EDWARD WEINMAN

TitleClinical Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
Address
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Research 
    Collapse research activities and funding
    R01DK037319     (WEINMAN, EDWARD J)Apr 1, 1987 - Sep 29, 1996
    NIH/NIDDK
    SODIUM/HYDROGEN ION TRANSPORT IN RENAL APICAL MEMBRANES
    Role: Principal Investigator

    R01DK055881     (WEINMAN, EDWARD J)May 1, 1999 - Jun 30, 2014
    NIH/NIDDK
    NHERF-1 and PTH regulation of the renal transport of phosphate.
    Role: Principal Investigator

    I01BX000103     (WEINMAN, EDWARD J)Oct 1, 2009 - Mar 31, 2014
    VA
    NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ. Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging. Life Sci. 2020 Feb 15; 243:117226. PMID: 31904366.
      Citations:    Fields:    Translation:Animals
    2. Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle. FASEB J. 2019 08; 33(8):9008-9016. PMID: 31042404.
      Citations: 1     Fields:    Translation:HumansCells
    3. Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ. Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats. . 2017 Aug 01; 313(2):C197-C206. PMID: 28515088.
      Citations:    
    4. Ritter-Makinson SL, Paquet M, Bogenpohl JW, Rodin RE, Chris Yun C, Weinman EJ, Smith Y, Hall RA. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience. 2017 06 14; 353:58-75. PMID: 28392297.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    5. Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 62(4):1227-36. PMID: 26108984.
      Citations: 6     Fields:    Translation:Animals
    6. He P, Zhao L, Zhu L, Weinman EJ, De Giorgio R, Koval M, Srinivasan S, Yun CC. Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest. 2015 Sep; 125(9):3519-31. PMID: 26258413.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    7. Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED. Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F109-19. PMID: 25995109.
      Citations: 5     Fields:    Translation:AnimalsCells
    8. Giral H, Cranston D, Lanzano L, Caldas Y, Sutherland E, Rachelson J, Dobrinskikh E, Weinman EJ, Doctor RB, Gratton E, Levi M. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem. 2012 Oct 12; 287(42):35047-56. PMID: 22904329.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    9. Weinman EJ, Lederer ED. NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F321-7. PMID: 22535796.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    10. Cardone RA, Greco MR, Capulli M, Weinman EJ, Busco G, Bellizzi A, Casavola V, Antelmi E, Ambruosi B, Dell'Aquila ME, Paradiso A, Teti A, Rucci N, Reshkin SJ. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell. 2012 Jun; 23(11):2028-40. PMID: 22496422.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Weinman EJ, Steplock D, Shenolikar S, Biswas R. Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. J Biol Chem. 2011 Oct 28; 286(43):37216-21. PMID: 21908609.
      Citations: 16     Fields:    Translation:AnimalsCells
    12. Blaine J, Weinman EJ, Cunningham R. The regulation of renal phosphate transport. Adv Chronic Kidney Dis. 2011 Mar; 18(2):77-84. PMID: 21406291.
      Citations: 13     Fields:    Translation:HumansCells
    13. Salyer S, Lesousky N, Weinman EJ, Clark BJ, Lederer ED, Khundmiri SJ. Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells. . 2011 Mar; 300(3):C425-34. PMID: 21160026.
      Citations:    
    14. Evan AP, Weinman EJ, Wu XR, Lingeman JE, Worcester EM, Coe FL. Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice. Urol Res. 2010 Dec; 38(6):439-52. PMID: 21063698.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Weinman EJ, Steplock D, Shenolikar S, Blanpied TA. Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F231-5. PMID: 21048030.
      Citations: 10     Fields:    Translation:AnimalsCells
    16. Cunningham R, Biswas R, Steplock D, Shenolikar S, Weinman E. Role of NHERF and scaffolding proteins in proximal tubule transport. Urol Res. 2010 Aug; 38(4):257-62. PMID: 20632170.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    17. Weinman EJ, Steplock D, Zhang Y, Biswas R, Bloch RJ, Shenolikar S. Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. J Biol Chem. 2010 Aug 13; 285(33):25134-8. PMID: 20571032.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    18. Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci. 2010 Apr 21; 30(16):5617-28. PMID: 20410114.
