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WILLIAM H KLEIN

TitleProfessor
InstitutionMD Anderson
DepartmentSystems Biology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Berrigan D, Dean D, Senft Everson N, D'Angelo H, Boyd P, Klein WMP, Han PKJ. Uncertainty: a neglected determinant of health behavior? Front Psychol. 2023; 14:1145879. PMID: 37251060; PMCID: PMC10213393.
      Citations:    
    2. Packard A, Klein WH, Costantini F. Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formation. Development. 2021 05 01; 148(9). PMID: 33914865; PMCID: PMC8214802.
      Citations: 1     Fields:    Translation:AnimalsCells
    3. Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD. Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability. Neuropathol Appl Neurobiol. 2021 06; 47(4):488-505. PMID: 33119191.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    4. Zullo JM, Drake D, Aron L, O'Hern P, Dhamne SC, Davidsohn N, Mao CA, Klein WH, Rotenberg A, Bennett DA, Church GM, Yankner BA, Colai?covo MP. Regulation of lifespan by neural excitation and REST. Nature. 2019 10; 574(7778):359-364. PMID: 31619788; PMCID: PMC6893853.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    5. Kiyama T, Long Y, Chen CK, Whitaker CM, Shay A, Wu H, Badea TC, Mohsenin A, Parker-Thornburg J, Klein WH, Mills SL, Massey SC, Mao CA. Essential Roles of Tbr1 in the Formation and Maintenance of the Orientation-Selective J-RGCs and a Group of OFF-Sustained RGCs in Mouse. Cell Rep. 2019 04 16; 27(3):900-915.e5. PMID: 30995485; PMCID: PMC6542366.
      Citations: 5     Fields:    Translation:AnimalsCells
    6. Turbitt E, Roberts MC, Taber JM, Waters EA, McNeel TS, Biesecker BB, Klein WMP. Genetic counseling, genetic testing, and risk perceptions for breast and colorectal cancer: Results from the 2015 National Health Interview Survey. Prev Med. 2019 06; 123:12-19. PMID: 30817954; PMCID: PMC7321923.
      Citations: 3     Fields:    Translation:Humans
    7. Kiyama T, Chen CK, Wang SW, Pan P, Ju Z, Wang J, Takada S, Klein WH, Mao CA. Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 10 17; 13(1):56. PMID: 30333037; PMCID: PMC6192121.
      Citations: 26     Fields:    Translation:AnimalsCells
    8. Kaufman AR, Dwyer LA, Land SR, Klein WMP, Park ER. Smoking-related health beliefs and smoking behavior in the National Lung Screening Trial. Addict Behav. 2018 09; 84:27-32. PMID: 29605757; PMCID: PMC6101245.
      Citations: 1     Fields:    Translation:Humans
    9. Ferrer RA, Klein WMP, Avishai A, Jones K, Villegas M, Sheeran P. When does risk perception predict protection motivation for health threats? A person-by-situation analysis. PLoS One. 2018; 13(3):e0191994. PMID: 29494705; PMCID: PMC5832213.
      Citations: 23     Fields:    Translation:Humans
    10. Zhang Q, Zagozewski J, Cheng S, Dixit R, Zhang S, de Melo J, Mu X, Klein WH, Brown NL, Wigle JT, Schuurmans C, Eisenstat DD. Regulation of Brn3b by DLX1 and DLX2 is required for retinal ganglion cell differentiation in the vertebrate retina. Development. 2017 05 01; 144(9):1698-1711. PMID: 28356311; PMCID: PMC5450843.
      Citations: 14     Fields:    Translation:AnimalsCells
    11. DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL. Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station. Yale J Biol Med. 2017 03; 90(1):45-61. PMID: 28356893; PMCID: PMC5369044.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    12. Yin J, Zhao F, Chojnacki JE, Fulp J, Klein WL, Zhang S, Zhu X. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2018 03; 55(3):1977-1987. PMID: 28255908; PMCID: PMC5585057.
      Citations: 56     Fields:    Translation:Animals
    13. Mao CA, Agca C, Mocko-Strand JA, Wang J, Pan P, Wang SW, Arnone MI, Frishman LJ, Klein WH, Ullrich-L?ter E. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proc Biol Sci. 2016 Mar 16; 283(1826):20152978. PMID: 26962139; PMCID: PMC4810862.
