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EDWARD WEINMAN

TitleClinical Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    I01BX000103     (WEINMAN, EDWARD J)Oct 1, 2009 - Mar 31, 2014
    VA
    NHERF-1 and dopamine-mediated regulation of renal phosphate transport.
    Role: Principal Investigator
    R01DK055881     (WEINMAN, EDWARD J)May 1, 1999 - Jun 30, 2014
    NIH/NIDDK
    NHERF-1 and PTH regulation of the renal transport of phosphate.
    Role: Principal Investigator
    R01DK037319     (WEINMAN, EDWARD J)Apr 1, 1987 - Sep 29, 1996
    NIH/NIDDK
    SODIUM/HYDROGEN ION TRANSPORT IN RENAL APICAL MEMBRANES
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pushpakumar S, Ahmad A, Ketchem CJ, Jose PA, Weinman EJ, Sen U, Lederer ED, Khundmiri SJ. Sodium-hydrogen exchanger regulatory factor-1 (NHERF1) confers salt sensitivity in both male and female models of hypertension in aging. Life Sci. 2020 Feb 15; 243:117226. PMID: 31904366; PMCID: PMC7015806.
      Citations: 2     Fields:    Translation:Animals
    2. Pera T, Tompkins E, Katz M, Wang B, Deshpande DA, Weinman EJ, Penn RB. Specificity of NHERF1 regulation of GPCR signaling and function in human airway smooth muscle. FASEB J. 2019 08; 33(8):9008-9016. PMID: 31042404; PMCID: PMC6662985.
      Citations: 6     Fields:    Translation:HumansCells
    3. Barati MT, Ketchem CJ, Merchant ML, Kusiak WB, Jose PA, Weinman EJ, LeBlanc AJ, Lederer ED, Khundmiri SJ. Loss of NHERF-1 expression prevents dopamine-mediated Na-K-ATPase regulation in renal proximal tubule cells from rat models of hypertension: aged F344 rats and spontaneously hypertensive rats. Am J Physiol Cell Physiol. 2017 Aug 01; 313(2):C197-C206. PMID: 28515088; PMCID: PMC5582877.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    4. Ritter-Makinson SL, Paquet M, Bogenpohl JW, Rodin RE, Chris Yun C, Weinman EJ, Smith Y, Hall RA. Group II metabotropic glutamate receptor interactions with NHERF scaffold proteins: Implications for receptor localization in brain. Neuroscience. 2017 06 14; 353:58-75. PMID: 28392297; PMCID: PMC5503475.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Li M, Mennone A, Soroka CJ, Hagey LR, Ouyang X, Weinman EJ, Boyer JL. Na(+) /H(+) exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology. 2015 Oct; 62(4):1227-36. PMID: 26108984; PMCID: PMC4589453.
      Citations: 10     Fields:    Translation:Animals
    6. He P, Zhao L, Zhu L, Weinman EJ, De Giorgio R, Koval M, Srinivasan S, Yun CC. Restoration of Na+/H+ exchanger NHE3-containing macrocomplexes ameliorates diabetes-associated fluid loss. J Clin Invest. 2015 Sep; 125(9):3519-31. PMID: 26258413; PMCID: PMC4588303.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    7. Ketchem CJ, Khundmiri SJ, Gaweda AE, Murray R, Clark BJ, Weinman EJ, Lederer ED. Role of Na+/H+ exchanger regulatory factor 1 in forward trafficking of the type IIa Na+-Pi cotransporter. Am J Physiol Renal Physiol. 2015 Jul 15; 309(2):F109-19. PMID: 25995109; PMCID: PMC4504931.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Giral H, Cranston D, Lanzano L, Caldas Y, Sutherland E, Rachelson J, Dobrinskikh E, Weinman EJ, Doctor RB, Gratton E, Levi M. NHE3 regulatory factor 1 (NHERF1) modulates intestinal sodium-dependent phosphate transporter (NaPi-2b) expression in apical microvilli. J Biol Chem. 2012 Oct 12; 287(42):35047-35056. PMID: 22904329; PMCID: PMC3471691.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    9. Weinman EJ, Lederer ED. NHERF-1 and the regulation of renal phosphate reabsoption: a tale of three hormones. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F321-7. PMID: 22535796; PMCID: PMC3433861.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    10. Cardone RA, Greco MR, Capulli M, Weinman EJ, Busco G, Bellizzi A, Casavola V, Antelmi E, Ambruosi B, Dell'Aquila ME, Paradiso A, Teti A, Rucci N, Reshkin SJ. NHERF1 acts as a molecular switch to program metastatic behavior and organotropism via its PDZ domains. Mol Biol Cell. 2012 Jun; 23(11):2028-40. PMID: 22496422; PMCID: PMC3364169.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    11. Weinman EJ, Steplock D, Shenolikar S, Biswas R. Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. J Biol Chem. 2011 Oct 28; 286(43):37216-21. PMID: 21908609; PMCID: PMC3199469.
