LEE M ELLIS

TitleProfessor
InstitutionMD Anderson
DepartmentSurgical Oncology
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ghosh S, Fan F, Powell RT, Roszik J, Park YS, Stephan C, Sebastian M, Tan L, Sorokin AV, Lorenzi PL, Kopetz S, Ellis LM, Bhattacharya R. Vincristine Enhances the Efficacy of MEK Inhibitors in Preclinical Models of KRAS-mutant Colorectal Cancer. Mol Cancer Ther. 2023 08 01; 22(8):962-975. PMID: 37310170.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    2. Fan F, Ghosh S, Powell R, Roszik J, Park Y, Sobieski M, Sorokin A, Stephan C, Kopetz S, Ellis LM, Bhattacharya R. Combining MEK and SRC inhibitors for treatment of colorectal cancer demonstrate increased efficacy in vitro but not in vivo. PLoS One. 2023; 18(3):e0281063. PMID: 36952536; PMCID: PMC10035898.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Rathore M, Zhang W, Wright M, Bhattacharya R, Fan F, Vaziri-Gohar A, Winter J, Wang Z, Markowitz SD, Willis J, Ellis LM, Wang R. Liver Endothelium Promotes HER3-Mediated Cell Survival in Colorectal Cancer with Wild-Type and Mutant KRAS. Mol Cancer Res. 2022 06 03; 20(6):996-1008. PMID: 35276002; PMCID: PMC9177644.
      Citations:    Fields:    Translation:HumansAnimals
    4. Shen C, Tannenbaum D, Horn R, Rogers J, Eng C, Zhou S, Johnson B, Kopetz S, Morris V, Overman M, Parseghian C, Chang GJ, Lopez-Olivo MA, Kanwal R, Ellis LM, Dasari A. Overall Survival in Phase 3 Clinical Trials and the Surveillance, Epidemiology, and End Results Database in Patients With Metastatic Colorectal Cancer, 1986-2016: A Systematic Review. JAMA Netw Open. 2022 05 02; 5(5):e2213588. PMID: 35608860; PMCID: PMC9131746.
      Citations:    Fields:    Translation:Humans
    5. Fan F, Roszik J, Xia L, Ghosh S, Wang R, Ye X, Hawke D, Ellis LM, Bhattacharya R. Cytospin-A Regulates Colorectal Cancer Cell Division and Migration by Modulating Stability of Microtubules and Actin Filaments. Cancers (Basel). 2022 Apr 14; 14(8). PMID: 35454887; PMCID: PMC9026928.
      Citations:    
    6. Xu J, Liu Y, Liu S, Ou W, White A, Stewart S, Tkaczuk KHR, Ellis LM, Wan J, Lu X, He X. Metformin Bicarbonate-Mediated Efficient RNAi for Precise Targeting of TP53 Deficiency in Colon and Rectal Cancers. Nano Today. 2022 Apr; 43. PMID: 35251293; PMCID: PMC8896823.
      Citations:    
    7. Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X. Author Correction: TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature. 2021 Sep; 597(7875):E6. PMID: 34433970.
      Citations:    Fields:    
    8. Von Hoff DD, Clark GM, Coltman CA, Disis ML, Eckhardt SG, Ellis LM, Foti M, Garrett-Mayer E, Hidalgo M, Hilsenbeck SG, Littlefield JH, LoRusso PM, Lyerly HK, Meropol NJ, Patel JD, Piantadosi S, Post DA, Regan MM, Shyr Y, Tempero MA, Tepper JE, Von Roenn J, Weiner LM, Young DC, Vu NV, G?nen M. A Grant-Based Experiment to Train Clinical Investigators: The AACR/ASCO Methods in Clinical Cancer Research Workshop. Clin Cancer Res. 2021 10 15; 27(20):5472-5481. PMID: 34312215; PMCID: PMC8530870.
      Citations: 1     Fields:    Translation:Humans
    9. Abou-El-Enein M, Angelis A, Appelbaum FR, Andrews NC, Bates SE, Bierman AS, Brenner MK, Cavazzana M, Caligiuri MA, Clevers H, Cooke E, Daley GQ, Dzau VJ, Ellis LM, Fineberg HV, Goldstein LSB, Gottschalk S, Hamburg MA, Ingber DE, Kohn DB, Krainer AR, Maus MV, Marks P, Mummery CL, Pettigrew RI, Rutter JL, Teichmann SA, Terzic A, Urnov FD, Williams DA, Wolchok JD, Lawler M, Turtle CJ, Bauer G, Ioannidis JPA. Evidence generation and reproducibility in cell and gene therapy research: A call to action. Mol Ther Methods Clin Dev. 2021 Sep 10; 22:11-14. PMID: 34377737; PMCID: PMC8322039.
      Citations: 2     
    10. Mendis S, Anand S, Karasinska JM, Dasari A, Unger JM, Gothwal A, Ellis LM, Varadhachary G, Kopetz S, Overman MJ, Raghav K, Loree JM. Sex Representation in Clinical Trials Associated with FDA Cancer Drug Approvals Differs Between Solid and Hematologic Malignancies. Oncologist. 2021 02; 26(2):107-114. PMID: 32960478; PMCID: PMC7873318.
      Citations: 3     Fields:    Translation:Humans
    11. Malakorn S, Ouchi A, Hu CY, Sandhu L, Dasari A, You YN, Kopetz ES, Ellis LM, Chang GJ. Tumor Sidedness, Recurrence, and Survival After Curative Resection of Localized Colon Cancer. Clin Colorectal Cancer. 2021 03; 20(1):e53-e60. PMID: 33004292.
      Citations: 4     Fields:    Translation:Humans
    12. Vega EA, Ellis LM. Comment on "A Roadmap for Aspiring Surgeon-Scientists in Today's Healthcare Environment". Ann Surg. 2019 12; 270(6):e114-e115. PMID: 31021829.
      Citations:    Fields:    Translation:Humans
    13. Ko SY, Lee W, Kenny HA, Dang LH, Ellis LM, Jonasch E, Lengyel E, Naora H. Cancer-derived small extracellular vesicles promote angiogenesis by heparin-bound, bevacizumab-insensitive VEGF, independent of vesicle uptake. Commun Biol. 2019; 2:386. PMID: 31646189; PMCID: PMC6802217.
      Citations: 43     Translation:HumansAnimalsCells
    14. Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 05 15; 146(10):2822-2828. PMID: 31472018; PMCID: PMC7365556.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    15. Loree JM, Anand S, Dasari A, Unger JM, Gothwal A, Ellis LM, Varadhachary G, Kopetz S, Overman MJ, Raghav K. Disparity of Race Reporting and Representation in Clinical Trials Leading to Cancer Drug Approvals From 2008 to 2018. JAMA Oncol. 2019 Oct 01; 5(10):e191870. PMID: 31415071; PMCID: PMC6696743.
      Citations: 67     Fields:    
    16. Al Rabadi L, LeBlanc M, Bucy T, Ellis LM, Hershman DL, Meyskens FL, Taylor L, Blanke CD. Trends in Medical Aid in Dying in Oregon and Washington. JAMA Netw Open. 2019 08 02; 2(8):e198648. PMID: 31397857; PMCID: PMC6692681.
      Citations: 4     Fields:    Translation:Humans
    17. Disis MLN, Ellis LM. Scientific Integrity and Data Accuracy. JAMA Oncol. 2019 May 01; 5(5):745. PMID: 30920610.
      Citations: 1     Fields:    
    18. Huang H, Aladelokun O, Ideta T, Giardina C, Ellis LM, Rosenberg DW. Inhibition of PGE2/EP4 receptor signaling enhances oxaliplatin efficacy in resistant colon cancer cells through modulation of oxidative stress. Sci Rep. 2019 03 20; 9(1):4954. PMID: 30894570; PMCID: PMC6427013.
      Citations: 15     Fields:    Translation:HumansCells
    19. Parseghian CM, Tam AL, Yao J, Ensor J, Ellis LM, Raghav K, Overman MJ. Assessment of Reported Trial Characteristics, Rate of Publication, and Inclusion of Mandatory Biopsies of Research Biopsies in Clinical Trials in Oncology. JAMA Oncol. 2019 03 01; 5(3):402-405. PMID: 30383128; PMCID: PMC6439840.
      Citations: 6     Fields:    Translation:Humans
    20. Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Ellis LM. Endothelial Cells Promote Colorectal Cancer Cell Survival by Activating the HER3-AKT Pathway in a Paracrine Fashion. Mol Cancer Res. 2019 01; 17(1):20-29. PMID: 30131447; PMCID: PMC6318043.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    21. Overman MJ, Ellis LM, Joffe S. Ethics and the Underreporting of Research Biopsy Findings in Clinical Trials. JAMA Oncol. 2018 08 01; 4(8):1041-1042. PMID: 29799989.
      Citations: 2     Fields:    Translation:Humans
    22. Blanke C, Ellis L, Meyskens F. Oregon's Death With Dignity Act-Reply. JAMA Oncol. 2018 05 01; 4(5):748. PMID: 29450455.
      Citations:    Fields:    Translation:Humans
    23. Boulbes DR, Costello T, Baggerly K, Fan F, Wang R, Bhattacharya R, Ye X, Ellis LM. A Survey on Data Reproducibility and the Effect of Publication Process on the Ethical Reporting of Laboratory Research. Clin Cancer Res. 2018 07 15; 24(14):3447-3455. PMID: 29643062; PMCID: PMC6050098.
      Citations: 9     Fields:    Translation:Humans
    24. Fan F, Wang R, Boulbes DR, Zhang H, Watowich SS, Xia L, Ye X, Bhattacharya R, Ellis LM. Macrophage conditioned medium promotes colorectal cancer stem cell phenotype via the hedgehog signaling pathway. PLoS One. 2018; 13(1):e0190070. PMID: 29293549; PMCID: PMC5749743.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Bhattacharya R, Ellis LM. It Is Time to Re-Evaluate the Peer Review Process for Preclinical Research. Bioessays. 2018 Jan; 40(1). PMID: 29226979; PMCID: PMC5789767.
      Citations: 1     Fields:    Translation:Humans
    26. Blanke C, LeBlanc M, Hershman D, Ellis L, Meyskens F. Characterizing 18 Years of the Death With Dignity Act in Oregon. JAMA Oncol. 2017 10 01; 3(10):1403-1406. PMID: 28384683; PMCID: PMC5824315.
      Citations: 11     Fields:    Translation:Humans
    27. Parseghian CM, Raghav K, Wolff RA, Ensor J, Yao J, Ellis LM, Tam AL, Overman MJ. Underreporting of Research Biopsies from Clinical Trials in Oncology. Clin Cancer Res. 2017 Nov 01; 23(21):6450-6457. PMID: 28754815; PMCID: PMC5668146.
      Citations: 4     Fields:    Translation:Humans
    28. Bhattacharya R, Fan F, Wang R, Ye X, Xia L, Boulbes D, Ellis LM. Intracrine VEGF signalling mediates colorectal cancer cell migration and invasion. Br J Cancer. 2017 Sep 05; 117(6):848-855. PMID: 28742793; PMCID: PMC5589988.
      Citations: 29     Fields:    Translation:HumansCells
    29. Wang R, Bhattacharya R, Ye X, Fan F, Boulbes DR, Xia L, Ellis LM. Endothelial cells activate the cancer stem cell-associated NANOGP8 pathway in colorectal cancer cells in a paracrine fashion. Mol Oncol. 2017 08; 11(8):1023-1034. PMID: 28453235; PMCID: PMC5537915.
