TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Systems Imaging
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Yan VC, Muller FL. Single-Cell RNA Sequencing Supports Preferential Bioactivation of Remdesivir in the Liver. Antimicrob Agents Chemother. 2021 Aug 09; AAC0133321. PMID: 34370586.
      Citations:    Fields:    
    2. Miller JJ, Shah IT, Hatten J, Barekatain Y, Mueller EA, Moustafa AM, Edwards RL, Dowd CS, Planet PJ, Muller FL, Jez JM, Odom John AR. Structure-guided microbial targeting of antistaphylococcal prodrugs. Elife. 2021 07 19; 10. PMID: 34279224.
      Citations:    Fields:    
    3. Yan VC, Muller FL. Why Remdesivir Failed: Preclinical Assumptions Overestimate the Clinical Efficacy of Remdesivir for COVID-19 and Ebola. Antimicrob Agents Chemother. 2021 Jul 12; AAC0111721. PMID: 34252308.
      Citations:    Fields:    
    4. Barekatain Y, Ackroyd JJ, Yan VC, Khadka S, Wang L, Chen KC, Poral AH, Tran T, Georgiou DK, Arthur K, Lin YH, Satani N, Ballato ES, Behr EI, deCarvalho AC, Verhaak RGW, de Groot J, Huse JT, Asara JM, Kalluri R, Muller FL. Homozygous MTAP deletion in primary human glioblastoma is not associated with elevation of methylthioadenosine. Nat Commun. 2021 07 09; 12(1):4228. PMID: 34244484.
      Citations:    Fields:    Translation:HumansCells
    5. Khadka S, Arthur K, Barekatain Y, Behr E, Washington M, Ackroyd J, Crowley K, Suriyamongkol P, Lin YH, Pham CD, Zielinski R, Trujillo M, Galligan J, Georgiou DK, Asara J, Muller F. Impaired anaplerosis is a major contributor to glycolysis inhibitor toxicity in glioma. Cancer Metab. 2021 Jun 25; 9(1):27. PMID: 34172075.
    6. Yan VC, Pham CD, Yan MJ, Yan AJ, Khadka S, Arthur K, Ackroyd JJ, Georgiou DK, Roon LE, Bushman LR, Anderson PL, Li C, Muller FL. Pharmacokinetics of Orally Administered GS-441524 in Dogs. bioRxiv. 2021 May 31. PMID: 34100016.
    7. Yan VC, Muller FL. Remdesivir for COVID-19: Why Not Dose Higher? Antimicrob Agents Chemother. 2021 03 18; 65(4). PMID: 33558301.
      Citations:    Fields:    Translation:Humans
    8. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. Author Correction: An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2021 Jan; 3(1):122. PMID: 33340032.
    9. Lin YH, Satani N, Hammoudi N, Yan VC, Barekatain Y, Khadka S, Ackroyd JJ, Georgiou DK, Pham CD, Arthur K, Maxwell D, Peng Z, Leonard PG, Czako B, Pisaneschi F, Mandal P, Sun Y, Zielinski R, Pando SC, Wang X, Tran T, Xu Q, Wu Q, Jiang Y, Kang Z, Asara JM, Priebe W, Bornmann W, Marszalek JR, DePinho RA, Muller FL. An enolase inhibitor for the targeted treatment of ENO1-deleted cancers. Nat Metab. 2020 12; 2(12):1413-1426. PMID: 33230295.
      Citations: 5     Translation:HumansAnimalsCells
    10. Yan VC, Muller FL. Captisol and GS-704277, but Not GS-441524, Are Credible Mediators of Remdesivir's Nephrotoxicity. Antimicrob Agents Chemother. 2020 11 17; 64(12). PMID: 32988821.
      Citations: 5     Fields:    Translation:HumansPHPublic Health
    11. Mikati MO, Miller JJ, Osbourn DM, Barekatain Y, Ghebremichael N, Shah IT, Burnham CD, Heidel KM, Yan VC, Muller FL, Dowd CS, Edwards RL, Odom John AR. Antimicrobial Prodrug Activation by the Staphylococcal Glyoxalase GloB. ACS Infect Dis. 2020 11 13; 6(11):3064-3075. PMID: 33118347.
