TitleAssociate Professor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. den Hollander P, Maddela JJ, Mani SA. Spatial and Temporal Relationship between Epithelial-Mesenchymal Transition (EMT) and Stem Cells in Cancer. Clin Chem. 2024 01 04; 70(1):190-205. PMID: 38175600.
      Citations:    Fields:    
    2. Kuburich NA, den Hollander P, Castaneda M, Pietil? M, Tang X, Batra H, Mart?nez-Pe?a F, Visal TH, Zhou T, Demestichas BR, Dontula RV, Liu JY, Maddela JJ, Padmanabhan RS, Phi LTH, Rosolen MJ, Sabapathy T, Kumar D, Giancotti FG, Lairson LL, Raso MG, Soundararajan R, Mani SA. Stabilizing vimentin phosphorylation inhibits stem-like cell properties and metastasis of hybrid epithelial/mesenchymal carcinomas. Cell Rep. 2023 12 26; 42(12):113470. PMID: 37979166.
      Citations: 1     Fields:    Translation:HumansCells
    3. Kuburich NA, Sabapathy T, Demestichas BR, Maddela JJ, den Hollander P, Mani SA. Proactive and reactive roles of TGF-? in cancer. Semin Cancer Biol. 2023 10; 95:120-139. PMID: 37572731; PMCID: PMC10530624.
      Citations: 1     Fields:    Translation:HumansCells
    4. Fathi M, Martinez-Paniagua M, Rezvan A, Montalvo MJ, Mohanty V, Chen K, Mani SA, Varadarajan N. Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling. iScience. 2023 Apr 21; 26(4):106482. PMID: 37091228; PMCID: PMC10119611.
      Citations: 4     
    5. Friedlaender A, Addeo A, Miranda-Morales E, den Hollander P, O Sintim H, Wu J, Mani SA, Subbiah V. RET aberrant cancers and RET inhibitor therapies: Current state-of-the-art and future perspectives. Pharmacol Ther. 2023 02; 242:108344. PMID: 36632846; PMCID: PMC10141525.
      Citations: 3     Fields:    Translation:Humans
    6. Castaneda M, den Hollander P, Kuburich NA, Rosen JM, Mani SA. Mechanisms of cancer metastasis. Semin Cancer Biol. 2022 Dec; 87:17-31. PMID: 36354098.
      Citations: 8     Fields:    Translation:Humans
    7. Aouad P, Zhang Y, De Martino F, Stibolt C, Ali S, Ambrosini G, Mani SA, Maggs K, Quinn HM, Sflomos G, Brisken C. Epithelial-mesenchymal plasticity determines estrogen receptor positive breast cancer dormancy and epithelial reconversion drives recurrence. Nat Commun. 2022 08 25; 13(1):4975. PMID: 36008376; PMCID: PMC9411634.
    8. Mart?nez-Pe?a F, Pearson AD, Tang EL, Kuburich NA, Mani SA, Schultz PG, Bollong MJ, Lairson LL. Synthesis and biological evaluation of novel FiVe1 derivatives as potent and selective agents for the treatment of mesenchymal cancers. Eur J Med Chem. 2022 Nov 15; 242:114638. PMID: 36001933; PMCID: PMC10377566.
    9. Castaneda M, Hollander PD, Mani SA. Forkhead Box Transcription Factors: Double-Edged Swords in Cancer. Cancer Res. 2022 06 06; 82(11):2057-2065. PMID: 35315926; PMCID: PMC9258984.
      Citations:    Fields:    Translation:Humans
    10. Kudaravalli S, den Hollander P, Mani SA. Role of p38 MAP kinase in cancer stem cells and metastasis. Oncogene. 2022 06; 41(23):3177-3185. PMID: 35501462; PMCID: PMC9166676.
      Citations: 1     Fields:    Translation:HumansCells
    11. Visal TH, den Hollander P, Cristofanilli M, Mani SA. Circulating tumour cells in the -omics era: how far are we from achieving the 'singularity'? Br J Cancer. 2022 07; 127(2):173-184. PMID: 35273384; PMCID: PMC9296521.
      Citations: 2     Fields:    Translation:HumansCells
    12. Wu L, Amjad S, Yun H, Mani S, de Perrot M. A panel of emerging EMT genes identified in malignant mesothelioma. Sci Rep. 2022 01 19; 12(1):1007. PMID: 35046456; PMCID: PMC8770645.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Deshmukh AP, den Hollander P, Kuburich NA, Vasaikar S, Joseph R, Mani SA. Enrichment of Cancer Stem Cells in a Tumorsphere Assay. Methods Mol Biol. 2022; 2429:501-507. PMID: 35507184.
