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DOBROMIR DOBREV

TitleAdjunct Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular Physiology & Biophysics
DivisionMolecular Physiology & Biophysics
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Heijman J, Dobrev D, Crijns HJGM. Targeting supraventricular ectopic complexes: Which approach should be used and how does it affect atrial fibrillation? Int J Cardiol. 2017 Oct 01; 244:202-203. PMID: 28784443.
      View in: PubMed
    2. Fender AC, Dobrev D. Dynamic balance of platelet reactivity in atrial fibrillation PARtially unravelled. Int J Cardiol. 2017 Sep 15; 243:272-273. PMID: 28747029.
      View in: PubMed
    3. Wakili R, Dobrev D. Role of triggers and substrate in heart failure based atrial fibrillation: Is pulmonary vein isolation still the cornerstone of atrial fibrillation therapy? Int J Cardiol. 2017 Sep 15; 243:276-278. PMID: 28747031.
      View in: PubMed
    4. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sossalla S, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Erratum to: Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 Sep; 112(5):51. PMID: 28688054.
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    5. Heijman J, Ghezelbash S, Dobrev D. Investigational antiarrhythmic agents: promising drugs in early clinical development. Expert Opin Investig Drugs. 2017 Jul 10. PMID: 28691539.
      View in: PubMed
    6. Landstrom AP, Dobrev D, Wehrens XHT. Calcium Signaling and Cardiac Arrhythmias. Circ Res. 2017 Jun 09; 120(12):1969-1993. PMID: 28596175.
      View in: PubMed
    7. Meyer-Roxlau S, Lämmle S, Opitz A, Künzel S, Joos JP, Neef S, Sekeres K, Sosalla ST, Schöndube F, Alexiou K, Maier LS, Dobrev D, Guan K, Weber S, El-Armouche A. Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Res Cardiol. 2017 Jul; 112(4):43. PMID: 28597249.
      View in: PubMed
    8. Ji Y, Varkevisser R, Opacic D, Bossu A, Kuiper M, Beekman JDM, Yang S, Khan AP, Dobrev D, Voigt N, Wang MZ, Verheule S, Vos MA, van der Heyden MAG. The inward rectifier current inhibitor PA-6 terminates atrial fibrillation and does not cause ventricular arrhythmias in goat and dog models. Br J Pharmacol. 2017 May 24. PMID: 28542844.
      View in: PubMed
    9. Neef S, Heijman J, Otte K, Dewenter M, Saadatmand AR, Meyer-Roxlau S, Antos CL, Backs J, Dobrev D, Wagner M, Maier LS, El-Armouche A. Chronic loss of inhibitor-1 diminishes cardiac RyR2 phosphorylation despite exaggerated CaMKII activity. Naunyn Schmiedebergs Arch Pharmacol. 2017 Aug; 390(8):857-862. PMID: 28451724.
      View in: PubMed
    10. Dobrev D, Wehrens XH. Calcium-mediated cellular triggered activity in atrial fibrillation. J Physiol. 2017 Feb 09. PMID: 28181690.
      View in: PubMed
    11. Chen Y, Surinkaew S, Naud P, Qi XY, Gillis MA, Shi YF, Tardif JC, Dobrev D, Nattel S. JAK-STAT signaling and the atrial fibrillation promoting fibrotic substrate. Cardiovasc Res. 2017 Feb 02. PMID: 28158495.
      View in: PubMed
    12. Heijman J, Ghezelbash S, Wehrens XH, Dobrev D. Serine/Threonine Phosphatases in Atrial Fibrillation. J Mol Cell Cardiol. 2017 Jan 07. PMID: 28077320.
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    13. Schmidt C, Wiedmann F, Zhou XB, Heijman J, Voigt N, Ratte A, Lang S, Kallenberger SM, Campana C, Weymann A, De Simone R, Szabo G, Ruhparwar A, Kallenbach K, Karck M, Ehrlich JR, Baczkó I, Borggrefe M, Ravens U, Dobrev D, Katus HA, Thomas D. Inverse remodelling of K2P3.1 K+ channel expression and action potential duration in left ventricular dysfunction and atrial fibrillation: implications for patient-specific antiarrhythmic drug therapy. Eur Heart J. 2017 Jan 04. PMID: 28057773.
      View in: PubMed
    14. Abu-Taha IH, Heijman J, Hippe HJ, Wolf NM, El-Armouche A, Nikolaev VO, Schäfer M, Würtz C, Neef S, Voigt N, Baczkó I, Varró A, Müller M, Meder B, Katus HA, Spiger K, Vettel C, Lehmann LH, Backs J, Skolnik EY, Lutz S, Dobrev D, Wieland T. Nucleoside Diphosphate Kinase-C Suppresses cAMP Formation in Human Heart Failure. Circulation. 2016 Dec 07. PMID: 27927712.
      View in: PubMed
    15. Li N, Dobrev D. Hyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation? Int J Cardiol. 2016 Dec 06. PMID: 27993379.
      View in: PubMed
    16. Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, Bers DM, Nerbonne JM. Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics. J Physiol. 2016 Nov 03. PMID: 27808412.
      View in: PubMed
    17. Dobrev D. Unique cardiomyocyte ultrastructure in atria: Role of T tubules in subcellular Ca(2+) signaling and atrial arrhythmogenesis. Heart Rhythm. 2017 Feb; 14(2):282-283. PMID: 27756707.
      View in: PubMed
    18. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS: The Task Force for the management of atrial fibrillation of the European Society of Cardiology (ESC)Developed with the special contribution of the European Heart Rhythm Association (EHRA) of the ESCEndorsed by the European Stroke Organisation (ESO). Eur J Cardiothorac Surg. 2016 Sep 23. PMID: 27663299.
      View in: PubMed
    19. Chiang DY, Heck AJ, Dobrev D, Wehrens XH. Regulating the regulator: Insights into the cardiac protein phosphatase 1 interactome. J Mol Cell Cardiol. 2016 Dec; 101:165-172. PMID: 27663175.
      View in: PubMed
    20. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Europace. 2016 Nov; 18(11):1609-1678. PMID: 27567465.
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    21. Kirchhof P, Benussi S, Kotecha D, Ahlsson A, Atar D, Casadei B, Castella M, Diener HC, Heidbuchel H, Hendriks J, Hindricks G, Manolis AS, Oldgren J, Popescu BA, Schotten U, Van Putte B, Vardas P, Agewall S, Camm J, Baron Esquivias G, Budts W, Carerj S, Casselman F, Coca A, De Caterina R, Deftereos S, Dobrev D, Ferro JM, Filippatos G, Fitzsimons D, Gorenek B, Guenoun M, Hohnloser SH, Kolh P, Lip GY, Manolis A, McMurray J, Ponikowski P, Rosenhek R, Ruschitzka F, Savelieva I, Sharma S, Suwalski P, Tamargo JL, Taylor CJ, Van Gelder IC, Voors AA, Windecker S, Zamorano JL, Zeppenfeld K. 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS. Eur Heart J. 2016 Oct 07; 37(38):2893-2962. PMID: 27567408.