      Citations: 2     Fields:    Translation:AnimalsCells
    14. Knight EM, Ruiz HH, Kim SH, Harte JC, Hsieh W, Glabe C, Klein WL, Attie AD, Buettner C, Ehrlich ME, Gandy S. Unexpected partial correction of metabolic and behavioral phenotypes of Alzheimer's APP/PSEN1 mice by gene targeting of diabetes/Alzheimer's-related Sorcs1. Acta Neuropathol Commun. 2016 Feb 25; 4:16. PMID: 26916443; PMCID: PMC4766719.
      Citations: 8     Fields:    Translation:HumansAnimals
    15. Mao CA, Klein WH, Martinet V, Tonon S, Torres D, Azouz A, Nguyen M, Kohler A, Flamand V, Leo O, Goriely S. Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun. 2015 May 08; 6:7089. PMID: 25953241; PMCID: PMC4432629.
      Citations: 31     Fields:    Translation:AnimalsCells
    16. Gao Z, Mao CA, Pan P, Mu X, Klein WH. Transcriptome of Atoh7 retinal progenitor cells identifies new Atoh7-dependent regulatory genes for retinal ganglion cell formation. Dev Neurobiol. 2014 Nov; 74(11):1123-40. PMID: 24799426; PMCID: PMC4183711.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    17. Ehrman LA, Mu X, Waclaw RR, Yoshida Y, Vorhees CV, Klein WH, Campbell K. The LIM homeobox gene Isl1 is required for the correct development of the striatonigral pathway in the mouse. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):E4026-35. PMID: 24082127; PMCID: PMC3801072.
      Citations: 41     Fields:    Translation:AnimalsCells
    18. Nowotschin S, Costello I, Piliszek A, Kwon GS, Mao CA, Klein WH, Robertson EJ, Hadjantonakis AK. The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo. Genes Dev. 2013 May 01; 27(9):997-1002. PMID: 23651855; PMCID: PMC3656330.
      Citations: 27     Fields:    Translation:AnimalsCells
    19. Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM. Disruption of neocortical histone H3 homeostasis by soluble A?: implications for Alzheimer's disease. Neurobiol Aging. 2013 Sep; 34(9):2081-90. PMID: 23582659.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    20. Wang J, Sun Z, Zhang Z, Saadi I, Wang J, Li X, Gao S, Engle JJ, Kuburas A, Fu X, Yu W, Klein WH, Russo AF, Amendt BA. Protein inhibitors of activated STAT (Pias1 and Piasy) differentially regulate pituitary homeobox 2 (PITX2) transcriptional activity. J Biol Chem. 2013 May 03; 288(18):12580-95. PMID: 23515314; PMCID: PMC3642306.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    21. Mao CA, Cho JH, Wang J, Gao Z, Pan P, Tsai WW, Frishman LJ, Klein WH. Reprogramming amacrine and photoreceptor progenitors into retinal ganglion cells by replacing Neurod1 with Atoh7. Development. 2013 Feb 01; 140(3):541-51. PMID: 23293286; PMCID: PMC3561791.
      Citations: 22     Fields:    Translation:AnimalsCells
    22. Cho JH, Mao CA, Klein WH. Adult mice transplanted with embryonic retinal progenitor cells: new approach for repairing damaged optic nerves. Mol Vis. 2012; 18:2658-72. PMID: 23170059; PMCID: PMC3501281.
      Citations: 12     Fields:    Translation:AnimalsCells
    23. Mandal NA, Tran JT, Saadi A, Rahman AK, Huynh TP, Klein WH, Cho JH. Expression and localization of CERKL in the mammalian retina, its response to light-stress, and relationship with NeuroD1 gene. Exp Eye Res. 2013 Jan; 106:24-33. PMID: 23142158; PMCID: PMC3538916.
      Citations: 11     Fields:    Translation:AnimalsCellsPHPublic Health
    24. Mizuguchi R, Naritsuka H, Mori K, Mao CA, Klein WH, Yoshihara Y. Tbr2 deficiency in mitral and tufted cells disrupts excitatory-inhibitory balance of neural circuitry in the mouse olfactory bulb. J Neurosci. 2012 Jun 27; 32(26):8831-44. PMID: 22745484; PMCID: PMC3700647.