      Citations:    Fields:    Translation:HumansCells
    14. Kuburich NA, den Hollander P, Deshmukh AP, Vasaikar S, Joseph R, Wicha MS, Mani SA. In Vitro Quantification of Cancer Stem Cells Using a Mammosphere Formation Assay. Methods Mol Biol. 2022; 2429:509-513. PMID: 35507185.
      Citations:    Fields:    Translation:HumansCells
    15. den Hollander P, Joseph R, Vasaikar S, Kuburich NA, Deshmukh AP, Mani SA. Limiting Dilution Tumor Initiation Assay: An In Vivo Approach for the Study of Cancer Stem Cells. Methods Mol Biol. 2022; 2429:547-554. PMID: 35507188.
      Citations:    Fields:    Translation:HumansCells
    16. Kuburich NA, den Hollander P, Pietz JT, Mani SA. Vimentin and cytokeratin: Good alone, bad together. Semin Cancer Biol. 2022 11; 86(Pt 3):816-826. PMID: 34953942; PMCID: PMC9213573.
      Citations:    Fields:    
    17. Yang J, Antin P, Berx G, Bronner M, Campbell K, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Mayor R, McClay D, Mostov KE, Newgreen DF, Runyan R, Savagner P, Stanger B, Takahashi Y, Takeichi M, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA), Blanpain C, Brabletz T, Cano A, Garc?a de Herreros A, Massagu? J, Nieto MA, Puisieux A, Stemmler MP, Theveneau E. Author Correction: Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2021 Dec; 22(12):834. PMID: 34654908; PMCID: PMC8604719.
      Citations: 2     Fields:    
    18. Balcik-Ercin P, Cayrefourcq L, Soundararajan R, Mani SA, Alix-Panabi?res C. Epithelial-to-Mesenchymal Plasticity in Circulating Tumor Cell Lines Sequentially Derived from a Patient with Colorectal Cancer. Cancers (Basel). 2021 Oct 28; 13(21). PMID: 34771571; PMCID: PMC8582537.
      Citations: 1     
    19. Ammassam Veettil R, Marcano DC, Yuan X, Zaheer M, Adumbumkulath A, Lee R, Isenhart LC, Soriano N, Mhatre K, Joseph R, Mani SA, Shin CS, Acharya G. Dextran Sulfate Polymer Wafer Promotes Corneal Wound Healing. Pharmaceutics. 2021 Oct 06; 13(10). PMID: 34683921; PMCID: PMC8539456.
    20. Fathi M, Joseph R, Adolacion JRT, Martinez-Paniagua M, An X, Gabrusiewicz K, Mani SA, Varadarajan N. Single-Cell Cloning of Breast Cancer Cells Secreting Specific Subsets of Extracellular Vesicles. Cancers (Basel). 2021 Aug 31; 13(17). PMID: 34503207; PMCID: PMC8430892.
      Citations: 1     
    21. Satpathy S, Krug K, Jean Beltran PM, Savage SR, Petralia F, Kumar-Sinha C, Dou Y, Reva B, Kane MH, Avanessian SC, Vasaikar SV, Krek A, Lei JT, Jaehnig EJ, Omelchenko T, Geffen Y, Bergstrom EJ, Stathias V, Christianson KE, Heiman DI, Cieslik MP, Cao S, Song X, Ji J, Liu W, Li K, Wen B, Li Y, Selvan ME, Soundararajan R, Visal TH, Raso MG, Parra ER, Vats P, Anand S, Schraink T, Cornwell M, Rodrigues FM, Zhu H, Mo CK, Zhang Y, da Veiga Leprevost F, Huang C, Chinnaiyan AM, Wyczalkowski MA, Omenn GS, Newton CJ, Schurer S, Ruggles KV, Jewell SD, Thiagarajan M, Mesri M, Rodriguez H, Mani SA, Udeshi ND, Getz G, Suh J, Li QK, Hostetter G, Paik PK, Dhanasekaran SM, Govindan R, Ding L, Robles AI, Clauser KR, Nesvizhskii AI, Wang P, Carr SA, Zhang B, Mani DR, Gillette MA, Clinical Proteomic Tumor Analysis Consortium, G?m?s ZH, Babur ?, Feny? D. A proteogenomic portrait of lung squamous cell carcinoma. Cell. 2021 08 05; 184(16):4348-4371.e40. PMID: 34358469; PMCID: PMC8475722.