      Citations: 15     Fields:    Translation:HumansCells
    30. Ye X, Wang R, Bhattacharya R, Boulbes DR, Fan F, Xia L, Adoni H, Ajami NJ, Wong MC, Smith DP, Petrosino JF, Venable S, Qiao W, Baladandayuthapani V, Maru D, Ellis LM. Fusobacterium Nucleatum Subspecies Animalis Influences Proinflammatory Cytokine Expression and Monocyte Activation in Human Colorectal Tumors. Cancer Prev Res (Phila). 2017 Jul; 10(7):398-409. PMID: 28483840.
      Citations: 45     Fields:    Translation:HumansCells
    31. Ellis L, Eisenman R, Hoskin A. MATERNAL ACTIVITY DURING PREGNANCY AND SEXUALLY DIMORPHIC TRAITS IN OFFSPRING. J Biosoc Sci. 2018 Jan; 50(1):114-123. PMID: 28366175.
      Citations:    Fields:    Translation:Humans
    32. Balas EA, Ellis LM. Preclinical data: Three-point plan for reproducibility. Nature. 2017 03 01; 543(7643):40. PMID: 28252077.
      Citations: 1     Fields:    Translation:Humans
    33. Ellis LM, Blanke CD, Kohn EC. Words matter: Restoring respect and dignity when referring to individuals with cancer. Cancer. 2017 07 01; 123(13):2390-2391. PMID: 28182266.
      Citations: 1     Fields:    Translation:Humans
    34. Ellis L, Hoskin A. Familial Depressive Symptoms and Delinquency: Separate Self-Reports From Mothers and Their Offspring. Int J Offender Ther Comp Criminol. 2018 04; 62(5):1201-1215. PMID: 27864531.
      Citations: 1     Fields:    Translation:Humans
    35. Raghav K, Morris V, Tang C, Morelli P, Amin HM, Chen K, Manyam GC, Broom B, Overman MJ, Shaw K, Meric-Bernstam F, Maru D, Menter D, Ellis LM, Eng C, Hong D, Kopetz S. MET amplification in metastatic colorectal cancer: an acquired response to EGFR inhibition, not a de novo phenomenon. Oncotarget. 2016 08 23; 7(34):54627-54631. PMID: 27421137; PMCID: PMC5342368.
      Citations: 23     Fields:    Translation:Humans
    36. Grothey A, Ellis LM. Therapy: Colorectal cancer: how to teach an old drug new tricks. Nat Rev Gastroenterol Hepatol. 2016 07; 13(7):384-5. PMID: 27251212.
      Citations: 1     Fields:    Translation:Humans
    37. Bhattacharya R, Ye XC, Wang R, Ling X, McManus M, Fan F, Boulbes D, Ellis LM. Intracrine VEGF Signaling Mediates the Activity of Prosurvival Pathways in Human Colorectal Cancer Cells. Cancer Res. 2016 05 15; 76(10):3014-24. PMID: 26988990; PMCID: PMC4873444.
      Citations: 25     Fields:    Translation:HumansCells
    38. Ellis L, Skorska MN, Bogaert AF. Handedness, sexual orientation, and somatic markers for prenatal androgens: Are southpaws really that gay? Laterality. 2017 Mar; 22(2):157-180. PMID: 26932806.
      Citations: 4     Fields:    Translation:Humans
    39. Jayson GC, Kerbel R, Ellis LM, Harris AL. Antiangiogenic therapy in oncology: current status and future directions. Lancet. 2016 Jul 30; 388(10043):518-29. PMID: 26853587.
      Citations: 290     Fields:    Translation:HumansCells
    40. Wang R, Ye X, Bhattacharya R, Boulbes DR, Fan F, Xia L, Ellis LM. A Disintegrin and Metalloproteinase Domain 17 Regulates Colorectal Cancer Stem Cells and Chemosensitivity Via Notch1 Signaling. Stem Cells Transl Med. 2016 Mar; 5(3):331-8. PMID: 26744411; PMCID: PMC4807666.
      Citations: 15     Fields:    Translation:HumansCells
    41. Raghav KP, Mahajan S, Yao JC, Hobbs BP, Berry DA, Pentz RD, Tam A, Hong WK, Ellis LM, Abbruzzese J, Overman MJ. From Protocols to Publications: A Study in Selective Reporting of Outcomes in Randomized Trials in Oncology. J Clin Oncol. 2015 Nov 01; 33(31):3583-90. PMID: 26304898; PMCID: PMC4979242.
      Citations: 18     Fields:    Translation:Humans
    42. Camp ER, Ellis LM. CCR 20th Anniversary Commentary: RAS as a Biomarker for EGFR--Targeted Therapy for Colorectal Cancer-From Concept to Practice. Clin Cancer Res. 2015 Aug 15; 21(16):3578-80. PMID: 26275951; PMCID: PMC4538994.
      Citations: 8     Fields:    Translation:Humans
    43. Ellis LM. The erosion of research integrity: the need for culture change. Lancet Oncol. 2015 Jul; 16(7):752-4. PMID: 26149871.
      Citations: 3     Fields:    Translation:Humans
    44. Ye X, Fan F, Bhattacharya R, Bellister S, Boulbes DR, Wang R, Xia L, Ivan C, Zheng X, Calin GA, Wang J, Lu X, Ellis LM. VEGFR-1 Pseudogene Expression and Regulatory Function in Human Colorectal Cancer Cells. Mol Cancer Res. 2015 Sep; 13(9):1274-82. PMID: 26041938; PMCID: PMC4573265.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    45. Liu Y, Zhang X, Han C, Wan G, Huang X, Ivan C, Jiang D, Rodriguez-Aguayo C, Lopez-Berestein G, Rao PH, Maru DM, Pahl A, He X, Sood AK, Ellis LM, Anderl J, Lu X. TP53 loss creates therapeutic vulnerability in?colorectal cancer. Nature. 2015 Apr 30; 520(7549):697-701. PMID: 25901683; PMCID: PMC4417759.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    46. Ellis LM, Blanke CD, Roach N. Losing "Losing the Battle With Cancer". JAMA Oncol. 2015 Apr; 1(1):13-4. PMID: 26182295.
      Citations: 4     Fields:    Translation:Humans
    47. Satelli A, Mitra A, Brownlee Z, Xia X, Bellister S, Overman MJ, Kopetz S, Ellis LM, Meng QH, Li S. Epithelial-mesenchymal transitioned circulating tumor cells capture for detecting tumor progression. Clin Cancer Res. 2015 Feb 15; 21(4):899-906. PMID: 25516888; PMCID: PMC4334736.
      Citations: 113     Fields:    Translation:HumansCells
    48. de Gramont A, Watson S, Ellis LM, Tabernero J, de Gramont A, Hamilton SR, Rod?n J. Pragmatic issues in biomarker evaluation for targeted therapies in cancer. Nat Rev Clin Oncol. 2015 Apr; 12(4):197-212. PMID: 25421275.
      Citations: 62     Fields:    Translation:Humans
    49. Tang C, Hess K, Jardim DL, Gagliato Dde M, Tsimberidou AM, Falchook G, Fu S, Janku F, Naing A, Piha-Paul S, Subbiah V, Wheler J, Zinner RG, Kurzrock R, Ellis LM, Meric-Berstam F, Hong DS. Synergy between VEGF/VEGFR inhibitors and chemotherapy agents in the phase I clinic. Clin Cancer Res. 2014 Dec 01; 20(23):5956-63. PMID: 25316815.
      Citations: 7     Fields:    Translation:HumansCTClinical Trials
    50. Pecot CV, Wu SY, Bellister S, Filant J, Rupaimoole R, Hisamatsu T, Bhattacharya R, Maharaj A, Azam S, Rodriguez-Aguayo C, Nagaraja AS, Morelli MP, Gharpure KM, Waugh TA, Gonzalez-Villasana V, Zand B, Dalton HJ, Kopetz S, Lopez-Berestein G, Ellis LM, Sood AK. Therapeutic silencing of KRAS using systemically delivered siRNAs. Mol Cancer Ther. 2014 Dec; 13(12):2876-85. PMID: 25281617; PMCID: PMC4416486.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    51. Paller CJ, Bradbury PA, Ivy SP, Seymour L, LoRusso PM, Baker L, Rubinstein L, Huang E, Collyar D, Groshen S, Reeves S, Ellis LM, Sargent DJ, Rosner GL, LeBlanc ML, Ratain MJ. Design of phase I combination trials: recommendations of the Clinical Trial Design Task Force of the NCI Investigational Drug Steering Committee. Clin Cancer Res. 2014 Aug 15; 20(16):4210-7. PMID: 25125258; PMCID: PMC4135521.
      Citations: 26     Fields:    Translation:Humans
    52. Ellis LM, Bernstein DS, Voest EE, Berlin JD, Sargent D, Cortazar P, Garrett-Mayer E, Herbst RS, Lilenbaum RC, Sima C, Venook AP, Gonen M, Schilsky RL, Meropol NJ, Schnipper LE. American Society of Clinical Oncology perspective: Raising the bar for clinical trials by defining clinically meaningful outcomes. J Clin Oncol. 2014 Apr 20; 32(12):1277-80. PMID: 24638016.
      Citations: 130     Fields:    Translation:Humans
    53. Igoudjil W, Corvaisier M, Stechly L, Skrypek N, Langlois C, Grard G, Millet G, Leteurtre E, Dumont P, Hebbar M, Fan F, Ellis LM, Formstecher P, Van Seuningen I, Gespach C, Polakowska R, Huet G, Touil Y, Dessein AF, Vandomme J, Mont? D, Truant S, Pruvot FR. Colon cancer cells escape 5FU chemotherapy-induced cell death by entering stemness and quiescence associated with the c-Yes/YAP axis. Clin Cancer Res. 2014 Feb 15; 20(4):837-46. PMID: 24323901; PMCID: PMC4387277.
      Citations: 123     Fields:    Translation:HumansCells
    54. Yi J, Xiong W, Gong X, Bellister S, Ellis LM, Liu Q. Analysis of LGR4 receptor distribution in human and mouse tissues. PLoS One. 2013; 8(10):e78144. PMID: 24205130; PMCID: PMC3804454.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    55. Zhou Y, Bollu LR, Tozzi F, Ye X, Bhattacharya R, Gao G, Dupre E, Xia L, Lu J, Fan F, Bellister S, Ellis LM, Weihua Z. ATP citrate lyase mediates resistance of colorectal cancer cells to SN38. Mol Cancer Ther. 2013 Dec; 12(12):2782-91. PMID: 24132143; PMCID: PMC4302275.
      Citations: 32     Fields:    Translation:HumansCells
    56. Lieu CH, Tran H, Jiang ZQ, Mao M, Overman MJ, Lin E, Eng C, Morris J, Ellis L, Heymach JV, Kopetz S. The association of alternate VEGF ligands with resistance to anti-VEGF therapy in metastatic colorectal cancer. PLoS One. 2013; 8(10):e77117. PMID: 24143206; PMCID: PMC3797099.
