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JAVIER JAVIER MEDINA

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Neuroscience
DivisionNeuroscience
AddressOne Baylor Plaza
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kamal KY, Herranz R, van Loon JJWA, Medina FJ. Simulated microgravity, Mars gravity, and 2g hypergravity affect cell cycle regulation, ribosome biogenesis, and epigenetics in Arabidopsis cell cultures. Sci Rep. 2018 Apr 23; 8(1):6424. PMID: 29686401.
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    2. Manzano A, Herranz R, den Toom LA, Te Slaa S, Borst G, Visser M, Medina FJ, van Loon JJWA. Novel, Moon and Mars, partial gravity simulation paradigms and their effects on the balance between cell growth and cell proliferation during early plant development. NPJ Microgravity. 2018; 4:9. PMID: 29644337.
      View in: PubMed
    3. Boucheron-Dubuisson E, Manzano AI, Le Disquet I, Matía I, Sáez-Vasquez J, van Loon JJ, Herranz R, Carnero-Diaz E, Medina FJ. Functional alterations of root meristematic cells of Arabidopsis thaliana induced by a simulated microgravity environment. J Plant Physiol. 2016 Dec 01; 207:30-41. PMID: 27792899.
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    4. Vandenbrink JP, Herranz R, Medina FJ, Edelmann RE, Kiss JZ. A novel blue-light phototropic response is revealed in roots of Arabidopsis thaliana in microgravity. Planta. 2016 Dec; 244(6):1201-1215. PMID: 27507239.
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    5. Kamal KY, Hemmersbach R, Medina FJ, Herranz R. Proper selection of 1 g controls in simulated microgravity research as illustrated with clinorotated plant cell suspension cultures. Life Sci Space Res (Amst). 2015 Apr; 5:47-52. PMID: 26177849.
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    6. Luque E, Ruz-Caracuel I, Medina FJ, Leiva-Cepas F, Agüera E, Sánchez-López F, Lillo R, Aguilar-Luque M, Jimena I, Túnez I, Peña J. Skeletal muscle findings in experimental autoimmune encephalomyelitis. Pathol Res Pract. 2015 Jul; 211(7):493-504. PMID: 25769878.
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    7. Herranz R, Valbuena MA, Manzano A, Kamal KY, Medina FJ. Use of microgravity simulators for plant biological studies. Methods Mol Biol. 2015; 1309:239-54. PMID: 25981780.
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    8. Mazars C, Brière C, Grat S, Pichereaux C, Rossignol M, Pereda-Loth V, Eche B, Boucheron-Dubuisson E, Le Disquet I, Medina FJ, Graziana A, Carnero-Diaz E. Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity. Plant Signal Behav. 2014 Jul 16; 9. PMID: 25029201.
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    9. Mazars C, Brière C, Grat S, Pichereaux C, Rossignol M, Pereda-Loth V, Eche B, Boucheron-Dubuisson E, Le Disquet I, Medina FJ, Graziana A, Carnero-Diaz E. Microgravity induces changes in microsome-associated proteins of Arabidopsis seedlings grown on board the international space station. PLoS One. 2014; 9(3):e91814. PMID: 24618597.
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    10. Herranz R, Valbuena MA, Youssef K, Medina FJ. Mechanisms of disruption of meristematic competence by microgravity in Arabidopsis seedlings. Plant Signal Behav. 2014; 9(3):e28289. PMID: 24614101.
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    11. Kittang AI, Iversen TH, Fossum KR, Mazars C, Carnero-Diaz E, Boucheron-Dubuisson E, Le Disquet I, Legué V, Herranz R, Pereda-Loth V, Medina FJ. Exploration of plant growth and development using the European Modular Cultivation System facility on the International Space Station. Plant Biol (Stuttg). 2014 May; 16(3):528-38. PMID: 24433330.
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    12. Mazars C, Brière C, Grat S, Pichereaux C, Rossignol M, Pereda-Loth V, Eche B, Boucheron-Dubuisson E, Le Disquet I, Medina FJ, Graziana A, Carnero-Diaz E. Microsome-associated proteome modifications of Arabidopsis seedlings grown on board the International Space Station reveal the possible effect on plants of space stresses other than microgravity. Plant Signal Behav. 2014; 9(9):e29637. PMID: 25763699.