      Citations: 9     Fields:    Translation:HumansCells
    22. Zhao N, Powell RT, Yuan X, Bae G, Roarty KP, Stossi F, Strempfl M, Toneff MJ, Johnson HL, Mani SA, Jones P, Stephan CC, Rosen JM. Morphological screening of mesenchymal mammary tumor organoids to identify drugs that reverse epithelial-mesenchymal transition. Nat Commun. 2021 07 12; 12(1):4262. PMID: 34253738; PMCID: PMC8275587.
      Citations: 4     Fields:    Translation:Animals
    23. Bushnell GG, Deshmukh AP, den Hollander P, Luo M, Soundararajan R, Jia D, Levine H, Mani SA, Wicha MS. Breast cancer dormancy: need for clinically relevant models to address current gaps in knowledge. NPJ Breast Cancer. 2021 May 28; 7(1):66. PMID: 34050189; PMCID: PMC8163741.
      Citations: 6     
    24. Deshmukh AP, Vasaikar SV, Tomczak K, Tripathi S, den Hollander P, Arslan E, Chakraborty P, Soundararajan R, Jolly MK, Rai K, Levine H, Mani SA. Identification of EMT signaling cross-talk and gene regulatory networks by single-cell RNA sequencing. Proc Natl Acad Sci U S A. 2021 05 11; 118(19). PMID: 33941680; PMCID: PMC8126782.
      Citations: 23     Fields:    Translation:HumansCells
    25. Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. CD8+ T cells inhibit metastasis and CXCL4 regulates its function. Br J Cancer. 2021 07; 125(2):176-189. PMID: 33795809; PMCID: PMC8292398.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    26. Tarallo S, Pardini B, Fox AH, Ingram H, Taccioli C, Taube JH, Mani SA. The Non-Coding RNA Journal Club: Highlights on Recent Papers-8. Noncoding RNA. 2021 Mar 19; 7(1). PMID: 33808546; PMCID: PMC8006035.
    27. Tripathi SC, Jolly MK, Mani SA, Levine H. Editorial: Characterizing the Multi-Faceted Dynamics of Tumor Cell Plasticity. Front Mol Biosci. 2020; 7:630276. PMID: 33553244; PMCID: PMC7855584.
    28. Vasaikar SV, Deshmukh AP, den Hollander P, Addanki S, Kuburich NA, Kudaravalli S, Joseph R, Chang JT, Soundararajan R, Mani SA. EMTome: a resource for pan-cancer analysis of epithelial-mesenchymal transition genes and signatures. Br J Cancer. 2021 01; 124(1):259-269. PMID: 33299129; PMCID: PMC7782839.
      Citations: 27     Fields:    Translation:HumansCells
    29. Yang J, Antin P, Berx G, Bronner M, Campbell K, Casanova J, Christofori G, Dedhar S, Derynck R, Ford HL, Fuxe J, Goodall GJ, Hadjantonakis AK, Huang RYJ, Kalcheim C, Kalluri R, Kang Y, Khew-Goodall Y, Levine H, Liu J, Longmore GD, Mani SA, Mayor R, McClay D, Mostov KE, Newgreen DF, Runyan R, Savagner P, Stanger B, Takahashi Y, Takeichi M, Thiery JP, Thompson EW, Weinberg RA, Williams ED, Xing J, Zhou BP, Sheng G, EMT International Association (TEMTIA), Blanpain C, Brabletz T, Cano A, Garc?a de Herreros A, Massagu? J, Nieto MA, Puisieux A, Stemmler MP, Theveneau E. Guidelines and definitions for research on epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2020 06; 21(6):341-352. PMID: 32300252; PMCID: PMC7250738.
      Citations: 368     Fields:    Translation:HumansAnimals
    30. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, Martin RS, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. Correction: UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 Apr; 39(15):3226-3228. PMID: 32214199; PMCID: PMC10473373.
      Citations: 2     Fields:    
    31. Arnold J, Shivakumar V, Joseph R, Vidhya Vijay G, den Hollander P, Bhangre N, Allegakoen P, Prasad R, Conley Z, Chang JT, Vasaikar S, Soundararajan R, Sreekumar A, Mani SA, Ramirez-Pe?a E, Mat?s JM, M?rquez J. The Epithelial to Mesenchymal Transition Promotes Glutamine Independence by Suppressing GLS2 Expression. Cancers (Basel). 2019 Oct 22; 11(10). PMID: 31652551; PMCID: PMC6826439.