      Citations: 1     Fields:    Translation:HumansCells
    12. Punt S, Malu S, McKenzie JA, Manrique SZ, Doorduijn EM, Mbofung RM, Williams L, Silverman DA, Ashkin EL, Dominguez AL, Wang Z, Chen JQ, Maiti SN, Tieu TN, Liu C, Xu C, Forget MA, Haymaker C, Khalili JS, Satani N, Muller F, Cooper LJN, Overwijk WW, Amaria RN, Bernatchez C, Heffernan TP, Peng W, Roszik J, Hwu P. Aurora kinase inhibition sensitizes melanoma cells to T-cell-mediated cytotoxicity. Cancer Immunol Immunother. 2021 Apr; 70(4):1101-1113. PMID: 33123754.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    13. Yan VC, Pham CD, Arthur K, Yang KL, Muller FL. Aliphatic amines are viable pro-drug moieties in phosphonoamidate drugs. Bioorg Med Chem Lett. 2020 12 15; 30(24):127656. PMID: 33130289.
      Citations:    Fields:    
    14. Maitituoheti M, Keung EZ, Tang M, Yan L, Alam H, Han G, Singh AK, Raman AT, Terranova C, Sarkar S, Orouji E, Amin SB, Sharma S, Williams M, Samant NS, Dhamdhere M, Zheng N, Shah T, Shah A, Axelrad JB, Anvar NE, Lin YH, Jiang S, Chang EQ, Ingram DR, Wang WL, Lazar A, Lee MG, Muller F, Wang L, Ying H, Rai K. Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma. Cell Rep. 2020 10 20; 33(3):108293. PMID: 33086062.
      Citations: 3     Fields:    
    15. Barekatain Y, Yan VC, Arthur K, Ackroyd JJ, Khadka S, De Groot J, Huse JT, Muller FL. Robust detection of oncometabolic aberrations by 1H-13C heteronuclear single quantum correlation in intact biological specimens. Commun Biol. 2020 06 25; 3(1):328. PMID: 32587392.
      Citations:    Translation:HumansAnimalsCells
    16. Yan VC, Muller FL. Advantages of the Parent Nucleoside GS-441524 over Remdesivir for Covid-19 Treatment. ACS Med Chem Lett. 2020 Jul 09; 11(7):1361-1366. PMID: 32665809.
      Citations: 29     
    17. Yan VC, Yang KL, Ballato ES, Khadka S, Shrestha P, Arthur K, Georgiou DK, Washington M, Tran T, Poral AH, Pham CD, Yan MJ, Muller FL. Bioreducible Phosphonoamidate Pro-drug Inhibitor of Enolase: Proof of Concept Study. ACS Med Chem Lett. 2020 Jul 09; 11(7):1484-1489. PMID: 32676158.
      Citations: 1     
    18. Yan VC, Butterfield HE, Poral AH, Yan MJ, Yang KL, Pham CD, Muller FL. Why Great Mitotic Inhibitors Make Poor Cancer Drugs. Trends Cancer. 2020 11; 6(11):924-941. PMID: 32536592.
      Citations: 4     Fields:    
    19. Jang YC, Rodriguez K, Lustgarten MS, Muller FL, Bhattacharya A, Pierce A, Choi JJ, Lee NH, Chaudhuri A, Richardson AG, Van Remmen H. Superoxide-mediated oxidative stress accelerates skeletal muscle atrophy by synchronous activation of proteolytic systems. Geroscience. 2020 12; 42(6):1579-1591. PMID: 32451848.
      Citations: 3     Fields:    Translation:AnimalsCells
    20. Alam H, Tang M, Maitituoheti M, Dhar SS, Kumar M, Han CY, Ambati CR, Amin SB, Gu B, Chen TY, Lin YH, Chen J, Muller FL, Putluri N, Flores ER, DeMayo FJ, Baseler L, Rai K, Lee MG. KMT2D Deficiency Impairs Super-Enhancers to Confer a Glycolytic Vulnerability in Lung Cancer. Cancer Cell. 2020 04 13; 37(4):599-617.e7. PMID: 32243837.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    21. Gammon ST, Pisaneschi F, Bandi ML, Smith MG, Sun Y, Rao Y, Muller F, Wong F, De Groot J, Ackroyd J, Mawlawi O, Davies MA, Gopal YNV, Di Francesco ME, Marszalek JR, Dewhirst M, Piwnica-Worms D. Mechanism-Specific Pharmacodynamics of a Novel Complex-I Inhibitor Quantified by Imaging Reversal of Consumptive Hypoxia with [18F]FAZA PET In Vivo. Cells. 2019 11 21; 8(12). PMID: 31766580.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    22. Mondragón L, Mhaidly R, De Donatis GM, Tosolini M, Dao P, Martin AR, Pons C, Chiche J, Jacquin M, Imbert V, Proïcs E, Boyer L, Doye A, Luciano F, Neels JG, Coutant F, Fabien N, Sormani L, Rubio-Patiño C, Bossowski JP, Muller F, Marchetti S, Villa E, Peyron JF, Gaulard P, Lemonnier F, Asnafi V, Genestier L, Benhida R, Fournié JJ, Passeron T, Ricci JE, Verhoeyen E. GAPDH Overexpression in the T Cell Lineage Promotes Angioimmunoblastic T Cell Lymphoma through an NF-?B-Dependent Mechanism. Cancer Cell. 2019 09 16; 36(3):268-287.e10. PMID: 31447347.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    23. Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL. The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues. Molecules. 2019 Jul 09; 24(13). PMID: 31324042.