      Citations: 55     Fields:    Translation:HumansCTClinical Trials
    57. Li M, Gao J, Feng R, Wang Y, Chen X, Sun J, Zhang D, Zhu Z, Ellis LM, Lu M, Lee JE, Feng Z, Liu B. Generation of monoclonal antibody MS17-57 targeting secreted alkaline phosphatase ectopically expressed on the surface of gastrointestinal cancer cells. PLoS One. 2013; 8(10):e77398. PMID: 24143229; PMCID: PMC3797039.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    58. Ye X, Fan F, Xia L, Ellis LM, Zhou Y, Wan G, Spizzo R, Ivan C, Mathur R, Hu X, Lu J, Calin GA, Lu X. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol. 2014 Feb; 8(1):83-92. PMID: 24145123; PMCID: PMC4124530.
      Citations: 86     Fields:    Translation:HumansCells
    59. Agarwal A, Chang GJ, Hu CY, Taggart M, Rashid A, Park IJ, You YN, Das P, Krishnan S, Crane CH, Rodriguez-Bigas M, Skibber J, Ellis L, Eng C, Kopetz S, Maru DM. Quantified pathologic response assessed as residual tumor burden is a predictor of recurrence-free survival in patients with rectal cancer who undergo resection after neoadjuvant chemoradiotherapy. Cancer. 2013 Dec 15; 119(24):4231-41. PMID: 24089344; PMCID: PMC5897128.
      Citations: 21     Fields:    Translation:Humans
    60. Ellis LM. An audience with : Lee M. Ellis. Interviewd by Man Tsuey Tse. Nat Rev Drug Discov. 2013 Aug; 12(8):572-3. PMID: 23868111.
      Citations:    Fields:    Translation:Humans
    61. Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep. 2013 Jun 27; 3(6):2100-12. PMID: 23791529; PMCID: PMC3796289.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    62. Mobley A, Linder SK, Braeuer R, Ellis LM, Zwelling L. A survey on data reproducibility in cancer research provides insights into our limited ability to translate findings from the laboratory to the clinic. PLoS One. 2013; 8(5):e63221. PMID: 23691000; PMCID: PMC3655010.
      Citations: 50     Fields:    Translation:Humans
    63. Maru D, Venook AP, Ellis LM. Predictive biomarkers for bevacizumab: are we there yet? Clin Cancer Res. 2013 Jun 01; 19(11):2824-7. PMID: 23549876.
      Citations: 26     Fields:    Translation:Humans
    64. Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, Ellis LM. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013 Feb 11; 23(2):171-85. PMID: 23375636; PMCID: PMC3574187.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    65. Roth BJ, Krilov L, Adams S, Aghajanian CA, Bach P, Braiteh F, Brose MS, Ellis LM, Erba H, George DJ, Gilbert MR, Jacobson JO, Larsen EC, Lichtman SM, Partridge AH, Patel JD, Quinn DI, Robison LL, von Roenn JH, Samlowski W, Schwartz GK, Vogelzang NJ. Clinical cancer advances 2012: annual report on progress against cancer from the american society of clinical oncology. J Clin Oncol. 2013 Jan 01; 31(1):131-61. PMID: 23213095.
      Citations: 19     Fields:    Translation:Humans
    66. Cutrera J, Johnson B, Ellis L, Li S. Intraosseous inoculation of tumor cells into bone marrow promotes distant metastatic tumor development: A novel tool for mechanistic and therapeutic studies. Cancer Lett. 2013 Feb 01; 329(1):68-73. PMID: 23111105; PMCID: PMC3535523.
      Citations: 3     Fields:    Translation:AnimalsCells
    67. Bilen MA, Taggart MW, Fournier K, Ellis LM, Mansfield PF, Eng C, Royal RE, Overman MJ. Pathologic complete response in poorly differentiated adenocarcinomas of the appendix: a case series. Acta Oncol. 2013 Jun; 52(5):1044-6. PMID: 23020527.
      Citations: 1     Fields:    Translation:Humans
    68. Tzeng CW, Aloia TA, Vauthey JN, Chang GJ, Ellis LM, Feig BW, Curley SA, Skibber JM, Abdalla EK, You YN, Rodriguez-Bigas MA. Morbidity of staged proctectomy after hepatectomy for colorectal cancer: a matched case-control analysis. Ann Surg Oncol. 2013 Feb; 20(2):482-90. PMID: 22932858.
      Citations: 3     Fields:    Translation:Humans
    69. Ellis L, Widmayer A, Das S. Maternal smoking during pregnancy and self-reported delinquency by offspring. Crim Behav Ment Health. 2012 Dec; 22(5):325-35. PMID: 22696101.
      Citations: 1     Fields:    Translation:Humans
    70. Fan F, Samuel S, Evans KW, Lu J, Xia L, Zhou Y, Sceusi E, Tozzi F, Ye XC, Mani SA, Ellis LM. Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells. Cancer Med. 2012 Aug; 1(1):5-16. PMID: 23342249; PMCID: PMC3544430.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    71. Lin M, Eng C, Hawk ET, Huang M, Lin J, Gu J, Ellis LM, Wu X. Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma. Cancer. 2012 Dec 15; 118(24):6188-98. PMID: 22673945; PMCID: PMC3465518.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    72. Lin M, Gu J, Eng C, Ellis LM, Hildebrandt MA, Lin J, Huang M, Calin GA, Wang D, Dubois RN, Hawk ET, Wu X. Genetic polymorphisms in MicroRNA-related genes as predictors of clinical outcomes in colorectal adenocarcinoma patients. Clin Cancer Res. 2012 Jul 15; 18(14):3982-91. PMID: 22661538; PMCID: PMC4141857.
      Citations: 35     Fields:    Translation:Humans
    73. Dai J, Gu J, Huang M, Eng C, Kopetz ES, Ellis LM, Hawk E, Wu X. GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes. Carcinogenesis. 2012 Jul; 33(7):1327-31. PMID: 22505654; PMCID: PMC4072910.
      Citations: 30     Fields:    Translation:Humans
    74. Begley CG, Ellis LM. Drug development: Raise standards for preclinical cancer research. Nature. 2012 Mar 28; 483(7391):531-3. PMID: 22460880.
      Citations: 854     Fields:    Translation:HumansAnimalsCells
    75. Jayson GC, Hicklin DJ, Ellis LM. Antiangiogenic therapy--evolving view based on clinical trial results. Nat Rev Clin Oncol. 2012 02 14; 9(5):297-303. PMID: 22330688.
      Citations: 71     Fields:    Translation:Humans
    76. Lin M, Eng C, Hawk ET, Huang M, Greisinger AJ, Gu J, Ellis LM, Wu X, Lin J. Genetic variants within ultraconserved elements and susceptibility to right- and left-sided colorectal adenocarcinoma. Carcinogenesis. 2012 Apr; 33(4):841-7. PMID: 22318908; PMCID: PMC3324446.
      Citations: 3     Fields:    Translation:HumansCells
    77. Sood AK, Coleman RL, Ellis LM. Moving beyond anti-vascular endothelial growth factor therapy in ovarian cancer. J Clin Oncol. 2012 Feb 01; 30(4):345-7. PMID: 22184398.
      Citations: 7     Fields:    Translation:HumansAnimals
    78. Marsland T, Arena F, Yeilding A, Ellis L, Yu J, Henderson C, Wagman L, Piver S, Minsky B, Rosen S, Poplack D, Potters L, Crawford D, Hoskins W, Glod? M. Perspective on...the new PSA screening recommendations. Oncology (Williston Park). 2011 Nov 15; 25(12):1183, 1187-8, 1190. PMID: 22229211.
      Citations:    Fields:    Translation:Humans
    79. Zhou Y, Tozzi F, Chen J, Fan F, Xia L, Wang J, Gao G, Zhang A, Xia X, Brasher H, Widger W, Ellis LM, Weihua Z. Intracellular ATP levels are a pivotal determinant of chemoresistance in colon cancer cells. Cancer Res. 2012 Jan 01; 72(1):304-14. PMID: 22084398; PMCID: PMC3601736.
      Citations: 133     Fields:    Translation:HumansCells
    80. Pecot CV, Bischoff FZ, Mayer JA, Wong KL, Pham T, Bottsford-Miller J, Stone RL, Lin YG, Jaladurgam P, Roh JW, Goodman BW, Merritt WM, Pircher TJ, Mikolajczyk SD, Nick AM, Celestino J, Eng C, Ellis LM, Deavers MT, Sood AK. A novel platform for detection of CK+ and CK- CTCs. Cancer Discov. 2011 Dec; 1(7):580-6. PMID: 22180853; PMCID: PMC3237635.
      Citations: 86     Fields:    Translation:HumansCells
    81. Samuel S, Gaur P, Fan F, Xia L, Gray MJ, Dallas NA, Bose D, Rodriguez-Aguayo C, Lopez-Berestein G, Plowman G, Bagri A, Sood AK, Ellis LM. Neuropilin-2 mediated ?-catenin signaling and survival in human gastro-intestinal cancer cell lines. PLoS One. 2011; 6(10):e23208. PMID: 22028766; PMCID: PMC3197582.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    82. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011 Nov; 121(11):4526-36. PMID: 21985787; PMCID: PMC3204827.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    83. Parikh AA, Ellis LM. Circulating angiogenic factors, tumor cells, and outcome after resection of metastatic colorectal cancer--what does it mean? Ann Surg Oncol. 2011 Aug; 18(8):2111-3. PMID: 21626082.
      Citations: 1     Fields:    Translation:HumansCells
    84. Gaur P, Sceusi EL, Samuel S, Xia L, Fan F, Zhou Y, Lu J, Tozzi F, Lopez-Berestein G, Vivas-Mejia P, Rashid A, Fleming JB, Abdalla EK, Curley SA, Vauthey JN, Sood AK, Yao JC, Ellis LM. Identification of cancer stem cells in human gastrointestinal carcinoid and neuroendocrine tumors. Gastroenterology. 2011 Nov; 141(5):1728-37. PMID: 21806944; PMCID: PMC3202668.
      Citations: 31     Fields:    Translation:HumansCells
    85. Gonzalez-Angulo AM, Hortobagyi GN, Ellis LM. Targeted therapies: peaking beneath the surface of recent bevacizumab trials. Nat Rev Clin Oncol. 2011 Jun; 8(6):319-20. PMID: 21556024.
      Citations: 9     Fields:    Translation:Humans
    86. Shahzad MM, Mangala LS, Han HD, Lu C, Bottsford-Miller J, Nishimura M, Mora EM, Lee JW, Stone RL, Pecot CV, Thanapprapasr D, Roh JW, Gaur P, Nair MP, Park YY, Sabnis N, Deavers MT, Lee JS, Ellis LM, Lopez-Berestein G, McConathy WJ, Prokai L, Lacko AG, Sood AK. Targeted delivery of small interfering RNA using reconstituted high-density lipoprotein nanoparticles. Neoplasia. 2011 Apr; 13(4):309-19. PMID: 21472135; PMCID: PMC3071079.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    87. Kulke MH, Siu LL, Tepper JE, Fisher G, Jaffe D, Haller DG, Ellis LM, Benedetti JK, Bergsland EK, Hobday TJ, Van Cutsem E, Pingpank J, Oberg K, Cohen SJ, Posner MC, Yao JC. Future directions in the treatment of neuroendocrine tumors: consensus report of the National Cancer Institute Neuroendocrine Tumor clinical trials planning meeting. J Clin Oncol. 2011 Mar 01; 29(7):934-43. PMID: 21263089; PMCID: PMC3068065.
      Citations: 112     Fields:    Translation:Humans
    88. Ellis LM, Samuel S, Sceusi E. Varying opinions on the authenticity of a human midgut carcinoid cell line--letter. Clin Cancer Res. 2010 Nov 01; 16(21):5365-6. PMID: 20959409.