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    22. Nattel S, Dobrev D. Electrophysiological and molecular mechanisms of paroxysmal atrial fibrillation. Nat Rev Cardiol. 2016 Oct; 13(10):575-90. PMID: 27489190.
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    23. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D?Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on Atrial cardiomyopathies: Definition, characterisation, and clinical implication. J Arrhythm. 2016 Aug; 32(4):247-78. PMID: 27588148; PMCID: PMC4996910.
    24. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication. Europace. 2016 Oct; 18(10):1455-1490. PMID: 27402624.
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    25. Goette A, Kalman JM, Aguinaga L, Akar J, Cabrera JA, Chen SA, Chugh SS, Corradi D, D'Avila A, Dobrev D, Fenelon G, Gonzalez M, Hatem SN, Helm R, Hindricks G, Ho SY, Hoit B, Jalife J, Kim YH, Lip GY, Ma CS, Marcus GM, Murray K, Nogami A, Sanders P, Uribe W, Van Wagoner DR, Nattel S. EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: Definition, characterization, and clinical implication. Heart Rhythm. 2017 Jan; 14(1):e3-e40. PMID: 27320515.
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    26. Molina CE, Heijman J, Dobrev D. Differences in Left Versus Right Ventricular Electrophysiological Properties in Cardiac Dysfunction and Arrhythmogenesis. Arrhythm Electrophysiol Rev. 2016 May; 5(1):14-9. PMID: 27403288; PMCID: PMC4939305.
    27. Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ. Dysfunction of the ?2-spectrin-based pathway in human heart failure. Am J Physiol Heart Circ Physiol. 2016 Jun 1; 310(11):H1583-91. PMID: 27106045.
      View in: PubMed
    28. Heijman J, Dobrev D. Challenges to the translation of basic science findings to atrial fibrillation therapies. Future Cardiol. 2016 May; 12(3):251-4. PMID: 27091233.
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    29. Hartmann N, Mason FE, Braun I, Pabel S, Voigt N, Schotola H, Fischer TH, Dobrev D, Danner BC, Renner A, Gummert J, Belardinelli L, Frey N, Maier LS, Hasenfuss G, Sossalla S. The combined effects of ranolazine and dronedarone on human atrial and ventricular electrophysiology. J Mol Cell Cardiol. 2016 May; 94:95-106. PMID: 27056421.
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    30. Voigt N, Dobrev D. Atrial-Selective Potassium Channel Blockers. Card Electrophysiol Clin. 2016 Jun; 8(2):411-21. PMID: 27261831.
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    31. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D. Response to Letter Regarding Article, "Upregulation of K2P3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation". Circulation. 2016 Mar 15; 133(11):e440-1. PMID: 26976923.
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    32. Nattel S, Dobrev D. Deciphering the fundamental mechanisms of atrial fibrillation: a quest for over a century. Cardiovasc Res. 2016 Apr 1; 109(4):465-6. PMID: 26857417; PMCID: PMC4777915 [Available on 04/01/17].
    33. Stathopoulou K, Wittig I, Heidler J, Piasecki A, Richter F, Diering S, van der Velden J, Buck F, Donzelli S, Schröder E, Wijnker PJ, Voigt N, Dobrev D, Sadayappan S, Eschenhagen T, Carrier L, Eaton P, Cuello F. S-glutathiolation impairs phosphoregulation and function of cardiac myosin-binding protein C in human heart failure. FASEB J. 2016 May; 30(5):1849-64. PMID: 26839380; PMCID: PMC4836368 [Available on 05/01/17].
    34. Heijman J, Schirmer I, Dobrev D. The multiple proarrhythmic roles of cardiac calcium-handling abnormalities: triggered activity, conduction abnormalities, beat-to-beat variability, and adverse remodelling. Europace. 2016 Oct; 18(10):1452-1454. PMID: 26826138.
      View in: PubMed
    35. Li N, Dobrev D, Wehrens XH. PITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 1; 109(3):345-7. PMID: 26782118; PMCID: PMC4752046 [Available on 03/01/17].
    36. Heijman J, Erfanian Abdoust P, Voigt N, Nattel S, Dobrev D. Computational models of atrial cellular electrophysiology and calcium handling, and their role in atrial fibrillation. J Physiol. 2016 Feb 1; 594(3):537-53. PMID: 26582329.
      View in: PubMed
    37. Heijman J, Algalarrondo V, Voigt N, Melka J, Wehrens XH, Dobrev D, Nattel S. The value of basic research insights into atrial fibrillation mechanisms as a guide to therapeutic innovation: a critical analysis. Cardiovasc Res. 2016 Apr 1; 109(4):467-79. PMID: 26705366; PMCID: PMC4777910 [Available on 04/01/17].
    38. Heijman J, Voigt N, Ghezelbash S, Schirmer I, Dobrev D. Calcium Handling Abnormalities as a Target for Atrial Fibrillation Therapeutics: How Close to Clinical Implementation? J Cardiovasc Pharmacol. 2015 Dec; 66(6):515-22. PMID: 25830486.
      View in: PubMed
    39. Voigt N, Heijman J, Dobrev D. New antiarrhythmic targets in atrial fibrillation. Future Cardiol. 2015 Nov; 11(6):645-54. PMID: 26609872.
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    40. Nattel S, Dobrev D. Innovative Therapeutics for Atrial Fibrillation: Imminent Breakthroughs or Much Ado About Nothing? J Cardiovasc Pharmacol. 2015 Nov; 66(5):409-11. PMID: 26371951.
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    41. Kirchhof P, Breithardt G, Bax J, Benninger G, Blomstrom-Lundqvist C, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Calvert M, Christoffels V, Crijns H, Dobrev D, Ellinor P, Fabritz L, Fetsch T, Freedman SB, Gerth A, Goette A, Guasch E, Hack G, Haegeli L, Hatem S, Haeusler KG, Heidbüchel H, Heinrich-Nols J, Hidden-Lucet F, Hindricks G, Juul-Möller S, Kääb S, Kappenberger L, Kespohl S, Kotecha D, Lane DA, Leute A, Lewalter T, Meyer R, Mont L, Münzel F, Nabauer M, Nielsen JC, Oeff M, Oldgren J, Oto A, Piccini JP, Pilmeyer A, Potpara T, Ravens U, Reinecke H, Rostock T, Rustige J, Savelieva I, Schnabel R, Schotten U, Schwichtenberg L, Sinner MF, Steinbeck G, Stoll M, Tavazzi L, Themistoclakis S, Tse HF, Van Gelder IC, Vardas PE, Varpula T, Vincent A, Werring D, Willems S, Ziegler A, Lip GY, Camm AJ. A roadmap to improve the quality of atrial fibrillation management: proceedings from the fifth Atrial Fibrillation Network/European Heart Rhythm Association consensus conference. Europace. 2016 Jan; 18(1):37-50. PMID: 26481149.