      Citations: 27     Fields:    Translation:AnimalsCells
    25. Zou M, Li S, Klein WH, Xiang M. Brn3a/Pou4f1 regulates dorsal root ganglion sensory neuron specification and axonal projection into the spinal cord. Dev Biol. 2012 Apr 15; 364(2):114-27. PMID: 22326227; PMCID: PMC3299823.
      Citations: 38     Fields:    Translation:AnimalsCells
    26. Ferrer RA, Dillard AJ, Klein WM. Projection, conformity and deviance regulation: a prospective study of alcohol use. Psychol Health. 2012; 27(6):688-703. PMID: 22172018.
      Citations: 8     Fields:    Translation:Humans
    27. Agca C, Elhajj MC, Klein WH, Venuti JM. Neurosensory and neuromuscular organization in tube feet of the sea urchin Strongylocentrotus purpuratus. J Comp Neurol. 2011 Dec 01; 519(17):3566-79. PMID: 21800307.
      Citations: 6     Fields:    Translation:AnimalsCells
    28. Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, Klein WL, Mori H. Intraneuronal amyloid ? oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. J Neurosci Res. 2011 Jul; 89(7):1031-42. PMID: 21488093.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    29. Meadows E, Flynn JM, Klein WH. Myogenin regulates exercise capacity but is dispensable for skeletal muscle regeneration in adult mdx mice. PLoS One. 2011 Jan 14; 6(1):e16184. PMID: 21264243; PMCID: PMC3021523.
      Citations: 15     Fields:    Translation:Animals
    30. Flynn JM, Meadows E, Fiorotto M, Klein WH. Myogenin regulates exercise capacity and skeletal muscle metabolism in the adult mouse. PLoS One. 2010 Oct 22; 5(10):e13535. PMID: 21042574; PMCID: PMC2962629.
      Citations: 22     Fields:    Translation:Animals
    31. Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 01; 349(1):90-9. PMID: 20969844; PMCID: PMC2993882.
      Citations: 16     Fields:    Translation:AnimalsCells
    32. Kiyama T, Mao CA, Cho JH, Fu X, Pan P, Mu X, Klein WH. Overlapping spatiotemporal patterns of regulatory gene expression are required for neuronal progenitors to specify retinal ganglion cell fate. Vision Res. 2011 Jan 28; 51(2):251-9. PMID: 20951721; PMCID: PMC3390162.
      Citations: 18     Fields:    Translation:AnimalsCells
    33. Moresi V, Williams AH, Meadows E, Flynn JM, Potthoff MJ, McAnally J, Shelton JM, Backs J, Klein WH, Richardson JA, Bassel-Duby R, Olson EN. Myogenin and class II HDACs control neurogenic muscle atrophy by inducing E3 ubiquitin ligases. Cell. 2010 Oct 01; 143(1):35-45. PMID: 20887891; PMCID: PMC2982779.
      Citations: 204     Fields:    Translation:Animals
    34. Sessa A, Mao CA, Colasante G, Nini A, Klein WH, Broccoli V. Tbr2-positive intermediate (basal) neuronal progenitors safeguard cerebral cortex expansion by controlling amplification of pallial glutamatergic neurons and attraction of subpallial GABAergic interneurons. Genes Dev. 2010 Aug 15; 24(16):1816-26. PMID: 20713522; PMCID: PMC2922508.
      Citations: 53     Fields:    Translation:AnimalsCells
    35. Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, Mori H. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. J Neurosci. 2010 Apr 07; 30(14):4845-56. PMID: 20371804; PMCID: PMC6632783.
      Citations: 174     Fields:    Translation:HumansAnimalsCells
    36. Fu X, Kiyama T, Li R, Russell M, Klein WH, Mu X. Epitope-tagging Math5 and Pou4f2: new tools to study retinal ganglion cell development in the mouse. Dev Dyn. 2009 Sep; 238(9):2309-17. PMID: 19459208; PMCID: PMC3401478.
