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VAHID AFSHAR-KHARGHAN

TitleProfessor
InstitutionMD Anderson
DepartmentPulmonary Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Saha B, Mathur T, Handley KF, Hu W, Afshar-Kharghan V, Sood AK, Jain A. OvCa-Chip microsystem recreates vascular endothelium-mediated platelet extravasation in ovarian cancer. Blood Adv. 2020 Jul 28; 4(14):3329-3342. PMID: 32717032.
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    2. Oncul S, Afshar-Kharghan V. The interaction between the complement system and hemostatic factors. Curr Opin Hematol. 2020 Jul 20. PMID: 32701617.
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    3. Afshar-Kharghan V. APC ameliorates pulmonary complications in cGVHD. Blood. 2019 08 29; 134(9):724-725. PMID: 31467078.
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    4. Ma Q, Li D, Vasquez HG, You MJ, Afshar-Kharghan V. Kidney Injury in Murine Models of Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2019 10; 25(10):1920-1924. PMID: 31271886.
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    5. Haemmerle M, Stone RL, Menter DG, Afshar-Kharghan V, Sood AK. The Platelet Lifeline to Cancer: Challenges and Opportunities. Cancer Cell. 2018 06 11; 33(6):965-983. PMID: 29657130.
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    6. Haemmerle M, Taylor ML, Gutschner T, Pradeep S, Cho MS, Sheng J, Lyons YM, Nagaraja AS, Dood RL, Wen Y, Mangala LS, Hansen JM, Rupaimoole R, Gharpure KM, Rodriguez-Aguayo C, Yim SY, Lee JS, Ivan C, Hu W, Lopez-Berestein G, Wong ST, Karlan BY, Levine DA, Liu J, Afshar-Kharghan V, Sood AK. Platelets reduce anoikis and promote metastasis by activating YAP1 signaling. Nat Commun. 2017 08 21; 8(1):310. PMID: 28827520.
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    7. Cho MS, Noh K, Haemmerle M, Li D, Park H, Hu Q, Hisamatsu T, Mitamura T, Mak SLC, Kunapuli S, Ma Q, Sood AK, Afshar-Kharghan V. Role of ADP receptors on platelets in the growth of ovarian cancer. Blood. 2017 09 07; 130(10):1235-1242. PMID: 28679740.
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    8. Hu Q, Hisamatsu T, Haemmerle M, Cho MS, Pradeep S, Rupaimoole R, Rodriguez-Aguayo C, Lopez-Berestein G, Wong STC, Sood AK, Afshar-Kharghan V. Role of Platelet-Derived Tgfß1 in the Progression of Ovarian Cancer. Clin Cancer Res. 2017 Sep 15; 23(18):5611-5621. PMID: 28611202.
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    9. Afshar-Kharghan V. Complement and clot. Blood. 2017 04 20; 129(16):2214-2215. PMID: 28428238.
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    10. Afshar-Kharghan V. The role of the complement system in cancer. J Clin Invest. 2017 Mar 01; 127(3):780-789. PMID: 28248200.
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    11. Afshar-Kharghan V. Atypical hemolytic uremic syndrome. Hematology Am Soc Hematol Educ Program. 2016 Dec 02; 2016(1):217-225. PMID: 27913483.
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    12. Hu Q, Cho MS, Thiagarajan P, Aung FM, Sood AK, Afshar-Kharghan V. A small amount of cyclooxygenase 2 (COX2) is constitutively expressed in platelets. Platelets. 2017 Jan; 28(1):99-102. PMID: 27534811.
      View in: PubMed
    13. Hu Q, Wang M, Cho MS, Wang C, Nick AM, Thiagarajan P, Aung FM, Han X, Sood AK, Afshar-Kharghan V. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clin. 2016 Dec; 6:76-81. PMID: 27453821.
      View in: PubMed
    14. Feng S, Kroll MH, Nick AM, Sood AK, Afshar-Kharghan V. Platelets are not hyperreactive in patients with ovarian cancer. Platelets. 2016 Nov; 27(7):716-718. PMID: 27185008.