      Citations: 1     Fields:    Translation:Cells
    24. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5. PMID: 30625329.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    25. Deribe YL, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Author Correction: Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 Oct; 24(10):1627. PMID: 30104769.
      Citations: 4     Fields:    
    26. McKenzie JA, Mbofung RM, Malu S, Zhang M, Ashkin E, Devi S, Williams L, Tieu T, Peng W, Pradeep S, Xu C, Zorro Manrique S, Liu C, Huang L, Chen Y, Forget MA, Haymaker C, Bernatchez C, Satani N, Muller F, Roszik J, Kalra A, Heffernan T, Sood A, Hu J, Amaria R, Davis RE, Hwu P. The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy. J Natl Cancer Inst. 2018 07 01; 110(7):777-786. PMID: 29267866.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    27. Lissanu Deribe Y, Sun Y, Terranova C, Khan F, Martinez-Ledesma J, Gay J, Gao G, Mullinax RA, Khor T, Feng N, Lin YH, Wu CC, Reyes C, Peng Q, Robinson F, Inoue A, Kochat V, Liu CG, Asara JM, Moran C, Muller F, Wang J, Fang B, Papadimitrakopoulou V, Wistuba II, Rai K, Marszalek J, Futreal PA. Mutations in the SWI/SNF complex induce a targetable dependence on oxidative phosphorylation in lung cancer. Nat Med. 2018 07; 24(7):1047-1057. PMID: 29892061.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    28. Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046. PMID: 29892070.
      Citations: 159     Fields:    Translation:HumansAnimalsCells
    29. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Gabriel Sauvé CE, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2018 01 08; 33(1):152. PMID: 29316430.
      Citations: 50     Fields:    
    30. Hwang I, Oh H, Santo E, Kim DY, Chen JW, Bronson RT, Locasale JW, Na Y, Lee J, Reed S, Toth M, Yu WH, Muller FL, Paik J. FOXO protects against age-progressive axonal degeneration. Aging Cell. 2018 02; 17(1). PMID: 29178390.
      Citations: 16     Fields:    Translation:AnimalsCells
    31. Mbofung RM, McKenzie JA, Malu S, Zhang M, Peng W, Liu C, Kuiatse I, Tieu T, Williams L, Devi S, Ashkin E, Xu C, Huang L, Zhang M, Talukder AH, Tripathi SC, Khong H, Satani N, Muller FL, Roszik J, Heffernan T, Allison JP, Lizee G, Hanash SM, Proia D, Amaria R, Davis RE, Hwu P. HSP90 inhibition enhances cancer immunotherapy by upregulating interferon response genes. Nat Commun. 2017 09 06; 8(1):451. PMID: 28878208.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    32. Wang Q, Hu B, Hu X, Kim H, Squatrito M, Scarpace L, deCarvalho AC, Lyu S, Li P, Li Y, Barthel F, Cho HJ, Lin YH, Satani N, Martinez-Ledesma E, Zheng S, Chang E, Sauvé CG, Olar A, Lan ZD, Finocchiaro G, Phillips JJ, Berger MS, Gabrusiewicz KR, Wang G, Eskilsson E, Hu J, Mikkelsen T, DePinho RA, Muller F, Heimberger AB, Sulman EP, Nam DH, Verhaak RGW. Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment. Cancer Cell. 2017 07 10; 32(1):42-56.e6. PMID: 28697342.
      Citations: 356     Fields:    Translation:HumansCells
    33. Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366. PMID: 28178232.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    34. Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 02 02; 542(7639):119-123. PMID: 28099419.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    35. Satani N, Lin YH, Hammoudi N, Raghavan S, Georgiou DK, Muller FL. ENOblock Does Not Inhibit the Activity of the Glycolytic Enzyme Enolase. PLoS One. 2016; 11(12):e0168739. PMID: 28030597.