      Citations: 23     Fields:    Translation:AnimalsCells
    12. Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X. Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics. 2011 Jun 15; 43(11):674-84. PMID: 21427361; PMCID: PMC3121161.
      Citations:    
    13. Blaine J, Weinman EJ, Cunningham R. The regulation of renal phosphate transport. Adv Chronic Kidney Dis. 2011 Mar; 18(2):77-84. PMID: 21406291.
      Citations: 16     Fields:    Translation:HumansCells
    14. Salyer S, Lesousky N, Weinman EJ, Clark BJ, Lederer ED, Khundmiri SJ. Dopamine regulation of Na+-K+-ATPase requires the PDZ-2 domain of sodium hydrogen regulatory factor-1 (NHERF-1) in opossum kidney cells. Am J Physiol Cell Physiol. 2011 Mar; 300(3):C425-34. PMID: 21160026; PMCID: PMC3063973.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    15. Evan AP, Weinman EJ, Wu XR, Lingeman JE, Worcester EM, Coe FL. Comparison of the pathology of interstitial plaque in human ICSF stone patients to NHERF-1 and THP-null mice. Urol Res. 2010 Dec; 38(6):439-52. PMID: 21063698; PMCID: PMC3035321.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    16. Weinman EJ, Steplock D, Shenolikar S, Blanpied TA. Dynamics of PTH-induced disassembly of Npt2a/NHERF-1 complexes in living OK cells. Am J Physiol Renal Physiol. 2011 Jan; 300(1):F231-5. PMID: 21048030; PMCID: PMC3023216.
      Citations: 14     Fields:    Translation:AnimalsCells
    17. Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics. 2010 Nov 15; 42A(3):200-10. PMID: 20736413; PMCID: PMC3008364.
      Citations:    
    18. Cunningham R, Biswas R, Steplock D, Shenolikar S, Weinman E. Role of NHERF and scaffolding proteins in proximal tubule transport. Urol Res. 2010 Aug; 38(4):257-62. PMID: 20632170.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    19. Weinman EJ, Steplock D, Zhang Y, Biswas R, Bloch RJ, Shenolikar S. Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. J Biol Chem. 2010 Aug 13; 285(33):25134-8. PMID: 20571032; PMCID: PMC2919075.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    20. Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci. 2010 Apr 21; 30(16):5617-28. PMID: 20410114; PMCID: PMC2865237.
      Citations: 35     Fields:    Translation:Animals
    21. Li M, Wang W, Soroka CJ, Mennone A, Harry K, Weinman EJ, Boyer JL. NHERF-1 binds to Mrp2 and regulates hepatic Mrp2 expression and function. J Biol Chem. 2010 Jun 18; 285(25):19299-307. PMID: 20404332; PMCID: PMC2885208.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    22. Weinman EJ, Biswas R, Steplock D, Douglass TS, Cunningham R, Shenolikar S. Sodium-hydrogen exchanger regulatory factor 1 (NHERF-1) transduces signals that mediate dopamine inhibition of sodium-phosphate co-transport in mouse kidney. J Biol Chem. 2010 Apr 30; 285(18):13454-60. PMID: 20200151; PMCID: PMC2859505.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Weinman EJ, Steplock D, Cha B, Kovbasnjuk O, Frost NA, Cunningham R, Shenolikar S, Blanpied TA, Donowitz M. PTH transiently increases the percent mobile fraction of Npt2a in OK cells as determined by FRAP. Am J Physiol Renal Physiol. 2009 Dec; 297(6):F1560-5. PMID: 19794105; PMCID: PMC2801338.