      Citations: 15     Fields:    Translation:HumansCells
    89. Ellis LM, Fidler IJ. Finding the tumor copycat. Therapy fails, patients don't. Nat Med. 2010 Sep; 16(9):974-5. PMID: 20823880.
      Citations: 52     Fields:    Translation:HumansAnimals
    90. Ellis LM, Reardon DA. Is there really a yin and yang to VEGF-targeted therapies? Lancet Oncol. 2010 Sep; 11(9):809-11. PMID: 20634133.
      Citations: 6     Fields:    Translation:HumansAnimals
    91. Bose D, Meric-Bernstam F, Hofstetter W, Reardon DA, Flaherty KT, Ellis LM. Vascular endothelial growth factor targeted therapy in the perioperative setting: implications for patient care. Lancet Oncol. 2010 Apr; 11(4):373-82. PMID: 20171141.
      Citations: 42     Fields:    Translation:Humans
    92. Zeitlin BD, Ellis LM, N?r JE. Inhibition of Vascular Endothelial Growth Factor Receptor-1/Wnt/{beta}-catenin Crosstalk Leads to Tumor Cell Death. Clin Cancer Res. 2009 Dec 15; 15(24):7453-7455. PMID: 20008844; PMCID: PMC2796551.
      Citations: 9     Fields:    
    93. Ellis LM, Hicklin DJ. Resistance to Targeted Therapies: Refining Anticancer Therapy in the Era of Molecular Oncology. Clin Cancer Res. 2009 Dec 15; 15(24):7471-7478. PMID: 20008847.
      Citations: 104     Fields:    
    94. Kopetz S, Hoff PM, Morris JS, Wolff RA, Eng C, Glover KY, Adinin R, Overman MJ, Valero V, Wen S, Lieu C, Yan S, Tran HT, Ellis LM, Abbruzzese JL, Heymach JV. Phase II trial of infusional fluorouracil, irinotecan, and bevacizumab for metastatic colorectal cancer: efficacy and circulating angiogenic biomarkers associated with therapeutic resistance. J Clin Oncol. 2010 Jan 20; 28(3):453-9. PMID: 20008624; PMCID: PMC2815707.
      Citations: 186     Fields:    Translation:HumansCTClinical Trials
    95. Gaur P, Bielenberg DR, Samuel S, Bose D, Zhou Y, Gray MJ, Dallas NA, Fan F, Xia L, Lu J, Ellis LM. Role of class 3 semaphorins and their receptors in tumor growth and angiogenesis. Clin Cancer Res. 2009 Nov 15; 15(22):6763-70. PMID: 19887479.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    96. Philip PA, Mooney M, Jaffe D, Eckhardt G, Moore M, Meropol N, Emens L, O'Reilly E, Korc M, Ellis L, Benedetti J, Rothenberg M, Willett C, Tempero M, Lowy A, Abbruzzese J, Simeone D, Hingorani S, Berlin J, Tepper J. Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. J Clin Oncol. 2009 Nov 20; 27(33):5660-9. PMID: 19858397; PMCID: PMC7587401.
      Citations: 100     Fields:    Translation:HumansAnimals
    97. Van Buren G, Gray MJ, Dallas NA, Xia L, Lim SJ, Fan F, Mazar AP, Ellis LM. Targeting the urokinase plasminogen activator receptor with a monoclonal antibody impairs the growth of human colorectal cancer in the liver. Cancer. 2009 Jul 15; 115(14):3360-8. PMID: 19484792; PMCID: PMC4608018.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    98. Crane CH, Eng C, Feig BW, Das P, Skibber JM, Chang GJ, Wolff RA, Krishnan S, Hamilton S, Janjan NA, Maru DM, Ellis LM, Rodriguez-Bigas MA. Phase II trial of neoadjuvant bevacizumab, capecitabine, and radiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):824-30. PMID: 19464823.
      Citations: 71     Fields:    Translation:HumansCTClinical Trials
    99. Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. Cancer Res. 2009 May 01; 69(9):3842-9. PMID: 19383922; PMCID: PMC2709758.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    100. Gaur P, Bose D, Samuel S, Ellis LM. Targeting tumor angiogenesis. Semin Oncol. 2009 Apr; 36(2 Suppl 1):S12-9. PMID: 19393831.
      Citations: 15     Fields:    Translation:HumansCells
    101. Ellis LM, Reardon DA. Cancer: The nuances of therapy. Nature. 2009 Mar 19; 458(7236):290-2. PMID: 19295595.
      Citations: 30     Fields:    Translation:HumansAnimals
    102. Spannuth WA, Nick AM, Jennings NB, Armaiz-Pena GN, Mangala LS, Danes CG, Lin YG, Merritt WM, Thaker PH, Kamat AA, Han LY, Tonra JR, Coleman RL, Ellis LM, Sood AK. Functional significance of VEGFR-2 on ovarian cancer cells. Int J Cancer. 2009 Mar 01; 124(5):1045-53. PMID: 19058181; PMCID: PMC2668132.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    103. Dallas NA, Xia L, Fan F, Gray MJ, Gaur P, van Buren G, Samuel S, Kim MP, Lim SJ, Ellis LM. Chemoresistant colorectal cancer cells, the cancer stem cell phenotype, and increased sensitivity to insulin-like growth factor-I receptor inhibition. Cancer Res. 2009 Mar 01; 69(5):1951-7. PMID: 19244128; PMCID: PMC3198868.
      Citations: 252     Fields:    Translation:HumansAnimalsCells
    104. Dallas NA, Gray MJ, Xia L, Fan F, van Buren G, Gaur P, Samuel S, Lim SJ, Arumugam T, Ramachandran V, Wang H, Ellis LM. Neuropilin-2-mediated tumor growth and angiogenesis in pancreatic adenocarcinoma. Clin Cancer Res. 2008 Dec 15; 14(24):8052-60. PMID: 19088020.
      Citations: 40     Fields:    Translation:HumansCells
    105. Blazer DG, Kishi Y, Maru DM, Kopetz S, Chun YS, Overman MJ, Fogelman D, Eng C, Chang DZ, Wang H, Zorzi D, Ribero D, Ellis LM, Glover KY, Wolff RA, Curley SA, Abdalla EK, Vauthey JN. Pathologic response to preoperative chemotherapy: a new outcome end point after resection of hepatic colorectal metastases. J Clin Oncol. 2008 Nov 20; 26(33):5344-51. PMID: 18936472.
      Citations: 175     Fields:    Translation:Humans
    106. Hassan MM, Spitz MR, Thomas MB, El-Deeb AS, Glover KY, Nguyen NT, Chan W, Kaseb A, Curley SA, Vauthey JN, Ellis LM, Abdalla E, Lozano RD, Patt YZ, Brown TD, Abbruzzese JL, Li D. Effect of different types of smoking and synergism with hepatitis C virus on risk of hepatocellular carcinoma in American men and women: case-control study. Int J Cancer. 2008 Oct 15; 123(8):1883-91. PMID: 18688864; PMCID: PMC2673571.
      Citations: 29     Fields:    Translation:HumansPHPublic Health
    107. Ellis LM, Hicklin DJ. Pathways mediating resistance to vascular endothelial growth factor-targeted therapy. Clin Cancer Res. 2008 Oct 15; 14(20):6371-5. PMID: 18927275.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    108. Kesmodel SB, Ellis LM, Lin E, Chang GJ, Abdalla EK, Kopetz S, Vauthey JN, Rodriguez-Bigas MA, Curley SA, Feig BW. Preoperative bevacizumab does not significantly increase postoperative complication rates in patients undergoing hepatic surgery for colorectal cancer liver metastases. J Clin Oncol. 2008 Nov 10; 26(32):5254-60. PMID: 18854565.
      Citations: 44     Fields:    Translation:Humans
    109. Ellis LM, Haller DG. Bevacizumab beyond progression: does this make sense? J Clin Oncol. 2008 Nov 20; 26(33):5313-5. PMID: 18854567.
      Citations: 8     Fields:    Translation:Humans
    110. Fan F, Gray MJ, Dallas NA, Yang AD, Van Buren G, Camp ER, Ellis LM. Effect of chemotherapeutic stress on induction of vascular endothelial growth factor family members and receptors in human colorectal cancer cells. Mol Cancer Ther. 2008 Sep; 7(9):3064-70. PMID: 18790786; PMCID: PMC2581833.
      Citations: 11     Fields:    Translation:HumansCells
    111. Ellis LM, Hicklin DJ. VEGF-targeted therapy: mechanisms of anti-tumour activity. Nat Rev Cancer. 2008 Aug; 8(8):579-91. PMID: 18596824.
      Citations: 614     Fields:    Translation:Humans
    112. Yang L, Hamilton SR, Sood A, Kuwai T, Ellis L, Sanguino A, Lopez-Berestein G, Boyd DD. The previously undescribed ZKSCAN3 (ZNF306) is a novel "driver" of colorectal cancer progression. Cancer Res. 2008 Jun 01; 68(11):4321-30. PMID: 18519692.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    113. Grothey A, Ellis LM. Targeting angiogenesis driven by vascular endothelial growth factors using antibody-based therapies. Cancer J. 2008 May-Jun; 14(3):170-7. PMID: 18536556.
      Citations: 26     Fields:    Translation:HumansCells
    114. Van Buren G, Yang AD, Dallas NA, Gray MJ, Lim SJ, Xia L, Fan F, Somcio R, Wu Y, Hicklin DJ, Ellis LM. Effect of molecular therapeutics on liver regeneration in a murine model. J Clin Oncol. 2008 Apr 10; 26(11):1836-42. PMID: 18398149.
      Citations: 21     Fields:    Translation:Animals
    115. Dallas NA, Samuel S, Xia L, Fan F, Gray MJ, Lim SJ, Ellis LM. Endoglin (CD105): a marker of tumor vasculature and potential target for therapy. Clin Cancer Res. 2008 Apr 01; 14(7):1931-7. PMID: 18381930.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    116. Lu C, Thaker PH, Lin YG, Spannuth W, Landen CN, Merritt WM, Jennings NB, Langley RR, Gershenson DM, Yancopoulos GD, Ellis LM, Jaffe RB, Coleman RL, Sood AK. Impact of vessel maturation on antiangiogenic therapy in ovarian cancer. Am J Obstet Gynecol. 2008 Apr; 198(4):477.e1-9; discussion 477.e9-10. PMID: 18395047; PMCID: PMC2346589.
      Citations: 20     Fields:    Translation:AnimalsCells
    117. Gray MJ, Van Buren G, Dallas NA, Xia L, Wang X, Yang AD, Somcio RJ, Lin YG, Lim S, Fan F, Mangala LS, Arumugam T, Logsdon CD, Lopez-Berestein G, Sood AK, Ellis LM. Therapeutic targeting of neuropilin-2 on colorectal carcinoma cells implanted in the murine liver. J Natl Cancer Inst. 2008 Jan 16; 100(2):109-20. PMID: 18182619.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    118. Ribero D, Wang H, Donadon M, Zorzi D, Thomas MB, Eng C, Chang DZ, Curley SA, Abdalla EK, Ellis LM, Vauthey JN. Bevacizumab improves pathologic response and protects against hepatic injury in patients treated with oxaliplatin-based chemotherapy for colorectal liver metastases. Cancer. 2007 Dec 15; 110(12):2761-7. PMID: 17960603.
