MARCOS ROBERTO ESTECIO

TitleAssistant Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Heeke S, Gay CM, Estecio MR, Tran H, Morris BB, Zhang B, Tang X, Raso MG, Rocha P, Lai S, Arriola E, Hofman P, Hofman V, Kopparapu P, Lovly CM, Concannon K, De Sousa LG, Lewis WE, Kondo K, Hu X, Tanimoto A, Vokes NI, Nilsson MB, Stewart A, Jansen M, Horv?th I, Gaga M, Panagoulias V, Raviv Y, Frumkin D, Wasserstrom A, Shuali A, Schnabel CA, Xi Y, Diao L, Wang Q, Zhang J, Van Loo P, Wang J, Wistuba II, Byers LA, Heymach JV. Tumor- and circulating-free DNA methylation identifies clinically relevant small cell lung cancer subtypes. Cancer Cell. 2024 02 12; 42(2):225-237.e5. PMID: 38278149; PMCID: PMC10982990.
      Citations: 1     Fields:    Translation:HumansCells
    2. Figueroa M, Ma H, Alfayez M, Morales-Mantilla DE, Wang F, Lu Y, Estecio MR, King KY, Kleinerman E, Moghaddam SJ, Daver N, Andreeff M, Konopleva M, DiNardo C, Chandra J. Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Adv. 2023 11 14; 7(21):6624-6629. PMID: 37486624; PMCID: PMC10628807.
      Citations:    Fields:    Translation:Humans
    3. Chen Q, Liu B, Zeng Y, Hwang JW, Dai N, Corr?a IR, Estecio MR, Zhang X, Santos MA, Chen T, Cheng X. GSK-3484862 targets DNMT1 for degradation in cells. NAR Cancer. 2023 Jun; 5(2):zcad022. PMID: 37206360; PMCID: PMC10189803.
      Citations: 2     
    4. Darbaniyan F, Zheng H, Kanagal-Shamanna R, Lockyer P, Montalban-Bravo G, Estecio M, Lu Y, Soltysiak KA, Chien KS, Yang H, Sasaki K, Class C, Ganan-Gomez I, Do KA, Garcia-Manero G, Wei Y. Transcriptomic Signatures of Hypomethylating Agent Failure in Myelodysplastic Syndromes and Chronic Myelomonocytic Leukemia. Exp Hematol. 2022 11; 115:44-53. PMID: 36150563.
      Citations:    
    5. Soundararajan R, Viscuse P, Pilie P, Liu J, Logotheti S, Lorenzini D, Hoang A, Lu W, Soto LMS, Wistuba II, Xu M, Song X, Shepherd PDA, Navone NM, Tidwell RSS, Lozano G, Logothetis C, Zhang J, Long JP, Estecio MR, Tzelepi V, Aparicio AM, Laberiano Fern?ndez C. Genotype-to-Phenotype Associations in the Aggressive Variant Prostate Cancer Molecular Profile (AVPC-m) Components. Cancers (Basel). 2022 Jun 30; 14(13). PMID: 35805010; PMCID: PMC9265062.
      Citations:    
    6. Tu SM, Estecio MR, Lin SH, Zacharias NM. Stem Cell Theory of Cancer: Rude Awakening or Bad Dream from Cancer Dormancy? Cancers (Basel). 2022 Jan 27; 14(3). PMID: 35158923; PMCID: PMC8833524.
      Citations: 1     
    7. Johnson KC, Anderson KJ, Courtois ET, Gujar AD, Barthel FP, Varn FS, Luo D, Seignon M, Yi E, Kim H, Estecio MRH, Zhao D, Tang M, Navin NE, Maurya R, Ngan CY, Verburg N, de Witt Hamer PC, Bulsara K, Samuels ML, Das S, Robson P, Verhaak RGW. Single-cell multimodal glioma analyses identify epigenetic regulators of cellular plasticity and environmental stress response. Nat Genet. 2021 10; 53(10):1456-1468. PMID: 34594038; PMCID: PMC8570135.