      Citations: 17     Fields:    Translation:AnimalsCells
    24. Singh AK, Riederer B, Rausch B, Bonhagen J, Lehmann U, de Jonge HR, Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U, Krabbenh?ft A. Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest. 2009 Mar; 119(3):540-50. PMID: 19221439; PMCID: PMC2648694.
      Citations: 44     Fields:    Translation:AnimalsCells
    25. Broere N, Chen M, Cinar A, Singh AK, Hillesheim J, Riederer B, Lünnemann M, Rottinghaus I, Krabbenhöft A, Engelhardt R, Rausch B, Weinman EJ, Donowitz M, Hubbard A, Kocher O, de Jonge HR, Hogema BM, Seidler U, L?nnemann M, Krabbenh?ft A. Defective jejunal and colonic salt absorption and alteredNa(+)/H (+) exchanger 3 (NHE3) activity in NHE regulatory factor 1 (NHERF1) adaptor protein-deficient mice. Pflugers Arch. 2009 Mar; 457(5):1079-91. PMID: 18758809; PMCID: PMC3746809.
      Citations:    
    26. Cunningham R, Esmaili A, Brown E, Biswas RS, Murtazina R, Donowitz M, Dijkman HB, van der Vlag J, Hogema BM, De Jonge HR, Shenolikar S, Wade JB, Weinman EJ. Urine electrolyte, mineral, and protein excretion in NHERF-2 and NHERF-1 null mice. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F1001-7. PMID: 18256311.
      Citations: 12     Fields:    Translation:Animals
    27. Khundmiri SJ, Ahmad A, Bennett RE, Weinman EJ, Steplock D, Cole J, Baumann PD, Lewis J, Singh S, Clark BJ, Lederer ED. Novel regulatory function for NHERF-1 in Npt2a transcription. Am J Physiol Renal Physiol. 2008 Apr; 294(4):F840-9. PMID: 18216150.
      Citations: 14     Fields:    Translation:AnimalsCells
    28. Pan Y, Weinman EJ, Dai JL. Na+/H+ exchanger regulatory factor 1 inhibits platelet-derived growth factor signaling in breast cancer cells. Breast Cancer Res. 2008; 10(1):R5. PMID: 18190691; PMCID: PMC2374956.
      Citations: 24     Fields:    Translation:AnimalsCells
    29. Weinman EJ, Biswas RS, Peng G, Peng Q, Shen L, Turner CL, E X, Steplock D, Shenolikar S, Cunningham R. Parathyroid hormone inhibits renal phosphate transport by phosphorylation of serine 77 of sodium-hydrogen exchanger regulatory factor-1. J Clin Invest. 2007 Nov; 117(11):3412-20. PMID: 17975671; PMCID: PMC2045615.
      Citations: 63     Fields:    Translation:AnimalsCells
    30. Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. J Biol Chem. 2007 Dec 28; 282(52):37575-84. PMID: 17947234.
      Citations: 28     Fields:    Translation:AnimalsCells
    31. Voltz JW, Brush M, Sikes S, Steplock D, Weinman EJ, Shenolikar S. Phosphorylation of PDZ1 domain attenuates NHERF-1 binding to cellular targets. J Biol Chem. 2007 Nov 16; 282(46):33879-33887. PMID: 17895247.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    32. Murtazina R, Kovbasnjuk O, Zachos NC, Li X, Chen Y, Hubbard A, Hogema BM, Steplock D, Seidler U, Hoque KM, Tse CM, De Jonge HR, Weinman EJ, Donowitz M. Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum versus proximal tubule. J Biol Chem. 2007 Aug 24; 282(34):25141-51. PMID: 17580307.
