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HELENE PELICANO

TitleInstructor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen DL, Ju HQ, Lu YX, Chen LZ, Zeng ZL, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Xu DZ, Zhou ZW, Pelicano H, Huang P, Xie D, Wang FH, Li YH, Xu RH. Correction to: Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res. 2021 Jun 24; 40(1):208. PMID: 34167550; PMCID: PMC8223325.
      Citations:    Fields:    
    2. Ding L, Zhang W, Yang L, Pelicano H, Zhou K, Yin R, Huang R, Zeng J. Targeting the autophagy in bone marrow stromal cells overcomes resistance to vorinostat in chronic lymphocytic leukemia. Onco Targets Ther. 2018; 11:5151-5170. PMID: 30210236; PMCID: PMC6114474.
      Citations: 9     
    3. Liu J, Chen G, Liu Z, Liu S, Cai Z, You P, Ke Y, Lai L, Huang Y, Gao H, Zhao L, Pelicano H, Huang P, McKeehan WL, Wu CL, Wang C, Zhong W, Wang F. Aberrant FGFR Tyrosine Kinase Signaling Enhances the Warburg Effect by Reprogramming LDH Isoform Expression and Activity in Prostate Cancer. Cancer Res. 2018 08 15; 78(16):4459-4470. PMID: 29891507; PMCID: PMC6095720.
      Citations: 33     Fields:    Translation:HumansCells
    4. Cascone T, McKenzie JA, Mbofung RM, Punt S, Wang Z, Xu C, Williams LJ, Wang Z, Bristow CA, Carugo A, Peoples MD, Li L, Karpinets T, Huang L, Malu S, Creasy C, Leahey SE, Chen J, Chen Y, Pelicano H, Bernatchez C, Gopal YNV, Heffernan TP, Hu J, Wang J, Amaria RN, Garraway LA, Huang P, Yang P, Wistuba II, Woodman SE, Roszik J, Davis RE, Davies MA, Heymach JV, Hwu P, Peng W. Increased Tumor Glycolysis Characterizes Immune Resistance to Adoptive T Cell Therapy. Cell Metab. 2018 May 01; 27(5):977-987.e4. PMID: 29628419; PMCID: PMC5932208.
      Citations: 183     Fields:    Translation:HumansAnimalsCells
    5. Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Correction: Novel Role of NOX in Supporting Aerobic Glycolysis in Cancer Cells with Mitochondrial Dysfunction and as a Potential Target for Cancer Therapy. PLoS Biol. 2017 12; 15(12):e1002616. PMID: 29227990; PMCID: PMC5724824.
      Citations: 5     Fields:    
    6. Chen DL, Lu YX, Zhang JX, Wei XL, Wang F, Zeng ZL, Pan ZZ, Yuan YF, Wang FH, Pelicano H, Chiao PJ, Huang P, Xie D, Li YH, Ju HQ, Xu RH. Long non-coding RNA UICLM promotes colorectal cancer liver metastasis by acting as a ceRNA for microRNA-215 to regulate ZEB2 expression. Theranostics. 2017; 7(19):4836-4849. PMID: 29187907; PMCID: PMC5706103.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    7. Liu J, Chen G, Pelicano H, Liao J, Huang J, Feng L, Keating MJ, Huang P. Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism. Oncotarget. 2016 Nov 01; 7(44):71378-71389. PMID: 27655686; PMCID: PMC5342085.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    8. Ogasawara MA, Liu J, Pelicano H, Hammoudi N, Croce CM, Keating MJ, Huang P. Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53. Mitochondrion. 2016 Nov; 31:33-39. PMID: 27650502; PMCID: PMC5108679.
      Citations: 6     Fields:    Translation:HumansAnimals
    9. Chen DL, Ju HQ, Lu YX, Chen LZ, Zeng ZL, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Xu DZ, Zhou ZW, Pelicano H, Huang P, Xie D, Wang FH, Li YH, Xu RH. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. J Exp Clin Cancer Res. 2016 09 13; 35(1):142. PMID: 27620004; PMCID: PMC5020507.
