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FLORIAN MULLER

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Systems Imaging
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sundararaman SA, Miller JJ, Daley EC, O'Brien KA, Kasak P, Daniels AM, Edwards RL, Heidel KM, Bague DA, Wilson MA, Koelper AJ, Kourtoglou EC, White AD, August SA, Apple GA, Rouamba RW, Durand AJ, Esteb JJ, Muller FL, Johnson RJ, Hoops GC, Dowd CS, Odom John AR. Prodrug activation in malaria parasites mediated by an imported erythrocyte esterase, acylpeptide hydrolase (APEH). bioRxiv. 2024 Aug 31. PMID: 39257815; PMCID: PMC11383709.
      Citations:    
    2. Milanes JE, Yan VC, Pham CD, Muller F, Kwain S, Rees KC, Dominy BN, Whitehead DC, Millward SW, Bolejack M, Shek R, Tillery L, Phan IQ, Staker B, Moseman EA, Zhang X, Ma X, Jebet A, Yin X, Morris JC. Enolase inhibitors as therapeutic leads for Naegleria fowleri infection. PLoS Pathog. 2024 Aug; 20(8):e1012412. PMID: 39088549; PMCID: PMC11321563.
      Citations: 1     Fields:    Translation:HumansAnimals
    3. Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. Correction: Cook et al. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses 2022, 14, 2429. Viruses. 2024 Mar 04; 16(3). PMID: 38543851; PMCID: PMC10975337.
      Citations:    Fields:    
    4. Milanes JE, Yan VC, Pham CD, Muller F, Kwain S, Rees KC, Dominy BN, Whitehead DC, Millward SW, Bolejack M, Abendroth J, Phan IQ, Staker B, Moseman EA, Zhang X, Ma X, Jebet A, Yin X, Morris JC. Enolase inhibitors as therapeutic leads for Naegleria fowleri infection. bioRxiv. 2024 Jan 17. PMID: 38293107; PMCID: PMC10827119.
      Citations:    
    5. Roster CP, LaVigne D, Milanes JE, Knight E, Anderson HD, Pizarro S, Harding EM, Morris MT, Yan VC, Pham CD, Muller F, Kwain S, Rees KC, Dominy B, Whitehead DC, Uddin MN, Millward SW, Morris JC. Enolase Inhibitors as Early Lead Therapeutics against Trypanosoma brucei. Pathogens. 2023 Oct 28; 12(11). PMID: 38003754; PMCID: PMC10675445.
      Citations:    
    6. Khadka S, Lin YH, Ackroyd J, Sheng Y, Qian W, Guo S, Chen Y, Behr E, Barekatain Y, Arthur K, Yan V, Hsu WH, Poral A, Tran T, Chaurasia S, Georgiou DK, Asara JM, Millward SW, DePinho RA, Muller FL, Chen YA, Uddin N, Chang Q, Barthel FP. Anaplerotic nutrient stress drives synergy of angiogenesis inhibitors with therapeutics targeting tumor metabolism. bioRxiv. 2023 Oct 19. PMID: 37214825; PMCID: PMC10197573.
      Citations:    
    7. Hicks KG, Cluntun AA, Schubert HL, Hackett SR, Berg JA, Leonard PG, Ajalla Aleixo MA, Zhou Y, Bott AJ, Salvatore SR, Chang F, Blevins A, Barta P, Tilley S, Leifer A, Guzman A, Arok A, Fogarty S, Winter JM, Ahn HC, Allen KN, Block S, Cardoso IA, Ding J, Dreveny I, Gasper WC, Ho Q, Matsuura A, Palladino MJ, Prajapati S, Sun P, Tittmann K, Tolan DR, Unterlass J, VanDemark AP, Vander Heiden MG, Webb BA, Yun CH, Zhao P, Wang B, Schopfer FJ, Hill CP, Nonato MC, Muller FL, Cox JE, Rutter J. Protein-metabolite interactomics of carbohydrate metabolism reveal regulation of lactate dehydrogenase. Science. 2023 03 10; 379(6636):996-1003. PMID: 36893255; PMCID: PMC10262665.
