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Megumi Mathison

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
DivisionSurgery-Surgical Research
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    Heart failure is a leading cause of death in developed countries. Recent advances in interventional cardiology and cardiac surgery have made it possible to save numerous patient lives after myocardial infarction. However, those patients eventually develop end-stage heart failure since the loss of cardiac muscle is never replaced with new muscle. Our study focus is on regenerating cardiac muscle by transdifferentiating cardiac fibroblasts into cardiomyocytes. We reported that Gata4, Mef2c, and Tbx5 overexpression transdifferentiated cardiac fibroblasts into cardiomyocyte-like cells in vitro, and improved cardiac function in vivo. Our goal is to translate this in-situ cardiomyocyte regeneration into clinical therapy.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Patel V, Singh VP, Pinnamaneni JP, Sanagasetti D, Olive J, Mathison M, Cooney A, Flores ER, Crystal RG, Yang J, Rosengart TK. p63 Silencing induces reprogramming of cardiac fibroblasts into cardiomyocyte-like cells. J Thorac Cardiovasc Surg. 2018 08; 156(2):556-565.e1. PMID: 29716728.
      View in: PubMed
    2. Yang L, Liu L, Gao H, Pinnamaneni JP, Sanagasetti D, Singh VP, Wang K, Mathison M, Zhang Q, Chen F, Mo Q, Rosengart T, Yang J. The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis. J Hematol Oncol. 2017 10 03; 10(1):159. PMID: 28974232.
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    3. Mathison M, Rosengart TK. Heart regeneration: The endothelial cell comes first. J Thorac Cardiovasc Surg. 2018 03; 155(3):1128-1129. PMID: 29452462.
      View in: PubMed
    4. Mathison M, Singh VP, Sanagasetti D, Yang L, Pinnamaneni JP, Yang J, Rosengart TK. Cardiac reprogramming factor Gata4 reduces postinfarct cardiac fibrosis through direct repression of the profibrotic mediator snail. J Thorac Cardiovasc Surg. 2017 11; 154(5):1601-1610.e3. PMID: 28711329.
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    5. Singh VP, Mathison M, Patel V, Sanagasetti D, Gibson BW, Yang J, Rosengart TK. MiR-590 Promotes Transdifferentiation of Porcine and Human Fibroblasts Toward a Cardiomyocyte-Like Fate by Directly Repressing Specificity Protein 1. J Am Heart Assoc. 2016 11 10; 5(11). PMID: 27930352.
      View in: PubMed
    6. Mathison M, Singh VP, Chiuchiolo MJ, Sanagasetti D, Mao Y, Patel VB, Yang J, Kaminsky SM, Crystal RG, Rosengart TK. In situ reprogramming to transdifferentiate fibroblasts into cardiomyocytes using adenoviral vectors: Implications for clinical myocardial regeneration. J Thorac Cardiovasc Surg. 2017 02; 153(2):329-339.e3. PMID: 27773576.
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    7. Patel V, Mathison M, Singh VP, Yang J, Rosengart TK. Direct Cardiac Cellular Reprogramming for Cardiac Regeneration. Curr Treat Options Cardiovasc Med. 2016 Sep; 18(9):58. PMID: 27554127.
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    8. Mathison M, Singh VP, Gersch RP, Ramirez MO, Cooney A, Kaminsky SM, Chiuchiolo MJ, Nasser A, Yang J, Crystal RG, Rosengart TK. "Triplet" polycistronic vectors encoding Gata4, Mef2c, and Tbx5 enhances postinfarct ventricular functional improvement compared with singlet vectors. J Thorac Cardiovasc Surg. 2014 Oct; 148(4):1656-1664.e2. PMID: 24755332.
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    9. Mathison M, Gersch RP, Nasser A, Lilo S, Korman M, Fourman M, Hackett N, Shroyer K, Yang J, Ma Y, Crystal RG, Rosengart TK. In vivo cardiac cellular reprogramming efficacy is enhanced by angiogenic preconditioning of the infarcted myocardium with vascular endothelial growth factor. J Am Heart Assoc. 2012 Dec; 1(6):e005652. PMID: 23316332.
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    10. Robinson KA, Li J, Mathison M, Redkar A, Cui J, Chronos NA, Matheny RG, Badylak SF. Extracellular matrix scaffold for cardiac repair. Circulation. 2005 Aug 30; 112(9 Suppl):I135-43. PMID: 16159805.
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    11. Cui J, Li J, Mathison M, Tondato F, Mulkey SP, Micko C, Chronos NA, Robinson KA. A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials. Cardiovasc Revasc Med. 2005 Jul-Sep; 6(3):113-20. PMID: 16275607.
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    12. Mathison MN, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Lima MM. Implications of problematic access in transluminal endografting of abdominal aortic aneurysm. J Vasc Interv Radiol. 2003 Jan; 14(1):33-9. PMID: 12525584.
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    13. Becker GJ, Kovacs M, Mathison MN. Transluminal repair of abdominal aortic aneurysm: a call for selective use, careful surveillance, new device design, and systematic study of transrenal fixation. J Vasc Surg. 2002 Mar; 35(3):611-5. PMID: 11877718.
