TitleAssistant Professor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bushnell GG, Deshmukh AP, den Hollander P, Luo M, Soundararajan R, Jia D, Levine H, Mani SA, Wicha MS. Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge. NPJ Breast Cancer. 2021 May 28; 7(1):66. PMID: 34050189.
    2. Deshmukh AP, Vasaikar SV, Tomczak K, Tripathi S, den Hollander P, Arslan E, Chakraborty P, Soundararajan R, Jolly MK, Rai K, Levine H, Mani SA. Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2021 May 11; 118(19). PMID: 33941680.
      Citations:    Fields:    
    3. Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 Jul; 125(2):176-189. PMID: 33795809.
      Citations:    Fields:    
    4. Sidramagowda Patil S, Hernández-Cuervo H, Fukumoto J, Krishnamurthy S, Lin M, Alleyn M, Breitzig M, Narala VR, Soundararajan R, Lockey RF, Kolliputi N, Galam L. Alda-1 Attenuates Hyperoxia-Induced Acute Lung Injury in Mice. Front Pharmacol. 2020; 11:597942. PMID: 33597876.
      Citations: 1     
    5. Vasaikar SV, Deshmukh AP, den Hollander P, Addanki S, Kuburich NA, Kudaravalli S, Joseph R, Chang JT, Soundararajan R, Mani SA. EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures. Br J Cancer. 2021 01; 124(1):259-269. PMID: 33299129.
      Citations: 2     Fields:    Translation:HumansCells
    6. Ramirez-Peña E, Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z, Matés JM, Márquez J, Chang JT, Vasaikar S, Soundararajan R, Sreekumar A, Mani SA. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression. Cancers (Basel). 2019 Oct 22; 11(10). PMID: 31652551.
      Citations: 12     
    7. Patil SS, Hernández-Cuervo H, Fukumoto J, Narala VR, Saji S, Borra M, Alleyn M, Lin M, Soundararajan R, Lockey R, Kolliputi N, Galam L. Alda-1 attenuates hyperoxia-induced mitochondrial dysfunction in lung vascular endothelial cells. Aging (Albany NY). 2019 06 17; 11(12):3909-3918. PMID: 31209184.
      Citations: 3     Fields:    Translation:HumansCells
    8. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625.
      Citations: 31     
    9. Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Pietila M, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA. GSK3ß regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 03 07; 21(1):37. PMID: 30845991.
      Citations: 21     Fields:    Translation:HumansCells
    10. Fukumoto J, Sidramagowda Patil S, Krishnamurthy S, Saji S, John I, Narala VR, Hernández-Cuervo H, Alleyn M, Breitzig MT, Galam L, Soundararajan R, Chaudhari UK, Hansen BC, Lockey RF, Kolliputi N. Altered expression of p63 isoforms and expansion of p63- and club cell secretory protein-positive epithelial cells in the lung as novel features of aging. Am J Physiol, Cell Physiol. 2019 04 01; 316(4):C492-C508. PMID: 30649915.
      Citations: 2     Translation:HumansAnimalsCells
    11. Fukumoto J, Leung J, Cox R, Czachor A, Parthasarathy PT, Lagishetty V, Mandry M, Hosseinian N, Patel P, Perry B, Breitzig MT, Alleyn M, Failla A, Cho Y, Cooke AJ, Galam L, Soundararajan R, Sharma N, Lockey RF, Kolliputi N. Oxidative stress induces club cell proliferation and pulmonary fibrosis in Atp8b1 mutant mice. Aging (Albany NY). 2019 01 13; 11(1):209-229. PMID: 30636723.
      Citations: 2     Fields:    Translation:AnimalsCells
    12. Soundararajan R, Paranjape AN, Maity S, Aparicio A, Mani SA. EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. Biochim Biophys Acta Rev Cancer. 2018 12; 1870(2):229-238. PMID: 29981816.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    13. Soundararajan R, Aparicio AM, Logothetis CJ, Mani SA, Maity SN. Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Front Oncol. 2018; 8:69. PMID: 29600194.
      Citations: 4     
    14. Narala VR, Fukumoto J, Hernández-Cuervo H, Patil SS, Krishnamurthy S, Breitzig M, Galam L, Soundararajan R, Lockey RF, Kolliputi N. Akap1 genetic deletion increases the severity of hyperoxia-induced acute lung injury in mice. Am J Physiol Lung Cell Mol Physiol. 2018 05 01; 314(5):L860-L870. PMID: 29388469.