      Citations: 118     Fields:    Translation:Humans
    119. Prewett M, Deevi DS, Bassi R, Fan F, Ellis LM, Hicklin DJ, Tonra JR. Tumors established with cell lines selected for oxaliplatin resistance respond to oxaliplatin if combined with cetuximab. Clin Cancer Res. 2007 Dec 15; 13(24):7432-40. PMID: 18094427.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    120. Dallas NA, Fan F, Gray MJ, Van Buren G, Lim SJ, Xia L, Ellis LM. Functional significance of vascular endothelial growth factor receptors on gastrointestinal cancer cells. Cancer Metastasis Rev. 2007 Dec; 26(3-4):433-41. PMID: 17786539.
      Citations: 24     Fields:    Translation:HumansAnimals
    121. Stoeltzing O, Liu W, Fan F, Wagner C, Stengel K, Somcio RJ, Reinmuth N, Parikh AA, Hicklin DJ, Ellis LM. Regulation of cyclooxygenase-2 (COX-2) expression in human pancreatic carcinoma cells by the insulin-like growth factor-I receptor (IGF-IR) system. Cancer Lett. 2007 Dec 18; 258(2):291-300. PMID: 17950526; PMCID: PMC2147684.
      Citations: 8     Fields:    Translation:HumansCells
    122. Van Buren G, Rashid A, Yang AD, Abdalla EK, Gray MJ, Liu W, Somcio R, Fan F, Camp ER, Yao JC, Ellis LM. The development and characterization of a human midgut carcinoid cell line. Clin Cancer Res. 2007 Aug 15; 13(16):4704-12. PMID: 17699847.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    123. McCarty MF, Somcio RJ, Stoeltzing O, Wey J, Fan F, Liu W, Bucana C, Ellis LM. Overexpression of PDGF-BB decreases colorectal and pancreatic cancer growth by increasing tumor pericyte content. J Clin Invest. 2007 Aug; 117(8):2114-22. PMID: 17641778; PMCID: PMC1913488.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    124. Bauer TW, Fan F, Liu W, Camp ER, Yang A, Somcio RJ, Bucana CD, Singh R, Ellis LM. Targeting of insulin-like growth factor-I receptor with a monoclonal antibody inhibits growth of hepatic metastases from human colon carcinoma in mice. Ann Surg Oncol. 2007 Oct; 14(10):2838-46. PMID: 17653802.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    125. Hoff PM, Ellis LM. Targeted therapy trials: approval strategies, target validation, or helping patients? J Clin Oncol. 2007 May 01; 25(13):1639-41. PMID: 17470854.
      Citations: 5     Fields:    Translation:Humans
    126. Lang SA, Gaumann A, Koehl GE, Seidel U, Bataille F, Klein D, Ellis LM, Bolder U, Hofstaedter F, Geissler EK, Stoeltzing O, Schlitt HJ. Mammalian target of rapamycin is activated in human gastric cancer and serves as a target for therapy in an experimental model. Int J Cancer. 2007 Apr 15; 120(8):1803-10. PMID: 17230506.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    127. Camp ER, Yang A, Gray MJ, Fan F, Hamilton SR, Evans DB, Hooper AT, Pereira DS, Hicklin DJ, Ellis LM. Tyrosine kinase receptor RON in human pancreatic cancer: expression, function, and validation as a target. Cancer. 2007 Mar 15; 109(6):1030-9. PMID: 17311308.
      Citations: 45     Fields:    Translation:HumansCells
    128. Yao JC, Zhang JX, Rashid A, Yeung SC, Szklaruk J, Hess K, Xie K, Ellis L, Abbruzzese JL, Ajani JA. Clinical and in vitro studies of imatinib in advanced carcinoid tumors. Clin Cancer Res. 2007 Jan 01; 13(1):234-40. PMID: 17200360.
      Citations: 26     Fields:    Translation:HumansCellsCTClinical Trials
    129. Minard ME, Ellis LM, Gallick GE. Tiam1 regulates cell adhesion, migration and apoptosis in colon tumor cells. Clin Exp Metastasis. 2006; 23(5-6):301-13. PMID: 17086355.
      Citations: 49     Fields:    Translation:HumansCells
    130. Ellis LM. Mechanisms of action of bevacizumab as a component of therapy for metastatic colorectal cancer. Semin Oncol. 2006 Oct; 33(5 Suppl 10):S1-7. PMID: 17145519.
      Citations: 44     Fields:    Translation:Humans
    131. Van Buren G, Camp ER, Yang AD, Gray MJ, Fan F, Somcio R, Ellis LM. The role of nitric oxide in mediating tumour blood flow. Expert Opin Ther Targets. 2006 Oct; 10(5):689-701. PMID: 16981826.
      Citations: 5     Fields:    Translation:HumansAnimals
    132. Lee TH, Bolontrade MF, Worth LL, Guan H, Ellis LM, Kleinerman ES. Production of VEGF165 by Ewing's sarcoma cells induces vasculogenesis and the incorporation of CD34+ stem cells into the expanding tumor vasculature. Int J Cancer. 2006 Aug 15; 119(4):839-46. PMID: 16557578.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    133. Stoeltzing O, Meric-Bernstam F, Ellis LM. Intracellular signaling in tumor and endothelial cells: The expected and, yet again, the unexpected. Cancer Cell. 2006 Aug; 10(2):89-91. PMID: 16904605.
      Citations: 19     Fields:    Translation:HumansCells
    134. Yang AD, Fan F, Camp ER, van Buren G, Liu W, Somcio R, Gray MJ, Cheng H, Hoff PM, Ellis LM. Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell lines. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 1):4147-53. PMID: 16857785.
      Citations: 233     Fields:    Translation:HumansCells
    135. Bauer TW, Somcio RJ, Fan F, Liu W, Johnson M, Lesslie DP, Evans DB, Gallick GE, Ellis LM. Regulatory role of c-Met in insulin-like growth factor-I receptor-mediated migration and invasion of human pancreatic carcinoma cells. Mol Cancer Ther. 2006 Jul; 5(7):1676-82. PMID: 16891453.
      Citations: 47     Fields:    Translation:HumansCells
    136. Pawlik TM, Vauthey JN, Abdalla EK, Pollock RE, Ellis LM, Curley SA. Results of a single-center experience with resection and ablation for sarcoma metastatic to the liver. Arch Surg. 2006 Jun; 141(6):537-43; discussion 543-4. PMID: 16785353.
      Citations: 45     Fields:    Translation:Humans
    137. Das P, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Janjan NA, Delclos ME, Krishnan S, Levy LB, Ellis LM, Crane CH. Clinical and pathologic predictors of locoregional recurrence, distant metastasis, and overall survival in patients treated with chemoradiation and mesorectal excision for rectal cancer. Am J Clin Oncol. 2006 Jun; 29(3):219-24. PMID: 16755173.
      Citations: 56     Fields:    Translation:Humans
    138. Ellis LM. The role of neuropilins in cancer. Mol Cancer Ther. 2006 May; 5(5):1099-107. PMID: 16731741.
      Citations: 101     Fields:    Translation:HumansAnimalsCells
    139. Camp ER, Yang A, Liu W, Fan F, Somcio R, Hicklin DJ, Ellis LM. Roles of nitric oxide synthase inhibition and vascular endothelial growth factor receptor-2 inhibition on vascular morphology and function in an in vivo model of pancreatic cancer. Clin Cancer Res. 2006 Apr 15; 12(8):2628-33. PMID: 16638876.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    140. Crane CH, Ellis LM, Abbruzzese JL, Amos C, Xiong HQ, Ho L, Evans DB, Tamm EP, Ng C, Pisters PW, Charnsangavej C, Delclos ME, O'Reilly M, Lee JE, Wolff RA. Phase I trial evaluating the safety of bevacizumab with concurrent radiotherapy and capecitabine in locally advanced pancreatic cancer. J Clin Oncol. 2006 Mar 01; 24(7):1145-51. PMID: 16505434.
      Citations: 57     Fields:    Translation:HumansCTClinical Trials
    141. Scaife CL, Ng CS, Ellis LM, Vauthey JN, Charnsangavej C, Curley SA. Accuracy of preoperative imaging of hepatic tumors with helical computed tomography. Ann Surg Oncol. 2006 Apr; 13(4):542-6. PMID: 16474907.
      Citations: 7     Fields:    Translation:Humans
    142. Bedrosian I, Giacco G, Pederson L, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane CH, Janjan N, Skibber JM. Outcome after curative resection for locally recurrent rectal cancer. Dis Colon Rectum. 2006 Feb; 49(2):175-82. PMID: 16392024.
      Citations: 15     Fields:    Translation:Humans
    143. Pawlik TM, Abdalla EK, Ellis LM, Vauthey JN, Curley SA. Debunking dogma: surgery for four or more colorectal liver metastases is justified. J Gastrointest Surg. 2006 Feb; 10(2):240-8. PMID: 16455457.
      Citations: 28     Fields:    Translation:Humans
    144. Yang AD, Camp ER, Fan F, Shen L, Gray MJ, Liu W, Somcio R, Bauer TW, Wu Y, Hicklin DJ, Ellis LM. Vascular endothelial growth factor receptor-1 activation mediates epithelial to mesenchymal transition in human pancreatic carcinoma cells. Cancer Res. 2006 Jan 01; 66(1):46-51. PMID: 16397214.
      Citations: 101     Fields:    Translation:HumansCells
    145. Ellis LM, Rosen L, Gordon MS. Overview of anti-VEGF therapy and angiogenesis. Part 1: Angiogenesis inhibition in solid tumor malignancies. Clin Adv Hematol Oncol. 2006 Jan; 4(1):suppl 1-10; quz 11-2. PMID: 16562372.
      Citations: 16     Fields:    Translation:Humans
    146. Liu W, Parikh AA, Stoeltzing O, Fan F, McCarty MF, Wey J, Hicklin DJ, Ellis LM. Upregulation of neuropilin-1 by basic fibroblast growth factor enhances vascular smooth muscle cell migration in response to VEGF. Cytokine. 2005 Dec 07; 32(5):206-12. PMID: 16289960.
      Citations: 20     Fields:    Translation:HumansCells
    147. Kan Z, Phongkitkarun S, Kobayashi S, Tang Y, Ellis LM, Lee TY, Charnsangavej C. Functional CT for quantifying tumor perfusion in antiangiogenic therapy in a rat model. Radiology. 2005 Oct; 237(1):151-8. PMID: 16183931.
      Citations: 46     Fields:    Translation:Animals
    148. Bauer TW, Liu W, Fan F, Camp ER, Yang A, Somcio RJ, Bucana CD, Callahan J, Parry GC, Evans DB, Boyd DD, Mazar AP, Ellis LM. Targeting of urokinase plasminogen activator receptor in human pancreatic carcinoma cells inhibits c-Met- and insulin-like growth factor-I receptor-mediated migration and invasion and orthotopic tumor growth in mice. Cancer Res. 2005 Sep 01; 65(17):7775-81. PMID: 16140945.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    149. Ellis LM, Curley SA, Grothey A. Surgical resection after downsizing of colorectal liver metastasis in the era of bevacizumab. J Clin Oncol. 2005 Aug 01; 23(22):4853-5. PMID: 16051943.
      Citations: 35     Fields:    Translation:Humans
    150. Wey JS, Fan F, Gray MJ, Bauer TW, McCarty MF, Somcio R, Liu W, Evans DB, Wu Y, Hicklin DJ, Ellis LM. Vascular endothelial growth factor receptor-1 promotes migration and invasion in pancreatic carcinoma cell lines. Cancer. 2005 Jul 15; 104(2):427-38. PMID: 15952180.