      Citations: 9     Fields:    Translation:HumansCells
    8. Dejima H, Hu X, Chen R, Zhang J, Fujimoto J, Parra ER, Haymaker C, Hubert SM, Duose D, Solis LM, Su D, Fukuoka J, Tabata K, Pham HHN, Mcgranahan N, Zhang B, Ye J, Ying L, Little L, Gumbs C, Chow CW, Estecio MR, Godoy MCB, Antonoff MB, Sepesi B, Pass HI, Behrens C, Zhang J, Vaporciyan AA, Heymach JV, Scheet P, Lee JJ, Wu J, Futreal PA, Reuben A, Kadara H, Wistuba II, Zhang J. Immune evolution from preneoplasia to invasive lung adenocarcinomas and underlying molecular features. Nat Commun. 2021 05 11; 12(1):2722. PMID: 33976164; PMCID: PMC8113327.
      Citations: 22     Fields:    Translation:HumansCells
    9. Hu X, Estecio MR, Chen R, Reuben A, Wang L, Fujimoto J, Carrot-Zhang J, McGranahan N, Ying L, Fukuoka J, Chow CW, Pham HHN, Godoy MCB, Carter BW, Behrens C, Zhang J, Antonoff MB, Sepesi B, Lu Y, Pass HI, Kadara H, Scheet P, Vaporciyan AA, Heymach JV, Wistuba II, Lee JJ, Futreal PA, Su D, Issa JJ, Zhang J. Evolution of DNA methylome from precancerous lesions to invasive lung adenocarcinomas. Nat Commun. 2021 01 29; 12(1):687. PMID: 33514726; PMCID: PMC7846738.
      Citations: 8     Fields:    Translation:HumansCells
    10. Cortez MA, Masrorpour F, Ivan C, Zhang J, Younes AI, Lu Y, Estecio MR, Barsoumian HB, Menon H, da Silva Caetano M, Ramapriyan R, Schoenhals JE, Wang X, Skoulidis F, Wasley MD, Calin G, Hwu P, Welsh JW. Author Correction: Bone morphogenetic protein 7 promotes resistance to immunotherapy. Nat Commun. 2020 Oct 08; 11(1):5144. PMID: 33033261; PMCID: PMC7546718.
      Citations:    Fields:    
    11. Cortez MA, Masrorpour F, Ivan C, Zhang J, Younes AI, Lu Y, Estecio MR, Barsoumian HB, Menon H, Caetano MDS, Ramapriyan R, Schoenhals JE, Wang X, Skoulidis F, Wasley MD, Calin G, Hwu P, Welsh JW. Bone morphogenetic protein 7 promotes resistance to immunotherapy. Nat Commun. 2020 09 24; 11(1):4840. PMID: 32973129; PMCID: PMC7519103.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. DiNardo CD, Beird HC, Estecio M, Hardikar S, Takahashi K, Bannon SA, Borthakur G, Jabbour E, Gumbs C, Khoury JD, Routbort M, Gong T, Kondo K, Kantarjian H, Garcia-Manero G, Chen T, Futreal PA. Germline DNMT3A mutation in familial acute myeloid leukaemia. Epigenetics. 2021 05; 16(5):567-576. PMID: 32856987; PMCID: PMC8078744.
      Citations: 3     Fields:    Translation:HumansCells
    13. Vantaku V, Amara CS, Piyarathna DWB, Donepudi SR, Ambati CR, Putluri V, Tang W, Rajapakshe K, Estecio MR, Terris MK, Castro PD, Ittmann MM, Williams SB, Lerner SP, Sreekumar A, Bollag R, Coarfa C, Kornberg MD, Lotan Y, Ambs S, Putluri N. DNA methylation patterns in bladder tumors of African American patients point to distinct alterations in xenobiotic metabolism. Carcinogenesis. 2019 11 25; 40(11):1332-1340. PMID: 31284295; PMCID: PMC6875901.
      Citations: 3     Fields:    Translation:HumansCells
    14. Saha D, Gowher H, Zhao H, Veland N, Lu Y, Hardikar S, Gaddis S, Zeng Y, Liu B, Estecio MR, Takata Y, Lin K, Tomida MW, Shen J, Chen T. DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells. Nucleic Acids Res. 2019 01 10; 47(1):152-167. PMID: 30321403; PMCID: PMC6326784.
      Citations: 28     Fields:    Translation:AnimalsCells
    15. Gu T, Lin X, Cullen SM, Luo M, Jeong M, Estecio M, Shen J, Hardikar S, Sun D, Su J, Rux D, Guzman A, Lee M, Qi LS, Chen JJ, Kyba M, Huang Y, Chen T, Li W, Goodell MA. DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells. Genome Biol. 2018 07 12; 19(1):88. PMID: 30001199; PMCID: PMC6042404.