      Citations: 11     Translation:AnimalsCells
    15. Bollong MJ, Pietilä M, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9903-E9912. PMID: 29087350.
      Citations: 18     Fields:    Translation:HumansCells
    16. Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017 Sep 12; 8(39):65548-65565. PMID: 29029452.
      Citations: 14     Fields:    
    17. Fukumoto J, Soundararajan R, Leung J, Cox R, Mahendrasah S, Muthavarapu N, Herrin T, Czachor A, Tan LC, Hosseinian N, Patel P, Gone J, Breitzig MT, Cho Y, Cooke AJ, Galam L, Narala VR, Pathak Y, Lockey RF, Kolliputi N. The role of club cell phenoconversion and migration in idiopathic pulmonary fibrosis. Aging (Albany NY). 2016 11 29; 8(11):3091-3109. PMID: 27899769.
      Citations: 8     Fields:    Translation:HumansCells
    18. Soundararajan R, Stearns TM, Czachor A, Fukumoto J, Turn C, Westermann-Clark E, Breitzig M, Tan L, Lockey RF, King BL, Kolliputi N. Global gene profiling of aging lungs in Atp8b1 mutant mice. Aging (Albany NY). 2016 09 29; 8(9):2232-2252. PMID: 27689529.
      Citations: 4     Fields:    Translation:AnimalsCells
    19. Galam L, Soundararajan R, Breitzig M, Rajan A, Yeruva RR, Czachor A, Harris F, Lockey RF, Kolliputi N. SOCS-1 rescues IL-1ß-mediated suppression of epithelial sodium channel in mouse lung epithelial cells via ASK-1. Oncotarget. 2016 May 17; 7(20):29081-91. PMID: 27058411.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Pietilä M, Vijay GV, Soundararajan R, Yu X, Symmans WF, Sphyris N, Mani SA. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Sci Rep. 2016 Apr 11; 6:23070. PMID: 27064522.
      Citations: 6     Fields:    Translation:HumansCells
    21. Galam L, Rajan A, Failla A, Soundararajan R, Lockey RF, Kolliputi N. Deletion of P2X7 attenuates hyperoxia-induced acute lung injury via inflammasome suppression. Am J Physiol Lung Cell Mol Physiol. 2016 Mar 15; 310(6):L572-81. PMID: 26747786.
      Citations: 21     Translation:AnimalsCells
    22. Galam L, Failla A, Soundararajan R, Lockey RF, Kolliputi N. 4-hydroxynonenal regulates mitochondrial function in human small airway epithelial cells. Oncotarget. 2015 Dec 08; 6(39):41508-21. PMID: 26484418.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Snyder E, Soundararajan R, Sharma M, Dearth A, Smith B, Braun RE. Compound Heterozygosity for Y Box Proteins Causes Sterility Due to Loss of Translational Repression. PLoS Genet. 2015 Dec; 11(12):e1005690. PMID: 26646932.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Soundararajan R, Stearns TM, Griswold AL, Mehta A, Czachor A, Fukumoto J, Lockey RF, King BL, Kolliputi N. Detection of canonical A-to-G editing events at 3' UTRs and microRNA target sites in human lungs using next-generation sequencing. Oncotarget. 2015 Nov 03; 6(34):35726-36. PMID: 26486088.
      Citations: 7     Fields:    Translation:HumansCells
    25. Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Sci Rep. 2015 Jun 30; 5:11766. PMID: 26123483.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    26. Soundararajan R, Won J, Stearns TM, Charette JR, Hicks WL, Collin GB, Naggert JK, Krebs MP, Nishina PM. Gene profiling of postnatal Mfrprd6 mutant eyes reveals differential accumulation of Prss56, visual cycle and phototransduction mRNAs. PLoS One. 2014; 9(10):e110299. PMID: 25357075.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    27. Naswa N, Karunanithi S, Sharma P, Soundararajan R, Bal C, Kumar R. Pre-operative 68Ga-DOTANOC somatostatin receptor PET/CT imaging demonstrating multiple synchronous lesions in a patient with head and neck paraganglioma. Rev Esp Med Nucl Imagen Mol. 2014 Nov-Dec; 33(6):374-7. PMID: 25043773.