      Citations: 28     Fields:    Translation:Animals
    19. Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem. 2010 Jun 18; 285(25):19299-307. PMID: 20404332.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    20. Weinman EJ, Biswas R, Steplock D, Douglass TS, Cunningham R, Shenolikar S. Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. J Biol Chem. 2010 Apr 30; 285(18):13454-60. PMID: 20200151.
      Citations: 16     Fields:    Translation:AnimalsCells
    21. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M. PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1560-5. PMID: 19794105.
      Citations: 14     Fields:    Translation:AnimalsCells
    22. Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009 Mar; 119(3):540-50. PMID: 19221439.
      Citations: 39     Fields:    Translation:AnimalsCells
    23. Cunningham R, Esmaili A, Brown E, Biswas RS, Murtazina R, Donowitz M, Dijkman HB, van der Vlag J, Hogema BM, De Jonge HR, Shenolikar S, Wade JB, Weinman EJ. Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F1001-7. PMID: 18256311.
      Citations: 10     Fields:    Translation:Animals
    24. Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED. Novel regulatory function for NHERF-1 in Npt2a transcription. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F840-9. PMID: 18216150.
      Citations: 11     Fields:    Translation:AnimalsCells
    25. Pan Y, Weinman EJ, Dai JL. Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res. 2008; 10(1):R5. PMID: 18190691.
      Citations: 21     Fields:    Translation:AnimalsCells
    26. Weinman EJ, Biswas RS, Peng G, Peng Q, Shen L, Turner CL, E X, Steplock D, Shenolikar S, Cunningham R. Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest. 2007 Nov; 117(11):3412-20. PMID: 17975671.
      Citations: 54     Fields:    Translation:AnimalsCells
    27. Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. J Biol Chem. 2007 Dec 28; 282(52):37575-84. PMID: 17947234.
      Citations: 28     Fields:    Translation:AnimalsCells
    28. Voltz JW, Brush M, Sikes S, Steplock D, Weinman EJ, Shenolikar S. Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. J Biol Chem. 2007 Nov 16; 282(46):33879-87. PMID: 17895247.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    29. Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem. 2007 Aug 24; 282(34):25141-51. PMID: 17580307.
      Citations: 45     Fields:    Translation:Animals
    30. Cunningham R, Brazie M, Kanumuru S, E X, Biswas R, Wang F, Steplock D, Wade JB, Anzai N, Endou H, Shenolikar S, Weinman EJ. Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol. 2007 May; 18(5):1419-25. PMID: 17409311.
      Citations: 13     Fields:    Translation:AnimalsCells
    31. Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell. 2007 May; 18(5):1768-80. PMID: 17332506.
      Citations: 57     Fields:    Translation:HumansCells
    32. Capuano P, Bacic D, Roos M, Gisler SM, Stange G, Biber J, Kaissling B, Weinman EJ, Shenolikar S, Wagner CA, Murer H. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. . 2007 Feb; 292(2):C927-34. PMID: 16987995.
      Citations:    
    33. Cunningham R, Steplock D, E X, Biswas RS, Wang F, Shenolikar S, Weinman EJ. Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F896-901. PMID: 16705152.
      Citations: 14     Fields:    Translation:AnimalsCells
    34. Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annu Rev Physiol. 2006; 68:491-505. PMID: 16460281.
      Citations: 90     Fields:    Translation:HumansAnimals
    35. Weinman EJ, Mohanlal V, Stoycheff N, Wang F, Steplock D, Shenolikar S, Cunningham R. Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F838-43. PMID: 16249272.
      Citations: 15     Fields:    Translation:Animals
    36. Guerra L, Fanelli T, Favia M, Riccardi SM, Busco G, Cardone RA, Carrabino S, Weinman EJ, Reshkin SJ, Conese M, Casavola V. Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells. J Biol Chem. 2005 Dec 09; 280(49):40925-33. PMID: 16203733.
      Citations: 40     Fields:    Translation:HumansCells
    37. Khundmiri SJ, Weinman EJ, Steplock D, Cole J, Ahmad A, Baumann PD, Barati M, Rane MJ, Lederer E. Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells. J Am Soc Nephrol. 2005 Sep; 16(9):2598-607. PMID: 16000700.