      Citations: 3     Fields:    Translation:HumansCells
    8. Yan VC, Barekatain Y, Lin YH, Satani N, Hammoudi N, Arthur K, Georgiou DK, Jiang Y, Sun Y, Marszalek JR, Millward SW, Muller FL. Comparative Pharmacology of a Bis-Pivaloyloxymethyl Phosphonate Prodrug Inhibitor of Enolase after Oral and Parenteral Administration. ACS Pharmacol Transl Sci. 2023 Feb 10; 6(2):245-252. PMID: 36798479; PMCID: PMC9926520.
      Citations: 1     
    9. Cook S, Wittenburg L, Yan VC, Theil JH, Castillo D, Reagan KL, Williams S, Pham CD, Li C, Muller FL, Murphy BG. An Optimized Bioassay for Screening Combined Anticoronaviral Compounds for Efficacy against Feline Infectious Peritonitis Virus with Pharmacokinetic Analyses of GS-441524, Remdesivir, and Molnupiravir in Cats. Viruses. 2022 11 01; 14(11). PMID: 36366527; PMCID: PMC9697187.
      Citations: 6     Fields:    Translation:AnimalsCells
    10. Yan VC, Pham CD, Ballato ES, Yang KL, Arthur K, Khadka S, Barekatain Y, Shrestha P, Tran T, Poral AH, Washington M, Raghavan S, Czako B, Pisaneschi F, Lin YH, Satani N, Hammoudi N, Ackroyd JJ, Georgiou DK, Millward SW, Muller FL. Prodrugs of a 1-Hydroxy-2-oxopiperidin-3-yl Phosphonate Enolase Inhibitor for the Treatment of ENO1-Deleted Cancers. J Med Chem. 2022 10 27; 65(20):13813-13832. PMID: 36251833; PMCID: PMC9620261.
      Citations: 1     Fields:    Translation:Humans
    11. Khadka S, Vien L, Leonard P, Bover L, Muller F. Generation and Validation of an Anti-Human PANK3 Mouse Monoclonal Antibody. Biomolecules. 2022 09 19; 12(9). PMID: 36139163; PMCID: PMC9496473.
      Citations:    
    12. Barekatain Y, Khadka S, Harris K, Delacerda J, Yan VC, Chen KC, Pham CD, Uddin MN, Avritcher R, Eisenberg EJ, Kalluri R, Millward SW, Muller FL. Quantification of Phosphonate Drugs by 1H-31P HSQC Shows That Rats Are Better Models of Primate Drug Exposure than Mice. Anal Chem. 2022 07 19; 94(28):10045-10053. PMID: 35792073.
      Citations:    Fields:    Translation:Animals
    13. Zamberlan M, Vinelli F, Ek O, Vianello C, Shibata K, Grespi F, Giacomello M, Scorrano L, Boeckx A, Muller F, Coart E, Christian A, Struman I, Herkenne S. Inhibition of the mitochondrial protein Opa1 curtails breast cancer growth. J Exp Clin Cancer Res. 2022 Mar 12; 41(1):95. PMID: 35279198; PMCID: PMC8917763.
      Citations:    Fields:    Translation:HumansAnimalsCells
    14. Park MK, Zhang L, Min KW, Cho JH, Yeh CC, Moon H, Hormaechea-Agulla D, Mun H, Ko S, Lee JW, Jathar S, Smith AS, Yao Y, Giang NT, Vu HH, Yan VC, Bridges MC, Kourtidis A, Muller F, Chang JH, Song SJ, Nakagawa S, Hirose T, Yoon JH, Song MS. NEAT1 is essential for metabolic changes that promote breast cancer growth and metastasis. Cell Metab. 2021 12 07; 33(12):2380-2397.e9. PMID: 34879239; PMCID: PMC8813003.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    15. Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet P, Muller FL, Jez J, Odom John AR. Correction: Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 Nov 25; 10. PMID: 34821554; PMCID: PMC8616559.