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    42. Schotten U, Hatem S, Ravens U, Jaïs P, Müller FU, Goette A, Rohr S, Antoons G, Pieske B, Scherr D, Oto A, Casadei B, Verheule S, Cartlidge D, Steinmeyer K, Götsche T, Dobrev D, Kockskämper J, Lendeckel U, Fabritz L, Kirchhof P, Camm AJ. The European Network for Translational Research in Atrial Fibrillation (EUTRAF): objectives and initial results. Europace. 2015 Oct; 17(10):1457-66. PMID: 26364316.
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    43. Voigt N, Pearman CM, Dobrev D, Dibb KM. Methods for isolating atrial cells from large mammals and humans. J Mol Cell Cardiol. 2015 Sep; 86:187-98. PMID: 26186893.
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    44. Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XH. Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505. PMID: 26162324.
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    45. Harada M, Tadevosyan A, Qi X, Xiao J, Liu T, Voigt N, Karck M, Kamler M, Kodama I, Murohara T, Dobrev D, Nattel S. Atrial Fibrillation Activates AMP-Dependent Protein Kinase and its Regulation of Cellular Calcium Handling: Potential Role in Metabolic Adaptation and Prevention of Progression. J Am Coll Cardiol. 2015 Jul 7; 66(1):47-58. PMID: 26139058.
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    46. Zhou XB, Feng YX, Sun Q, Lukowski R, Qiu Y, Spiger K, Li Z, Ruth P, Korth M, Skolnik EY, Borggrefe M, Dobrev D, Wieland T. Nucleoside diphosphate kinase B-activated intermediate conductance potassium channels are critical for neointima formation in mouse carotid arteries. Arterioscler Thromb Vasc Biol. 2015 Aug; 35(8):1852-61. PMID: 26088577.
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    47. Quang KL, Maguy A, Qi XY, Naud P, Xiong F, Tadevosyan A, Shi YF, Chartier D, Tardif JC, Dobrev D, Nattel S. Loss of cardiomyocyte integrin-linked kinase produces an arrhythmogenic cardiomyopathy in mice. Circ Arrhythm Electrophysiol. 2015 Aug; 8(4):921-32. PMID: 26071395.
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    48. Heijman J, Heusch G, Dobrev D. Tools to Keep the Clock Ticking: Molecular Approaches to Treat Sinus Node Dysfunction. Cardiology. 2015; 132(1):45-8. PMID: 26044937.
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    49. Heijman J, Dobrev D. Irregular rhythm and atrial metabolism are key for the evolution of proarrhythmic atrial remodeling in atrial fibrillation. Basic Res Cardiol. 2015 Jul; 110(4):41. PMID: 26018792.
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    50. Schmidt C, Wiedmann F, Voigt N, Zhou XB, Heijman J, Lang S, Albert V, Kallenberger S, Ruhparwar A, Szabó G, Kallenbach K, Karck M, Borggrefe M, Biliczki P, Ehrlich JR, Baczkó I, Lugenbiel P, Schweizer PA, Donner BC, Katus HA, Dobrev D, Thomas D. Upregulation of K(2P)3.1 K+ Current Causes Action Potential Shortening in Patients With Chronic Atrial Fibrillation. Circulation. 2015 Jul 14; 132(2):82-92. PMID: 25951834.
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    51. Ghezelbash S, Molina CE, Dobrev D. Altered atrial metabolism: an underappreciated contributor to the initiation and progression of atrial fibrillation. J Am Heart Assoc. 2015 Mar; 4(3):e001808. PMID: 25773300.
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    52. Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 1; 184:190-7. PMID: 25706326.
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    53. Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ. Dysfunction in the ?II spectrin-dependent cytoskeleton underlies human arrhythmia. Circulation. 2015 Feb 24; 131(8):695-708. PMID: 25632041; PMCID: PMC4342332.
    54. Qi XY, Huang H, Ordog B, Luo X, Naud P, Sun Y, Wu CT, Dawson K, Tadevosyan A, Chen Y, Harada M, Dobrev D, Nattel S. Fibroblast inward-rectifier potassium current upregulation in profibrillatory atrial remodeling. Circ Res. 2015 Feb 27; 116(5):836-45. PMID: 25608527.
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    55. Chiang DY, Lebesgue N, Beavers DL, Alsina KM, Damen JM, Voigt N, Dobrev D, Wehrens XH, Scholten A. Alterations in the interactome of serine/threonine protein phosphatase type-1 in atrial fibrillation patients. J Am Coll Cardiol. 2015 Jan 20; 65(2):163-73. PMID: 25593058; PMCID: PMC4690213.
    56. Ravens U, Katircioglu-Öztürk D, Wettwer E, Christ T, Dobrev D, Voigt N, Poulet C, Loose S, Simon J, Stein A, Matschke K, Knaut M, Oto E, Oto A, Güvenir HA. Application of the RIMARC algorithm to a large data set of action potentials and clinical parameters for risk prediction of atrial fibrillation. Med Biol Eng Comput. 2015 Mar; 53(3):263-73. PMID: 25466224.
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    57. Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li N. Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22. PMID: 25389315; PMCID: PMC4270890.
    58. Greiser M, Kerfant BG, Williams GS, Voigt N, Harks E, Dibb KM, Giese A, Meszaros J, Verheule S, Ravens U, Allessie MA, Gammie JS, van der Velden J, Lederer WJ, Dobrev D, Schotten U. Tachycardia-induced silencing of subcellular Ca2+ signaling in atrial myocytes. J Clin Invest. 2014 Nov; 124(11):4759-72. PMID: 25329692.
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    59. Chen Y, Wakili R, Xiao J, Wu CT, Luo X, Clauss S, Dawson K, Qi X, Naud P, Shi YF, Tardif JC, Kääb S, Dobrev D, Nattel S. Detailed characterization of microRNA changes in a canine heart failure model: Relationship to arrhythmogenic structural remodeling. J Mol Cell Cardiol. 2014 Dec; 77:113-24. PMID: 25315712.
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    60. Heijman J, Dobrev D. Rat engineered heart tissue: a novel tool in the safety pharmacology toolkit? Basic Res Cardiol. 2014; 109(6):437. PMID: 25209141.