      Citations: 50     Fields:    Translation:Animals
    33. Cunningham R, Brazie M, Kanumuru S, E X, Biswas R, Wang F, Steplock D, Wade JB, Anzai N, Endou H, Shenolikar S, Weinman EJ. Sodium-hydrogen exchanger regulatory factor-1 interacts with mouse urate transporter 1 to regulate renal proximal tubule uric acid transport. J Am Soc Nephrol. 2007 May; 18(5):1419-25. PMID: 17409311.
      Citations: 16     Fields:    Translation:AnimalsCells
    34. Cardone RA, Bellizzi A, Busco G, Weinman EJ, Dell'Aquila ME, Casavola V, Azzariti A, Mangia A, Paradiso A, Reshkin SJ. The NHERF1 PDZ2 domain regulates PKA-RhoA-p38-mediated NHE1 activation and invasion in breast tumor cells. Mol Biol Cell. 2007 May; 18(5):1768-80. PMID: 17332506; PMCID: PMC1855021.
      Citations: 70     Fields:    Translation:HumansCells
    35. Capuano P, Bacic D, Roos M, Gisler SM, Stange G, Kaissling B, Weinman EJ, Shenolikar S, Wagner CA, Murer H, Biber J. Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. Am J Physiol Cell Physiol. 2007 Feb; 292(2):C927-34. PMID: 16987995.
      Citations: 32     Fields:    Translation:AnimalsCells
    36. Cunningham R, Steplock D, E X, Biswas RS, Wang F, Shenolikar S, Weinman EJ. Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F896-901. PMID: 16705152.
      Citations: 16     Fields:    Translation:AnimalsCells
    37. Weinman EJ, Hall RA, Friedman PA, Liu-Chen LY, Shenolikar S. The association of NHERF adaptor proteins with g protein-coupled receptors and receptor tyrosine kinases. Annu Rev Physiol. 2006; 68:491-505. PMID: 16460281.
      Citations: 99     Fields:    Translation:HumansAnimals
    38. Weinman EJ, Mohanlal V, Stoycheff N, Wang F, Steplock D, Shenolikar S, Cunningham R. Longitudinal study of urinary excretion of phosphate, calcium, and uric acid in mutant NHERF-1 null mice. Am J Physiol Renal Physiol. 2006 Apr; 290(4):F838-43. PMID: 16249272.
      Citations: 18     Fields:    Translation:Animals
    39. Guerra L, Fanelli T, Favia M, Riccardi SM, Busco G, Cardone RA, Carrabino S, Weinman EJ, Reshkin SJ, Conese M, Casavola V. Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells. J Biol Chem. 2005 Dec 09; 280(49):40925-33. PMID: 16203733.
      Citations: 44     Fields:    Translation:HumansCells
    40. Khundmiri SJ, Weinman EJ, Steplock D, Cole J, Ahmad A, Baumann PD, Barati M, Rane MJ, Lederer E. Parathyroid hormone regulation of NA+,K+-ATPase requires the PDZ 1 domain of sodium hydrogen exchanger regulatory factor-1 in opossum kidney cells. J Am Soc Nephrol. 2005 Sep; 16(9):2598-607. PMID: 16000700.
      Citations: 21     Fields:    Translation:AnimalsCells
    41. Wang Y, Cai H, Cebotaru L, Hryciw DH, Weinman EJ, Donowitz M, Guggino SE, Guggino WB. ClC-5: role in endocytosis in the proximal tubule. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F850-62. PMID: 15942052.
      Citations: 24     Fields:    Translation:AnimalsCells
    42. Cunningham R, E X, Steplock D, Shenolikar S, Weinman EJ. Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. Am J Physiol Renal Physiol. 2005 Oct; 289(4):F933-8. PMID: 15942053.
      Citations: 26     Fields:    Translation:AnimalsCells
    43. Weinman EJ, Cunningham R, Wade JB, Shenolikar S. The role of NHERF-1 in the regulation of renal proximal tubule sodium-hydrogen exchanger 3 and sodium-dependent phosphate cotransporter 2a. J Physiol. 2005 Aug 15; 567(Pt 1):27-32. PMID: 15932893; PMCID: PMC1474161.
      Citations: 24     Fields:    Translation:HumansAnimals
    44. Weinman EJ, Cunningham R, Shenolikar S. NHERF and regulation of the renal sodium-hydrogen exchanger NHE3. Pflugers Arch. 2005 Jun; 450(3):137-44. PMID: 15742180.
