zhou X, Dai C, Zheng S, Wang Q, Zhong Y, Chang Q, Horner JW, Liebelt BD, Yao Y, Hu B, Chen Y, Fuller GN, Verhaak RG, Heimberger AB, Hu J. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nat Genet. 2017 01; 49(1):75-86. PMID: 27841882.
      View in: PubMed
    2. Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med. 2016 Feb 09; 14:46. PMID: 26861698; PMCID: PMC4746796.
    3. Liebelt BD, Shingu T, Zhou X, Ren J, Shin SA, Hu J. Glioma Stem Cells: Signaling, Microenvironment, and Therapy. Stem Cells Int. 2016; 2016:7849890. PMID: 26880988.
      View in: PubMed
    4. Shingu T, Jaskelioff M, Yuan L, Ding Z, Protopopov A, Kost-Alimova M, Hu J. Utilizing murine inducible telomerase alleles in the studies of tissue degeneration/regeneration and cancer. J Vis Exp. 2015 Apr 13; (98). PMID: 25938254; PMCID: PMC4526143.
    5. Zhou Y, Zhou Y, Shingu T, Feng L, Chen Z, Ogasawara M, Keating MJ, Kondo S, Huang P. Metabolic alterations in highly tumorigenic glioblastoma cells: preference for hypoxia and high dependency on glycolysis. J Biol Chem. 2011 Sep 16; 286(37):32843-53. PMID: 21795717; PMCID: PMC3173179.
    6. Gwak HS, Shingu T, Chumbalkar V, Hwang YH, DeJournett R, Latha K, Koul D, Alfred Yung WK, Powis G, Farrell NP, Bögler O. Combined action of the dinuclear platinum compound BBR3610 with the PI3-K inhibitor PX-866 in glioblastoma. Int J Cancer. 2011 Feb 15; 128(4):787-96. PMID: 20473884; PMCID: PMC2990813.
    7. Shingu T, Chumbalkar VC, Gwak HS, Fujiwara K, Kondo S, Farrell NP, Bogler O. The polynuclear platinum BBR3610 induces G2/M arrest and autophagy early and apoptosis late in glioma cells. Neuro Oncol. 2010 Dec; 12(12):1269-77. PMID: 20713409; PMCID: PMC3018945.
    8. Shingu T, Fujiwara K, Bögler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Stage-specific effect of inhibition of autophagy on chemotherapy-induced cytotoxicity. Autophagy. 2009 May; 5(4):537-9. PMID: 19270491.
      View in: PubMed
    9. Shingu T, Fujiwara K, Bögler O, Akiyama Y, Moritake K, Shinojima N, Tamada Y, Yokoyama T, Kondo S. Inhibition of autophagy at a late stage enhances imatinib-induced cytotoxicity in human malignant glioma cells. Int J Cancer. 2009 Mar 01; 124(5):1060-71. PMID: 19048625.
      View in: PubMed
    10. Aoki H, Kondo Y, Aldape K, Yamamoto A, Iwado E, Yokoyama T, Hollingsworth EF, Kobayashi R, Hess K, Shinojima N, Shingu T, Tamada Y, Zhang L, Conrad C, Bogler O, Mills G, Sawaya R, Kondo S. Monitoring autophagy in glioblastoma with antibody against isoform B of human microtubule-associated protein 1 light chain 3. Autophagy. 2008 May; 4(4):467-75. PMID: 18259115.
      View in: PubMed
    11. Shingu T, Akiyama Y, Daisu M, Maruyama N, Matsumoto Y, Miyazaki T, Nagai H, Yamamoto Y, Yamasaki T, Yoshida M, Maruyama R, Moritake K. Symptomatic hemorrhage associated with recurrent pilocytic astrocytoma with granulation tissue--case report. Neurol Med Chir (Tokyo). 2007 May; 47(5):222-8. PMID: 17527050.
      View in: PubMed
    12. Shingu T, Kagawa T, Kimura Y, Takada D, Moritake K, Hoshii Y. Supratentorial primitive neuroectodermal tumor in an aged patient--case report--. Neurol Med Chir (Tokyo). 2005 Oct; 45(10):530-5. PMID: 16247240.