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    61. Kreusser MM, Lehmann LH, Keranov S, Hoting MO, Oehl U, Kohlhaas M, Reil JC, Neumann K, Schneider MD, Hill JA, Dobrev D, Maack C, Maier LS, Gröne HJ, Katus HA, Olson EN, Backs J. Cardiac CaM Kinase II genes ? and ? contribute to adverse remodeling but redundantly inhibit calcineurin-induced myocardial hypertrophy. Circulation. 2014 Oct 7; 130(15):1262-73. PMID: 25124496; PMCID: PMC4316667.
    62. Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XH. Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 1; 103(1):178-87. PMID: 24812280; PMCID: PMC4133595.
    63. Andrade J, Khairy P, Dobrev D, Nattel S. The clinical profile and pathophysiology of atrial fibrillation: relationships among clinical features, epidemiology, and mechanisms. Circ Res. 2014 Apr 25; 114(9):1453-68. PMID: 24763464.
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    64. Heijman J, Voigt N, Nattel S, Dobrev D. Cellular and molecular electrophysiology of atrial fibrillation initiation, maintenance, and progression. Circ Res. 2014 Apr 25; 114(9):1483-99. PMID: 24763466.
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    65. Dobrev D, Wehrens XH. Role of RyR2 phosphorylation in heart failure and arrhythmias: Controversies around ryanodine receptor phosphorylation in cardiac disease. Circ Res. 2014 Apr 11; 114(8):1311-9; discussion 1319. PMID: 24723656; PMCID: PMC4008932.
    66. Heijman J, Voigt N, Wehrens XH, Dobrev D. Calcium dysregulation in atrial fibrillation: the role of CaMKII. Front Pharmacol. 2014; 5:30. PMID: 24624086; PMCID: PMC3940963.
    67. Harada M, Luo X, Murohara T, Yang B, Dobrev D, Nattel S. MicroRNA regulation and cardiac calcium signaling: role in cardiac disease and therapeutic potential. Circ Res. 2014 Feb 14; 114(4):689-705. PMID: 24526675.
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    68. Voigt N, Abu-Taha I, Heijman J, Dobrev D. Constitutive activity of the acetylcholine-activated potassium current IK,ACh in cardiomyocytes. Adv Pharmacol. 2014; 70:393-409. PMID: 24931203.
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    69. Heijman J, Voigt N, Carlsson LG, Dobrev D. Cardiac safety assays. Curr Opin Pharmacol. 2014 Apr; 15:16-21. PMID: 24721649.
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    70. Qi XY, Diness JG, Brundel BJ, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D, Grunnet M, Nattel S. Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog. Circulation. 2014 Jan 28; 129(4):430-40. PMID: 24190961.
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    71. Heijman J, Dewenter M, El-Armouche A, Dobrev D. Function and regulation of serine/threonine phosphatases in the healthy and diseased heart. J Mol Cell Cardiol. 2013 Nov; 64:90-8. PMID: 24051368.
      View in: PubMed
    72. Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson ME. Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57. PMID: 24030498; PMCID: PMC3876034.
    73. Kirchhof P, Breithardt G, Aliot E, Al Khatib S, Apostolakis S, Auricchio A, Bailleul C, Bax J, Benninger G, Blomstrom-Lundqvist C, Boersma L, Boriani G, Brandes A, Brown H, Brueckmann M, Calkins H, Casadei B, Clemens A, Crijns H, Derwand R, Dobrev D, Ezekowitz M, Fetsch T, Gerth A, Gillis A, Gulizia M, Hack G, Haegeli L, Hatem S, Georg Häusler K, Heidbüchel H, Hernandez-Brichis J, Jais P, Kappenberger L, Kautzner J, Kim S, Kuck KH, Lane D, Leute A, Lewalter T, Meyer R, Mont L, Moses G, Mueller M, Münzel F, Näbauer M, Nielsen JC, Oeff M, Oto A, Pieske B, Pisters R, Potpara T, Rasmussen L, Ravens U, Reiffel J, Richard-Lordereau I, Schäfer H, Schotten U, Stegink W, Stein K, Steinbeck G, Szumowski L, Tavazzi L, Themistoclakis S, Thomitzek K, Van Gelder IC, von Stritzky B, Vincent A, Werring D, Willems S, Lip GY, Camm AJ. Personalized management of atrial fibrillation: Proceedings from the fourth Atrial Fibrillation competence NETwork/European Heart Rhythm Association consensus conference. Europace. 2013 Nov; 15(11):1540-56. PMID: 23981824.
      View in: PubMed
    74. Heijman J, Heusch G, Dobrev D. Pleiotropic effects of antiarrhythmic agents: dronedarone in the treatment of atrial fibrillation. Clin Med Insights Cardiol. 2013; 7:127-40. PMID: 23997577.
      View in: PubMed
    75. Heijman J, Voigt N, Abu-Taha IH, Dobrev D. Rhythm control of atrial fibrillation in heart failure. Heart Fail Clin. 2013 Oct; 9(4):407-15, vii-viii. PMID: 24054474.
      View in: PubMed
    76. Levay M, Krobert KA, Wittig K, Voigt N, Bermudez M, Wolber G, Dobrev D, Levy FO, Wieland T. NSC23766, a widely used inhibitor of Rac1 activation, additionally acts as a competitive antagonist at muscarinic acetylcholine receptors. J Pharmacol Exp Ther. 2013 Oct; 347(1):69-79. PMID: 23887096.
      View in: PubMed
    77. Le Quang K, Benito B, Naud P, Qi XY, Shi YF, Tardif JC, Gillis MA, Dobrev D, Charpentier F, Nattel S. T-type calcium current contributes to escape automaticity and governs the occurrence of lethal arrhythmias after atrioventricular block in mice. Circ Arrhythm Electrophysiol. 2013 Aug; 6(4):799-808. PMID: 23884198.
      View in: PubMed
    78. Voigt N, Zhou XB, Dobrev D. Isolation of human atrial myocytes for simultaneous measurements of Ca2+ transients and membrane currents. J Vis Exp. 2013; (77):e50235. PMID: 23852392.
      View in: PubMed
    79. Mehel H, Emons J, Vettel C, Wittköpper K, Seppelt D, Dewenter M, Lutz S, Sossalla S, Maier LS, Lechêne P, Leroy J, Lefebvre F, Varin A, Eschenhagen T, Nattel S, Dobrev D, Zimmermann WH, Nikolaev VO, Vandecasteele G, Fischmeister R, El-Armouche A. Phosphodiesterase-2 is up-regulated in human failing hearts and blunts ?-adrenergic responses in cardiomyocytes. J Am Coll Cardiol. 2013 Oct 22; 62(17):1596-606. PMID: 23810893.
