TIMOTHY J MCDONNELL

TitleProfessor
InstitutionMD Anderson
DepartmentHematopathology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Fang H, Wang SA, Khoury JD, El Hussein S, Kim DH, Tashakori M, Tang Z, Li S, Hu Z, Jelloul FZ, Patel KP, McDonnell TJ, Kadia T, Medeiros LJ, Wang W. Pure erythroid leukemia is characterized by biallelic TP53 inactivation and abnormal p53 expression patterns in de novo and secondary cases. Haematologica. 2022 May 05. PMID: 35511670.
      Citations:    Fields:    
    2. Martinez-Baquero D, Sakhdari A, Mo H, Kim DH, Kanagal-Shamanna R, Li S, Young KH, O'Malley DP, Dogan A, Jain P, Wang ML, McDonnell TJ, Miranda RN, Vega F, Medeiros LJ, Ok CY. EZH2 expression is associated with inferior overall survival in mantle cell lymphoma. Mod Pathol. 2021 12; 34(12):2183-2191. PMID: 34376807.
      Citations:    Fields:    Translation:HumansCells
    3. O'Callaghan M, Fabre A, McCann J, Healy G, McCarthy A, Keane MP, McDonnell TJ, McCarthy C. A 34-Year-Old Man With a Chylothorax and Bony Pain. Chest. 2020 04; 157(4):e131-e136. PMID: 32252938.
      Citations: 1     Fields:    Translation:Humans
    4. Liu H, Miao Y, Ferrajoli A, Tang G, McDonnell T, Medeiros LJ, Hu S. Leukemic phase of Richter transformation: A mimic of acute myeloid leukemia that responded to Ibrutinib monotherapy. Am J Hematol. 2020 Mar 12. PMID: 32162729.
      Citations:    Fields:    
    5. Xu J, Liu JL, Medeiros LJ, Huang W, Khoury JD, McDonnell TJ, Tang G, Schlette E, Yin CC, Bueso-Ramos CE, Lin P, Li S. MYC rearrangement and MYC/BCL2 double expression but not cell-of-origin predict prognosis in R-CHOP treated diffuse large B-cell lymphoma. Eur J Haematol. 2020 Apr; 104(4):336-343. PMID: 31944390.
      Citations: 4     Fields:    Translation:Humans
    6. Gong Z, Medeiros LJ, Cortes JE, Chen Z, Zheng L, Li Y, Bai S, Lin P, Miranda RN, Jorgensen JL, McDonnell TJ, Wang W, Kantarjian HM, Hu S. Cytogenetics-based risk prediction of blastic transformation of chronic myeloid leukemia in the era of TKI therapy. Blood Adv. 2017 Dec 12; 1(26):2541-2552. PMID: 29296906.
      Citations: 13     Fields:    
    7. Lee S, Rodriguez-Villanueva J, McDonnell T. Restrained Terminal Differentiation and Sustained Stemness in Neonatal Skin by Ha-Ras and Bcl-2. Am J Dermatopathol. 2017 Mar; 39(3):199-203. PMID: 27655119.
      Citations:    Fields:    Translation:AnimalsCells
    8. Hidalgo Lopez JE, Yabe M, Carballo-Zarate AA, Wang SA, Jorgensen JL, Ahmed S, Lee J, Li S, Schlette E, McDonnell T, Miranda RN, Medeiros LJ, Bueso-Ramos CE, Yin CC. Donor-Derived T-Cell Large Granular Lymphocytic Leukemia in a Patient With Peripheral T-Cell Lymphoma. J Natl Compr Canc Netw. 2016 08; 14(8):939-44. PMID: 27496109.
      Citations: 4     Fields:    Translation:HumansCells
    9. Ishizawa J, Kojima K, Chachad D, Ruvolo P, Ruvolo V, Jacamo RO, Borthakur G, Mu H, Zeng Z, Tabe Y, Allen JE, Wang Z, Ma W, Lee HC, Orlowski R, Sarbassov dos D, Lorenzi PL, Huang X, Neelapu SS, McDonnell T, Miranda RN, Wang M, Kantarjian H, Konopleva M, Davis RE, Andreeff M. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Sci Signal. 2016 Feb 16; 9(415):ra17. PMID: 26884599.
      Citations: 86     Fields:    Translation:AnimalsCells
    10. Xu-Monette ZY, Dabaja BS, Wang X, Tu M, Manyam GC, Tzankov A, Xia Y, Zhang L, Sun R, Visco C, Dybkaer K, Yin L, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Zhao X, Winter JN, Piris MA, McDonnell TJ, Miranda RN, Li Y, Medeiros LJ, Young KH. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Mod Pathol. 2015 Dec; 28(12):1555-73. PMID: 26541272.
      Citations: 21     Fields:    Translation:HumansCells
    11. Wang W, Cortes JE, Lin P, Beaty MW, Ai D, Amin HM, McDonnell TJ, Ok CY, Kantarjian HM, Medeiros LJ, Hu S. Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood. 2015 Oct 01; 126(14):1699-706. PMID: 26243778.
      Citations: 17     Fields:    Translation:HumansCells
    12. Teo AE, Chen Z, Miranda RN, McDonnell T, Medeiros LJ, McCarty N. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1. Leukemia. 2016 Mar; 30(3):580-93. PMID: 26073757.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    13. Yoshimura M, Ishizawa J, Ruvolo V, Dilip A, Quintás-Cardama A, McDonnell TJ, Neelapu SS, Kwak LW, Shacham S, Kauffman M, Tabe Y, Yokoo M, Kimura S, Andreeff M, Kojima K. Induction of p53-mediated transcription and apoptosis by exportin-1 (XPO1) inhibition in mantle cell lymphoma. Cancer Sci. 2014 Jul; 105(7):795-801. PMID: 24766216.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    14. Tzankov A, Xu-Monette ZY, Gerhard M, Visco C, Dirnhofer S, Gisin N, Dybkaer K, Orazi A, Bhagat G, Richards KL, Hsi ED, Choi WW, van Krieken JH, Ponzoni M, Ferreri AJ, Ye Q, Winter JN, Farnen JP, Piris MA, Møller MB, You MJ, McDonnell T, Medeiros LJ, Young KH. Rearrangements of MYC gene facilitate risk stratification in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Mod Pathol. 2014 Jul; 27(7):958-71. PMID: 24336156.
      Citations: 48     Fields:    Translation:Humans
    15. McCarthy C, Brennan JR, Brown L, Donaghy D, Jones P, Whelan R, McCormack N, Callanan I, Ryan J, McDonnell TJ. Use of a care bundle in the emergency department for acute exacerbations of chronic obstructive pulmonary disease: a feasibility study. Int J Chron Obstruct Pulmon Dis. 2013; 8:605-11. PMID: 24348033.
      Citations: 11     Fields:    Translation:Humans
    16. Hu S, Bueso-Ramos CE, Verstovsek S, Miranda RN, Yin CC, McDonnell T, Medeiros LJ, Lin P. Metastatic splenic angiosarcoma presenting with thrombocytopenia and bone marrow fibrosis mimicking idiopathic thrombocytopenic purpura and primary myelofibrosis: a diagnostic challenge. Clin Lymphoma Myeloma Leuk. 2013 Oct; 13(5):629-33. PMID: 23800601.
      Citations: 3     Fields:    Translation:Humans
    17. Chari NS, Romano RA, Koster MI, Jaks V, Roop D, Flores ER, Teglund S, Sinha S, Gruber W, Aberger F, Medeiros LJ, Toftgard R, McDonnell TJ. Interaction between the TP63 and SHH pathways is an important determinant of epidermal homeostasis. Cell Death Differ. 2013 Aug; 20(8):1080-8. PMID: 23686138.
      Citations: 14     Fields:    Translation:AnimalsCells
    18. Xu-Monette ZY, Medeiros LJ, Li Y, Orlowski RZ, Andreeff M, Bueso-Ramos CE, Greiner TC, McDonnell TJ, Young KH. Dysfunction of the TP53 tumor suppressor gene in lymphoid malignancies. Blood. 2012 Apr 19; 119(16):3668-83. PMID: 22275381.
      Citations: 65     Fields:    Translation:HumansCells
    19. Piya S, White EJ, Klein SR, Jiang H, McDonnell TJ, Gomez-Manzano C, Fueyo J. The E1B19K oncoprotein complexes with Beclin 1 to regulate autophagy in adenovirus-infected cells. PLoS One. 2011; 6(12):e29467. PMID: 22242123.