      View in: PubMed
    13. Herranz R, Valbuena MA, Youssef K, Medina FJ. Mechanisms of disruption of meristematic competence by microgravity in Arabidopsis seedlings. Plant Signal Behav. 2014; 9(4):e28289. PMID: 25764425.
      View in: PubMed
    14. Medina FJ, Ciria R, Caro MT, Rufián S, Briceño J. Bright red line along the small bowel: a finding of eosinophilic gastroenteritis. ANZ J Surg. 2014 Sep; 84(9):684-5. PMID: 24165112.
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    15. Herranz R, Medina FJ. Cell proliferation and plant development under novel altered gravity environments. Plant Biol (Stuttg). 2014 Jan; 16 Suppl 1:23-30. PMID: 24112664.
      View in: PubMed
    16. Manzano AI, Larkin OJ, Dijkstra CE, Anthony P, Davey MR, Eaves L, Hill RJ, Herranz R, Medina FJ. Meristematic cell proliferation and ribosome biogenesis are decoupled in diamagnetically levitated Arabidopsis seedlings. BMC Plant Biol. 2013; 13:124. PMID: 24006876.
      View in: PubMed
    17. Herranz R, Larkin OJ, Hill RJ, Lopez-Vidriero I, van Loon JJ, Medina FJ. Suboptimal evolutionary novel environments promote singular altered gravity responses of transcriptome during Drosophila metamorphosis. BMC Evol Biol. 2013; 13:133. PMID: 23806134.
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    18. Herranz R, Manzano AI, van Loon JJ, Christianen PC, Medina FJ. Proteomic signature of Arabidopsis cell cultures exposed to magnetically induced hyper- and microgravity environments. Astrobiology. 2013 Mar; 13(3):217-24. PMID: 23510084.
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    19. Medina FJ, Túnez I. Mechanisms and pathways underlying the therapeutic effect of transcranial magnetic stimulation. Rev Neurosci. 2013; 24(5):507-25. PMID: 24077617.
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    20. Herranz R, Anken R, Boonstra J, Braun M, Christianen PC, de Geest M, Hauslage J, Hilbig R, Hill RJ, Lebert M, Medina FJ, Vagt N, Ullrich O, van Loon JJ, Hemmersbach R. Ground-based facilities for simulation of microgravity: organism-specific recommendations for their use, and recommended terminology. Astrobiology. 2013 Jan; 13(1):1-17. PMID: 23252378.
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    21. Tasset I, Pérez-Herrera A, Medina FJ, Arias-Carrión O, Drucker-Colín R, Túnez I. Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington's disease-like rat model. Brain Stimul. 2013 Jan; 6(1):84-6. PMID: 22537865.
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    22. Manzano AI, van Loon JJ, Christianen PC, Gonzalez-Rubio JM, Medina FJ, Herranz R. Gravitational and magnetic field variations synergize to cause subtle variations in the global transcriptional state of Arabidopsis in vitro callus cultures. BMC Genomics. 2012; 13:105. PMID: 22435851.
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    23. Tasset I, Medina FJ, Jimena I, Agüera E, Gascón F, Feijóo M, Sánchez-López F, Luque E, Peña J, Drucker-Colín R, Túnez I. Neuroprotective effects of extremely low-frequency electromagnetic fields on a Huntington's disease rat model: effects on neurotrophic factors and neuronal density. Neuroscience. 2012 May 3; 209:54-63. PMID: 22406415.
      View in: PubMed
    24. Herranz R, Larkin OJ, Dijkstra CE, Hill RJ, Anthony P, Davey MR, Eaves L, van Loon JJ, Medina FJ, Marco R. Microgravity simulation by diamagnetic levitation: effects of a strong gradient magnetic field on the transcriptional profile of Drosophila melanogaster. BMC Genomics. 2012; 13:52. PMID: 22296880.
      View in: PubMed
    25. Hill RJ, Larkin OJ, Dijkstra CE, Manzano AI, de Juan E, Davey MR, Anthony P, Eaves L, Medina FJ, Marco R, Herranz R. Effect of magnetically simulated zero-gravity and enhanced gravity on the walk of the common fruitfly. J R Soc Interface. 2012 Jul 7; 9(72):1438-49. PMID: 22219396.