      Citations: 1     Fields:    
    16. Yan VC, Muller FL. Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0133321. PMID: 34370586; PMCID: PMC8448088.
      Citations:    Fields:    
    17. Jezewski AJ, Lin YH, Reisz JA, Culp-Hill R, Barekatain Y, Yan VC, D'Alessandro A, Muller FL, Odom John AR. Targeting Host Glycolysis as a Strategy for Antimalarial Development. Front Cell Infect Microbiol. 2021; 11:730413. PMID: 34604112; PMCID: PMC8482815.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Hoops GC, Johnson RJ, Planet PJ, Muller FL, Jez JM, Odom John AR. Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 07 19; 10. PMID: 34279224; PMCID: PMC8318587.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    19. Yan VC, Muller FL. Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola. Antimicrob Agents Chemother. 2021 09 17; 65(10):e0111721. PMID: 34252308; PMCID: PMC8448091.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    20. Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. Nat Commun. 2021 07 09; 12(1):4228. PMID: 34244484; PMCID: PMC8270912.
      Citations: 2     Fields:    Translation:HumansCells
    21. Khadka S, Arthur K, Barekatain Y, Behr E, Washington M, Ackroyd J, Crowley K, Suriyamongkol P, Lin YH, Pham CD, Zielinski R, Trujillo M, Galligan J, Georgiou DK, Asara J, Muller F. Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma. Cancer Metab. 2021 Jun 25; 9(1):27. PMID: 34172075; PMCID: PMC8228515.
      Citations:    
    22. Yan VC, Pham CD, Yan MJ, Yan AJ, Khadka S, Arthur K, Ackroyd JJ, Georgiou DK, Roon LE, Bushman LR, Anderson PL, Li C, Muller FL. Pharmacokinetics of Orally Administered GS-441524 in Dogs. bioRxiv. 2021 May 31. PMID: 34100016; PMCID: PMC8183013.
      Citations:    
    23. Yan VC, Muller FL. Remdesivir for COVID-19: Why Not Dose Higher? Antimicrob Agents Chemother. 2021 03 18; 65(4). PMID: 33558301; PMCID: PMC8097423.
      Citations: 2     Fields:    Translation:HumansCells
    24. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2021 Jan; 3(1):122. PMID: 33340032.
      Citations:    Fields:    
    25. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 12; 2(12):1413-1426. PMID: 33230295; PMCID: PMC7744354.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    26. Yan VC, Muller FL. Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrob Agents Chemother. 2020 11 17; 64(12). PMID: 32988821; PMCID: PMC7674034.
      Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
    27. Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB. ACS Infect Dis. 2020 11 13; 6(11):3064-3075. PMID: 33118347; PMCID: PMC8543975.
      Citations: 2     Fields:    Translation:HumansCells
    28. Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Wang Z, Chen JQ, Maiti SN, Tieu TN, Liu C, Xu C, Haymaker C, Khalili JS, Satani N, Muller F, Cooper LJN, Overwijk WW, Amaria RN, Bernatchez C, Heffernan TP, Peng W, Roszik J, Hwu P, Dominguez AL, Forget MA. Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity. Cancer Immunol Immunother. 2021 Apr; 70(4):1101-1113. PMID: 33123754; PMCID: PMC7979613.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    29. Yan VC, Pham CD, Arthur K, Yang KL, Muller FL. Aliphatic amines are viable pro-drug moieties in phosphonoamidate drugs. Bioorg Med Chem Lett. 2020 12 15; 30(24):127656. PMID: 33130289.
      Citations:    Fields:    
    30. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Rep. 2020 10 20; 33(3):108293. PMID: 33086062; PMCID: PMC7649750.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    31. Barekatain Y, Yan VC, Arthur K, Ackroyd JJ, Khadka S, De Groot J, Huse JT, Muller FL. Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens. Commun Biol. 2020 06 25; 3(1):328. PMID: 32587392; PMCID: PMC7316726.
      Citations:    Translation:HumansAnimalsCells
    32. Yan VC, Muller FL. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Med Chem Lett. 2020 Jul 09; 11(7):1361-1366. PMID: 32665809; PMCID: PMC7315846.
      Citations: 63     
    33. Yan VC, Yang KL, Ballato ES, Khadka S, Shrestha P, Arthur K, Georgiou DK, Washington M, Tran T, Poral AH, Pham CD, Yan MJ, Muller FL. Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study. ACS Med Chem Lett. 2020 Jul 09; 11(7):1484-1489. PMID: 32676158; PMCID: PMC7357215.