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    15. Haemmerle M, Bottsford-Miller J, Pradeep S, Taylor ML, Choi HJ, Hansen JM, Dalton HJ, Stone RL, Cho MS, Nick AM, Nagaraja AS, Gutschner T, Gharpure KM, Mangala LS, Rupaimoole R, Han HD, Zand B, Armaiz-Pena GN, Wu SY, Pecot CV, Burns AR, Lopez-Berestein G, Afshar-Kharghan V, Sood AK. FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. J Clin Invest. 2016 05 02; 126(5):1885-96. PMID: 27064283.
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    16. Cho MS, Rupaimoole R, Choi HJ, Noh K, Chen J, Hu Q, Sood AK, Afshar-Kharghan V. Complement Component 3 Is Regulated by TWIST1 and Mediates Epithelial-Mesenchymal Transition. J Immunol. 2016 Feb 01; 196(3):1412-8. PMID: 26718342.
      View in: PubMed
    17. Wang R, Stone RL, Kaelber JT, Rochat RH, Nick AM, Vijayan KV, Afshar-Kharghan V, Schmid MF, Dong JF, Sood AK, Chiu W. Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. Proc Natl Acad Sci U S A. 2015 Nov 17; 112(46):14266-71. PMID: 26578771.
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    18. Ciurea SO, Thall PF, Milton DR, Barnes TH, Kongtim P, Carmazzi Y, López AA, Yap DY, Popat U, Rondon G, Lichtiger B, Aung F, Afshar-Kharghan V, Ma Q, Fernández-Viña M, Champlin RE, Cao K. Complement-Binding Donor-Specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant. 2015 Aug; 21(8):1392-8. PMID: 25985919.
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    19. Pemmaraju N, Sasaki K, Johnson D, Daver N, Afshar-Kharghan V, Chen M, Ahmed S, Colen RR, Kwon M, Huh Y, Borthakur G. Successful Treatment of Intracranial Hemorrhage with Recombinant Activated Factor VII in a Patient with Newly Diagnosed Acute Myeloid Leukemia: A Case Report and Review of the Literature. Front Oncol. 2015; 5:29. PMID: 25717439.
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    20. Bottsford-Miller J, Choi HJ, Dalton HJ, Stone RL, Cho MS, Haemmerle M, Nick AM, Pradeep S, Zand B, Previs RA, Pecot CV, Crane EK, Hu W, Lutgendorf SK, Afshar-Kharghan V, Sood AK. Differential platelet levels affect response to taxane-based therapy in ovarian cancer. Clin Cancer Res. 2015 Feb 01; 21(3):602-10. PMID: 25473001.
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    21. Feng S, Liang X, Kroll MH, Chung DW, Afshar-Kharghan V. von Willebrand factor is a cofactor in complement regulation. Blood. 2015 Feb 05; 125(6):1034-7. PMID: 25395424.
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    22. Afshar-Kharghan V. COMPLEMENTing the diagnosis of aHUS. Blood. 2014 Sep 11; 124(11):1699-700. PMID: 25214194.
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    23. Wu W, Merriman K, Nabaah A, Seval N, Afshar-Kharghan V, Yeung SC. Heparin-induced thrombocytopenia among patients of a comprehensive cancer center. SAGE Open Med Case Rep. 2014; 2:2050313X14533945. PMID: 27489647.
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    24. Lin RJ, Afshar-Kharghan V, Schafer AI. Paraneoplastic thrombocytosis: the secrets of tumor self-promotion. Blood. 2014 Jul 10; 124(2):184-7. PMID: 24868077.
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    25. Ma Q, Li D, Carreño R, Patenia R, Tsai KY, Xydes-Smith M, Alousi AM, Champlin RE, Sale GE, Afshar-Kharghan V. Complement component C3 mediates Th1/Th17 polarization in human T-cell activation and cutaneous GVHD. Bone Marrow Transplant. 2014 Jul; 49(7):972-6. PMID: 24777193.
