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DOBROMIR DOBREV

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dobrev D, Lorenz K. Age-dependent increase in c-Jun N-terminal kinase-2 activity: does this help to understand Ca2+-calmodulin-dependent protein-kinase II-mediated atrial arrhythmogenesis in human atrial fibrillation? Cardiovasc Res. 2018 Apr 01; 114(5):641-642. PMID: 29432608.
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    2. Tsuji Y, Dobrev D. Prognostic impact of electrical storm in patients with implantable cardioverter defibrillators: Mechanistic and therapeutic considerations to reduce the risk of death. Int J Cardiol. 2018 Mar 15; 255:101-102. PMID: 29425546.
      View in: PubMed
    3. Heijman J, Guichard JB, Dobrev D, Nattel S. Translational Challenges in Atrial Fibrillation. Circ Res. 2018 Mar 02; 122(5):752-773. PMID: 29496798.
      View in: PubMed
    4. Kotecha D, Breithardt G, Camm AJ, Lip GYH, Schotten U, Ahlsson A, Arnar D, Atar D, Auricchio A, Bax J, Benussi S, Blomstrom-Lundqvist C, Borggrefe M, Boriani G, Brandes A, Calkins H, Casadei B, Castellá M, Chua W, Crijns H, Dobrev D, Fabritz L, Feuring M, Freedman B, Gerth A, Goette A, Guasch E, Haase D, Hatem S, Haeusler KG, Heidbuchel H, Hendriks J, Hunter C, Kääb S, Kespohl S, Landmesser U, Lane DA, Lewalter T, Mont L, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Pison L, Potpara T, Ravens U, Richard-Lordereau I, Rienstra M, Savelieva I, Schnabel R, Sinner MF, Sommer P, Themistoclakis S, Van Gelder IC, Vardas PE, Verma A, Wakili R, Weber E, Werring D, Willems S, Ziegler A, Hindricks G, Kirchhof P. Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference. Europace. 2018 Mar 01; 20(3):395-407. PMID: 29300976.
      View in: PubMed
    5. Molina CE, Jacquet E, Ponien P, Muñoz-Guijosa C, Baczkó I, Maier LS, Donzeau-Gouge P, Dobrev D, Fischmeister R, Garnier A. Identification of optimal reference genes for transcriptomic analyses in normal and diseased human heart. Cardiovasc Res. 2018 Feb 01; 114(2):247-258. PMID: 29036603.
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    6. Li N, Dobrev D. Targeting atrial fibrillation promoting atrial structural remodeling: is this a viable strategy in patients with heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2018 Mar; 391(3):231-233. PMID: 29327256.
      View in: PubMed
    7. Heijman J, Kirchner D, Kunze F, Chrétien EM, Michel-Reher MB, Voigt N, Knaut M, Michel MC, Ravens U, Dobrev D. Muscarinic type-1 receptors contribute to IK,ACh in human atrial cardiomyocytes and are upregulated in patients with chronic atrial fibrillation. Int J Cardiol. 2018 Mar 15; 255:61-68. PMID: 29290419.
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    8. Wakili R, Dobrev D. Response to: "The emerging role of hybrid ablation for ablation" by Spartialis M. et al. Int J Cardiol. 2017 12 15; 249:258. PMID: 29121728.
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    9. Heijman J, Dobrev D. Ion channels as part of macromolecular multiprotein complexes : Clinical significance. Herzschrittmacherther Elektrophysiol. 2018 Mar; 29(1):30-35. PMID: 29214349.
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    10. Grandi E, Dobrev D. Non-ion channel therapeutics for heart failure and atrial fibrillation: Are CaMKII inhibitors ready for clinical use? J Mol Cell Cardiol. 2017 Oct 25. PMID: 29079077.
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    11. Abu-Taha IH, Heijman J, Feng Y, Vettel C, Dobrev D, Wieland T. Regulation of heterotrimeric G-protein signaling by NDPK/NME proteins and caveolins: an update. Lab Invest. 2018 Feb; 98(2):190-197. PMID: 29035382.
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    12. Heijman J, Dobrev D. Inhibition of Small-Conductance Ca2+-Activated K+ Channels: The Long-Awaited Breakthrough for Antiarrhythmic Drug Therapy of Atrial Fibrillation? Circ Arrhythm Electrophysiol. 2017 Oct; 10(10). PMID: 29018167.
