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SHAO-RUI CHEN

TitleAssociate Professor
InstitutionMD Anderson
DepartmentAnesthesiology & PeriOperative Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chen SR, Zhang J, Chen H, Pan HL. Streptozotocin-induced diabetic neuropathic pain is associated with potentiated calcium-permeable AMPA receptor activity in the spinal cord. J Pharmacol Exp Ther. 2019 Sep 03. PMID: 31481518.
      View in: PubMed
    2. Ma H, Chen SR, Chen H, Pan HL. Endogenous AT1 receptor-protein kinase C activity in the hypothalamus augments glutamatergic input and sympathetic outflow in hypertension. J Physiol. 2019 Aug; 597(16):4325-4340. PMID: 31241170.
      View in: PubMed
    3. Deng M, Chen SR, Chen H, Pan HL. a2d-1-Bound N-Methyl-D-aspartate Receptors Mediate Morphine-induced Hyperalgesia and Analgesic Tolerance by Potentiating Glutamatergic Input in Rodents. Anesthesiology. 2019 05; 130(5):804-819. PMID: 30839350.
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    4. Huang Y, Chen SR, Chen H, Pan HL. Endogenous transient receptor potential ankyrin 1 and vanilloid 1 activity potentiates glutamatergic input to spinal lamina I neurons in inflammatory pain. J Neurochem. 2019 May; 149(3):381-398. PMID: 30716174.
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    5. Deng M, Chen SR, Pan HL. Presynaptic NMDA receptors control nociceptive transmission at the spinal cord level in neuropathic pain. Cell Mol Life Sci. 2019 May; 76(10):1889-1899. PMID: 30788514.
      View in: PubMed
    6. Sun J, Chen SR, Chen H, Pan HL. µ-Opioid receptors in primary sensory neurons are essential for opioid analgesic effect on acute and inflammatory pain and opioid-induced hyperalgesia. J Physiol. 2019 Mar; 597(6):1661-1675. PMID: 30578671.
      View in: PubMed
    7. Chen Y, Chen SR, Chen H, Zhang J, Pan HL. Increased a2d-1-NMDA receptor coupling potentiates glutamatergic input to spinal dorsal horn neurons in chemotherapy-induced neuropathic pain. J Neurochem. 2019 Jan; 148(2):252-274. PMID: 30431158.
      View in: PubMed
    8. Deng M, Chen SR, Chen H, Luo Y, Dong Y, Pan HL. Mitogen-activated protein kinase signaling mediates opioid-induced presynaptic NMDA receptor activation and analgesic tolerance. J Neurochem. 2019 Jan; 148(2):275-290. PMID: 30444263.
      View in: PubMed
    9. Wang L, Chen SR, Ma H, Chen H, Hittelman WN, Pan HL. Regulating nociceptive transmission by VGluT2-expressing spinal dorsal horn neurons. J Neurochem. 2018 Nov; 147(4):526-540. PMID: 30203849.
      View in: PubMed
    10. Zhang J, Chen SR, Chen H, Pan HL. RE1-silencing transcription factor controls the acute-to-chronic neuropathic pain transition and Chrm2 receptor gene expression in primary sensory neurons. J Biol Chem. 2018 12 07; 293(49):19078-19091. PMID: 30327427.
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    11. Luo Y, Ma H, Zhou JJ, Li L, Chen SR, Zhang J, Chen L, Pan HL. Focal Cerebral Ischemia and Reperfusion Induce Brain Injury Through a2d-1-Bound NMDA Receptors. Stroke. 2018 10; 49(10):2464-2472. PMID: 30355118.
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    12. Ma H, Chen SR, Chen H, Zhou JJ, Li DP, Pan HL. a2d-1 couples to NMDA receptors in the hypothalamus to sustain sympathetic vasomotor activity in hypertension. J Physiol. 2018 Sep; 596(17):4269-4283. PMID: 29971791.
      View in: PubMed
    13. Ma H, Chen SR, Chen H, Li L, Li DP, Zhou JJ, Pan HL. a2d-1 Is Essential for Sympathetic Output and NMDA Receptor Activity Potentiated by Angiotensin II in the Hypothalamus. J Neurosci. 2018 Jul 11; 38(28):6388-6398. PMID: 29921713.
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    14. Chen J, Li L, Chen SR, Chen H, Xie JD, Sirrieh RE, MacLean DM, Zhang Y, Zhou MH, Jayaraman V, Pan HL. The a2d-1-NMDA Receptor Complex Is Critically Involved in Neuropathic Pain Development and Gabapentin Therapeutic Actions. Cell Rep. 2018 02 27; 22(9):2307-2321. PMID: 29490268.