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    26. Medina FJ, Callén CI, Rebolleda G, Muñoz-Negrete FJ, Callén MJ, del Valle FG. Use of nonmydriatic spectral-domain optical coherence tomography for diagnosing diabetic macular edema. Am J Ophthalmol. 2012 Mar; 153(3):536-543.e1. PMID: 21996307.
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    27. Pontvianne F, Abou-Ellail M, Douet J, Comella P, Matia I, Chandrasekhara C, Debures A, Blevins T, Cooke R, Medina FJ, Tourmente S, Pikaard CS, Sáez-Vásquez J. Nucleolin is required for DNA methylation state and the expression of rRNA gene variants in Arabidopsis thaliana. PLoS Genet. 2010 Nov; 6(11):e1001225. PMID: 21124873.
      View in: PubMed
    28. Tasset I, Drucker-Colín R, Peña J, Jimena I, Montilla P, Medina FJ, Túnez I. Antioxidant-like effects and protective action of transcranial magnetic stimulation in depression caused by olfactory bulbectomy. Neurochem Res. 2010 Aug; 35(8):1182-7. PMID: 20428940.
      View in: PubMed
    29. Medina FJ, Herranz R. Microgravity environment uncouples cell growth and cell proliferation in root meristematic cells: the mediator role of auxin. Plant Signal Behav. 2010 Feb; 5(2):176-9. PMID: 20173415.
      View in: PubMed
    30. Medina FJ, Túnez I. Huntington's disease: the value of transcranial meganetic stimulation. Curr Med Chem. 2010; 17(23):2482-91. PMID: 20491647.
      View in: PubMed
    31. Herrera-Esparza R, Medina F, Avalos-Díaz E. Tacrolimus therapy for circinate balanitis associated with reactive arthritis. J Clin Rheumatol. 2009 Dec; 15(8):377-9. PMID: 19955992.
      View in: PubMed
    32. de Melo IS, Iglesias C, Benítez-Rondán A, Medina F, Martínez-Barberá JP, Bolívar J. NOA36/ZNF330 is a conserved cystein-rich protein with proapoptotic activity in human cells. Biochim Biophys Acta. 2009 Dec; 1793(12):1876-85. PMID: 19895853.
      View in: PubMed
    33. Túnez I, Drucker-Colín R, Montilla P, Peña J, Jimena I, Medina FJ, Tasset I. Protective effect of nicotine on oxidative and cell damage in rats with depression induced by olfactory bulbectomy. Eur J Pharmacol. 2010 Feb 10; 627(1-3):115-8. PMID: 19887066.
      View in: PubMed
    34. Tasset I, Espínola C, Medina FJ, Feijóo M, Ruiz C, Moreno E, Gómez MM, Collado JA, Muñoz C, Muntané J, Montilla P, Túnez I. Neuroprotective effect of carvedilol and melatonin on 3-nitropropionic acid-induced neurotoxicity in neuroblastoma. J Physiol Biochem. 2009 Sep; 65(3):291-6. PMID: 20119823.
      View in: PubMed
    35. Marqués R, Jelinek L, Mesa F, Medina F. Analytical theory of wave propagation through stacked fishnet metamaterials. Opt Express. 2009 Jul 6; 17(14):11582-93. PMID: 19582074.
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    36. Marqués R, Mesa F, Jelinek L, Medina F. Analytical theory of extraordinary transmission through metallic diffraction screens perforated by small holes. Opt Express. 2009 Mar 30; 17(7):5571-9. PMID: 19333324.
      View in: PubMed
    37. Tasset I, Medina FJ, Peña J, Jimena I, Del Carmen Muñoz M, Salcedo M, Ruiz C, Feijóo M, Montilla P, Túnez I. Olfactory bulbectomy induced oxidative and cell damage in rat: protective effect of melatonin. Physiol Res. 2010; 59(1):105-12. PMID: 19249910.
      View in: PubMed
    38. Sobol MA, González-Camacho F, Kordyum EL, Medina FJ. Changes in the two-dimensional proteome of the soluble fraction of nuclear proteins from Lepidium sativum root meristematic cells grown under clinorotation. J Gravit Physiol. 2007 Jul; 14(1):P109-10. PMID: 18372723.