      Citations: 16     Fields:    Translation:AnimalsCells
    45. Shenolikar S, Voltz JW, Cunningham R, Weinman EJ. Regulation of ion transport by the NHERF family of PDZ proteins. Physiology (Bethesda). 2004 Dec; 19:362-9. PMID: 15546854.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    46. Cunningham R, Steplock D, Wang F, Huang H, E X, Shenolikar S, Weinman EJ. Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. J Biol Chem. 2004 Sep 03; 279(36):37815-21. PMID: 15218020.
      Citations: 28     Fields:    Translation:AnimalsCells
    47. Huang P, Steplock D, Weinman EJ, Hall RA, Ding Z, Li J, Wang Y, Liu-Chen LY. kappa Opioid receptor interacts with Na(+)/H(+)-exchanger regulatory factor-1/Ezrin-radixin-moesin-binding phosphoprotein-50 (NHERF-1/EBP50) to stimulate Na(+)/H(+) exchange independent of G(i)/G(o) proteins. J Biol Chem. 2004 Jun 11; 279(24):25002-9. PMID: 15070904.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    48. Embark HM, Bauer A, Palmada M, Yun CH, Weinman EJ, Endou H, Cohen P, Lahme S, Bichler KH, Lang F, Boehmer C. Stimulation of renal Na+ dicarboxylate cotransporter 1 by Na+/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B. Biochem Biophys Res Commun. 2004 Jan 23; 313(4):998-1003. PMID: 14706641.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    49. Weinman EJ, Wang Y, Wang F, Greer C, Steplock D, Shenolikar S. A C-terminal PDZ motif in NHE3 binds NHERF-1 and enhances cAMP inhibition of sodium-hydrogen exchange. Biochemistry. 2003 Nov 04; 42(43):12662-8. PMID: 14580213.
      Citations: 22     Fields:    Translation:AnimalsCells
    50. Weinman EJ, Boddeti A, Cunningham R, Akom M, Wang F, Wang Y, Liu J, Steplock D, Shenolikar S, Wade JB. NHERF-1 is required for renal adaptation to a low-phosphate diet. Am J Physiol Renal Physiol. 2003 Dec; 285(6):F1225-32. PMID: 12952857.
      Citations: 21     Fields:    Translation:Animals
    51. Sneddon WB, Syme CA, Bisello A, Magyar CE, Rochdi MD, Parent JL, Weinman EJ, Abou-Samra AB, Friedman PA. Activation-independent parathyroid hormone receptor internalization is regulated by NHERF1 (EBP50). J Biol Chem. 2003 Oct 31; 278(44):43787-96. PMID: 12920119.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    52. Wade JB, Liu J, Coleman RA, Cunningham R, Steplock DA, Lee-Kwon W, Pallone TL, Shenolikar S, Weinman EJ. Localization and interaction of NHERF isoforms in the renal proximal tubule of the mouse. Am J Physiol Cell Physiol. 2003 Dec; 285(6):C1494-503. PMID: 12917102.
      Citations: 47     Fields:    Translation:AnimalsCells
    53. Lederer ED, Khundmiri SJ, Weinman EJ. Role of NHERF-1 in regulation of the activity of Na-K ATPase and sodium-phosphate co-transport in epithelial cells. J Am Soc Nephrol. 2003 Jul; 14(7):1711-9. PMID: 12819230.
      Citations: 17     Fields:    Translation:AnimalsCells
    54. Khadeer MA, Tang Z, Tenenhouse HS, Eiden MV, Murer H, Hernando N, Weinman EJ, Chellaiah MA, Gupta A. Na+-dependent phosphate transporters in the murine osteoclast: cellular distribution and protein interactions. Am J Physiol Cell Physiol. 2003 Jun; 284(6):C1633-44. PMID: 12606316.
      Citations: 14     Fields:    Translation:AnimalsCells
    55. Weinman EJ, Steplock D, Shenolikar S. NHERF-1 uniquely transduces the cAMP signals that inhibit sodium-hydrogen exchange in mouse renal apical membranes. FEBS Lett. 2003 Feb 11; 536(1-3):141-4. PMID: 12586353.
