BARBARA JANE O'BRIEN

TitleAssistant Professor
InstitutionMD Anderson
DepartmentNeuro-Oncology
Address1400 Holcombe Blvd
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wilcox JA, Chukwueke UN, Ahn MJ, Aizer AA, Bale TA, Brandsma D, Brastianos PK, Chang S, Daras M, Forsyth P, Garzia L, Glantz M, Oliva ICG, Kumthekar P, Le Rhun E, Nagpal S, O'Brien B, Pentsova E, Lee EQ, Remsik J, Rud? R, Smalley I, Taylor MD, Weller M, Wefel J, Yang JT, Young RJ, Wen PY, Boire AA, International Leptomeningeal Metastasis Collaborative. Leptomeningeal metastases from solid tumors: A SNO and ASCO consensus review on clinical management and future directions. Neuro Oncol. 2024 Jun 21. PMID: 38902944.
      Citations:    Fields:    
    2. Pabon CM, Yeboa DN, O'Brien BJ, Majd NK, Wang C, Blum Murphy MA. Intrathecal topotecan with systemic checkpoint inhibitor therapy for gastroesophageal cancer with leptomeningeal involvement: two case reports and review of the literature. J Gastrointest Oncol. 2024 Jun 30; 15(3):1331-1340. PMID: 38989402; PMCID: PMC11231862.
      Citations:    
    3. Glitza Oliva IC, Ferguson SD, Bassett R, Foster AP, John I, Hennegan TD, Rohlfs M, Richard J, Iqbal M, Dett T, Lacey C, Jackson N, Rodgers T, Phillips S, Duncan S, Haydu L, Lin R, Amaria RN, Wong MK, Diab A, Yee C, Patel SP, McQuade JL, Fischer GM, McCutcheon IE, O'Brien BJ, Tummala S, Debnam M, Guha-Thakurta N, Wargo JA, Carapeto FCL, Hudgens CW, Huse JT, Tetzlaff MT, Burton EM, Tawbi HA, Davies MA. Author Correction: Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results. Nat Med. 2024 Jun; 30(6):1787. PMID: 38649781; PMCID: PMC11186776.
      Citations:    Fields:    
    4. Pham LC, Weller L, Gann CN, Schumacher KM, Vlassak S, Swanson T, Highsmith K, O'Brien BJ, Nash S, Aaroe A, de Groot JF, Majd NK. Prolonged complete response to adjuvant tepotinib in a patient with newly diagnosed disseminated glioblastoma harboring mesenchymal-epithelial transition fusion. Oncologist. 2024 May 30. PMID: 38815166.
      Citations:    Fields:    
    5. Kumar VA, Perez A, Young AL, Jones J, O'Brien BJ, Lang FF, Huse JT, Fuller GN. Collision tumor: Multinodular and vacuolating neuronal tumor with isocitrate dehydrogenase-mutant diffuse astrocytoma. Neuropathology. 2024 Feb 27. PMID: 38414131.
      Citations:    Fields:    
    6. Harrison RA, Tang M, Shih KK, Khan M, Pham L, De Moraes AR, O'Brien BJ, Bassett R, Bruera E. Characterization of patients with brain metastases referred to palliative care. BMC Palliat Care. 2024 Jan 11; 23(1):13. PMID: 38212765; PMCID: PMC10782691.
      Citations:    Fields:    Translation:Humans
    7. Singh AP, Xiao L, O'Brien BJ, Blondeau CE, Flowers CR, Bruera E, Morris VK, Shah AY. Association of Emotional Exhaustion With Career Burnout Among Early-Career Medical Oncologists: A Single-Institution Study. JCO Oncol Pract. 2024 01; 20(1):137-144. PMID: 37235818.