      Citations: 24     Fields:    Translation:HumansCells
    20. Zhou Y, Tang G, Medeiros LJ, McDonnell TJ, Keating MJ, Wierda WG, Wang SA. Therapy-related myeloid neoplasms following fludarabine, cyclophosphamide, and rituximab (FCR) treatment in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma. Mod Pathol. 2012 Feb; 25(2):237-45. PMID: 22080061.
      Citations: 24     Fields:    Translation:Humans
    21. Kadowaki Y, Chari NS, Teo AE, Hashi A, Spurgers KB, McDonnell TJ. PI3 Kinase inhibition on TRAIL-induced apoptosis correlates with androgen-sensitivity and p21 expression in prostate cancer cells. Apoptosis. 2011 Jun; 16(6):627-35. PMID: 21437722.
      Citations: 4     Fields:    Translation:HumansCells
    22. Kelly E, Mhurchu EN, Sukor S, McDonnell TJ, Tryfonopoulos D, Keane MP. Chemotherapy-associated recurrent pneumothoraces in lymphangioleiomyomatosis. Respir Care. 2010 Nov; 55(11):1491-4. PMID: 20979677.
      Citations: 1     Fields:    Translation:Humans
    23. Jiang H, Martin V, Gomez-Manzano C, Johnson DG, Alonso M, White E, Xu J, McDonnell TJ, Shinojima N, Fueyo J. The RB-E2F1 pathway regulates autophagy. Cancer Res. 2010 Oct 15; 70(20):7882-93. PMID: 20807803.
      Citations: 70     Fields:    Translation:HumansCells
    24. Wang SA, Jabbar K, Lu G, Chen SS, Galili N, Vega F, Jones D, Raza A, Kantarjian H, Garcia-Manero G, McDonnell TJ, Medeiros LJ. Trisomy 11 in myelodysplastic syndromes defines a unique group of disease with aggressive clinicopathologic features. Leukemia. 2010 Apr; 24(4):740-7. PMID: 20072149.
      Citations: 8     Fields:    Translation:HumansCells
    25. Liang M, Han X, Vadhan-Raj S, Nguyen M, Zhang YH, Fernandez M, Drakos E, Konoplev SN, Yin CC, Miranda RN, McDonnell TJ, Medeiros LJ, Bueso-Ramos CE. HDM4 is overexpressed in mantle cell lymphoma and its inhibition induces p21 expression and apoptosis. Mod Pathol. 2010 Mar; 23(3):381-91. PMID: 20062013.
      Citations: 8     Fields:    Translation:HumansCells
    26. Martin J, Walsh C, Gibbs A, McDonnell T, Fearon U, Keane J, Codd MB, Dodd J, Veale D, Fitzgerald O, Bresnihan B. Comparison of interferon {gamma} release assays and conventional screening tests before tumour necrosis factor {alpha} blockade in patients with inflammatory arthritis. Ann Rheum Dis. 2010 Jan; 69(1):181-5. PMID: 19176545.
      Citations: 20     Fields:    Translation:HumansPHPublic Health
    27. Chari NS, Pinaire NL, Thorpe L, Medeiros LJ, Routbort MJ, McDonnell TJ. The p53 tumor suppressor network in cancer and the therapeutic modulation of cell death. Apoptosis. 2009 Apr; 14(4):336-47. PMID: 19229632.
      Citations: 22     Fields:    Translation:HumansAnimals
    28. Tsavachidou D, McDonnell TJ, Wen S, Wang X, Vakar-Lopez F, Pisters LL, Pettaway CA, Wood CG, Do KA, Thall PF, Stephens C, Efstathiou E, Taylor R, Menter DG, Troncoso P, Lippman SM, Logothetis CJ, Kim J. Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer. J Natl Cancer Inst. 2009 Mar 04; 101(5):306-20. PMID: 19244175.
      Citations: 26     Fields:    Translation:HumansCTClinical Trials
    29. McDonnell TJ, Chari NS, Cho-Vega JH, Troncoso P, Wang X, Bueso-Ramos CE, Coombes K, Brisbay S, Lopez R, Prendergast G, Logothetis C, Do KA. Biomarker expression patterns that correlate with high grade features in treatment naive, organ-confined prostate cancer. BMC Med Genomics. 2008 Jan 31; 1:1. PMID: 18237448.
      Citations: 6     Fields:    
    30. Cho-Vega JH, Tsavachidis S, Do KA, Nakagawa J, Medeiros LJ, McDonnell TJ. Dicarbonyl/L-xylulose reductase: a potential biomarker identified by laser-capture microdissection-micro serial analysis of gene expression of human prostate adenocarcinoma. Cancer Epidemiol Biomarkers Prev. 2007 Dec; 16(12):2615-22. PMID: 18086765.
      Citations: 9     Fields:    Translation:HumansCells
    31. Lee S, Chari NS, Kim HW, Wang X, Roop DR, Cho SH, DiGiovanni J, McDonnell TJ. Cooperation of Ha-ras and Bcl-2 during multistep skin carcinogenesis. Mol Carcinog. 2007 Dec; 46(12):949-57. PMID: 17538944.
      Citations: 4     Fields:    Translation:AnimalsCells
    32. Leroux ME, Auzenne E, Evans R, Hail N, Spohn W, Ghosh SC, Farquhar D, McDonnell T, Klostergaard J. Sphingolipids and the sphingosine kinase inhibitor, SKI II, induce BCL-2-independent apoptosis in human prostatic adenocarcinoma cells. Prostate. 2007 Nov 01; 67(15):1699-717. PMID: 17879964.
      Citations: 12     Fields:    Translation:HumansCells
    33. Chari NS, McDonnell TJ. The sonic hedgehog signaling network in development and neoplasia. Adv Anat Pathol. 2007 Sep; 14(5):344-52. PMID: 17717435.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    34. Efstathiou E, Troncoso P, Wen S, Do KA, Pettaway CA, Pisters LL, McDonnell TJ, Logothetis CJ. Initial modulation of the tumor microenvironment accounts for thalidomide activity in prostate cancer. Clin Cancer Res. 2007 Feb 15; 13(4):1224-31. PMID: 17317833.
      Citations: 24     Fields:    Translation:HumansCellsCTClinical Trials
    35. Wang J, Do KA, Wen S, Tsavachidis S, McDonnell TJ, Logothetis CJ, Coombes KR. Merging microarray data, robust feature selection, and predicting prognosis in prostate cancer. Cancer Inform. 2007 Feb 14; 2:87-97. PMID: 19458761.
      Citations: 14     
    36. Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE. HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Mod Pathol. 2007 Jan; 20(1):54-62. PMID: 17143258.
      Citations: 25     Fields:    Translation:HumansCells
    37. Khor LY, Desilvio M, Li R, McDonnell TJ, Hammond ME, Sause WT, Pilepich MV, Okunieff P, Sandler HM, Pollack A. Bcl-2 and bax expression and prostate cancer outcome in men treated with radiotherapy in Radiation Therapy Oncology Group protocol 86-10. Int J Radiat Oncol Biol Phys. 2006 Sep 01; 66(1):25-30. PMID: 16814949.
      Citations: 14     Fields:    Translation:Humans
    38. Spurgers KB, Gold DL, Coombes KR, Bohnenstiehl NL, Mullins B, Meyn RE, Logothetis CJ, McDonnell TJ. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem. 2006 Sep 01; 281(35):25134-42. PMID: 16798743.
      Citations: 60     Fields:    Translation:HumansCells
    39. Spurgers KB, Chari NS, Bohnenstiehl NL, McDonnell TJ. Molecular mediators of cell death in multistep carcinogenesis: a path to targeted therapy. Cell Death Differ. 2006 Aug; 13(8):1360-70. PMID: 16763617.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    40. Broom BM, McDonnell TJ, Subramanian D. Predicting altered pathways using extendable scaffolds. Int J Bioinform Res Appl. 2006; 2(1):3-18. PMID: 18048150.
      Citations: 2     Fields:    Translation:Humans
    41. Kim J, Sun P, Lam YW, Troncoso P, Sabichi AL, Babaian RJ, Pisters LL, Pettaway CA, Wood CG, Lippman SM, McDonnell TJ, Lieberman R, Logothetis C, Ho SM. Changes in serum proteomic patterns by presurgical alpha-tocopherol and L-selenomethionine supplementation in prostate cancer. Cancer Epidemiol Biomarkers Prev. 2005 Jul; 14(7):1697-702. PMID: 16030104.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    42. Bueso-Ramos C, Xu Y, McDonnell TJ, Brisbay S, Pierce S, Kantarjian H, Rosner G, Garcia-Manero G. Protein expression of a triad of frequently methylated genes, p73, p57Kip2, and p15, has prognostic value in adult acute lymphocytic leukemia independently of its methylation status. J Clin Oncol. 2005 Jun 10; 23(17):3932-9. PMID: 15851765.
      Citations: 11     Fields:    Translation:HumansCells
    43. Cho-Vega JH, Troncoso P, Do KA, Rago C, Wang X, Tsavachidis S, Medeiros LJ, Spurgers K, Logothetis C, McDonnell TJ. Combined laser capture microdissection and serial analysis of gene expression from human tissue samples. Mod Pathol. 2005 Apr; 18(4):577-84. PMID: 15529182.
      Citations: 5     Fields:    Translation:Humans
    44. Bigelow RL, Jen EY, Delehedde M, Chari NS, McDonnell TJ. Sonic hedgehog induces epidermal growth factor dependent matrix infiltration in HaCaT keratinocytes. J Invest Dermatol. 2005 Feb; 124(2):457-65. PMID: 15675968.
      Citations: 29     Fields:    Translation:HumansCells
    45. Assikis VJ, Do KA, Wen S, Wang X, Cho-Vega JH, Brisbay S, Lopez R, Logothetis CJ, Troncoso P, Papandreou CN, McDonnell TJ. Clinical and biomarker correlates of androgen-independent, locally aggressive prostate cancer with limited metastatic potential. Clin Cancer Res. 2004 Oct 15; 10(20):6770-8. PMID: 15501953.
      Citations: 9     Fields:    Translation:Humans
    46. Cho-Vega JH, Rassidakis GZ, Admirand JH, Oyarzo M, Ramalingam P, Paraguya A, McDonnell TJ, Amin HM, Medeiros LJ. MCL-1 expression in B-cell non-Hodgkin's lymphomas. Hum Pathol. 2004 Sep; 35(9):1095-100. PMID: 15343511.
      Citations: 33     Fields:    Translation:HumansCells
    47. Resetkova E, Gonzalez-Angulo AM, Sneige N, Mcdonnell TJ, Buzdar AU, Kau SW, Yamamura Y, Reuben JM, Hortobagyi GN, Cristofanilli M. Prognostic value of P53, MDM-2, and MUC-1 for patients with inflammatory breast carcinoma. Cancer. 2004 Sep 01; 101(5):913-7. PMID: 15329897.
      Citations: 3     Fields:    Translation:HumansCells
    48. Amin HM, McDonnell TJ, Ma Y, Lin Q, Fujio Y, Kunisada K, Leventaki V, Das P, Rassidakis GZ, Cutler C, Medeiros LJ, Lai R. Selective inhibition of STAT3 induces apoptosis and G(1) cell cycle arrest in ALK-positive anaplastic large cell lymphoma. Oncogene. 2004 Jul 15; 23(32):5426-34. PMID: 15184887.
      Citations: 67     Fields:    Translation:HumansCells
    49. Majumder PK, Febbo PG, Bikoff R, Berger R, Xue Q, McMahon LM, Manola J, Brugarolas J, McDonnell TJ, Golub TR, Loda M, Lane HA, Sellers WR. mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways. Nat Med. 2004 Jun; 10(6):594-601. PMID: 15156201.
      Citations: 377     Fields:    Translation:HumansAnimalsCells
    50. Pisters LL, Pettaway CA, Troncoso P, McDonnell TJ, Stephens LC, Wood CG, Do KA, Brisbay SM, Wang X, Hossan EA, Evans RB, Soto C, Jacobson MG, Parker K, Merritt JA, Steiner MS, Logothetis CJ. Evidence that transfer of functional p53 protein results in increased apoptosis in prostate cancer. Clin Cancer Res. 2004 Apr 15; 10(8):2587-93. PMID: 15102659.
      Citations: 13     Fields:    Translation:HumansCells
    51. Rosser CJ, Tanaka M, Pisters LL, Tanaka N, Levy LB, Hoover DC, Grossman HB, McDonnell TJ, Kuban DA, Meyn RE. Adenoviral-mediated PTEN transgene expression sensitizes Bcl-2-expressing prostate cancer cells to radiation. Cancer Gene Ther. 2004 Apr; 11(4):273-9. PMID: 14765130.
      Citations: 14     Fields:    Translation:HumansCells
    52. Honda T, Coppola S, Ghibelli L, Cho SH, Kagawa S, Spurgers KB, Brisbay SM, Roth JA, Meyn RE, Fang B, McDonnell TJ. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Cancer Gene Ther. 2004 Apr; 11(4):249-55. PMID: 15002033.
      Citations: 14     Fields:    Translation:HumansCells
    53. Spurgers KB, Coombes KR, Meyn RE, Gold DL, Logothetis CJ, Johnson TJ, McDonnell TJ. A comprehensive assessment of p53-responsive genes following adenoviral-p53 gene transfer in Bcl-2-expressing prostate cancer cells. Oncogene. 2004 Mar 04; 23(9):1712-23. PMID: 14647426.
      Citations: 4     Fields:    Translation:HumansCells
    54. Nam DH, Park K, Park C, Im YH, Kim MH, Lee S, Hong SC, Shin HJ, Kim JH, Eoh W, McDonnell TJ. Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib. Oncol Rep. 2004 Feb; 11(2):263-8. PMID: 14719052.
      Citations: 16     Fields:    Translation:Animals
    55. Drakos E, Rassidakis GZ, Lai R, Herling M, O'Connor SL, Schmitt-Graeff A, McDonnell TJ, Medeiros LJ. Caspase-3 activation in systemic anaplastic large-cell lymphoma. Mod Pathol. 2004 Jan; 17(1):109-16. PMID: 14657946.
      Citations: 4     Fields:    Translation:HumansCells
    56. Bigelow RL, Chari NS, Unden AB, Spurgers KB, Lee S, Roop DR, Toftgard R, McDonnell TJ. Transcriptional regulation of bcl-2 mediated by the sonic hedgehog signaling pathway through gli-1. J Biol Chem. 2004 Jan 09; 279(2):1197-205. PMID: 14555646.
      Citations: 92     Fields:    Translation:HumansAnimalsCells
    57. Amin HM, Medeiros LJ, Ma Y, Feretzaki M, Das P, Leventaki V, Rassidakis GZ, O'Connor SL, McDonnell TJ, Lai R. Inhibition of JAK3 induces apoptosis and decreases anaplastic lymphoma kinase activity in anaplastic large cell lymphoma. Oncogene. 2003 Aug 21; 22(35):5399-407. PMID: 12934099.
      Citations: 41     Fields:    Translation:HumansAnimals
    58. Tsao AS, McDonnell T, Lam S, Putnam JB, Bekele N, Hong WK, Kurie JM. Increased phospho-AKT (Ser(473)) expression in bronchial dysplasia: implications for lung cancer prevention studies. Cancer Epidemiol Biomarkers Prev. 2003 Jul; 12(7):660-4. PMID: 12869408.
      Citations: 55     Fields:    Translation:Humans
    59. Rassidakis GZ, Jones D, Lai R, Ramalingam P, Sarris AH, McDonnell TJ, Medeiros LJ. BCL-2 family proteins in peripheral T-cell lymphomas: correlation with tumour apoptosis and proliferation. J Pathol. 2003 Jun; 200(2):240-8. PMID: 12754745.
      Citations: 21     Fields:    Translation:Humans
    60. Bruckheimer EM, Spurgers K, Weigel NL, Logothetis C, McDonnell TJ. Regulation of Bcl-2 expression by dihydrotestosterone in hormone sensitive LNCaP-FGC prostate cancer cells. J Urol. 2003 Apr; 169(4):1553-7. PMID: 12629413.
      Citations: 8     Fields:    Translation:HumansCells
    61. Amin HM, McDonnell TJ, Medeiros LJ, Rassidakis GZ, Leventaki V, O'Connor SL, Keating MJ, Lai R. Characterization of 4 mantle cell lymphoma cell lines. Arch Pathol Lab Med. 2003 Apr; 127(4):424-31. PMID: 12683869.
      Citations: 56     Fields:    Translation:HumansCells
    62. Aranha O, Grignon R, Fernandes N, McDonnell TJ, Wood DP, Sarkar FH. Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis. Int J Oncol. 2003 Apr; 22(4):787-94. PMID: 12632069.
