TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Radiation Oncology
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    Other Positions
    TitleAssociate Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Medicine

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    R56AR077445     (GHEBRE, YOHANNES T)Sep 10, 2020 - Aug 31, 2021
    Repurposing esomeprazole for the treatment of scleroderma
    Role: Principal Investigator

    R01HL137703     (GHEBRE, YOHANNES T)Jun 1, 2017 - May 31, 2022
    Combination of PPI and pirfenidone to enhance antifibrotic efficacy
    Role: Principal Investigator

    K01HL118683     (GHEBRE, YOHANNES T)Sep 26, 2013 - Feb 29, 2020
    DDAH As a Novel Target in Pulmonary Fibrosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Smith CA, Ebrahimpour A, Novikova L, Farina D, Bailey AO, Russell WK, Jain A, Saltzman AB, Malovannaya A, Prasad BVV, Hu L, Ghebre YT. Esomeprazole covalently interacts with the cardiovascular enzyme dimethylarginine dimethylaminohydrolase: Insights into the cardiovascular risk of proton pump inhibitors. Biochim Biophys Acta Gen Subj. 2022 08; 1866(8):130149. PMID: 35472493.
      Citations:    Fields:    Translation:Humans
    2. Dubey S, Dubey PK, Umeshappa CS, Ghebre YT, Krishnamurthy P. Inhibition of RUNX1 blocks the differentiation of lung fibroblasts to myofibroblasts. J Cell Physiol. 2022 04; 237(4):2169-2182. PMID: 35048404.
      Citations:    Fields:    Translation:AnimalsCells
    3. Hebert KA, Jaramillo S, Yu W, Wang M, Veeramachaneni R, Sandulache VC, Sikora AG, Bonnen MD, Annapragada AV, Corry D, Kheradmand F, Pandita RK, Ludwig MS, Pandita TK, Huang S, Coarfa C, Grimm SL, Perera D, Miles G, Ghebre YT. Esomeprazole enhances the effect of ionizing radiation to improve tumor control. Oncotarget. 2021 Jul 06; 12(14):1339-1353. PMID: 34262645.
      Citations:    Fields:    
    4. Ebrahimpour A, Wang M, Li L, Jegga AG, Bonnen MD, Eissa NT, Raghu G, Jyothula S, Kheradmand F, Hanania NA, Rosas IO, Ghebre YT. Esomeprazole attenuates inflammatory and fibrotic response in lung cells through the MAPK/Nrf2/HO1 pathway. J Inflamm (Lond). 2021 May 19; 18(1):17. PMID: 34011367.
      Citations: 3     
    5. Ghebre YT. Proton Pump Inhibitors and Osteoporosis: Is Collagen a Direct Target? Front Endocrinol (Lausanne). 2020; 11:473. PMID: 32793122.
      Citations: 1     Fields:    Translation:Humans
    6. Pham N, Ludwig MS, Wang M, Ebrahimpour A, Bonnen MD, Diwan AH, Kim SJ, Bryan J, Newton JM, Sikora AG, Donovan DT, Sandulache V, Ghebre YT. Topical Esomeprazole Mitigates Radiation-Induced Dermal Inflammation and Fibrosis. Radiat Res. 2019 11; 192(5):473-482. PMID: 31415221.
      Citations: 6     Fields:    Translation:HumansAnimals
    7. Hanania AN, Mainwaring W, Ghebre YT, Hanania NA, Ludwig M. Radiation-Induced Lung Injury: Assessment and Management. Chest. 2019 07; 156(1):150-162. PMID: 30998908.
      Citations: 105     Fields:    Translation:HumansPHPublic Health
    8. Ebrahimpour A, Shrestha S, Bonnen MD, Eissa NT, Raghu G, Ghebre YT. Nicotine Modulates Growth Factors and MicroRNA to Promote Inflammatory and Fibrotic Processes. J Pharmacol Exp Ther. 2019 02; 368(2):169-178. PMID: 30446578.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    9. Li L, Mok H, Jhaveri P, Bonnen MD, Sikora AG, Eissa NT, Komaki RU, Ghebre YT. Anticancer therapy and lung injury: molecular mechanisms. Expert Rev Anticancer Ther. 2018 10; 18(10):1041-1057. PMID: 29996062.
      Citations: 4     Fields:    Translation:HumansAnimals
    10. Pham N, Bonnen MD, Ghebre YT. Silent Neoplastic Cardiac Invasion in Small Cell Lung Cancer: A Case Report and Review of the Literature. Am J Case Rep. 2018 May 30; 19:619-622. PMID: 29844305.
      Citations: 1     Fields:    Translation:Humans
    11. Ghebre YT. Proton Pump Inhibitors in IPF: A Call for Clinical Trials. Front Pharmacol. 2018; 9:499. PMID: 29867501.
      Citations: 4     
    12. Nelson C, Lee J, Ko K, Sikora AG, Bonnen MD, Enkhbaatar P, Ghebre YT. Therapeutic Efficacy of Esomeprazole in Cotton Smoke-Induced Lung Injury Model. Front Pharmacol. 2017; 8:16. PMID: 28184197.
      Citations: 11     
    13. Ghebre Y, Raghu G. Proton pump inhibitors in IPF: beyond mere suppression of gastric acidity. QJM. 2016 Sep; 109(9):577-579. PMID: 27647940.
      Citations: 9     Fields:    Translation:Humans
    14. Ghebre YT, Yakubov E, Wong WT, Krishnamurthy P, Sayed N, Sikora AG, Bonnen MD. Vascular Aging: Implications for Cardiovascular Disease and Therapy. Transl Med (Sunnyvale). 2016 Dec; 6(4). PMID: 28932625.
      Citations: 22     
    15. Ghebre YT. Antacid therapy and disease outcomes in idiopathic pulmonary fibrosis: flip side of the story. Inflamm Cell Signal. 2016; 3(3). PMID: 29302606.
      Citations: 2     
    16. Ghebre YT, Raghu G. Idiopathic Pulmonary Fibrosis: Novel Concepts of Proton Pump Inhibitors as Antifibrotic Drugs. Am J Respir Crit Care Med. 2016 Jun 15; 193(12):1345-52. PMID: 27110898.
      Citations: 21     Fields:    Translation:Humans
    17. Yepuri G, Sukhovershin R, Nazari-Shafti TZ, Petrascheck M, Ghebre YT, Cooke JP. Proton Pump Inhibitors Accelerate Endothelial Senescence. Circ Res. 2016 06 10; 118(12):e36-42. PMID: 27166251.
      Citations: 37     Fields:    Translation:HumansCells
    18. Zhou G, Meng S, Li Y, Ghebre YT, Cooke JP. Optimal ROS Signaling Is Critical for Nuclear Reprogramming. Cell Rep. 2016 05 03; 15(5):919-925. PMID: 27117405.
      Citations: 46     Fields:    Translation:AnimalsCells
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