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    15. Chen SR, Jin XG, Pan HL. Endogenous nitric oxide inhibits spinal NMDA receptor activity and pain hypersensitivity induced by nerve injury. Neuropharmacology. 2017 Oct; 125:156-165. PMID: 28754372.
      View in: PubMed
    16. Xie JD, Chen SR, Chen H, Pan HL. Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord. Neuropharmacology. 2017 Sep 01; 123:477-487. PMID: 28663117.
      View in: PubMed
    17. Chen SR, Chen H, Zhou JJ, Pradhan G, Sun Y, Pan HL, Li DP. Ghrelin receptors mediate ghrelin-induced excitation of agouti-related protein/neuropeptide Y but not pro-opiomelanocortin neurons. J Neurochem. 2017 08; 142(4):512-520. PMID: 28547758.
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    18. Li L, Chen SR, Chen H, Wen L, Hittelman WN, Xie JD, Pan HL. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Rep. 2016 05 17; 15(7):1376-1383. PMID: 27160909.
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    19. Zhang Y, Chen SR, Laumet G, Chen H, Pan HL. Nerve Injury Diminishes Opioid Analgesia through Lysine Methyltransferase-mediated Transcriptional Repression of µ-Opioid Receptors in Primary Sensory Neurons. J Biol Chem. 2016 Apr 15; 291(16):8475-85. PMID: 26917724.
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    20. Zhu Y, Chen SR, Pan HL. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. J Neurochem. 2016 Apr; 137(2):226-39. PMID: 26823384.
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    21. Laumet G, Garriga J, Chen SR, Zhang Y, Li DP, Smith TM, Dong Y, Jelinek J, Cesaroni M, Issa JP, Pan HL. G9a is essential for epigenetic silencing of K(+) channel genes in acute-to-chronic pain transition. Nat Neurosci. 2015 Dec; 18(12):1746-55. PMID: 26551542.
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    22. Zhang Y, Laumet G, Chen SR, Hittelman WN, Pan HL. Pannexin-1 Up-regulation in the Dorsal Root Ganglion Contributes to Neuropathic Pain Development. J Biol Chem. 2015 Jun 05; 290(23):14647-55. PMID: 25925949.
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    23. Li L, Li DP, Chen SR, Chen J, Hu H, Pan HL. Potentiation of high voltage-activated calcium channels by 4-aminopyridine depends on subunit composition. Mol Pharmacol. 2014 Dec; 86(6):760-72. PMID: 25267719.
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    24. Chen SR, Zhu L, Chen H, Wen L, Laumet G, Pan HL. Increased spinal cord Na?-K?-2Cl? cotransporter-1 (NKCC1) activity contributes to impairment of synaptic inhibition in paclitaxel-induced neuropathic pain. J Biol Chem. 2014 Nov 07; 289(45):31111-20. PMID: 25253692.
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    25. Qi Y, Wang J, Bomben VC, Li DP, Chen SR, Sun H, Xi Y, Reed JG, Cheng J, Pan HL, Noebels JL, Yeh ET. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death. Neuron. 2014 Sep 03; 83(5):1159-71. PMID: 25189211.
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    26. Chen SR, Zhou HY, Byun HS, Chen H, Pan HL. Casein kinase II regulates N-methyl-D-aspartate receptor activity in spinal cords and pain hypersensitivity induced by nerve injury. J Pharmacol Exp Ther. 2014 Aug; 350(2):301-12. PMID: 24898266.
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    27. Pachuau J, Li DP, Chen SR, Lee HA, Pan HL. Protein kinase CK2 contributes to diminished small conductance Ca2+-activated K+ channel activity of hypothalamic pre-sympathetic neurons in hypertension. J Neurochem. 2014 Sep; 130(5):657-67. PMID: 24806793.
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    28. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Differential regulation of primary afferent input to spinal cord by muscarinic receptor subtypes delineated using knockout mice. J Biol Chem. 2014 May 16; 289(20):14321-30. PMID: 24695732.
      View in: PubMed
    29. Li DP, Chen SR. Nitric oxide stimulates glutamatergic synaptic inputs to baroreceptor neurons through potentiation of Cav2.2-mediated Ca(2+) currents. Neurosci Lett. 2014 May 01; 567:57-62. PMID: 24686191.
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    30. Hu YM, Chen SR, Chen H, Pan HL. Casein kinase II inhibition reverses pain hypersensitivity and potentiated spinal N-methyl-D-aspartate receptor activity caused by calcineurin inhibitor. J Pharmacol Exp Ther. 2014 May; 349(2):239-47. PMID: 24610957.
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    31. Xiong W, Chen SR, He L, Cheng K, Zhao YL, Chen H, Li DP, Homanics GE, Peever J, Rice KC, Wu LG, Pan HL, Zhang L. Presynaptic glycine receptors as a potential therapeutic target for hyperekplexia disease. Nat Neurosci. 2014 Feb; 17(2):232-9. PMID: 24390226.
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    32. Bavencoffe A, Chen SR, Pan HL. Regulation of nociceptive transduction and transmission by nitric oxide. Vitam Horm. 2014; 96:1-18. PMID: 25189381.
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    33. Chen SR, Hu YM, Chen H, Pan HL. Calcineurin inhibitor induces pain hypersensitivity by potentiating pre- and postsynaptic NMDA receptor activity in spinal cords. J Physiol. 2014 Jan 01; 592(1):215-27. PMID: 24081160.
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    34. Petrov RR, Knight L, Chen SR, Wager-Miller J, McDaniel SW, Diaz F, Barth F, Pan HL, Mackie K, Cavasotto CN, Diaz P. Mastering tricyclic ring systems for desirable functional cannabinoid activity. Eur J Med Chem. 2013 Nov; 69:881-907. PMID: 24125850.
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    35. Chen SR, Zhou HY, Byun HS, Pan HL. Nerve injury increases GluA2-lacking AMPA receptor prevalence in spinal cords: functional significance and signaling mechanisms. J Pharmacol Exp Ther. 2013 Dec; 347(3):765-72. PMID: 24030012.
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    36. Guo YX, Li DP, Chen SR, Pan HL. Distinct intrinsic and synaptic properties of pre-sympathetic and pre-parasympathetic output neurons in Barrington's nucleus. J Neurochem. 2013 Aug; 126(3):338-48. PMID: 23647148.
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    37. Cai YQ, Chen SR, Pan HL. Upregulation of nuclear factor of activated T-cells by nerve injury contributes to development of neuropathic pain. J Pharmacol Exp Ther. 2013 Apr; 345(1):161-8. PMID: 23386250.
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    38. Zhou HY, Chen SR, Byun HS, Chen H, Li L, Han HD, Lopez-Berestein G, Sood AK, Pan HL. N-methyl-D-aspartate receptor- and calpain-mediated proteolytic cleavage of K+-Cl- cotransporter-2 impairs spinal chloride homeostasis in neuropathic pain. J Biol Chem. 2012 Sep 28; 287(40):33853-64. PMID: 22854961.
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    39. Zhao YL, Chen SR, Chen H, Pan HL. Chronic opioid potentiates presynaptic but impairs postsynaptic N-methyl-D-aspartic acid receptor activity in spinal cords: implications for opioid hyperalgesia and tolerance. J Biol Chem. 2012 Jul 20; 287(30):25073-85. PMID: 22679016.
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    40. Xiong W, Cui T, Cheng K, Yang F, Chen SR, Willenbring D, Guan Y, Pan HL, Ren K, Xu Y, Zhang L. Cannabinoids suppress inflammatory and neuropathic pain by targeting a3 glycine receptors. J Exp Med. 2012 Jun 04; 209(6):1121-34. PMID: 22585736.
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    41. Cao XH, Chen SR, Li L, Pan HL. Nerve injury increases brain-derived neurotrophic factor levels to suppress BK channel activity in primary sensory neurons. J Neurochem. 2012 Jun; 121(6):944-53. PMID: 22428625.
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    42. Li L, Cao XH, Chen SR, Han HD, Lopez-Berestein G, Sood AK, Pan HL. Up-regulation of Cavß3 subunit in primary sensory neurons increases voltage-activated Ca2+ channel activity and nociceptive input in neuropathic pain. J Biol Chem. 2012 Feb 17; 287(8):6002-13. PMID: 22187436.
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    43. Cao XH, Byun HS, Chen SR, Pan HL. Diabetic neuropathy enhances voltage-activated Ca2+ channel activity and its control by M4 muscarinic receptors in primary sensory neurons. J Neurochem. 2011 Nov; 119(3):594-603. PMID: 21883220.
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    44. Jin XG, Chen SR, Cao XH, Li L, Pan HL. Nitric oxide inhibits nociceptive transmission by differentially regulating glutamate and glycine release to spinal dorsal horn neurons. J Biol Chem. 2011 Sep 23; 286(38):33190-202. PMID: 21813646.
      View in: PubMed
    45. Zhou HY, Chen SR, Pan HL. Targeting N-methyl-D-aspartate receptors for treatment of neuropathic pain. Expert Rev Clin Pharmacol. 2011 May; 4(3):379-88. PMID: 21686074.