      Citations: 1     
    34. Yan VC, Butterfield HE, Poral AH, Yan MJ, Yang KL, Pham CD, Muller FL. Why Great Mitotic Inhibitors Make Poor Cancer Drugs. Trends Cancer. 2020 11; 6(11):924-941. PMID: 32536592; PMCID: PMC7606322.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    35. Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. Cancer Cell. 2020 04 13; 37(4):599-617.e7. PMID: 32243837; PMCID: PMC7178078.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    36. Gammon ST, Pisaneschi F, Bandi ML, Smith MG, Sun Y, Rao Y, Muller F, Wong F, De Groot J, Ackroyd J, Mawlawi O, Davies MA, Gopal YNV, Di Francesco ME, Marszalek JR, Dewhirst M, Piwnica-Worms D. Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo. Cells. 2019 11 21; 8(12). PMID: 31766580; PMCID: PMC6952969.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    37. Mondrag?n L, Mhaidly R, De Donatis GM, Tosolini M, Dao P, Martin AR, Pons C, Chiche J, Jacquin M, Imbert V, Pro?cs E, Boyer L, Doye A, Luciano F, Neels JG, Coutant F, Fabien N, Sormani L, Rubio-Pati?o C, Bossowski JP, Muller F, Marchetti S, Villa E, Peyron JF, Gaulard P, Lemonnier F, Asnafi V, Genestier L, Benhida R, Fourni? JJ, Passeron T, Ricci JE, Verhoeyen E. GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-?B-Dependent Mechanism. Cancer Cell. 2019 09 16; 36(3):268-287.e10. PMID: 31447347.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    38. Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL. The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues. Molecules. 2019 Jul 09; 24(13). PMID: 31324042; PMCID: PMC6651268.
      Citations: 1     Fields:    Translation:Cells
    39. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5. PMID: 30625329.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    40. Deribe YL, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 Oct; 24(10):1627. PMID: 30104769.
      Citations: 5     Fields:    
    41. McKenzie JA, Mbofung RM, Malu S, Zhang M, Ashkin E, Devi S, Williams L, Tieu T, Peng W, Pradeep S, Xu C, Zorro Manrique S, Liu C, Huang L, Chen Y, Forget MA, Haymaker C, Bernatchez C, Satani N, Muller F, Roszik J, Kalra A, Heffernan T, Sood A, Hu J, Amaria R, Davis RE, Hwu P. The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy. J Natl Cancer Inst. 2018 07 01; 110(7):777-786. PMID: 29267866; PMCID: PMC6037061.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    42. Lissanu Deribe Y, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 07; 24(7):1047-1057. PMID: 29892061; PMCID: PMC6650267.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    43. Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046. PMID: 29892070.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    44. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Gabriel Sauv? CE. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 01 08; 33(1):152. PMID: 29316430; PMCID: PMC5892424.
      Citations: 78     Fields:    
    45. Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J. FOXO protects against age-progressive axonal degeneration. Aging Cell. 2018 02; 17(1). PMID: 29178390; PMCID: PMC5771393.
      Citations: 19     Fields:    Translation:AnimalsCells
    46. Mbofung RM, McKenzie JA, Malu S, Zhang M, Peng W, Liu C, Kuiatse I, Tieu T, Williams L, Devi S, Ashkin E, Xu C, Huang L, Zhang M, Talukder AH, Tripathi SC, Khong H, Satani N, Muller FL, Roszik J, Heffernan T, Allison JP, Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P. HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes. Nat Commun. 2017 09 06; 8(1):451. PMID: 28878208; PMCID: PMC5587668.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    47. Wang Q, Hu B, Hu X, Kim H, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW, Squatrito M, Sauv? CG. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 07 10; 32(1):42-56.e6. PMID: 28697342; PMCID: PMC5599156.
      Citations: 549     Fields:    Translation:HumansCells
    48. Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L, Sgambato A. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366. PMID: 28178232; PMCID: PMC7609022.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    49. Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 02 02; 542(7639):119-123. PMID: 28099419; PMCID: PMC5398413.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    50. Satani N, Lin YH, Hammoudi N, Raghavan S, Georgiou DK, Muller FL. ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase. PLoS One. 2016; 11(12):e0168739. PMID: 28030597; PMCID: PMC5193436.