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    13. Ellinwood N, Dobrev D, Morotti S, Grandi E. Erratum: "Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity" [Chaos 27, 093918 (2017)]. Chaos. 2017 Oct; 27(10):109902. PMID: 29092428.
      View in: PubMed
    14. Heijman J, Dobrev D, Crijns HJGM. Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation? Int J Cardiol. 2017 Oct 01; 244:202-203. PMID: 28784443.
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    15. Fender AC, Dobrev D. Dynamic balance of platelet reactivity in atrial fibrillation PARtially unravelled. Int J Cardiol. 2017 Sep 15; 243:272-273. PMID: 28747029.
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    16. Wakili R, Dobrev D. Role of triggers and substrate in heart failure based atrial fibrillation: Is pulmonary vein isolation still the cornerstone of atrial fibrillation therapy? Int J Cardiol. 2017 Sep 15; 243:276-278. PMID: 28747031.
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    17. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 Sep; 112(5):51. PMID: 28688054.
      View in: PubMed
    18. Ellinwood N, Dobrev D, Morotti S, Grandi E. Revealing kinetics and state-dependent binding properties of IKur-targeting drugs that maximize atrial fibrillation selectivity. Chaos. 2017 Sep; 27(9):093918. PMID: 28964116.
      View in: PubMed
    19. Heijman J, Ghezelbash S, Dobrev D. Investigational antiarrhythmic agents: promising drugs in early clinical development. Expert Opin Investig Drugs. 2017 Jul 10. PMID: 28691539.
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    20. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175.
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    21. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sosalla ST, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 Jul; 112(4):43. PMID: 28597249.
      View in: PubMed
    22. Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 May 24. PMID: 28542844.
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    23. Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A. Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug; 390(8):857-862. PMID: 28451724.
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    24. Dobrev D, Wehrens XH. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 Feb 09. PMID: 28181690.
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    25. Chen Y, Surinkaew S, Naud P, Qi XY, Gillis MA, Shi YF, Tardif JC, Dobrev D, Nattel S. JAK-STAT signaling and the atrial fibrillation promoting fibrotic substrate. Cardiovasc Res. 2017 Feb 02. PMID: 28158495.
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    26. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 Jan 07. PMID: 28077320.
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    27. Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D. Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 2017 Jan 04. PMID: 28057773.
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    28. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2016 Dec 07. PMID: 27927712.
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    29. Li N, Dobrev D. Hyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation? Int J Cardiol. 2016 Dec 06. PMID: 27993379.
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    30. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2016 Nov 03. PMID: 27808412.
      View in: PubMed
    31. Dobrev D. Unique cardiomyocyte ultrastructure in atria: Role of T tubules in subcellular Ca(2+) signaling and atrial arrhythmogenesis. Heart Rhythm. 2017 Feb; 14(2):282-283. PMID: 27756707.
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    32. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO). Eur J Cardiothorac Surg. 2016 Sep 23. PMID: 27663299.
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    33. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175.
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    34. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Europace. 2016 Nov; 18(11):1609-1678. PMID: 27567465.
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    35. Nattel S, Dobrev D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat Rev Cardiol. 2016 Oct; 13(10):575-90. PMID: 27489190.
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    36. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D?Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. J Arrhythm. 2016 Aug; 32(4):247-78. PMID: 27588148; PMCID: PMC4996910.
    37. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Europace. 2016 Oct; 18(10):1455-1490. PMID: 27402624.
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    38. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication. Heart Rhythm. 2017 Jan; 14(1):e3-e40. PMID: 27320515.
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    39. Molina CE, Heijman J, Dobrev D. Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis. Arrhythm Electrophysiol Rev. 2016 May; 5(1):14-9. PMID: 27403288; PMCID: PMC4939305.
    40. Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ. Dysfunction of the ?2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 Jun 1; 310(11):H1583-91. PMID: 27106045.
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    41. Heijman J, Dobrev D. Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiol. 2016 May; 12(3):251-4. PMID: 27091233.
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    42. Hartmann N, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, Fischer TH, Dobrev D, Danner BC, Renner A, Gummert J, Belardinelli L, Frey N, Maier LS, Hasenfuss G, Sossalla S. The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology. J Mol Cell Cardiol. 2016 May; 94:95-106. PMID: 27056421.
