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GUNAPALA SHETTY

TitleAssociate Professor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Parekh PA, Garcia TX, Waheeb R, Jain V, Gandhi P, Meistrich ML, Shetty G, Hofmann MC. Undifferentiated spermatogonia regulate Cyp26b1 expression through NOTCH signaling and drive germ cell differentiation. FASEB J. 2019 Jul; 33(7):8423-8435. PMID: 30991836.
      View in: PubMed
    2. Fayomi AP, Peters K, Sukhwani M, Valli-Pulaski H, Shetty G, Meistrich ML, Houser L, Robertson N, Roberts V, Ramsey C, Hanna C, Hennebold JD, Dobrinski I, Orwig KE. Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science. 2019 03 22; 363(6433):1314-1319. PMID: 30898927.
      View in: PubMed
    3. Sosa E, Chen D, Rojas EJ, Hennebold JD, Peters KA, Wu Z, Lam TN, Mitchell JM, Sukhwani M, Tailor RC, Meistrich ML, Orwig KE, Shetty G, Clark AT. Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche. Nat Commun. 2018 12 17; 9(1):5339. PMID: 30559363.
      View in: PubMed
    4. Shetty G, Mitchell JM, Lam TNA, Wu Z, Zhang J, Hill L, Tailor RC, Peters KA, Penedo MC, Orwig KE, Meistrich ML. Donor spermatogenesis in de novo formed seminiferous tubules from transplanted testicular cells in rhesus monkey testis. Hum Reprod. 2018 12 01; 33(12):2249-2255. PMID: 30358843.
      View in: PubMed
    5. Meistrich ML, Shetty G. The New Director of "the Spermatogonial Niche": Introducing the Peritubular Macrophage. Cell Rep. 2015 Aug 18; 12(7):1069-70. PMID: 26287751.
      View in: PubMed
    6. Comish PB, Drumond AL, Kinnell HL, Anderson RA, Matin A, Meistrich ML, Shetty G. Fetal cyclophosphamide exposure induces testicular cancer and reduced spermatogenesis and ovarian follicle numbers in mice. PLoS One. 2014; 9(4):e93311. PMID: 24691397.
      View in: PubMed
    7. Valli H, Phillips BT, Shetty G, Byrne JA, Clark AT, Meistrich ML, Orwig KE. Germline stem cells: toward the regeneration of spermatogenesis. Fertil Steril. 2014 Jan; 101(1):3-13. PMID: 24314923.
      View in: PubMed
    8. Shetty G, Uthamanthil RK, Zhou W, Shao SH, Weng CC, Tailor RC, Hermann BP, Orwig KE, Meistrich ML. Hormone suppression with GnRH antagonist promotes spermatogenic recovery from transplanted spermatogonial stem cells in irradiated cynomolgus monkeys. Andrology. 2013 Nov; 1(6):886-98. PMID: 24124124.
      View in: PubMed
    9. Albuquerque AV, Almeida FR, Weng CC, Shetty G, Meistrich ML, Chiarini-Garcia H. Spermatogonial behavior in rats during radiation-induced arrest and recovery after hormone suppression. Reproduction. 2013 Oct; 146(4):363-76. PMID: 23884860.
      View in: PubMed
    10. Abuelhija M, Weng CC, Shetty G, Meistrich ML. Rat models of post-irradiation recovery of spermatogenesis: interstrain differences. Andrology. 2013 Mar; 1(2):206-15. PMID: 23413134.
      View in: PubMed
    11. Panneerdoss S, Chang YF, Buddavarapu KC, Chen HI, Shetty G, Wang H, Chen Y, Kumar TR, Rao MK. Androgen-responsive microRNAs in mouse Sertoli cells. PLoS One. 2012; 7(7):e41146. PMID: 22911753.
      View in: PubMed
    12. Shetty G, Comish PB, Weng CC, Matin A, Meistrich ML. Fetal radiation exposure induces testicular cancer in genetically susceptible mice. PLoS One. 2012; 7(2):e32064. PMID: 22348147.