      Citations: 12     Fields:    Translation:HumansCells
    51. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec; 12(12):1053-1058. PMID: 27723749; PMCID: PMC5110371.
      Citations: 37     Fields:    Translation:HumansCells
    52. Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends Cancer. 2015 Nov 01; 1(3):161-173. PMID: 26870836; PMCID: PMC4746004.
      Citations: 50     Fields:    
    53. Sobolewski C, Rhim J, Legrand N, Muller F, Cerella C, Mack F, Chateauvieux S, Kim JG, Yoon AY, Kim KW, Dicato M, Diederich M. 2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells. J Pharmacol Exp Ther. 2015 Nov; 355(2):308-28. PMID: 26330537.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    54. Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2015 Sep 10; 525(7568):278. PMID: 26153864.
      Citations:    Fields:    
    55. Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 2015 Mar; 25(3):316-27. PMID: 25650244; PMCID: PMC4352879.
      Citations: 174     Fields:    Translation:HumansCells
    56. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF, S?nchez N. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct 30; 514(7524):628-32. PMID: 25119024; PMCID: PMC4376130.
      Citations: 549     Fields:    Translation:AnimalsCells
    57. Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med. 2012 Oct; 18(10):1503-10. PMID: 22983396; PMCID: PMC3777533.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    58. Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ, Schwarzl?nder M, M?ller FL. Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol. 2012 Oct; 22(10):503-8. PMID: 22917552.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    59. Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16; 488(7411):337-42. PMID: 22895339; PMCID: PMC3712624.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    60. Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct; 11(5):770-82. PMID: 22672615; PMCID: PMC3444532.
      Citations: 50     Fields:    Translation:AnimalsCells
    61. Lustgarten MS, Bhattacharya A, Muller FL, Jang YC, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):515-21. PMID: 22613204; PMCID: PMC3400138.
      Citations: 39     Fields:    Translation:AnimalsCells
    62. Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, Richardson A, Van Remmen H. Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiol Aging. 2012 Aug; 33(8):1829-32. PMID: 21763036.
      Citations: 28     Fields:    Translation:HumansAnimals
    63. Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 2011 Jun; 10(3):493-505. PMID: 21385310; PMCID: PMC3094473.
      Citations: 44     Fields:    Translation:AnimalsCells
    64. Colla S, Liesa M, Moslehi J, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA, Sahin E, M?ller FL. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. PMID: 21307849; PMCID: PMC3741661.
      Citations: 555     Fields:    Translation:AnimalsCells
    65. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Horner JW, Maratos-Flier E, Depinho RA, Cadi?anos J. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 06; 469(7328):102-6. PMID: 21113150; PMCID: PMC3057569.
      Citations: 309     Fields:    Translation:AnimalsCells
    66. Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J. 2010 May; 24(5):1376-90. PMID: 20040516; PMCID: PMC2987499.
      Citations: 153     Fields:    Translation:AnimalsCells
    67. Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):540-53. PMID: 19896444; PMCID: PMC3285492.
      Citations: 222     Fields:    Translation:AnimalsCells
    68. Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol Cell Physiol. 2009 Dec; 297(6):C1520-32. PMID: 19776389; PMCID: PMC2793066.
      Citations: 43     Fields:    Translation:AnimalsCells
    69. Bhattacharya A, Muller FL, Liu Y, Sabia M, Liang H, Song W, Jang YC, Ran Q, Van Remmen H. Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. J Biol Chem. 2009 Jan 02; 284(1):46-55. PMID: 19001413; PMCID: PMC2610521.
      Citations: 39     Fields:    Translation:AnimalsCells
    70. Muller FL, Liu Y, Jernigan A, Borchelt D, Richardson A, Van Remmen H. MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models. Muscle Nerve. 2008 Sep; 38(3):1173-83. PMID: 18720509.
      Citations: 16     Fields:    Translation:Animals
    71. Pierce A, Mirzaei H, Muller F, De Waal E, Taylor AB, Leonard S, Van Remmen H, Regnier F, Richardson A, Chaudhuri A. GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis. J Mol Biol. 2008 Oct 24; 382(5):1195-210. PMID: 18706911; PMCID: PMC6348903.
