Loading...
Header Logo
Keywords
Last Name
Institution

GIULIO DRAETTA

TitleProfessor
InstitutionMD Anderson
DepartmentGenomic Medicine
vCardDownload vCard

    Collapse ORNG Applications 
    Collapse Verify Publications

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Tu B, Yao J, Ferri-Borgogno S, Zhao J, Chen S, Wang Q, Yan L, Zhou X, Zhu C, Bang S, Chang Q, Bristow CA, Kang Y, Zheng H, Wang H, Fleming JB, Kim M, Heffernan TP, Draetta GF, Pan D, Maitra A, Yao W, Gupta S, Ying H. YAP1 oncogene is a context-specific driver for pancreatic ductal adenocarcinoma. JCI Insight. 2019 Sep 26. PMID: 31557131.
      View in: PubMed
    2. Inoue A, Deem AK, Kopetz S, Heffernan TP, Draetta GF, Carugo A. Current and Future Horizons of Patient-Derived Xenograft Models in Colorectal Cancer Translational Research. Cancers (Basel). 2019 Sep 06; 11(9). PMID: 31500168.
      View in: PubMed
    3. Mottini C, Tomihara H, Carrella D, Lamolinara A, Iezzi M, Huang JK, Amoreo CA, Buglioni S, Manni I, Robinson FS, Minelli R, Kang Y, Fleming JB, Kim MP, Bristow CA, Trisciuoglio D, Iuliano A, Del Bufalo D, di Bernardo D, Melisi D, Draetta GF, Ciliberto G, Carugo A, Cardone L. Predictive signatures inform the effective repurposing of Decitabine to treat K-RAS-dependent Pancreatic Ductal Adenocarcinoma. Cancer Res. 2019 Sep 05. PMID: 31492820.
      View in: PubMed
    4. Liu J, Srinivasan S, Li CY, Ho IL, Rose J, Shaheen M, Wang G, Yao W, Deem A, Bristow C, Hart T, Draetta G. Pooled library screening with multiplexed Cpf1 library. Nat Commun. 2019 Jul 17; 10(1):3144. PMID: 31316073.
      View in: PubMed
    5. Zhang L, Yao Y, Zhang S, Liu Y, Guo H, Ahmed M, Bell T, Zhang H, Han G, Lorence E, Badillo M, Zhou S, Sun Y, Di Francesco ME, Feng N, Haun R, Lan R, Mackintosh SG, Mao X, Song X, Zhang J, Pham LV, Lorenzi PL, Marszalek J, Heffernan T, Draetta G, Jones P, Futreal A, Nomie K, Wang L, Wang M. Metabolic reprogramming toward oxidative phosphorylation identifies a therapeutic target for mantle cell lymphoma. Sci Transl Med. 2019 May 08; 11(491). PMID: 31068440.
      View in: PubMed
    6. Yao W, Rose JL, Wang W, Seth S, Jiang H, Taguchi A, Liu J, Yan L, Kapoor A, Hou P, Chen Z, Wang Q, Nezi L, Xu Z, Yao J, Hu B, Pettazzoni PF, Ho IL, Feng N, Ramamoorthy V, Jiang S, Deng P, Ma GJ, Den P, Tan Z, Zhang SX, Wang H, Wang YA, Deem AK, Fleming JB, Carugo A, Heffernan TP, Maitra A, Viale A, Ying H, Hanash S, DePinho RA, Draetta GF. Syndecan 1 is a critical mediator of macropinocytosis in pancreatic cancer. Nature. 2019 Apr; 568(7752):410-414. PMID: 30918400.
      View in: PubMed
    7. Bast RC, Matulonis UA, Sood AK, Ahmed AA, Amobi AE, Balkwill FR, Wielgos-Bonvallet M, Bowtell DDL, Brenton JD, Brugge JS, Coleman RL, Draetta GF, Doberstein K, Drapkin RI, Eckert MA, Edwards RP, Elias KM, Ennis D, Futreal A, Gershenson DM, Greenberg RA, Huntsman DG, Ji JXY, Kohn EC, Iavarone C, Lengyel ER, Levine DA, Lord CJ, Lu Z, Mills GB, Modugno F, Nelson BH, Odunsi K, Pilsworth JA, Rottapel RK, Powell DJ, Shen L, Shih IM, Spriggs DR, Walton J, Zhang K, Zhang R, Zou L. Critical questions in ovarian cancer research and treatment: Report of an American Association for Cancer Research Special Conference. Cancer. 2019 Jun 15; 125(12):1963-1972. PMID: 30835824.
      View in: PubMed
    8. Carugo A, Minelli R, Sapio L, Soeung M, Carbone F, Robinson FS, Tepper J, Chen Z, Lovisa S, Svelto M, Amin S, Srinivasan S, Del Poggetto E, Loponte S, Puca F, Dey P, Malouf GG, Su X, Li L, Lopez-Terrada D, Rakheja D, Lazar AJ, Netto GJ, Rao P, Sgambato A, Maitra A, Tripathi DN, Walker CL, Karam JA, Heffernan TP, Viale A, Roberts CWM, Msaouel P, Tannir NM, Draetta GF, Genovese G. p53 Is a Master Regulator of Proteostasis in SMARCB1-Deficient Malignant Rhabdoid Tumors. Cancer Cell. 2019 Feb 11; 35(2):204-220.e9. PMID: 30753823.
      View in: PubMed
    9. Seth S, Li CY, Ho IL, Corti D, Loponte S, Sapio L, Del Poggetto E, Yen EY, Robinson FS, Peoples M, Karpinets T, Deem AK, Kumar T, Song X, Jiang S, Kang Y, Fleming J, Kim M, Zhang J, Maitra A, Heffernan TP, Giuliani V, Genovese G, Futreal A, Draetta GF, Carugo A, Viale A. Pre-existing Functional Heterogeneity of Tumorigenic Compartment as the Origin of Chemoresistance in Pancreatic Tumors. Cell Rep. 2019 Feb 05; 26(6):1518-1532.e9. PMID: 30726735.
      View in: PubMed
    10. Sun Y, Bandi M, Lofton T, Smith M, Bristow CA, Carugo A, Rogers N, Leonard P, Chang Q, Mullinax R, Han J, Shi X, Seth S, Meyers BA, Miller M, Miao L, Ma X, Feng N, Giuliani V, Geck Do M, Czako B, Palmer WS, Mseeh F, Asara JM, Jiang Y, Morlacchi P, Zhao S, Peoples M, Tieu TN, Warmoes MO, Lorenzi PL, Muller FL, DePinho RA, Draetta GF, Toniatti C, Jones P, Heffernan TP, Marszalek JR. Functional Genomics Reveals Synthetic Lethality between Phosphogluconate Dehydrogenase and Oxidative Phosphorylation. Cell Rep. 2019 01 08; 26(2):469-482.e5. PMID: 30625329.