      View in: PubMed
    13. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Synergistic augmentation of antimicrotubule agent-induced cytotoxicity by a phosphoinositide 3-kinase inhibitor in human malignant glioma cells. Cancer Res. 2003 Jul 15; 63(14):4044-7. PMID: 12874004.
      View in: PubMed
    14. Yamasaki T, Moritake K, Nagai H, Uemura T, Shingu T, Matsumoto Y. A new, miniature ultrasonic surgical aspirator with a handpiece designed for transsphenoidal surgery. Technical note. J Neurosurg. 2003 Jul; 99(1):177-9. PMID: 12854763.
      View in: PubMed
    15. Shingu T, Yamada K, Hara N, Moritake K, Osago H, Terashima M, Uemura T, Yamasaki T, Tsuchiya M. Growth inhibition of human malignant glioma cells induced by the PI3-K-specific inhibitor. J Neurosurg. 2003 Jan; 98(1):154-61. PMID: 12546364.
      View in: PubMed
    16. Uemura T, Moritake K, Akiyama Y, Kimura Y, Shingu T, Yamasaki T. Experimental validation of deuterium oxide-mediated antitumoral activity as it relates to apoptosis in murine malignant astrocytoma cells. J Neurosurg. 2002 May; 96(5):900-8. PMID: 12005398.
      View in: PubMed
    17. Kondo S, Mishiro N, Umeki K, Kotani T, Setoguchi M, Shingu T, Ohtaki S. Human T-lymphotropic virus type I (HTLV-I) DNA in an HTLV-I-endemic area (Miyazaki, Japan) Transfusion. 1994 May; 34(5):449-50. PMID: 8191572.
      View in: PubMed
    18. Matsumoto S, Yamamoto T, Ban S, Motozaki T, Sato S, Shingu T, Yoshida S, Tsuiki H. Spontaneous subperiosteal hematoma of the orbit--case report. Neurol Med Chir (Tokyo). 1994 Jan; 34(1):27-9. PMID: 7514750.
      View in: PubMed
    19. Wu TS, Lin YM, Haruna M, Pan DJ, Shingu T, Chen YP, Hsu HY, Nakano T, Lee KH. Antitumor agents, 119. Kansuiphorins A and B, two novel antileukemic diterpene esters from Euphorbia kansui. J Nat Prod. 1991 May-Jun; 54(3):823-9. PMID: 1955882.
      View in: PubMed
    20. Gi H, Nagao S, Yoshizumi H, Nishioka T, Uno J, Shingu T, Fujita Y. Meningioma with hypergammaglobulinemia. Case report. J Neurosurg. 1990 Oct; 73(4):628-9. PMID: 2398394.
      View in: PubMed
    21. Yamada K, Matsunaga M, Fujita Y, Araki O, Shingu T, Gi H. [Brain abscess: successful treatment of 4 cases including one with ventricular perforation]. No Shinkei Geka. 1983 Sep; 11(9):967-73. PMID: 6664453.
      View in: PubMed
    22. Fujita Y, Shingu T, Yamada K, Araki O, Matsunaga M, Mori K, Kawano T. [Noxious free radicals derived from oxyhemoglobin as a cause of prolonged vasospasm]. Neurol Med Chir (Tokyo). 1980 Feb; 20(2):137-44. PMID: 6153765.
      View in: PubMed
    23. Shingu T, Fujita Y, Araki O, Matsumoto Y, Matsunaga M. [99m Tc scan dynamics in cerebral infarcted area--as an indicator of vascular reconstruction (author's transl)]. Neurol Med Chir (Tokyo). 1979 Nov; 19(11):1063-70. PMID: 93246.
      View in: PubMed
    24. Glioma Stem Cells. Stem Cells International. 2016.
    25. Pharmacokinetic analysis of etoposide concentration in intracranial tumor cavity after intravenous injection in 5 cases of glioblastoma and metastatic brain tumor. Journal of Japan Society for Cancer Therapy. 31:420-426.
    26. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. Journal of Translational Medicine.
    27. Qki deficiency maintains stemness of glioma stem cells in suboptimal environment by downregulating endolysosomal degradation. Nature Genetics. 49:75-86.
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