      View in: PubMed
    13. Abuelhija M, Weng CC, Shetty G, Meistrich ML. Differences in radiation sensitivity of recovery of spermatogenesis between rat strains. Toxicol Sci. 2012 Apr; 126(2):545-53. PMID: 22273744.
      View in: PubMed
    14. Shetty G, Porter KL, Zhou W, Shao SH, Weng CC, Meistrich ML. Androgen suppression-induced stimulation of spermatogonial differentiation in juvenile spermatogonial depletion mice acts by elevating the testicular temperature. Endocrinology. 2011 Sep; 152(9):3504-14. PMID: 21733828.
      View in: PubMed
    15. Zhou W, Bolden-Tiller OU, Shao SH, Weng CC, Shetty G, AbuElhija M, Pakarinen P, Huhtaniemi I, Momin AA, Wang J, Stivers DN, Liu Z, Meistrich ML. Estrogen-regulated genes in rat testes and their relationship to recovery of spermatogenesis after irradiation. Biol Reprod. 2011 Oct; 85(4):823-33. PMID: 21653891.
      View in: PubMed
    16. Zhou W, Bolden-Tiller OU, Shetty G, Shao SH, Weng CC, Pakarinen P, Liu Z, Stivers DN, Meistrich ML. Changes in gene expression in somatic cells of rat testes resulting from hormonal modulation and radiation-induced germ cell depletion. Biol Reprod. 2010 Jan; 82(1):54-65. PMID: 19684331.
      View in: PubMed
    17. Porter KL, Shetty G, Shuttlesworth GA, Weng CC, Huhtaniemi I, Pakarinen P, Meistrich ML. Estrogen enhances recovery from radiation-induced spermatogonial arrest in rat testes. J Androl. 2009 Jul-Aug; 30(4):440-51. PMID: 19136390.
      View in: PubMed
    18. Zhang Z, Shao S, Shetty G, Meistrich ML. Donor Sertoli cells transplanted into irradiated rat testes stimulate partial recovery of endogenous spermatogenesis. Reproduction. 2009 Mar; 137(3):497-508. PMID: 19036951.
      View in: PubMed
    19. Dakhova O, O'Day D, Kinet N, Yucer N, Wiese M, Shetty G, Ducy P. Dickkopf-like1 regulates postpubertal spermatocyte apoptosis and testosterone production. Endocrinology. 2009 Jan; 150(1):404-12. PMID: 18818293.
      View in: PubMed
    20. Meistrich ML, Shetty G. Hormonal suppression for fertility preservation in males and females. Reproduction. 2008 Dec; 136(6):691-701. PMID: 18515310.
      View in: PubMed
    21. Shetty G, Shao SH, Weng CC. p53-dependent apoptosis in the inhibition of spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Endocrinology. 2008 Jun; 149(6):2773-81. PMID: 18356279.
      View in: PubMed
    22. Shetty G, Meistrich ML. The missing niche for spermatogonial stem cells: do blood vessels point the way? Cell Stem Cell. 2007 Oct 11; 1(4):361-3. PMID: 18371373.
      View in: PubMed
    23. Bolden-Tiller OU, Chiarini-Garcia H, Poirier C, Alves-Freitas D, Weng CC, Shetty G, Meistrich ML. Genetic factors contributing to defective spermatogonial differentiation in juvenile spermatogonial depletion (Utp14bjsd) mice. Biol Reprod. 2007 Aug; 77(2):237-46. PMID: 17475932.
      View in: PubMed
    24. Shetty G, Weng CC, Porter KL, Zhang Z, Pakarinen P, Kumar TR, Meistrich ML. Spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice with androgen receptor or follicle-stimulating hormone mutations. Endocrinology. 2006 Jul; 147(7):3563-70. PMID: 16627582.
      View in: PubMed
    25. Porter KL, Shetty G, Meistrich ML. Testicular edema is associated with spermatogonial arrest in irradiated rats. Endocrinology. 2006 Mar; 147(3):1297-305. PMID: 16306082.