      View in: PubMed
    11. Echeverria GV, Powell E, Seth S, Ge Z, Carugo A, Bristow C, Peoples M, Robinson F, Qiu H, Shao J, Jeter-Jones SL, Zhang X, Ramamoorthy V, Cai S, Wu W, Draetta G, Moulder SL, Symmans WF, Chang JT, Heffernan TP, Piwnica-Worms H. High-resolution clonal mapping of multi-organ metastasis in triple negative breast cancer. Nat Commun. 2018 11 29; 9(1):5079. PMID: 30498242.
      View in: PubMed
    12. Molina JR, Sun Y, Protopopova M, Gera S, Bandi M, Bristow C, McAfoos T, Morlacchi P, Ackroyd J, Agip AA, Al-Atrash G, Asara J, Bardenhagen J, Carrillo CC, Carroll C, Chang E, Ciurea S, Cross JB, Czako B, Deem A, Daver N, de Groot JF, Dong JW, Feng N, Gao G, Gay J, Do MG, Greer J, Giuliani V, Han J, Han L, Henry VK, Hirst J, Huang S, Jiang Y, Kang Z, Khor T, Konoplev S, Lin YH, Liu G, Lodi A, Lofton T, Ma H, Mahendra M, Matre P, Mullinax R, Peoples M, Petrocchi A, Rodriguez-Canale J, Serreli R, Shi T, Smith M, Tabe Y, Theroff J, Tiziani S, Xu Q, Zhang Q, Muller F, DePinho RA, Toniatti C, Draetta GF, Heffernan TP, Konopleva M, Jones P, Di Francesco ME, Marszalek JR. An inhibitor of oxidative phosphorylation exploits cancer vulnerability. Nat Med. 2018 07; 24(7):1036-1046. PMID: 29892070.
      View in: PubMed
    13. Carugo A, Draetta GF. Collapsing the Tumor Ecosystem: Preventing Adaptive Response to Treatment by Inhibiting Transcription. Cancer Discov. 2018 01; 8(1):17-19. PMID: 29311224.
      View in: PubMed
    14. Jaffee EM, Dang CV, Agus DB, Alexander BM, Anderson KC, Ashworth A, Barker AD, Bastani R, Bhatia S, Bluestone JA, Brawley O, Butte AJ, Coit DG, Davidson NE, Davis M, DePinho RA, Diasio RB, Draetta G, Frazier AL, Futreal A, Gambhir SS, Ganz PA, Garraway L, Gerson S, Gupta S, Heath J, Hoffman RI, Hudis C, Hughes-Halbert C, Ibrahim R, Jadvar H, Kavanagh B, Kittles R, Le QT, Lippman SM, Mankoff D, Mardis ER, Mayer DK, McMasters K, Meropol NJ, Mitchell B, Naredi P, Ornish D, Pawlik TM, Peppercorn J, Pomper MG, Raghavan D, Ritchie C, Schwarz SW, Sullivan R, Wahl R, Wolchok JD, Wong SL, Yung A. Future cancer research priorities in the USA: a Lancet Oncology Commission. Lancet Oncol. 2017 11; 18(11):e653-e706. PMID: 29208398.
      View in: PubMed
    15. Adelaiye-Ogala R, Budka J, Damayanti NP, Arrington J, Ferris M, Hsu CC, Chintala S, Orillion A, Miles KM, Shen L, Elbanna M, Ciamporcero E, Arisa S, Pettazzoni P, Draetta GF, Seshadri M, Hancock B, Radovich M, Kota J, Buck M, Keilhack H, McCarthy BP, Persohn SA, Territo PR, Zang Y, Irudayaraj J, Tao WA, Hollenhorst P, Pili R. EZH2 Modifies Sunitinib Resistance in Renal Cell Carcinoma by Kinome Reprogramming. Cancer Res. 2017 12 01; 77(23):6651-6666. PMID: 28978636.
      View in: PubMed
    16. Marchesini M, Ogoti Y, Fiorini E, Aktas Samur A, Nezi L, D'Anca M, Storti P, Samur MK, Ganan-Gomez I, Fulciniti MT, Mistry N, Jiang S, Bao N, Marchica V, Neri A, Bueso-Ramos C, Wu CJ, Zhang L, Liang H, Peng X, Giuliani N, Draetta G, Clise-Dwyer K, Kantarjian H, Munshi N, Orlowski R, Garcia-Manero G, DePinho RA, Colla S. ILF2 Is a Regulator of RNA Splicing and DNA Damage Response in 1q21-Amplified Multiple Myeloma. Cancer Cell. 2017 07 10; 32(1):88-100.e6. PMID: 28669490.
      View in: PubMed
    17. Sarkar S, Bristow CA, Dey P, Rai K, Perets R, Ramirez-Cardenas A, Malasi S, Huang-Hobbs E, Haemmerle M, Wu SY, McGuire M, Protopopov A, Jiang S, Liu JF, Hirsch MS, Chang Q, Lazar AJ, Sood AK, Drapkin R, DePinho R, Draetta G, Chin L. PRKCI promotes immune suppression in ovarian cancer. Genes Dev. 2017 06 01; 31(11):1109-1121. PMID: 28698296.
      View in: PubMed
    18. Workman P, Draetta GF, Schellens JHM, Bernards R. How Much Longer Will We Put Up With $100,000 Cancer Drugs? Cell. 2017 02 09; 168(4):579-583. PMID: 28187281.
      View in: PubMed
    19. Genovese G, Carugo A, Tepper J, Robinson FS, Li L, Svelto M, Nezi L, Corti D, Minelli R, Pettazzoni P, Gutschner T, Wu CC, Seth S, Akdemir KC, Leo E, Amin S, Molin MD, Ying H, Kwong LN, Colla S, Takahashi K, Ghosh P, Giuliani V, Muller F, Dey P, Jiang S, Garvey J, Liu CG, Zhang J, Heffernan TP, Toniatti C, Fleming JB, Goggins MG, Wood LD, Sgambato A, Agaimy A, Maitra A, Roberts CW, Wang H, Viale A, DePinho RA, Draetta GF, Chin L. Synthetic vulnerabilities of mesenchymal subpopulations in pancreatic cancer. Nature. 2017 02 16; 542(7641):362-366. PMID: 28178232.
      View in: PubMed
    20. Dey P, Baddour J, Muller F, Wu CC, Wang H, Liao WT, Lan Z, Chen A, Gutschner T, Kang Y, Fleming J, Satani N, Zhao D, Achreja A, Yang L, Lee J, Chang E, Genovese G, Viale A, Ying H, Draetta G, Maitra A, Wang YA, Nagrath D, DePinho RA. Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer. Nature. 2017 02 02; 542(7639):119-123. PMID: 28099419.