      Citations: 8     Fields:    Translation:HumansCells
    36. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec; 12(12):1053-1058. PMID: 27723749.
      Citations: 25     Fields:    Translation:HumansCells
    37. Muller FL, Aquilanti EA, DePinho RA. Collateral Lethality: A new therapeutic strategy in oncology. Trends Cancer. 2015 Nov 01; 1(3):161-173. PMID: 26870836.
      Citations: 39     Fields:    
    38. Kim DY, Hwang I, Muller FL, Paik JH. Functional regulation of FoxO1 in neural stem cell differentiation. Cell Death Differ. 2015 Dec; 22(12):2034-45. PMID: 26470727.
      Citations: 25     Fields:    Translation:AnimalsCells
    39. Sobolewski C, Rhim J, Legrand N, Muller F, Cerella C, Mack F, Chateauvieux S, Kim JG, Yoon AY, Kim KW, Dicato M, Diederich M. 2,5-Dimethyl-celecoxib inhibits cell cycle progression and induces apoptosis in human leukemia cells. J Pharmacol Exp Ther. 2015 Nov; 355(2):308-28. PMID: 26330537.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    40. Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2015 Sep 10; 525(7568):278. PMID: 26153864.
      Citations:    Fields:    
    41. Kim H, Zheng S, Amini SS, Virk SM, Mikkelsen T, Brat DJ, Grimsby J, Sougnez C, Muller F, Hu J, Sloan AE, Cohen ML, Van Meir EG, Scarpace L, Laird PW, Weinstein JN, Lander ES, Gabriel S, Getz G, Meyerson M, Chin L, Barnholtz-Sloan JS, Verhaak RG. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res. 2015 Mar; 25(3):316-27. PMID: 25650244.
      Citations: 140     Fields:    Translation:HumansCells
    42. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct 30; 514(7524):628-32. PMID: 25119024.
      Citations: 450     Fields:    Translation:AnimalsCells
    43. Sobolewski C, Muller F, Cerella C, Dicato M, Diederich M. Celecoxib prevents curcumin-induced apoptosis in a hematopoietic cancer cell model. Mol Carcinog. 2015 Oct; 54(10):999-1013. PMID: 24798089.
      Citations: 4     Fields:    Translation:HumansCells
    44. Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L. Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma. Nat Med. 2012 Oct; 18(10):1503-10. PMID: 22983396.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    45. Schwarzländer M, Murphy MP, Duchen MR, Logan DC, Fricker MD, Halestrap AP, Müller FL, Rizzuto R, Dick TP, Meyer AJ, Sweetlove LJ. Mitochondrial 'flashes': a radical concept repHined. Trends Cell Biol. 2012 Oct; 22(10):503-8. PMID: 22917552.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    46. Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RA. Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16; 488(7411):337-42. PMID: 22895339.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    47. Jang YC, Liu Y, Hayworth CR, Bhattacharya A, Lustgarten MS, Muller FL, Chaudhuri A, Qi W, Li Y, Huang JY, Verdin E, Richardson A, Van Remmen H. Dietary restriction attenuates age-associated muscle atrophy by lowering oxidative stress in mice even in complete absence of CuZnSOD. Aging Cell. 2012 Oct; 11(5):770-82. PMID: 22672615.
      Citations: 38     Fields:    Translation:AnimalsCells
    48. Lustgarten MS, Bhattacharya A, Muller FL, Jang YC, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. Complex I generated, mitochondrial matrix-directed superoxide is released from the mitochondria through voltage dependent anion channels. Biochem Biophys Res Commun. 2012 Jun 08; 422(3):515-21. PMID: 22613204.
      Citations: 31     Fields:    Translation:AnimalsCells
    49. Bhattacharya A, Bokov A, Muller FL, Jernigan AL, Maslin K, Diaz V, Richardson A, Van Remmen H. Dietary restriction but not rapamycin extends disease onset and survival of the H46R/H48Q mouse model of ALS. Neurobiol Aging. 2012 Aug; 33(8):1829-32. PMID: 21763036.
      Citations: 22     Fields:    Translation:HumansAnimals
    50. Lustgarten MS, Jang YC, Liu Y, Qi W, Qin Y, Dahia PL, Shi Y, Bhattacharya A, Muller FL, Shimizu T, Shirasawa T, Richardson A, Van Remmen H. MnSOD deficiency results in elevated oxidative stress and decreased mitochondrial function but does not lead to muscle atrophy during aging. Aging Cell. 2011 Jun; 10(3):493-505. PMID: 21385310.
      Citations: 42     Fields:    Translation:AnimalsCells
    51. Sahin E, Colla S, Liesa M, Moslehi J, Müller FL, Guo M, Cooper M, Kotton D, Fabian AJ, Walkey C, Maser RS, Tonon G, Foerster F, Xiong R, Wang YA, Shukla SA, Jaskelioff M, Martin ES, Heffernan TP, Protopopov A, Ivanova E, Mahoney JE, Kost-Alimova M, Perry SR, Bronson R, Liao R, Mulligan R, Shirihai OS, Chin L, DePinho RA. Telomere dysfunction induces metabolic and mitochondrial compromise. Nature. 2011 Feb 17; 470(7334):359-65. PMID: 21307849.
      Citations: 478     Fields:    Translation:AnimalsCells
    52. Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadiñanos J, Horner JW, Maratos-Flier E, Depinho RA. Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 06; 469(7328):102-6. PMID: 21113150.
      Citations: 270     Fields:    Translation:AnimalsCells
    53. Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H. Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration. FASEB J. 2010 May; 24(5):1376-90. PMID: 20040516.
      Citations: 131     Fields:    Translation:AnimalsCells
    54. Paik JH, Ding Z, Narurkar R, Ramkissoon S, Muller F, Kamoun WS, Chae SS, Zheng H, Ying H, Mahoney J, Hiller D, Jiang S, Protopopov A, Wong WH, Chin L, Ligon KL, DePinho RA. FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell. 2009 Nov 06; 5(5):540-53. PMID: 19896444.
      Citations: 197     Fields:    Translation:AnimalsCells
    55. Lustgarten MS, Jang YC, Liu Y, Muller FL, Qi W, Steinhelper M, Brooks SV, Larkin L, Shimizu T, Shirasawa T, McManus LM, Bhattacharya A, Richardson A, Van Remmen H. Conditional knockout of Mn-SOD targeted to type IIB skeletal muscle fibers increases oxidative stress and is sufficient to alter aerobic exercise capacity. Am J Physiol, Cell Physiol. 2009 Dec; 297(6):C1520-32. PMID: 19776389.
      Citations: 40     Translation:AnimalsCells
    56. Muller FL. A critical evaluation of cpYFP as a probe for superoxide. Free Radic Biol Med. 2009 Dec 15; 47(12):1779-80. PMID: 19778603.
      Citations: 18     Fields:    Translation:Animals
    57. Bhattacharya A, Muller FL, Liu Y, Sabia M, Liang H, Song W, Jang YC, Ran Q, Van Remmen H. Denervation induces cytosolic phospholipase A2-mediated fatty acid hydroperoxide generation by muscle mitochondria. J Biol Chem. 2009 Jan 02; 284(1):46-55. PMID: 19001413.
      Citations: 37     Fields:    Translation:AnimalsCells
    58. Muller FL, Liu Y, Jernigan A, Borchelt D, Richardson A, Van Remmen H. MnSOD deficiency has a differential effect on disease progression in two different ALS mutant mouse models. Muscle Nerve. 2008 Sep; 38(3):1173-83. PMID: 18720509.
      Citations: 15     Fields:    Translation:Animals
    59. Pierce A, Mirzaei H, Muller F, De Waal E, Taylor AB, Leonard S, Van Remmen H, Regnier F, Richardson A, Chaudhuri A. GAPDH is conformationally and functionally altered in association with oxidative stress in mouse models of amyotrophic lateral sclerosis. J Mol Biol. 2008 Oct 24; 382(5):1195-210. PMID: 18706911.
      Citations: 25     Fields:    Translation:AnimalsCells
    60. Abdul-Ghani MA, Muller FL, Liu Y, Chavez AO, Balas B, Zuo P, Chang Z, Tripathy D, Jani R, Molina-Carrion M, Monroy A, Folli F, Van Remmen H, DeFronzo RA. Deleterious action of FA metabolites on ATP synthesis: possible link between lipotoxicity, mitochondrial dysfunction, and insulin resistance. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E678-85. PMID: 18593850.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    61. Han ES, Muller FL, Pérez VI, Qi W, Liang H, Xi L, Fu C, Doyle E, Hickey M, Cornell J, Epstein CJ, Roberts LJ, Van Remmen H, Richardson A. The in vivo gene expression signature of oxidative stress. Physiol Genomics. 2008 Jun 12; 34(1):112-26. PMID: 18445702.