      Citations: 3     Fields:    Translation:Humans
    28. Pearce D, Soundararajan R, Trimpert C, Kashlan OB, Deen PM, Kohan DE. Collecting duct principal cell transport processes and their regulation. Clin J Am Soc Nephrol. 2015 Jan 07; 10(1):135-46. PMID: 24875192.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    29. Soundararajan R, Ziera T, Koo E, Ling K, Wang J, Borden SA, Pearce D. Scaffold protein connector enhancer of kinase suppressor of Ras isoform 3 (CNK3) coordinates assembly of a multiprotein epithelial sodium channel (ENaC)-regulatory complex. J Biol Chem. 2012 Sep 21; 287(39):33014-25. PMID: 22851176.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    30. Soundararajan R, Prabha P, Rai U, Dixit A. Antileukemic Potential of Momordica charantia Seed Extracts on Human Myeloid Leukemic HL60 Cells. Evid Based Complement Alternat Med. 2012; 2012:732404. PMID: 22654956.
      Citations: 7     
    31. Suarez PE, Rodriguez EG, Soundararajan R, Mérillat AM, Stehle JC, Rotman S, Roger T, Voirol MJ, Wang J, Gross O, Pétrilli V, Nadra K, Wilson A, Beermann F, Pralong FP, Maillard M, Pearce D, Chrast R, Rossier BC, Hummler E. The glucocorticoid-induced leucine zipper (gilz/Tsc22d3-2) gene locus plays a crucial role in male fertility. Mol Endocrinol. 2012 Jun; 26(6):1000-13. PMID: 22556341.
      Citations: 15     Fields:    Translation:AnimalsCells
    32. Soundararajan R, Lu M, Pearce D. Organization of the ENaC-regulatory machinery. Crit Rev Biochem Mol Biol. 2012 Jul-Aug; 47(4):349-59. PMID: 22506713.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    33. Soundararajan R, Pearce D, Ziera T. The role of the ENaC-regulatory complex in aldosterone-mediated sodium transport. Mol Cell Endocrinol. 2012 Mar 24; 350(2):242-7. PMID: 22101317.
      Citations: 15     Fields:    Translation:HumansAnimals
    34. Soundararajan R, Wang J, Melters D, Pearce D. Glucocorticoid-induced Leucine zipper 1 stimulates the epithelial sodium channel by regulating serum- and glucocorticoid-induced kinase 1 stability and subcellular localization. J Biol Chem. 2010 Dec 17; 285(51):39905-13. PMID: 20947508.
      Citations: 16     Fields:    Translation:HumansCells
    35. Soundararajan R, Pearce D, Hughey RP, Kleyman TR. Role of epithelial sodium channels and their regulators in hypertension. J Biol Chem. 2010 Oct 01; 285(40):30363-9. PMID: 20624922.
      Citations: 53     Fields:    Translation:HumansAnimals
    36. Soundararajan R, Sayat R, Robertson GS, Marignani PA. Triptolide: An inhibitor of a disintegrin and metalloproteinase 10 (ADAM10) in cancer cells. Cancer Biol Ther. 2009 Nov; 8(21):2054-62. PMID: 19783906.
      Citations: 17     Translation:HumansCells
    37. Neelima PS, Rao Rekha M, Rama S, Rao AJ. Effect of human telomerase reverse transcriptase transfection on differentiation in BeWo choriocarcinoma cells. Reprod Biomed Online. 2009 Jun; 18(6):838-49. PMID: 19490790.
      Citations:    Fields:    Translation:HumansCells
    38. Soundararajan R, Melters D, Shih IC, Wang J, Pearce D. Epithelial sodium channel regulated by differential composition of a signaling complex. Proc Natl Acad Sci U S A. 2009 May 12; 106(19):7804-9. PMID: 19380724.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    39. Soundararajan R, Wishart AD, Rupasinghe HP, Arcellana-Panlilio M, Nelson CM, Mayne M, Robertson GS. Quercetin 3-glucoside protects neuroblastoma (SH-SY5Y) cells in vitro against oxidative damage by inducing sterol regulatory element-binding protein-2-mediated cholesterol biosynthesis. J Biol Chem. 2008 Jan 25; 283(4):2231-45. PMID: 18032389.
      Citations: 18     Fields:    Translation:HumansCells
    40. Soundararajan R, Wang J, Melters D, Pearce D. Differential activities of glucocorticoid-induced leucine zipper protein isoforms. J Biol Chem. 2007 Dec 14; 282(50):36303-13. PMID: 17956870.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    41. Pao AC, McCormick JA, Li H, Siu J, Govaerts C, Bhalla V, Soundararajan R, Pearce D. NH2 terminus of serum and glucocorticoid-regulated kinase 1 binds to phosphoinositides and is essential for isoform-specific physiological functions. Am J Physiol Renal Physiol. 2007 Jun; 292(6):F1741-50. PMID: 17356130.