      Citations: 28     Fields:    Translation:HumansCells
    63. Pollack A, Cowen D, Troncoso P, Zagars GK, von Eschenbach AC, Meistrich ML, McDonnell T. Molecular markers of outcome after radiotherapy in patients with prostate carcinoma: Ki-67, bcl-2, bax, and bcl-x. Cancer. 2003 Apr 01; 97(7):1630-8. PMID: 12655519.
      Citations: 28     Fields:    Translation:Humans
    64. Sah NK, Munshi A, Kurland JF, McDonnell TJ, Su B, Meyn RE. Translation inhibitors sensitize prostate cancer cells to apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) by activating c-Jun N-terminal kinase. J Biol Chem. 2003 Jun 06; 278(23):20593-602. PMID: 12663665.
      Citations: 16     Fields:    Translation:HumansCells
    65. Milas I, Komaki R, Hachiya T, Bubb RS, Ro JY, Langford L, Sawaya R, Putnam JB, Allen P, Cox JD, McDonnell TJ, Brock W, Hong WK, Roth JA, Milas L. Epidermal growth factor receptor, cyclooxygenase-2, and BAX expression in the primary non-small cell lung cancer and brain metastases. Clin Cancer Res. 2003 Mar; 9(3):1070-6. PMID: 12631609.
      Citations: 13     Fields:    Translation:Humans
    66. Rassidakis GZ, Claret FX, Lai R, Zhang Q, Sarris AH, McDonnell TJ, Medeiros LJ. Expression of p27(Kip1) and c-Jun activation binding protein 1 are inversely correlated in systemic anaplastic large cell lymphoma. Clin Cancer Res. 2003 Mar; 9(3):1121-8. PMID: 12631617.
      Citations: 22     Fields:    Translation:HumansCells
    67. DuHadaway JB, Lynch FJ, Brisbay S, Bueso-Ramos C, Troncoso P, McDonnell T, Prendergast GC. Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: diverse sites of nuclear expression and losses in prostate cancer. J Cell Biochem. 2003 Feb 15; 88(3):635-42. PMID: 12532338.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    68. Swisher SG, Roth JA, Komaki R, Gu J, Lee JJ, Hicks M, Ro JY, Hong WK, Merritt JA, Ahrar K, Atkinson NE, Correa AM, Dolormente M, Dreiling L, El-Naggar AK, Fossella F, Francisco R, Glisson B, Grammer S, Herbst R, Huaringa A, Kemp B, Khuri FR, Kurie JM, Liao Z, McDonnell TJ, Morice R, Morello F, Munden R, Papadimitrakopoulou V, Pisters KM, Putnam JB, Sarabia AJ, Shelton T, Stevens C, Shin DM, Smythe WR, Vaporciyan AA, Walsh GL, Yin M. Induction of p53-regulated genes and tumor regression in lung cancer patients after intratumoral delivery of adenoviral p53 (INGN 201) and radiation therapy. Clin Cancer Res. 2003 Jan; 9(1):93-101. PMID: 12538456.
      Citations: 43     Fields:    Translation:HumansCellsCTClinical Trials
    69. Khoury JD, Medeiros LJ, Rassidakis GZ, McDonnell TJ, Abruzzo LV, Lai R. Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpression. J Pathol. 2003 Jan; 199(1):90-7. PMID: 12474231.
      Citations: 39     Fields:    Translation:HumansCells
    70. Lai R, Rassidakis GZ, Medeiros LJ, Leventaki V, Keating M, McDonnell TJ. Expression of STAT3 and its phosphorylated forms in mantle cell lymphoma cell lines and tumours. J Pathol. 2003 Jan; 199(1):84-9. PMID: 12474230.
      Citations: 21     Fields:    Translation:HumansCells
    71. Rassidakis GZ, Medeiros LJ, Vassilakopoulos TP, Viviani S, Bonfante V, Nadali G, Herling M, Angelopoulou MK, Giardini R, Chilosi M, Kittas C, McDonnell TJ, Bonadonna G, Gianni AM, Pizzolo G, Pangalis GA, Cabanillas F, Sarris AH. BCL-2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens. Blood. 2002 Dec 01; 100(12):3935-41. PMID: 12433696.
      Citations: 19     Fields:    Translation:HumansCells
    72. Dong QG, Sclabas GM, Fujioka S, Schmidt C, Peng B, Wu T, Tsao MS, Evans DB, Abbruzzese JL, McDonnell TJ, Chiao PJ. The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis. Oncogene. 2002 Sep 19; 21(42):6510-9. PMID: 12226754.
      Citations: 48     Fields:    Translation:HumansCells
    73. Lai R, McDonnell TJ, O'Connor SL, Medeiros LJ, Oudat R, Keating M, Morgan MB, Curiel TJ, Ford RJ. Establishment and characterization of a new mantle cell lymphoma cell line, Mino. Leuk Res. 2002 Sep; 26(9):849-55. PMID: 12127561.
      Citations: 18     Fields:    Translation:HumansCells
    74. Rassidakis GZ, Jones D, Thomaides A, Sen F, Lai R, Cabanillas F, McDonnell TJ, Medeiros LJ. Apoptotic rate in peripheral T-cell lymphomas. A study using a tissue microarray with validation on full tissue sections. Am J Clin Pathol. 2002 Sep; 118(3):328-34. PMID: 12219774.
      Citations: 8     Fields:    Translation:HumansCells
    75. Cho S, O'Connor SL, McDonnell TJ. Evidence that nucleotide excision repair is attenuated in bax-deficient mammalian cells following ultraviolet irradiation. Exp Cell Res. 2002 Aug 15; 278(2):158-65. PMID: 12169271.
      Citations: 1     Fields:    Translation:AnimalsCells
    76. Bubb RS, Komaki R, Hachiya T, Milas I, Ro JY, Langford L, Sawaya R, Putnam JB, Allen P, Cox JD, McDonnell TJ, Brock W, Hong WK, Roth JA, Milas L. Association of Ki-67, p53, and bcl-2 expression of the primary non-small-cell lung cancer lesion with brain metastatic lesion. Int J Radiat Oncol Biol Phys. 2002 Aug 01; 53(5):1216-24. PMID: 12128123.
      Citations: 10     Fields:    Translation:Humans
    77. Rassidakis GZ, Lai R, McDonnell TJ, Cabanillas F, Sarris AH, Medeiros LJ. Overexpression of Mcl-1 in anaplastic large cell lymphoma cell lines and tumors. Am J Pathol. 2002 Jun; 160(6):2309-10. PMID: 12057933.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    78. Munshi A, McDonnell TJ, Meyn RE. Chemotherapeutic agents enhance TRAIL-induced apoptosis in prostate cancer cells. Cancer Chemother Pharmacol. 2002 Jul; 50(1):46-52. PMID: 12111111.
      Citations: 16     Fields:    Translation:HumansCells
    79. O'Connor SL, Cho JH, McDonnell TJ. The application of molecular techniques to solid tumors. Semin Diagn Pathol. 2002 May; 19(2):94-103. PMID: 12036284.
      Citations:    Fields:    Translation:HumansCells
    80. Honda T, Kagawa S, Spurgers KB, Gjertsen BT, Roth JA, Fang B, Lowe SL, Norris JS, Meyn RE, McDonnell TJ. A recombinant adenovirus expressing wild-type Bax induces apoptosis in prostate cancer cells independently of their Bcl-2 status and androgen sensitivity. Cancer Biol Ther. 2002 Mar-Apr; 1(2):163-7. PMID: 12170776.
      Citations: 6     Fields:    Translation:HumansCells
    81. Fizazi K, Martinez LA, Sikes CR, Johnston DA, Stephens LC, McDonnell TJ, Logothetis CJ, Trapman J, Pisters LL, Ordoñez NG, Troncoso P, Navone NM. The association of p21((WAF-1/CIP1)) with progression to androgen-independent prostate cancer. Clin Cancer Res. 2002 Mar; 8(3):775-81. PMID: 11895908.
      Citations: 19     Fields:    Translation:HumansAnimals
    82. Rassidakis GZ, Medeiros LJ, McDonnell TJ, Viviani S, Bonfante V, Nadali G, Vassilakopoulos TP, Giardini R, Chilosi M, Kittas C, Gianni AM, Bonadonna G, Pizzolo G, Pangalis GA, Cabanillas F, Sarris AH. BAX expression in Hodgkin and Reed-Sternberg cells of Hodgkin's disease: correlation with clinical outcome. Clin Cancer Res. 2002 Feb; 8(2):488-93. PMID: 11839668.