      Citations: 21     Fields:    Translation:AnimalsCells
    37. Kiyama T, Zhang J, Liang S, Liang S, Klein WH. Intragenomic evolution of a transcriptional enhancer in the genome of Strongylocentrotus purpuratus. Mar Genomics. 2009 Jun; 2(2):85-98. PMID: 21798176; PMCID: PMC3390921.
      Citations:    Fields:    
    38. Agca C, Klein WH, Venuti JM. Reduced O2 and elevated ROS in sea urchin embryos leads to defects in ectoderm differentiation. Dev Dyn. 2009 Jul; 238(7):1777-87. PMID: 19517573.
      Citations: 3     Fields:    Translation:AnimalsCells
    39. Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Mol Ther. 2009 May; 17(5):803-9. PMID: 19277012; PMCID: PMC2709991.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    40. Agca C, Klein WH, Venuti JM. Respecification of ectoderm and altered Nodal expression in sea urchin embryos after cobalt and nickel treatment. Mech Dev. 2009 May-Jun; 126(5-6):430-42. PMID: 19368800.
      Citations: 3     Fields:    Translation:AnimalsCells
    41. Tang H, Macpherson P, Marvin M, Meadows E, Klein WH, Yang XJ, Goldman D. A histone deacetylase 4/myogenin positive feedback loop coordinates denervation-dependent gene induction and suppression. Mol Biol Cell. 2009 Feb; 20(4):1120-31. PMID: 19109424; PMCID: PMC2642751.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    42. Cho JH, Mu X, Wang SW, Klein WH. Retinal ganglion cell death and optic nerve degeneration by genetic ablation in adult mice. Exp Eye Res. 2009 Mar; 88(3):542-52. PMID: 19109949; PMCID: PMC3398624.
      Citations: 7     Fields:    Translation:AnimalsCells
    43. Sessa A, Mao CA, Hadjantonakis AK, Klein WH, Broccoli V. Tbr2 directs conversion of radial glia into basal precursors and guides neuronal amplification by indirect neurogenesis in the developing neocortex. Neuron. 2008 Oct 09; 60(1):56-69. PMID: 18940588; PMCID: PMC2887762.
      Citations: 202     Fields:    Translation:AnimalsCells
    44. Sirinyan M, Hamel D, Zaniolo K, Cho JH, Kermorvant-Duchemin E, Varma DR, Tremblay S, Leduc M, Rihakova L, Hardy P, Klein WH, Mu X, Mamer O, Lachapelle P, Di Polo A, Andelfinger G, Mitchell G, Sennlaub F, Chemtob S, Sapieha P, Joyal JS, Honor? JC, Beaus?jour C. The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis. Nat Med. 2008 Oct; 14(10):1067-76. PMID: 18836459.
      Citations: 139     Fields:    Translation:AnimalsCells
    45. Mao CA, Wang SW, Pan P, Klein WH. Rewiring the retinal ganglion cell gene regulatory network: Neurod1 promotes retinal ganglion cell fate in the absence of Math5. Development. 2008 Oct; 135(20):3379-88. PMID: 18787067.
      Citations: 25     Fields:    Translation:AnimalsCells
    46. Meadows E, Cho JH, Flynn JM, Klein WH. Myogenin regulates a distinct genetic program in adult muscle stem cells. Dev Biol. 2008 Oct 15; 322(2):406-14. PMID: 18721801.
      Citations: 46     Fields:    Translation:AnimalsCells
    47. Mu X, Fu X, Beremand PD, Thomas TL, Klein WH. Gene regulation logic in retinal ganglion cell development: Isl1 defines a critical branch distinct from but overlapping with Pou4f2. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6942-7. PMID: 18460603; PMCID: PMC2383966.
      Citations: 86     Fields:    Translation:AnimalsCells
    48. Mao CA, Kiyama T, Pan P, Furuta Y, Hadjantonakis AK, Klein WH. Eomesodermin, a target gene of Pou4f2, is required for retinal ganglion cell and optic nerve development in the mouse. Development. 2008 Jan; 135(2):271-80. PMID: 18077589; PMCID: PMC2893890.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    49. Kiyama T, Klein WH. SpGataE, a Strongylocentrotus purpuratus ortholog of mammalian Gata4/5/6: protein expression, interaction with putative target gene spec2a, and identification of friend of Gata factor SpFog1. Dev Genes Evol. 2007 Sep; 217(9):651-63. PMID: 17710433.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Davie JK, Cho JH, Meadows E, Flynn JM, Knapp JR, Klein WH. Target gene selectivity of the myogenic basic helix-loop-helix transcription factor myogenin in embryonic muscle. Dev Biol. 2007 Nov 15; 311(2):650-64. PMID: 17904117.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    51. Rishniw M, Fisher PW, Doran RM, Meadows E, Klein WH, Kotlikoff MI. Smooth muscle persists in the muscularis externa of developing and adult mouse esophagus. J Muscle Res Cell Motil. 2007; 28(2-3):153-65. PMID: 17638088.