      Citations: 14     Fields:    Translation:AnimalsCells
    38. Wang Y, Cai H, Cebotaru L, Hryciw DH, Weinman EJ, Donowitz M, Guggino SE, Guggino WB. ClC-5: role in endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F850-62. PMID: 15942052.
      Citations: 23     Fields:    Translation:AnimalsCells
    39. Cunningham R, E X, Steplock D, Shenolikar S, Weinman EJ. Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F933-8. PMID: 15942053.
      Citations: 20     Fields:    Translation:AnimalsCells
    40. Weinman EJ, Cunningham R, Wade JB, Shenolikar S. The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. J Physiol. 2005 Aug 15; 567(Pt 1):27-32. PMID: 15932893.
      Citations: 21     Fields:    Translation:HumansAnimals
    41. Weinman EJ, Cunningham R, Shenolikar S. NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. Pflugers Arch. 2005 Jun; 450(3):137-44. PMID: 15742180.
      Citations: 13     Fields:    Translation:AnimalsCells
    42. Shenolikar S, Voltz JW, Cunningham R, Weinman EJ. Regulation of ion transport by the NHERF family of PDZ proteins. Physiology (Bethesda). 2004 Dec; 19:362-9. PMID: 15546854.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    43. Cunningham R, Steplock D, Wang F, Huang H, E X, Shenolikar S, Weinman EJ. Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. J Biol Chem. 2004 Sep 03; 279(36):37815-21. PMID: 15218020.
      Citations: 27     Fields:    Translation:AnimalsCells
    44. Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, Liu-Chen LY. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. J Biol Chem. 2004 Jun 11; 279(24):25002-9. PMID: 15070904.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    45. Boehmer C, Embark HM, Bauer A, Palmada M, Yun CH, Weinman EJ, Endou H, Cohen P, Lahme S, Bichler KH, Lang F. Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B. Biochem Biophys Res Commun. 2004 Jan 23; 313(4):998-1003. PMID: 14706641.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    46. Weinman EJ, Wang Y, Wang F, Greer C, Steplock D, Shenolikar S. A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. Biochemistry. 2003 Nov 04; 42(43):12662-8. PMID: 14580213.
      Citations: 21     Fields:    Translation:AnimalsCells
    47. Weinman EJ, Boddeti A, Cunningham R, Akom M, Wang F, Wang Y, Liu J, Steplock D, Shenolikar S, Wade JB. NHERF-1 is required for renal adaptation to a low-phosphate diet. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1225-32. PMID: 12952857.
      Citations: 19     Fields:    Translation:Animals
    48. Sneddon WB, Syme CA, Bisello A, Magyar CE, Rochdi MD, Parent JL, Weinman EJ, Abou-Samra AB, Friedman PA. Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem. 2003 Oct 31; 278(44):43787-96. PMID: 12920119.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    49. Wade JB, Liu J, Coleman RA, Cunningham R, Steplock DA, Lee-Kwon W, Pallone TL, Shenolikar S, Weinman EJ. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. . 2003 Dec; 285(6):C1494-503. PMID: 12917102.
      Citations:    
    50. Lederer ED, Khundmiri SJ, Weinman EJ. Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol. 2003 Jul; 14(7):1711-9. PMID: 12819230.
      Citations: 17     Fields:    Translation:AnimalsCells
    51. Khadeer MA, Tang Z, Tenenhouse HS, Eiden MV, Murer H, Hernando N, Weinman EJ, Chellaiah MA, Gupta A. Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions. . 2003 Jun; 284(6):C1633-44. PMID: 12606316.
      Citations:    
    52. Weinman EJ, Steplock D, Shenolikar S. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett. 2003 Feb 11; 536(1-3):141-4. PMID: 12586353.
      Citations: 26     Fields:    Translation:AnimalsCells
    53. Hernando N, DĂ©liot N, Gisler SM, Lederer E, Weinman EJ, Biber J, Murer H. PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11957-62. PMID: 12192091.
      Citations: 52     Fields:    Translation:AnimalsCells
    WEINMAN's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (278)
    Explore
    _
    Co-Authors (2)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _