XIAOBING SHI

TitleAssociate Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen K, Chen Z, Wu D, Zhang L, Lin X, Su J, Rodriguez B, Xi Y, Xia Z, Chen X, Shi X, Wang Q, Li W. Broad H3K4me3 is associated with increased transcription elongation and enhancer activity at tumor-suppressor genes. Nat Genet. 2015 Oct; 47(10):1149-57. PMID: 26301496.
      Citations: 60     Fields:    Translation:HumansCells
    2. Zhang X, Huang Y, Shi X. Emerging roles of lysine methylation on non-histone proteins. Cell Mol Life Sci. 2015 Nov; 72(22):4257-72. PMID: 26227335.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    3. Wen H, Li Y, Li H, Shi X. ZMYND11: an H3.3-specific reader of H3K36me3. . 2014; 13(14):2153-4. PMID: 24963723.
      Citations:    
    4. Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W, Li H, Shi X. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature. 2014 Apr 10; 508(7495):263-8. PMID: 24590075.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    5. Jiang Y, Trescott L, Holcomb J, Zhang X, Brunzelle J, Sirinupong N, Shi X, Yang Z. Structural insights into estrogen receptor a methylation by histone methyltransferase SMYD2, a cellular event implicated in estrogen signaling regulation. J Mol Biol. 2014 Oct 09; 426(20):3413-25. PMID: 24594358.
      Citations: 18     Fields:    Translation:HumansCells
    6. Klein BJ, Piao L, Xi Y, Rincon-Arano H, Rothbart SB, Peng D, Wen H, Larson C, Zhang X, Zheng X, Cortazar MA, Peña PV, Mangan A, Bentley DL, Strahl BD, Groudine M, Li W, Shi X, Kutateladze TG. The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep. 2014 Jan 30; 6(2):325-35. PMID: 24412361.
      Citations: 49     Fields:    Translation:HumansCells
    7. Poplawski A, Hu K, Lee W, Natesan S, Peng D, Carlson S, Shi X, Balaz S, Markley JL, Glass KC. Molecular insights into the recognition of N-terminal histone modifications by the BRPF1 bromodomain. J Mol Biol. 2014 Apr 17; 426(8):1661-76. PMID: 24333487.
      Citations: 24     Fields:    Translation:HumansCells
    8. Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X. Regulation of estrogen receptor a by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17284-9. PMID: 24101509.
      Citations: 44     Fields:    Translation:HumansCells
    9. Zhang H, Ma ZY, Zeng L, Tanaka K, Zhang CJ, Ma J, Bai G, Wang P, Zhang SW, Liu ZW, Cai T, Tang K, Liu R, Shi X, He XJ, Zhu JK. DTF1 is a core component of RNA-directed DNA methylation and may assist in the recruitment of Pol IV. Proc Natl Acad Sci U S A. 2013 May 14; 110(20):8290-5. PMID: 23637343.
      Citations: 51     Fields:    Translation:AnimalsCells
    10. Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev. 2012 Dec 15; 26(24):2749-62. PMID: 23249737.
      Citations: 52     Fields:    Translation:HumansCells
    11. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 01; 288(5):3174-83. PMID: 23229552.
      Citations: 29     Fields:    Translation:HumansCells
    12. Brien GL, Gambero G, O'Connell DJ, Jerman E, Turner SA, Egan CM, Dunne EJ, Jurgens MC, Wynne K, Piao L, Lohan AJ, Ferguson N, Shi X, Sinha KM, Loftus BJ, Cagney G, Bracken AP. Polycomb PHF19 binds H3K36me3 and recruits PRC2 and demethylase NO66 to embryonic stem cell genes during differentiation. Nat Struct Mol Biol. 2012 Dec; 19(12):1273-81. PMID: 23160351.
      Citations: 71     Fields:    Translation:AnimalsCells
    13. Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul; 4(7):462-79. PMID: 22820736.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    14. Qian W, Miki D, Zhang H, Liu Y, Zhang X, Tang K, Kan Y, La H, Li X, Li S, Zhu X, Shi X, Zhang K, Pontes O, Chen X, Liu R, Gong Z, Zhu JK. A histone acetyltransferase regulates active DNA demethylation in Arabidopsis. Science. 2012 Jun 15; 336(6087):1445-8. PMID: 22700931.
      Citations: 75     Fields:    Translation:AnimalsCells
    15. Zhang X, Wen H, Shi X. Lysine methylation: beyond histones. Acta Biochim Biophys Sin (Shanghai). 2012 Jan; 44(1):14-27. PMID: 22194010.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    16. Kuo AJ, Cheung P, Chen K, Zee BM, Kioi M, Lauring J, Xi Y, Park BH, Shi X, Garcia BA, Li W, Gozani O. NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell. 2011 Nov 18; 44(4):609-20. PMID: 22099308.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    17. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32. PMID: 21164480.
      Citations: 154     Fields:    Translation:HumansCells
    18. Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Lysine methylation of the NF-?B subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-?B signaling. Nat Immunol. 2011 Jan; 12(1):29-36. PMID: 21131967.
      Citations: 107     Fields:    Translation:HumansCells
    19. West LE, Roy S, Lachmi-Weiner K, Hayashi R, Shi X, Appella E, Kutateladze TG, Gozani O. The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. J Biol Chem. 2010 Nov 26; 285(48):37725-32. PMID: 20870725.
      Citations: 37     Fields:    Translation:HumansCells
    20. Kleine-Kohlbrecher D, Christensen J, Vandamme J, Abarrategui I, Bak M, Tommerup N, Shi X, Gozani O, Rappsilber J, Salcini AE, Helin K. A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Mol Cell. 2010 Apr 23; 38(2):165-78. PMID: 20346720.
      Citations: 90     Fields:    Translation:HumansCells
    21. Wen H, Li J, Song T, Lu M, Kan PY, Lee MG, Sha B, Shi X. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem. 2010 Mar 26; 285(13):9322-6. PMID: 20129925.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    22. McCord RA, Michishita E, Hong T, Berber E, Boxer LD, Kusumoto R, Guan S, Shi X, Gozani O, Burlingame AL, Bohr VA, Chua KF. SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. Aging (Albany NY). 2009 Jan 15; 1(1):109-21. PMID: 20157594.
      Citations: 121     Fields:    Translation:HumansCells
    23. Kachirskaia I, Shi X, Yamaguchi H, Tanoue K, Wen H, Wang EW, Appella E, Gozani O. Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. J Biol Chem. 2008 Dec 12; 283(50):34660-6. PMID: 18840612.
      Citations: 35     Fields:    Translation:HumansCells
    24. Zhang H, Gómez-García MR, Shi X, Rao NN, Kornberg A. Polyphosphate kinase 1, a conserved bacterial enzyme, in a eukaryote, Dictyostelium discoideum, with a role in cytokinesis. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16486-91. PMID: 17940044.
      Citations: 23     Fields:    Translation:AnimalsCells
    25. Shi X, Kachirskaia I, Yamaguchi H, West LE, Wen H, Wang EW, Dutta S, Appella E, Gozani O. Modulation of p53 function by SET8-mediated methylation at lysine 382. Mol Cell. 2007 Aug 17; 27(4):636-46. PMID: 17707234.
      Citations: 173     Fields:    Translation:HumansCells
    26. Lan F, Collins RE, De Cegli R, Alpatov R, Horton JR, Shi X, Gozani O, Cheng X, Shi Y. Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Nature. 2007 Aug 09; 448(7154):718-22. PMID: 17687328.
      Citations: 192     Fields:    Translation:HumansCells
    27. Huang W, Zhang H, Davrazou F, Kutateladze TG, Shi X, Gozani O, Prestwich GD. Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. J Am Chem Soc. 2007 May 23; 129(20):6498-506. PMID: 17469822.
      Citations: 17     Fields:    Translation:HumansCells
    28. Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, Gozani O. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem. 2007 Jan 26; 282(4):2450-5. PMID: 17142463.
      Citations: 114     Fields:    Translation:AnimalsCells
    29. Martin DG, Baetz K, Shi X, Walter KL, MacDonald VE, Wlodarski MJ, Gozani O, Hieter P, Howe L. The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Mol Cell Biol. 2006 Nov; 26(21):7871-9. PMID: 16923967.
      Citations: 78     Fields:    Translation:AnimalsCells
    30. Shi X, Hong T, Walter KL, Ewalt M, Michishita E, Hung T, Carney D, Peña P, Lan F, Kaadige MR, Lacoste N, Cayrou C, Davrazou F, Saha A, Cairns BR, Ayer DE, Kutateladze TG, Shi Y, Côté J, Chua KF, Gozani O. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006 Jul 06; 442(7098):96-9. PMID: 16728974.
      Citations: 384     Fields:    Translation:Cells
    31. Peña PV, Davrazou F, Shi X, Walter KL, Verkhusha VV, Gozani O, Zhao R, Kutateladze TG. Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Nature. 2006 Jul 06; 442(7098):100-3. PMID: 16728977.
      Citations: 286     Fields:    Translation:AnimalsCells
    32. Shi X, Gozani O. The fellowships of the INGs. J Cell Biochem. 2005 Dec 15; 96(6):1127-36. PMID: 16167330.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    33. Shi X, Kornberg A. Endopolyphosphatase in Saccharomyces cerevisiae undergoes post-translational activations to produce short-chain polyphosphates. FEBS Lett. 2005 Mar 28; 579(9):2014-8. PMID: 15792812.
      Citations: 7     Fields:    Translation:AnimalsCells
    34. Shi X, Rao NN, Kornberg A. Inorganic polyphosphate in Bacillus cereus: motility, biofilm formation, and sporulation. Proc Natl Acad Sci U S A. 2004 Dec 07; 101(49):17061-5. PMID: 15572452.
      Citations: 34     Fields:    Translation:Cells
    35. YEATS2 is a selective histone crotonylation reader. Cell Research. 26:629-632.
    36. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene.
    37. The Taf14 YEATS domain is a reader of histone crotonylation. Nature Chemical Biology. 12:396-398.
    38. PHF20 Readers Link Methylation of Histone H3K4 and p53 with H4K16 Acetylation. Cell Reports. 17:1158-1170.
    39. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Molecular Cell.
    40. The Histone Variant H3.3 in Transcriptional Regulation and Human Disease. Journal of Molecular Biology.
    41. Histone H3K4 methylation regulates deactivation of the spindle assembly checkpoint through direct binding of Mad2. Genes and Development. 30:1187-1197.
    42. G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nature Communications. 7.
    43. Molecular Coupling of Histone Crotonylation and Active Transcription by AF9 YEATS Domain. Molecular Cell. 62:181-193.
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