      Citations: 122     Fields:    Translation:HumansAnimalsCells
    10. Ju HQ, Lu YX, Chen DL, Tian T, Mo HY, Wei XL, Liao JW, Wang F, Zeng ZL, Pelicano H, Aguilar M, Jia WH, Xu RH. Redox Regulation of Stem-like Cells Though the CD44v-xCT Axis in Colorectal Cancer: Mechanisms and Therapeutic Implications. Theranostics. 2016; 6(8):1160-75. PMID: 27279909; PMCID: PMC4893643.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    11. Zhang W, Pelicano H, Yin R, Zeng J, Wen T, Ding L, Huang R. Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms. Mol Med Rep. 2015 Nov; 12(5):7374-88. PMID: 26458979; PMCID: PMC4626185.
      Citations: 7     Fields:    Translation:HumansCells
    12. Chen DL, Zhang DS, Lu YX, Chen LZ, Zeng ZL, He MM, Wang FH, Li YH, Zhang HZ, Pelicano H, Zhang W, Xu RH. microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer. Oncotarget. 2015 May 10; 6(13):10868-79. PMID: 25869101; PMCID: PMC4484425.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    13. Chen DL, Wang ZQ, Zeng ZL, Wu WJ, Zhang DS, Luo HY, Wang F, Qiu MZ, Wang DS, Ren C, Wang FH, Chiao LJ, Pelicano H, Huang P, Li YH, Xu RH. Identification of microRNA-214 as a negative regulator of colorectal cancer liver metastasis by way of regulation of fibroblast growth factor receptor 1 expression. Hepatology. 2014 Aug; 60(2):598-609. PMID: 24616020.
      Citations: 78     Fields:    Translation:HumansAnimalsCells
    14. Zhang W, Feng L, Huang P, Pelicano H. [Resistance of chronic lymphocytic leukemia cells in apoptosis: key role of stromal cells in maintaining the redox potential of CLL cells]. Med Sci (Paris). 2013 Jan; 29(1):36-8. PMID: 23351693.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. Lu W, Hu Y, Chen G, Chen Z, Zhang H, Wang F, Feng L, Pelicano H, Wang H, Keating MJ, Liu J, McKeehan W, Wang H, Luo Y, Huang P. Novel role of NOX in supporting aerobic glycolysis in cancer cells with mitochondrial dysfunction and as a potential target for cancer therapy. PLoS Biol. 2012; 10(5):e1001326. PMID: 22589701; PMCID: PMC3348157.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    16. Honeychurch J, Alduaij W, Azizyan M, Cheadle EJ, Pelicano H, Ivanov A, Huang P, Cragg MS, Illidge TM. Antibody-induced nonapoptotic cell death in human lymphoma and leukemia cells is mediated through a novel reactive oxygen species-dependent pathway. Blood. 2012 Apr 12; 119(15):3523-33. PMID: 22354003; PMCID: PMC5944831.
      Citations: 48     Fields:    Translation:HumansCells
    17. Zhang W, Trachootham D, Liu J, Chen G, Pelicano H, Garcia-Prieto C, Lu W, Burger JA, Croce CM, Plunkett W, Keating MJ, Huang P. Stromal control of cystine metabolism promotes cancer cell survival in chronic lymphocytic leukaemia. Nat Cell Biol. 2012 Feb 19; 14(3):276-86. PMID: 22344033; PMCID: PMC3290742.
      Citations: 161     Fields:    Translation:HumansAnimalsCells
    18. Hu Y, Lu W, Chen G, Wang P, Chen Z, Zhou Y, Ogasawara M, Trachootham D, Feng L, Pelicano H, Chiao PJ, Keating MJ, Garcia-Manero G, Huang P. K-ras(G12V) transformation leads to mitochondrial dysfunction and a metabolic switch from oxidative phosphorylation to glycolysis. Cell Res. 2012 Feb; 22(2):399-412. PMID: 21876558; PMCID: PMC3257361.
      Citations: 125     Fields:    Translation:HumansAnimalsCells
    19. Lu W, Pelicano H, Huang P. Cancer metabolism: is glutamine sweeter than glucose? Cancer Cell. 2010 Sep 14; 18(3):199-200. PMID: 20832746; PMCID: PMC2952340.
      Citations: 65     Fields:    
    20. Pelicano H, Lu W, Zhou Y, Zhang W, Chen Z, Hu Y, Huang P. Mitochondrial dysfunction and reactive oxygen species imbalance promote breast cancer cell motility through a CXCL14-mediated mechanism. Cancer Res. 2009 Mar 15; 69(6):2375-83. PMID: 19276362; PMCID: PMC2760349.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    21. Trachootham D, Zhang H, Zhang W, Feng L, Du M, Zhou Y, Chen Z, Pelicano H, Plunkett W, Wierda WG, Keating MJ, Huang P. Effective elimination of fludarabine-resistant CLL cells by PEITC through a redox-mediated mechanism. Blood. 2008 Sep 01; 112(5):1912-22. PMID: 18574029; PMCID: PMC2518893.