      View in: PubMed
    21. Carugo A, Genovese G, Seth S, Nezi L, Rose JL, Bossi D, Cicalese A, Shah PK, Viale A, Pettazzoni PF, Akdemir KC, Bristow CA, Robinson FS, Tepper J, Sanchez N, Gupta S, Estecio MR, Giuliani V, Dellino GI, Riva L, Yao W, Di Francesco ME, Green T, D'Alesio C, Corti D, Kang Y, Jones P, Wang H, Fleming JB, Maitra A, Pelicci PG, Chin L, DePinho RA, Lanfrancone L, Heffernan TP, Draetta GF. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Rep. 2016 06 28; 16(1):133-147. PMID: 27320920.
      View in: PubMed
    22. Bossi D, Cicalese A, Dellino GI, Luzi L, Riva L, D'Alesio C, Diaferia GR, Carugo A, Cavallaro E, Piccioni R, Barberis M, Mazzarol G, Testori A, Punzi S, Pallavicini I, Tosti G, Giacó L, Melloni G, Heffernan TP, Natoli G, Draetta GF, Minucci S, Pelicci P, Lanfrancone L. In Vivo Genetic Screens of Patient-Derived Tumors Revealed Unexpected Frailty of the Transformed Phenotype. Cancer Discov. 2016 06; 6(6):650-63. PMID: 27179036.
      View in: PubMed
    23. Ying H, Dey P, Yao W, Kimmelman AC, Draetta GF, Maitra A, DePinho RA. Genetics and biology of pancreatic ductal adenocarcinoma. Genes Dev. 2016 Feb 15; 30(4):355-85. PMID: 26883357.
      View in: PubMed
    24. Petrocchi A, Leo E, Reyna NJ, Hamilton MM, Shi X, Parker CA, Mseeh F, Bardenhagen JP, Leonard P, Cross JB, Huang S, Jiang Y, Cardozo M, Draetta G, Marszalek JR, Toniatti C, Jones P, Lewis RT. Identification of potent and selective MTH1 inhibitors. Bioorg Med Chem Lett. 2016 Mar 15; 26(6):1503-1507. PMID: 26898335.
      View in: PubMed
    25. Gutschner T, Haemmerle M, Genovese G, Draetta GF, Chin L. Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair. Cell Rep. 2016 Feb 16; 14(6):1555-1566. PMID: 26854237.
      View in: PubMed
    26. Viale A, Draetta GF. Metabolic Features of Cancer Treatment Resistance. Recent Results Cancer Res. 2016; 207:135-56. PMID: 27557537.
      View in: PubMed
    27. Viale A, Draetta GF. Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells. Cell Metab. 2015 Oct 06; 22(4):543-5. PMID: 26445511.
      View in: PubMed
    28. Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics Chromatin. 2015; 8:37. PMID: 26396593.
      View in: PubMed
    29. Viale A, Corti D, Draetta GF. Tumors and mitochondrial respiration: a neglected connection. Cancer Res. 2015 Sep 15; 75(18):3685-6. PMID: 26374463.
      View in: PubMed
    30. Palmer WS, Poncet-Montange G, Liu G, Petrocchi A, Reyna N, Subramanian G, Theroff J, Yau A, Kost-Alimova M, Bardenhagen JP, Leo E, Shepard HE, Tieu TN, Shi X, Zhan Y, Zhao S, Barton MC, Draetta G, Toniatti C, Jones P, Geck Do M, Andersen JN. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25; 59(4):1440-54. PMID: 26061247.
      View in: PubMed
    31. Vangamudi B, Paul TA, Shah PK, Kost-Alimova M, Nottebaum L, Shi X, Zhan Y, Leo E, Mahadeshwar HS, Protopopov A, Futreal A, Tieu TN, Peoples M, Heffernan TP, Marszalek JR, Toniatti C, Petrocchi A, Verhelle D, Owen DR, Draetta G, Jones P, Palmer WS, Sharma S, Andersen JN. The SMARCA2/4 ATPase Domain Surpasses the Bromodomain as a Drug Target in SWI/SNF-Mutant Cancers: Insights from cDNA Rescue and PFI-3 Inhibitor Studies. Cancer Res. 2015 Sep 15; 75(18):3865-3878. PMID: 26139243.
      View in: PubMed
    32. Chiaradonna F, Barozzi I, Miccolo C, Bucci G, Palorini R, Fornasari L, Botrugno OA, Pruneri G, Masullo M, Passafaro A, Galimberti VE, Fantin VR, Richon VM, Pece S, Viale G, Di Fiore PP, Draetta G, Pelicci PG, Minucci S, Chiocca S. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Antioxid Redox Signal. 2015 Jul 01; 23(1):15-29. PMID: 25897982.
      View in: PubMed
    33. Pettazzoni P, Viale A, Shah P, Carugo A, Ying H, Wang H, Genovese G, Seth S, Minelli R, Green T, Huang-Hobbs E, Corti D, Sanchez N, Nezi L, Marchesini M, Kapoor A, Yao W, Francesco ME, Petrocchi A, Deem AK, Scott K, Colla S, Mills GB, Fleming JB, Heffernan TP, Jones P, Toniatti C, DePinho RA, Draetta GF. Genetic events that limit the efficacy of MEK and RTK inhibitor therapies in a mouse model of KRAS-driven pancreatic cancer. Cancer Res. 2015 Mar 15; 75(6):1091-101. PMID: 25736685.
      View in: PubMed
    34. Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sánchez N, Marchesini M, Carugo A, Green T, Seth S, Giuliani V, Kost-Alimova M, Muller F, Colla S, Nezi L, Genovese G, Deem AK, Kapoor A, Yao W, Brunetto E, Kang Y, Yuan M, Asara JM, Wang YA, Heffernan TP, Kimmelman AC, Wang H, Fleming JB, Cantley LC, DePinho RA, Draetta GF. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature. 2014 Oct 30; 514(7524):628-32. PMID: 25119024.
      View in: PubMed
    35. Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, Zhong Y, Wu CJ, Sadanandam A, Hu B, Chang Q, Chu GC, Al-Khalil R, Jiang S, Xia H, Fletcher-Sananikone E, Lim C, Horwitz GI, Viale A, Pettazzoni P, Sanchez N, Wang H, Protopopov A, Zhang J, Heffernan T, Johnson RL, Chin L, Wang YA, Draetta G, DePinho RA. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell. 2014 Jul 03; 158(1):185-197. PMID: 24954535.
      View in: PubMed
    36. Toniatti C, Jones P, Graham H, Pagliara B, Draetta G. Oncology drug discovery: planning a turnaround. Cancer Discov. 2014 Apr; 4(4):397-404. PMID: 24706659.
      View in: PubMed
    37. Berman DM, Bosenberg MW, Orwant RL, Thurberg BL, Draetta GF, Fletcher CD, Loda M. Investigative pathology: leading the post-genomic revolution. Lab Invest. 2012 Jan; 92(1):4-8. PMID: 21986811.