      Citations: 65     Fields:    Translation:HumansCells
    151. Raut CP, Izzo F, Marra P, Ellis LM, Vauthey JN, Cremona F, Vallone P, Mastro A, Fornage BD, Curley SA. Significant long-term survival after radiofrequency ablation of unresectable hepatocellular carcinoma in patients with cirrhosis. Ann Surg Oncol. 2005 Aug; 12(8):616-28. PMID: 15965731.
      Citations: 37     Fields:    Translation:Humans
    152. Bauer TW, Fan F, Liu W, Johnson M, Parikh NU, Parry GC, Callahan J, Mazar AP, Gallick GE, Ellis LM. Insulinlike growth factor-I-mediated migration and invasion of human colon carcinoma cells requires activation of c-Met and urokinase plasminogen activator receptor. Ann Surg. 2005 May; 241(5):748-56; discussion 756-8. PMID: 15849510; PMCID: PMC1357129.
      Citations: 23     Fields:    Translation:HumansCells
    153. Gray MJ, Wey JS, Belcheva A, McCarty MF, Trevino JG, Evans DB, Ellis LM, Gallick GE. Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res. 2005 May 01; 65(9):3664-70. PMID: 15867361.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    154. Ellis LM. Bevacizumab. Nat Rev Drug Discov. 2005 May; Suppl:S8-9. PMID: 15962523.
      Citations: 26     Fields:    Translation:Humans
    155. Gray MJ, Zhang J, Ellis LM, Semenza GL, Evans DB, Watowich SS, Gallick GE. HIF-1alpha, STAT3, CBP/p300 and Ref-1/APE are components of a transcriptional complex that regulates Src-dependent hypoxia-induced expression of VEGF in pancreatic and prostate carcinomas. Oncogene. 2005 Apr 28; 24(19):3110-20. PMID: 15735682.
      Citations: 153     Fields:    Translation:HumansCells
    156. Yang AD, Bauer TW, Camp ER, Somcio R, Liu W, Fan F, Ellis LM. Improving delivery of antineoplastic agents with anti-vascular endothelial growth factor therapy. Cancer. 2005 Apr 15; 103(8):1561-70. PMID: 15754332.
      Citations: 11     Fields:    Translation:HumansAnimals
    157. Fan F, Wey JS, McCarty MF, Belcheva A, Liu W, Bauer TW, Somcio RJ, Wu Y, Hooper A, Hicklin DJ, Ellis LM. Expression and function of vascular endothelial growth factor receptor-1 on human colorectal cancer cells. Oncogene. 2005 Apr 14; 24(16):2647-53. PMID: 15735759.
      Citations: 110     Fields:    Translation:HumansCells
    158. Camp ER, Liu W, Fan F, Yang A, Somcio R, Ellis LM. RON, a tyrosine kinase receptor involved in tumor progression and metastasis. Ann Surg Oncol. 2005 Apr; 12(4):273-81. PMID: 15827676.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    159. Camp ER, Summy J, Bauer TW, Liu W, Gallick GE, Ellis LM. Molecular mechanisms of resistance to therapies targeting the epidermal growth factor receptor. Clin Cancer Res. 2005 Jan 01; 11(1):397-405. PMID: 15671571.
      Citations: 72     Fields:    Translation:HumansCells
    160. Raut CP, Nawrocki S, Lashinger LM, Davis DW, Khanbolooki S, Xiong H, Ellis LM, McConkey DJ. Celecoxib inhibits angiogenesis by inducing endothelial cell apoptosis in human pancreatic tumor xenografts. Cancer Biol Ther. 2004 Dec; 3(12):1217-24. PMID: 15477758.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    161. Hicklin DJ, Ellis LM. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol. 2005 Feb 10; 23(5):1011-27. PMID: 15585754.
      Citations: 914     Fields:    Translation:HumansAnimalsCells
    162. Ellis LM. Angiogenesis and its role in colorectal tumor and metastasis formation. Semin Oncol. 2004 Dec; 31(6 Suppl 17):3-9. PMID: 15696024.
      Citations: 14     Fields:    Translation:HumansAnimals
    163. Vidal CI, Mintz PJ, Lu K, Ellis LM, Manenti L, Giavazzi R, Gershenson DM, Broaddus R, Liu J, Arap W, Pasqualini R. An HSP90-mimic peptide revealed by fingerprinting the pool of antibodies from ovarian cancer patients. Oncogene. 2004 Nov 25; 23(55):8859-67. PMID: 15480432.
      Citations: 25     Fields:    Translation:HumansCells
    164. Kabbinavar FF, Ellis LM. Can inhibition of angiogenic pathways increase the efficacy of intravenous 5-fluorouracil-based regimens? Clin Colorectal Cancer. 2004 Oct; 4 Suppl 2:S69-73. PMID: 15479482.
      Citations: 3     Fields:    Translation:HumansCTClinical Trials
    165. Parikh AA, Ellis LM. The vascular endothelial growth factor family and its receptors. Hematol Oncol Clin North Am. 2004 Oct; 18(5):951-71, vii. PMID: 15474329.
      Citations: 19     Fields:    Translation:HumansAnimals
    166. Ellis LM. Preclinical data targeting vascular endothelial growth factor in colorectal cancer. Clin Colorectal Cancer. 2004 Oct; 4 Suppl 2:S55-61. PMID: 15479480.
      Citations: 5     Fields:    Translation:Animals
    167. McCarty MF, Wey J, Stoeltzing O, Liu W, Fan F, Bucana C, Mansfield PF, Ryan AJ, Ellis LM. ZD6474, a vascular endothelial growth factor receptor tyrosine kinase inhibitor with additional activity against epidermal growth factor receptor tyrosine kinase, inhibits orthotopic growth and angiogenesis of gastric cancer. Mol Cancer Ther. 2004 Sep; 3(9):1041-8. PMID: 15367698.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    168. Ellis L, Haman D. Population increases in obesity appear to be partly due to genetics. J Biosoc Sci. 2004 Sep; 36(5):547-59. PMID: 15446351.
      Citations: 3     Fields:    Translation:Humans
    169. Kawaguchi M, Akagi M, Gray MJ, Liu W, Fan F, Ellis LM. Regulation of vascular endothelial growth factor expression in human gastric cancer cells by interleukin-1beta. Surgery. 2004 Sep; 136(3):686-92. PMID: 15349119.
      Citations: 4     Fields:    Translation:HumansCells
    170. Vlastos G, Smith DL, Singletary SE, Mirza NQ, Tuttle TM, Popat RJ, Curley SA, Ellis LM, Roh MS, Vauthey JN. Long-term survival after an aggressive surgical approach in patients with breast cancer hepatic metastases. Ann Surg Oncol. 2004 Sep; 11(9):869-74. PMID: 15342348.
      Citations: 44     Fields:    Translation:Humans
    171. Hwang YS, Jeong M, Park JS, Kim MH, Lee DB, Shin BA, Mukaida N, Ellis LM, Kim HR, Ahn BW, Jung YD. Interleukin-1beta stimulates IL-8 expression through MAP kinase and ROS signaling in human gastric carcinoma cells. Oncogene. 2004 Aug 26; 23(39):6603-11. PMID: 15208668.
      Citations: 44     Fields:    Translation:HumansCells
    172. Mullen JT, Donahue JM, Chandrasekhar S, Yoon SS, Liu W, Ellis LM, Nakamura H, Kasuya H, Pawlik TM, Tanabe KK. Oncolysis by viral replication and inhibition of angiogenesis by a replication-conditional herpes simplex virus that expresses mouse endostatin. Cancer. 2004 Aug 15; 101(4):869-77. PMID: 15305421.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    173. Patt YZ, Hassan MM, Aguayo A, Nooka AK, Lozano RD, Curley SA, Vauthey JN, Ellis LM, Schnirer II, Wolff RA, Charnsangavej C, Brown TD. Oral capecitabine for the treatment of hepatocellular carcinoma, cholangiocarcinoma, and gallbladder carcinoma. Cancer. 2004 Aug 01; 101(3):578-86. PMID: 15274071.
      Citations: 63     Fields:    Translation:Humans
    174. Ellis LM. Current overview of angiogenesis inhibitors. Clin Adv Hematol Oncol. 2004 Aug; 2(8):494-6, 520. PMID: 16163228.
      Citations:    Fields:    Translation:Humans
    175. Fidler IJ, Ellis LM. Neoplastic angiogenesis--not all blood vessels are created equal. N Engl J Med. 2004 Jul 15; 351(3):215-6. PMID: 15254281.
      Citations: 14     Fields:    Translation:HumansCells
    176. Faria SC, Iyer RB, Rashid A, Ellis L, Whitman GJ. Desmoid tumor of the small bowel and the mesentery. AJR Am J Roentgenol. 2004 Jul; 183(1):118. PMID: 15208123.
      Citations: 25     Fields:    Translation:Humans
    177. Stoeltzing O, McCarty MF, Wey JS, Fan F, Liu W, Belcheva A, Bucana CD, Semenza GL, Ellis LM. Role of hypoxia-inducible factor 1alpha in gastric cancer cell growth, angiogenesis, and vessel maturation. J Natl Cancer Inst. 2004 Jun 16; 96(12):946-56. PMID: 15199114.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    178. Abdalla EK, Vauthey JN, Ellis LM, Ellis V, Pollock R, Broglio KR, Hess K, Curley SA. Recurrence and outcomes following hepatic resection, radiofrequency ablation, and combined resection/ablation for colorectal liver metastases. Ann Surg. 2004 Jun; 239(6):818-25; discussion 825-7. PMID: 15166961; PMCID: PMC1356290.
      Citations: 570     Fields:    Translation:Humans
    179. Parikh AA, Fan F, Liu WB, Ahmad SA, Stoeltzing O, Reinmuth N, Bielenberg D, Bucana CD, Klagsbrun M, Ellis LM. Neuropilin-1 in human colon cancer: expression, regulation, and role in induction of angiogenesis. Am J Pathol. 2004 Jun; 164(6):2139-51. PMID: 15161648; PMCID: PMC1615754.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    180. Vauthey JN, Pawlik TM, Abdalla EK, Arens JF, Nemr RA, Wei SH, Kennamer DL, Ellis LM, Curley SA. Is extended hepatectomy for hepatobiliary malignancy justified? Ann Surg. 2004 May; 239(5):722-30; discussion 730-2. PMID: 15082977; PMCID: PMC1356281.
      Citations: 101     Fields:    Translation:Humans
    181. Hoff PM, Ellis LM, Abbruzzese JL. Monoclonal antibodies: the foundation of therapy for colorectal cancer in the 21st century? Oncology (Williston Park). 2004 May; 18(6):736-41; discussion 742, 745-6. PMID: 15214593.
      Citations: 1     Fields:    Translation:Humans
    182. Fan F, Stoeltzing O, Liu W, McCarty MF, Jung YD, Reinmuth N, Ellis LM. Interleukin-1beta regulates angiopoietin-1 expression in human endothelial cells. Cancer Res. 2004 May 01; 64(9):3186-90. PMID: 15126358.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    183. Curley SA, Marra P, Beaty K, Ellis LM, Vauthey JN, Abdalla EK, Scaife C, Raut C, Wolff R, Choi H, Loyer E, Vallone P, Fiore F, Scordino F, De Rosa V, Orlando R, Pignata S, Daniele B, Izzo F. Early and late complications after radiofrequency ablation of malignant liver tumors in 608 patients. Ann Surg. 2004 Apr; 239(4):450-8. PMID: 15024305; PMCID: PMC1356249.