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    43. Voigt N, Dobrev D. Atrial-Selective Potassium Channel Blockers. Card Electrophysiol Clin. 2016 Jun; 8(2):411-21. PMID: 27261831.
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    44. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D. Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation. 2016 Mar 15; 133(11):e440-1. PMID: 26976923.
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    45. Nattel S, Dobrev D. Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century. Cardiovasc Res. 2016 Apr 1; 109(4):465-6. PMID: 26857417; PMCID: PMC4777915 [Available on 04/01/17].
    46. Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F. S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB J. 2016 May; 30(5):1849-64. PMID: 26839380; PMCID: PMC4836368 [Available on 05/01/17].
    47. Heijman J, Schirmer I, Dobrev D. The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling. Europace. 2016 Oct; 18(10):1452-1454. PMID: 26826138.
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    48. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 1; 109(3):345-7. PMID: 26782118; PMCID: PMC4752046 [Available on 03/01/17].
    49. Heijman J, Erfanian Abdoust P, Voigt N, Nattel S, Dobrev D. Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. J Physiol. 2016 Feb 1; 594(3):537-53. PMID: 26582329.
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    50. Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 1; 109(4):467-79. PMID: 26705366; PMCID: PMC4777910 [Available on 04/01/17].
    51. Heijman J, Voigt N, Ghezelbash S, Schirmer I, Dobrev D. Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation? J Cardiovasc Pharmacol. 2015 Dec; 66(6):515-22. PMID: 25830486.
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    52. Voigt N, Heijman J, Dobrev D. New antiarrhythmic targets in atrial fibrillation. Future Cardiol. 2015 Nov; 11(6):645-54. PMID: 26609872.
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    53. Weber S, Meyer-Roxlau S, Wagner M, Dobrev D, El-Armouche A. Counteracting Protein Kinase Activity in the Heart: The Multiple Roles of Protein Phosphatases. Front Pharmacol. 2015; 6:270. PMID: 26617522.
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    54. Nattel S, Dobrev D. Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing? J Cardiovasc Pharmacol. 2015 Nov; 66(5):409-11. PMID: 26371951.
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    55. Kirchhof P, Breithardt G, Bax J, Benninger G, Blomstrom-Lundqvist C, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Calvert M, Christoffels V, Crijns H, Dobrev D, Ellinor P, Fabritz L, Fetsch T, Freedman SB, Gerth A, Goette A, Guasch E, Hack G, Haegeli L, Hatem S, Haeusler KG, Heidbüchel H, Heinrich-Nols J, Hidden-Lucet F, Hindricks G, Juul-Möller S, Kääb S, Kappenberger L, Kespohl S, Kotecha D, Lane DA, Leute A, Lewalter T, Meyer R, Mont L, Münzel F, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Piccini JP, Pilmeyer A, Potpara T, Ravens U, Reinecke H, Rostock T, Rustige J, Savelieva I, Schnabel R, Schotten U, Schwichtenberg L, Sinner MF, Steinbeck G, Stoll M, Tavazzi L, Themistoclakis S, Tse HF, Van Gelder IC, Vardas PE, Varpula T, Vincent A, Werring D, Willems S, Ziegler A, Lip GY, Camm AJ. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. Europace. 2016 Jan; 18(1):37-50. PMID: 26481149.
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    56. Schotten U, Hatem S, Ravens U, Jaïs P, Müller FU, Goette A, Rohr S, Antoons G, Pieske B, Scherr D, Oto A, Casadei B, Verheule S, Cartlidge D, Steinmeyer K, Götsche T, Dobrev D, Kockskämper J, Lendeckel U, Fabritz L, Kirchhof P, Camm AJ. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace. 2015 Oct; 17(10):1457-66. PMID: 26364316.
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    57. Voigt N, Pearman CM, Dobrev D, Dibb KM. Methods for isolating atrial cells from large mammals and humans. J Mol Cell Cardiol. 2015 Sep; 86:187-98. PMID: 26186893.
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    58. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324.