      Citations: 15     
    32. Jia W, Deshmukh A, Mani SA, Jolly MK, Levine H. A possible role for epigenetic feedback regulation in the dynamics of the epithelial-mesenchymal transition (EMT). Phys Biol. 2019 09 06; 16(6):066004. PMID: 31342918; PMCID: PMC7085921.
      Citations: 33     Fields:    Translation:Humans
    33. Arnold JM, Gu F, Ambati CR, Rasaily U, Ramirez-Pena E, Joseph R, Manikkam M, San Martin R, Charles C, Pan Y, Chatterjee SS, Den Hollander P, Zhang W, Nagi C, Sikora AG, Rowley D, Putluri N, Zhang XH, Karanam B, Mani SA, Sreekumar A. UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression. Oncogene. 2020 04; 39(15):3089-3101. PMID: 31308490; PMCID: PMC6960374.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    34. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625; PMCID: PMC6562947.
      Citations: 42     
    35. Vijay GV, Zhao N, Den Hollander P, Toneff MJ, Joseph R, Taube JH, Sarkar TR, Ramirez-Pena E, Werden SJ, Shariati M, Gao R, Sobieski M, Stephan CC, Sphyris N, Miura N, Davies P, Chang JT, Soundararajan R, Rosen JM, Mani SA, Pietila M. GSK3? regulates epithelial-mesenchymal transition and cancer stem cell properties in triple-negative breast cancer. Breast Cancer Res. 2019 03 07; 21(1):37. PMID: 30845991; PMCID: PMC6407242.
      Citations: 34     Fields:    Translation:HumansCells
    36. Korkut A, Zaidi S, Kanchi RS, Rao S, Gough NR, Schultz A, Li X, Lorenzi PL, Berger AC, Robertson G, Kwong LN, Datto M, Roszik J, Ling S, Ravikumar V, Manyam G, Rao A, Shelley S, Liu Y, Ju Z, Hansel D, de Velasco G, Pennathur A, Andersen JB, O'Rourke CJ, Ohshiro K, Jogunoori W, Nguyen BN, Li S, Osmanbeyoglu HU, Ajani JA, Mani SA, Houseman A, Wiznerowicz M, Chen J, Gu S, Ma W, Zhang J, Tong P, Cherniack AD, Deng C, Resar L, Cancer Genome Atlas Research Network, Weinstein JN, Mishra L, Akbani R. A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-? Superfamily. Cell Syst. 2018 10 24; 7(4):422-437.e7. PMID: 30268436; PMCID: PMC6370347.
      Citations: 63     Fields:    Translation:HumansCells
    37. Xiao H, Shiu PKT, Shu J, Santulli G, Gheybi MK, Conn SJ, Taube JH, Mani SA, Song L, Calin GA, Zhang S, Bogard B, Hub? F. The Non-Coding RNA Journal Club: Highlights on Recent Papers-6. Noncoding RNA. 2018 Sep 18; 4(3). PMID: 30231579; PMCID: PMC6162737.
    38. Jolly MK, Mani SA, Levine H. Hybrid epithelial/mesenchymal phenotype(s): The 'fittest' for metastasis? Biochim Biophys Acta Rev Cancer. 2018 12; 1870(2):151-157. PMID: 29997040.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    39. Soundararajan R, Paranjape AN, Maity S, Aparicio A, Mani SA. EMT, stemness and tumor plasticity in aggressive variant neuroendocrine prostate cancers. Biochim Biophys Acta Rev Cancer. 2018 12; 1870(2):229-238. PMID: 29981816; PMCID: PMC6496942.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    40. Soundararajan R, Aparicio AM, Logothetis CJ, Mani SA, Maity SN. Function of Tumor Suppressors in Resistance to Antiandrogen Therapy and Luminal Epithelial Plasticity of Aggressive Variant Neuroendocrine Prostate Cancers. Front Oncol. 2018; 8:69. PMID: 29600194; PMCID: PMC5862804.
      Citations: 6     
    41. Jia D, Jolly MK, Tripathi SC, Den Hollander P, Huang B, Lu M, Celiktas M, Ben-Jacob E, Hanash SM, Mani SA, Levine H, Ramirez-Pe?a E, Onuchic JN. Distinguishing mechanisms underlying EMT tristability. Cancer Converg. 2017; 1(1):2. PMID: 29623961; PMCID: PMC5876698.