      Citations:    Fields:    Translation:Humans
    8. Glitza Oliva IC, Ferguson SD, Bassett R, Foster AP, John I, Hennegan TD, Rohlfs M, Richard J, Iqbal M, Dett T, Lacey C, Jackson N, Rodgers T, Phillips S, Duncan S, Haydu L, Lin R, Amaria RN, Wong MK, Diab A, Yee C, Patel SP, McQuade JL, Fischer GM, McCutcheon IE, O'Brien BJ, Tummala S, Debnam M, Guha-Thakurta N, Wargo JA, Burton EM, Tawbi HA, Davies MA, Carapeto FCL, Hudgens CW, Huse JT, Tetzlaff MT. Concurrent intrathecal and intravenous nivolumab in leptomeningeal disease: phase 1 trial interim results. Nat Med. 2023 04; 29(4):898-905. PMID: 36997799; PMCID: PMC10115650.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    9. Ozkizilkaya HI, Johnson JM, O'Brien BJ, McCutcheon IE, Prabhu SS, Ghia AJ, Fuller GN, Huse JT, Ballester LY. Intracranial mesenchymal tumor, FET::CREB fusion-positive in the lateral ventricle. Neurooncol Adv. 2023 Jan-Dec; 5(1):vdad026. PMID: 37051329; PMCID: PMC10084497.
      Citations:    
    10. Le Rhun E, Devos P, Winklhofer S, Lmalem H, Brandsma D, Kumthekar P, Castellano A, Compter A, Dhermain F, Franceschi E, Forsyth P, Furtner J, Galldiks N, Gempt J, Hattingen E, Lukacova S, Minniti G, O'Brien B, Postma TJ, Roth P, Schaefer N, Schmidt NO, Snijders TJ, Thust S, van den Bent M, van der Hoorn A, Smits M, Tonn JC, Jaeckle KA, Preusser M, Glantz M, Wen PY, Bendszus M, Weller M, G?llego P?rez-Larraya J, Hempel JM, Rud? R, Vogin G. Prospective validation of a new imaging scorecard to assess leptomeningeal metastasis: A joint EORTC BTG and RANO effort. Neuro Oncol. 2022 10 03; 24(10):1726-1735. PMID: 35157772; PMCID: PMC9527515.
      Citations:    Fields:    
    11. Upadhyay R, Khose S, Pokhylevych H, Paulino AC, McAleer MF, Ghia A, Li J, Yeboa DN, Loghin M, Harrison R, O'Brien B, Kamiya-Matsuoka C, De Groot J, Puduvalli VK, Tatsui C, Alvarez-Breckenridge C, Prabhu S, Rhines L, Zaky W, Lin F, Weinberg JS, Fuller G, Sandberg DI, Johnson JM, McGovern SL. Patterns of failure after radiation therapy in primary spinal high-grade gliomas: A single institutional analysis. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac129. PMID: 36128585; PMCID: PMC9476222.
      Citations:    
    12. Groot J, Ott M, Wei J, Kassab C, Fang D, O'Brien B, Weathers SP, Matsouka CK, Majd NK, Harrison RA, Fuller GN, Huse JT, Long JP, Sawaya R, Rao G, MacDonald TJ, Priebe W, Najem H, DeCuypere M, Heimberger AB. A first-in-human Phase I trial of the oral p-STAT3 inhibitor WP1066 in patients with recurrent malignant glioma. CNS Oncol. 2022 06 01; 11(2):CNS87. PMID: 35575067; PMCID: PMC9134932.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    13. de Groot JF, Kim AH, Prabhu S, Rao G, Laxton AW, Fecci PE, O'Brien BJ, Sloan A, Chiang V, Tatter SB, Mohammadi AM, Placantonakis DG, Strowd RE, Chen C, Hadjipanayis C, Khasraw M, Sun D, Piccioni D, Sinicrope KD, Campian JL, Kurz SC, Williams B, Smith K, Tovar-Spinoza Z, Leuthardt EC. Efficacy of laser interstitial thermal therapy (LITT) for newly diagnosed and recurrent IDH wild-type glioblastoma. Neurooncol Adv. 2022 Jan-Dec; 4(1):vdac040. PMID: 35611270; PMCID: PMC9122789.
      Citations:    
    14. Walker JG, Armstrong TS, O'Brien BJ, Gilbert MR, Casarez RL, Fagundes C, Heijnen CJ, Andersen CR, Yuan Y, Wu J, LoBiondo-Wood G. Associations of meaning of illness with psychosocial, clinical, and immunological characteristics in patients with Leptomeningeal metastasis. Compr Psychoneuroendocrinol. 2021 Nov; 8:100099. PMID: 35757676; PMCID: PMC9216264.