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    26. Davis AN, Afshar-Kharghan V, Sood AK. Platelet effects on ovarian cancer. Semin Oncol. 2014 Jun; 41(3):378-84. PMID: 25023353.
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    27. Cho MS, Vasquez HG, Rupaimoole R, Pradeep S, Wu S, Zand B, Han HD, Rodriguez-Aguayo C, Bottsford-Miller J, Huang J, Miyake T, Choi HJ, Dalton HJ, Ivan C, Baggerly K, Lopez-Berestein G, Sood AK, Afshar-Kharghan V. Autocrine effects of tumor-derived complement. Cell Rep. 2014 Mar 27; 6(6):1085-1095. PMID: 24613353.
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    28. Nolasco L, Nolasco J, Feng S, Afshar-Kharghan V, Moake J. Human complement factor H is a reductase for large soluble von Willebrand factor multimers--brief report. Arterioscler Thromb Vasc Biol. 2013 Nov; 33(11):2524-8. PMID: 24008159.
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    29. Feng S, Liang X, Cruz MA, Vu H, Zhou Z, Pemmaraju N, Dong JF, Kroll MH, Afshar-Kharghan V. The interaction between factor H and Von Willebrand factor. PLoS One. 2013; 8(8):e73715. PMID: 23991205.
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    30. Feng S, Eyler SJ, Zhang Y, Maga T, Nester CM, Kroll MH, Smith RJ, Afshar-Kharghan V. Partial ADAMTS13 deficiency in atypical hemolytic uremic syndrome. Blood. 2013 Aug 22; 122(8):1487-93. PMID: 23847193.
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    31. Thiagarajan P, Afshar-Kharghan V. Platelet transfusion therapy. Hematol Oncol Clin North Am. 2013 Jun; 27(3):629-43. PMID: 23714315.
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    32. Feng S, Kroll MH, Nolasco L, Moake J, Afshar-Kharghan V. Complement activation in thrombotic microangiopathies. Br J Haematol. 2013 Feb; 160(3):404-6. PMID: 23116127.
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    33. Cho MS, Bottsford-Miller J, Vasquez HG, Stone R, Zand B, Kroll MH, Sood AK, Afshar-Kharghan V. Platelets increase the proliferation of ovarian cancer cells. Blood. 2012 Dec 06; 120(24):4869-72. PMID: 22966171.
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    34. Kroll MH, Afshar-Kharghan V. Platelets in pulmonary vascular physiology and pathology. Pulm Circ. 2012 Jul; 2(3):291-308. PMID: 23130099.
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    35. Ma Q, Li D, Nurieva R, Patenia R, Bassett R, Cao W, Alekseev AM, He H, Molldrem JJ, Kroll MH, Champlin RE, Sale GE, Afshar-Kharghan V. Reduced graft-versus-host disease in C3-deficient mice is associated with decreased donor Th1/Th17 differentiation. Biol Blood Marrow Transplant. 2012 Aug; 18(8):1174-81. PMID: 22664751.
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    36. Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012 Feb 16; 366(7):610-8. PMID: 22335738.
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    37. Zalpour A, Kroll MH, Afshar-Kharghan V, Yusuf SW, Escalante C. Role of factor xa inhibitors in cancer-associated thrombosis: any new data? Adv Hematol. 2011; 2011:196135. PMID: 22013445.
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    38. Divakaran V, Mehta S, Yao D, Hassan S, Simpson S, Wiegerinck E, Swinkels DW, Mann DL, Afshar-Kharghan V. Hepcidin in anemia of chronic heart failure. Am J Hematol. 2011 Jan; 86(1):107-9. PMID: 21080339.
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    39. Hanzelka KM, Zalpour A, Afshar-Kharghan V, Fitousis K, Anderlini P, Yeung SC. Severe thrombosis and acute thrombocytopenia in a cancer patient. Am J Hematol. 2010 Nov; 85(11):887-90. PMID: 20721891.
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    40. Seo N, Russell BH, Rivera JJ, Liang X, Xu X, Afshar-Kharghan V, Höök M. An engineered alpha1 integrin-binding collagenous sequence. J Biol Chem. 2010 Oct 01; 285(40):31046-54. PMID: 20675378.