      Citations: 35     
    42. Bollong MJ, Pearson AD, Sarkar TR, Ahmad I, Soundararajan R, Lyssiotis CA, Mani SA, Schultz PG, Lairson LL, Pietil? M. A vimentin binding small molecule leads to mitotic disruption in mesenchymal cancers. Proc Natl Acad Sci U S A. 2017 11 14; 114(46):E9903-E9912. PMID: 29087350; PMCID: PMC5699095.
      Citations: 28     Fields:    Translation:HumansCells
    43. Taube JH, Sphyris N, Johnson KS, Reisenauer KN, Nesbit TA, Joseph R, Vijay GV, Sarkar TR, Bhangre NA, Song JJ, Chang JT, Lee MG, Soundararajan R, Mani SA. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017 Sep 12; 8(39):65548-65565. PMID: 29029452; PMCID: PMC5630352.
      Citations: 24     Fields:    
    44. Mani SA, Santulli G, Taube JH, Achour C, Bogard B, Hub? F. The Non-Coding RNA Journal Club: Highlights on Recent Papers-5. Noncoding RNA. 2017 Jun 14; 3(2). PMID: 29657292; PMCID: PMC5831933.
      Citations: 1     
    45. Tian L, Zhang XHF, Mani SA. Effective models for antimetastatic therapies. Oncotarget. 2017 Nov 07; 8(55):93295-93296. PMID: 29212140; PMCID: PMC5706786.
      Citations:    Fields:    
    46. Yam C, Mani SA, Moulder SL. Targeting the Molecular Subtypes of Triple Negative Breast Cancer: Understanding the Diversity to Progress the Field. Oncologist. 2017 09; 22(9):1086-1093. PMID: 28559413; PMCID: PMC5599192.
      Citations: 34     Fields:    Translation:Humans
    47. Rigoutsos I, Lee SK, Nam SY, Anfossi S, Pasculli B, Pichler M, Jing Y, Rodriguez-Aguayo C, Telonis AG, Rossi S, Ivan C, Catela Ivkovic T, Fabris L, Clark PM, Ling H, Shimizu M, Redis RS, Shah MY, Zhang X, Okugawa Y, Jung EJ, Tsirigos A, Huang L, Ferdin J, Spizzo R, Nicoloso MS, Paranjape AN, Shariati M, Tiron A, Yeh JJ, Teruel-Montoya R, Xiao L, Menter D, Jiang ZQ, Flores ER, Negrini M, Goel A, Bar-Eli M, Mani SA, Liu CG, Lopez-Berestein G, Berindan-Neagoe I, Esteller M, Kopetz S, Lanza G, Calin GA, Gaf? R, Melo SA. N-BLR, a primate-specific non-coding transcript leads to colorectal cancer invasion and migration. Genome Biol. 2017 05 24; 18(1):98. PMID: 28535802; PMCID: PMC5442648.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    48. Tian L, Goldstein A, Wang H, Ching Lo H, Sun Kim I, Welte T, Sheng K, Dobrolecki LE, Zhang X, Putluri N, Phung TL, Mani SA, Stossi F, Sreekumar A, Mancini MA, Decker WK, Zong C, Lewis MT, Zhang XH. Mutual regulation of tumour vessel normalization and immunostimulatory reprogramming. Nature. 2017 04 13; 544(7649):250-254. PMID: 28371798; PMCID: PMC5788037.
      Citations: 237     Fields:    Translation:HumansAnimalsCells
    49. Gautheret D, Taube JH, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK, Zhang B, Wang Y, Salzman DW, Weidhaas JB. Erratum: The Non-Coding RNA Journal Club: Highlights on Recent Papers-4. Non-Coding RNA 2016, 2, 9. Noncoding RNA. 2016 09 30; 2(4). PMID: 29657269; PMCID: PMC5831929.
      Citations: 1     
    50. Gautheret D, Taube JH, Mani SA, Santulli G, Cuerda-Gil D, Slotkin RK, Zhang B, Wang Y, Salzman DW, Weidhaas JB. The Non-Coding RNA Journal Club: Highlights on Recent Papers-4. Noncoding RNA. 2016 Sep 21; 2(3). PMID: 29657267; PMCID: PMC5831907.
    51. Chakravarty D, Tiwary CS, Woellner CF, Radhakrishnan S, Vinod S, Ozden S, da Silva Autreto PA, Bhowmick S, Asif S, Mani SA, Galvao DS, Ajayan PM. 3D Porous Graphene by Low-Temperature Plasma Welding for Bone Implants. Adv Mater. 2016 Oct; 28(40):8959-8967. PMID: 27562359.