      Citations: 5     Fields:    Translation:HumansCells
    83. Delehedde M, Lyon M, Vidyasagar R, McDonnell TJ, Fernig DG. Hepatocyte growth factor/scatter factor binds to small heparin-derived oligosaccharides and stimulates the proliferation of human HaCaT keratinocytes. J Biol Chem. 2002 Apr 05; 277(14):12456-62. PMID: 11799124.
      Citations: 12     Fields:    Translation:HumansCells
    84. Coombes KR, Zhang L, Bueso-Ramos C, Brisbay S, Logothetis C, Roth J, Keating MJ, McDonnell TJ. TAD: a web interface and database for tissue microarrays. Appl Bioinformatics. 2002; 1(3):155-8. PMID: 15130842.
      Citations: 4     Fields:    
    85. Kurland JF, Kodym R, Story MD, Spurgers KB, McDonnell TJ, Meyn RE. NF-kappaB1 (p50) homodimers contribute to transcription of the bcl-2 oncogene. J Biol Chem. 2001 Nov 30; 276(48):45380-6. PMID: 11567031.
      Citations: 35     Fields:    Translation:AnimalsCells
    86. Gomez-Manzano C, Mitlianga P, Fueyo J, Lee HY, Hu M, Spurgers KB, Glass TL, Koul D, Liu TJ, McDonnell TJ, Yung WK. Transfer of E2F-1 to human glioma cells results in transcriptional up-regulation of Bcl-2. Cancer Res. 2001 Sep 15; 61(18):6693-7. PMID: 11559537.
      Citations: 25     Fields:    Translation:HumansCells
    87. Lowe SL, Rubinchik S, Honda T, McDonnell TJ, Dong JY, Norris JS. Prostate-specific expression of Bax delivered by an adenoviral vector induces apoptosis in LNCaP prostate cancer cells. Gene Ther. 2001 Sep; 8(18):1363-71. PMID: 11571575.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    88. Honda T, Gjertsen BT, Spurgers KB, Briones F, Lee SJ, Hobbs ML, Meyn RE, Roth JA, Logothetis C, McDonnell TJ. Restoration of bax in prostate cancer suppresses tumor growth and augments therapeutic cell death induction. Anticancer Res. 2001 Sep-Oct; 21(5):3141-6. PMID: 11848465.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    89. Rassidakis GZ, Sarris AH, Herling M, Ford RJ, Cabanillas F, McDonnell TJ, Medeiros LJ. Differential expression of BCL-2 family proteins in ALK-positive and ALK-negative anaplastic large cell lymphoma of T/null-cell lineage. Am J Pathol. 2001 Aug; 159(2):527-35. PMID: 11485911.
      Citations: 23     Fields:    Translation:HumansCells
    90. Munshi A, Pappas G, Honda T, McDonnell TJ, Younes A, Li Y, Meyn RE. TRAIL (APO-2L) induces apoptosis in human prostate cancer cells that is inhibitable by Bcl-2. Oncogene. 2001 Jun 28; 20(29):3757-65. PMID: 11439339.
      Citations: 24     Fields:    Translation:HumansCells
    91. Kagawa S, Gu J, Honda T, McDonnell TJ, Swisher SG, Roth JA, Fang B. Deficiency of caspase-3 in MCF7 cells blocks Bax-mediated nuclear fragmentation but not cell death. Clin Cancer Res. 2001 May; 7(5):1474-80. PMID: 11350920.
      Citations: 39     Fields:    Translation:HumansCells
    92. Delehedde M, Cho SH, Hamm R, Brisbay S, Ananthaswamy HN, Kripke M, McDonnell TJ. Impact of Bcl-2 and Ha-ras on keratinocytes in organotypic culture. J Invest Dermatol. 2001 Mar; 116(3):366-73. PMID: 11231309.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    93. Cho SH, Delehedde M, Rodriguez-Villanueva J, Brisbay S, McDonnell TJ. Bax gene disruption alters the epidermal response to ultraviolet irradiation and in vivo induced skin carcinogenesis. Int J Mol Med. 2001 Mar; 7(3):235-41. PMID: 11179500.
      Citations: 5     Fields:    Translation:AnimalsCells
    94. Fernandez A, Udagawa T, Schwesinger C, Beecken W, Achilles-Gerte E, McDonnell T, D'Amato R. Angiogenic potential of prostate carcinoma cells overexpressing bcl-2. J Natl Cancer Inst. 2001 Feb 07; 93(3):208-13. PMID: 11158189.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    95. Connor MC, O'Shea FD, O'Driscoll MF, Concannon D, McDonnell TJ. Efficacy of pulmonary rehabilitation in an Irish population. Ir Med J. 2001 Feb; 94(2):46-8. PMID: 11321172.
      Citations: 5     Fields:    Translation:HumansCTClinical Trials
    96. Schumacher G, Bruckheimer EM, Beham AW, Honda T, Brisbay S, Roth JA, Logothetis C, McDonnell TJ. Molecular determinants of cell death induction following adenovirus-mediated gene transfer of wild-type p53 in prostate cancer cells. Int J Cancer. 2001 Jan 15; 91(2):159-66. PMID: 11146439.
      Citations: 4     Fields:    Translation:HumansCells
    97. Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg. 2001 Jan; 121(1):61-7. PMID: 11135160.
      Citations: 2     Fields:    Translation:HumansCells
    98. Bruckheimer EM, Brisbay S, Johnson DJ, Gingrich JR, Greenberg N, McDonnell TJ. Bcl-2 accelerates multistep prostate carcinogenesis in vivo. Oncogene. 2000 Nov 02; 19(46):5251-8. PMID: 11077442.
      Citations: 9     Fields:    Translation:Animals
    99. Bruckheimer EM, Cho S, Brisbay S, Johnson DJ, Gingrich JR, Greenberg N, McDonnell TJ. The impact of bcl-2 expression and bax deficiency on prostate homeostasis in vivo. Oncogene. 2000 May 11; 19(20):2404-12. PMID: 10828882.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    100. Liu G, McDonnell TJ, Montes de Oca Luna R, Kapoor M, Mims B, El-Naggar AK, Lozano G. High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4174-9. PMID: 10760284.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    101. Tseng BS, Cavin ST, Booth FW, Olson EN, Marin MC, McDonnell TJ, Butler IJ. Pulmonary hypoplasia in the myogenin null mouse embryo. Am J Respir Cell Mol Biol. 2000 Mar; 22(3):304-15. PMID: 10696067.
      Citations: 9     Fields:    Translation:Animals
    102. Navone NM, Rodriquez-Vargas MC, Benedict WF, Troncoso P, McDonnell TJ, Zhou JH, Luthra R, Logothetis CJ. TabBO: a model reflecting common molecular features of androgen-independent prostate cancer. Clin Cancer Res. 2000 Mar; 6(3):1190-7. PMID: 10741751.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    103. Pearson AS, Spitz FR, Swisher SG, Kataoka M, Sarkiss MG, Meyn RE, McDonnell TJ, Cristiano RJ, Roth JA. Up-regulation of the proapoptotic mediators Bax and Bak after adenovirus-mediated p53 gene transfer in lung cancer cells. Clin Cancer Res. 2000 Mar; 6(3):887-90. PMID: 10741712.
      Citations: 11     Fields:    Translation:HumansCells
    104. Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res. 2000 Feb 15; 60(4):788-92. PMID: 10706081.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    105. Bustamante JO, Michelette ER, Geibel JP, Dean DA, Hanover JA, McDonnell TJ. Calcium, ATP and nuclear pore channel gating. Pflugers Arch. 2000 Feb; 439(4):433-44. PMID: 10678739.
      Citations: 11     Fields:    Translation:AnimalsCells
    106. Fueyo J, Gomez-Manzano C, Alemany R, Lee PS, McDonnell TJ, Mitlianga P, Shi YX, Levin VA, Yung WK, Kyritsis AP. A mutant oncolytic adenovirus targeting the Rb pathway produces anti-glioma effect in vivo. Oncogene. 2000 Jan 06; 19(1):2-12. PMID: 10644974.