      View in: PubMed
    80. Tsuji Y, Dobrev D. Safety and efficacy of vernakalant for acute cardioversion of atrial fibrillation: an update. Vasc Health Risk Manag. 2013; 9:165-75. PMID: 23637539.
      View in: PubMed
    81. Heijman J, Dobrev D. KCNQ1 autoantibodies: another way to regulate IKs. Cardiovasc Res. 2013 Jun 1; 98(3):329-31. PMID: 23615563.
      View in: PubMed
    82. Guasch E, Benito B, Qi X, Cifelli C, Naud P, Shi Y, Mighiu A, Tardif JC, Tadevosyan A, Chen Y, Gillis MA, Iwasaki YK, Dobrev D, Mont L, Heximer S, Nattel S. Atrial fibrillation promotion by endurance exercise: demonstration and mechanistic exploration in an animal model. J Am Coll Cardiol. 2013 Jul 2; 62(1):68-77. PMID: 23583240.
      View in: PubMed
    83. Voigt N, Heijman J, Trausch A, Mintert-Jancke E, Pott L, Ravens U, Dobrev D. Impaired Na?-dependent regulation of acetylcholine-activated inward-rectifier K? current modulates action potential rate dependence in patients with chronic atrial fibrillation. J Mol Cell Cardiol. 2013 Aug; 61:142-52. PMID: 23531443.
      View in: PubMed
    84. Dawson K, Wakili R, Ordög B, Clauss S, Chen Y, Iwasaki Y, Voigt N, Qi XY, Sinner MF, Dobrev D, Kääb S, Nattel S. MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation. Circulation. 2013 Apr 9; 127(14):1466-75, 1475e1-28. PMID: 23459615.
      View in: PubMed
    85. Tsuji Y, Heijman J, Nattel S, Dobrev D. Electrical storm: recent pathophysiological insights and therapeutic consequences. Basic Res Cardiol. 2013 Mar; 108(2):336. PMID: 23429935.
      View in: PubMed
    86. Heijman J, Voigt N, Dobrev D. New directions in antiarrhythmic drug therapy for atrial fibrillation. Future Cardiol. 2013 Jan; 9(1):71-88. PMID: 23259476.
      View in: PubMed
    87. Voigt N, Dobrev D. The biology of human pulmonary veins: does it help us to better understand AF pathophysiology in patients? Heart Rhythm. 2013 Mar; 10(3):392-3. PMID: 23237913.
      View in: PubMed
    88. Voigt N, Dobrev D. Cellular and molecular correlates of ectopic activity in patients with atrial fibrillation. Europace. 2012 Nov; 14 Suppl 5:v97-v105. PMID: 23104921.
      View in: PubMed
    89. Zhou X, Dobrev D. Voltage-gated Na? channels: novel players in fibroblast-to-myofibroblast transition with a potential role in atrial arrhythmogenesis? J Physiol. 2012 Oct 15; 590(20):4975. PMID: 23082023.
      View in: PubMed
    90. Harada M, Luo X, Qi XY, Tadevosyan A, Maguy A, Ordog B, Ledoux J, Kato T, Naud P, Voigt N, Shi Y, Kamiya K, Murohara T, Kodama I, Tardif JC, Schotten U, Van Wagoner DR, Dobrev D, Nattel S. Transient receptor potential canonical-3 channel-dependent fibroblast regulation in atrial fibrillation. Circulation. 2012 Oct 23; 126(17):2051-64. PMID: 22992321.
      View in: PubMed
    91. Zhou X, Wulfsen I, Korth M, McClafferty H, Lukowski R, Shipston MJ, Ruth P, Dobrev D, Wieland T. Palmitoylation and membrane association of the stress axis regulated insert (STREX) controls BK channel regulation by protein kinase C. J Biol Chem. 2012 Sep 14; 287(38):32161-71. PMID: 22843729.
      View in: PubMed
    92. Dobrev D. Is altered atrial microRNA-ome a critical contributor to the pathophysiology of atrial fibrillation? Basic Res Cardiol. 2012 Sep; 107(5):284. PMID: 22802051.
      View in: PubMed
    93. Heijman J, Voigt N, Nattel S, Dobrev D. Calcium handling and atrial fibrillation. Wien Med Wochenschr. 2012 Jul; 162(13-14):287-91. PMID: 22695810.
      View in: PubMed
    94. Heijman J, Dobrev D. Systems approaches to post-operative atrial fibrillation - do they help us to better understand the ionic basis of the arrhythmogenic substrate? J Mol Cell Cardiol. 2012 Sep; 53(3):320-2. PMID: 22742961.
      View in: PubMed
    95. Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Skårdal K, Wisløff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XH. Role of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83. PMID: 22511749; PMCID: PMC3371642.
    96. Nattel S, Dobrev D. The multidimensional role of calcium in atrial fibrillation pathophysiology: mechanistic insights and therapeutic opportunities. Eur Heart J. 2012 Aug; 33(15):1870-7. PMID: 22507975.
      View in: PubMed
    97. Dobrev D, Carlsson L, Nattel S. Novel molecular targets for atrial fibrillation therapy. Nat Rev Drug Discov. 2012 Apr; 11(4):275-91. PMID: 22460122.
      View in: PubMed
    98. Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev D. Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 1; 125(17):2059-70. PMID: 22456474; PMCID: PMC4663993.
    99. Voigt N, Nattel S, Dobrev D. Proarrhythmic atrial calcium cycling in the diseased heart. Adv Exp Med Biol. 2012; 740:1175-91. PMID: 22453988.
      View in: PubMed
    100. Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XH. Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 3; 110(3):465-70. PMID: 22158709; PMCID: PMC3272138.
    101. Grandi E, Pandit SV, Voigt N, Workman AJ, Dobrev D, Jalife J, Bers DM. Human atrial action potential and Ca2+ model: sinus rhythm and chronic atrial fibrillation. Circ Res. 2011 Oct 14; 109(9):1055-66. PMID: 21921263.
      View in: PubMed
    102. Makary S, Voigt N, Maguy A, Wakili R, Nishida K, Harada M, Dobrev D, Nattel S. Differential protein kinase C isoform regulation and increased constitutive activity of acetylcholine-regulated potassium channels in atrial remodeling. Circ Res. 2011 Oct 14; 109(9):1031-43. PMID: 21903936.
      View in: PubMed
    103. Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJ. Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22. PMID: 21859974; PMCID: PMC3211046.
    104. Wakili R, Voigt N, Kääb S, Dobrev D, Nattel S. Recent advances in the molecular pathophysiology of atrial fibrillation. J Clin Invest. 2011 Aug; 121(8):2955-68. PMID: 21804195.
