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ZHILIANG JIA

TitleInstructor
InstitutionMD Anderson
DepartmentGastroenterology Hepatology & Nutrition
Address1515 Holcombe Blvd.
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Hu J, Lazar AJ, Ingram D, Wang WL, Zhang W, Jia Z, Ragoonanan D, Wang J, Xia X, Mahadeo K, Gorlick R, Li S. Cell membrane-anchored and tumor-targeted IL-12 T-cell therapy destroys cancer-associated fibroblasts and disrupts extracellular matrix in heterogenous osteosarcoma xenograft models. J Immunother Cancer. 2024 01 09; 12(1). PMID: 38199607; PMCID: PMC10806671.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    2. Jia Z, Ragoonanan D, Mahadeo KM, Gill J, Gorlick R, Shpal E, Li S. IL12 immune therapy clinical trial review: Novel strategies for avoiding CRS-associated cytokines. Front Immunol. 2022; 13:952231. PMID: 36203573; PMCID: PMC9530253.
      Citations: 1     Fields:    Translation:HumansCells
    3. Hu J, Zhao Q, Kong LY, Wang J, Yan J, Xia X, Jia Z, Heimberger AB, Li S. Regulation of tumor immune suppression and cancer cell survival by CXCL1/2 elevation in glioblastoma multiforme. Sci Adv. 2021 01; 7(5). PMID: 33571109; PMCID: PMC7840139.
      Citations: 12     Fields:    Translation:HumansCells
    4. Wang L, Jia Z, Xie D, Zhao T, Tan Z, Zhang S, Kong F, Wei D, Xie K. Methylation of HSP70 Orchestrates Its Binding to and Stabilization of BCL2 mRNA and Renders Pancreatic Cancer Cells Resistant to Therapeutics. Cancer Res. 2020 10 15; 80(20):4500-4513. PMID: 32699135.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Ma L, Lin K, Chang G, Chen Y, Yue C, Guo Q, Zhang S, Jia Z, Huang TT, Zhou A, Huang S. Aberrant Activation of ?-Catenin Signaling Drives Glioma Tumorigenesis via USP1-Mediated Stabilization of EZH2. Cancer Res. 2019 01 01; 79(1):72-85. PMID: 30425057; PMCID: PMC9646285.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    6. Kong F, Kong X, Du Y, Chen Y, Deng X, Zhu J, Du J, Li L, Jia Z, Xie D, Li Z, Xie K. STK33 Promotes Growth and Progression of Pancreatic Cancer as a Critical Downstream Mediator of HIF1a. Cancer Res. 2017 12 15; 77(24):6851-6862. PMID: 29038348.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    7. Xie VK, Li Z, Yan Y, Jia Z, Zuo X, Ju Z, Wang J, Du J, Xie D, Xie K, Wei D. DNA-Methyltransferase 1 Induces Dedifferentiation of Pancreatic Cancer Cells through Silencing of Kr?ppel-Like Factor 4 Expression. Clin Cancer Res. 2017 Sep 15; 23(18):5585-5597. PMID: 28659310; PMCID: PMC5600846.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    8. Wei D, Wang L, Yan Y, Jia Z, Gagea M, Li Z, Zuo X, Kong X, Huang S, Xie K. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 2016 Mar 14; 29(3):324-338. PMID: 26977883; PMCID: PMC4794756.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    9. Yan Y, Li Z, Kong X, Jia Z, Zuo X, Gagea M, Huang S, Wei D, Xie K. KLF4-Mediated Suppression of CD44 Signaling Negatively Impacts Pancreatic Cancer Stemness and Metastasis. Cancer Res. 2016 04 15; 76(8):2419-31. PMID: 26880805; PMCID: PMC4876033.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    10. Sun H, Tang H, Xie D, Jia Z, Ma Z, Wei D, Mishra L, Gao Y, Zheng S, Xie K, Peng Z. Kr?ppel-like Factor 4 Blocks Hepatocellular Carcinoma Dedifferentiation and Progression through Activation of Hepatocyte Nuclear Factor-6. Clin Cancer Res. 2016 Jan 15; 22(2):502-12. PMID: 26338995; PMCID: PMC4715982.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    11. Li Z, Jia Z, Gao Y, Xie D, Wei D, Cui J, Mishra L, Huang S, Zhang Y, Xie K. Activation of vitamin D receptor signaling downregulates the expression of nuclear FOXM1 protein and suppresses pancreatic cancer cell stemness. Clin Cancer Res. 2015 Feb 15; 21(4):844-53. PMID: 25501129; PMCID: PMC4334671.