      Citations: 238     Fields:    Translation:HumansAnimalsCells
    107. Kagawa S, Pearson SA, Ji L, Xu K, McDonnell TJ, Swisher SG, Roth JA, Fang B. A binary adenoviral vector system for expressing high levels of the proapoptotic gene bax. Gene Ther. 2000 Jan; 7(1):75-9. PMID: 10680019.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    108. Spurgers K, Briones F, McDonnell TJ. Prostate cancer: another piece to the molecular puzzle. Adv Anat Pathol. 2000 Jan; 7(1):9-12. PMID: 10640197.
      Citations:    Fields:    Translation:HumansAnimalsCells
    109. Blutt SE, McDonnell TJ, Polek TC, Weigel NL. Calcitriol-induced apoptosis in LNCaP cells is blocked by overexpression of Bcl-2. Endocrinology. 2000 Jan; 141(1):10-7. PMID: 10614618.
      Citations: 42     Fields:    Translation:HumansCells
    110. Pisters LL, Pettaway CA, Hossan E, Evans R, Steiner MS, Wood CG, Troncoso P, McDonnell TJ, Fenstenmacher MJ, Logothetis CJ. Intraprostatic AD-p53 gene therapy followed by radical prostatectomy: feasibility and preliminary results. Prostate Cancer Prostatic Dis. 1999 Nov; 2(S3):S27. PMID: 12496806.
      Citations: 1     Fields:    
    111. Bruckheimer EM, Gjertsen BT, McDonnell TJ. Implications of cell death regulation in the pathogenesis and treatment of prostate cancer. Semin Oncol. 1999 Aug; 26(4):382-98. PMID: 10482181.
      Citations: 5     Fields:    Translation:Humans
    112. McDonnell TJ, Montes de Oca Luna R, Cho S, Amelse LL, Chavez-Reyes A, Lozano G. Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol. 1999 Jul; 188(3):322-8. PMID: 10419603.
      Citations: 27     Fields:    Translation:Animals
    113. Davies MA, Koul D, Dhesi H, Berman R, McDonnell TJ, McConkey D, Yung WK, Steck PA. Regulation of Akt/PKB activity, cellular growth, and apoptosis in prostate carcinoma cells by MMAC/PTEN. Cancer Res. 1999 Jun 01; 59(11):2551-6. PMID: 10363971.
      Citations: 73     Fields:    Translation:Humans
    114. López-Guillermo A, Cabanillas F, McDonnell TI, McLaughlin P, Smith T, Pugh W, Hagemeister F, Rodríguez MA, Romaguera JE, Younes A, Sarris AH, Preti HA, Lee MS. Correlation of bcl-2 rearrangement with clinical characteristics and outcome in indolent follicular lymphoma. Blood. 1999 May 01; 93(9):3081-7. PMID: 10216105.
      Citations: 11     Fields:    Translation:HumansCells
    115. Logsdon MD, Meyn RE, Besa PC, Pugh WC, Stephens LC, Peters LJ, Milas L, Cox JD, Cabanillas F, Brisbay S, Andersen M, McDonnell TJ. Apoptosis and the Bcl-2 gene family -- patterns of expression and prognostic value in stage I and II follicular center lymphoma. Int J Radiat Oncol Biol Phys. 1999 Apr 01; 44(1):19-29. PMID: 10219790.
      Citations: 4     Fields:    Translation:Humans
    116. Delehedde M, Cho SH, Sarkiss M, Brisbay S, Davies M, El-Naggar AK, McDonnell TJ. Altered expression of bcl-2 family member proteins in nonmelanoma skin cancer. Cancer. 1999 Apr 01; 85(7):1514-22. PMID: 10193941.
      Citations: 8     Fields:    Translation:HumansCells
    117. Herrmann JL, Briones F, Brisbay S, Logothetis CJ, McDonnell TJ. Prostate carcinoma cell death resulting from inhibition of proteasome activity is independent of functional Bcl-2 and p53. Oncogene. 1998 Dec 03; 17(22):2889-99. PMID: 9879995.
      Citations: 15     Fields:    Translation:HumansCells
    118. Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ, Hung MC. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell. 1998 Nov; 2(5):581-91. PMID: 9844631.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    119. Tormo M, Tari AM, McDonnell TJ, Cabanillas F, Garcia-Conde J, Lopez-Berestein G. Apoptotic induction in transformed follicular lymphoma cells by Bcl-2 downregulation. Leuk Lymphoma. 1998 Jul; 30(3-4):367-79. PMID: 9713967.
      Citations: 4     Fields:    Translation:HumansCells
    120. Beham AW, Sarkiss M, Brisbay S, Tu SM, von Eschenbach AC, McDonnell TJ. Molecular correlates of bcl-2-enhanced growth following androgen-ablation in prostate carcinoma cells in vivo. Int J Mol Med. 1998 Jun; 1(6):953-9. PMID: 9852630.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    121. Fueyo J, Gomez-Manzano C, Yung WK, Liu TJ, Alemany R, McDonnell TJ, Shi X, Rao JS, Levin VA, Kyritsis AP. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med. 1998 Jun; 4(6):685-90. PMID: 9623977.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    122. Donnellan P, Armstrong J, Rowan S, Fennelly D, Lynch V, McDonnell T, McNicholas W, Crown J. New chemotherapy combinations with docetaxel in the treatment of patients with non-small cell lung cancer. Semin Oncol. 1998 Jun; 25(3 Suppl 8):20-3. PMID: 9704672.
      Citations: 1     Fields:    Translation:HumansCTClinical Trials
    123. Voehringer DW, McConkey DJ, McDonnell TJ, Brisbay S, Meyn RE. Bcl-2 expression causes redistribution of glutathione to the nucleus. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2956-60. PMID: 9501197.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    124. Rodríguez-Villanueva J, Greenhalgh D, Wang XJ, Bundman D, Cho S, Delehedde M, Roop D, McDonnell TJ. Human keratin-1.bcl-2 transgenic mice aberrantly express keratin 6, exhibit reduced sensitivity to keratinocyte cell death induction, and are susceptible to skin tumor formation. Oncogene. 1998 Feb 19; 16(7):853-63. PMID: 9484776.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    125. Bruckheimer EM, Cho SH, Sarkiss M, Herrmann J, McDonnell TJ. The Bcl-2 gene family and apoptosis. Adv Biochem Eng Biotechnol. 1998; 62:75-105. PMID: 9755641.
      Citations: 17     Fields:    Translation:HumansAnimals
    126. Gjertsen BT, Logothetis CJ, McDonnell TJ. Molecular regulation of cell death and therapeutic strategies for cell death induction in prostate carcinoma. Cancer Metastasis Rev. 1998-1999; 17(4):345-51. PMID: 10453278.
      Citations: 5     Fields:    Translation:Humans
    127. Beham A, Schumacher G, McDonnell TJ, Marin MC, Jauch KW. [Bcl-2 inhibits p53-induced apoptosis after genotoxic damage by inhibitors of nuclear import of p53]. Langenbecks Arch Chir Suppl Kongressbd. 1998; 115(Suppl I):113-7. PMID: 14518224.
      Citations:    Fields:    Translation:HumansCells
    128. Beham A, Marin MC, Fernandez A, Herrmann J, Brisbay S, Tari AM, Lopez-Berestein G, Lozano G, Sarkiss M, McDonnell TJ. Bcl-2 inhibits p53 nuclear import following DNA damage. Oncogene. 1997 Dec 04; 15(23):2767-72. PMID: 9419967.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    129. Herrmann JL, Beham AW, Sarkiss M, Chiao PJ, Rands MT, Bruckheimer EM, Brisbay S, McDonnell TJ. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Exp Cell Res. 1997 Nov 25; 237(1):101-9. PMID: 9417872.
      Citations: 22     Fields:    Translation:HumansCells
    130. Pollack A, Wu CS, Czerniak B, Zagars GK, Benedict WF, McDonnell TJ. Abnormal bcl-2 and pRb expression are independent correlates of radiation response in muscle-invasive bladder cancer. Clin Cancer Res. 1997 Oct; 3(10):1823-9. PMID: 9815569.
      Citations: 11     Fields:    Translation:Humans
    131. Mirkovic N, Voehringer DW, Story MD, McConkey DJ, McDonnell TJ, Meyn RE. Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols. Oncogene. 1997 Sep 18; 15(12):1461-70. PMID: 9333022.
      Citations: 35     Fields:    Translation:AnimalsCells
    132. Hewitt SM, Hamada S, Monarres A, Kottical LV, Saunders GF, McDonnell TJ. Transcriptional activation of the bcl-2 apoptosis suppressor gene by the paired box transcription factor PAX8. Anticancer Res. 1997 Sep-Oct; 17(5A):3211-5. PMID: 9413150.
