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PETRA DEN HOLLANDER

TitleInstructor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. den Hollander P, Maddela JJ, Mani SA. Spatial and Temporal Relationship between Epithelial-Mesenchymal Transition (EMT) and Stem Cells in Cancer. Clin Chem. 2024 01 04; 70(1):190-205. PMID: 38175600.
      Citations:    Fields:    
    2. Kuburich NA, den Hollander P, Castaneda M, Pietil? M, Tang X, Batra H, Mart?nez-Pe?a F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, Rosolen MJ, Sabapathy T, Kumar D, Giancotti FG, Lairson LL, Raso MG, Soundararajan R, Mani SA. Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas. Cell Rep. 2023 12 26; 42(12):113470. PMID: 37979166.
      Citations: 1     Fields:    Translation:HumansCells
    3. Kuburich NA, Sabapathy T, Demestichas BR, Maddela JJ, den Hollander P, Mani SA. Proactive and reactive roles of TGF-? in cancer. Semin Cancer Biol. 2023 10; 95:120-139. PMID: 37572731; PMCID: PMC10530624.
      Citations: 1     Fields:    Translation:HumansCells
    4. Friedlaender A, Addeo A, Miranda-Morales E, den Hollander P, O Sintim H, Wu J, Mani SA, Subbiah V. RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives. Pharmacol Ther. 2023 02; 242:108344. PMID: 36632846; PMCID: PMC10141525.
      Citations: 3     Fields:    Translation:Humans
    5. Castaneda M, den Hollander P, Kuburich NA, Rosen JM, Mani SA. Mechanisms of cancer metastasis. Semin Cancer Biol. 2022 Dec; 87:17-31. PMID: 36354098.
      Citations: 8     Fields:    Translation:Humans
    6. Kudaravalli S, den Hollander P, Mani SA. Role of p38 MAP kinase in cancer stem cells and metastasis. Oncogene. 2022 06; 41(23):3177-3185. PMID: 35501462; PMCID: PMC9166676.
      Citations: 1     Fields:    Translation:HumansCells
    7. Visal TH, den Hollander P, Cristofanilli M, Mani SA. Circulating tumour cells in the -omics era: how far are we from achieving the 'singularity'? Br J Cancer. 2022 07; 127(2):173-184. PMID: 35273384; PMCID: PMC9296521.
      Citations: 2     Fields:    Translation:HumansCells
    8. Deshmukh AP, den Hollander P, Kuburich NA, Vasaikar S, Joseph R, Mani SA. Enrichment of Cancer Stem Cells in a Tumorsphere Assay. Methods Mol Biol. 2022; 2429:501-507. PMID: 35507184.
      Citations:    Fields:    Translation:HumansCells
    9. Kuburich NA, den Hollander P, Deshmukh AP, Vasaikar S, Joseph R, Wicha MS, Mani SA. In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay. Methods Mol Biol. 2022; 2429:509-513. PMID: 35507185.
      Citations:    Fields:    Translation:HumansCells
    10. den Hollander P, Joseph R, Vasaikar S, Kuburich NA, Deshmukh AP, Mani SA. Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells. Methods Mol Biol. 2022; 2429:547-554. PMID: 35507188.
      Citations:    Fields:    Translation:HumansCells
    11. Kuburich NA, den Hollander P, Pietz JT, Mani SA. Vimentin and cytokeratin: Good alone, bad together. Semin Cancer Biol. 2022 11; 86(Pt 3):816-826. PMID: 34953942; PMCID: PMC9213573.
      Citations:    Fields:    
    12. Bushnell GG, Deshmukh AP, den Hollander P, Luo M, Soundararajan R, Jia D, Levine H, Mani SA, Wicha MS. Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge. NPJ Breast Cancer. 2021 May 28; 7(1):66. PMID: 34050189; PMCID: PMC8163741.
      Citations: 6     
    13. Deshmukh AP, Vasaikar SV, Tomczak K, Tripathi S, den Hollander P, Arslan E, Chakraborty P, Soundararajan R, Jolly MK, Rai K, Levine H, Mani SA. Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). PMID: 33941680; PMCID: PMC8126782.
      Citations: 23     Fields:    Translation:HumansCells
    14. Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 07; 125(2):176-189. PMID: 33795809; PMCID: PMC8292398.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    15. Vasaikar SV, Deshmukh AP, den Hollander P, Addanki S, Kuburich NA, Kudaravalli S, Joseph R, Chang JT, Soundararajan R, Mani SA. EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures. Br J Cancer. 2021 01; 124(1):259-269. PMID: 33299129; PMCID: PMC7782839.
      Citations: 27     Fields:    Translation:HumansCells
    16. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199; PMCID: PMC10473373.
      Citations: 2     Fields:    
    17. Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z, Chang JT, Vasaikar S, Soundararajan R, Sreekumar A, Mani SA, Ramirez-Pe?a E, Mat?s JM, M?rquez J. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression. Cancers (Basel). 2019 Oct 22; 11(10). PMID: 31652551; PMCID: PMC6826439.
      Citations: 15     
    18. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 04; 39(15):3089-3101. PMID: 31308490; PMCID: PMC6960374.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    19. Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA, Pietila M. GSK3? regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 03 07; 21(1):37. PMID: 30845991; PMCID: PMC6407242.
      Citations: 34     Fields:    Translation:HumansCells
    20. Jia D, Jolly MK, Tripathi SC, Den Hollander P, Huang B, Lu M, Celiktas M, Ben-Jacob E, Hanash SM, Mani SA, Levine H, Ramirez-Pe?a E, Onuchic JN. Distinguishing mechanisms underlying EMT tristability. Cancer Converg. 2017; 1(1):2. PMID: 29623961; PMCID: PMC5876698.
      Citations: 35     
    21. Mazumdar A, Poage GM, Shepherd J, Tsimelzon A, Hartman ZC, Den Hollander P, Hill J, Zhang Y, Chang J, Hilsenbeck SG, Fuqua S, Kent Osborne C, Mills GB, Brown PH. Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. Breast Cancer Res Treat. 2016 08; 158(3):441-54. PMID: 27393618; PMCID: PMC4963453.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    22. den Hollander P, Rawls K, Tsimelzon A, Shepherd J, Mazumdar A, Hill J, Fuqua SA, Chang JC, Osborne CK, Hilsenbeck SG, Mills GB, Brown PH. Phosphatase PTP4A3 Promotes Triple-Negative Breast Cancer Growth and Predicts Poor Patient Survival. Cancer Res. 2016 04 01; 76(7):1942-53. PMID: 26921331; PMCID: PMC4873402.
      Citations: 39     Fields:    Translation:HumansCells
    23. den Hollander P, Savage MI, Brown PH. Targeted therapy for breast cancer prevention. Front Oncol. 2013 Sep 23; 3:250. PMID: 24069582; PMCID: PMC3780469.
      Citations: 56     
    24. Hartman ZC, Poage GM, den Hollander P, Tsimelzon A, Hill J, Panupinthu N, Zhang Y, Mazumdar A, Hilsenbeck SG, Mills GB, Brown PH. Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. Cancer Res. 2013 Jun 01; 73(11):3470-80. PMID: 23633491; PMCID: PMC3853111.
      Citations: 198     Fields:    Translation:HumansAnimalsCells
    25. Hampton OA, Koriabine M, Miller CA, Coarfa C, Li J, Den Hollander P, Schoenherr C, Carbone L, Nefedov M, Ten Hallers BF, Lee AV, De Jong PJ, Milosavljevic A. Long-range massively parallel mate pair sequencing detects distinct mutations and similar patterns of structural mutability in two breast cancer cell lines. Cancer Genet. 2011 Aug; 204(8):447-57. PMID: 21962895; PMCID: PMC3185296.
      Citations: 13     Fields:    Translation:HumansCells
    26. Hampton OA, Den Hollander P, Miller CA, Delgado DA, Li J, Coarfa C, Harris RA, Richards S, Scherer SE, Muzny DM, Gibbs RA, Lee AV, Milosavljevic A. A sequence-level map of chromosomal breakpoints in the MCF-7 breast cancer cell line yields insights into the evolution of a cancer genome. Genome Res. 2009 Feb; 19(2):167-77. PMID: 19056696; PMCID: PMC2652200.
      Citations: 72     Fields:    Translation:HumansCells
    27. Fontenot DR, den Hollander P, Vela EM, Newman R, Sastry JK, Kumar R. Dynein light chain 1 peptide inhibits human immunodeficiency virus infection in eukaryotic cells. Biochem Biophys Res Commun. 2007 Nov 30; 363(4):901-7. PMID: 17919453.
      Citations: 6     Fields:    Translation:HumansCells
    28. den Hollander P, Rayala SK, Coverley D, Kumar R. Ciz1, a Novel DNA-binding coactivator of the estrogen receptor alpha, confers hypersensitivity to estrogen action. Cancer Res. 2006 Nov 15; 66(22):11021-9. PMID: 17108141.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    29. den Hollander P, Kumar R. Dynein light chain 1 contributes to cell cycle progression by increasing cyclin-dependent kinase 2 activity in estrogen-stimulated cells. Cancer Res. 2006 Jun 01; 66(11):5941-9. PMID: 16740735.
      Citations: 17     Fields:    Translation:HumansCells
    30. Rayala SK, den Hollander P, Manavathi B, Talukder AH, Song C, Peng S, Barnekow A, Kremerskothen J, Kumar R. Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells. J Biol Chem. 2006 Jul 14; 281(28):19092-9. PMID: 16684779.
      Citations: 37     Fields:    Translation:HumansCells
    31. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6670-5. PMID: 16617102; PMCID: PMC1458939.
      Citations: 61     Fields:    Translation:HumansCells
    32. Rayala SK, Hollander Pd, Balasenthil S, Molli PR, Bean AJ, Vadlamudi RK, Wang RA, Kumar R. Hepatocyte growth factor-regulated tyrosine kinase substrate (HRS) interacts with PELP1 and activates MAPK. J Biol Chem. 2006 Feb 17; 281(7):4395-403. PMID: 16352611.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    33. Rayala SK, den Hollander P, Balasenthil S, Yang Z, Broaddus RR, Kumar R. Functional regulation of oestrogen receptor pathway by the dynein light chain 1. EMBO Rep. 2005 Jun; 6(6):538-44. PMID: 15891768; PMCID: PMC1369089.
      Citations: 28     Fields:    Translation:HumansCells
    34. Overexpressed DLC1 as target for breast cancer cell shape and survival. Cancer Biol Ther. 2004 Jul; 3(7):587-8. PMID: 15754445.
      Citations:    Fields:    Translation:HumansCells
    35. Vadlamudi RK, Bagheri-Yarmand R, Yang Z, Balasenthil S, Nguyen D, Sahin AA, den Hollander P, Kumar R. Dynein light chain 1, a p21-activated kinase 1-interacting substrate, promotes cancerous phenotypes. Cancer Cell. 2004 Jun; 5(6):575-85. PMID: 15193260.
      Citations: 78     Fields:    Translation:HumansCells
    36. Izzo JG, Papadimitrakopoulou VA, Liu DD, den Hollander PL, Babenko IM, Keck J, El-Naggar AK, Shin DM, Lee JJ, Hong WK, Hittelman WN. Cyclin D1 genotype, response to biochemoprevention, and progression rate to upper aerodigestive tract cancer. J Natl Cancer Inst. 2003 Feb 05; 95(3):198-205. PMID: 12569141.
      Citations: 21     Fields:    Translation:HumansCTClinical Trials
    37. Targeted therapy for breast cancer prevention. Frontiers in Oncology. 3 SEP.
    38. Erratum to Dynein Light Chain 1, a p21-Activated Kinase 1-Interacting Substrate, Promotes Cancerous Phenotypes [Cancer Cell, 5 (2004) 575-585]. Cancer Cell. 23:421-422.
    39. Phosphatase PTP4A3 promotes triple-negative breast cancer growth and predicts poor patient survival. Cancer Research. 76:1942-1953.
    40. Erratum. EMBO Reports. 6:1101.
    41. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 110:4147-4148.
    42. Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. Breast Cancer Research and Treatment. 1-14.
    43. Erratum. Cancer Cell. 6:101.
    44. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
    45. Advances in targeted therapy for the prevention of breast cancer. Breast Diseases. 24:309-314.
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