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    46. Chen SR, Chen H, Yuan WX, Pan HL. Increased presynaptic and postsynaptic a2-adrenoceptor activity in the spinal dorsal horn in painful diabetic neuropathy. J Pharmacol Exp Ther. 2011 Apr; 337(1):285-92. PMID: 21248068.
      View in: PubMed
    47. Chen SR, Chen H, Yuan WX, Wess J, Pan HL. Dynamic control of glutamatergic synaptic input in the spinal cord by muscarinic receptor subtypes defined using knockout mice. J Biol Chem. 2010 Dec 24; 285(52):40427-37. PMID: 20940295.
      View in: PubMed
    48. Zhou HY, Chen SR, Chen H, Pan HL. Functional plasticity of group II metabotropic glutamate receptors in regulating spinal excitatory and inhibitory synaptic input in neuropathic pain. J Pharmacol Exp Ther. 2011 Jan; 336(1):254-64. PMID: 20923868.
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    49. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltage-gated K+ channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem. 2010 Sep 01; 114(5):1460-75. PMID: 20557422.
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    50. Zhou HY, Chen SR, Chen H, Pan HL. Opioid-induced long-term potentiation in the spinal cord is a presynaptic event. J Neurosci. 2010 Mar 24; 30(12):4460-6. PMID: 20335482.
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    51. Li DP, Chen SR, Pan HL. Adenosine inhibits paraventricular pre-sympathetic neurons through ATP-dependent potassium channels. J Neurochem. 2010 Apr; 113(2):530-42. PMID: 20096091.
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    52. Wu ZZ, Li DP, Chen SR, Pan HL. Aminopyridines potentiate synaptic and neuromuscular transmission by targeting the voltage-activated calcium channel beta subunit. J Biol Chem. 2009 Dec 25; 284(52):36453-61. PMID: 19850918.
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    53. Li JQ, Chen SR, Chen H, Cai YQ, Pan HL. Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. J Neurochem. 2010 Jan; 112(1):162-72. PMID: 19840219.
      View in: PubMed
    54. Cai YQ, Chen SR, Han HD, Sood AK, Lopez-Berestein G, Pan HL. Role of M2, M3, and M4 muscarinic receptor subtypes in the spinal cholinergic control of nociception revealed using siRNA in rats. J Neurochem. 2009 Nov; 111(4):1000-10. PMID: 19780895.
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    55. Sun H, Li DP, Chen SR, Hittelman WN, Pan HL. Sensing of blood pressure increase by transient receptor potential vanilloid 1 receptors on baroreceptors. J Pharmacol Exp Ther. 2009 Dec; 331(3):851-9. PMID: 19726694.
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    56. Chen SR, Samoriski G, Pan HL. Antinociceptive effects of chronic administration of uncompetitive NMDA receptor antagonists in a rat model of diabetic neuropathic pain. Neuropharmacology. 2009 Aug; 57(2):121-6. PMID: 19422840.
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    57. Chen SR, Cai YQ, Pan HL. Plasticity and emerging role of BKCa channels in nociceptive control in neuropathic pain. J Neurochem. 2009 Jul; 110(1):352-62. PMID: 19457113.
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    58. Zhang HM, Chen SR, Cai YQ, Richardson TE, Driver LC, Lopez-Berestein G, Pan HL. Signaling mechanisms mediating muscarinic enhancement of GABAergic synaptic transmission in the spinal cord. Neuroscience. 2009 Feb 18; 158(4):1577-88. PMID: 19110040.
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    59. Yuan WX, Chen SR, Chen H, Pan HL. Stimulation of alpha(1)-adrenoceptors reduces glutamatergic synaptic input from primary afferents through GABA(A) receptors and T-type Ca(2+) channels. Neuroscience. 2009 Feb 18; 158(4):1616-24. PMID: 19068225.
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    60. Zhou HY, Chen SR, Chen H, Pan HL. The glutamatergic nature of TRPV1-expressing neurons in the spinal dorsal horn. J Neurochem. 2009 Jan; 108(1):305-18. PMID: 19012737.
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    61. Zhang HM, Chen SR, Pan HL. Effects of activation of group III metabotropic glutamate receptors on spinal synaptic transmission in a rat model of neuropathic pain. Neuroscience. 2009 Jan 23; 158(2):875-84. PMID: 19017536.
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    62. Zhou HY, Chen SR, Chen H, Pan HL. Sustained inhibition of neurotransmitter release from nontransient receptor potential vanilloid type 1-expressing primary afferents by mu-opioid receptor activation-enkephalin in the spinal cord. J Pharmacol Exp Ther. 2008 Nov; 327(2):375-82. PMID: 18669865.