      Citations: 80     Fields:    Translation:HumansCells
    22. Demizu Y, Sasaki R, Trachootham D, Pelicano H, Colacino JA, Liu J, Huang P. Alterations of cellular redox state during NNK-induced malignant transformation and resistance to radiation. Antioxid Redox Signal. 2008 May; 10(5):951-61. PMID: 18257743; PMCID: PMC2717788.
      Citations: 7     Fields:    Translation:HumansCells
    23. Hu Y, Lu W, Pelicano H, Huang P, Alexandre J. Novel action of paclitaxel against cancer cells: bystander effect mediated by reactive oxygen species. Cancer Res. 2007 Apr 15; 67(8):3512-7. PMID: 17440056.
      Citations: 131     Fields:    Translation:HumansCells
    24. Xu RH, Du M, Feng L, Sasaki R, Carew JS, Hu Y, Ramdas L, Hu L, Keating MJ, Zhang W, Plunkett W, Huang P, Pelicano H. Mitochondrial respiration defects in cancer cells cause activation of Akt survival pathway through a redox-mediated mechanism. J Cell Biol. 2006 Dec 18; 175(6):913-23. PMID: 17158952; PMCID: PMC2064701.
      Citations: 173     Fields:    Translation:HumansCells
    25. Trachootham D, Zhou Y, Zhang H, Demizu Y, Chen Z, Pelicano H, Chiao PJ, Achanta G, Arlinghaus RB, Liu J, Huang P. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell. 2006 Sep; 10(3):241-52. PMID: 16959615.
      Citations: 440     Fields:    Translation:HumansAnimalsCells
    26. Zeng Z, Samudio IJ, Zhang W, Estrov Z, Harris D, Frolova O, Hail N, Chen W, Kornblau SM, Huang P, Lu Y, Mills GB, Andreeff M, Konopleva M, Pelicano H. Simultaneous inhibition of PDK1/AKT and Fms-like tyrosine kinase 3 signaling by a small-molecule KP372-1 induces mitochondrial dysfunction and apoptosis in acute myelogenous leukemia. Cancer Res. 2006 Apr 01; 66(7):3737-46. PMID: 16585200.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    27. Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M. A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis. Mol Pharmacol. 2006 Apr; 69(4):1182-93. PMID: 16410408.
      Citations: 32     Fields:    Translation:HumansCells
    28. Zhou Y, Garcia-Prieto C, Carney DA, Xu RH, Pelicano H, Kang Y, Yu W, Lou C, Kondo S, Liu J, Harris DM, Estrov Z, Keating MJ, Jin Z, Huang P. OSW-1: a natural compound with potent anticancer activity and a novel mechanism of action. J Natl Cancer Inst. 2005 Dec 07; 97(23):1781-5. PMID: 16333034.
      Citations: 24     Fields:    Translation:HumansCells
    29. Achanta G, Sasaki R, Feng L, Carew JS, Lu W, Pelicano H, Keating MJ, Huang P. Novel role of p53 in maintaining mitochondrial genetic stability through interaction with DNA Pol gamma. EMBO J. 2005 Oct 05; 24(19):3482-92. PMID: 16163384; PMCID: PMC1276176.
      Citations: 133     Fields:    Translation:HumansCells
    30. Xu RH, Pelicano H, Zhou Y, Carew JS, Feng L, Bhalla KN, Keating MJ, Huang P. Inhibition of glycolysis in cancer cells: a novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res. 2005 Jan 15; 65(2):613-21. PMID: 15695406.
      Citations: 292     Fields:    Translation:HumansCells
    31. Fujioka S, Schmidt C, Sclabas GM, Li Z, Peng B, Yao A, Niu J, Zhang W, Evans DB, Abbruzzese JL, Huang P, Chiao PJ, Pelicano H. Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. J Biol Chem. 2004 Jun 25; 279(26):27549-59. PMID: 15102862.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    32. Pelicano H, Carney D, Huang P. ROS stress in cancer cells and therapeutic implications. Drug Resist Updat. 2004 Apr; 7(2):97-110. PMID: 15158766.
      Citations: 584     Fields:    
    33. Mone AP, Huang P, Pelicano H, Cheney CM, Green JM, Tso JY, Johnson AJ, Jefferson S, Lin TS, Byrd JC. Hu1D10 induces apoptosis concurrent with activation of the AKT survival pathway in human chronic lymphocytic leukemia cells. Blood. 2004 Mar 01; 103(5):1846-54. PMID: 14630799.
      Citations: 18     Fields:    Translation:HumansCells
    34. Feng L, Zhou Y, Carew JS, Hileman EO, Plunkett W, Keating MJ, Huang P, Pelicano H. Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism. J Biol Chem. 2003 Sep 26; 278(39):37832-9. PMID: 12853461.
      Citations: 145     Fields:    Translation:HumansCells
    35. Fu L, Pelicano H, Liu J, Huang P, Lee C. The circadian gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell. 2002 Oct 04; 111(1):41-50. PMID: 12372299.
      Citations: 516     Fields:    Translation:AnimalsCells
    36. Zhou Y, Achanta G, Pelicano H, Gandhi V, Plunkett W, Huang P. Action of (E)-2'-deoxy-2'-(fluoromethylene)cytidine on DNA metabolism: incorporation, excision, and cellular response. Mol Pharmacol. 2002 Jan; 61(1):222-9. PMID: 11752224.
      Citations: 7     Fields:    Translation:HumansCells
    37. Pierra C, Eriksson S, Gosselin G, Imbach JL, Maury G, P?licano H. Enzymatic properties of the unnatural beta-L-enantiomers of 2',3'-dideoxyadenosine and 2',3'-didehydro-2',3'-dideoxyadenosine. J Med Chem. 1997 Nov 21; 40(24):3969-73. PMID: 9397178.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    38. Johnson R, Maury G, Imbach JL, Aubertin AM, Obert G, Gosselin G, Benzaria S, P?licano H. Synthesis, in vitro antiviral evaluation, and stability studies of bis(S-acyl-2-thioethyl) ester derivatives of 9-[2-(phosphonomethoxy)ethyl]adenine (PMEA) as potential PMEA prodrugs with improved oral bioavailability. J Med Chem. 1996 Dec 06; 39(25):4958-65. PMID: 8960556.
      Citations: 13     Fields:    Translation:HumansCells
    39. Elimination of chronic lymphocytic leukemia cells in stromal microenvironment by targeting CPT with an antiangina drug perhexiline. Oncogene.
    40. Bis(S-acyl-2-thioethyl)esters of 2',3'-dideoxyadenosine 5'-monophosphate are potent anti-HIV agents in cell culture. Nucleosides and Nucleotides. 14:789-791.
    41. Targeting mitochondria of cancer cells. 183-210.
    42. Erratum. Cell. 111:1055.
    43. Bioorganic and Medicinal Chemistry Letters. 5:2315-2320.
    44. Targeting p53-deficient chronic lymphocytic leukemia cells in vitro and in vivo by ROS-mediated mechanism. Oncotarget. 7:71378-71389.
    45. Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53. Mitochondrion. 31:33-39.
    46. A new synthesis of some 4'-thio-D-ribonucleosides and preliminary enzymatic evaluation. Nucleosides and Nucleotides. 13:2035-2050.
    47. Ligand binding properties of bovine liver adenosine kinase. Nucleosides and Nucleotides. 14:473-476.
    48. New prodrugs of 9-(2-phosphonomethoxyethyl) adenine [PMEA]. Nucleosides and Nucleotides. 14:563-565.
    49. Redox regulation of stem-like cells though the CD44v-xCT axis in colorectal cancer. Theranostics. 6:1160-1175.
    50. Long non-coding RNA XIST regulates gastric cancer progression by acting as a molecular sponge of miR-101 to modulate EZH2 expression. Journal of Experimental and Clinical Cancer Research. 35.
    51. microRNA-217 inhibits tumor progression and metastasis by downregulating EZH2 and predicts favorable prognosis in gastric cancer. Oncotarget. 6:10868-10879.
    52. Effective elimination of chronic lymphocytic leukemia cells in the stromal microenvironment by a novel drug combination strategy using redox-mediated mechanisms. Molecular Medicine Reports. 12:7374-7388.
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