      View in: PubMed
    26. Shetty G, Weng CC, Meachem SJ, Bolden-Tiller OU, Zhang Z, Pakarinen P, Huhtaniemi I, Meistrich ML. Both testosterone and follicle-stimulating hormone independently inhibit spermatogonial differentiation in irradiated rats. Endocrinology. 2006 Jan; 147(1):472-82. PMID: 16210366.
      View in: PubMed
    27. Boekelheide K, Schoenfeld HA, Hall SJ, Weng CC, Shetty G, Leith J, Harper J, Sigman M, Hess DL, Meistrich ML. Gonadotropin-releasing hormone antagonist (Cetrorelix) therapy fails to protect nonhuman primates (Macaca arctoides) from radiation-induced spermatogenic failure. J Androl. 2005 Mar-Apr; 26(2):222-34. PMID: 15713828.
      View in: PubMed
    28. Shetty G, Meistrich ML. Hormonal approaches to preservation and restoration of male fertility after cancer treatment. J Natl Cancer Inst Monogr. 2005; (34):36-9. PMID: 15784820.
      View in: PubMed
    29. Shetty G, Weng CC, Bolden-Tiller OU, Huhtaniemi I, Handelsman DJ, Meistrich ML. Effects of medroxyprogesterone and estradiol on the recovery of spermatogenesis in irradiated rats. Endocrinology. 2004 Oct; 145(10):4461-9. PMID: 15205377.
      View in: PubMed
    30. Meistrich ML, Wilson G, Porter KL, Huhtaniemi I, Shetty G, Shuttlesworth GA. Restoration of spermatogenesis in dibromochloropropane (DBCP)-treated rats by hormone suppression. Toxicol Sci. 2003 Dec; 76(2):418-26. PMID: 14514963.
      View in: PubMed
    31. Shetty G, Weng CC. Cryptorchidism rescues spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mice. Endocrinology. 2004 Jan; 145(1):126-33. PMID: 14500567.
      View in: PubMed
    32. Meistrich ML, Shetty G. Suppression of testosterone stimulates recovery of spermatogenesis after cancer treatment. Int J Androl. 2003 Jun; 26(3):141-6. PMID: 12755992.
      View in: PubMed
    33. Meistrich ML, Shetty G. Inhibition of spermatogonial differentiation by testosterone. J Androl. 2003 Mar-Apr; 24(2):135-48. PMID: 12634296.
      View in: PubMed
    34. Meistrich ML, Wilson G, Shetty G, Shuttlesworth GA. Restoration of spermatogenesis after exposure to toxicants: genetic implications. Adv Exp Med Biol. 2003; 518:227-37. PMID: 12817691.
      View in: PubMed
    35. Shetty G, Wilson G, Hardy MP, Niu E, Huhtaniemi I, Meistrich ML. Inhibition of recovery of spermatogenesis in irradiated rats by different androgens. Endocrinology. 2002 Sep; 143(9):3385-96. PMID: 12193551.
      View in: PubMed
    36. Shetty G, Wilson G, Huhtaniemi I, Boettger-Tong H, Meistrich ML. Testosterone inhibits spermatogonial differentiation in juvenile spermatogonial depletion mice. Endocrinology. 2001 Jul; 142(7):2789-95. PMID: 11415997.
      View in: PubMed
    37. Maiti S, Meistrich ML, Wilson G, Shetty G, Marcelli M, McPhaul MJ, Morris PL, Wilkinson MF. Irradiation selectively inhibits expression from the androgen-dependent Pem homeobox gene promoter in sertoli cells. Endocrinology. 2001 Apr; 142(4):1567-77. PMID: 11250938.
      View in: PubMed
    38. Rao J, Seshagiri PB, Shetty G, Ramesh G, Adiga PR. Active immunization against riboflavin carrier protein results in peri-implantation embryonic loss leading to pregnancy termination in rats: use of alternate adjuvants. Indian J Exp Biol. 2000 Sep; 38(9):863-72. PMID: 12561942.