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    41. Gushiken FC, Han H, Li J, Rumbaut RE, Afshar-Kharghan V. Abnormal platelet function in C3-deficient mice. J Thromb Haemost. 2009 May; 7(5):865-70. PMID: 19291167.
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    42. Kulkarni PA, Afshar-Kharghan V. Anticomplement therapy. Biologics. 2008 Dec; 2(4):671-85. PMID: 19707448.
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    43. Mnjoyan Z, Li J, Afshar-Kharghan V. Factor H binds to platelet integrin alphaIIbbeta3. Platelets. 2008 Nov; 19(7):512-9. PMID: 18979363.
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    44. Afshar-Kharghan V. Unleashed platelets in aHUS. Blood. 2008 Jun 01; 111(11):5266. PMID: 18502839.
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    45. Jelinek J, Li J, Mnjoyan Z, Issa JP, Prchal JT, Afshar-Kharghan V. Epigenetic control of PRV-1 expression on neutrophils. Exp Hematol. 2007 Nov; 35(11):1677-83. PMID: 17976520.
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    46. Diz-Kucukkaya R, Inanc M, Afshar-Kharghan V, Zhang QE, López JA, Pekcelen Y. P-selectin glycoprotein ligand-1 VNTR polymorphisms and risk of thrombosis in the antiphospholipid syndrome. Ann Rheum Dis. 2007 Oct; 66(10):1378-80. PMID: 17545190.
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    47. Luo SZ, Mo X, Afshar-Kharghan V, Srinivasan S, López JA, Li R. Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet. Blood. 2007 Jan 15; 109(2):603-9. PMID: 17008541.
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    48. Mnjoyan Z, Yoon D, Li J, Delhommeau F, Afshar-Kharghan V. The effect of the JAK2 V617F mutation on PRV-1 expression. Haematologica. 2006 Mar; 91(3):411-2. PMID: 16503546.
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    49. Afshar-Kharghan V, Thiagarajan P. Leukocyte adhesion and thrombosis. Curr Opin Hematol. 2006 Jan; 13(1):34-9. PMID: 16319685.
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    50. Del Conde I, Crúz MA, Zhang H, López JA, Afshar-Kharghan V. Platelet activation leads to activation and propagation of the complement system. J Exp Med. 2005 Mar 21; 201(6):871-9. PMID: 15781579.
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    51. Mnjoyan Z, Li J, Afshar-Kharghan V. Expression of polycythemia rubra vera-1 decreases the dependency of cells on growth factors for proliferation. Haematologica. 2005 Mar; 90(3):405-6. PMID: 15749675.
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    52. Afshar-Kharghan V, López JA, Gray LA, Padilla A, Borthakur G, Roberts SC, Pruthi RK, Tefferi A. Hemostatic gene polymorphisms and the prevalence of thrombotic complications in polycythemia vera and essential thrombocythemia. Blood Coagul Fibrinolysis. 2004 Jan; 15(1):21-4. PMID: 15166939.
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    53. Afshar-Kharghan V, Matijevic-Aleksic N, Ahn C, Boerwinkle E, Wu KK, López JA. The variable number of tandem repeat polymorphism of platelet glycoprotein Ibalpha and risk of coronary heart disease. Blood. 2004 Feb 01; 103(3):963-5. PMID: 14592833.
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    54. Meisel C, Afshar-Kharghan V, Cascorbi I, Laule M, Stangl V, Felix SB, Baumann G, López JA, Roots I, Stangl K. Role of Kozak sequence polymorphism of platelet glycoprotein Ibalpha as a risk factor for coronary artery disease and catheter interventions. J Am Coll Cardiol. 2001 Oct; 38(4):1023-7. PMID: 11583876.
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    55. Baker RI, Eikelboom J, Lofthouse E, Staples N, Afshar-Kharghan V, López JA, Shen Y, Berndt MC, Hankey G. Platelet glycoprotein Ibalpha Kozak polymorphism is associated with an increased risk of ischemic stroke. Blood. 2001 Jul 01; 98(1):36-40. PMID: 11418460.