      View in: PubMed
    105. Kirchhof P, Lip GY, Van Gelder IC, Bax J, Hylek E, Kaab S, Schotten U, Wegscheider K, Boriani G, Brandes A, Ezekowitz M, Diener H, Haegeli L, Heidbuchel H, Lane D, Mont L, Willems S, Dorian P, Aunes-Jansson M, Blomstrom-Lundqvist C, Borentain M, Breitenstein S, Brueckmann M, Cater N, Clemens A, Dobrev D, Dubner S, Edvardsson NG, Friberg L, Goette A, Gulizia M, Hatala R, Horwood J, Szumowski L, Kappenberger L, Kautzner J, Leute A, Lobban T, Meyer R, Millerhagen J, Morgan J, Muenzel F, Nabauer M, Baertels C, Oeff M, Paar D, Polifka J, Ravens U, Rosin L, Stegink W, Steinbeck G, Vardas P, Vincent A, Walter M, Breithardt G, Camm AJ. Comprehensive risk reduction in patients with atrial fibrillation: emerging diagnostic and therapeutic options--a report from the 3rd Atrial Fibrillation Competence NETwork/European Heart Rhythm Association consensus conference. Europace. 2012 Jan; 14(1):8-27. PMID: 21791573.
      View in: PubMed
    106. Swaminathan PD, Purohit A, Soni S, Voigt N, Singh MV, Glukhov AV, Gao Z, He BJ, Luczak ED, Joiner ML, Kutschke W, Yang J, Donahue JK, Weiss RM, Grumbach IM, Ogawa M, Chen PS, Efimov I, Dobrev D, Mohler PJ, Hund TJ, Anderson ME. Oxidized CaMKII causes cardiac sinus node dysfunction in mice. J Clin Invest. 2011 Aug; 121(8):3277-88. PMID: 21785215.
      View in: PubMed
    107. Le Quang K, Naud P, Qi XY, Duval F, Shi YF, Gillis MA, Comtois P, Tardif JC, Li D, Levesque PC, Dobrev D, Charpentier F, Nattel S. Role of T-type calcium channel subunits in post-myocardial infarction remodelling probed with genetically engineered mice. Cardiovasc Res. 2011 Aug 1; 91(3):420-8. PMID: 21622683.
      View in: PubMed
    108. Bugert P, Elmas E, Stach K, Weiss C, Kälsch T, Dobrev D, Borggrefe M. No evidence for an association between the rs2824292 variant at chromosome 21q21 and ventricular fibrillation during acute myocardial infarction in a German population. Clin Chem Lab Med. 2011 Jul; 49(7):1237-9. PMID: 21574885.
      View in: PubMed
    109. Tsuji Y, Hojo M, Voigt N, El-Armouche A, Inden Y, Murohara T, Dobrev D, Nattel S, Kodama I, Kamiya K. Ca(2+)-related signaling and protein phosphorylation abnormalities play central roles in a new experimental model of electrical storm. Circulation. 2011 May 24; 123(20):2192-203. PMID: 21555709.
      View in: PubMed
    110. Wittköpper K, Dobrev D, Eschenhagen T, El-Armouche A. Phosphatase-1 inhibitor-1 in physiological and pathological ?-adrenoceptor signalling. Cardiovasc Res. 2011 Aug 1; 91(3):392-401. PMID: 21354993.
      View in: PubMed
    111. Dobrev D, Nattel S. New insights into the molecular basis of atrial fibrillation: mechanistic and therapeutic implications. Cardiovasc Res. 2011 Mar 1; 89(4):689-91. PMID: 21296897.
      View in: PubMed
    112. Nishida K, Qi XY, Wakili R, Comtois P, Chartier D, Harada M, Iwasaki YK, Romeo P, Maguy A, Dobrev D, Michael G, Talajic M, Nattel S. Mechanisms of atrial tachyarrhythmias associated with coronary artery occlusion in a chronic canine model. Circulation. 2011 Jan 18; 123(2):137-46. PMID: 21200008.
      View in: PubMed
    113. Boontje NM, Merkus D, Zaremba R, Versteilen A, de Waard MC, Mearini G, de Beer VJ, Carrier L, Walker LA, Niessen HW, Dobrev D, Stienen GJ, Duncker DJ, van der Velden J. Enhanced myofilament responsiveness upon ?-adrenergic stimulation in post-infarct remodeled myocardium. J Mol Cell Cardiol. 2011 Mar; 50(3):487-99. PMID: 21156182.
      View in: PubMed
    114. Dobrev D, Voigt N, Wehrens XH. The ryanodine receptor channel as a molecular motif in atrial fibrillation: pathophysiological and therapeutic implications. Cardiovasc Res. 2011 Mar 1; 89(4):734-43. PMID: 20943673; PMCID: PMC3039246.
    115. Goette A, Hammwöhner M, Bukowska A, Scalera F, Martens-Lobenhoffer J, Dobrev D, Ravens U, Weinert S, Medunjanin S, Lendeckel U, Bode-Böger SM. The impact of rapid atrial pacing on ADMA and endothelial NOS. Int J Cardiol. 2012 Jan 26; 154(2):141-6. PMID: 20926145.
      View in: PubMed
    116. Wakili R, Yeh YH, Yan Qi X, Greiser M, Chartier D, Nishida K, Maguy A, Villeneuve LR, Boknik P, Voigt N, Krysiak J, Kääb S, Ravens U, Linke WA, Stienen GJ, Shi Y, Tardif JC, Schotten U, Dobrev D, Nattel S. Multiple potential molecular contributors to atrial hypocontractility caused by atrial tachycardia remodeling in dogs. Circ Arrhythm Electrophysiol. 2010 Oct; 3(5):530-41. PMID: 20660541.
      View in: PubMed
    117. Voigt N, Trausch A, Knaut M, Matschke K, Varró A, Van Wagoner DR, Nattel S, Ravens U, Dobrev D. Left-to-right atrial inward rectifier potassium current gradients in patients with paroxysmal versus chronic atrial fibrillation. Circ Arrhythm Electrophysiol. 2010 Oct; 3(5):472-80. PMID: 20657029.
      View in: PubMed
    118. Lendeckel U, Dobrev D, Goette A. Aldosterone-receptor antagonism as a potential therapeutic option for atrial fibrillation. Br J Pharmacol. 2010 Apr; 159(8):1581-3. PMID: 20388187.
      View in: PubMed
    119. Wittköpper K, Fabritz L, Neef S, Ort KR, Grefe C, Unsöld B, Kirchhof P, Maier LS, Hasenfuss G, Dobrev D, Eschenhagen T, El-Armouche A. Constitutively active phosphatase inhibitor-1 improves cardiac contractility in young mice but is deleterious after catecholaminergic stress and with aging. J Clin Invest. 2010 Feb; 120(2):617-26. PMID: 20071777.