      Citations: 103     Fields:    Translation:Humans
    184. Ellis LM, Hoff PM. Targeting the epidermal growth factor receptor: an important incremental step in the battle against colorectal cancer. J Clin Oncol. 2004 Apr 01; 22(7):1177-9. PMID: 14993229.
      Citations: 8     Fields:    Translation:Humans
    185. Ruiz M, Pettaway C, Song R, Stoeltzing O, Ellis L, Bar-Eli M. Activator protein 2alpha inhibits tumorigenicity and represses vascular endothelial growth factor transcription in prostate cancer cells. Cancer Res. 2004 Jan 15; 64(2):631-8. PMID: 14744778.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    186. Bedrosian I, Rodriguez-Bigas MA, Feig B, Hunt KK, Ellis L, Curley SA, Vauthey JN, Delclos M, Crane C, Janjan N, Skibber JM. Predicting the node-negative mesorectum after preoperative chemoradiation for locally advanced rectal carcinoma. J Gastrointest Surg. 2004 Jan; 8(1):56-62; discussion 62-3. PMID: 14746836.
      Citations: 33     Fields:    Translation:Humans
    187. Stoeltzing O, Ellis LM. Regulators of vascular endothelial growth factor expression in cancer. Cancer Treat Res. 2004; 119:33-58. PMID: 15164872.
      Citations:    Fields:    Translation:HumansCells
    188. Wey JS, Stoeltzing O, Ellis LM. Vascular endothelial growth factor receptors: expression and function in solid tumors. Clin Adv Hematol Oncol. 2004 Jan; 2(1):37-45. PMID: 16163158.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    189. Parikh AA, Gentner B, Wu TT, Curley SA, Ellis LM, Vauthey JN. Perioperative complications in patients undergoing major liver resection with or without neoadjuvant chemotherapy. J Gastrointest Surg. 2003 Dec; 7(8):1082-8. PMID: 14675719.
      Citations: 57     Fields:    Translation:Humans
    190. Ellis LM. Antiangiogenic therapy at a crossroads: clinical trial results and future directions. J Clin Oncol. 2003 Dec 01; 21(23 Suppl):281s-283s. PMID: 14645411.
      Citations: 1     Fields:    Translation:HumansAnimals
    191. Esnaola NF, Mirza N, Lauwers GY, Ikai I, Regimbeau JM, Belghiti J, Yamaoka Y, Curley SA, Ellis LM, Nagorney DM, Vauthey JN. Comparison of clinicopathologic characteristics and outcomes after resection in patients with hepatocellular carcinoma treated in the United States, France, and Japan. Ann Surg. 2003 Nov; 238(5):711-9. PMID: 14578734; PMCID: PMC1356150.
      Citations: 20     Fields:    Translation:Humans
    192. Ellis LM. Antiangiogenic therapy: more promise and, yet again, more questions. J Clin Oncol. 2003 Nov 01; 21(21):3897-9. PMID: 14517185.
      Citations: 5     Fields:    Translation:Humans
    193. Stoeltzing O, Liu W, Reinmuth N, Fan F, Parikh AA, Bucana CD, Evans DB, Semenza GL, Ellis LM. Regulation of hypoxia-inducible factor-1alpha, vascular endothelial growth factor, and angiogenesis by an insulin-like growth factor-I receptor autocrine loop in human pancreatic cancer. Am J Pathol. 2003 Sep; 163(3):1001-11. PMID: 12937141; PMCID: PMC1868239.
      Citations: 66     Fields:    Translation:HumansCells
    194. Parikh AA, Liu WB, Fan F, Stoeltzing O, Reinmuth N, Bruns CJ, Bucana CD, Evans DB, Ellis LM. Expression and regulation of the novel vascular endothelial growth factor receptor neuropilin-1 by epidermal growth factor in human pancreatic carcinoma. Cancer. 2003 Aug 15; 98(4):720-9. PMID: 12910515.
      Citations: 33     Fields:    Translation:HumansCells
    195. Stoeltzing O, Liu W, Reinmuth N, Parikh A, Ahmad SA, Jung YD, Fan F, Ellis LM. Angiogenesis and antiangiogenic therapy of colon cancer liver metastasis. Ann Surg Oncol. 2003 Aug; 10(7):722-33. PMID: 12900362.
      Citations: 16     Fields:    Translation:HumansAnimals
    196. Adding a humanized antibody to vascular endothelial growth factor (Bevacizumab, Avastin) to chemotherapy improves survival in metastatic colorectal cancer. Clin Colorectal Cancer. 2003 Aug; 3(2):85-8. PMID: 12952562.
      Citations: 2     Fields:    Translation:Humans
    197. Liu W, Reinmuth N, Stoeltzing O, Parikh AA, Tellez C, Williams S, Jung YD, Fan F, Takeda A, Akagi M, Bar-Eli M, Gallick GE, Ellis LM. Cyclooxygenase-2 is up-regulated by interleukin-1 beta in human colorectal cancer cells via multiple signaling pathways. Cancer Res. 2003 Jul 01; 63(13):3632-6. PMID: 12839952.
      Citations: 43     Fields:    Translation:HumansCells
    198. Stoeltzing O, Ahmad SA, Liu W, McCarty MF, Wey JS, Parikh AA, Fan F, Reinmuth N, Kawaguchi M, Bucana CD, Ellis LM. Angiopoietin-1 inhibits vascular permeability, angiogenesis, and growth of hepatic colon cancer tumors. Cancer Res. 2003 Jun 15; 63(12):3370-7. PMID: 12810673.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    199. Herynk MH, Stoeltzing O, Reinmuth N, Parikh NU, Abounader R, Laterra J, Radinsky R, Ellis LM, Gallick GE. Down-regulation of c-Met inhibits growth in the liver of human colorectal carcinoma cells. Cancer Res. 2003 Jun 01; 63(11):2990-6. PMID: 12782608.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    200. Scaife CL, Curley SA, Izzo F, Marra P, Delrio P, Daniele B, Cremona F, Gershenwald JE, Chase JL, Lozano RD, Patt YZ, Fornage BD, Vauthey JN, Woodall ML, Gonzalez KB, Ellis LM. Feasibility of adjuvant hepatic arterial infusion of chemotherapy after radiofrequency ablation with or without resection in patients with hepatic metastases from colorectal cancer. Ann Surg Oncol. 2003 May; 10(4):348-54. PMID: 12734081.
      Citations: 7     Fields:    Translation:Humans
    201. Reinmuth N, Liu W, Ahmad SA, Fan F, Stoeltzing O, Parikh AA, Bucana CD, Gallick GE, Nickols MA, Westlin WF, Ellis LM. Alphavbeta3 integrin antagonist S247 decreases colon cancer metastasis and angiogenesis and improves survival in mice. Cancer Res. 2003 May 01; 63(9):2079-87. PMID: 12727823.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    202. Stoeltzing O, Liu W, Reinmuth N, Fan F, Parry GC, Parikh AA, McCarty MF, Bucana CD, Mazar AP, Ellis LM. Inhibition of integrin alpha5beta1 function with a small peptide (ATN-161) plus continuous 5-FU infusion reduces colorectal liver metastases and improves survival in mice. Int J Cancer. 2003 Apr 20; 104(4):496-503. PMID: 12584749.
      Citations: 85     Fields:    Translation:Animals
    203. McCarty MF, Liu W, Fan F, Parikh A, Reimuth N, Stoeltzing O, Ellis LM. Promises and pitfalls of anti-angiogenic therapy in clinical trials. Trends Mol Med. 2003 Feb; 9(2):53-8. PMID: 12615038.
      Citations: 10     Fields:    Translation:Humans
    204. Reinmuth N, Parikh AA, Ahmad SA, Liu W, Stoeltzing O, Fan F, Takeda A, Akagi M, Ellis LM. Biology of angiogenesis in tumors of the gastrointestinal tract. Microsc Res Tech. 2003 Feb 01; 60(2):199-207. PMID: 12539174.
      Citations: 29     Fields:    Translation:Humans
    205. Patt YZ, Hassan MM, Lozano RD, Brown TD, Vauthey JN, Curley SA, Ellis LM. Phase II trial of systemic continuous fluorouracil and subcutaneous recombinant interferon Alfa-2b for treatment of hepatocellular carcinoma. J Clin Oncol. 2003 Feb 01; 21(3):421-7. PMID: 12560429.
      Citations: 59     Fields:    Translation:HumansCTClinical Trials
    206. Crane CH, Skibber JM, Feig BW, Vauthey JN, Thames HD, Curley SA, Rodriguez-Bigas MA, Wolff RA, Ellis LM, Delclos ME, Lin EH, Janjan NA. Response to preoperative chemoradiation increases the use of sphincter-preserving surgery in patients with locally advanced low rectal carcinoma. Cancer. 2003 Jan 15; 97(2):517-24. PMID: 12518377.
      Citations: 58     Fields:    Translation:Humans
    207. Ellis LM. A targeted approach for antiangiogenic therapy of metastatic human colon cancer. Am Surg. 2003 Jan; 69(1):3-10. PMID: 12575772.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    208. Ahmad SA, Berman RS, Ellis LM. Biology of colorectal liver metastases. Surg Oncol Clin N Am. 2003 Jan; 12(1):135-50. PMID: 12735135.
      Citations: 7     Fields:    Translation:Humans
    209. Takahashi Y, Ellis LM, Mai M. The angiogenic switch of human colon cancer occurs simultaneous to initiation of invasion. Oncol Rep. 2003 Jan-Feb; 10(1):9-13. PMID: 12469136.
      Citations: 13     Fields:    Translation:Humans
    210. Yoo HG, Shin BA, Park JC, Kim HS, Kim WJ, Chay KO, Ahn BW, Park RK, Ellis LM, Jung YD. Induction of apoptosis by the green tea flavonol (-)-epigallocatechin-3-gallate in human endothelial ECV 304 cells. Anticancer Res. 2002 Nov-Dec; 22(6A):3373-8. PMID: 12530089.
      Citations: 1     Fields:    Translation:HumansCells
    211. Hu M, Nicolson GL, Trent JC, Yu D, Zhang L, Lang A, Killary A, Ellis LM, Bucana CD, Pollock RE. Characterization of 11 human sarcoma cell strains: evaluation of cytogenetics, tumorigenicity, metastasis, and production of angiogenic factors. Cancer. 2002 Oct 01; 95(7):1569-76. PMID: 12237927.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    212. Reinmuth N, Fan F, Liu W, Parikh AA, Stoeltzing O, Jung YD, Bucana CD, Radinsky R, Gallick GE, Ellis LM. Impact of insulin-like growth factor receptor-I function on angiogenesis, growth, and metastasis of colon cancer. Lab Invest. 2002 Oct; 82(10):1377-89. PMID: 12379772.
      Citations: 58     Fields:    Translation:HumansCells
    213. Herbst RS, Hess KR, Tran HT, Tseng JE, Mullani NA, Charnsangavej C, Madden T, Davis DW, McConkey DJ, O'Reilly MS, Ellis LM, Pluda J, Hong WK, Abbruzzese JL. Phase I study of recombinant human endostatin in patients with advanced solid tumors. J Clin Oncol. 2002 Sep 15; 20(18):3792-803. PMID: 12228199.