      Citations: 10     Fields:    Translation:AnimalsCells
    52. Cho JH, Klein WH, Tsai MJ. Compensational regulation of bHLH transcription factors in the postnatal development of BETA2/NeuroD1-null retina. Mech Dev. 2007 Aug; 124(7-8):543-50. PMID: 17629466; PMCID: PMC4300853.
      Citations: 9     Fields:    Translation:AnimalsCells
    53. Ai D, Fu X, Wang J, Lu MF, Chen L, Baldini A, Klein WH, Martin JF. Canonical Wnt signaling functions in second heart field to promote right ventricular growth. Proc Natl Acad Sci U S A. 2007 May 29; 104(22):9319-24. PMID: 17519332; PMCID: PMC1890492.
      Citations: 91     Fields:    Translation:AnimalsCells
    54. Sea Urchin Genome Sequencing Consortium, Sodergren E, Weinstock GM, Davidson EH, Cameron RA, Gibbs RA, Angerer RC, Angerer LM, Arnone MI, Burgess DR, Burke RD, Coffman JA, Dean M, Elphick MR, Ettensohn CA, Foltz KR, Hamdoun A, Hynes RO, Klein WH, Marzluff W, McClay DR, Morris RL, Mushegian A, Rast JP, Smith LC, Thorndyke MC, Vacquier VD, Wessel GM, Wray G, Zhang L, Elsik CG, Ermolaeva O, Hlavina W, Hofmann G, Kitts P, Landrum MJ, Mackey AJ, Maglott D, Panopoulou G, Poustka AJ, Pruitt K, Sapojnikov V, Song X, Souvorov A, Solovyev V, Wei Z, Whittaker CA, Worley K, Durbin KJ, Shen Y, Fedrigo O, Garfield D, Haygood R, Primus A, Satija R, Severson T, Gonzalez-Garay ML, Jackson AR, Milosavljevic A, Tong M, Killian CE, Livingston BT, Wilt FH, Adams N, Carbonneau S, Cheung R, Cormier P, Cosson B, Croce J, Fernandez-Guerra A, Goel M, Kelkar H, Morales J, Mulner-Lorillon O, Robertson AJ, Goldstone JV, Cole B, Epel D, Gold B, Hahn ME, Howard-Ashby M, Scally M, Stegeman JJ, Allgood EL, Cool J, Judkins KM, McCafferty SS, Musante AM, Obar RA, Rawson AP, Rossetti BJ, Gibbons IR, Hoffman MP, Leone A, Istrail S, Materna SC, Samanta MP, Stolc V, Tongprasit W, Tu Q, Bergeron KF, Brandhorst BP, Whittle J, Berney K, Bottjer DJ, Calestani C, Peterson K, Chow E, Yuan QA, Elhaik E, Graur D, Reese JT, Bosdet I, Heesun S, Marra MA, Schein J, Anderson MK, Brockton V, Buckley KM, Cohen AH, Fugmann SD, Hibino T, Loza-Coll M, Majeske AJ, Messier C, Nair SV, Pancer Z, Terwilliger DP, Agca C, Arboleda E, Chen N, Churcher AM, Humphrey GW, Idris MM, Kiyama T, Liang S, Mellott D, Mu X, Murray G, Olinski RP, Raible F, Rowe M, Taylor JS, Tessmar-Raible K, Wang D, Wilson KH, Yaguchi S, Gaasterland T, Galindo BE, Gunaratne HJ, Juliano C, Kinukawa M, Moy GW, Neill AT, Nomura M, Raisch M, Reade A, Roux MM, Song JL, Su YH, Townley IK, Voronina E, Wong JL, Amore G, Branno M, Brown ER, Cavalieri V, Duloquin L, Flytzanis C, Gache C, Lepage T, Locascio A, Martinez P, Matassi G, Matranga V, Range R, Rizzo F, Beane W, Bradham C, Byrum C, Glenn T, Hussain S, Manning G, Miranda E, Thomason R, Walton K, Wikramanayke A, Wu SY, Xu R, Brown CT, Chen L, Gray RF, Lee PY, Nam J, Oliveri P, Smith J, Muzny D, Bell S, Chacko J, Cree A, Curry S, Davis C, Dinh H, Dugan-Rocha S, Fowler J, Gill R, Hamilton C, Hernandez J, Hines S, Hume J, Jackson L, Jolivet A, Kovar C, Lee S, Lewis L, Miner G, Morgan M, Nazareth LV, Okwuonu G, Parker D, Pu LL, Thorn R, Wright R, Bell? R, Genevi?re AM, Hallb??k F, Duboc V, Lapraz F, R?ttinger E. The genome of the sea urchin Strongylocentrotus purpuratus. Science. 2006 Nov 10; 314(5801):941-52. PMID: 17095691; PMCID: PMC3159423.