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    39. Marco R, Laván DA, van Loon JJ, Leandro LJ, Larkin OJ, Dijkstra C, Anthony P, Villa A, Davey MR, Lowe KC, Power JB, Medina FJ. Drosophila melanogaster, a model system for comparative studies on the responses to real and simulated microgravity. J Gravit Physiol. 2007 Jul; 14(1):P125-6. PMID: 18372731.
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    40. Herdes C, Valente A, Lin Z, Rocha J, Coutinho JA, Medina F, Vega LF. Selective adsorption of volatile organic compounds in micropore aluminum methylphosphonate-alpha: a combined molecular simulation-experimental approach. Langmuir. 2007 Jun 19; 23(13):7299-305. PMID: 17530785.
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    41. Leandro LJ, Szewczyk NJ, Benguría A, Herranz R, Laván D, Medina FJ, Gasset G, Loon JV, Conley CA, Marco R. Comparative analysis of Drosophila melanogaster and Caenorhabditis elegans gene expression experiments in the European Soyuz flights to the International Space Station. Adv Space Res. 2007 Apr; 40(4):506-512. PMID: 18084631.
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    42. Túnez I, Muñoz MC, Medina FJ, Salcedo M, Feijóo M, Montilla P. Comparison of melatonin, vitamin E and L-carnitine in the treatment of neuro- and hepatotoxicity induced by thioacetamide. Cell Biochem Funct. 2007 Mar-Apr; 25(2):119-27. PMID: 16245358.
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    43. Túnez I, Feijóo M, Collado JA, Medina FJ, Peña J, Muñoz Mdel C, Jimena I, Franco F, Rueda I, Muntané J, Montilla P. Effect of testosterone on oxidative stress and cell damage induced by 3-nitropropionic acid in striatum of ovariectomized rats. Life Sci. 2007 Mar 6; 80(13):1221-7. PMID: 17266993.
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    44. González-Camacho F, Medina FJ. Extraction of nuclear proteins from root meristematic cells. Methods Mol Biol. 2007; 355:63-72. PMID: 17093303.
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    45. Pontvianne F, Matía I, Douet J, Tourmente S, Medina FJ, Echeverria M, Sáez-Vásquez J. Characterization of AtNUC-L1 reveals a central role of nucleolin in nucleolus organization and silencing of AtNUC-L2 gene in Arabidopsis. Mol Biol Cell. 2007 Feb; 18(2):369-79. PMID: 17108323.
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    46. Sobol M, Gonzalez-Camacho F, Rodríguez-Vilariño V, Kordyum E, Medina FJ. Subnucleolar location of fibrillarin and NopA64 in Lepidium sativum root meristematic cells is changed in altered gravity. Protoplasma. 2006 Sep; 228(4):209-19. PMID: 16838080.
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    47. Túnez I, Montilla P, del Carmen Muñoz M, Medina FJ, Drucker-Colín R. Effect of transcranial magnetic stimulation on oxidative stress induced by 3-nitropropionic acid in cortical synaptosomes. Neurosci Res. 2006 Sep; 56(1):91-5. PMID: 16837092.
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    48. Túnez I, Collado JA, Medina FJ, Muñoz MC, Gordillo R, Sampedro C, Moyano MJ, Feijóo M, Muntané J, Montilla P. Protective effect of carvedilol on oxidative stress induced by okadaic acid in N1E-115 cells. Pharmacol Res. 2006 Sep; 54(3):241-6. PMID: 16829126.
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    49. Díez JL, Vilariño VR, Medina FJ, Morcillo G. Nucleolar localization of a reverse transcriptase related to telomere maintenance in Chironomus (Diptera). Histochem Cell Biol. 2006 Oct; 126(4):445-52. PMID: 16607537.
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    50. Túnez I, Drucker-Colín R, Jimena I, Medina FJ, Muñoz Mdel C, Peña J, Montilla P. Transcranial magnetic stimulation attenuates cell loss and oxidative damage in the striatum induced in the 3-nitropropionic model of Huntington's disease. J Neurochem. 2006 May; 97(3):619-30. PMID: 16524377.