      View in: PubMed
    38. Draetta GF, Depinho RA. Cancer drug discovery faces the FACT. Sci Transl Med. 2011 Aug 10; 3(95):95ps34. PMID: 21832237.
      View in: PubMed
    39. Ellwood-Yen K, Keilhack H, Kunii K, Dolinski B, Connor Y, Hu K, Nagashima K, O'Hare E, Erkul Y, Di Bacco A, Gargano D, Shomer NH, Angagaw M, Leccese E, Andrade P, Hurd M, Shin MK, Vogt TF, Northrup A, Bobkova EV, Kasibhatla S, Bronson RT, Scott ML, Draetta G, Richon V, Kohl N, Blume-Jensen P, Andersen JN, Kraus M. PDK1 attenuation fails to prevent tumor formation in PTEN-deficient transgenic mouse models. Cancer Res. 2011 Apr 15; 71(8):3052-65. PMID: 21493594.
      View in: PubMed
    40. Benedettini E, Sholl LM, Peyton M, Reilly J, Ware C, Davis L, Vena N, Bailey D, Yeap BY, Fiorentino M, Ligon AH, Pan BS, Richon V, Minna JD, Gazdar AF, Draetta G, Bosari S, Chirieac LR, Lutterbach B, Loda M. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol. 2010 Jul; 177(1):415-23. PMID: 20489150.
      View in: PubMed
    41. Efferson CL, Winkelmann CT, Ware C, Sullivan T, Giampaoli S, Tammam J, Patel S, Mesiti G, Reilly JF, Gibson RE, Buser C, Yeatman T, Coppola D, Winter C, Clark EA, Draetta GF, Strack PR, Majumder PK. Downregulation of Notch pathway by a gamma-secretase inhibitor attenuates AKT/mammalian target of rapamycin signaling and glucose uptake in an ERBB2 transgenic breast cancer model. Cancer Res. 2010 Mar 15; 70(6):2476-84. PMID: 20197467.
      View in: PubMed
    42. Tammam J, Ware C, Efferson C, O'Neil J, Rao S, Qu X, Gorenstein J, Angagaw M, Kim H, Kenific C, Kunii K, Leach KJ, Nikov G, Zhao J, Dai X, Hardwick J, Scott M, Winter C, Bristow L, Elbi C, Reilly JF, Look T, Draetta G, Van der Ploeg L, Kohl NE, Strack PR, Majumder PK. Down-regulation of the Notch pathway mediated by a gamma-secretase inhibitor induces anti-tumour effects in mouse models of T-cell leukaemia. Br J Pharmacol. 2009 Nov; 158(5):1183-95. PMID: 19775282.
      View in: PubMed
    43. Rao SS, O'Neil J, Liberator CD, Hardwick JS, Dai X, Zhang T, Tyminski E, Yuan J, Kohl NE, Richon VM, Van der Ploeg LH, Carroll PM, Draetta GF, Look AT, Strack PR, Winter CG. Inhibition of NOTCH signaling by gamma secretase inhibitor engages the RB pathway and elicits cell cycle exit in T-cell acute lymphoblastic leukemia cells. Cancer Res. 2009 Apr 01; 69(7):3060-8. PMID: 19318552.
      View in: PubMed
    44. O'Neil J, Grim J, Strack P, Rao S, Tibbitts D, Winter C, Hardwick J, Welcker M, Meijerink JP, Pieters R, Draetta G, Sears R, Clurman BE, Look AT. FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to gamma-secretase inhibitors. J Exp Med. 2007 Aug 06; 204(8):1813-24. PMID: 17646409.
      View in: PubMed
    45. Senese S, Zaragoza K, Minardi S, Muradore I, Ronzoni S, Passafaro A, Bernard L, Draetta GF, Alcalay M, Seiser C, Chiocca S. Role for histone deacetylase 1 in human tumor cell proliferation. Mol Cell Biol. 2007 Jul; 27(13):4784-95. PMID: 17470557.
      View in: PubMed
    46. Busino L, Bassermann F, Maiolica A, Lee C, Nolan PM, Godinho SI, Draetta GF, Pagano M. SCFFbxl3 controls the oscillation of the circadian clock by directing the degradation of cryptochrome proteins. Science. 2007 May 11; 316(5826):900-4. PMID: 17463251.
      View in: PubMed
    47. Lewis HD, Leveridge M, Strack PR, Haldon CD, O'neil J, Kim H, Madin A, Hannam JC, Look AT, Kohl N, Draetta G, Harrison T, Kerby JA, Shearman MS, Beher D. Apoptosis in T cell acute lymphoblastic leukemia cells after cell cycle arrest induced by pharmacological inhibition of notch signaling. Chem Biol. 2007 Feb; 14(2):209-19. PMID: 17317574.
      View in: PubMed
    48. Capra M, Nuciforo PG, Confalonieri S, Quarto M, Bianchi M, Nebuloni M, Boldorini R, Pallotti F, Viale G, Gishizky ML, Draetta GF, Di Fiore PP. Frequent alterations in the expression of serine/threonine kinases in human cancers. Cancer Res. 2006 Aug 15; 66(16):8147-54. PMID: 16912193.
      View in: PubMed
    49. Squatrito M, Mancino M, Sala L, Draetta GF. Ebp1 is a dsRNA-binding protein associated with ribosomes that modulates eIF2alpha phosphorylation. Biochem Biophys Res Commun. 2006 Jun 09; 344(3):859-68. PMID: 16631606.
      View in: PubMed
    50. Draetta GF. Commentary on "A new cancer diagnostic system based on a CDK profiling technology" [Biochim. Biophys. Acta Molecular Basis of Disease 1741 (2005) 226-233]. Biochim Biophys Acta. 2005 Sep 25; 1741(3):225. PMID: 16183014.
      View in: PubMed
    51. Ray D, Terao Y, Nimbalkar D, Chu LH, Donzelli M, Tsutsui T, Zou X, Ghosh AK, Varga J, Draetta GF, Kiyokawa H. Transforming growth factor beta facilitates beta-TrCP-mediated degradation of Cdc25A in a Smad3-dependent manner. Mol Cell Biol. 2005 Apr; 25(8):3338-47. PMID: 15798217.
      View in: PubMed
    52. Boggio R, Colombo R, Hay RT, Draetta GF, Chiocca S. A mechanism for inhibiting the SUMO pathway. Mol Cell. 2004 Nov 19; 16(4):549-61. PMID: 15546615.
      View in: PubMed
    53. Masciadri B, Areces LB, Carpinelli P, Foiani M, Draetta G, Fiore F. Characterization of the BUD31 gene of Saccharomyces cerevisiae. Biochem Biophys Res Commun. 2004 Aug 06; 320(4):1342-50. PMID: 15303280.