      Citations: 27     Fields:    Translation:AnimalsCells
    56. Hernando N, Gisler SM, Lederer E, Weinman EJ, Murer H, D?liot N, Biber J. PDZ-domain interactions and apical expression of type IIa Na/P(i) cotransporters. Proc Natl Acad Sci U S A. 2002 Sep 03; 99(18):11957-62. PMID: 12192091; PMCID: PMC129376.
      Citations: 67     Fields:    Translation:AnimalsCells
    57. Shenolikar S, Voltz JW, Minkoff CM, Wade JB, Weinman EJ. Targeted disruption of the mouse NHERF-1 gene promotes internalization of proximal tubule sodium-phosphate cotransporter type IIa and renal phosphate wasting. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11470-5. PMID: 12169661; PMCID: PMC123280.
      Citations: 135     Fields:    Translation:AnimalsCells
    58. Li X, Galli T, Leu S, Wade JB, Weinman EJ, Leung G, Cheong A, Louvard D, Donowitz M. Na+-H+ exchanger 3 (NHE3) is present in lipid rafts in the rabbit ileal brush border: a role for rafts in trafficking and rapid stimulation of NHE3. J Physiol. 2001 Dec 01; 537(Pt 2):537-52. PMID: 11731584; PMCID: PMC2278967.
      Citations: 52     Fields:    Translation:AnimalsCells
    59. Voltz JW, Weinman EJ, Shenolikar S. Expanding the role of NHERF, a PDZ-domain containing protein adapter, to growth regulation. Oncogene. 2001 Oct 01; 20(44):6309-14. PMID: 11607833.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    60. Weinman EJ, Evangelista CM, Steplock D, Liu MZ, Shenolikar S, Bernardo A. Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. J Biol Chem. 2001 Nov 09; 276(45):42339-46. PMID: 11535598.
      Citations: 6     Fields:    Translation:AnimalsCells
    61. Weinman EJ, Steplock D, Wade JB, Shenolikar S. Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. Am J Physiol Renal Physiol. 2001 Aug; 281(2):F374-80. PMID: 11457730.
      Citations: 14     Fields:    Translation:AnimalsCells
    62. Weinman EJ. New functions for the NHERF family of proteins. J Clin Invest. 2001 Jul; 108(2):185-6. PMID: 11457870; PMCID: PMC203032.
      Citations: 7     Fields:    Translation:AnimalsCells
    63. Shenolikar S, Weinman EJ. NHERF: targeting and trafficking membrane proteins. Am J Physiol Renal Physiol. 2001 Mar; 280(3):F389-95. PMID: 11181400.
      Citations: 58     Fields:    Translation:AnimalsCells
    64. Shenolikar S, Minkoff CM, Steplock DA, Evangelista C, Liu M, Weinman EJ. N-terminal PDZ domain is required for NHERF dimerization. FEBS Lett. 2001 Feb 02; 489(2-3):233-6. PMID: 11165256.
      Citations: 30     Fields:    Translation:AnimalsCells
    65. Wade JB, Welling PA, Donowitz M, Shenolikar S, Weinman EJ. Differential renal distribution of NHERF isoforms and their colocalization with NHE3, ezrin, and ROMK. Am J Physiol Cell Physiol. 2001 Jan; 280(1):C192-8. PMID: 11121391.
      Citations: 39     Fields:    Translation:AnimalsCells
    66. Weinman EJ, Minkoff C, Shenolikar S. Signal complex regulation of renal transport proteins: NHERF and regulation of NHE3 by PKA. Am J Physiol Renal Physiol. 2000 Sep; 279(3):F393-9. PMID: 10966919.
      Citations: 25     Fields:    Translation:AnimalsCells
    67. Weinman EJ, Steplock D, Donowitz M, Shenolikar S. NHERF associations with sodium-hydrogen exchanger isoform 3 (NHE3) and ezrin are essential for cAMP-mediated phosphorylation and inhibition of NHE3. Biochemistry. 2000 May 23; 39(20):6123-9. PMID: 10821685.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    68. Weinman EJ, Steplock D, Zhang X, Akhter S, Shenolikar S. Molecular cloning of the cDNA and promoter sequences for the mouse sodium-hydrogen exchanger regulatory factor. Biochim Biophys Acta. 1999 Oct 06; 1447(1):71-6. PMID: 10500246.