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    12. Shi M, Cui J, Du J, Wei D, Jia Z, Zhang J, Zhu Z, Gao Y, Xie K. A novel KLF4/LDHA signaling pathway regulates aerobic glycolysis in and progression of pancreatic cancer. Clin Cancer Res. 2014 Aug 15; 20(16):4370-80. PMID: 24947925; PMCID: PMC4134726.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    13. Li L, Li Z, Kong X, Xie D, Jia Z, Jiang W, Cui J, Du Y, Wei D, Huang S, Xie K. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and ?-catenin signaling in pancreatic ductal adenocarcinoma cells. Gastroenterology. 2014 Aug; 147(2):485-97.e18. PMID: 24859161.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    14. Cui J, Shi M, Xie D, Wei D, Jia Z, Zheng S, Gao Y, Huang S, Xie K. FOXM1 promotes the warburg effect and pancreatic cancer progression via transactivation of LDHA expression. Clin Cancer Res. 2014 May 15; 20(10):2595-606. PMID: 24634381; PMCID: PMC4024335.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    15. Li L, Du Y, Kong X, Li Z, Jia Z, Cui J, Gao J, Wang G, Xie K. Lamin B1 is a novel therapeutic target of betulinic acid in pancreatic cancer. Clin Cancer Res. 2013 Sep 01; 19(17):4651-61. PMID: 23857605; PMCID: PMC3800003.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    16. Kong X, Li L, Li Z, Le X, Huang C, Jia Z, Cui J, Huang S, Wang L, Xie K. Dysregulated expression of FOXM1 isoforms drives progression of pancreatic cancer. Cancer Res. 2013 Jul 01; 73(13):3987-96. PMID: 23598278; PMCID: PMC3702645.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    17. Li D, Wei P, Peng Z, Huang C, Tang H, Jia Z, Cui J, Le X, Huang S, Xie K. The critical role of dysregulated FOXM1-PLAUR signaling in human colon cancer progression and metastasis. Clin Cancer Res. 2013 Jan 01; 19(1):62-72. PMID: 23136192; PMCID: PMC3537853.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    18. Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K. Dysregulated Kr?ppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma. Gastroenterology. 2012 Sep; 143(3):799-810.e2. PMID: 22677193; PMCID: PMC3653768.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    19. Huang C, Qiu Z, Wang L, Peng Z, Jia Z, Logsdon CD, Le X, Wei D, Huang S, Xie K. A novel FoxM1-caveolin signaling pathway promotes pancreatic cancer invasion and metastasis. Cancer Res. 2012 Feb 01; 72(3):655-65. PMID: 22194465; PMCID: PMC3271134.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    20. Li Q, Jia Z, Wang L, Kong X, Li Q, Guo K, Tan D, Le X, Wei D, Huang S, Mishra L, Xie K. Disruption of Klf4 in villin-positive gastric progenitor cells promotes formation and progression of tumors of the antrum in mice. Gastroenterology. 2012 Mar; 142(3):531-42. PMID: 22155367; PMCID: PMC3477581.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    21. Gao Y, Jia Z, Kong X, Li Q, Chang DZ, Wei D, Le X, Suyun H, Huang S, Wang L, Xie K. Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis. Cancer Res. 2011 Aug 01; 71(15):5182-93. PMID: 21673052; PMCID: PMC3245664.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    22. Wei D, Wang L, Kanai M, Jia Z, Le X, Li Q, Wang H, Xie K. KLF4a up-regulation promotes cell cycle progression and reduces survival time of patients with pancreatic cancer. Gastroenterology. 2010 Dec; 139(6):2135-45. PMID: 20727893; PMCID: PMC3245983.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    23. Jia Z, Gao Y, Wang L, Li Q, Zhang J, Le X, Wei D, Yao JC, Chang DZ, Huang S, Xie K. Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity. Cancer Res. 2010 Feb 01; 70(3):1111-9. PMID: 20086170; PMCID: PMC2840649.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    24. Li Q, Wei D, Wang L, Wang L, Jia Z, Le X, Gao Y, Huang S, Xie K. Modeling liver metastasis using a tumor cell line derived from an enhanced green fluorescent protein transgenic mouse. Clin Exp Metastasis. 2010; 27(1):11-8. PMID: 19882218.