      Citations: 54     Fields:    Translation:AnimalsCells
    16. Shah MY, Ferracin M, Pileczki V, Chen B, Redis R, Fabris L, Zhang X, Ivan C, Shimizu M, Rodriguez-Aguayo C, Dragomir M, Van Roosbroeck K, Almeida MI, Ciccone M, Nedelcu D, Cortez MA, Manshouri T, Calin S, Muftuoglu M, Banerjee PP, Badiwi MH, Parker-Thornburg J, Multani A, Welsh JW, Estecio MR, Ling H, Tomuleasa C, Dima D, Yang H, Alvarez H, You MJ, Radovich M, Shpall E, Fabbri M, Rezvani K, Girnita L, Berindan-Neagoe I, Maitra A, Verstovsek S, Fodde R, Bueso-Ramos C, Gagea M, Manero GG, Calin GA. Cancer-associated rs6983267 SNP and its accompanying long noncoding RNA CCAT2 induce myeloid malignancies via unique SNP-specific RNA mutations. Genome Res. 2018 04; 28(4):432-447. PMID: 29567676; PMCID: PMC5880235.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    17. Rossi EL, Dunlap SM, Bowers LW, Khatib SA, Doerstling SS, Smith LA, Ford NA, Holley D, Brown PH, Estecio MR, Kusewitt DF, deGraffenried LA, Bultman SJ, Hursting SD. Energy Balance Modulation Impacts Epigenetic Reprogramming, ERa and ER? Expression, and Mammary Tumor Development in MMTV-neu Transgenic Mice. Cancer Res. 2017 05 01; 77(9):2500-2511. PMID: 28373182; PMCID: PMC5964334.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    18. Quek K, Li J, Estecio M, Zhang J, Fujimoto J, Roarty E, Little L, Chow CW, Song X, Behrens C, Chen T, William WN, Swisher S, Heymach J, Wistuba I, Zhang J, Futreal A, Zhang J. DNA methylation intratumor heterogeneity in localized lung adenocarcinomas. Oncotarget. 2017 Mar 28; 8(13):21994-22002. PMID: 28423542; PMCID: PMC5400640.
      Citations: 17     Fields:    Translation:HumansCells
    19. Long Y, Tsai WB, Chang JT, Estecio M, Wangpaichitr M, Savaraj N, Feun LG, Chen HH, Kuo MT. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1a, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 2016 Dec 13; 7(50):82658-82670. PMID: 27765932; PMCID: PMC5347722.
      Citations: 21     Fields:    Translation:HumansCells
    20. Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In?Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 06 28; 16(1):133-147. PMID: 27320920.
      Citations: 55     Fields:    Translation:HumansAnimalsCells
    21. Rossi EL, de Angel RE, Bowers LW, Khatib SA, Smith LA, Van Buren E, Bhardwaj P, Giri D, Estecio MR, Troester MA, Hair BY, Kirk EL, Gong T, Shen J, Dannenberg AJ, Hursting SD. Obesity-Associated Alterations in Inflammation, Epigenetics, and Mammary Tumor Growth Persist in Formerly Obese Mice. Cancer Prev Res (Phila). 2016 05; 9(5):339-48. PMID: 26869351; PMCID: PMC4854773.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    22. Qin T, Si J, Wang X, Gharibyan V, Ahmed S, Hu X, Jin C, Lu Y, Shu J, Estecio MR, Jelinek J, Issa JJ, Raynal NJ. Epigenetic synergy between decitabine and platinum derivatives. Clin Epigenetics. 2015; 7:97. PMID: 26366234; PMCID: PMC4567801.
      Citations: 15     Fields:    
    23. Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estecio MR, Sahin AA, Aldaz CM. A Molecular Portrait of High-Grade Ductal Carcinoma In Situ. Cancer Res. 2015 Sep 15; 75(18):3980-90. PMID: 26249178; PMCID: PMC4768486.
      Citations: 62     Fields:    Translation:HumansCells
    24. Yang H, Maddipoti S, Quesada A, Bohannan Z, Cabrero Calvo M, Colla S, Wei Y, Estecio M, Wierda W, Bueso-Ramos C, Garcia-Manero G. Analysis of class I and II histone deacetylase gene expression in human leukemia. Leuk Lymphoma. 2015; 56(12):3426-33. PMID: 25944469; PMCID: PMC4762655.
      Citations: 9     Fields:    Translation:HumansCells
    25. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol. 2015 Sep; 36(10):8147-58. PMID: 25990457.
      Citations: 4     Fields:    Translation:HumansCells
    26. Yamazaki J, Jelinek J, Lu Y, Cesaroni M, Madzo J, Neumann F, He R, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Kantarjian HM, Liang S, Estecio MR, Godley LA, Issa JP. TET2 Mutations Affect Non-CpG Island DNA Methylation at Enhancers and Transcription Factor-Binding Sites in Chronic Myelomonocytic Leukemia. Cancer Res. 2015 Jul 15; 75(14):2833-43. PMID: 25972343; PMCID: PMC4506197.
      Citations: 42     Fields:    Translation:HumansCellsCTClinical Trials
    27. Colla S, Ong DS, Ogoti Y, Marchesini M, Mistry NA, Clise-Dwyer K, Ang SA, Storti P, Viale A, Giuliani N, Ruisaard K, Ganan Gomez I, Bristow CA, Estecio M, Weksberg DC, Ho YW, Hu B, Genovese G, Pettazzoni P, Multani AS, Jiang S, Hua S, Ryan MC, Carugo A, Nezi L, Wei Y, Yang H, D'Anca M, Zhang L, Gaddis S, Gong T, Horner JW, Heffernan TP, Jones P, Cooper LJ, Liang H, Kantarjian H, Wang YA, Chin L, Bueso-Ramos C, Garcia-Manero G, DePinho RA. Telomere dysfunction drives aberrant hematopoietic differentiation and myelodysplastic syndrome. Cancer Cell. 2015 May 11; 27(5):644-57. PMID: 25965571; PMCID: PMC4596059.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    28. Maddipoti S, Bueso-Ramos C, DiNardo CD, Yang H, Wei Y, Kondo K, Fang Z, Stevenson W, Chang KS, Pierce SA, Bohannan Z, Borthakur G, Kantarjian H, Garcia-Manero G, Est?cio MR. RUNX3 promoter hypermethylation is frequent in leukaemia cell lines and associated with acute myeloid leukaemia inv(16) subtype. Br J Haematol. 2015 May; 169(3):344-51. PMID: 25612675; PMCID: PMC4762375.
      Citations: 13     Fields:    Translation:HumansCells
    29. Xu Y, Zheng X, Yuan Y, Estecio MR, Issa JP, Qiu P, Ji Y, Liang S. BM-SNP: A Bayesian Model for SNP Calling Using High Throughput Sequencing Data. IEEE/ACM Trans Comput Biol Bioinform. 2014 Nov-Dec; 11(6):1038-44. PMID: 26357041.
      Citations:    Fields:    Translation:HumansCells
    30. Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res. 2014 Jun; 42(11):6956-71. PMID: 24875481; PMCID: PMC4066785.
      Citations: 68     Fields:    Translation:HumansCells
    31. Maegawa S, Gough SM, Watanabe-Okochi N, Lu Y, Zhang N, Castoro RJ, Estecio MR, Jelinek J, Liang S, Kitamura T, Aplan PD, Issa JP. Age-related epigenetic drift in the pathogenesis of MDS and AML. Genome Res. 2014 Apr; 24(4):580-91. PMID: 24414704; PMCID: PMC3975058.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    32. Tahara T, Yamamoto E, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, An B, Shureiqi I, Toyota M, Kondo Y, Issa JP, Est?cio MR. Fusobacterium in colonic flora and molecular features of colorectal carcinoma. Cancer Res. 2014 Mar 01; 74(5):1311-8. PMID: 24385213; PMCID: PMC4396185.
      Citations: 189     Fields:    Translation:HumansCells
    33. Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estecio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol. 2013 Dec 24; 14(12):R144. PMID: 24367927; PMCID: PMC4053791.
      Citations: 38     Fields:    Translation:HumansCells
    34. Tahara T, Yamamoto E, Madireddi P, Suzuki H, Maruyama R, Chung W, Garriga J, Jelinek J, Yamano HO, Sugai T, Kondo Y, Toyota M, Issa JP, Est?cio MR. Colorectal carcinomas with CpG island methylator phenotype 1 frequently contain mutations in chromatin regulators. Gastroenterology. 2014 Feb; 146(2):530-38.e5. PMID: 24211491; PMCID: PMC3918446.
      Citations: 41     Fields:    Translation:HumansCells
    35. Tahara T, Maegawa S, Chung W, Garriga J, Jelinek J, Shibata T, Hirata I, Arisawa T, Issa JP, Est?cio MR. Examination of whole blood DNA methylation as a potential risk marker for gastric cancer. Cancer Prev Res (Phila). 2013 Oct; 6(10):1093-100. PMID: 23943784; PMCID: PMC4337829.
      Citations: 15     Fields:    Translation:HumansCells
    36. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA, Gaf? R, Le Marchand L. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep; 23(9):1446-61. PMID: 23796952; PMCID: PMC3759721.
      Citations: 314     Fields:    Translation:HumansAnimalsCells
    37. Yamazaki J, Estecio MR, Lu Y, Long H, Malouf GG, Graber D, Huo Y, Ramagli L, Liang S, Kornblau SM, Jelinek J, Issa JP. The epigenome of AML stem and progenitor cells. Epigenetics. 2013 Jan; 8(1):92-104. PMID: 23249680; PMCID: PMC3549884.
      Citations: 21     Fields:    Translation:HumansCells
    38. Xu Y, Zheng X, Yuan Y, Estecio MR, Issa JP, Ji Y, Liang S. A Bayesian Model for SNP Discovery Based on Next-Generation Sequencing Data. IEEE Int Workshop Genomic Signal Process Stat. 2012 Dec; 2012:42-45. PMID: 26726304; PMCID: PMC4697941.
      Citations:    
    39. Jelinek J, Liang S, Lu Y, He R, Ramagli LS, Shpall EJ, Estecio MR, Issa JP. Conserved DNA methylation patterns in healthy blood cells and extensive changes in leukemia measured by a new quantitative technique. Epigenetics. 2012 Dec 01; 7(12):1368-78. PMID: 23075513; PMCID: PMC3528692.
      Citations: 35     Fields:    Translation:HumansCells
    40. Gallegos J, Dekmezian M, Lu Y, Liang S, Issa JP, Est?cio MR. SINE retrotransposons cause epigenetic reprogramming of adjacent gene promoters. Mol Cancer Res. 2012 Oct; 10(10):1332-42. PMID: 22952045; PMCID: PMC3475755.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    41. Zhang Y, Shu J, Si J, Shen L, Estecio MR, Issa JP. Repetitive elements and enforced transcriptional repression co-operate to enhance DNA methylation spreading into a promoter CpG-island. Nucleic Acids Res. 2012 Aug; 40(15):7257-68. PMID: 22600741; PMCID: PMC3424568.
      Citations: 12     Fields:    Translation:HumansCells
    42. Yamazaki J, Taby R, Vasanthakumar A, Macrae T, Ostler KR, Shen L, Kantarjian HM, Estecio MR, Jelinek J, Godley LA, Issa JP. Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia. Epigenetics. 2012 Feb; 7(2):201-7. PMID: 22395470; PMCID: PMC3335912.
      Citations: 56     Fields:    Translation:HumansCells
    43. Si J, Taby RF, Gharibyan V, Ahmed S, Jelinek J, Issa JP, Raynal NJ, Est?cio MR. DNA methylation does not stably lock gene expression but instead serves as a molecular mark for gene silencing memory. Cancer Res. 2012 Mar 01; 72(5):1170-81. PMID: 22219169; PMCID: PMC3294136.
      Citations: 64     Fields:    Translation:HumansCells
    44. Konishi K, Watanabe Y, Shen L, Guo Y, Castoro RJ, Kondo K, Chung W, Ahmed S, Jelinek J, Boumber YA, Estecio MR, Maegawa S, Kondo Y, Itoh F, Imawari M, Hamilton SR, Issa JP. DNA methylation profiles of primary colorectal carcinoma and matched liver metastasis. PLoS One. 2011; 6(11):e27889. PMID: 22132162; PMCID: PMC3221680.
      Citations: 15     Fields:    Translation:HumansCells
    45. Watanabe Y, Castoro RJ, Kim HS, North B, Oikawa R, Hiraishi T, Ahmed SS, Chung W, Cho MY, Toyota M, Itoh F, Estecio MR, Shen L, Jelinek J, Issa JP. Frequent alteration of MLL3 frameshift mutations in microsatellite deficient colorectal cancer. PLoS One. 2011; 6(8):e23320. PMID: 21853109; PMCID: PMC3154922.
      Citations: 41     Fields:    Translation:HumansCells
    46. Jelinek J, Gharibyan V, Estecio MR, Kondo K, He R, Chung W, Lu Y, Zhang N, Liang S, Kantarjian HM, Cortes JE, Issa JP. Aberrant DNA methylation is associated with disease progression, resistance to imatinib and shortened survival in chronic myelogenous leukemia. PLoS One. 2011; 6(7):e22110. PMID: 21760961; PMCID: PMC3132778.
      Citations: 52     Fields:    Translation:HumansCells
    47. Issa JP, Est?cio MR. Dissecting DNA hypermethylation in cancer. FEBS Lett. 2011 Jul 07; 585(13):2078-86. PMID: 21146531; PMCID: PMC3378045.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    48. Gallegos J, Castoro RJ, Chung W, Maegawa S, Oki Y, Kondo Y, Jelinek J, Shen L, Hartung H, Aplan PD, Czerniak BA, Liang S, Issa JP, Est?cio MR, Vallot C. Genome architecture marked by retrotransposons modulates predisposition to DNA methylation in cancer. Genome Res. 2010 Oct; 20(10):1369-82. PMID: 20716667; PMCID: PMC2945186.
      Citations: 49     Fields:    Translation:HumansCells
    49. Issa JP, Est?cio MR. Tackling the methylome: recent methodological advances in genome-wide methylation profiling. Genome Med. 2009 Nov 16; 1(11):106. PMID: 19930617; PMCID: PMC2808741.
      Citations: 8     Fields:    
    50. Tellez CS, Shen L, Jelinek J, Gershenwald JE, Issa JP, Est?cio MR. CpG island methylation profiling in human melanoma cell lines. Melanoma Res. 2009 Jun; 19(3):146-55. PMID: 19441164.
      Citations: 45     Fields:    Translation:HumansCells
    51. Watanabe Y, Kim HS, Castoro RJ, Chung W, Estecio MR, Kondo K, Guo Y, Ahmed SS, Toyota M, Itoh F, Suk KT, Cho MY, Shen L, Jelinek J, Issa JP. Sensitive and specific detection of early gastric cancer with DNA methylation analysis of gastric washes. Gastroenterology. 2009 Jun; 136(7):2149-58. PMID: 19375421; PMCID: PMC2722957.
      Citations: 52     Fields:    Translation:HumansCells
    52. Liang S, Lu Y, Jelinek J, Estecio M, Li H, Issa JP. Analysis of epigenetic modifications by next generation sequencing. Annu Int Conf IEEE Eng Med Biol Soc. 2009; 2009:6730. PMID: 19963934.
      Citations: 2     Fields:    Translation:AnimalsCells
    53. Boumber YA, Kondo Y, Chen X, Shen L, Guo Y, Tellez C, Ahmed S, Issa JP, Est?cio MR. An Sp1/Sp3 binding polymorphism confers methylation protection. PLoS Genet. 2008 Aug 22; 4(8):e1000162. PMID: 18725933; PMCID: PMC2515197.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    54. Kroeger H, Jelinek J, He R, Kondo K, Chung W, Zhang L, Shen L, Kantarjian HM, Bueso-Ramos CE, Issa JP, Est?cio MR. Aberrant CpG island methylation in acute myeloid leukemia is accentuated at relapse. Blood. 2008 Aug 15; 112(4):1366-73. PMID: 18523155; PMCID: PMC2515110.
      Citations: 61     Fields:    Translation:HumansCells
    55. Yan PS, Huang TH, Issa JP, Est?cio MR. Methylated CpG Island Amplification and Microarray (MCAM) for High-Throughput Analysis of DNA Methylation. CSH Protoc. 2008 Mar 01; 2008:pdb.prot4974. PMID: 21356790.
      Citations: 4     
    56. Yan PS, Ibrahim AE, Tellez CS, Shen L, Huang TH, Issa JP, Est?cio MR. High-throughput methylation profiling by MCA coupled to CpG island microarray. Genome Res. 2007 Oct; 17(10):1529-36. PMID: 17785535; PMCID: PMC1987348.
      Citations: 69     Fields:    Translation:HumansCells
    57. Choi IS, Estecio MR, Nagano Y, Kim DH, White JA, Yao JC, Issa JP, Rashid A. Hypomethylation of LINE-1 and Alu in well-differentiated neuroendocrine tumors (pancreatic endocrine tumors and carcinoid tumors). Mod Pathol. 2007 Jul; 20(7):802-10. PMID: 17483816.
      Citations: 58     Fields:    Translation:HumansCells
    58. Gharibyan V, Shen L, Ibrahim AE, Doshi K, He R, Jelinek J, Yang AS, Yan PS, Huang TH, Tajara EH, Issa JP, Est?cio MR. LINE-1 hypomethylation in cancer is highly variable and inversely correlated with microsatellite instability. PLoS One. 2007 May 02; 2(5):e399. PMID: 17476321; PMCID: PMC1851990.
      Citations: 131     Fields:    Translation:HumansCells
    59. Montero AJ, Mao L, Youssef EM, Estecio M, Shen L, Issa JP, D?az-Montero CM. Epigenetic inactivation of EGFR by CpG island hypermethylation in cancer. Cancer Biol Ther. 2006 Nov; 5(11):1494-501. PMID: 17369752.
      Citations: 29     Fields:    Translation:HumansCells
    60. Youssef EM, Rahal P, Fukuyama EE, Maniglia JV, Goloni-Bertollo EM, Issa JP, Tajara EH, Est?cio MR, G?is-Filho JF. LHX6 is a sensitive methylation marker in head and neck carcinomas. Oncogene. 2006 Aug 17; 25(36):5018-26. PMID: 16732332.
      Citations: 23     Fields:    Translation:HumansCells
    61. Yang AS, Doshi KD, Choi SW, Mason JB, Mannari RK, Gharybian V, Luna R, Rashid A, Shen L, Estecio MR, Kantarjian HM, Garcia-Manero G, Issa JP. DNA methylation changes after 5-aza-2'-deoxycytidine therapy in patients with leukemia. Cancer Res. 2006 May 15; 66(10):5495-503. PMID: 16707479.
      Citations: 114     Fields:    Translation:HumansCells
    62. Yang AS, Doshi K, Kondo Y, Tajara EH, Issa JP, Est?cio MR. A simple method for estimating global DNA methylation using bisulfite PCR of repetitive DNA elements. Nucleic Acids Res. 2004 Feb 18; 32(3):e38. PMID: 14973332; PMCID: PMC373427.
      Citations: 474     Fields:    Translation:HumansCells
    63. Youssef EM, Estecio MR, Issa JP. Methylation and regulation of expression of different retinoic acid receptor beta isoforms in human colon cancer. Cancer Biol Ther. 2004 Jan; 3(1):82-6. PMID: 14726683.
      Citations: 13     Fields:    Translation:HumansCells
    64. Yang AS, Estecio MR, Garcia-Manero G, Kantarjian HM, Issa JP. Comment on "Chromosomal instability and tumors promoted by DNA hypomethylation" and "Induction of tumors in nice by genomic hypomethylation". Science. 2003 Nov 14; 302(5648):1153; author reply 1153. PMID: 14615517.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    65. Mancini UM, Fukuyama EE, Valentim PJ, Cury PM, Bertollo EM, Tajara EH, Est?cio MR, G?is JF. The chromosome 5q21 band minisatellite and head and neck cancer. Cancer Genet Cytogenet. 2003 Nov; 147(1):87-8. PMID: 14580779.
      Citations:    Fields:    Translation:HumansCells
    66. Silva AE, Estecio MR. [Chromosome abnormalities caused by computer video display monitors' radiation]. Rev Saude Publica. 2002 Jun; 36(3):330-6. PMID: 12131973.
      Citations: 1     Fields:    Translation:HumansPHPublic Health
    67. Analysis of class i and II histone deacetylase gene expression in human leukemia. Leukemia and Lymphoma. 56:3426-3433.
    68. Obesity-associated alterations in inflammation, epigenetics, and mammary tumor growth persist in formerly obese mice. Cancer Prevention Research. 9:339-348.
    69. Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas. Epigenetics. 1-10.
    70. Analysis of epigenetic modifications by next generation sequencing. 6730.
    71. Epigenetic synergy between decitabine and platinum derivatives. Clinical Epigenetics. 7.
    72. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports. 16:133-147.
    73. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumor Biology.
    74. CSA-RRBS. 105-110.
    75. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 7:82658-82670.
    76. Epigenetic mechanisms of induced pluripotency. Wspolczesna Onkologia. 1A:A30-A38.
    77. Relevância da genética na etiologia do autismo. Jornal Brasileiro de Psiquiatria. 49:239-246.
    78. A Bayesian model for SNP discovery based on next-generation sequencing data. 42-45.
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