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    14. Dewey TM, Magee MJ, Edgerton JR, Mathison M, Tennison D, Mack MJ. Off-pump bypass grafting is safe in patients with left main coronary disease. Ann Thorac Surg. 2001 Sep; 72(3):788-91; discussion 792. PMID: 11565659.
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    15. Becker GJ, Kovacs M, Mathison MN, Katzen BT, Benenati JF, Zemel G, Powell A, Almeida JI, Alvarez J, Coello AA, Ingegno MD, Kanter SR, Katzman HE, Puente OA, Reiss IM, Rua I, Gordon R, Baquero J. Risk stratification and outcomes of transluminal endografting for abdominal aortic aneurysm: 7-year experience and long-term follow-up. J Vasc Interv Radiol. 2001 Sep; 12(9):1033-46. PMID: 11535765.
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    16. Mathison M, Becker GJ, Katzen BT, Benenati JF, Zemel G, Powell A, Kovacs ME, Lima MM. The influence of female gender on the outcome of endovascular abdominal aortic aneurysm repair. J Vasc Interv Radiol. 2001 Sep; 12(9):1047-51. PMID: 11535766.
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    17. Mathison M, Edgerton JR, Horswell JL, Akin JJ, Mack MJ. Analysis of hemodynamic changes during beating heart surgical procedures. Ann Thorac Surg. 2000 Oct; 70(4):1355-60; discussion 1360-1. PMID: 11081898.
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    18. Mathison M, Buffolo E, Jatene AD, Jatene FB, Reichenspurner H, Matheny RG, Shennib H, Akin JJ, Mack MJ. Right heart circulatory support facilities coronary artery bypass without cardiopulmonary bypass. Ann Thorac Surg. 2000 Sep; 70(3):1083-5. PMID: 11016382.
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    19. Ide H, Sato M, Fujiki T, Tonari K, Mathison M, Sudo K. [Two cases of surgical treatment of recrudescent Stanford type A dissection after early thrombogenic closure without intimal tear]. Jpn J Thorac Cardiovasc Surg. 1998 Jan; 46(1):85-90. PMID: 9513531.
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    20. Egami J, Fujiki T, Sudo K, Koisizawa T, Mathison M, Kokubo J, Sasagawa N, Honda K, Ide H, Ikeda K. Aneurysm of a branch of the subclavian artery with multiple arteriovenous fistulae. J Cardiovasc Surg (Torino). 1996 Aug; 37(4):355-7. PMID: 8698779.
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    21. Mathison M, Whitfield C, Haydock DA, Kerr AR. Risk factors in heart transplantation. A statistical study of New Zealand cases. Jpn Heart J. 1996 Mar; 37(2):243-9. PMID: 8676551.
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    22. Sekiguchi A, Matsunaga H, Kotsuka Y, Yagyu K, Mathison M, Morizuki O, Ono M, Furuse A. [A role of valvuloplasty in surgical treatment of isolated tricuspid regurgitation]. Kyobu Geka. 1993 Aug; 46(9):751-5. PMID: 8361098.
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    23. Takeshita M, Mathison M, Yagyu K, Kotsuka Y, Matsunaga H, Furuse A. [Congenital bicuspid aortic valve: stenotic type and insufficient type]. J Cardiol Suppl. 1992; 28:133-7; discussion 138. PMID: 1418872.
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    24. Mathison M, Furuse A, Kotsuda H, Tanaka O, Chikada M. [Quadricuspid aortic valve: case reports]. Kyobu Geka. 1990 May; 43(5):383-8. PMID: 2374316.
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    25. Kawauchi M, Yazaki Y, Oka T, Okabe H, Mathison M, Nakajima J, Morizuki O, Kawaguchi G, Koseni K, Takeda M, et al. Diagnosis of cardiac allograft rejection by the detection of circulating plasma cardiac myosin light chains. Jpn J Surg. 1990 Mar; 20(2):212-6. PMID: 2342239.
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    26. Nakajima J, Shindo G, Makuuchi H, Mathison M, Tanaka K, Deguchi J, Furuse A, Kobori O. [Successful resection of mediastinal and abdominal recurrent tumors of esophageal leiomyosarcoma 12 years after surgery]. Kyobu Geka. 1990 Feb; 43(2):102-5. PMID: 2137887.
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    27. Mathison M. Atherosclerosis and blood flow velocity. J Thorac Cardiovasc Surg. 1989 Aug; 98(2):301-2. PMID: 2755166.
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    28. Mathison M, Furuse A, Asano K. Doppler analysis of flow velocity profile at the aortic root. J Am Coll Cardiol. 1988 Oct; 12(4):947-54. PMID: 2971085.
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    29. Atsumi N, Itoh K, Ohokawa Y, Nagata N, Mathison M, Kawataki M, Yasui S, Miyazawa Y, Takarada M. [Clinical study on cardiac pacing in infants and children]. Kyobu Geka. 1987 Aug; 40(9):697-702. PMID: 3682472.
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