      Citations: 1     Fields:    Translation:AnimalsCells
    25. Li Q, Zhang N, Jia Z, Le X, Dai B, Wei D, Huang S, Tan D, Xie K. Critical role and regulation of transcription factor FoxM1 in human gastric cancer angiogenesis and progression. Cancer Res. 2009 Apr 15; 69(8):3501-9. PMID: 19351851; PMCID: PMC4087044.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    26. Yu G, Wang J, Chen Y, Wang X, Pan J, Li G, Jia Z, Li Q, Yao JC, Xie K. Overexpression of phosphorylated mammalian target of rapamycin predicts lymph node metastasis and prognosis of chinese patients with gastric cancer. Clin Cancer Res. 2009 Mar 01; 15(5):1821-9. PMID: 19223493.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    27. Peng Z, Tang H, Wang X, Zhou C, Fan J, Wang L, Jia Z, Li Q, Le X, Wei D, Xie K. Inhibition of the growth and metastasis of human colon cancer by restoration of RUNX3 expression in cancer cells. Int J Oncol. 2008 Nov; 33(5):979-84. PMID: 18949360.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    28. Wang L, Guan X, Zhang J, Jia Z, Wei D, Li Q, Yao J, Xie K. Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models. Int J Oncol. 2008 Jul; 33(1):161-7. PMID: 18575762.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    29. Wei D, Kanai M, Jia Z, Le X, Xie K. Kruppel-like factor 4 induces p27Kip1 expression in and suppresses the growth and metastasis of human pancreatic cancer cells. Cancer Res. 2008 Jun 15; 68(12):4631-9. PMID: 18559508; PMCID: PMC2481517.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    30. Yuan P, Wang L, Wei D, Zhang J, Jia Z, Li Q, Le X, Wang H, Yao J, Xie K. Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer. Cancer. 2007 Dec 15; 110(12):2682-90. PMID: 17973266.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    31. Jia Z, Zhang J, Wei D, Wang L, Yuan P, Le X, Li Q, Yao J, Xie K. Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A. Cancer Res. 2007 May 15; 67(10):4878-85. PMID: 17510417.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    32. Zhang J, Jia Z, Li Q, Wang L, Rashid A, Zhu Z, Evans DB, Vauthey JN, Xie K, Yao JC. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer. 2007 Apr 15; 109(8):1478-86. PMID: 17340592.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    33. Zhang J, Jiang Y, Jia Z, Li Q, Gong W, Wang L, Wei D, Yao J, Fang S, Xie K. Association of elevated GRP78 expression with increased lymph node metastasis and poor prognosis in patients with gastric cancer. Clin Exp Metastasis. 2006; 23(7-8):401-10. PMID: 17187227.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    34. Peng Z, Wei D, Wang L, Tang H, Zhang J, Le X, Jia Z, Li Q, Xie K. RUNX3 inhibits the expression of vascular endothelial growth factor and reduces the angiogenesis, growth, and metastasis of human gastric cancer. Clin Cancer Res. 2006 Nov 01; 12(21):6386-94. PMID: 17085650.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    35. Kanai M, Wei D, Li Q, Jia Z, Ajani J, Le X, Yao J, Xie K. Loss of Kr?ppel-like factor 4 expression contributes to Sp1 overexpression and human gastric cancer development and progression. Clin Cancer Res. 2006 Nov 01; 12(21):6395-402. PMID: 17085651.
      Citations: 52     Fields:    Translation:HumansCells
    36. KLF4-mediated suppression of CD44 signaling negatively impacts pancreatic cancer stemness and metastasis. Cancer Research. 76:2419-2431.
    37. Merlin/NF2 suppresses pancreatic tumor growth and metastasis by attenuating the FOXM1-mediated Wnt/β-catenin signaling. Cancer Research. 75:4778-4789.
    38. Hippo transducer TAZ promotes epithelial mesenchymal transition and supports pancreatic cancer progression. Oncotarget. 6:35949-35963.
    39. KLF4 Is Essential for Induction of Cellular Identity Change and Acinar-to-Ductal Reprogramming during Early Pancreatic Carcinogenesis. Cancer Cell. 29:324-338.
    40. HGF/Met and FOXM1 form a positive feedback loop and render pancreatic cancer cells resistance to Met inhibition and aggressive phenotypes. Oncogene.
    41. Krüppel-like factor 4 blocks hepatocellular carcinoma dedifferentiation and progression through activation of hepatocyte nuclear factor-6. Clinical Cancer Research. 22:502-512.
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