      Citations: 5     Fields:    Translation:AnimalsCells
    69. Minkoff C, Shenolikar S, Weinman EJ. Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. Curr Opin Nephrol Hypertens. 1999 Sep; 8(5):603-8. PMID: 10541224.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    70. Zizak M, Lamprecht G, Steplock D, Tariq N, Shenolikar S, Donowitz M, Yun CH, Weinman EJ. cAMP-induced phosphorylation and inhibition of Na(+)/H(+) exchanger 3 (NHE3) are dependent on the presence but not the phosphorylation of NHE regulatory factor. J Biol Chem. 1999 Aug 27; 274(35):24753-8. PMID: 10455146.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    71. Ediger TR, Kraus WL, Weinman EJ, Katzenellenbogen BS. Estrogen receptor regulation of the Na+/H+ exchange regulatory factor. Endocrinology. 1999 Jul; 140(7):2976-82. PMID: 10385389.
      Citations: 41     Fields:    Translation:HumansCells
    72. Bernardo AA, Kear FT, Santos AV, Ma J, Steplock D, Robey RB, Weinman EJ. Basolateral Na(+)/HCO(3)(-) cotransport activity is regulated by the dissociable Na(+)/H(+) exchanger regulatory factor. J Clin Invest. 1999 Jul; 104(2):195-201. PMID: 10411549; PMCID: PMC408472.
      Citations: 8     Fields:    Translation:AnimalsCells
    73. Weinman EJ, Steplock D, Lamprecht G, Yun CH, Shenolikar S. Regulation of the Na/H exchanger regulatory factor in OK cells. Miner Electrolyte Metab. 1999 May-Jun; 25(3):135-42. PMID: 10436398.
      Citations: 2     Fields:    Translation:AnimalsCells
    74. Lamprecht G, Weinman EJ, Yun CH. The role of NHERF and E3KARP in the cAMP-mediated inhibition of NHE3. J Biol Chem. 1998 Nov 06; 273(45):29972-8. PMID: 9792717.
      Citations: 67     Fields:    Translation:AnimalsCells
    75. Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, Shenolikar S. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). J Clin Invest. 1998 May 15; 101(10):2199-206. PMID: 9593775; PMCID: PMC508807.
      Citations: 34     Fields:    Translation:AnimalsCells
    76. Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, Lefkowitz RJ. The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange. Nature. 1998 Apr 09; 392(6676):626-30. PMID: 9560162.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    77. Weinman EJ, Shenolikar S. The Na-H exchanger regulatory factor. Exp Nephrol. 1997 Nov-Dec; 5(6):449-52. PMID: 9438172.
      Citations: 7     Fields:    Translation:HumansAnimals
    78. Yun CH, Oh S, Zizak M, Steplock D, Tsao S, Tse CM, Weinman EJ, Donowitz M. cAMP-mediated inhibition of the epithelial brush border Na+/H+ exchanger, NHE3, requires an associated regulatory protein. Proc Natl Acad Sci U S A. 1997 Apr 01; 94(7):3010-5. PMID: 9096337; PMCID: PMC20313.
      Citations: 154     Fields:    Translation:HumansAnimalsCells
    79. Weinman EJ, Steplock D, Wang Y, Shenolikar S. Characterization of a protein cofactor that mediates protein kinase A regulation of the renal brush border membrane Na(+)-H+ exchanger. J Clin Invest. 1995 May; 95(5):2143-9. PMID: 7738182; PMCID: PMC295815.
      Citations: 94     Fields:    Translation:AnimalsCells
    80. Weinman EJ, Steplock D, Shenolikar S. CAMP-mediated inhibition of the renal brush border membrane Na+-H+ exchanger requires a dissociable phosphoprotein cofactor. J Clin Invest. 1993 Oct; 92(4):1781-6. PMID: 8408631; PMCID: PMC288340.