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    63. Chen SR, Pan HL. Removing TRPV1-expressing primary afferent neurons potentiates the spinal analgesic effect of delta-opioid agonists on mechano-nociception. Neuropharmacology. 2008 Aug; 55(2):215-22. PMID: 18579164.
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    64. Wu ZZ, Chen SR, Pan HL. Distinct inhibition of voltage-activated Ca2+ channels by delta-opioid agonists in dorsal root ganglion neurons devoid of functional T-type Ca2+ currents. Neuroscience. 2008 Jun 02; 153(4):1256-67. PMID: 18434033.
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    65. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased C-fiber nociceptive input potentiates inhibitory glycinergic transmission in the spinal dorsal horn. J Pharmacol Exp Ther. 2008 Mar; 324(3):1000-10. PMID: 18079355.
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    66. Pan HL, Wu ZZ, Zhou HY, Chen SR, Zhang HM, Li DP. Modulation of pain transmission by G-protein-coupled receptors. Pharmacol Ther. 2008 Jan; 117(1):141-61. PMID: 17959251.
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    67. Zhang HM, Zhou HY, Chen SR, Gautam D, Wess J, Pan HL. Control of glycinergic input to spinal dorsal horn neurons by distinct muscarinic receptor subtypes revealed using knockout mice. J Pharmacol Exp Ther. 2007 Dec; 323(3):963-71. PMID: 17878406.
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    68. Yang Q, Chen SR, Li DP, Pan HL. Kv1.1/1.2 channels are downstream effectors of nitric oxide on synaptic GABA release to preautonomic neurons in the paraventricular nucleus. Neuroscience. 2007 Oct 26; 149(2):315-27. PMID: 17869444.
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    69. Chen SR, Pan HM, Richardson TE, Pan HL. Potentiation of spinal alpha(2)-adrenoceptor analgesia in rats deficient in TRPV1-expressing afferent neurons. Neuropharmacology. 2007 Jun; 52(8):1624-30. PMID: 17482651.
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    70. Chen SR, Prunean A, Pan HM, Welker KL, Pan HL. Resistance to morphine analgesic tolerance in rats with deleted transient receptor potential vanilloid type 1-expressing sensory neurons. Neuroscience. 2007 Mar 16; 145(2):676-85. PMID: 17239544.
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    71. Wang XL, Zhang HM, Chen SR, Pan HL. Altered synaptic input and GABAB receptor function in spinal superficial dorsal horn neurons in rats with diabetic neuropathy. J Physiol. 2007 Mar 15; 579(Pt 3):849-61. PMID: 17218355.
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    72. Zhou HY, Zhang HM, Chen SR, Pan HL. Increased nociceptive input rapidly modulates spinal GABAergic transmission through endogenously released glutamate. J Neurophysiol. 2007 Jan; 97(1):871-82. PMID: 17108089.
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    73. Zhang HM, Chen SR, Pan HL. Regulation of glutamate release from primary afferents and interneurons in the spinal cord by muscarinic receptor subtypes. J Neurophysiol. 2007 Jan; 97(1):102-9. PMID: 17050831.
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    74. Wu ZZ, Chen SR, Pan HL. Signaling mechanisms of down-regulation of voltage-activated Ca2+ channels by transient receptor potential vanilloid type 1 stimulation with olvanil in primary sensory neurons. Neuroscience. 2006 Aug 11; 141(1):407-19. PMID: 16678970.
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    75. Chen SR, Pan HL. Blocking mu opioid receptors in the spinal cord prevents the analgesic action by subsequent systemic opioids. Brain Res. 2006 Apr 07; 1081(1):119-25. PMID: 16499888.
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    76. Chen SR, Pan HL. Loss of TRPV1-expressing sensory neurons reduces spinal mu opioid receptors but paradoxically potentiates opioid analgesia. J Neurophysiol. 2006 May; 95(5):3086-96. PMID: 16467418.
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    77. Wang XL, Zhang HM, Li DP, Chen SR, Pan HL. Dynamic regulation of glycinergic input to spinal dorsal horn neurones by muscarinic receptor subtypes in rats. J Physiol. 2006 Mar 01; 571(Pt 2):403-13. PMID: 16410279.
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    78. Zhang HM, Chen SR, Matsui M, Gautam D, Wess J, Pan HL. Opposing functions of spinal M2, M3, and M4 receptor subtypes in regulation of GABAergic inputs to dorsal horn neurons revealed by muscarinic receptor knockout mice. Mol Pharmacol. 2006 Mar; 69(3):1048-55. PMID: 16365281.
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    79. Finnegan TF, Chen SR, Pan HL. Mu opioid receptor activation inhibits GABAergic inputs to basolateral amygdala neurons through Kv1.1/1.2 channels. J Neurophysiol. 2006 Apr; 95(4):2032-41. PMID: 16306173.