      Citations: 7     Fields:    Translation:HumansCells
    133. Herrmann JL, Menter DG, Beham A, von Eschenbach A, McDonnell TJ. Regulation of lipid signaling pathways for cell survival and apoptosis by bcl-2 in prostate carcinoma cells. Exp Cell Res. 1997 Aug 01; 234(2):442-51. PMID: 9260915.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    134. Gomez-Manzano C, Fueyo J, Kyritsis AP, McDonnell TJ, Steck PA, Levin VA, Yung WK. Characterization of p53 and p21 functional interactions in glioma cells en route to apoptosis. J Natl Cancer Inst. 1997 Jul 16; 89(14):1036-44. PMID: 9230885.
      Citations: 38     Fields:    Translation:HumansCells
    135. Bruel A, Karsenty E, Schmid M, McDonnell TJ, Lanotte M. Altered sensitivity to retinoid-induced apoptosis associated with changes in the subcellular distribution of Bcl-2. Exp Cell Res. 1997 Jun 15; 233(2):281-7. PMID: 9194490.
      Citations: 6     Fields:    Translation:HumansCells
    136. McDonnell TJ, Navone NM, Troncoso P, Pisters LL, Conti C, von Eschenbach AC, Brisbay S, Logothetis CJ. Expression of bcl-2 oncoprotein and p53 protein accumulation in bone marrow metastases of androgen independent prostate cancer. J Urol. 1997 Feb; 157(2):569-74. PMID: 8996359.
      Citations: 18     Fields:    Translation:Humans
    137. Westin P, Lo P, Marin M, Fernandez A, Sarkiss M, Tu S, Brisbay S, Voneschenbach A, McDonnell T. bcl-2 expression confers androgen independence in androgen sensitive prostatic carcinoma. Int J Oncol. 1997 Jan; 10(1):113-8. PMID: 21533353.
      Citations:    Fields:    
    138. Sinicrope FA, Roddey G, McDonnell TJ, Shen Y, Cleary KR, Stephens LC. Increased apoptosis accompanies neoplastic development in the human colorectum. Clin Cancer Res. 1996 Dec; 2(12):1999-2006. PMID: 9816159.
      Citations: 22     Fields:    Translation:Humans
    139. Herrmann JL, Bruckheimer E, McDonnell TJ. Cell death signal transduction and Bcl-2 function. Biochem Soc Trans. 1996 Nov; 24(4):1059-65. PMID: 8968512.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    140. McDonnell TJ, Beham A, Sarkiss M, Andersen MM, Lo P. Importance of the Bcl-2 family in cell death regulation. Experientia. 1996 Oct 31; 52(10-11):1008-17. PMID: 8917732.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    141. Xie K, Huang S, Wang Y, Beltran PJ, Juang SH, Dong Z, Reed JC, McDonnell TJ, McConkey DJ, Fidler IJ. Bcl-2 protects cells from cytokine-induced nitric-oxide-dependent apoptosis. Cancer Immunol Immunother. 1996 Oct; 43(2):109-15. PMID: 8954145.
      Citations: 2     Fields:    Translation:AnimalsCells
    142. Roth JA, Nguyen D, Lawrence DD, Kemp BL, Carrasco CH, Ferson DZ, Hong WK, Komaki R, Lee JJ, Nesbitt JC, Pisters KM, Putnam JB, Schea R, Shin DM, Walsh GL, Dolormente MM, Han CI, Martin FD, Yen N, Xu K, Stephens LC, McDonnell TJ, Mukhopadhyay T, Cai D. Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer. Nat Med. 1996 Sep; 2(9):985-91. PMID: 8782455.
      Citations: 95     Fields:    Translation:HumansCellsCTClinical Trials
    143. Sastry KJ, Marin MC, Nehete PN, McConnell K, el-Naggar AK, McDonnell TJ. Expression of human immunodeficiency virus type I tat results in down-regulation of bcl-2 and induction of apoptosis in hematopoietic cells. Oncogene. 1996 Aug 01; 13(3):487-93. PMID: 8760290.
      Citations: 35     Fields:    Translation:HumansCells
    144. Marin MC, Fernandez A, Bick RJ, Brisbay S, Buja LM, Snuggs M, McConkey DJ, von Eschenbach AC, Keating MJ, McDonnell TJ. Apoptosis suppression by bcl-2 is correlated with the regulation of nuclear and cytosolic Ca2+. Oncogene. 1996 Jun 06; 12(11):2259-66. PMID: 8649765.
      Citations: 24     Fields:    Translation:AnimalsCells
    145. Steck K, McDonnell T, Sneige N, el-Naggar A. Flow cytometric analysis of apoptosis and bcl-2 in primary breast carcinomas: clinical and biological implications. Cytometry. 1996 Jun 01; 24(2):116-22. PMID: 8725660.
      Citations: 1     Fields:    Translation:HumansCells
    146. McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M. Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol. 1996 Apr 01; 156(7):2624-30. PMID: 8786328.
      Citations: 16     Fields:    Translation:Humans
    147. Sanchez Y, Lovell M, Marin MC, Wong PE, Wolf-Ledbetter ME, McDonnell TJ, Killary AM. Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2551-6. PMID: 8637912.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    148. Robertson LE, Plunkett W, McConnell K, Keating MJ, McDonnell TJ. Bcl-2 expression in chronic lymphocytic leukemia and its correlation with the induction of apoptosis and clinical outcome. Leukemia. 1996 Mar; 10(3):456-9. PMID: 8642861.
      Citations: 76     Fields:    Translation:HumansCells
    149. Gomez-Manzano C, Fueyo J, Kyritsis AP, Steck PA, Roth JA, McDonnell TJ, Steck KD, Levin VA, Yung WK. Adenovirus-mediated transfer of the p53 gene produces rapid and generalized death of human glioma cells via apoptosis. Cancer Res. 1996 Feb 15; 56(4):694-9. PMID: 8630997.
      Citations: 46     Fields:    Translation:HumansCells
    150. Hewitt SM, Hamada S, McDonnell TJ, Rauscher FJ, Saunders GF. Regulation of the proto-oncogenes bcl-2 and c-myc by the Wilms' tumor suppressor gene WT1. Cancer Res. 1995 Nov 15; 55(22):5386-9. PMID: 7585606.
      Citations: 60     Fields:    Translation:HumansCells
    151. Hsu B, Marin MC, McDonnell TJ. Cell death regulation during multistep lymphomagenesis. Cancer Lett. 1995 Jul 20; 94(1):17-23. PMID: 7621440.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    152. Liu TJ, el-Naggar AK, McDonnell TJ, Steck KD, Wang M, Taylor DL, Clayman GL. Apoptosis induction mediated by wild-type p53 adenoviral gene transfer in squamous cell carcinoma of the head and neck. Cancer Res. 1995 Jul 15; 55(14):3117-22. PMID: 7606733.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    153. Tu SM, McConnell K, Marin MC, Campbell ML, Fernandez A, von Eschenbach AC, McDonnell TJ. Combination adriamycin and suramin induces apoptosis in bcl-2 expressing prostate carcinoma cells. Cancer Lett. 1995 Jul 13; 93(2):147-55. PMID: 7621422.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    154. Hsu B, Marin MC, el-Naggar AK, Stephens LC, Brisbay S, McDonnell TJ. Evidence that c-myc mediated apoptosis does not require wild-type p53 during lymphomagenesis. Oncogene. 1995 Jul 06; 11(1):175-9. PMID: 7624125.
      Citations: 29     Fields:    Translation:AnimalsCells
    155. Rodriguez-Villanueva J, Colome MI, Brisbay S, McDonnell TJ. The expression and localization of bcl-2 protein in normal skin and in non-melanoma skin cancers. Pathol Res Pract. 1995 Jun; 191(5):391-8. PMID: 7479356.
      Citations: 5     Fields:    Translation:Humans
    156. Steck KD, McDonnell TJ, el-Naggar AK. Flow cytometric analysis of apoptosis and bcl-2 in human solid neoplasms. Cytometry. 1995 Jun 01; 20(2):154-61. PMID: 7664626.