      Citations:    
    15. Harrison RA, Ou A, Naqvi SMAA, Naqvi SM, Weathers SS, O'Brien BJ, de Groot JF, Bruera E. Aggressiveness of care at end of life in patients with high-grade glioma. Cancer Med. 2021 12; 10(23):8387-8394. PMID: 34755486; PMCID: PMC8633215.
      Citations: 2     Fields:    Translation:Humans
    16. Palmisciano P, Haider AS, Nwagwu CD, Wahood W, Yu K, Ene CI, O'Brien BJ, Aoun SG, Cohen-Gadol AA, El Ahmadieh TY. The Role of Immune Checkpoint Inhibitors in Leptomeningeal Disease: A Systematic Review. Anticancer Res. 2021 Nov; 41(11):5333-5342. PMID: 34732403; PMCID: PMC9358987.
      Citations: 1     Fields:    Translation:Humans
    17. Gogia B, Young AL, O'Brien BJ, Okhuysen PC, Kumar VA. Bihemispheric Cortical Infarcts in an Adult Secondary to Escherichia coli K1 Meningitis. Case Rep Neurol. 2021 May-Aug; 13(2):572-577. PMID: 34720964; PMCID: PMC8460961.
      Citations:    
    18. Giridharan N, Glitza Oliva IC, O'Brien BJ, Parker Kerrigan BC, Heimberger AB, Ferguson SD. Targeting the Tumor Microenvironment in Brain Metastasis. Neurosurg Clin N Am. 2020 Oct; 31(4):641-649. PMID: 32921358.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    19. Yust-Katz S, O'Brien B, Vera E, Acquaye A, Armstrong T, Weller M. Burnout and career satisfaction in neuro-oncology: a survey of the Society for Neuro-Oncology and the European Association of Neuro-Oncology memberships. Neuro Oncol. 2020 06 09; 22(6):838-850. PMID: 31832657; PMCID: PMC7283020.
      Citations: 1     Fields:    Translation:Humans
    20. Weathers SP, Penas-Prado M, Pei BL, Ling X, Kassab C, Banerjee P, Bdiwi M, Shaim H, Alsuliman A, Shanley M, de Groot JF, O'Brien BJ, Harrison R, Majd N, Kamiya-Matsuoka C, Fuller GN, Huse JT, Chi L, Rao G, Weinberg JS, Lang FF, Sawaya R, Shpall EJ, Rezvani K, Heimberger AB. Glioblastoma-mediated Immune Dysfunction Limits CMV-specific T Cells and Therapeutic Responses: Results from a Phase I/II Trial. Clin Cancer Res. 2020 07 15; 26(14):3565-3577. PMID: 32299815; PMCID: PMC9347965.
      Citations: 15     Fields:    Translation:HumansCellsCTClinical Trials
    21. de Groot J, Penas-Prado M, Alfaro-Munoz K, Hunter K, Pei BL, O'Brien B, Weathers SP, Loghin M, Kamiya Matsouka C, Yung WKA, Mandel J, Wu J, Yuan Y, Zhou S, Fuller GN, Huse J, Rao G, Weinberg JS, Prabhu SS, McCutcheon IE, Lang FF, Ferguson SD, Sawaya R, Colen R, Yadav SS, Blando J, Vence L, Allison J, Sharma P, Heimberger AB. Window-of-opportunity clinical trial of pembrolizumab in patients with recurrent glioblastoma reveals predominance of immune-suppressive macrophages. Neuro Oncol. 2020 04 15; 22(4):539-549. PMID: 31755915; PMCID: PMC7158647.
      Citations: 41     Fields:    Translation:HumansCells
    22. Hont AB, Cruz CR, Ulrey R, O'Brien B, Stanojevic M, Datar A, Albihani S, Saunders D, Hanajiri R, Panchapakesan K, Darko S, Banerjee P, Fortiz MF, Hoq F, Lang H, Wang Y, Hanley PJ, Dome JS, Bollard CM, Meany HJ. Immunotherapy of Relapsed and Refractory Solid Tumors With Ex Vivo Expanded Multi-Tumor Associated Antigen Specific Cytotoxic T Lymphocytes: A Phase I Study. J Clin Oncol. 2019 09 10; 37(26):2349-2359. PMID: 31356143; PMCID: PMC6804838.