      Citations: 5     Fields:    
    52. Svanidze E, Besara T, Ozaydin MF, Tiwary CS, Wang JK, Radhakrishnan S, Mani S, Xin Y, Han K, Liang H, Siegrist T, Ajayan PM, Morosan E. High hardness in the biocompatible intermetallic compound ?-Ti3Au. Sci Adv. 2016 07; 2(7):e1600319. PMID: 27453942; PMCID: PMC4956191.
      Citations: 6     Fields:    
    53. Mitra S, Federico L, Zhao W, Dennison J, Sarkar TR, Zhang F, Takiar V, Cheng KW, Mani S, Lee JS, Mills GB. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 2016 Jun 28; 7(26):40252-40265. PMID: 27259233; PMCID: PMC5130006.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    54. Kwon OJ, Zhang L, Wang J, Su Q, Feng Q, Zhang XH, Mani SA, Paulter R, Creighton CJ, Ittmann MM, Xin L. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. J Clin Invest. 2016 07 01; 126(7):2626-41. PMID: 27294523; PMCID: PMC4922719.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Ashokkumar M, Cristian Chipara A, Tharangattu Narayanan N, Anumary A, Sruthi R, Thanikaivelan P, Vajtai R, Mani SA, Ajayan PM. Three-Dimensional Porous Sponges from Collagen Biowastes. ACS Appl Mater Interfaces. 2016 Jun 15; 8(23):14836-44. PMID: 27219483.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    56. Jolly MK, Tripathi SC, Jia D, Mooney SM, Celiktas M, Hanash SM, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. Stability of the hybrid epithelial/mesenchymal phenotype. Oncotarget. 2016 May 10; 7(19):27067-84. PMID: 27008704; PMCID: PMC5053633.
      Citations: 173     Fields:    Translation:HumansCells
    57. Boareto M, Jolly MK, Goldman A, Mani SA, Sengupta S, Ben-Jacob E, Levine H, Onuchic JN, Pietil? M. Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. J R Soc Interface. 2016 05; 13(118). PMID: 27170649; PMCID: PMC4892257.
      Citations: 52     Fields:    Translation:HumansCells
    58. Vijay GV, Soundararajan R, Yu X, Symmans WF, Sphyris N, Mani SA, Pietil? M. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Sci Rep. 2016 Apr 11; 6:23070. PMID: 27064522; PMCID: PMC4827390.
      Citations: 10     Fields:    Translation:HumansCells
    59. Dhawan A, Madani Tonekaboni SA, Taube JH, Hu S, Sphyris N, Mani SA, Kohandel M. Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia. Sci Rep. 2016 Feb 03; 6:18074. PMID: 26838463; PMCID: PMC4738268.
      Citations: 13     Fields:    Translation:HumansCells
    60. Zhao W, Prijic S, Urban BC, Tisza MJ, Zuo Y, Li L, Tan Z, Chen X, Mani SA, Chang JT. Candidate Antimetastasis Drugs Suppress the Metastatic Capacity of Breast Cancer Cells by Reducing Membrane Fluidity. Cancer Res. 2016 04 01; 76(7):2037-49. PMID: 26825169; PMCID: PMC8491548.
      Citations: 50     Fields:    Translation:HumansCells
    61. Bhowmik SK, Arnold JM, Putluri V, Sphyris N, Michailidis G, Putluri N, Ambs S, Sreekumar A, Mani SA, Ramirez-Pe?a E. EMT-induced metabolite signature identifies poor clinical outcome. Oncotarget. 2015 Dec 15; 6(40):42651-60. PMID: 26315396; PMCID: PMC4767460.
      Citations: 24     Fields:    Translation:HumansCells
    62. Jolly MK, Jia D, Boareto M, Mani SA, Pienta KJ, Ben-Jacob E, Levine H. Coupling the modules of EMT and stemness: A tunable 'stemness window' model. Oncotarget. 2015 Sep 22; 6(28):25161-74. PMID: 26317796; PMCID: PMC4694822.
      Citations: 86     Fields:    Translation:HumansCells
    63. Cohen EN, Gao H, Anfossi S, Mego M, Reddy NG, Debeb B, Giordano A, Tin S, Wu Q, Garza RJ, Cristofanilli M, Mani SA, Croix DA, Ueno NT, Woodward WA, Luthra R, Krishnamurthy S, Reuben JM. Inflammation Mediated Metastasis: Immune Induced Epithelial-To-Mesenchymal Transition in Inflammatory Breast Cancer Cells. PLoS One. 2015; 10(7):e0132710. PMID: 26207636; PMCID: PMC4514595.