      Citations: 405     Fields:    Translation:AnimalsCells
    55. Fu X, Sun H, Klein WH, Mu X. Beta-catenin is essential for lamination but not neurogenesis in mouse retinal development. Dev Biol. 2006 Nov 15; 299(2):424-37. PMID: 16959241; PMCID: PMC3385515.
      Citations: 48     Fields:    Translation:AnimalsCells
    56. Knapp JR, Davie JK, Myer A, Meadows E, Olson EN, Klein WH. Loss of myogenin in postnatal life leads to normal skeletal muscle but reduced body size. Development. 2006 Feb; 133(4):601-10. PMID: 16407395.
      Citations: 52     Fields:    Translation:AnimalsCells
    57. Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. Eur J Neurosci. 2006 Jan; 23(1):251-60. PMID: 16420434.
      Citations: 124     Fields:    Translation:Animals
    58. Villinski JT, Kiyama T, Dayal S, Zhang N, Liang S, Klein WH. Structure, expression, and transcriptional regulation of the Strongylocentrotus franciscanus spec gene family encoding intracellular calcium-binding proteins. Dev Genes Evol. 2005 Aug; 215(8):410-22. PMID: 15871032.
      Citations: 2     Fields:    Translation:AnimalsCells
    59. Mu X, Fu X, Sun H, Beremand PD, Thomas TL, Klein WH. A gene network downstream of transcription factor Math5 regulates retinal progenitor cell competence and ganglion cell fate. Dev Biol. 2005 Apr 15; 280(2):467-81. PMID: 15882586.
      Citations: 69     Fields:    Translation:AnimalsCells
    60. Kiyama T, Zhang N, Dayal S, Yun Lee P, Liang S, Villinski JT, Klein WH. Strongylocentrotus purpuratus transcription factor GATA-E binds to and represses transcription at an Otx-Goosecoid cis-regulatory element within the aboral ectoderm-specific spec2a enhancer. Dev Biol. 2005 Apr 15; 280(2):436-47. PMID: 15882584.
      Citations: 3     Fields:    Translation:AnimalsCells
    61. Mu X, Fu X, Sun H, Liang S, Maeda H, Frishman LJ, Klein WH. Ganglion cells are required for normal progenitor- cell proliferation but not cell-fate determination or patterning in the developing mouse retina. Curr Biol. 2005 Mar 29; 15(6):525-30. PMID: 15797020.
      Citations: 41     Fields:    Translation:AnimalsCells
    62. Martin SE, Mu X, Klein WH. Identification of an N-terminal transcriptional activation domain within Brn3b/POU4f2. Differentiation. 2005 Feb; 73(1):18-27. PMID: 15733064.
      Citations: 3     Fields:    Translation:AnimalsCells
    63. Liang S, Zhao S, Mu X, Thomas T, Klein WH. Novel retinal genes discovered by mining the mouse embryonic RetinalExpress database. Mol Vis. 2004 Oct 08; 10:773-86. PMID: 15496829.