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    59. Harada M, Tadevosyan A, Qi X, Xiao J, Liu T, Voigt N, Karck M, Kamler M, Kodama I, Murohara T, Dobrev D, Nattel S. Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression. J Am Coll Cardiol. 2015 Jul 7; 66(1):47-58. PMID: 26139058.
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    60. Zhou XB, Feng YX, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T. Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1852-61. PMID: 26088577.
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    61. Quang KL, Maguy A, Qi XY, Naud P, Xiong F, Tadevosyan A, Shi YF, Chartier D, Tardif JC, Dobrev D, Nattel S. Loss of cardiomyocyte integrin-linked kinase produces an arrhythmogenic cardiomyopathy in mice. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):921-32. PMID: 26071395.
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    62. Heijman J, Heusch G, Dobrev D. Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction. Cardiology. 2015; 132(1):45-8. PMID: 26044937.
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    63. Heijman J, Dobrev D. Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation. Basic Res Cardiol. 2015 Jul; 110(4):41. PMID: 26018792.
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    64. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D. Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation. Circulation. 2015 Jul 14; 132(2):82-92. PMID: 25951834.
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    65. Ghezelbash S, Molina CE, Dobrev D. Altered atrial metabolism: an underappreciated contributor to the initiation and progression of atrial fibrillation. J Am Heart Assoc. 2015 Mar; 4(3):e001808. PMID: 25773300.
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    66. Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 1; 184:190-7. PMID: 25706326.
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    67. Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ. Dysfunction in the ?II spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015 Feb 24; 131(8):695-708. PMID: 25632041; PMCID: PMC4342332.
    68. Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S. Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling. Circ Res. 2015 Feb 27; 116(5):836-45. PMID: 25608527.
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    69. Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73. PMID: 25593058; PMCID: PMC4690213.
    70. Ravens U, Katircioglu-Öztürk D, Wettwer E, Christ T, Dobrev D, Voigt N, Poulet C, Loose S, Simon J, Stein A, Matschke K, Knaut M, Oto E, Oto A, Güvenir HA. Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation. Med Biol Eng Comput. 2015 Mar; 53(3):263-73. PMID: 25466224.
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    71. Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22. PMID: 25389315; PMCID: PMC4270890.
    72. Greiser M, Kerfant BG, Williams GS, Voigt N, Harks E, Dibb KM, Giese A, Meszaros J, Verheule S, Ravens U, Allessie MA, Gammie JS, van der Velden J, Lederer WJ, Dobrev D, Schotten U. Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes. J Clin Invest. 2014 Nov; 124(11):4759-72. PMID: 25329692.
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    73. Chen Y, Wakili R, Xiao J, Wu CT, Luo X, Clauss S, Dawson K, Qi X, Naud P, Shi YF, Tardif JC, Kääb S, Dobrev D, Nattel S. Detailed characterization of microRNA changes in a canine heart failure model: Relationship to arrhythmogenic structural remodeling. J Mol Cell Cardiol. 2014 Dec; 77:113-24. PMID: 25315712.
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    74. Heijman J, Dobrev D. Rat engineered heart tissue: a novel tool in the safety pharmacology toolkit? Basic Res Cardiol. 2014; 109(6):437. PMID: 25209141.
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    157. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54. PMID: 18598963; PMCID: PMC2525570.
    158. Dobrev D. New concepts in understanding and modulating atrial repolarisation in patients with atrial fibrillation. J Interv Card Electrophysiol. 2008 Aug; 22(2):107-10. PMID: 18330686.
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    159. Dobrev D. Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis? Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec; 376(4):227-30. PMID: 17999053.
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    160. Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S. Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008 Jan; 77(1):35-43. PMID: 18006448.
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    161. Eichhorn B, Dobrev D. Vascular large conductance calcium-activated potassium channels: functional role and therapeutic potential. Naunyn Schmiedebergs Arch Pharmacol. 2007 Nov; 376(3):145-55. PMID: 17932654.
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    162. Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U. Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug; 375(6):383-92. PMID: 17593353.
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    163. El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. J Mol Cell Cardiol. 2007 Aug; 43(2):223-9. PMID: 17560599.
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    164. Wettwer E, Christ T, Dobrev D, Ravens U. Novel anti-arrhythmic agents for the treatment of atrial fibrillation. Curr Opin Pharmacol. 2007 Apr; 7(2):214-8. PMID: 17303472.