      Citations: 17     Fields:    Translation:HumansCellsCTClinical Trials
    23. Harrison RA, Anderson MD, Cachia D, Kamiya-Matsuoka C, Weathers SS, O'Brien BJ, Penas-Prado M, Yung WKA, Wu J, Yuan Y, de Groot JF. Clinical trial participation of patients with glioblastoma at The University of Texas MD Anderson Cancer Center. Eur J Cancer. 2019 05; 112:83-93. PMID: 30951926.
      Citations: 7     Fields:    Translation:Humans
    24. Ferguson SD, Bindal S, Bassett RL, Haydu LE, McCutcheon IE, Heimberger AB, Li J, O'Brien BJ, Guha-Thakurta N, Tetzlaff MT, Tawbi H, Davies MA, Glitza IC. Predictors of survival in metastatic melanoma patients with leptomeningeal disease (LMD). J Neurooncol. 2019 May; 142(3):499-509. PMID: 30847840.
      Citations: 8     Fields:    Translation:Humans
    25. Cloughesy TF, Mochizuki AY, Orpilla JR, Hugo W, Lee AH, Davidson TB, Wang AC, Ellingson BM, Rytlewski JA, Sanders CM, Kawaguchi ES, Du L, Li G, Yong WH, Gaffey SC, Cohen AL, Mellinghoff IK, Lee EQ, Reardon DA, O'Brien BJ, Butowski NA, Nghiemphu PL, Clarke JL, Arrillaga-Romany IC, Colman H, Kaley TJ, de Groot JF, Liau LM, Wen PY, Prins RM. Neoadjuvant anti-PD-1 immunotherapy promotes a survival benefit with intratumoral and systemic immune responses in recurrent glioblastoma. Nat Med. 2019 03; 25(3):477-486. PMID: 30742122; PMCID: PMC6408961.
      Citations: 381     Fields:    Translation:HumansCells
    26. Maraka S, Groves MD, Mammoser AG, Melguizo-Gavilanes I, Conrad CA, Tremont-Lukats IW, Loghin ME, O'Brien BJ, Puduvalli VK, Sulman EP, Hess KR, Aldape KD, Gilbert MR, de Groot JF, Alfred Yung WK, Penas-Prado M. Phase 1 lead-in to a phase 2 factorial study of temozolomide plus memantine, mefloquine, and metformin as postradiation adjuvant therapy for newly diagnosed glioblastoma. Cancer. 2019 02 01; 125(3):424-433. PMID: 30359477; PMCID: PMC7180384.
      Citations: 19     Fields:    Translation:HumansCTClinical Trials
    27. Ferguson SD, Zheng S, Xiu J, Zhou S, Khasraw M, Brastianos PK, Kesari S, Hu J, Rudnick J, Salacz ME, Piccioni D, Huang S, Davies MA, Glitza IC, Heymach JV, Zhang J, Ibrahim NK, DeGroot JF, McCarty J, O'Brien BJ, Sawaya R, Verhaak RGW, Reddy SK, Priebe W, Gatalica Z, Spetzler D, Heimberger AB. Profiles of brain metastases: Prioritization of therapeutic targets. Int J Cancer. 2018 12 01; 143(11):3019-3026. PMID: 29923182; PMCID: PMC6235694.
      Citations: 15     Fields:    Translation:Humans
    28. Santos-Pinheiro F, Park M, Liu D, Kwong LN, Cruz S, Levine NB, O'Brien BJ, Chen M. Seizure burden pre- and postresection of low-grade gliomas as a predictor of tumor progression in low-grade gliomas. Neurooncol Pract. 2019 May; 6(3):209-217. PMID: 31386048; PMCID: PMC6656314.
      Citations: 4     
    29. Walker J, O'Brien B, Vera E, Armstrong T. Describing Symptom Burden and Functional Status at the Diagnosis of Leptomeningeal Metastasis. Oncol Nurs Forum. 2018 05 01; 45(3):372-379. PMID: 29683126; PMCID: PMC8058624.