      Citations: 2     Fields:    Translation:Animals
    64. Dayal S, Kiyama T, Villinski JT, Zhang N, Liang S, Klein WH. Creation of cis-regulatory elements during sea urchin evolution by co-option and optimization of a repetitive sequence adjacent to the spec2a gene. Dev Biol. 2004 Sep 15; 273(2):436-53. PMID: 15328024.
      Citations: 9     Fields:    Translation:AnimalsCells
    65. Wikramanayake AH, Peterson R, Chen J, Huang L, Bince JM, McClay DR, Klein WH. Nuclear beta-catenin-dependent Wnt8 signaling in vegetal cells of the early sea urchin embryo regulates gastrulation and differentiation of endoderm and mesodermal cell lineages. Genesis. 2004 Jul; 39(3):194-205. PMID: 15282746.
      Citations: 49     Fields:    Translation:AnimalsCells
    66. Ohtoshi A, Wang SW, Maeda H, Saszik SM, Frishman LJ, Klein WH, Behringer RR. Regulation of retinal cone bipolar cell differentiation and photopic vision by the CVC homeobox gene Vsx1. Curr Biol. 2004 Mar 23; 14(6):530-6. PMID: 15043821.
      Citations: 55     Fields:    Translation:AnimalsCells
    67. Mu X, Beremand PD, Zhao S, Pershad R, Sun H, Scarpa A, Liang S, Thomas TL, Klein WH. Discrete gene sets depend on POU domain transcription factor Brn3b/Brn-3.2/POU4f2 for their expression in the mouse embryonic retina. Development. 2004 Mar; 131(6):1197-210. PMID: 14973295.
      Citations: 63     Fields:    Translation:AnimalsCells
    68. Mu X, Klein WH. A gene regulatory hierarchy for retinal ganglion cell specification and differentiation. Semin Cell Dev Biol. 2004 Feb; 15(1):115-23. PMID: 15036214.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    69. Chang L, Bakhos L, Wang Z, Venton DL, Klein WL. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. J Mol Neurosci. 2003; 20(3):305-13. PMID: 14501013.
      Citations: 34     Fields:    Translation:AnimalsCells
    70. Wang SW, Mu X, Bowers WJ, Klein WH. Retinal ganglion cell differentiation in cultured mouse retinal explants. Methods. 2002 Dec; 28(4):448-56. PMID: 12507463.
      Citations: 14     Fields:    Translation:AnimalsCells
    71. Li X, Bhattacharya C, Dayal S, Maity S, Klein WH. Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor. Differentiation. 2002 May; 70(2-3):109-19. PMID: 12076338.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    72. Wang SW, Mu X, Bowers WJ, Kim DS, Plas DJ, Crair MC, Federoff HJ, Gan L, Klein WH. Brn3b/Brn3c double knockout mice reveal an unsuspected role for Brn3c in retinal ganglion cell axon outgrowth. Development. 2002 Jan; 129(2):467-77. PMID: 11807038.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    73. Lin X, Gan L, Klein WH, Wells D. Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):738-43. PMID: 9703997.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    74. Xiang M, Gan L, Li D, Chen ZY, Zhou L, O'Malley BW, Klein W, Nathans J. Essential role of POU-domain factor Brn-3c in auditory and vestibular hair cell development. Proc Natl Acad Sci U S A. 1997 Aug 19; 94(17):9445-50. PMID: 9256502; PMCID: PMC23217.
      Citations: 126     Fields:    Translation:AnimalsCells
    75. Xiang M, Gan L, Li D, Zhou L, Chen ZY, Wagner D, O'Malley BW, Klein W, Nathans J. Role of the Brn-3 family of POU-domain genes in the development of the auditory/vestibular, somatosensory, and visual systems. Cold Spring Harb Symp Quant Biol. 1997; 62:325-36. PMID: 9598366.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    76. Wikramanayake AH, Klein WH. Multiple signaling events specify ectoderm and pattern the oral-aboral axis in the sea urchin embryo. Development. 1997 Jan; 124(1):13-20. PMID: 9006063.
      Citations: 9     Fields:    Translation:AnimalsCells
    77. Mao CA, Wikramanayake AH, Gan L, Chuang CK, Summers RG, Klein WH. Altering cell fates in sea urchin embryos by overexpressing SpOtx, an orthodenticle-related protein. Development. 1996 May; 122(5):1489-98. PMID: 8625836.