      View in: PubMed
    51. Túnez I, Collado JA, Medina FJ, Peña J, Del C Muñoz M, Jimena I, Franco F, Rueda I, Feijóo M, Muntané J, Montilla P. 17 beta-Estradiol may affect vulnerability of striatum in a 3-nitropropionic acid-induced experimental model of Huntington's disease in ovariectomized rats. Neurochem Int. 2006 Apr; 48(5):367-73. PMID: 16420966.
      View in: PubMed
    52. González-Camacho F, Medina FJ. The nucleolar structure and the activity of NopA100, a nucleolin-like protein, during the cell cycle in proliferating plant cells. Histochem Cell Biol. 2006 Jan; 125(1-2):139-53. PMID: 16217651.
      View in: PubMed
    53. Herdes C, Santos MA, Medina F, Vega LF. Pore size distribution analysis of selected hexagonal mesoporous silicas by grand canonical Monte Carlo simulations. Langmuir. 2005 Sep 13; 21(19):8733-42. PMID: 16142955.
      View in: PubMed
    54. Túnez I, Muñoz MC, Villavicencio MA, Medina FJ, de Prado EP, Espejo I, Barcos M, Salcedo M, Feijóo M, Montilla P. Hepato- and neurotoxicity induced by thioacetamide: protective effects of melatonin and dimethylsulfoxide. Pharmacol Res. 2005 Sep; 52(3):223-8. PMID: 15896975.
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    55. Alvarez PM, García-Araya JF, Beltrán FJ, Masa FJ, Medina F. Ozonation of activated carbons: Effect on the adsorption of selected phenolic compounds from aqueous solutions. J Colloid Interface Sci. 2005 Mar 15; 283(2):503-12. PMID: 15721926.
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    56. Lería F, Marco R, Medina FJ. Structural and antigenic preservation of plant samples by microwave-enhanced fixation, using dedicated hardware, minimizing heat-related effects. Microsc Res Tech. 2004 Sep; 65(1-2):86-100. PMID: 15570593.
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    57. Sobol MA, Kordyum EL, Gonzalez-Camacho F, Rodríguez-Vilarino V, Medina FJ. Alterations of the intranucleolar DNA localization caused by simulated microgravity. J Gravit Physiol. 2004 Jul; 11(2):P189-90. PMID: 16237832.
      View in: PubMed
    58. Villapecellín-Cid MM, Medina F, Roa LM. Internodal myelinated segments: delay and RGC time-domain Green function model. IEEE Trans Biomed Eng. 2004 Feb; 51(2):389-91. PMID: 14765713.
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    59. González-Camacho F, Medina FJ. Identification of specific plant nucleolar phosphoproteins in a functional proteomic analysis. Proteomics. 2004 Feb; 4(2):407-17. PMID: 14760710.
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    60. Marco R, Husson D, Herranz R, Mateos J, Medina FJ. Drosophila melanogaster and the future of 'evo-devo' biology in space. Challenges and problems in the path of an eventual colonization project outside the earth. Adv Space Biol Med. 2003; 9:41-81. PMID: 14631629.
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    61. Marqués R, Martel J, Mesa F, Medina F. Left-handed-media simulation and transmission of EM waves in subwavelength split-ring-resonator-loaded metallic waveguides. Phys Rev Lett. 2002 Oct 28; 89(18):183901. PMID: 12398601.
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    62. Herranz R, Husson D, Pastor M, Diaz C, Mateos J, Villa A, Medina FJ, Marco R. Towards the establishment of a permanent colony of Drosophila in the International Space Station: hardware tests and adaptation of techniques. J Gravit Physiol. 2002 Jul; 9(1):P357-8. PMID: 15002613.
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    63. Medina FJ, Cogoli A, Franks F, Marco R, Marthy HJ, Martin-Pascual C, Kraemer J, Pastor M. Current topics on sample preservation. A report on the progress of the ESA Topical Team. Preservation of fixed and non-fixed samples during space experimentation. J Gravit Physiol. 2002 Jul; 9(1):P371-2. PMID: 15002619.
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    64. Scimonelli T, Medina F, Wilson C, Celis ME. Interaction of alpha-melanotropin (alpha-MSH) and noradrenaline in the median eminence in the control of female sexual behavior. Peptides. 2000 Feb; 21(2):219-23. PMID: 10764948.