      View in: PubMed
    54. Squatrito M, Mancino M, Donzelli M, Areces LB, Draetta GF. EBP1 is a nucleolar growth-regulating protein that is part of pre-ribosomal ribonucleoprotein complexes. Oncogene. 2004 May 27; 23(25):4454-65. PMID: 15064750.
      View in: PubMed
    55. Donzelli M, Busino L, Chiesa M, Ganoth D, Hershko A, Draetta GF. Hierarchical order of phosphorylation events commits Cdc25A to betaTrCP-dependent degradation. Cell Cycle. 2004 Apr; 3(4):469-71. PMID: 14752276.
      View in: PubMed
    56. Busino L, Chiesa M, Draetta GF, Donzelli M. Cdc25A phosphatase: combinatorial phosphorylation, ubiquitylation and proteolysis. Oncogene. 2004 Mar 15; 23(11):2050-6. PMID: 15021892.
      View in: PubMed
    57. Busino L, Donzelli M, Chiesa M, Guardavaccaro D, Ganoth D, Dorrello NV, Hershko A, Pagano M, Draetta GF. Degradation of Cdc25A by beta-TrCP during S phase and in response to DNA damage. Nature. 2003 Nov 06; 426(6962):87-91. PMID: 14603323.
      View in: PubMed
    58. Donzelli M, Draetta GF. Regulating mammalian checkpoints through Cdc25 inactivation. EMBO Rep. 2003 Jul; 4(7):671-7. PMID: 12835754.
      View in: PubMed
    59. Colombo R, Draetta GF, Chiocca S. Modulation of p120E4F transcriptional activity by the Gam1 adenoviral early protein. Oncogene. 2003 May 01; 22(17):2541-7. PMID: 12730668.
      View in: PubMed
    60. Colombo R, Boggio R, Seiser C, Draetta GF, Chiocca S. The adenovirus protein Gam1 interferes with sumoylation of histone deacetylase 1. EMBO Rep. 2002 Nov; 3(11):1062-8. PMID: 12393750.
      View in: PubMed
    61. Donzelli M, Squatrito M, Ganoth D, Hershko A, Pagano M, Draetta GF. Dual mode of degradation of Cdc25 A phosphatase. EMBO J. 2002 Sep 16; 21(18):4875-84. PMID: 12234927.
      View in: PubMed
    62. Chiocca S, Kurtev V, Colombo R, Boggio R, Sciurpi MT, Brosch G, Seiser C, Draetta GF, Cotten M. Histone deacetylase 1 inactivation by an adenovirus early gene product. Curr Biol. 2002 Apr 02; 12(7):594-8. PMID: 11937030.
      View in: PubMed
    63. Rodier G, Montagnoli A, Di Marcotullio L, Coulombe P, Draetta GF, Pagano M, Meloche S. p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis. EMBO J. 2001 Dec 03; 20(23):6672-82. PMID: 11726503.
      View in: PubMed
    64. Soncini C, Berdo I, Draetta G. Ras-GAP SH3 domain binding protein (G3BP) is a modulator of USP10, a novel human ubiquitin specific protease. Oncogene. 2001 Jun 28; 20(29):3869-79. PMID: 11439350.
      View in: PubMed
    65. Molinari M, Mercurio C, Dominguez J, Goubin F, Draetta GF. Human Cdc25 A inactivation in response to S phase inhibition and its role in preventing premature mitosis. EMBO Rep. 2000 Jul; 1(1):71-9. PMID: 11256629.
      View in: PubMed
    66. Piva R, Cancelli I, Cavalla P, Bortolotto S, Dominguez J, Draetta GF, Schiffer D. Proteasome-dependent degradation of p27/kip1 in gliomas. J Neuropathol Exp Neurol. 1999 Jul; 58(7):691-6. PMID: 10411338.
      View in: PubMed
    67. Montagnoli A, Fiore F, Eytan E, Carrano AC, Draetta GF, Hershko A, Pagano M. Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev. 1999 May 01; 13(9):1181-9. PMID: 10323868.
      View in: PubMed
    68. Thomas GV, Szigeti K, Murphy M, Draetta G, Pagano M, Loda M. Down-regulation of p27 is associated with development of colorectal adenocarcinoma metastases. Am J Pathol. 1998 Sep; 153(3):681-7. PMID: 9736017.
      View in: PubMed
    69. Naviglio S, Mattecucci C, Matoskova B, Nagase T, Nomura N, Di Fiore PP, Draetta GF. UBPY: a growth-regulated human ubiquitin isopeptidase. EMBO J. 1998 Jun 15; 17(12):3241-50. PMID: 9628861.
      View in: PubMed
    70. Draetta GF. 11th European Cell Cycle Conference: April 23-26, 1997, Gardone Riviera (Italy) and Symposium on Cell Cycle Regulation (17th International Congress of Biochemistry and Molecular Biology): August 24-29, 1997, San Francisco, CA. Biochim Biophys Acta. 1998 Feb 20; 1377(1):R11-20. PMID: 9540812.
      View in: PubMed
    71. Lamphere L, Fiore F, Xu X, Brizuela L, Keezer S, Sardet C, Draetta GF, Gyuris J. Interaction between Cdc37 and Cdk4 in human cells. Oncogene. 1997 Apr 24; 14(16):1999-2004. PMID: 9150368.
      View in: PubMed
    72. Draetta G, Eckstein J. Cdc25 protein phosphatases in cell proliferation. Biochim Biophys Acta. 1997 Apr 18; 1332(2):M53-63. PMID: 9141461.
      View in: PubMed
    73. Tan P, Cady B, Wanner M, Worland P, Cukor B, Magi-Galluzzi C, Lavin P, Draetta G, Pagano M, Loda M. The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a,b) invasive breast carcinomas. Cancer Res. 1997 Apr 01; 57(7):1259-63. PMID: 9102210.
      View in: PubMed
    74. Loda M, Cukor B, Tam SW, Lavin P, Fiorentino M, Draetta GF, Jessup JM, Pagano M. Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas. Nat Med. 1997 Feb; 3(2):231-4. PMID: 9018245.
      View in: PubMed
    75. Draetta GF. Cell cycle: will the real Cdk-activating kinase please stand up. Curr Biol. 1997 Jan 01; 7(1):R50-2. PMID: 9072172.
      View in: PubMed
    76. Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M, Beach D. CDC25 phosphatases as potential human oncogenes. Science. 1995 Sep 15; 269(5230):1575-7. PMID: 7667636.
      View in: PubMed
    77. Pagano M, Tam SW, Theodoras AM, Beer-Romero P, Del Sal G, Chau V, Yew PR, Draetta GF, Rolfe M. Role of the ubiquitin-proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27. Science. 1995 Aug 04; 269(5224):682-5. PMID: 7624798.