      Citations: 55     Fields:    Translation:HumansCTClinical Trials
    214. Herbst RS, Mullani NA, Davis DW, Hess KR, McConkey DJ, Charnsangavej C, O'Reilly MS, Kim HW, Baker C, Roach J, Ellis LM, Rashid A, Pluda J, Bucana C, Madden TL, Tran HT, Abbruzzese JL. Development of biologic markers of response and assessment of antiangiogenic activity in a clinical trial of human recombinant endostatin. J Clin Oncol. 2002 Sep 15; 20(18):3804-14. PMID: 12228200.
      Citations: 37     Fields:    Translation:HumansCTClinical Trials
    215. Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene. 2002 Sep 12; 21(41):6278-88. PMID: 12214268.
      Citations: 12     Fields:    Translation:HumansCells
    216. Sartippour MR, Shao ZM, Heber D, Beatty P, Zhang L, Liu C, Ellis L, Liu W, Go VL, Brooks MN. Green tea inhibits vascular endothelial growth factor (VEGF) induction in human breast cancer cells. J Nutr. 2002 Aug; 132(8):2307-11. PMID: 12163680.
      Citations: 73     Fields:    Translation:HumansCells
    217. Takeda A, Stoeltzing O, Ahmad SA, Reinmuth N, Liu W, Parikh A, Fan F, Akagi M, Ellis LM. Role of angiogenesis in the development and growth of liver metastasis. Ann Surg Oncol. 2002 Aug; 9(7):610-6. PMID: 12167573.
      Citations: 27     Fields:    Translation:Humans
    218. Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002 Oct 11; 277(41):38205-11. PMID: 12149254.
      Citations: 242     Fields:    Translation:HumansAnimalsCells
    219. Liu W, Reinmuth N, Stoeltzing O, Parikh AA, Fan F, Ahmad SA, Jung YD, Ellis LM. Antiangiogenic therapy targeting factors that enhance endothelial cell survival. Semin Oncol. 2002 Jun; 29(3 Suppl 11):96-103. PMID: 12138403.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    220. Jung YD, Fan F, McConkey DJ, Jean ME, Liu W, Reinmuth N, Stoeltzing O, Ahmad SA, Parikh AA, Mukaida N, Ellis LM. Role of P38 MAPK, AP-1, and NF-kappaB in interleukin-1beta-induced IL-8 expression in human vascular smooth muscle cells. Cytokine. 2002 May 21; 18(4):206-13. PMID: 12126643.
      Citations: 30     Fields:    Translation:HumansCells
    221. Ellis LM, Liu W, Fan F, Jung YD, Reinmuth N, Stoeltzing O, Takeda A, Akagi M, Parikh AA, Ahmad S. Synopsis of angiogenesis inhibitors in oncology. Oncology (Williston Park). 2002 May; 16(5 Suppl 4):14-22. PMID: 12102576.
      Citations: 3     Fields:    Translation:HumansCells
    222. Prewett MC, Hooper AT, Bassi R, Ellis LM, Waksal HW, Hicklin DJ. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res. 2002 May; 8(5):994-1003. PMID: 12006511.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    223. Wayne JD, Lauwers GY, Ikai I, Doherty DA, Belghiti J, Yamaoka Y, Regimbeau JM, Nagorney DM, Do KA, Ellis LM, Curley SA, Pollock RE, Vauthey JN. Preoperative predictors of survival after resection of small hepatocellular carcinomas. Ann Surg. 2002 May; 235(5):722-30; discussion 730-1. PMID: 11981219; PMCID: PMC1422499.
      Citations: 52     Fields:    Translation:Humans
    224. Curley SA, Cusack JC, Tanabe KK, Stoelzing O, Ellis LM. Advances in the treatment of liver tumors. Curr Probl Surg. 2002 May; 39(5):449-571. PMID: 12019420.
      Citations: 11     Fields:    Translation:HumansCells
    225. Jung YD, Ahmad SA, Liu W, Reinmuth N, Parikh A, Stoeltzing O, Fan F, Ellis LM. The role of the microenvironment and intercellular cross-talk in tumor angiogenesis. Semin Cancer Biol. 2002 Apr; 12(2):105-12. PMID: 12027582.
      Citations: 27     Fields:    Translation:HumansCells
    226. Zhang L, Yu D, Hicklin DJ, Hannay JA, Ellis LM, Pollock RE. Combined anti-fetal liver kinase 1 monoclonal antibody and continuous low-dose doxorubicin inhibits angiogenesis and growth of human soft tissue sarcoma xenografts by induction of endothelial cell apoptosis. Cancer Res. 2002 Apr 01; 62(7):2034-42. PMID: 11929822.
      Citations: 30     Fields:    Translation:HumansAnimals
    227. Ellis LM, Ahmad S, Fan F, Liu W, Jung YD, Stoeltzing O, Reinmuth N, Parikh AA. Angiopoietins and their role in colon cancer angiogenesis. Oncology (Williston Park). 2002 Apr; 16(4 Suppl 3):31-5. PMID: 12014866.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    228. Vauthey JN, Lauwers GY, Esnaola NF, Do KA, Belghiti J, Mirza N, Curley SA, Ellis LM, Regimbeau JM, Rashid A, Cleary KR, Nagorney DM. Simplified staging for hepatocellular carcinoma. J Clin Oncol. 2002 Mar 15; 20(6):1527-36. PMID: 11896101.
      Citations: 225     Fields:    Translation:Humans
    229. Esnaola NF, Lauwers GY, Mirza NQ, Nagorney DM, Doherty D, Ikai I, Yamaoka Y, Regimbeau JM, Belghiti J, Curley SA, Ellis LM, Vauthey JN. Predictors of microvascular invasion in patients with hepatocellular carcinoma who are candidates for orthotopic liver transplantation. J Gastrointest Surg. 2002 Mar-Apr; 6(2):224-32; discussion 232. PMID: 11992808.
      Citations: 70     Fields:    Translation:Humans
    230. McCarty ME, Ellis LM. Mechanisms of anti-angiogenic tyrosine kinase inhibition on wound healing--the obvious and not so obvious. Cancer Biol Ther. 2002 Mar-Apr; 1(2):127-9. PMID: 12212612.
      Citations:    Fields:    Translation:HumansAnimals
    231. Liu W, Ahmad SA, Jung YD, Reinmuth N, Fan F, Bucana CD, Ellis LM. Coexpression of ephrin-Bs and their receptors in colon carcinoma. Cancer. 2002 Feb 15; 94(4):934-9. PMID: 11920461.
      Citations: 39     Fields:    Translation:HumansCells
    232. Termuhlen PM, Sweeney-Gotsch BM, Berman RS, Ellis LM, Bucana C, Shen Y, Cleary KR, McConkey DJ. Increased apoptosis in metastatic human colonic adenocarcinomas. Cancer Biol Ther. 2002 Jan-Feb; 1(1):58-63. PMID: 12170764.
      Citations: 5     Fields:    Translation:HumansCells
    233. Nieweg OE. A response to Lee M. Ellis's editorial: A perspective on sentinel lymph node biopsy in colorectal cancer: the race between surgical technology and molecular oncology. Ann Surg Oncol. 2001 Apr; 8(3):271. PMID: 11314947.
      Citations:    Fields:    Translation:Humans
    234. Bryant MS, Sinclair KG, Copeland EM, Ellis LM, Baumgartner TG, Sitren HS. Absorption of a parenteral diet from the peritoneal cavity. Curr Surg. 1987 Sep-Oct; 44(5):382-4. PMID: 3121257.
      Citations:    Fields:    Translation:AnimalsCells
    235. Kilroy RA, Aull LD, Ellis LM. Vascular spasm during heparin-dihydroergotamine prophylaxis. Clin Pharm. 1987 Jul; 6(7):575-7. PMID: 3691005.
      Citations:    Fields:    Translation:Humans
    236. Workup, diagnosis, and treatment of benign hepatic tumors. Cancer Bulletin. 47:385-391.
    237. The Olszewski/Grossbard/Kozuch article reviewed. Oncology. 19.
    238. In reply [4]. Journal of Clinical Oncology. 25:4692.
    239. Intracrine VEGF signaling mediates the activity of prosurvival pathways in human colorectal cancer cells. Cancer Research. 76:3014-3024.
    240. Nutritional support of the critically ill cancer patient. Cancer Bulletin. 44:234-243.
    241. Treatment of life-threatening hemangiomas of childhood. Cancer Bulletin. 47:408-411.
    242. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (Journal of Clinical Investigation (2012) 122, 1 (419) DOI. Journal of Clinical Investigation. 122:419.
    243. Antiangiogenesis. Clinical Advances in Hematology and Oncology. 3:1-3.
    244. The role of vascular endothelial growth factor in renal cancer progression. Nishinihon Journal of Urology. 63:188-192.
    245. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature. 520:697-701.
    246. Integrating molecular oncology into clinical practice. Journal of Clinical Oncology. 23:937-938.
    247. Expression of Vascular Endothelial Growth Factor and Its Receptor, KDR, Correlates with Vascularity, Metastasis, and Proliferation of Human Colon Cancer. Cancer Research. 55:3969-3972.
    248. Resistance to targeted therapies. Clinical Cancer Research. 15:7471-7478.
    249. mBio. 7.
    250. CCR 20th anniversary commentary. Clinical Cancer Research. 21:3578-3580.
    251. Anti-vascular endothelial growth factor therapy. Clinical Colorectal Cancer. 4.
    252. Should bevacizumab be continued beyond progression in colorectal cancer?. Current Colorectal Cancer Reports. 4:139-143.
    253. In Reply. Journal of Clinical Oncology. 27:1918.
    254. VEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cells. Molecular Cancer Research. 13:1274-1282.
    255. Role of prostaglandins in surgically induced enhancement of tumor growth. Surgical Forum. 40:433-435.
    256. Therapy. Nature Reviews Gastroenterology and Hepatology. 13:384-385.
    257. Targeted therapies and surgical issues in gastrointestinal cancers. Targeted Oncology. 3:119-125.
    258. Pathologic complete response in poorly differentiated adenocarcinomas of the appendix. Acta Oncologica. 52:1046-1048.
    259. Mechanisms of action of anti-VEGF therapy. Clinical Advances in Hematology and Oncology. 3:4-5.
    260. MET amplification in metastatic colorectal cancer. Oncotarget. 7:54627-54631.
    261. A framework for improving the quality of research in the biological sciences. mBio. 7.
    262. Regulators of colon cancer angiogenesis. Expert Opinion on Therapeutic Targets. 4:347-359.
    263. Effects of chronic intravenous infusion of prostaglandin E1 or indomethacin on tumor growth and metastasis. Surgical Forum. 39:456-458.
    264. In reply [2]. Journal of Clinical Oncology. 24:2593-2594.
    265. The Role of Microvasculature in Metastasis Formation. 31-62.
    266. Inhibition of vascular endothelial growth factor receptor-1/Wnt/ β-catenin crosstalk leads to tumor cell death. Clinical Cancer Research. 15:7453-7455.
    267. Angiogenesis and anti-angiogenic therapy. Hematology/Oncology Clinics of North America. 18.
    268. Erratum. Current Problems in Surgery. 39:957.
    269. A disintegrin and metalloproteinase domain 17 regulates colorectal cancer stem cells and chemosensitivity via Notch1 signaling. Stem cells translational medicine. 5:331-338.
    270. Simultaneous radiolabel, genetic tagging, and proliferation assays to study the organ distribution and fate of metastatic cells. International Journal of Oncology. 2:895-901.
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