      Citations: 2     Fields:    Translation:HumansCells
    157. Marin MC, Hsu B, Stephens LC, Brisbay S, McDonnell TJ. The functional basis of c-myc and bcl-2 complementation during multistep lymphomagenesis in vivo. Exp Cell Res. 1995 Apr; 217(2):240-7. PMID: 7698223.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    158. Rodríguez-Villanueva J, McDonnell TJ. Induction of apoptotic cell death in non-melanoma skin cancer by interferon-alpha. Int J Cancer. 1995 Mar 29; 61(1):110-4. PMID: 7705922.
      Citations: 15     Fields:    Translation:HumansCells
    159. Fernandez A, Fosdick LJ, Marin MC, Diaz C, McDonnell TJ, Ananthaswamy HN, McConkey DJ. Differential regulation of endogenous endonuclease activation in isolated murine fibroblast nuclei by ras and bcl-2. Oncogene. 1995 Feb 16; 10(4):769-74. PMID: 7862455.
      Citations: 5     Fields:    Translation:AnimalsCells
    160. McDonnell TJ, Meyn RE, Robertson LE. Implications of apoptotic cell death regulation in cancer therapy. Semin Cancer Biol. 1995 Feb; 6(1):53-60. PMID: 7548842.
      Citations: 7     Fields:    Translation:HumansAnimals
    161. Marin MC, Hsu B, Meyn RE, Donehower LA, el-Naggar AK, McDonnell TJ. Evidence that p53 and bcl-2 are regulators of a common cell death pathway important for in vivo lymphomagenesis. Oncogene. 1994 Nov; 9(11):3107-12. PMID: 7936633.
      Citations: 12     Fields:    Translation:AnimalsCells
    162. Chandler D, el-Naggar AK, Brisbay S, Redline RW, McDonnell TJ. Apoptosis and expression of the bcl-2 proto-oncogene in the fetal and adult human kidney: evidence for the contribution of bcl-2 expression to renal carcinogenesis. Hum Pathol. 1994 Aug; 25(8):789-96. PMID: 7520019.
      Citations: 12     Fields:    Translation:Humans
    163. Fernandez A, Marin MC, McDonnell T, Ananthaswamy HN. Differential sensitivity of normal and Ha-ras-transformed C3H mouse embryo fibroblasts to tumor necrosis factor: induction of bcl-2, c-myc, and manganese superoxide dismutase in resistant cells. Oncogene. 1994 Jul; 9(7):2009-17. PMID: 8208546.
      Citations: 10     Fields:    Translation:AnimalsCells
    164. Nataraj A, Pathak S, Hopwood V, McDonnell T, Ananthaswamy H. Bcl-2 oncogene blocks differentiation and extends viability but does not immortalize normal human keratinocytes. Int J Oncol. 1994 Jun; 4(6):1211-8. PMID: 21567039.
      Citations: 3     Fields:    
    165. McDonnell TJ, Marin MC, Hsu B, Brisbay SM, McConnell K, Tu SM, Campbell ML, Rodriguez-Villanueva J. The bcl-2 oncogene: apoptosis and neoplasia. Radiat Res. 1993 Dec; 136(3):307-12. PMID: 8278571.
      Citations: 6     Fields:    Translation:HumansAnimals
    166. McDonnell TJ. Cell division versus cell death: a functional model of multistep neoplasia. Mol Carcinog. 1993; 8(4):209-13. PMID: 8280368.
      Citations: 8     Fields:    Translation:HumansAnimals
    167. McDonnell TJ, Troncoso P, Brisbay SM, Logothetis C, Chung LW, Hsieh JT, Tu SM, Campbell ML. Expression of the protooncogene bcl-2 in the prostate and its association with emergence of androgen-independent prostate cancer. Cancer Res. 1992 Dec 15; 52(24):6940-4. PMID: 1458483.
      Citations: 218     Fields:    Translation:Animals
    168. Nuñez G, Hockenbery D, McDonnell TJ, Sorensen CM, Korsmeyer SJ. Bcl-2 maintains B cell memory. Nature. 1991 Sep 05; 353(6339):71-3. PMID: 1908951.
      Citations: 36     Fields:    Translation:AnimalsCellsPHPublic Health
    169. McDonnell TJ, Korsmeyer SJ. Progression from lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenic for the t(14; 18). Nature. 1991 Jan 17; 349(6306):254-6. PMID: 1987477.
      Citations: 183     Fields:    Translation:HumansAnimals
    170. McDonnell TJ, Nunez G, Platt FM, Hockenberry D, London L, McKearn JP, Korsmeyer SJ. Deregulated Bcl-2-immunoglobulin transgene expands a resting but responsive immunoglobulin M and D-expressing B-cell population. Mol Cell Biol. 1990 May; 10(5):1901-7. PMID: 2183011.
      Citations: 49     Fields:    Translation:AnimalsCells
    171. Korsmeyer SJ, McDonnell TJ, Nunez G, Hockenbery D, Young R. Bcl-2: B cell life, death and neoplasia. Curr Top Microbiol Immunol. 1990; 166:203-7. PMID: 2073800.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    172. McDonnell TJ, Deane N, Platt FM, Nunez G, Jaeger U, McKearn JP, Korsmeyer SJ. bcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell. 1989 Apr 07; 57(1):79-88. PMID: 2649247.
      Citations: 284     Fields:    Translation:AnimalsCells
    173. Mansi JL, Berger U, McDonnell T, Pople A, Rayter Z, Gazet JC, Coombes RC. The fate of bone marrow micrometastases in patients with primary breast cancer. J Clin Oncol. 1989 Apr; 7(4):445-9. PMID: 2926469.
      Citations: 18     Fields:    Translation:Humans
    174. McDonnell T, Kyriakos M, Roper C, Mazoujian G. Malignant fibrous histiocytoma of the lung. Cancer. 1988 Jan 01; 61(1):137-45. PMID: 2825958.
      Citations: 7     Fields:    Translation:Humans
    175. Mansi JL, Berger U, Easton D, McDonnell T, Redding WH, Gazet JC, McKinna A, Powles TJ, Coombes RC. Micrometastases in bone marrow in patients with primary breast cancer: evaluation as an early predictor of bone metastases. Br Med J (Clin Res Ed). 1987 Oct 31; 295(6606):1093-6. PMID: 3120893.
      Citations: 28     Fields:    Translation:Humans
    176. The clinical relevance and assessment of apoptotic cell death. Advances in Anatomic Pathology. 3:205-211.
    177. Differential PAX5 levels promote malignant B-cell infiltration, progression and drug resistance, and predict a poor prognosis in MCL patients independent of CCND1. Leukemia. 30:580-593.
    178. Chromosomal translocations in leukemia and lymphoma. Cancer Bulletin. 46:264-273.
    179. bcl-2 Oncogene blocks differentiation and extends viability but does not immortalize normal human keratinocytes. International Journal of Oncology. 4:1211-1218.
    180. Clinical and prognostic significance of 3q26.2 and other chromosome 3 abnormalities in CML in the era of tyrosine kinase inhibitors. Blood. 126:1699-1706.
    181. Regulation of cell death during multistep carcinogenesis. Biochemical Society Transactions. 24.
    182. Corrigendum. Cancer Letters. 99:247.
    183. Erratum. Oncogene. 19:5038.
    184. Intraprostatic AD-p53 gene therapy followed by radical prostatectomy. Prostate Cancer and Prostatic Diseases. 2.
    185. ATF4 induction through an atypical integrated stress response to ONC201 triggers p53-independent apoptosis in hematological malignancies. Science Signaling. 9.
    186. The ultrastructure of the atrium in the adult newt Notophthalmus viridescens (Amphibia, Salamandridae). Journal of Morphology. 175:235-251.
    187. Clinical features, tumor biology, and prognosis associated with MYC rearrangement and Myc overexpression in diffuse large B-cell lymphoma patients treated with rituximab-CHOP. Modern Pathology. 28:1555-1573.
    188. Expression of bcl-2 and its correlation with the development of androgen independent. Cancer Bulletin. 45:448-452.
    189. Donor-derived T-cell large granular lymphocytic leukemia in a patient with peripheral T-cell lymphoma. JNCCN Journal of the National Comprehensive Cancer Network. 14:939-944.
    190. Apoptotic pathways in prostate cancer progression. Cancer Research Therapy and Control. 7:207-209.
    191. Insights into the pathogenesis of follicular lymphoma gained from the bcl-2-immunoglobulin transgenic mouse. Clinical Immunology Newsletter. 14:52-56.
    192. Expression of bcl-2 gene confers multidrug resistance to chemotherapy- induced cell death. Cancer Bulletin. 46:125-129.
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