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    56. Afshar-Kharghan V, Diz-Küçükkaya R, Ludwig EH, Marian AJ, López JA. Human polymorphism of P-selectin glycoprotein ligand 1 attributable to variable numbers of tandem decameric repeats in the mucinlike region. Blood. 2001 May 15; 97(10):3306-7. PMID: 11342464.
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    57. Afshar-Kharghan V, Craig FE, López JA. Bernard-Soulier syndrome in a patient doubly heterozygous for two frameshift mutations in the glycoprotein ib alpha gene. Br J Haematol. 2000 Sep; 110(4):919-24. PMID: 11054083.
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    58. Afshar-Kharghan V, Gineys G, Schade AJ, Sun L, Li CQ, McIntire LV, Dong JF, López JA. Necessity of conserved asparagine residues in the leucine-rich repeats of platelet glycoprotein Ib alpha for the proper conformation and function of the ligand-binding region. Biochemistry. 2000 Mar 28; 39(12):3384-91. PMID: 10727232.
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    59. Sachs UJ, Kiefel V, Böhringer M, Afshar-Kharghan V, Kroll H, Santoso S. Single amino acid substitution in human platelet glycoprotein Ibbeta is responsible for the formation of the platelet-specific alloantigen Iy(a). Blood. 2000 Mar 01; 95(5):1849-55. PMID: 10688847.
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    60. Afshar-Kharghan V, Li CQ, Khoshnevis-Asl M, López JA. Kozak sequence polymorphism of the glycoprotein (GP) Ibalpha gene is a major determinant of the plasma membrane levels of the platelet GP Ib-IX-V complex. Blood. 1999 Jul 01; 94(1):186-91. PMID: 10381512.
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    61. López JA, Andrews RK, Afshar-Kharghan V, Berndt MC. Bernard-Soulier syndrome. Blood. 1998 Jun 15; 91(12):4397-418. PMID: 9616133.
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    62. Dong JF, Li CQ, Sae-Tung G, Hyun W, Afshar-Kharghan V, López JA. The cytoplasmic domain of glycoprotein (GP) Ibalpha constrains the lateral diffusion of the GP Ib-IX complex and modulates von Willebrand factor binding. Biochemistry. 1997 Oct 14; 36(41):12421-7. PMID: 9376345.
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    63. Afshar-Kharghan V, López JA. Bernard-Soulier syndrome caused by a dinucleotide deletion and reading frameshift in the region encoding the glycoprotein Ib alpha transmembrane domain. Blood. 1997 Oct 01; 90(7):2634-43. PMID: 9326230.
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    64. A small amount of cyclooxygenase 2 (COX2) is constitutively expressed in platelets. Platelets. 1-4.
    65. Successful treatment of intracranial hemorrhage with recombinant activated factor VII in a patient with newly diagnosed acute myeloid leukemia. Frontiers in Oncology. 5.
    66. Electron cryotomography reveals ultrastructure alterations in platelets from patients with ovarian cancer. Proceedings of the National Academy of Sciences of the United States of America. 112:14266-14271.
    67. Complement component 3 is regulated by TWIST1 and mediates epithelial-mesenchymal transition. Journal of Immunology. 196:1412-1418.
    68. The authors reply. New England Journal of Medicine. 366:1840.
    69. Complement-Binding Donor-Specific Anti-HLA Antibodies and Risk of Primary Graft Failure in Hematopoietic Stem Cell Transplantation. Biology of Blood and Marrow Transplantation. 21:1392-1398.
    70. Platelets are not hyperreactive in patients with ovarian cancer. Platelets. 1-3.
    71. Lipid profile of platelets and platelet-derived microparticles in ovarian cancer. BBA Clinical. 6:76-81.
    72. Platelet polymorphisms. 281-307.
    73. FAK regulates platelet extravasation and tumor growth after antiangiogenic therapy withdrawal. Journal of Clinical Investigation. 126:1885-1896.
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