      Citations: 1     Fields:    Translation:Humans
    30. Nam JY, O'Brien BJ. Current chemotherapeutic regimens for brain metastases treatment. Clin Exp Metastasis. 2017 10; 34(6-7):391-399. PMID: 28918542.
      Citations: 2     Fields:    Translation:Humans
    31. Hyland A, Ambrose BK, Conway KP, Borek N, Lambert E, Carusi C, Taylor K, Crosse S, Fong GT, Cummings KM, Abrams D, Pierce JP, Sargent J, Messer K, Bansal-Travers M, Niaura R, Vallone D, Hammond D, Hilmi N, Kwan J, Piesse A, Kalton G, Lohr S, Pharris-Ciurej N, Castleman V, Green VR, Tessman G, Kaufman A, Lawrence C, van Bemmel DM, Kimmel HL, Blount B, Yang L, O'Brien B, Tworek C, Alberding D, Hull LC, Cheng YC, Maklan D, Backinger CL, Compton WM. Design and methods of the Population Assessment of Tobacco and Health (PATH) Study. Tob Control. 2017 07; 26(4):371-378. PMID: 27507901; PMCID: PMC5299069.
      Citations: 351     Fields:    Translation:HumansPHPublic Health
    32. Weathers SP, Han X, Liu DD, Conrad CA, Gilbert MR, Loghin ME, O'Brien BJ, Penas-Prado M, Puduvalli VK, Tremont-Lukats I, Colen RR, Yung WKA, de Groot JF. A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma. J Neurooncol. 2016 09; 129(3):487-494. PMID: 27406589; PMCID: PMC5021605.
      Citations: 28     Fields:    Translation:HumansCTClinical Trials
    33. Ladha H, Pawar T, Gilbert MR, Mandel J, O-Brien B, Conrad C, Fields M, Hanna T, Loch C, Armstrong TS. Wound healing complications in brain tumor patients on Bevacizumab. J Neurooncol. 2015 Sep; 124(3):501-6. PMID: 26298437.
      Citations: 5     Fields:    Translation:Humans
    34. Emery SP, Bahtiyar MO, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL. The North American Fetal Therapy Network Consensus Statement: prenatal management of uncomplicated monochorionic gestations. Obstet Gynecol. 2015 May; 125(5):1236-1243. PMID: 25932853.
      Citations: 8     Fields:    Translation:Humans
    35. Bahtiyar MO, Emery SP, Dashe JS, Wilkins-Haug LE, Johnson A, Paek BW, Moon-Grady AJ, Skupski DW, O'Brien BM, Harman CR, Simpson LL, North American Fetal Therapy Network. The North American Fetal Therapy Network consensus statement: prenatal surveillance of uncomplicated monochorionic gestations. Obstet Gynecol. 2015 Jan; 125(1):118-123. PMID: 25560113.
      Citations: 8     Fields:    Translation:HumansPHPublic Health
    36. O'Brien BJ, Colen RR. Post-treatment imaging changes in primary brain tumors. Curr Oncol Rep. 2014; 16(8):397. PMID: 24997979.
      Citations: 13     Fields:    Translation:HumansPHPublic Health
    37. Andriole GL, Crawford ED, Grubb RL, Buys SS, Chia D, Church TR, Fouad MN, Isaacs C, Kvale PA, Reding DJ, Weissfeld JL, Yokochi LA, O'Brien B, Ragard LR, Clapp JD, Rathmell JM, Riley TL, Hsing AW, Izmirlian G, Pinsky PF, Kramer BS, Miller AB, Gohagan JK, Prorok PC, PLCO Project Team. Prostate cancer screening in the randomized Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial: mortality results after 13 years of follow-up. J Natl Cancer Inst. 2012 Jan 18; 104(2):125-32. PMID: 22228146; PMCID: PMC3260132.
      Citations:    
    38. A randomized phase II trial of standard dose bevacizumab versus low dose bevacizumab plus lomustine (CCNU) in adults with recurrent glioblastoma. Journal of Neuro-Oncology. 1-8.
    39. Primary Brain Tumors. 445-456.
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