      View in: PubMed
    78. Rolfe M, Beer-Romero P, Glass S, Eckstein J, Berdo I, Theodoras A, Pagano M, Draetta G. Reconstitution of p53-ubiquitinylation reactions from purified components: the role of human ubiquitin-conjugating enzyme UBC4 and E6-associated protein (E6AP). Proc Natl Acad Sci U S A. 1995 Apr 11; 92(8):3264-8. PMID: 7724550.
      View in: PubMed
    79. Basi G, Draetta G. p13suc1 of Schizosaccharomyces pombe regulates two distinct forms of the mitotic cdc2 kinase. Mol Cell Biol. 1995 Apr; 15(4):2028-36. PMID: 7891698.
      View in: PubMed
    80. Draetta GF. Mammalian G1 cyclins. Curr Opin Cell Biol. 1994 Dec; 6(6):842-6. PMID: 7880531.
      View in: PubMed
    81. Brambilla R, Draetta G. Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases. Oncogene. 1994 Oct; 9(10):3037-41. PMID: 8084611.
      View in: PubMed
    82. O'Connor PM, Ferris DK, Hoffmann I, Jackman J, Draetta G, Kohn KW. Role of the cdc25C phosphatase in G2 arrest induced by nitrogen mustard. Proc Natl Acad Sci U S A. 1994 Sep 27; 91(20):9480-4. PMID: 7937793.
      View in: PubMed
    83. Hoffmann I, Draetta G, Karsenti E. Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 1994 Sep 15; 13(18):4302-10. PMID: 7523110.
      View in: PubMed
    84. Tam SW, Theodoras AM, Shay JW, Draetta GF, Pagano M. Differential expression and regulation of Cyclin D1 protein in normal and tumor human cells: association with Cdk4 is required for Cyclin D1 function in G1 progression. Oncogene. 1994 Sep; 9(9):2663-74. PMID: 8058330.
      View in: PubMed
    85. Pagano M, Theodoras AM, Tam SW, Draetta GF. Cyclin D1-mediated inhibition of repair and replicative DNA synthesis in human fibroblasts. Genes Dev. 1994 Jul 15; 8(14):1627-39. PMID: 7958844.
      View in: PubMed
    86. Lukas J, Pagano M, Staskova Z, Draetta G, Bartek J. Cyclin D1 protein oscillates and is essential for cell cycle progression in human tumour cell lines. Oncogene. 1994 Mar; 9(3):707-18. PMID: 8108113.
      View in: PubMed
    87. Roussou I, Draetta G. The Schizosaccharomyces pombe casein kinase II alpha and beta subunits: evolutionary conservation and positive role of the beta subunit. Mol Cell Biol. 1994 Jan; 14(1):576-86. PMID: 8264625.
      View in: PubMed
    88. Draetta G. Cdc2 activation: the interplay of cyclin binding and Thr161 phosphorylation. Trends Cell Biol. 1993 Sep; 3(9):287-9. PMID: 14731844.
      View in: PubMed
    89. Marcote MJ, Knighton DR, Basi G, Sowadski JM, Brambilla P, Draetta G, Taylor SS. A three-dimensional model of the Cdc2 protein kinase: localization of cyclin- and Suc1-binding regions and phosphorylation sites. Mol Cell Biol. 1993 Aug; 13(8):5122-31. PMID: 8336738.
      View in: PubMed
    90. Superti-Furga G, Fumagalli S, Koegl M, Courtneidge SA, Draetta G. Csk inhibition of c-Src activity requires both the SH2 and SH3 domains of Src. EMBO J. 1993 Jul; 12(7):2625-34. PMID: 7687537.
      View in: PubMed
    91. Roussou I, Draetta G. Phosphorylation in yeast cell processes. Cell Signal. 1993 Jul; 5(4):381-7. PMID: 8373722.
      View in: PubMed
    92. Bártek J, Stasková Z, Draetta G, Lukás J. Molecular pathology of the cell cycle in human cancer cells. Stem Cells. 1993 May; 11 Suppl 1:51-8. PMID: 8318919.
      View in: PubMed
    93. Baldin V, Lukas J, Marcote MJ, Pagano M, Draetta G. Cyclin D1 is a nuclear protein required for cell cycle progression in G1. Genes Dev. 1993 May; 7(5):812-21. PMID: 8491378.
      View in: PubMed
    94. Jansen-Dürr P, Meichle A, Steiner P, Pagano M, Finke K, Botz J, Wessbecher J, Draetta G, Eilers M. Differential modulation of cyclin gene expression by MYC. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3685-9. PMID: 8386381.
      View in: PubMed
    95. O'Connor PM, Ferris DK, Pagano M, Draetta G, Pines J, Hunter T, Longo DL, Kohn KW. G2 delay induced by nitrogen mustard in human cells affects cyclin A/cdk2 and cyclin B1/cdc2-kinase complexes differently. J Biol Chem. 1993 Apr 15; 268(11):8298-308. PMID: 8463339.
      View in: PubMed
    96. Pagano M, Pepperkok R, Lukas J, Baldin V, Ansorge W, Bartek J, Draetta G. Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts. J Cell Biol. 1993 Apr; 121(1):101-11. PMID: 8458862.
      View in: PubMed
    97. Clarke PR, Hoffmann I, Draetta G, Karsenti E. Dephosphorylation of cdc25-C by a type-2A protein phosphatase: specific regulation during the cell cycle in Xenopus egg extracts. Mol Biol Cell. 1993 Apr; 4(4):397-411. PMID: 8389619.
      View in: PubMed
    98. Hoffmann I, Clarke PR, Marcote MJ, Karsenti E, Draetta G. Phosphorylation and activation of human cdc25-C by cdc2--cyclin B and its involvement in the self-amplification of MPF at mitosis. EMBO J. 1993 Jan; 12(1):53-63. PMID: 8428594.
      View in: PubMed
    99. Pagano M, Dürst M, Joswig S, Draetta G, Jansen-Dürr P. Binding of the human E2F transcription factor to the retinoblastoma protein but not to cyclin A is abolished in HPV-16-immortalized cells. Oncogene. 1992 Sep; 7(9):1681-6. PMID: 1323816.
      View in: PubMed
    100. Landesman Y, Pagano M, Draetta G, Rotter V, Fusenig NE, Kimchi A. Modifications of cell cycle controlling nuclear proteins by transforming growth factor beta in the HaCaT keratinocyte cell line. Oncogene. 1992 Aug; 7(8):1661-5. PMID: 1385861.
      View in: PubMed
    101. Lukás J, Draetta G, Bartek J. Distinct forms of human CDC2 identified by novel monoclonal antibodies. Eur J Biochem. 1992 Jul 01; 207(1):169-76. PMID: 1628647.
      View in: PubMed
    102. Marin O, Meggio F, Draetta G, Pinna LA. The consensus sequences for cdc2 kinase and for casein kinase-2 are mutually incompatible. A study with peptides derived from the beta-subunit of casein kinase-2. FEBS Lett. 1992 Apr 13; 301(1):111-4. PMID: 1451779.