      Citations: 84     Fields:    Translation:AnimalsCells
    62. Muller FL, Liu Y, Abdul-Ghani MA, Lustgarten MS, Bhattacharya A, Jang YC, Van Remmen H. High rates of superoxide production in skeletal-muscle mitochondria respiring on both complex I- and complex II-linked substrates. Biochem J. 2008 Jan 15; 409(2):491-9. PMID: 17916065.
      Citations: 59     Fields:    Translation:AnimalsCells
    63. Muller FL, Song W, Jang YC, Liu Y, Sabia M, Richardson A, Van Remmen H. Denervation-induced skeletal muscle atrophy is associated with increased mitochondrial ROS production. Am J Physiol Regul Integr Comp Physiol. 2007 Sep; 293(3):R1159-68. PMID: 17584954.
      Citations: 131     Translation:AnimalsCells
    64. Bourdel-Marchasson I, Biran M, Dehail P, Traissac T, Muller F, Jenn J, Raffard G, Franconi JM, Thiaudiere E. Muscle phosphocreatine post-exercise recovery rate is related to functional evaluation in hospitalized and community-living older people. J Nutr Health Aging. 2007 May-Jun; 11(3):215-21. PMID: 17508097.
      Citations: 2     Fields:    Translation:HumansCells
    65. Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H. Trends in oxidative aging theories. Free Radic Biol Med. 2007 Aug 15; 43(4):477-503. PMID: 17640558.
      Citations: 322     Fields:    Translation:HumansAnimalsCells
    66. Muller FL, Song W, Liu Y, Chaudhuri A, Pieke-Dahl S, Strong R, Huang TT, Epstein CJ, Roberts LJ, Csete M, Faulkner JA, Van Remmen H. Absence of CuZn superoxide dismutase leads to elevated oxidative stress and acceleration of age-dependent skeletal muscle atrophy. Free Radic Biol Med. 2006 Jun 01; 40(11):1993-2004. PMID: 16716900.
      Citations: 176     Fields:    
    67. Mansouri A, Muller FL, Liu Y, Ng R, Faulkner J, Hamilton M, Richardson A, Huang TT, Epstein CJ, Van Remmen H. Alterations in mitochondrial function, hydrogen peroxide release and oxidative damage in mouse hind-limb skeletal muscle during aging. Mech Ageing Dev. 2006 Mar; 127(3):298-306. PMID: 16405961.
      Citations: 78     Fields:    Translation:AnimalsCells
    68. Muller F. H(2)S-induced ectothermy: relevance to aging. Rejuvenation Res. 2005; 8(3):135-7. PMID: 16144467.
      Citations:    Fields:    Translation:Animals
    69. Muller FL, Liu Y, Van Remmen H. Complex III releases superoxide to both sides of the inner mitochondrial membrane. J Biol Chem. 2004 Nov 19; 279(47):49064-73. PMID: 15317809.
      Citations: 305     Fields:    Translation:AnimalsCells
    70. Pidoux G, Guibourdenche J, Frendo JL, Gerbaud P, Conti M, Luton D, Muller F, Evain-Brion D. Impact of trisomy 21 on human trophoblast behaviour and hormonal function. Placenta. 2004 Apr; 25 Suppl A:S79-84. PMID: 15033312.
      Citations: 5     Fields:    Translation:HumansCells
    71. Kramer DM, Roberts AG, Muller F, Cape J, Bowman MK. Q-cycle bypass reactions at the Qo site of the cytochrome bc1 (and related) complexes. Methods Enzymol. 2004; 382:21-45. PMID: 15047094.
      Citations: 17     Fields:    Translation:Cells
    72. Muller FL, Roberts AG, Bowman MK, Kramer DM. Architecture of the Qo site of the cytochrome bc1 complex probed by superoxide production. Biochemistry. 2003 Jun 03; 42(21):6493-9. PMID: 12767232.
      Citations: 35     Fields:    Translation:AnimalsCells
    73. Muller F, Crofts AR, Kramer DM. Multiple Q-cycle bypass reactions at the Qo site of the cytochrome bc1 complex. Biochemistry. 2002 Jun 25; 41(25):7866-74. PMID: 12069575.
      Citations: 61     Fields:    Translation:AnimalsCells
    74. Frendo JL, Thérond P, Bird T, Massin N, Muller F, Guibourdenche J, Luton D, Vidaud M, Anderson WB, Evain-Brion D. Overexpression of copper zinc superoxide dismutase impairs human trophoblast cell fusion and differentiation. Endocrinology. 2001 Aug; 142(8):3638-48. PMID: 11459813.
      Citations: 14     Fields:    Translation:HumansCells
    75. Lia-Baldini AS, Muller F, Taillandier A, Gibrat JF, Mouchard M, Robin B, Simon-Bouy B, Serre JL, Aylsworth AS, Bieth E, Delanote S, Freisinger P, Hu JC, Krohn HP, Nunes ME, Mornet E. A molecular approach to dominance in hypophosphatasia. Hum Genet. 2001 Jul; 109(1):99-108. PMID: 11479741.
      Citations: 25     Fields:    Translation:HumansCells
    76. Muller F. The nature and mechanism of superoxide production by the electron transport chain: Its relevance to aging. J Am Aging Assoc. 2000 Oct; 23(4):227-53. PMID: 23604868.
      Citations: 44     
    77. Tyler JW, Hancock DD, Wilson L, Muller F, Krytenberg D, Bradish S. Effect of passive transfer status and vaccination with Escherichia coli (J5) on mortality in comingled dairy calves. J Vet Intern Med. 1999 Jan-Feb; 13(1):36-9. PMID: 10052061.
      Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
    78. Sokol AI, Kramer RL, Yaron Y, O'Brien JE, Muller F, Johnson MP, Evans MI. Age-specific variation in aneuploidy incidence among biochemical screening programs. Am J Obstet Gynecol. 1998 Oct; 179(4):971-3. PMID: 9790381.
      Citations: 1     Fields:    Translation:Humans
    79. Rowland FS, Blake DR, Larsen BR, Lindskog A, Peterson PJ, Williams WP, Wallington TJ, Pilling MJ, Carslaw N, Creasey DJ, Heard DE, Jacobs P, Lee J, Lewis AC, McQuaid JB, Stockwell WR, Frank H, Sacco P, Cocheo V, Lynge E, Andersen A, Nilsson R, Barlow L, Pukkala E, Nordlinder R, Boffetta P, Grandjean P, Heikkil P, Hürte LG, Jakobsson R, Lundberg I, Moen B, Partanen T, Riise T, Borowiak A, De Saeger E, Schnitzler KG, Gravenhorst G, Jacobi HW, Moelders S, Lammel G, Busch G, Beese FO, Dentener FJ, Feichter J, Fraedrich K, Roelofs GJ, Friedrich R, Reis S, Voehringer F, Simpson D, Moussiopoulos N, Sahm P, Tourlou PM, Salmons R, Papameletiou D, Maqueda JM, Suhr PB, Bell W, Paton-Walsh C, Woods PT, Partridge RH, Slemr J, Slemr F, Schmidbauer N, Ravishankara AR, Jenkin ME, de Leeuw G, van Eijk AM, Flossmann AI, Wobrock W, Mestayer PG, Tranchant B, Ljungström E, Karlsson R, Larsen SE, Roemer M, Builtjes PJ, Koffi B, Koffi EN, De Saeger E, Ro-Poulsen H, Mikkelsen TN, Hummelshøj P, Hovmand MF, Simoneit BR, van der Meulen A, Meyer MB, Berndt T, Böge O, Stratmann F, Cass GR, Harrison RM, Shi JP, Hoffmann T, Warscheid B, Bandur R, Marggraf U, Nigge W, Kamens R, Jang M, Strommen M, Chien CJ, Leach K, Ammann M, Kalberer M, Arens F, Lavanchy V, Gâggeler HW, Baltensperger U, Davies JA, Cox RA, Alonso SG, Pastor RP, Argüello GA, Willner H, Berndt T, Böge O, Bogillo VI, Pokrovskiy VA, Kuraev OV, Gozhyk PF, Bolzacchini E, Bruschi M, Fantucci P, Meinardi S, Orlandi M, Rindone B, Bolzacchini E, Bohn B, Rindone B, Bruschi M, Zetzsch C, Brussol C, Duane M, Larsen B, Carlier P, Kotzias D, Caracena AB, Aznar AM, Ferradás EG, Christensen CS, Skov H, Hummelshøj P, Jensen NO, Lohse C, Cocheo V, Sacco P, Chatzis C, Cocheo V, Sacco P, Boaretto C, Quaglio F, Zaratin L, Pagani D, Cocheo L, Cocheo V, Asnar AM, Baldan A, Ballesta PP, Boaretto C, Caracena AB, Ferradas EG, Gonzalez-Flesca N, Goelen E, Hansen AB, Sacco P, De Saeger E, Skov H, Consonni V, Gramatica P, Santagostino A, Galvani P, Bolzacchini E, Consonni V, Gramatica P, Todeschini R, Dippel G, Reinhardt H, Zellner R, Dämmer K, Bednarek G, Breil M, Zellner R, Febo A, Allegrini I, Giliberti C, Perrino