      Citations: 31     Fields:    Translation:AnimalsCells
    81. Weinman EJ, Steplock D, Corry D, Shenolikar S. Identification of the human NHE-1 form of Na(+)-H+ exchanger in rabbit renal brush border membranes. J Clin Invest. 1993 May; 91(5):2097-102. PMID: 8486777; PMCID: PMC288209.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    82. Weinman EJ, Shenolikar S. Regulation of the renal brush border membrane Na(+)-H+ exchanger. Annu Rev Physiol. 1993; 55:289-304. PMID: 8385434.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    83. Weinman E, Hanley R, Morell G, Yuan N, Steplock D, Bui G, Shenolikar S. Regulation of the renal Na(+)-H+ exchanger by calcium calmodulin-dependent multifunctional protein kinase II. Miner Electrolyte Metab. 1992; 18(1):35-9. PMID: 1328833.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Morell G, Steplock D, Shenolikar S, Weinman EJ. Identification of a putative Na(+)-H+ exchanger regulatory cofactor in rabbit renal BBM. Am J Physiol. 1990 Dec; 259(6 Pt 2):F867-71. PMID: 2175560.
      Citations: 9     Fields:    Translation:AnimalsCells
    85. Weinman EJ, Steplock D, Bui G, Yuan N, Shenolikar S. Regulation of renal Na(+)-H+ exchanger by cAMP-dependent protein kinase. Am J Physiol. 1990 May; 258(5 Pt 2):F1254-8. PMID: 2159717.
      Citations: 12     Fields:    Translation:AnimalsCells
    86. Weinman EJ, Dubinsky W, Shenolikar S. Regulation of the renal Na+-H+ exchanger by protein phosphorylation. Kidney Int. 1989 Oct; 36(4):519-25. PMID: 2554050.
      Citations: 15     Fields:    Translation:HumansCells
    87. Weinman EJ, Dubinsky WP, Dinh Q, Steplock D, Shenolikar S. Effect of limited trypsin digestion on the renal Na+-H+ exchanger and its regulation by cAMP-dependent protein kinase. J Membr Biol. 1989 Aug; 109(3):233-41. PMID: 2552124.
      Citations: 12     Fields:    Translation:AnimalsCells
    88. Weinman EJ, Dubinsky WP, Shenolikar S. Regulation of the renal Na+-H+ exchanger. Hosp Pract (Off Ed). 1989 Mar 15; 24(3):157-61, 164, 167 passim. PMID: 2493468.
      Citations:    Fields:    Translation:HumansAnimalsCells
    89. Weinman EJ, Dubinsky WP, Fisher K, Steplock D, Dinh Q, Chang L, Shenolikar S. Regulation of reconstituted renal Na+/H+ exchanger by calcium-dependent protein kinases. J Membr Biol. 1988 Aug; 103(3):237-44. PMID: 2846848.
      Citations: 15     Fields:    Translation:AnimalsCells
    90. Weinman EJ, Shenolikar S, Cragoe EJ, Dubinsky WP. Solubilization and reconstitution of renal brush border Na+-H+ exchanger. J Membr Biol. 1988; 101(1):1-9. PMID: 2835484.
      Citations: 8     Fields:    Translation:AnimalsCells
    91. Weinman EJ, Dubinsky WP, Shenolikar S. Reconstitution of cAMP-dependent protein kinase regulated renal Na+-H+ exchanger. J Membr Biol. 1988; 101(1):11-8. PMID: 2835485.
      Citations: 18     Fields:    Translation:AnimalsCells
    92. Weinman EJ, Shenolikar S, Kahn AM. cAMP-associated inhibition of Na+-H+ exchanger in rabbit kidney brush-border membranes. Am J Physiol. 1987 Jan; 252(1 Pt 2):F19-25. PMID: 3028154.
      Citations: 28     Fields:    Translation:AnimalsCells
    93. Weinman EJ, Shenolikar S. Protein kinase C activates the renal apical membrane Na+/H+ exchanger. J Membr Biol. 1986; 93(2):133-9. PMID: 3027347.
      Citations: 23     Fields:    Translation:AnimalsCells
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