      Citations: 52     Fields:    Translation:HumansCells
    64. Soundararajan R, Paranjape AN, Barsan V, Chang JT, Mani SA. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Sci Rep. 2015 Jun 30; 5:11766. PMID: 26123483; PMCID: PMC4485318.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    65. Sphyris N, Sarkar TR, Battula VL, Andreeff M, Mani SA. GD2 and GD3 synthase: novel drug targets for cancer therapy. Mol Cell Oncol. 2015 Jul-Sep; 2(3):e975068. PMID: 27308452; PMCID: PMC4905286.
      Citations: 2     
    66. Mallampati S, Leng X, Ma H, Zeng J, Li J, Wang H, Lin K, Lu Y, Yang Y, Sun B, Gong Y, Lee JS, Konopleva M, Andreeff M, Arlinghaus RB, Cai Z, Fang B, Shen H, Han X, Hirsch-Ginsberg CF, Gao X, Paranjape AN, Mani SA, Clise-Dwyer K, Sun X. Tyrosine kinase inhibitors induce mesenchymal stem cell-mediated resistance in BCR-ABL+ acute lymphoblastic leukemia. Blood. 2015 May 07; 125(19):2968-73. PMID: 25712988; PMCID: PMC4424418.
      Citations: 13     Fields:    Translation:AnimalsCells
    67. Jolly MK, Huang B, Lu M, Mani SA, Levine H, Ben-Jacob E. Towards elucidating the connection between epithelial-mesenchymal transitions and stemness. J R Soc Interface. 2014 Dec 06; 11(101):20140962. PMID: 25339690; PMCID: PMC4223923.
      Citations: 79     Fields:    Translation:HumansCells
    68. Krohn A, Ahrens T, Yalcin A, Wehrle J, Taromi S, Wollner S, Follo M, Brabletz T, Mani SA, Claus R, Burger M, Pl?nes T, Hackanson B. Tumor cell heterogeneity in Small Cell Lung Cancer (SCLC): phenotypical and functional differences associated with Epithelial-Mesenchymal Transition (EMT) and DNA methylation changes. PLoS One. 2014; 9(6):e100249. PMID: 24959847; PMCID: PMC4069054.
      Citations: 27     Fields:    Translation:HumansCells
    69. Malouf GG, Taube JH, Lu Y, Roysarkar T, Panjarian S, Estecio MR, Jelinek J, Yamazaki J, Raynal NJ, Long H, Tahara T, Tinnirello A, Ramachandran P, Zhang XY, Liang S, Mani SA, Issa JP. Architecture of epigenetic reprogramming following Twist1-mediated epithelial-mesenchymal transition. Genome Biol. 2013 Dec 24; 14(12):R144. PMID: 24367927; PMCID: PMC4053791.
      Citations: 38     Fields:    Translation:HumansCells
    70. Liu Y, Zhou R, Baumbusch LO, Tsavachidis S, Brewster AM, Do KA, Sahin A, Hortobagyi GN, Taube JH, Mani SA, Mills GB, Thompson PA, Bondy ML, Aar?e J, W?rnberg F, B?rresen-Dale AL. Genomic copy number imbalances associated with bone and non-bone metastasis of early-stage breast cancer. Breast Cancer Res Treat. 2014 Jan; 143(1):189-201. PMID: 24305980; PMCID: PMC3993091.
      Citations: 5     Fields:    Translation:Humans
    71. Romero-Aburto R, Narayanan TN, Nagaoka Y, Hasumura T, Mitcham TM, Fukuda T, Cox PJ, Bouchard RR, Maekawa T, Kumar DS, Torti SV, Mani SA, Ajayan PM. Fluorinated graphene oxide; a new multimodal material for biological applications. Adv Mater. 2013 Oct 18; 25(39):5632-7. PMID: 24038195; PMCID: PMC3938113.
      Citations: 28     Fields:    Translation:HumansCells
    72. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA, Gaf? R, Le Marchand L. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep; 23(9):1446-61. PMID: 23796952; PMCID: PMC3759721.
      Citations: 314     Fields:    Translation:HumansAnimalsCells
    73. Zarkoob H, Taube JH, Singh SK, Mani SA, Kohandel M. Investigating the link between molecular subtypes of glioblastoma, epithelial-mesenchymal transition, and CD133 cell surface protein. PLoS One. 2013; 8(5):e64169. PMID: 23734191; PMCID: PMC3667082.