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    80. Chen YP, Chen SR, Pan HL. Effect of morphine on deep dorsal horn projection neurons depends on spinal GABAergic and glycinergic tone: implications for reduced opioid effect in neuropathic pain. J Pharmacol Exp Ther. 2005 Nov; 315(2):696-703. PMID: 16033910.
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    81. Chen SR, Pan HL. Effect of systemic and intrathecal gabapentin on allodynia in a new rat model of postherpetic neuralgia. Brain Res. 2005 Apr 25; 1042(1):108-13. PMID: 15823259.
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    82. Chen YP, Chen SR, Pan HL. Systemic morphine inhibits dorsal horn projection neurons through spinal cholinergic system independent of descending pathways. J Pharmacol Exp Ther. 2005 Aug; 314(2):611-7. PMID: 15845859.
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    83. Chen SR, Wess J, Pan HL. Functional activity of the M2 and M4 receptor subtypes in the spinal cord studied with muscarinic acetylcholine receptor knockout mice. J Pharmacol Exp Ther. 2005 May; 313(2):765-70. PMID: 15665136.
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    84. Vydyanathan A, Wu ZZ, Chen SR, Pan HL. A-type voltage-gated K+ currents influence firing properties of isolectin B4-positive but not isolectin B4-negative primary sensory neurons. J Neurophysiol. 2005 Jun; 93(6):3401-9. PMID: 15647393.
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    85. Zhang HM, Li DP, Chen SR, Pan HL. M2, M3, and M4 receptor subtypes contribute to muscarinic potentiation of GABAergic inputs to spinal dorsal horn neurons. J Pharmacol Exp Ther. 2005 May; 313(2):697-704. PMID: 15640398.
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    86. Finnegan TF, Chen SR, Pan HL. Effect of the {mu} opioid on excitatory and inhibitory synaptic inputs to periaqueductal gray-projecting neurons in the amygdala. J Pharmacol Exp Ther. 2005 Feb; 312(2):441-8. PMID: 15388784.
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    87. Chen SR, Pan HL. Distinct roles of group III metabotropic glutamate receptors in control of nociception and dorsal horn neurons in normal and nerve-injured Rats. J Pharmacol Exp Ther. 2005 Jan; 312(1):120-6. PMID: 15375175.
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    88. Pan HL, Chen SR. Sensing tissue ischemia: another new function for capsaicin receptors? Circulation. 2004 Sep 28; 110(13):1826-31. PMID: 15364816.
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    89. Li DP, Atnip LM, Chen SR, Pan HL. Regulation of synaptic inputs to paraventricular-spinal output neurons by alpha2 adrenergic receptors. J Neurophysiol. 2005 Jan; 93(1):393-402. PMID: 15356178.
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    90. Wu ZZ, Chen SR, Pan HL. Differential sensitivity of N- and P/Q-type Ca2+ channel currents to a mu opioid in isolectin B4-positive and -negative dorsal root ganglion neurons. J Pharmacol Exp Ther. 2004 Dec; 311(3):939-47. PMID: 15280436.
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    91. Li DP, Chen SR, Pan HL. VR1 receptor activation induces glutamate release and postsynaptic firing in the paraventricular nucleus. J Neurophysiol. 2004 Sep; 92(3):1807-16. PMID: 15115794.
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    92. Pan YZ, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors excites a population of locus coeruleus-spinal neurons through presynaptic disinhibition. Brain Res. 2004 Jan 30; 997(1):67-78. PMID: 14715151.
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    93. Finnegan TF, Li DP, Chen SR, Pan HL. Activation of mu-opioid receptors inhibits synaptic inputs to spinally projecting rostral ventromedial medulla neurons. J Pharmacol Exp Ther. 2004 May; 309(2):476-83. PMID: 14724227.
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    94. Chen SR, Pan HL. Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors. Neuroscience. 2004; 125(1):141-8. PMID: 15051153.
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    95. Li DP, Chen SR, Finnegan TF, Pan HL. Signalling pathway of nitric oxide in synaptic GABA release in the rat paraventricular nucleus. J Physiol. 2004 Jan 01; 554(Pt 1):100-10. PMID: 14678495.
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    96. Chen SR, Pan HL. Antinociceptive effect of morphine, but not mu opioid receptor number, is attenuated in the spinal cord of diabetic rats. Anesthesiology. 2003 Dec; 99(6):1409-14. PMID: 14639157.