      Citations: 19     Fields:    Translation:AnimalsCells
    42. Bhalla V, Soundararajan R, Pao AC, Li H, Pearce D. Disinhibitory pathways for control of sodium transport: regulation of ENaC by SGK1 and GILZ. Am J Physiol Renal Physiol. 2006 Oct; 291(4):F714-21. PMID: 16720863.
      Citations: 37     Fields:    Translation:HumansAnimals
    43. Yashwanth R, Rama S, Anbalagan M, Rao AJ. Role of estrogen in regulation of cellular differentiation: a study using human placental and rat Leydig cells. Mol Cell Endocrinol. 2006 Feb 26; 246(1-2):114-20. PMID: 16413111.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    44. Soundararajan R, Zhang TT, Wang J, Vandewalle A, Pearce D. A novel role for glucocorticoid-induced leucine zipper protein in epithelial sodium channel-mediated sodium transport. J Biol Chem. 2005 Dec 02; 280(48):39970-81. PMID: 16216878.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    45. Rama S, Petrusz P, Rao AJ. Hormonal regulation of human trophoblast differentiation: a possible role for 17beta-estradiol and GnRH. Mol Cell Endocrinol. 2004 Apr 15; 218(1-2):79-94. PMID: 15130513.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    46. Soundararajan R, Rao AJ. Trophoblast 'pseudo-tumorigenesis': significance and contributory factors. Reprod Biol Endocrinol. 2004 Mar 25; 2:15. PMID: 15043753.
      Citations: 53     Fields:    Translation:HumansCells
    47. Hamil KG, Liu Q, Sivashanmugam P, Anbalagan M, Yenugu S, Soundararajan R, Grossman G, Rao AJ, Birse CE, Ruben SM, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. LCN6, a novel human epididymal lipocalin. Reprod Biol Endocrinol. 2003 Nov 14; 1:112. PMID: 14617364.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    48. Rama S, Rao AJ. Regulation of growth and function of the human placenta. Mol Cell Biochem. 2003 Nov; 253(1-2):263-8. PMID: 14619978.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    49. Rao RM, Rama S, Rao AJ. Changes in T-plastin expression with human trophoblast differentiation. Reprod Biomed Online. 2003 Sep; 7(2):235-42. PMID: 14567899.
      Citations: 1     Fields:    Translation:HumansCells
    50. Rama S, Suresh Y, Rao AJ. TGF beta1 induces multiple independent signals to regulate human trophoblastic differentiation: mechanistic insights. Mol Cell Endocrinol. 2003 Aug 29; 206(1-2):123-36. PMID: 12943995.
      Citations: 7     Fields:    Translation:HumansCells
    51. Hamil KG, Liu Q, Sivashanmugam P, Yenugu S, Soundararajan R, Grossman G, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. Cystatin 11: a new member of the cystatin type 2 family. Endocrinology. 2002 Jul; 143(7):2787-96. PMID: 12072414.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    52. Liu Q, Hamil KG, Sivashanmugam P, Grossman G, Soundararajan R, Rao AJ, Richardson RT, Zhang YL, O'Rand MG, Petrusz P, French FS, Hall SH. Primate epididymis-specific proteins: characterization of ESC42, a novel protein containing a trefoil-like motif in monkey and human. Endocrinology. 2001 Oct; 142(10):4529-39. PMID: 11564719.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    53. Rama S, Suresh Y, Rao AJ. Regulation of telomerase during human placental differentiation: a role for TGFbeta1. Mol Cell Endocrinol. 2001 Sep; 182(2):233-48. PMID: 11514058.
      Citations: 12     Fields:    Translation:HumansCells
    54. Rama S, Rao AJ. Embryo implantation and GnRH antagonists: the search for the human placental GnRH receptor. Hum Reprod. 2001 Feb; 16(2):201-5. PMID: 11157806.
      Citations: 1     Fields:    Translation:HumansCells
    55. Vittal JP, Anantasubramaniam CR, Soundararajan R, Patil KC. Hydrazinium thiocyanate as a reagent for determination of copper. Talanta. 1979 Nov; 26(11):1041-2. PMID: 18962574.
      Citations:    Fields:    
    56. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
    57. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Scientific Reports. 6.
    58. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene.
    59. Effects of ICI 182780 on estrogen receptor expression, fluid absorption and sperm motility in the epididymis of the bonnet monkey. Reproductive Biology and Endocrinology. 3.
    60. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Scientific Reports. 5.
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