KIMBERLY SCHLUNS

TitleAssociate Professor
InstitutionMD Anderson
DepartmentImmunology
Address7455 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou X, Yu J, Cheng X, Zhao B, Manyam GC, Zhang L, Schluns K, Li P, Wang J, Sun SC. The deubiquitinase Otub1 controls the activation of CD8+ T cells and NK cells by regulating IL-15-mediated priming. Nat Immunol. 2019 07; 20(7):879-889. PMID: 31182807.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Plote D, Choi W, Mokkapati S, Sundi D, Ferguson JE, Duplisea J, Parker NR, Yla-Herttuala S, Committee SCB, McConkey D, Schluns KS, Dinney CP. Inhibition of urothelial carcinoma through targeted type I interferon-mediated immune activation. Oncoimmunology. 2019; 8(5):e1577125. PMID: 31069136.
      Citations:    
    3. Santana Carrero RM, Beceren-Braun F, Rivas SC, Hegde SM, Gangadharan A, Plote D, Pham G, Anthony SM, Schluns KS. IL-15 is a component of the inflammatory milieu in the tumor microenvironment promoting antitumor responses. Proc Natl Acad Sci U S A. 2019 01 08; 116(2):599-608. PMID: 30587590.
      Citations: 9     Fields:    Translation:AnimalsCells
    4. Duplisea JJ, Mokkapati S, Plote D, Schluns KS, McConkey DJ, Yla-Herttuala S, Parker NR, Dinney CP. The development of interferon-based gene therapy for BCG unresponsive bladder cancer: from bench to bedside. World J Urol. 2019 Oct; 37(10):2041-2049. PMID: 30415317.
      Citations:    Fields:    Translation:Humans
    5. Hailemichael Y, Woods A, Fu T, He Q, Nielsen MC, Hasan F, Roszik J, Xiao Z, Vianden C, Khong H, Singh M, Sharma M, Faak F, Moore D, Dai Z, Anthony SM, Schluns KS, Sharma P, Engelhard VH, Overwijk WW. Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy. J Clin Invest. 2018 04 02; 128(4):1338-1354. PMID: 29480817.
      Citations: 11     Fields:    Translation:AnimalsCells
    6. Robinson TO, Schluns KS. The potential and promise of IL-15 in immuno-oncogenic therapies. Immunol Lett. 2017 10; 190:159-168. PMID: 28823521.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    7. Haymaker C, Yang Y, Wang J, Zou Q, Sahoo A, Alekseev A, Singh D, Ritthipichai K, Hailemichael Y, Hoang ON, Qin H, Schluns KS, Wang T, Overwijk WW, Sun SC, Bernatchez C, Kwak LW, Neelapu SS, Nurieva R. Absence of Grail promotes CD8+ T cell anti-tumour activity. Nat Commun. 2017 08 10; 8(1):239. PMID: 28798332.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    8. Anthony SM, Rivas SC, Colpitts SL, Howard ME, Stonier SW, Schluns KS. Inflammatory Signals Regulate IL-15 in Response to Lymphodepletion. J Immunol. 2016 06 01; 196(11):4544-52. PMID: 27183627.
      Citations: 4     Fields:    Translation:Animals
    9. Singh S, Schluns KS, Yang G, Anthony SM, Barry MA, Sastry KJ. Intranasal Vaccination Affords Localization and Persistence of Antigen-Specific CD8? T Lymphocytes in the Female Reproductive Tract. Vaccines (Basel). 2016 Mar 17; 4(1). PMID: 26999228.
      Citations:    
    10. Huang X, Li J, Dorta-Estremera S, Di Domizio J, Anthony SM, Watowich SS, Popkin D, Liu Z, Brohawn P, Yao Y, Schluns KS, Lanier LL, Cao W. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-? Production via the Generation of Reactive Oxygen Species. Cell Rep. 2015 Aug 18; 12(7):1120-32. PMID: 26257170.
      Citations: 14     Fields:    Translation:AnimalsCells
    11. Anthony SM, Howard ME, Hailemichael Y, Overwijk WW, Schluns KS. Soluble interleukin-15 complexes are generated in vivo by type I interferon dependent and independent pathways. PLoS One. 2015; 10(3):e0120274. PMID: 25756182.
      Citations: 5     Fields:    Translation:AnimalsCells
    12. Schluns KS, Klonowski KD. Protecting the borders: tissue-resident memory T cells on the front line. Front Immunol. 2015; 6:90. PMID: 25784912.
      Citations: 2     Fields:    
    13. Singh S, Yang G, Schluns KS, Anthony SM, Sastry KJ. Sublingual vaccination induces mucosal and systemic adaptive immunity for protection against lung tumor challenge. PLoS One. 2014; 9(3):e90001. PMID: 24599269.
      Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Singh S, Nehete P, Hanley P, Nehete B, Yang G, He H, Anthony SM, Schluns KS, Sastry KJ. Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models. Methods Mol Biol. 2014; 1184:417-55. PMID: 25048139.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Firth MA, Madera S, Beaulieu AM, Gasteiger G, Castillo EF, Schluns KS, Kubo M, Rothman PB, Vivier E, Sun JC. Nfil3-independent lineage maintenance and antiviral response of natural killer cells. J Exp Med. 2013 Dec 16; 210(13):2981-90. PMID: 24277151.
      Citations: 60     Fields:    Translation:AnimalsCells
    16. Lee PH, Puppi M, Schluns KS, Yu-Lee LY, Dong C, Lacorazza HD. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. J Immunol. 2014 Jan 01; 192(1):178-88. PMID: 24259505.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    17. Colpitts SL, Stonier SW, Stoklasek TA, Root SH, Aguila HL, Schluns KS, Lefrançois L. Transcriptional regulation of IL-15 expression during hematopoiesis. J Immunol. 2013 Sep 15; 191(6):3017-24. PMID: 23966624.
      Citations: 15     Fields:    Translation:AnimalsCells
    18. Puebla-Osorio N, Kim J, Ojeda S, Zhang H, Tavana O, Li S, Wang Y, Ma Q, Schluns KS, Zhu C. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. 2014 May 22; 33(21):2748-57. PMID: 23752193.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    19. Hailemichael Y, Dai Z, Jaffarzad N, Ye Y, Medina MA, Huang XF, Dorta-Estremera SM, Greeley NR, Nitti G, Peng W, Liu C, Lou Y, Wang Z, Ma W, Rabinovich B, Sowell RT, Schluns KS, Davis RE, Hwu P, Overwijk WW. Persistent antigen at vaccination sites induces tumor-specific CD8? T cell sequestration, dysfunction and deletion. Nat Med. 2013 Apr; 19(4):465-72. PMID: 23455713.
      Citations: 142     Fields:    Translation:AnimalsCells
    20. Castillo EF, Schluns KS. Regulating the immune system via IL-15 transpresentation. Cytokine. 2012 Sep; 59(3):479-90. PMID: 22795955.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    21. Wang X, Zhang Y, Yang XO, Nurieva RI, Chang SH, Ojeda SS, Kang HS, Schluns KS, Gui J, Jetten AM, Dong C. Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2. Immunity. 2012 Jan 27; 36(1):23-31. PMID: 22244845.
      Citations: 44     Fields:    Translation:AnimalsCells
    22. Roche CM, Smith A, Lindsey DR, Meher A, Schluns K, Arora A, Armitige LY, Jagannath C. The ?fbpA attenuated candidate vaccine from Mycobacterium tuberculosis, H37Rv primes for a stronger T-bet dependent Th1 immunity in mice. Tuberculosis (Edinb). 2011 Dec; 91 Suppl 1:S96-104. PMID: 22082615.
      Citations: 1     Fields:    Translation:AnimalsCells
    23. Ma W, Ortiz-Quintero B, Rangel R, McKeller MR, Herrera-Rodriguez S, Castillo EF, Schluns KS, Hall M, Zhang H, Suh WK, Okada H, Mak TW, Zhou Y, Blackburn MR, Martinez-Valdez H. Coordinate activation of inflammatory gene networks, alveolar destruction and neonatal death in AKNA deficient mice. Cell Res. 2011 Nov; 21(11):1564-77. PMID: 21606955.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Schluns KS. Window of opportunity for daclizumab. Nat Med. 2011 May; 17(5):545-7. PMID: 21546970.
      Citations: 7     Fields:    Translation:HumansCells
    25. Park HJ, Qin H, Cha SC, Sharma R, Chung Y, Schluns KS, Neelapu SS, Overwijk WW, Hwu P, Kwak LW. Induction of TLR4-dependent CD8+ T cell immunity by murine ß-defensin2 fusion protein vaccines. Vaccine. 2011 Apr 18; 29(18):3476-82. PMID: 21382485.
      Citations: 8     Fields:    Translation:AnimalsCells
    26. Castillo EF, Acero LF, Stonier SW, Zhou D, Schluns KS. Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation. Blood. 2010 Oct 07; 116(14):2494-503. PMID: 20581314.
      Citations: 25     Fields:    Translation:AnimalsCells
    27. Frasca L, Stonier SW, Overwijk WW, Schluns KS. Differential mechanisms of memory CD8 T cell maintenance by individual myeloid cell types. J Leukoc Biol. 2010 Jul; 88(1):69-78. PMID: 20354106.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Stonier SW, Schluns KS. Trans-presentation: a novel mechanism regulating IL-15 delivery and responses. Immunol Lett. 2010 Jan 04; 127(2):85-92. PMID: 19818367.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    29. Castillo EF, Stonier SW, Frasca L, Schluns KS. Dendritic cells support the in vivo development and maintenance of NK cells via IL-15 trans-presentation. J Immunol. 2009 Oct 15; 183(8):4948-56. PMID: 19786554.
      Citations: 45     Fields:    Translation:AnimalsCells
    30. Ma LJ, Acero LF, Zal T, Schluns KS. Trans-presentation of IL-15 by intestinal epithelial cells drives development of CD8alphaalpha IELs. J Immunol. 2009 Jul 15; 183(2):1044-54. PMID: 19553528.
      Citations: 46     Fields:    Translation:AnimalsCells
    31. Sikora AG, Jaffarzad N, Hailemichael Y, Gelbard A, Stonier SW, Schluns KS, Frasca L, Lou Y, Liu C, Andersson HA, Hwu P, Overwijk WW. IFN-alpha enhances peptide vaccine-induced CD8+ T cell numbers, effector function, and antitumor activity. J Immunol. 2009 Jun 15; 182(12):7398-407. PMID: 19494262.
      Citations: 49     Fields:    Translation:AnimalsCells
    32. Overwijk WW, Schluns KS. Functions of ?C cytokines in immune homeostasis: current and potential clinical applications. Clin Immunol. 2009 Aug; 132(2):153-65. PMID: 19428306.
      Citations: 37     Fields:    Translation:AnimalsCells
    33. Stonier SW, Ma LJ, Castillo EF, Schluns KS. Dendritic cells drive memory CD8 T-cell homeostasis via IL-15 transpresentation. Blood. 2008 Dec 01; 112(12):4546-54. PMID: 18812469.
      Citations: 45     Fields:    Translation:AnimalsCells
    34. Yang XO, Nurieva R, Martinez GJ, Kang HS, Chung Y, Pappu BP, Shah B, Chang SH, Schluns KS, Watowich SS, Feng XH, Jetten AM, Dong C. Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity. 2008 Jul 18; 29(1):44-56. PMID: 18585065.
      Citations: 469     Fields:    Translation:AnimalsCells
    35. Yang XO, Chang SH, Park H, Nurieva R, Shah B, Acero L, Wang YH, Schluns KS, Broaddus RR, Zhu Z, Dong C. Regulation of inflammatory responses by IL-17F. J Exp Med. 2008 May 12; 205(5):1063-75. PMID: 18411338.
      Citations: 285     Fields:    Translation:AnimalsCells
    36. Yang XO, Pappu BP, Nurieva R, Akimzhanov A, Kang HS, Chung Y, Ma L, Shah B, Panopoulos AD, Schluns KS, Watowich SS, Tian Q, Jetten AM, Dong C. T helper 17 lineage differentiation is programmed by orphan nuclear receptors ROR alpha and ROR gamma. Immunity. 2008 Jan; 28(1):29-39. PMID: 18164222.
      Citations: 592     Fields:    Translation:AnimalsCells
    37. Mercier GT, Nehete PN, Passeri MF, Nehete BN, Weaver EA, Templeton NS, Schluns K, Buchl SS, Sastry KJ, Barry MA. Oral immunization of rhesus macaques with adenoviral HIV vaccines using enteric-coated capsules. Vaccine. 2007 Dec 17; 25(52):8687-701. PMID: 18063450.
      Citations: 26     Fields:    Translation:AnimalsCells
    38. Nurieva R, Yang XO, Martinez G, Zhang Y, Panopoulos AD, Ma L, Schluns K, Tian Q, Watowich SS, Jetten AM, Dong C. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature. 2007 Jul 26; 448(7152):480-3. PMID: 17581589.
      Citations: 573     Fields:    Translation:AnimalsCells
    39. Stoklasek TA, Schluns KS, Lefrançois L. Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J Immunol. 2006 Nov 01; 177(9):6072-80. PMID: 17056533.
      Citations: 139     Fields:    Translation:AnimalsCells
    40. Schluns KS, Stoklasek T, Lefrançois L. The roles of interleukin-15 receptor alpha: trans-presentation, receptor component, or both? Int J Biochem Cell Biol. 2005 Aug; 37(8):1567-71. PMID: 15896666.
      Citations: 27     Fields:    Translation:HumansAnimals
    41. Sandau MM, Schluns KS, Lefrancois L, Jameson SC. Cutting edge: transpresentation of IL-15 by bone marrow-derived cells necessitates expression of IL-15 and IL-15R alpha by the same cells. J Immunol. 2004 Dec 01; 173(11):6537-41. PMID: 15557143.
      Citations: 65     Fields:    Translation:AnimalsCells
    42. Schluns KS, Nowak EC, Cabrera-Hernandez A, Puddington L, Lefrançois L, Aguila HL. Distinct cell types control lymphoid subset development by means of IL-15 and IL-15 receptor alpha expression. Proc Natl Acad Sci U S A. 2004 Apr 13; 101(15):5616-21. PMID: 15060278.
      Citations: 58     Fields:    Translation:AnimalsCells
    43. Schluns KS, Klonowski KD, Lefrançois L. Transregulation of memory CD8 T-cell proliferation by IL-15Ralpha+ bone marrow-derived cells. Blood. 2004 Feb 01; 103(3):988-94. PMID: 14512307.
      Citations: 56     Fields:    Translation:AnimalsCells
    44. Schluns KS, Lefrançois L. Cytokine control of memory T-cell development and survival. Nat Rev Immunol. 2003 Apr; 3(4):269-79. PMID: 12669018.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    45. D'Souza WN, Schluns KS, Masopust D, Lefrançois L. Essential role for IL-2 in the regulation of antiviral extralymphoid CD8 T cell responses. J Immunol. 2002 Jun 01; 168(11):5566-72. PMID: 12023352.
      Citations: 38     Fields:    Translation:AnimalsCells
    46. Schluns KS, Williams K, Ma A, Zheng XX, Lefrançois L. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol. 2002 May 15; 168(10):4827-31. PMID: 11994430.
      Citations: 173     Fields:    Translation:AnimalsCells
    47. Lefrançois L, Marzo AL, Masopust D, Schluns KS, Vezy V. Migration of primary and memory CD8 T cells. Adv Exp Med Biol. 2002; 512:141-6. PMID: 12405198.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Tsai SY, Schluns KS, Le PT, McNulty JA. TGF-beta1 and IL-6 expression in rat pineal gland is regulated by norepinephrine and interleukin-1beta. Histol Histopathol. 2001 10; 16(4):1135-41. PMID: 11642733.
      Citations: 7     Fields:    Translation:AnimalsCells
    49. Schluns KS, Kieper WC, Jameson SC, Lefrançois L. Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo. Nat Immunol. 2000 Nov; 1(5):426-32. PMID: 11062503.
      Citations: 536     Fields:    Translation:AnimalsCells
    50. Kim SK, Schluns KS, Lefrançois L. Induction and visualization of mucosal memory CD8 T cells following systemic virus infection. J Immunol. 1999 Oct 15; 163(8):4125-32. PMID: 10510347.
      Citations: 46     Fields:    Translation:AnimalsCells
    51. Schober SL, Kuo CT, Schluns KS, Lefrancois L, Leiden JM, Jameson SC. Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. J Immunol. 1999 Oct 01; 163(7):3662-7. PMID: 10490960.
      Citations: 47     Fields:    Translation:AnimalsCells
    52. Schluns KS, Cook JE, Le PT. TGF-beta differentially modulates epidermal growth factor-mediated increases in leukemia-inhibitory factor, IL-6, IL-1 alpha, and IL-1 beta in human thymic epithelial cells. J Immunol. 1997 Mar 15; 158(6):2704-12. PMID: 9058804.
      Citations: 7     Fields:    Translation:HumansCells
    53. Schluns KS, Grutkoski PS, Cook JE, Engelmann GL, Le PT. Human thymic epithelial cells produce TGF-beta 3 and express TGF-beta receptors. Int Immunol. 1995 Oct; 7(10):1681-90. PMID: 8562514.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    54. de Lanerolle P, Gorgas G, Li X, Schluns K. Myosin light chain phosphorylation does not increase during yeast phagocytosis by macrophages. J Biol Chem. 1993 Aug 15; 268(23):16883-6. PMID: 8349578.
      Citations: 5     Fields:    Translation:AnimalsCells
    55. Protecting the borders. Frontiers in Immunology. 6.
    56. Inflammatory signals regulate IL-15 in response to lymphodepletion. Journal of Immunology. 196:4544-4552.
    57. The transcription factor E74-like factor 4 suppresses differentiation of proliferating CD4+ T cells to the Th17 lineage. Journal of Immunology. 192:178-188.
    58. Neutrophils Regulate Humoral Autoimmunity by Restricting Interferon-γ Production via the Generation of Reactive Oxygen Species. Cell Reports. 12:1120-1132.
    59. Tgf-β1 modulates rag-2 expression in human thymocytes. FASEB Journal. 10.
    60. Soluble interleukin-15 complexes are generated in vivo by type i interferon dependent and independent pathways. PLoS One. 10.
    61. Human thymic epithelial cells induce anti-tcr-mediated apoptosis in an immature t cell line. FASEB Journal. 10.
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