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    97. Chen SR, Pan HL. Up-regulation of spinal muscarinic receptors and increased antinociceptive effect of intrathecal muscarine in diabetic rats. J Pharmacol Exp Ther. 2003 Nov; 307(2):676-81. PMID: 12966147.
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    98. Zahner MR, Li DP, Chen SR, Pan HL. Cardiac vanilloid receptor 1-expressing afferent nerves and their role in the cardiogenic sympathetic reflex in rats. J Physiol. 2003 Sep 01; 551(Pt 2):515-23. PMID: 12829722.
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    99. Li DP, Chen SR, Pan HL. Angiotensin II stimulates spinally projecting paraventricular neurons through presynaptic disinhibition. J Neurosci. 2003 Jun 15; 23(12):5041-9. PMID: 12832527.
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    100. Pan HL, Khan GM, Alloway KD, Chen SR. Resiniferatoxin induces paradoxical changes in thermal and mechanical sensitivities in rats: mechanism of action. J Neurosci. 2003 Apr 01; 23(7):2911-9. PMID: 12684478.
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    101. Chen SR, Pan HL. Spinal GABAB receptors mediate antinociceptive actions of cholinergic agents in normal and diabetic rats. Brain Res. 2003 Mar 07; 965(1-2):67-74. PMID: 12591121.
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    102. Chen SR, Pan HL. Spinal nitric oxide contributes to the analgesic effect of intrathecal [d-pen2,d-pen5]-enkephalin in normal and diabetic rats. Anesthesiology. 2003 Jan; 98(1):217-22. PMID: 12503000.
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    103. Chen SR, Sweigart KL, Lakoski JM, Pan HL. Functional mu opioid receptors are reduced in the spinal cord dorsal horn of diabetic rats. Anesthesiology. 2002 Dec; 97(6):1602-8. PMID: 12459691.
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    104. Khan GM, Li DP, Chen SR, Pan HL. Role of spinal nitric oxide in the inhibitory effect of [D-Pen2, D-Pen5]-enkephalin on ascending dorsal horn neurons in normal and diabetic rats. J Pharmacol Exp Ther. 2002 Dec; 303(3):1021-8. PMID: 12438523.
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    105. Pan YZ, Li DP, Chen SR, Pan HL. Activation of delta-opioid receptors excites spinally projecting locus coeruleus neurons through inhibition of GABAergic inputs. J Neurophysiol. 2002 Nov; 88(5):2675-83. PMID: 12424303.
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    106. Li DP, Chen SR, Pan HL. Nitric oxide inhibits spinally projecting paraventricular neurons through potentiation of presynaptic GABA release. J Neurophysiol. 2002 Nov; 88(5):2664-74. PMID: 12424302.
      View in: PubMed
    107. Li DP, Chen SR, Pan YZ, Levey AI, Pan HL. Role of presynaptic muscarinic and GABA(B) receptors in spinal glutamate release and cholinergic analgesia in rats. J Physiol. 2002 Sep 15; 543(Pt 3):807-18. PMID: 12231640.
      View in: PubMed
    108. Chen SR, Pan HL. Hypersensitivity of spinothalamic tract neurons associated with diabetic neuropathic pain in rats. J Neurophysiol. 2002 Jun; 87(6):2726-33. PMID: 12037174.
      View in: PubMed
    109. Sandner-Kiesling A, Pan HL, Chen SR, James RL, DeHaven-Hudkins DL, Dewan DM, Eisenach JC. Effect of kappa opioid agonists on visceral nociception induced by uterine cervical distension in rats. Pain. 2002 Mar; 96(1-2):13-22. PMID: 11932057.
      View in: PubMed
    110. Pan HL, Chen SR. Myocardial ischemia recruits mechanically insensitive cardiac sympathetic afferents in cats. J Neurophysiol. 2002 Feb; 87(2):660-8. PMID: 11826035.
      View in: PubMed
    111. Chen SR, Wozniak KM, Slusher BS, Pan HL. Effect of 2-(phosphono-methyl)-pentanedioic acid on allodynia and afferent ectopic discharges in a rat model of neuropathic pain. J Pharmacol Exp Ther. 2002 Feb; 300(2):662-7. PMID: 11805230.
      View in: PubMed
    112. Khan GM, Chen SR, Pan HL. Role of primary afferent nerves in allodynia caused by diabetic neuropathy in rats. Neuroscience. 2002; 114(2):291-9. PMID: 12204199.
      View in: PubMed
    113. Bantel C, Tobin JR, Li X, Childers SR, Chen SR, Eisenach JC. Intrathecal adenosine following spinal nerve ligation in rat: short residence time in cerebrospinal fluid and no change in A(1) receptor binding. Anesthesiology. 2002 Jan; 96(1):103-8. PMID: 11753009.