      View in: PubMed
    103. Pagano M, Pepperkok R, Verde F, Ansorge W, Draetta G. Cyclin A is required at two points in the human cell cycle. EMBO J. 1992 Mar; 11(3):961-71. PMID: 1312467.
      View in: PubMed
    104. Buendia B, Draetta G, Karsenti E. Regulation of the microtubule nucleating activity of centrosomes in Xenopus egg extracts: role of cyclin A-associated protein kinase. J Cell Biol. 1992 Mar; 116(6):1431-42. PMID: 1531830.
      View in: PubMed
    105. Pagano M, Draetta G, Jansen-Dürr P. Association of cdk2 kinase with the transcription factor E2F during S phase. Science. 1992 Feb 28; 255(5048):1144-7. PMID: 1312258.
      View in: PubMed
    106. Marcote MJ, Pagano M, Draetta G. cdc2 protein kinase: structure-function relationships. Ciba Found Symp. 1992; 170:30-41; discussion 41-9. PMID: 1483349.
      View in: PubMed
    107. Ducommun B, Brambilla P, Draetta G. Mutations at sites involved in Suc1 binding inactivate Cdc2. Mol Cell Biol. 1991 Dec; 11(12):6177-84. PMID: 1944283.
      View in: PubMed
    108. Ducommun B, Brambilla P, Félix MA, Franza BR, Karsenti E, Draetta G. cdc2 phosphorylation is required for its interaction with cyclin. EMBO J. 1991 Nov; 10(11):3311-9. PMID: 1833185.
      View in: PubMed
    109. Roth SY, Collini MP, Draetta G, Beach D, Allis CD. A cdc2-like kinase phosphorylates histone H1 in the amitotic macronucleus of Tetrahymena. EMBO J. 1991 Aug; 10(8):2069-75. PMID: 2065655.
      View in: PubMed
    110. Wang HG, Draetta G, Moran E. E1A induces phosphorylation of the retinoblastoma protein independently of direct physical association between the E1A and retinoblastoma products. Mol Cell Biol. 1991 Aug; 11(8):4253-65. PMID: 1830128.
      View in: PubMed
    111. Howe PH, Draetta G, Leof EB. Transforming growth factor beta 1 inhibition of p34cdc2 phosphorylation and histone H1 kinase activity is associated with G1/S-phase growth arrest. Mol Cell Biol. 1991 Mar; 11(3):1185-94. PMID: 1996085.
      View in: PubMed
    112. Pagano M, Draetta G. Cyclin A, cell cycle control and oncogenesis. Prog Growth Factor Res. 1991; 3(4):267-77. PMID: 1839823.
      View in: PubMed
    113. Brambilla P, Ducommun B, Draetta G. cdc2 protein kinase: interactions with cyclins and suc1. Cold Spring Harb Symp Quant Biol. 1991; 56:515-21. PMID: 1840262.
      View in: PubMed
    114. Draetta G. Cell cycle control in eukaryotes: molecular mechanisms of cdc2 activation. Trends Biochem Sci. 1990 Oct; 15(10):378-83. PMID: 2147521.
      View in: PubMed
    115. Ducommun B, Draetta G, Young P, Beach D. Fission yeast cdc25 is a cell-cycle regulated protein. Biochem Biophys Res Commun. 1990 Feb 28; 167(1):301-9. PMID: 2178610.
      View in: PubMed
    116. Giordano A, Whyte P, Harlow E, Franza BR, Beach D, Draetta G. A 60 kd cdc2-associated polypeptide complexes with the E1A proteins in adenovirus-infected cells. Cell. 1989 Sep 08; 58(5):981-90. PMID: 2570639.
      View in: PubMed
    117. Morla AO, Draetta G, Beach D, Wang JY. Reversible tyrosine phosphorylation of cdc2: dephosphorylation accompanies activation during entry into mitosis. Cell. 1989 Jul 14; 58(1):193-203. PMID: 2473839.
      View in: PubMed
    118. Brizuela L, Draetta G, Beach D. Activation of human CDC2 protein as a histone H1 kinase is associated with complex formation with the p62 subunit. Proc Natl Acad Sci U S A. 1989 Jun; 86(12):4362-6. PMID: 2543971.
      View in: PubMed
    119. Riabowol K, Draetta G, Brizuela L, Vandre D, Beach D. The cdc2 kinase is a nuclear protein that is essential for mitosis in mammalian cells. Cell. 1989 May 05; 57(3):393-401. PMID: 2541912.
      View in: PubMed
    120. Draetta G, Luca F, Westendorf J, Brizuela L, Ruderman J, Beach D. Cdc2 protein kinase is complexed with both cyclin A and B: evidence for proteolytic inactivation of MPF. Cell. 1989 Mar 10; 56(5):829-38. PMID: 2538242.
      View in: PubMed
    121. Draetta G, Beach D. The mammalian cdc2 protein kinase: mechanisms of regulation during the cell cycle. J Cell Sci Suppl. 1989; 12:21-7. PMID: 2699735.
      View in: PubMed
    122. Draetta G, Piwnica-Worms H, Morrison D, Druker B, Roberts T, Beach D. Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate. Nature. 1988 Dec 22-29; 336(6201):738-44. PMID: 2462672.
      View in: PubMed
    123. Heppel LA, Newton DL, Klee CB, Draetta GF. The phosphorylation of calmodulin and calmodulin fragments by kinase fractions from bovine brain. Biochim Biophys Acta. 1988 Oct 28; 972(1):69-78. PMID: 2846073.
      View in: PubMed
    124. Draetta G, Beach D. Activation of cdc2 protein kinase during mitosis in human cells: cell cycle-dependent phosphorylation and subunit rearrangement. Cell. 1988 Jul 01; 54(1):17-26. PMID: 3289755.
      View in: PubMed
    125. Draetta G, Beach D, Moran E. Synthesis of p34, the mammalian homolog of the yeast cdc2+/CDC28 protein kinase, is stimulated during adenovirus-induced proliferation of primary baby rat kidney cells. Oncogene. 1988 Jun; 2(6):553-7. PMID: 2838787.
      View in: PubMed
    126. Draetta G, Brizuela L, Moran B, Beach D. Regulation of the vertebrate cell cycle by the cdc2 protein kinase. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:195-201. PMID: 3076080.
      View in: PubMed
    127. Draetta G, Klee CB. Purification of calmodulin-stimulated phosphodiesterase by affinity chromatography on calmodulin fragment 1-77 linked to sepharose. Methods Enzymol. 1988; 159:573-81. PMID: 2842620.
      View in: PubMed
    128. Draetta G, Brizuela L, Beach D. p34, a protein kinase involved in cell cycle regulation in eukaryotic cells. Adv Exp Med Biol. 1988; 231:453-7. PMID: 3046250.