      Citations: 29     Fields:    Translation:AnimalsCells
    72. Muller FL, Liu Y, Abdul-Ghani MA, Lustgarten MS, Bhattacharya A, Jang YC, Van Remmen H. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J. 2008 Jan 15; 409(2):491-9. PMID: 17916065.
      Citations: 65     Fields:    Translation:AnimalsCells
    73. Muller FL, Song W, Jang YC, Liu Y, Sabia M, Richardson A, Van Remmen H. Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1159-68. PMID: 17584954.
      Citations: 166     Fields:    Translation:AnimalsCells
    74. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med. 2007 Aug 15; 43(4):477-503. PMID: 17640558.
      Citations: 348     Fields:    Translation:HumansAnimalsCells
    75. Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med. 2006 Jun 01; 40(11):1993-2004. PMID: 16716900.
      Citations: 197     Fields:    
    76. Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, Van Remmen H. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev. 2006 Mar; 127(3):298-306. PMID: 16405961.
      Citations: 85     Fields:    Translation:AnimalsCells
    77. Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem. 2004 Nov 19; 279(47):49064-73. PMID: 15317809.
      Citations: 384     Fields:    Translation:AnimalsCells
    78. Muller FL, Roberts AG, Bowman MK, Kramer DM. Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production. Biochemistry. 2003 Jun 03; 42(21):6493-9. PMID: 12767232.
      Citations: 40     Fields:    Translation:AnimalsCells
    79. Lia-Baldini AS, Muller F, Taillandier A, Gibrat JF, Mouchard M, Robin B, Simon-Bouy B, Serre JL, Aylsworth AS, Bieth E, Delanote S, Freisinger P, Hu JC, Krohn HP, Nunes ME, Mornet E. A molecular approach to dominance in hypophosphatasia. Hum Genet. 2001 Jul; 109(1):99-108. PMID: 11479741.
      Citations: 34     Fields:    Translation:HumansCells
    80. Rowland FS, Blake DR, Larsen BR, Lindskog A, Peterson PJ, Williams WP, Wallington TJ, Pilling MJ, Carslaw N, Creasey DJ, Heard DE, Jacobs P, Lee J, Lewis AC, McQuaid JB, Stockwell WR, Frank H, Sacco P, Cocheo V, Lynge E, Andersen A, Nilsson R, Barlow L, Pukkala E, Nordlinder R, Boffetta P, Grandjean P, Heikkil P, Hürte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T, Borowiak A, De Saeger E, Schnitzler KG, Gravenhorst G, Jacobi HW, Moelders S, Lammel G, Busch G, Beese FO, Dentener FJ, Feichter J, Fraedrich K, Roelofs GJ, Friedrich R, Reis S, Voehringer F, Simpson D, Moussiopoulos N, Sahm P, Tourlou PM, Salmons R, Papameletiou D, Maqueda JM, Suhr PB, Bell W, Paton-Walsh C, Woods PT, Partridge RH, Slemr J, Slemr F, Schmidbauer N, Ravishankara AR, Jenkin ME, de Leeuw G, van Eijk AM, Flossmann AI, Wobrock W, Mestayer PG, Tranchant B, Ljungström E, Karlsson R, Larsen SE, Roemer M, Builtjes PJ, Koffi B, Koffi EN, Ro-Poulsen H, Mikkelsen TN, Hummelshøj P, Hovmand MF, Simoneit BR, van der Meulen A, Meyer MB, Berndt T, Böge O, Stratmann F, Cass GR, Harrison RM, Shi JP, Hoffmann T, Warscheid B, Bandur R, Marggraf U, Nigge W, Kamens R, Jang M, Strommen M, Chien CJ, Leach K, Ammann M, Kalberer M, Arens F, Lavanchy V, Gâggeler HW, Baltensperger U, Davies JA, Cox RA, Alonso SG, Pastor RP, Argüello GA, Willner H, Bogillo VI, Pokrovskiy VA, Kuraev