      View in: PubMed
    120. Dobrev D, Wehrens XH. Calmodulin kinase II, sarcoplasmic reticulum Ca2+ leak, and atrial fibrillation. Trends Cardiovasc Med. 2010 Jan; 20(1):30-4. PMID: 20685575; PMCID: PMC2917388.
    121. Voigt N, Makary S, Nattel S, Dobrev D. Voltage-clamp-based methods for the detection of constitutively active acetylcholine-gated I(K,ACh) channels in the diseased heart. Methods Enzymol. 2010; 484:653-75. PMID: 21036255.
      View in: PubMed
    122. Nishida K, Michael G, Dobrev D, Nattel S. Animal models for atrial fibrillation: clinical insights and scientific opportunities. Europace. 2010 Feb; 12(2):160-72. PMID: 19875395.
      View in: PubMed
    123. Dobrev D. Atrial Ca2+ signaling in atrial fibrillation as an antiarrhythmic drug target. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar; 381(3):195-206. PMID: 19784635.
      View in: PubMed
    124. Voigt N, Rozmaritsa N, Trausch A, Zimniak T, Christ T, Wettwer E, Matschke K, Dobrev D, Ravens U. Inhibition of IK,ACh current may contribute to clinical efficacy of class I and class III antiarrhythmic drugs in patients with atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2010 Mar; 381(3):251-9. PMID: 19760273.
      View in: PubMed
    125. Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, Müller FU, Schmitz W, Schotten U, Anderson ME, Valderrábano M, Dobrev D, Wehrens XH. Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51. PMID: 19603549; PMCID: PMC2701862.
    126. Dobrev D. Ion channel portrait of the human sinus node: useful for a better understanding of sinus node function and dysfunction in humans? Circulation. 2009 Mar 31; 119(12):1556-8. PMID: 19332478.
      View in: PubMed
    127. Goette A, Bukowska A, Dobrev D, Pfeiffenberger J, Morawietz H, Strugala D, Wiswedel I, Röhl FW, Wolke C, Bergmann S, Bramlage P, Ravens U, Lendeckel U. Acute atrial tachyarrhythmia induces angiotensin II type 1 receptor-mediated oxidative stress and microvascular flow abnormalities in the ventricles. Eur Heart J. 2009 Jun; 30(11):1411-20. PMID: 19269986.
      View in: PubMed
    128. Greiser M, Neuberger HR, Harks E, El-Armouche A, Boknik P, de Haan S, Verheyen F, Verheule S, Schmitz W, Ravens U, Nattel S, Allessie MA, Dobrev D, Schotten U. Distinct contractile and molecular differences between two goat models of atrial dysfunction: AV block-induced atrial dilatation and atrial fibrillation. J Mol Cell Cardiol. 2009 Mar; 46(3):385-94. PMID: 19100271.
      View in: PubMed
    129. Dobrev D, Nattel S. Calcium handling abnormalities in atrial fibrillation as a target for innovative therapeutics. J Cardiovasc Pharmacol. 2008 Oct; 52(4):293-9. PMID: 18791467.
      View in: PubMed
    130. Michael G, Xiao L, Qi XY, Dobrev D, Nattel S. Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis. Cardiovasc Res. 2009 Feb 15; 81(3):491-9. PMID: 18826964.
      View in: PubMed
    131. Qi XY, Yeh YH, Xiao L, Burstein B, Maguy A, Chartier D, Villeneuve LR, Brundel BJ, Dobrev D, Nattel S. Cellular signaling underlying atrial tachycardia remodeling of L-type calcium current. Circ Res. 2008 Oct 10; 103(8):845-54. PMID: 18723446.
      View in: PubMed
    132. El-Armouche A, Wittköpper K, Degenhardt F, Weinberger F, Didié M, Melnychenko I, Grimm M, Peeck M, Zimmermann WH, Unsöld B, Hasenfuss G, Dobrev D, Eschenhagen T. Phosphatase inhibitor-1-deficient mice are protected from catecholamine-induced arrhythmias and myocardial hypertrophy. Cardiovasc Res. 2008 Dec 1; 80(3):396-406. PMID: 18689792.
      View in: PubMed
    133. Yeh YH, Wakili R, Qi XY, Chartier D, Boknik P, Kääb S, Ravens U, Coutu P, Dobrev D, Nattel S. Calcium-handling abnormalities underlying atrial arrhythmogenesis and contractile dysfunction in dogs with congestive heart failure. Circ Arrhythm Electrophysiol. 2008 Jun 1; 1(2):93-102. PMID: 19808399.
      View in: PubMed
    134. Dobrev D, Wettwer E. Four and a half LIM protein 1: a novel chaperone for atrium-specific Kv1.5 channels with a potential role in atrial arrhythmogenesis. Cardiovasc Res. 2008 Jun 1; 78(3):411-2. PMID: 18390898.
      View in: PubMed
    135. Nattel S, Burstein B, Dobrev D. Atrial remodeling and atrial fibrillation: mechanisms and implications. Circ Arrhythm Electrophysiol. 2008 Apr; 1(1):62-73. PMID: 19808395.
      View in: PubMed
    136. Sood S, Chelu MG, van Oort RJ, Skapura D, Santonastasi M, Dobrev D, Wehrens XH. Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation. Heart Rhythm. 2008 Jul; 5(7):1047-54. PMID: 18598963; PMCID: PMC2525570.
    137. Dobrev D. Cardiomyocyte Ca2+ overload in atrial tachycardia: is blockade of L-type Ca2+ channels a promising approach to prevent electrical remodeling and arrhythmogenesis? Naunyn Schmiedebergs Arch Pharmacol. 2007 Dec; 376(4):227-30. PMID: 17999053.
      View in: PubMed
    138. Voigt N, Maguy A, Yeh YH, Qi X, Ravens U, Dobrev D, Nattel S. Changes in I K, ACh single-channel activity with atrial tachycardia remodelling in canine atrial cardiomyocytes. Cardiovasc Res. 2008 Jan; 77(1):35-43. PMID: 18006448.
      View in: PubMed
    139. Greiser M, Halaszovich CR, Frechen D, Boknik P, Ravens U, Dobrev D, Lückhoff A, Schotten U. Pharmacological evidence for altered src kinase regulation of I (Ca,L) in patients with chronic atrial fibrillation. Naunyn Schmiedebergs Arch Pharmacol. 2007 Aug; 375(6):383-92. PMID: 17593353.
      View in: PubMed
    140. El-Armouche A, Pohlmann L, Schlossarek S, Starbatty J, Yeh YH, Nattel S, Dobrev D, Eschenhagen T, Carrier L. Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure. J Mol Cell Cardiol. 2007 Aug; 43(2):223-9. PMID: 17560599.