      Citations: 4     Fields:    Translation:AnimalsCells
    78. Klein W, Horlacher R, Boos W. Molecular analysis of treB encoding the Escherichia coli enzyme II specific for trehalose. J Bacteriol. 1995 Jul; 177(14):4043-52. PMID: 7608078; PMCID: PMC177135.
      Citations: 20     Fields:    Translation:Cells
    79. Hasty P, Bradley A, Morris JH, Edmondson DG, Venuti JM, Olson EN, Klein WH. Muscle deficiency and neonatal death in mice with a targeted mutation in the myogenin gene. Nature. 1993 Aug 05; 364(6437):501-6. PMID: 8393145.
      Citations: 402     Fields:    Translation:Animals
    80. Xiang M, Lu SY, Musso M, Karsenty G, Klein WH. A G-string positive cis-regulatory element in the LpS1 promoter binds two distinct nuclear factors distributed non-uniformly in Lytechinus pictus embryos. Development. 1991 Dec; 113(4):1345-55. PMID: 1811948.
      Citations: 11     Fields:    Translation:AnimalsCells
    81. Galau GA, Klein WH, Britten RJ, Davidson EH. Significance of rare m RNA sequences in liver. Arch Biochem Biophys. 1977 Mar; 179(2):584-99. PMID: 851359.
      Citations: 15     Fields:    Translation:AnimalsCells
    82. Klein WH, Murphy W, Attardi G, Britten RJ, Davidson EH. Distribution of repetitive and nonrepetivite sequence transcripts in HeLa mRNA. Proc Natl Acad Sci U S A. 1974 May; 71(5):1785-9. PMID: 4525461; PMCID: PMC388325.
      Citations: 20     Fields:    Translation:HumansCells
    83. Clark JM, Klein WH. In vitro translation of STNV-RNA. Methods Enzymol. 1974; 30:754-61. PMID: 4604593.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Wigand R, Klein W. Properties of adenovirus substituted with iododeoxyuridine. Arch Gesamte Virusforsch. 1974; 45(3):298-300. PMID: 4420298.
      Citations: 2     Fields:    Translation:HumansCells
    85. Klein WH, Clark JM. N-terminal sequence of the eucaryotic in vitro product made upon translation of satellite tobacco necrosis virus ribonucleic acid. Biochemistry. 1973 Apr 10; 12(8):1528-31. PMID: 4699985.
      Citations:    Fields:    Translation:AnimalsCells
    86. Lundquist RE, Lazar JM, Klein WH, Clark JM. Translation of satellite tobacco necrosis virus ribonucleic acid. II. Initiation of in vitro translation in procaryotic and eucaryotic systems. Biochemistry. 1972 May 23; 11(11):2014-9. PMID: 4337485.
      Citations: 4     Fields:    Translation:AnimalsCells
    87. Klein WH, Nolan C, Lazar JM, Clark JM. Translation of satellite tobacco necrosis virus ribonucleic acid. I. Characterization of in vitro procaryotic and eucaryotic translation products. Biochemistry. 1972 May 23; 11(11):2009-14. PMID: 4554894.
      Citations: 10     Fields:    Translation:AnimalsCells
    88. Developmental biology of the retina. Seminars in Cell and Developmental Biology. 15:51.
    89. Erratum. Developmental Biology. 174:453.
    90. Type i interferons regulate eomesodermin expression and the development of unconventional memory CD8 <sup>+</sup> T cells. Nature Communications. 6.
    91. Erratum. Developmental Biology. 210:513.
    92. Erratum. Genesis. 31:95-96.
    93. [29]Spec proteins. Methods. 139:354-363.
    94. Development of the vertebrate retina. Methods. 28:385-386.
    95. Substituting mouse transcription factor Pou4f2 with a sea urchin orthologue restores retinal ganglion cell development. Proceedings of the Royal Society B: Biological Sciences. 283.
    96. Manipulating cell fates in the sea urchin embryo. Invertebrate Reproduction and Development. 31:21-29.
    97. Erratum. Biochemical and Biophysical Research Communications. 260:575.
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