OV, Gozhyk PF, Bolzacchini E, Bruschi M, Fantucci P, Meinardi S, Orlandi M, Rindone B, Bohn B, Zetzsch C, Brussol C, Duane M, Larsen B, Carlier P, Kotzias D, Caracena AB, Aznar AM, Ferradás EG, Christensen CS, Skov H, Jensen NO, Lohse C, Chatzis C, Boaretto C, Quaglio F, Zaratin L, Pagani D, Cocheo L, Asnar AM, Baldan A, Ballesta PP, Ferradas EG, Gonzalez-Flesca N, Goelen E, Hansen AB, Consonni V, Gramatica P, Santagostino A, Galvani P, Todeschini R, Dippel G, Reinhardt H, Zellner R, Dämmer K, Bednarek G, Breil M, Febo A, Allegrini I, Giliberti C, Perrino C, Fogg PG, Geiger H, Barnes I, Becker KH, Maurer T, Geyskens F, Bormans R, Lambrechts M, Giese M, Glasius M, Hornung P, Jacobsen JK, Klausen HS, Klitgaard KC, Møller CK, Petersen AP, Petersen LS, Wessel S, Hansen TS, Boaretto E, Heinemeier J, Di Bella D, Lahaniati M, Calogirou A, Jensen NR, Hjorth J, Cicolella A, Bates M, Bastin E, Gurbanov MA, Akhmedly KM, Balayev VS, Haselmann KF, Ketola R, Laturnus F, Lauritsen FR, Grøn C, Herrmann H, Ervens B, Reese A, Umschlag T, Wicktor F, Müller K, Hayman GD, Courtney M, Johnson MS, Hegelund F, Nelander B, Kirchner F, Klotz B, Sørensen S, Etzkorn T, Platt U, Wirtz K, Martín-Reviejo M, Martinez E, Cabañas B, Aranda A, Martín P, Salgado S, Rodriguez D, Masclet P, Jaffrezo JL, Hillamo R, Mellouki A, Le Calvé S, Le Bras G, Moriarty J, O'Donnell S, Wenger J, Sidebottom H, Mingarrol MT, Cosin S, Sanz MJ, Bravo I, Gonzalez D, Pérez MA, Mustafaev I, Mammadova S, Noda J, Hallquist M, Langer S, Nohara K, Kutsuna S, Ibusuki T, Oehme M, Kölliker S, Brombacher S, Merz L, Cabezas AQ, Peeters J, Vereecken L, El Yazal J, Pfeffer HU, Breuer L, Platz J, Nielsen OJ, Sehested J, Ball JC, Hurley MD, Straccia AM, Schneider WF, Pérez-Casany MP, Nebot-Gil I, Sánchez-Marín J, Putz E, Folberth G, Pfister G, Weissflog L, Elansky NP, Shao M, Heiden AC, Kley D, Rockel P, Wildt J, Silva GV, Vasconcelos MT, Fernandes EO, Santos AM, Hansen A, Løfstrøm P, Lorenzen G, Stabel JR, Wolkoff P, Pedersen T, Strom AB, Hertel O, Jensen FP, Galle B, Wallin S, Theloke J, Libuda HG, Zabel F, Touaty M, Bonsang B, Ullerstam M, Bonard A, Manning M, Nolan S, O'Sullivan N, Collins E, Chadwick P, O'Leary B, Treacy J, Clausen PA, Wilkins CK, Hougaard KS, Nielsen GD, Zilinskis V, Jansons G, Peksens A, Lazdins A, Arinci YV, Erdöl N, Ekinci E, Okutan H, Manlafalioglu I, Bakeas EB, Siskos PA, Viras LG, Smirnioudi VN, Bottenheim JW, Biesenthal T, Gong W, Makar P, Delmas V, Menard T, Tatry V, Moussafir J, Thomas D, Coppalle A, Ellermann T, Frohn L, Manscher OH, Friis J, Girgzdiene R, Girgzdys A, Gurevich NA, Gårdfeldt K, Hermans C, Vandaele AC, et al. Abstracts of the 6th FECS Conference 1998 Lectures. Environ Sci Pollut Res Int. 1998; 5(3):119-96. PMID: 19002640.
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    85. Collateral Lethality. Trends in Cancer. 1:161-173.
    86. SF2312 is a natural phosphonate inhibitor of enolase. Nature Chemical Biology.
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    88. Functional regulation of FoxO1 in neural stem cell differentiation. Cell Death and Differentiation. 22:2034-2045.
    89. Erratum. Nature Medicine. 18:1857.
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