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    165. Voigt N, Friedrich A, Bock M, Wettwer E, Christ T, Knaut M, Strasser RH, Ravens U, Dobrev D. Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation. Cardiovasc Res. 2007 Jun 1; 74(3):426-37. PMID: 17362895.
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    166. Dobrev D. 5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation? J Mol Cell Cardiol. 2007 Jan; 42(1):51-3. PMID: 17064728.
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    167. El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D. Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation. 2006 Aug 15; 114(7):670-80. PMID: 16894034.
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    168. El-Armouche A, Bednorz A, Pamminger T, Ditz D, Didié M, Dobrev D, Eschenhagen T. Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochem Biophys Res Commun. 2006 Aug 4; 346(3):700-6. PMID: 16774736.
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    169. Dobrev D. Electrical remodeling in atrial fibrillation. Herz. 2006 Apr; 31(2):108-12; quiz 142-3. PMID: 16738832.
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    170. Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005 Jul 26; 112(4):471-81. PMID: 16027256.
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    171. Christ T, Adolph E, Schindelhauer S, Wettwer E, Dobrev D, Wallukat G, Ravens U. Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. Basic Clin Pharmacol Toxicol. 2005 Jun; 96(6):445-52. PMID: 15910408.
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    172. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
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    173. Frey UH, Nückel H, Dobrev D, Manthey I, Sandalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W. Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing. Gene Expr. 2005; 12(2):69-81. PMID: 15892449.
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    174. Christ T, Rauwolf T, Braun M, Dobrev D, Ravens U, Strasser RH. Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo? Pacing Clin Electrophysiol. 2004 Dec; 27(12):1632-7. PMID: 15613126.
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    175. Christ T, Wüst M, Matthes J, Jänchen M, Jürgens S, Herzig S, Wettwer E, Dobrev D, Matschke K, Mebs D, Ravens U. An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec; 370(6):474-83. PMID: 15599709.
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    176. Wettwer E, Hála O, Christ T, Heubach JF, Dobrev D, Knaut M, Varró A, Ravens U. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation. 2004 Oct 19; 110(16):2299-306. PMID: 15477405.
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    177. Dobrev D, Christ T, Ravens U. Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation? Eur Heart J. 2004 Jul; 25(13):1091-2. PMID: 15231365.
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    178. Schindler C, Dobrev D, Grossmann M, Francke K, Pittrow D, Kirch W. Mechanisms of beta-adrenergic receptor-mediated venodilation in humans. Clin Pharmacol Ther. 2004 Jan; 75(1):49-59. PMID: 14749691.
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    179. Balana B, Dobrev D, Wettwer E, Christ T, Knaut M, Ravens U. Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation. J Mol Cell Cardiol. 2003 Dec; 35(12):1399-405. PMID: 14654366.
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    180. Dobrev D. Transcription factors for ion channels: active or passive players in cardiac remodeling? Cardiovasc Res. 2003 Nov 1; 60(2):226-7. PMID: 14613850.
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    181. Dobrev D, Ravens U. Remodeling of cardiomyocyte ion channels in human atrial fibrillation. Basic Res Cardiol. 2003 May; 98(3):137-48. PMID: 12883831.
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    182. Dobrev D, Ravens U. Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum. Eur J Pharmacol. 2003 Feb 14; 461(2-3):105-11. PMID: 12586205.
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    183. Ravens U, Dobrev D. Cardiac sympathetic innervation and control of potassium channel function. J Mol Cell Cardiol. 2003 Feb; 35(2):137-9. PMID: 12606253.
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    184. Christ T, Schier M, Brattström A, Muth G, Hartmann A, Dobrev D, Ravens U. Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test. Europace. 2002 Jul; 4(3):311-5. PMID: 12134978.
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    185. Ravens U, Nitsche I, Haag C, Dobrev D. What is a good tutorial from the student's point of view? Evaluation of tutorials in a newly established PBL block course "Basics of Drug Therapy". Naunyn Schmiedebergs Arch Pharmacol. 2002 Jul; 366(1):69-76. PMID: 12107636.
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    186. Dobrev D, Wettwer E, Kortner A, Knaut M, Schüler S, Ravens U. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res. 2002 May; 54(2):397-404. PMID: 12062344.
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