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TitleAssistant Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPark Road 1C P. O. Box 389
Smithville TX 78957
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chatterjee N, Lin Y, Santillan BA, Yotnda P, Wilson JH. Environmental stress induces trinucleotide repeat mutagenesis in human cells. Proc Natl Acad Sci U S A. 2015 Mar 24; 112(12):3764-9. PMID: 25775519; PMCID: PMC4378418.
    2. Lin WY, Lin Y, Wilson JH. Convergent transcription through microsatellite repeat tracts induces cell death. Mol Biol Rep. 2014 Sep; 41(9):5627-34. PMID: 25012912.
      View in: PubMed
    3. Bhattacharjee V, Lin Y, Waldman BC, Waldman AS. Induction of recombination between diverged sequences in a mammalian genome by a double-strand break. Cell Mol Life Sci. 2014 Jun; 71(12):2359-71. PMID: 24257896.
      View in: PubMed
    4. Lin WY, Wilson JH, Lin Y. Repair of chromosomal double-strand breaks by precise ligation in human cells. DNA Repair (Amst). 2013 Jul; 12(7):480-7. PMID: 23707303; PMCID: PMC3736570.
    5. Lin Y, Wilson JH. Nucleotide excision repair, mismatch repair, and R-loops modulate convergent transcription-induced cell death and repeat instability. PLoS One. 2012; 7(10):e46807. PMID: 23056461; PMCID: PMC3463551.
    6. Hubert L, Lin Y, Dion V, Wilson JH. Xpa deficiency reduces CAG trinucleotide repeat instability in neuronal tissues in a mouse model of SCA1. Hum Mol Genet. 2011 Dec 15; 20(24):4822-30. PMID: 21926083; PMCID: PMC3221534.
    7. Hubert L, Lin Y, Dion V, Wilson JH. Topoisomerase 1 and single-strand break repair modulate transcription-induced CAG repeat contraction in human cells. Mol Cell Biol. 2011 Aug; 31(15):3105-12. PMID: 21628532; PMCID: PMC3147608.
    8. Lin Y, Wilson JH. Transcription-induced DNA toxicity at trinucleotide repeats: double bubble is trouble. Cell Cycle. 2011 Feb 15; 10(4):611-8. PMID: 21293182; PMCID: PMC3173998.
    9. Lin Y, Leng M, Wan M, Wilson JH. Convergent transcription through a long CAG tract destabilizes repeats and induces apoptosis. Mol Cell Biol. 2010 Sep; 30(18):4435-51. PMID: 20647539; PMCID: PMC2937530.
    10. Mittelman D, Sykoudis K, Hersh M, Lin Y, Wilson JH. Hsp90 modulates CAG repeat instability in human cells. Cell Stress Chaperones. 2010 Sep; 15(5):753-9. PMID: 20373063; PMCID: PMC3006633.
    11. Lin Y, Dent SY, Wilson JH, Wells RD, Napierala M. R loops stimulate genetic instability of CTG.CAG repeats. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):692-7. PMID: 20080737; PMCID: PMC2818888.
    12. Chen Z, Lin Y, Barbieri E, Burlingame S, Hicks J, Ludwig A, Shohet JM. Mdm2 deficiency suppresses MYCN-Driven neuroblastoma tumorigenesis in vivo. Neoplasia. 2009 Aug; 11(8):753-62. PMID: 19649205; PMCID: PMC2713395.
    13. Lin Y, Wilson JH. Diverse effects of individual mismatch repair components on transcription-induced CAG repeat instability in human cells. DNA Repair (Amst). 2009 Aug 06; 8(8):878-85. PMID: 19497791; PMCID: PMC3671857.
    14. Mittelman D, Moye C, Morton J, Sykoudis K, Lin Y, Carroll D, Wilson JH. Zinc-finger directed double-strand breaks within CAG repeat tracts promote repeat instability in human cells. Proc Natl Acad Sci U S A. 2009 Jun 16; 106(24):9607-12. PMID: 19482946; PMCID: PMC2701052.
    15. Lin Y, Hubert L, Wilson JH. Transcription destabilizes triplet repeats. Mol Carcinog. 2009 Apr; 48(4):350-61. PMID: 18973172; PMCID: PMC3671855.
    16. Dion V, Lin Y, Hubert L, Waterland RA, Wilson JH. Dnmt1 deficiency promotes CAG repeat expansion in the mouse germline. Hum Mol Genet. 2008 May 01; 17(9):1306-17. PMID: 18252747; PMCID: PMC3686304.
    17. Dion V, Lin Y, Price BA, Fyffe SL, Seluanov A, Gorbunova V, Wilson JH. Genome-wide demethylation promotes triplet repeat instability independently of homologous recombination. DNA Repair (Amst). 2008 Feb 01; 7(2):313-20. PMID: 18083071; PMCID: PMC2235822.
    18. Lin Y, Wilson JH. Transcription-induced CAG repeat contraction in human cells is mediated in part by transcription-coupled nucleotide excision repair. Mol Cell Biol. 2007 Sep; 27(17):6209-17. PMID: 17591697; PMCID: PMC1952160.
    19. Yang D, Goldsmith EB, Lin Y, Waldman BC, Kaza V, Waldman AS. Genetic exchange between homeologous sequences in mammalian chromosomes is averted by local homology requirements for initiation and resolution of recombination. Genetics. 2006 Sep; 174(1):135-44. PMID: 16816418; PMCID: PMC1569803.
    20. Lin Y, Dion V, Wilson JH. Transcription promotes contraction of CAG repeat tracts in human cells. Nat Struct Mol Biol. 2006 Feb; 13(2):179-80. PMID: 16388310.
      View in: PubMed
    21. Lin Y, Dion V, Wilson JH. A novel selectable system for detecting expansion of CAG.CTG repeats in mammalian cells. Mutat Res. 2005 May 02; 572(1-2):123-31. PMID: 15790495.
      View in: PubMed
    22. Lin Y, Waldman BC, Waldman AS. Suppression of high-fidelity double-strand break repair in mammalian chromosomes by pifithrin-alpha, a chemical inhibitor of p53. DNA Repair (Amst). 2003 Jan 02; 2(1):1-11. PMID: 12509264.
      View in: PubMed
    23. Lin Y, Waldman AS. Promiscuous patching of broken chromosomes in mammalian cells with extrachromosomal DNA. Nucleic Acids Res. 2001 Oct 01; 29(19):3975-81. PMID: 11574679.
      View in: PubMed
    24. Lin Y, Waldman AS. Capture of DNA sequences at double-strand breaks in mammalian chromosomes. Genetics. 2001 Aug; 158(4):1665-74. PMID: 11514454; PMCID: PMC1461771.
    25. Lin Y, Lukacsovich T, Waldman AS. Multiple pathways for repair of DNA double-strand breaks in mammalian chromosomes. Mol Cell Biol. 1999 Dec; 19(12):8353-60. PMID: 10567560; PMCID: PMC84924.
    26. Transcription and triplet repeat instability. 691-704.
    27. Environmental Stress Induces Trinucleotide Repeat Mutagenesis in Human Cells by Alt-Nonhomologous End Joining Repair. Journal of Molecular Biology. 428:2978-2980.
    28. Mismatch repair enhances convergent transcription-induced cell death at trinucleotide repeats by activating ATR. DNA Repair. 42:26-32.
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