      View in: PubMed
    141. Wettwer E, Christ T, Dobrev D, Ravens U. Novel anti-arrhythmic agents for the treatment of atrial fibrillation. Curr Opin Pharmacol. 2007 Apr; 7(2):214-8. PMID: 17303472.
      View in: PubMed
    142. Voigt N, Friedrich A, Bock M, Wettwer E, Christ T, Knaut M, Strasser RH, Ravens U, Dobrev D. Differential phosphorylation-dependent regulation of constitutively active and muscarinic receptor-activated IK,ACh channels in patients with chronic atrial fibrillation. Cardiovasc Res. 2007 Jun 1; 74(3):426-37. PMID: 17362895.
      View in: PubMed
    143. Dobrev D. 5-hydroxytryptamine and atrial arrhythmogenesis: a "culprit mechanism" or bystander in patients with chronic atrial fibrillation? J Mol Cell Cardiol. 2007 Jan; 42(1):51-3. PMID: 17064728.
      View in: PubMed
    144. El-Armouche A, Boknik P, Eschenhagen T, Carrier L, Knaut M, Ravens U, Dobrev D. Molecular determinants of altered Ca2+ handling in human chronic atrial fibrillation. Circulation. 2006 Aug 15; 114(7):670-80. PMID: 16894034.
      View in: PubMed
    145. El-Armouche A, Bednorz A, Pamminger T, Ditz D, Didié M, Dobrev D, Eschenhagen T. Role of calcineurin and protein phosphatase-2A in the regulation of phosphatase inhibitor-1 in cardiac myocytes. Biochem Biophys Res Commun. 2006 Aug 4; 346(3):700-6. PMID: 16774736.
      View in: PubMed
    146. Dobrev D. Electrical remodeling in atrial fibrillation. Herz. 2006 Apr; 31(2):108-12; quiz 142-3. PMID: 16738832.
      View in: PubMed
    147. Gaborit N, Steenman M, Lamirault G, Le Meur N, Le Bouter S, Lande G, Léger J, Charpentier F, Christ T, Dobrev D, Escande D, Nattel S, Demolombe S. Human atrial ion channel and transporter subunit gene-expression remodeling associated with valvular heart disease and atrial fibrillation. Circulation. 2005 Jul 26; 112(4):471-81. PMID: 16027256.
      View in: PubMed
    148. Christ T, Adolph E, Schindelhauer S, Wettwer E, Dobrev D, Wallukat G, Ravens U. Effects of immunoglobulin G from patients with dilated cardiomyopathy on rat cardiomyocytes. Basic Clin Pharmacol Toxicol. 2005 Jun; 96(6):445-52. PMID: 15910408.
      View in: PubMed
    149. Vest JA, Wehrens XH, Reiken SR, Lehnart SE, Dobrev D, Chandra P, Danilo P, Ravens U, Rosen MR, Marks AR. Defective cardiac ryanodine receptor regulation during atrial fibrillation. Circulation. 2005 Apr 26; 111(16):2025-32. PMID: 15851612.
      View in: PubMed
    150. Frey UH, Nückel H, Dobrev D, Manthey I, Sandalcioglu IE, Eisenhardt A, Worm K, Hauner H, Siffert W. Quantification of G protein Gaalphas subunit splice variants in different human tissues and cells using pyrosequencing. Gene Expr. 2005; 12(2):69-81. PMID: 15892449.
      View in: PubMed
    151. Christ T, Rauwolf T, Braun M, Dobrev D, Ravens U, Strasser RH. Recording atrial monophasic action potentials using standard pacemaker leads: an alternative way to study electrophysiology properties of the human atrium in vivo? Pacing Clin Electrophysiol. 2004 Dec; 27(12):1632-7. PMID: 15613126.
      View in: PubMed
    152. Christ T, Wüst M, Matthes J, Jänchen M, Jürgens S, Herzig S, Wettwer E, Dobrev D, Matschke K, Mebs D, Ravens U. An aqueous extract of the marine sponge Ectyoplasia ferox stimulates L-type Ca2+-current by direct interaction with the Cav1.2 subunit. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec; 370(6):474-83. PMID: 15599709.
      View in: PubMed
    153. Wettwer E, Hála O, Christ T, Heubach JF, Dobrev D, Knaut M, Varró A, Ravens U. Role of IKur in controlling action potential shape and contractility in the human atrium: influence of chronic atrial fibrillation. Circulation. 2004 Oct 19; 110(16):2299-306. PMID: 15477405.
      View in: PubMed
    154. Dobrev D, Christ T, Ravens U. Muscarinic subtype-2 receptor autoantibodies: actors or bystanders in human atrial fibrillation? Eur Heart J. 2004 Jul; 25(13):1091-2. PMID: 15231365.
      View in: PubMed
    155. Schindler C, Dobrev D, Grossmann M, Francke K, Pittrow D, Kirch W. Mechanisms of beta-adrenergic receptor-mediated venodilation in humans. Clin Pharmacol Ther. 2004 Jan; 75(1):49-59. PMID: 14749691.
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    156. Balana B, Dobrev D, Wettwer E, Christ T, Knaut M, Ravens U. Decreased ATP-sensitive K(+) current density during chronic human atrial fibrillation. J Mol Cell Cardiol. 2003 Dec; 35(12):1399-405. PMID: 14654366.
      View in: PubMed
    157. Dobrev D. Transcription factors for ion channels: active or passive players in cardiac remodeling? Cardiovasc Res. 2003 Nov 1; 60(2):226-7. PMID: 14613850.
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    158. Dobrev D, Ravens U. Therapeutically relevant concentrations of neomycin selectively inhibit P-type Ca2+ channels in rat striatum. Eur J Pharmacol. 2003 Feb 14; 461(2-3):105-11. PMID: 12586205.
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    159. Ravens U, Dobrev D. Cardiac sympathetic innervation and control of potassium channel function. J Mol Cell Cardiol. 2003 Feb; 35(2):137-9. PMID: 12606253.
      View in: PubMed
    160. Christ T, Schier M, Brattström A, Muth G, Hartmann A, Dobrev D, Ravens U. Rate-adaptive pacing using intracardiac impedance shows no evidence for positive feedback during dobutamine stress test. Europace. 2002 Jul; 4(3):311-5. PMID: 12134978.
      View in: PubMed
    161. Dobrev D, Wettwer E, Kortner A, Knaut M, Schüler S, Ravens U. Human inward rectifier potassium channels in chronic and postoperative atrial fibrillation. Cardiovasc Res. 2002 May; 54(2):397-404. PMID: 12062344.
      View in: PubMed
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