C, Fogg PG, Geiger H, Barnes I, Becker KH, Maurer T, Geyskens F, Bormans R, Lambrechts M, Goelen E, Giese M, Frank H, Glasius M, Hornung P, Jacobsen JK, Klausen HS, Klitgaard KC, Møller CK, Petersen AP, Petersen LS, Wessel S, Hansen TS, Lohse C, Boaretto E, Heinemeier J, Glasius M, Di Bella D, Lahaniati M, Calogirou A, Jensen NR, Hjorth J, Kotzias D, Larsen BR, Gonzalez-Flesca N, Cicolella A, Bates M, Bastin E, Gurbanov MA, Akhmedly KM, Balayev VS, Haselmann KF, Ketola R, Laturnus F, Lauritsen FR, Grøn C, Herrmann H, Ervens B, Reese A, Umschlag T, Wicktor F, Zellner R, Herrmann H, Umschlag T, Müller K, Bolzacchini E, Meinardi S, Rindone B, Jenkin ME, Hayman GD, Jensen NO, Courtney M, Hummelshøj P, Christensen CS, Larsen BR, Johnson MS, Hegelund F, Nelander B, Kirchner F, Klotz B, Barnes I, Sørensen S, Becker KH, Etzkorn T, Platt U, Wirtz K, Martín-Reviejo M, Laturnus F, Martinez E, Cabañas B, Aranda A, Martín P, Salgado S, Rodriguez D, Masclet P, Jaffrezo JL, Hillamo R, Mellouki A, Le Calvé S, Le Bras G, Moriarty J, O'Donnell S, Wenger J, Sidebottom H, Mingarrol MT, Cosin S, Pastor RP, Alonso SG, Sanz MJ, Bravo I, Gonzalez D, Pérez MA, Mustafaev I, Mammadova S, Noda J, Hallquist M, Langer S, Ljungström E, Nohara K, Kutsuna S, Ibusuki T, Oehme M, Kölliker S, Brombacher S, Merz L, Pastor RP, Alonso SG, Cabezas AQ, Peeters J, Vereecken L, El Yazal J, Pfeffer HU, Breuer L, Platz J, Nielsen OJ, Sehested J, Wallington TJ, Ball JC, Hurley MD, Straccia AM, Schneider WF, Pérez-Casany MP, Nebot-Gil I, Sánchez-Marín J, Putz E, Folberth G, Pfister G, Weissflog L, Elansky NP, Sørensen S, Barnes I, Becker KH, Shao M, Heiden AC, Kley D, Rockel P, Wildt J, Silva GV, Vasconcelos MT, Fernandes EO, Santos AM, Skov H, Hansen A, Løfstrøm P, Lorenzen G, Stabel JR, Wolkoff P, Pedersen T, Strom AB, Skov H, Hertel O, et al. Abstracts of the 6th FECS Conference 1998 Lectures. Environ Sci Pollut Res Int. 1998; 5(3):119-96. PMID: 19002640.
      Citations: 1     Fields:    
    80. Muller F, Tyler JW, Parish SM, Johnson KA, Krytenberg DS, Wilson LK. Stability of gamma-glutamyltransferase activity in calf sera after refrigerated or frozen storage. Am J Vet Res. 1997 Apr; 58(4):354-5. PMID: 9099377.
      Citations:    Fields:    Translation:Animals
    81. Pasquier B, Lachard A, Pasquier D, Muller F, Couderc P, Courel-Vidard MN, Girard N, Delpech B. [Costal micrometastasis from a cerebral astrocytoma. Immunohistochemical detection (author's transl)]. Arch Anat Cytol Pathol. 1982; 30(1):50-5. PMID: 6282226.
      Citations: 1     Fields:    Translation:Humans
    82. Erratum. Nature. 475:254.
    83. Erratum. Nature. 525:278.
    84. The nature and mechanism of superoxide production by the electron transport chain. Journal of the American Aging Association. 23:227-253.
    85. An objective appraisal of the free radical theory of aging. 177-202.
    86. Collateral Lethality. Trends in Cancer. 1:161-173.
    87. SF2312 is a natural phosphonate inhibitor of enolase. Nature Chemical Biology.
    88. ENOblock does not inhibit the activity of the glycolytic enzyme enolase. PLoS One. 11.
    89. Functional regulation of FoxO1 in neural stem cell differentiation. Cell Death and Differentiation. 22:2034-2045.
    90. Erratum. Nature Medicine. 18:1857.
    91. Does oxidative stress determine lifespan?. 477-498.
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