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    65. Medina FJ, Cerdido A, de Cárcer G. The functional organization of the nucleolus in proliferating plant cells. Eur J Histochem. 2000; 44(2):117-31. PMID: 10968360.
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    66. de Carcer G, Medina FJ. Simultaneous localization of transcription and early processing markers allows dissection of functional domains in the plant cell nucleolus. J Struct Biol. 1999 Dec 15; 128(2):139-51. PMID: 10600568.
      View in: PubMed
    67. Medina F, Siddiqui A, Scimonelli T, Fenske C, Wilson CA, Celis ME. The inter-relationship between gonadal steroids and POMC peptides, beta-endorphin and alpha-MSH, in the control of sexual behavior in the female rat. Peptides. 1998; 19(8):1309-16. PMID: 9809644.
      View in: PubMed
    68. Medina F, Ayala A, Jara LJ, Becerra M, Miranda JM, Fraga A. Acute abdomen in systemic lupus erythematosus: the importance of early laparotomy. Am J Med. 1997 Aug; 103(2):100-5. PMID: 9274892.
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    69. de Cárcer G, Cerdido A, Medina FJ. NopA64, a novel nucleolar phosphoprotein from proliferating onion cells, sharing immunological determinants with mammalian nucleolin. Planta. 1997; 201(4):487-95. PMID: 9151450.
      View in: PubMed
    70. Medina FJ, Cerdido A, Fernández-Gómez ME. Components of the nucleolar processing complex (Pre-rRNA, fibrillarin, and nucleolin) colocalize during mitosis and are incorporated to daughter cell nucleoli. Exp Cell Res. 1995 Nov; 221(1):111-25. PMID: 7589236.
      View in: PubMed
    71. Medina F, Fuentes M, Jara LJ, Barile L, Miranda JM, Fraga A. Salmonella pyomyositis in patients with the human immunodeficiency virus. Br J Rheumatol. 1995 Jun; 34(6):568-71. PMID: 7633800.
      View in: PubMed
    72. Medina FJ, Cerdido A, Marco R. Microwave irradiation improvements in the silver staining of the nucleolar organizer (Ag-NOR) technique. Histochem Cell Biol. 1995 Jun; 103(6):403-13. PMID: 7584547.
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    73. Cerdido A, Medina FJ. Subnucleolar location of fibrillarin and variation in its levels during the cell cycle and during differentiation of plant cells. Chromosoma. 1995 May; 103(9):625-34. PMID: 7587585.
      View in: PubMed
    74. Medina FJ, Cerdido A, Maroto M, Manzanares M, Marco R. Enhancement of the immunocytochemical detection of antigens by microwave irradiation. Benefits and limitations analysed in isolated plant nuclei and Drosophila embryos in toto. Histochemistry. 1994 Aug; 102(1):45-50. PMID: 7814269.
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    75. Martin M, Medina FJ. A Drosophila anti-RNA polymerase II antibody recognizes a plant nucleolar antigen, RNA polymerase I, which is mostly localized in fibrillar centres. J Cell Sci. 1991 Sep; 100 ( Pt 1):99-107. PMID: 1795033.
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    76. Medina FJ. The nucleolus, in the spotlight. Meeting on the nucleolus, Toledo (Spain), December 15-18, 1988. Eur J Cell Biol. 1989 Oct; 50(1):244-6. PMID: 2612501.
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    77. Medina F, Fraga A, Lavalle C. Salmonella septic arthritis in systemic lupus erythematosus. The importance of chronic carrier state. J Rheumatol. 1989 Feb; 16(2):203-8. PMID: 2664165.
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    78. Risueño MC, Medina FJ. The nucleolar structure in plant cells. Revis Biol Celular. 1986; 7:1-154. PMID: 2447615.
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    79. Risueño MC, Medina FJ, Moreno Díaz de la Espina S. Nucleolar fibrillar centres in plant meristematic cells: ultrastructure, cytochemistry and autoradiography. J Cell Sci. 1982 Dec; 58:313-29. PMID: 7183690.
      View in: PubMed
    80. Morena-Días de la Espina S, Medina FJ, Risueño MC. Correlation of nucleolar activity and nucleolar vacuolation in plant cells. Eur J Cell Biol. 1980 Oct; 22(2):724-9. PMID: 6450047.
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