      View in: PubMed
    129. Klee CB, Draetta GF, Hubbard MJ. Calcineurin. Adv Enzymol Relat Areas Mol Biol. 1988; 61:149-200. PMID: 2833077.
      View in: PubMed
    130. Brizuela L, Draetta G, Beach D. p13suc1 acts in the fission yeast cell division cycle as a component of the p34cdc2 protein kinase. EMBO J. 1987 Nov; 6(11):3507-14. PMID: 3322810.
      View in: PubMed
    131. Draetta G, Brizuela L, Potashkin J, Beach D. Identification of p34 and p13, human homologs of the cell cycle regulators of fission yeast encoded by cdc2+ and suc1+. Cell. 1987 Jul 17; 50(2):319-25. PMID: 3297353.
      View in: PubMed
    132. Porta R, De Santis A, Esposito C, Draetta GF, Di Donato A, Illiano G. Inhibition of adenylate cyclase by transglutaminase-catalyzed reactions in pigeon erythrocyte ghosts. Biochem Biophys Res Commun. 1986 Jul 31; 138(2):596-603. PMID: 2874804.
      View in: PubMed
    133. Putkey JA, Draetta GF, Slaughter GR, Klee CB, Cohen P, Stull JT, Means AR. Genetically engineered calmodulins differentially activate target enzymes. J Biol Chem. 1986 Jul 25; 261(21):9896-903. PMID: 3460991.
      View in: PubMed
    134. Klee CB, Ni WC, Draetta GF, Newton DL. Different modes of interaction of calmodulin with its target enzymes. J Cardiovasc Pharmacol. 1986; 8 Suppl 8:S52-6. PMID: 2433526.
      View in: PubMed
    135. Di Donato A, Draetta GF, Illiano G, Tufano MA, Sommese L, Galdiero F. Do porins inhibit the macrophage phagocyting activity by stimulating the adenylate cyclase? J Cyclic Nucleotide Protein Phosphor Res. 1986; 11(2):87-97. PMID: 2426319.
      View in: PubMed
    136. Illiano G, Galderisi R, Di Donato A, Paolisso G, Draetta GF. The effects of lidocaine and procainamide on the sarcolemmal membrane high affinity cyclic AMP phosphodiesterase of rat myocardium. Gen Pharmacol. 1985; 16(2):115-9. PMID: 2987079.
      View in: PubMed
    137. Brotzu G, Carta M, Cherchi R, D'Alia G, Deriu IP, Diaz G, Draetta G, Montisci R, Savona G, Testa Riva F. The stereomorphologic disposition of the muscular capillary network. Experimental research into the effect of training, age, arterial insufficiency and chronic treatment with EPL. J Sports Med Phys Fitness. 1984 Mar; 24(1):1-12. PMID: 6471832.
      View in: PubMed
    138. Illiano G, Chiosi E, Draetta GF, Laurenza A. Relationship between the fluidity of the membrane lipids and the activity of the membrane-bound proteins: the effects of lidocaine on the adenylate cyclase activity of rat myocardium. Gen Pharmacol. 1983; 14(6):669-72. PMID: 6662347.
      View in: PubMed
    139. Pisano M, Draetta G, Valdes E, Serra FA, Versace R, Furcas S, Desogus AI. [Hamartochondromas of the lung. Case reports]. Pathologica. 1982 Sep-Oct; 74(1033):623-30. PMID: 7167275.
      View in: PubMed
    140. Utili R, Di Donato A, Draetta G, Paolisso G, Abernathy CO, Illiano G. Endotoxin inhibits the fluoride-stimulated adenylate cyclase activity of rat liver membranes enriched with bile canaliculi. Experientia. 1982 Jul 15; 38(7):831-3. PMID: 7049721.
      View in: PubMed
    141. Faa G, Dessy E, Bucarelli A, Frau G, Zucca G, Draetta G. [Experimental research on the toxicity of PVC administered orally]. Boll Soc Ital Biol Sper. 1981 Apr 30; 57(8):926-8. PMID: 7272069.
      View in: PubMed
    142. Illiano G, Draetta GF, Laurenza A, Spina A, Paolisso G. The effects of polyamines on the cyclic AMP efflux and metabolism in E. coli B cells. Int J Biochem. 1981; 13(6):701-5. PMID: 6266892.
      View in: PubMed
    143. Draetta G, Pintus ML, Santa Cruz G, Pinto G. [Malignant mesenchymal tumors of the larynx]. Pathologica. 1980 Nov-Dec; 72(1022):821-32. PMID: 6270622.
      View in: PubMed
    144. Zucca G, Dessy E, Faa G, Draetta G. [Tumors of the large intestine. Statistical research and histopathological findings]. Minerva Med. 1980 Mar 17; 71(10):709-13. PMID: 6244519.
      View in: PubMed
    145. Genetics and biology of pancreatic ductal adenocarcinoma. Genes and Development. 30:355-385.
    146. Metabolic features of cancer treatment resistance. 135-156.
    147. The behaviour of cyclic AMP in the plasma and urine of psoriatic patients. (Preliminary note). Annali Italiani di Dermatologia Clinica e Sperimentale. 33:11-16.
    148. Antiangiogenic therapy. Molecular Medicine Today. 6:188-189.
    149. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics and Chromatin. 8.
    150. Biology of the Cell. 76:213.
    151. Correlation between the membrane physical state and the post-translational covalent modifications of membrane bound proteins. Italian Journal of Biochemistry. 33.
    152. Identification of potent and selective MTH1 inhibitors. Bioorganic and Medicinal Chemistry Letters. 26:1503-1507.
    153. Activation of rat myocardial adenylate cyclase activity by sulfate anions. Bulletin of Molecular Biology and Medicine. 3:42-53.
    154. In Vivo Functional Platform Targeting Patient-Derived Xenografts Identifies WDR5-Myc Association as a Critical Determinant of Pancreatic Cancer. Cell Reports. 16:133-147.
    155. Tumors and mitochondrial respiration. Cancer Research. 75:3687-3691.
    156. The SMARCA2/4 ATPase domain surpasses the bromodomain as a drug target in SWI/SNF-mutant cancers. Cancer Research. 75:3865-3878.
    157. Redox-Mediated Suberoylanilide Hydroxamic Acid Sensitivity in Breast Cancer. Antioxidants and Redox Signaling. 23:15-29.
    158. The cdc25 Phosphatase. Advances in Molecular and Cell Biology. 13:151-164.
    159. Chapter 25. Cell Cycle Control and Cancer. Annual Reports in Medicinal Chemistry. 31:241-248.
    160. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. Journal of Medicinal Chemistry. 59:1440-1454.
    161. Post-translational Regulation of Cas9 during G1 Enhances Homology-Directed Repair. Cell Reports. 14:1555-1566.
    DRAETTA's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    _
    Co-Authors Expand Description
    _
    Similar People Expand Description
    _
    Same Department Expand Description