      View in: PubMed
    39. Shetty G, Wilson G, Huhtaniemi I, Shuttlesworth GA, Reissmann T, Meistrich ML. Gonadotropin-releasing hormone analogs stimulate and testosterone inhibits the recovery of spermatogenesis in irradiated rats. Endocrinology. 2000 May; 141(5):1735-45. PMID: 10803584.
      View in: PubMed
    40. Shuttlesworth GA, de Rooij DG, Huhtaniemi I, Reissmann T, Russell LD, Shetty G, Wilson G, Meistrich ML. Enhancement of A spermatogonial proliferation and differentiation in irradiated rats by gonadotropin-releasing hormone antagonist administration. Endocrinology. 2000 Jan; 141(1):37-49. PMID: 10614621.
      View in: PubMed
    41. Matsumiya K, Meistrich ML, Shetty G, Dohmae K, Tohda A, Okuyama A, Nishimune Y. Stimulation of spermatogonial differentiation in juvenile spermatogonial depletion (jsd) mutant mice by gonadotropin-releasing hormone antagonist treatment. Endocrinology. 1999 Oct; 140(10):4912-5. PMID: 10499552.
      View in: PubMed
    42. Shetty G, Krishnamurthy H, Krishnamurthy HN, Bhatnagar AS, Moudgal NR. Effect of long-term treatment with aromatase inhibitor on testicular function of adult male bonnet monkeys (M. radiata). Steroids. 1998 Jul-Aug; 63(7-8):414-20. PMID: 9654648.
      View in: PubMed
    43. Shetty G, Krishnamurthy H, Krishnamurthy HN, Ramachandra SG, Moudgal NR. Use of norethisterone and estradiol in mini doses as a contraceptive in the male. Efficacy studies in the adult male bonnet monkey (Macaca radiata). Contraception. 1997 Oct; 56(4):257-65. PMID: 9408708.
      View in: PubMed
    44. Shetty G, Krishnamurthy H, Krishnamurthy HN, Bhatnagar S, Moudgal RN. Effect of estrogen deprivation on the reproductive physiology of male and female primates. J Steroid Biochem Mol Biol. 1997 Apr; 61(3-6):157-66. PMID: 9365186.
      View in: PubMed
    45. Moudgal NR, Shetty G, Selvaraj N, Bhatnagar AS. Use of a specific aromatase inhibitor for determining whether there is a role for oestrogen in follicle/oocyte maturation, ovulation and preimplantation embryo development. J Reprod Fertil Suppl. 1996; 50:69-81. PMID: 8984190.
      View in: PubMed
    46. Shetty G, Bhatnagar AS, Moudgal NR. Blockade of estrogen synthesis with an aromatase inhibitor affects luteal function of the pseudopregnant rat. J Steroid Biochem Mol Biol. 1995 Dec; 55(3-4):347-53. PMID: 8541231.
      View in: PubMed
    47. Selvaraj N, Shetty G, Vijayalakshmi K, Bhatnagar AS, Moudgal NR. Effect of blocking oestrogen synthesis with a new generation aromatase inhibitor CGS 16949A on follicular maturation induced by pregnant mare serum gonadotrophin in the immature rat. J Endocrinol. 1994 Sep; 142(3):563-70. PMID: 7964306.
      View in: PubMed
    48. Application of spermatogenesis suppression therapies for fertility preservation. 203-212.
    49. Prevention of adverse effects of cancer treatment on the germline. 114-123.
    50. Increasing testicular temperature by exposure to elevated ambient temperatures restores spermatogenesis in adult Utp 14b <sup>jsd</sup> mutant (jsd) mice. Andrology. 3:376-384.
    51. Leydig cells contribute to the inhibition of spermatogonial differentiation after irradiation of the rat. Andrology.
    52. Germline stem cells. Fertility and Sterility. 101:3-13.
    53. Once-a-month injection of norethisterone enanthate and estradiol valerate combination suppresses pituitary FSH/LH secretion and testicular function in man. Current Science. 82:550-553.
    54. Erratum. Endocrinology. 148:102.
    55. Hormones and Spermatogonial Development. 437-448.
    56. Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene.
    57. Hormonal suppression for fertility preservation in the male. 164-175.
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