      View in: PubMed
    114. Chen SR, Xu Z, Pan HL. Stereospecific effect of pregabalin on ectopic afferent discharges and neuropathic pain induced by sciatic nerve ligation in rats. Anesthesiology. 2001 Dec; 95(6):1473-9. PMID: 11748408.
      View in: PubMed
    115. Chen SR, Khan GM, Pan HL. Antiallodynic effect of intrathecal neostigmine is mediated by spinal nitric oxide in a rat model of diabetic neuropathic pain. Anesthesiology. 2001 Oct; 95(4):1007-12. PMID: 11605898.
      View in: PubMed
    116. Chen SR, Pan HL. Spinal endogenous acetylcholine contributes to the analgesic effect of systemic morphine in rats. Anesthesiology. 2001 Aug; 95(2):525-30. PMID: 11506129.
      View in: PubMed
    117. Pan HL, Deal DD, Xu Z, Chen SR. Differential responses of regional sympathetic activity and blood flow to visceral afferent stimulation. Am J Physiol Regul Integr Comp Physiol. 2001 Jun; 280(6):R1781-9. PMID: 11353683.
      View in: PubMed
    118. Pan HL, Chen SR, Scicli GM, Carretero OA. Cardiac interstitial bradykinin release during ischemia is enhanced by ischemic preconditioning. Am J Physiol Heart Circ Physiol. 2000 Jul; 279(1):H116-21. PMID: 10899048.
      View in: PubMed
    119. Xu Z, Chen SR, Eisenach J, Pan HL. Role of spinal muscarinic and nicotinic receptors in clonidine-induced nitric oxide release in a rat model of neuropathic pain. Brain Res. 2000 Apr 10; 861(2):390-8. PMID: 10760500.
      View in: PubMed
    120. Chen SR, Eisenach JC, McCaslin PP, Pan HL. Synergistic effect between intrathecal non-NMDA antagonist and gabapentin on allodynia induced by spinal nerve ligation in rats. Anesthesiology. 2000 Feb; 92(2):500-6. PMID: 10691238.
      View in: PubMed
    121. Zhao Z, Chen SR, Eisenach JC, Busija DW, Pan HL. Spinal cyclooxygenase-2 is involved in development of allodynia after nerve injury in rats. Neuroscience. 2000; 97(4):743-8. PMID: 10842019.
      View in: PubMed
    122. Chen SR, Eisenach JC, Pan HL. Intrathecal S-nitroso-N-acetylpenicillamine and L-cysteine attenuate nerve injury-induced allodynia through noradrenergic activation in rats. Neuroscience. 2000; 101(3):759-65. PMID: 11113324.
      View in: PubMed
    123. Pan HL, Longhurst JC, Eisenach JC, Chen SR. Role of protons in activation of cardiac sympathetic C-fibre afferents during ischaemia in cats. J Physiol. 1999 Aug 01; 518 ( Pt 3):857-66. PMID: 10420020.
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    124. Pan HL, Eisenach JC, Chen SR. Gabapentin suppresses ectopic nerve discharges and reverses allodynia in neuropathic rats. J Pharmacol Exp Ther. 1999 Mar; 288(3):1026-30. PMID: 10027839.
      View in: PubMed
    125. Pan HL, Chen SR, Eisenach JC. Intrathecal clonidine alleviates allodynia in neuropathic rats: interaction with spinal muscarinic and nicotinic receptors. Anesthesiology. 1999 Feb; 90(2):509-14. PMID: 9952159.
      View in: PubMed
    126. Pan HL, Chen SR, Eisenach JC. Role of spinal NO in antiallodynic effect of intrathecal clonidine in neuropathic rats. Anesthesiology. 1998 Dec; 89(6):1518-23. PMID: 9856728.
      View in: PubMed
    127. Presynaptic N-methyl-D-aspartate (NMDA) receptor activity is increased through protein kinase C in paclitaxel-induced neuropathic pain. Journal of Biological Chemistry. 291:19364-19373.
    128. Muscarinic receptor subtypes differentially control synaptic input and excitability of cerebellum-projecting medial vestibular nucleus neurons. Journal of Neurochemistry.
    129. Nerve injury diminishes opioid analgesia through lysine methyltransferase-mediated transcriptional repression of μ-opioid receptors in primary sensory neurons. Journal of Biological Chemistry. 291:8475-8485.
    130. Chloride Homeostasis Critically Regulates Synaptic NMDA Receptor Activity in Neuropathic Pain. Cell Reports. 15:1376-1383.
    131. G9a is essential for epigenetic silencing of K+ channel genes in acute-to-chronic pain transition. Nature Neuroscience.
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