      Citations: 41     Fields:    Translation:HumansCells
    74. Chang JT, Mani SA. Sheep, wolf, or werewolf: cancer stem cells and the epithelial-to-mesenchymal transition. Cancer Lett. 2013 Nov 28; 341(1):16-23. PMID: 23499890; PMCID: PMC3762892.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    75. Hollier BG, Tinnirello AA, Werden SJ, Evans KW, Taube JH, Sarkar TR, Sphyris N, Shariati M, Kumar SV, Battula VL, Herschkowitz JI, Guerra R, Chang JT, Miura N, Rosen JM, Mani SA. FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer. Cancer Res. 2013 Mar 15; 73(6):1981-92. PMID: 23378344; PMCID: PMC3602160.
      Citations: 132     Fields:    Translation:HumansAnimalsCells
    76. Lu J, Ye X, Fan F, Xia L, Bhattacharya R, Bellister S, Tozzi F, Sceusi E, Zhou Y, Tachibana I, Maru DM, Hawke DH, Rak J, Mani SA, Zweidler-McKay P, Ellis LM. Endothelial cells promote the colorectal cancer stem cell phenotype through a soluble form of Jagged-1. Cancer Cell. 2013 Feb 11; 23(2):171-85. PMID: 23375636; PMCID: PMC3574187.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    77. Yao Y, Suraokar M, Darnay BG, Hollier BG, Shaiken TE, Asano T, Chen CH, Chang BH, Lu Y, Mills GB, Sarbassov D, Mani SA, Abbruzzese JL, Reddy SA. BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. Sci Signal. 2013 Jan 08; 6(257):ra2. PMID: 23300339; PMCID: PMC3748614.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    78. Taube JH, Malouf GG, Lu E, Sphyris N, Vijay V, Ramachandran PP, Ueno KR, Gaur S, Nicoloso MS, Rossi S, Herschkowitz JI, Rosen JM, Issa JP, Calin GA, Chang JT, Mani SA. Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties. Sci Rep. 2013; 3:2687. PMID: 24045437; PMCID: PMC3776231.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    79. Giordano A, Gao H, Anfossi S, Cohen E, Mego M, Lee BN, Tin S, De Laurentiis M, Parker CA, Alvarez RH, Valero V, Ueno NT, De Placido S, Mani SA, Esteva FJ, Cristofanilli M, Reuben JM. Epithelial-mesenchymal transition and stem cell markers in patients with HER2-positive metastatic breast cancer. Mol Cancer Ther. 2012 Nov; 11(11):2526-34. PMID: 22973057; PMCID: PMC3500676.
      Citations: 97     Fields:    Translation:HumansCells
    80. Fan F, Samuel S, Evans KW, Lu J, Xia L, Zhou Y, Sceusi E, Tozzi F, Ye XC, Mani SA, Ellis LM. Overexpression of snail induces epithelial-mesenchymal transition and a cancer stem cell-like phenotype in human colorectal cancer cells. Cancer Med. 2012 Aug; 1(1):5-16. PMID: 23342249; PMCID: PMC3544430.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    81. Battula VL, Shi Y, Evans KW, Wang RY, Spaeth EL, Jacamo RO, Guerra R, Sahin AA, Marini FC, Hortobagyi G, Mani SA, Andreeff M. Ganglioside GD2 identifies breast cancer stem cells and promotes tumorigenesis. J Clin Invest. 2012 Jun; 122(6):2066-78. PMID: 22585577; PMCID: PMC3591166.
      Citations: 120     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    82. Narayanan TN, Gupta BK, Vithayathil SA, Aburto RR, Mani SA, Taha-Tijerina J, Xie B, Kaipparettu BA, Torti SV, Ajayan PM. Hybrid 2D nanomaterials as dual-mode contrast agents in cellular imaging. Adv Mater. 2012 Jun 12; 24(22):2992-8. PMID: 22573478; PMCID: PMC3395317.
      Citations: 11     Fields:    Translation:HumansCells
    83. Pirone JR, Rein J, Carey LA, Lubet RA, Mani SA, Amos KD, Troester MA, Rom?n-P?rez E, Casbas-Hern?ndez P. Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Res. 2012 Mar 19; 14(2):R51. PMID: 22429463; PMCID: PMC3446385.
      Citations: 47     Fields:    Translation:HumansCells
    84. Guo W, Keckesova Z, Donaher JL, Shibue T, Tischler V, Reinhardt F, Itzkovitz S, Noske A, Bell G, Tam WL, Mani SA, van Oudenaarden A, Weinberg RA, Z?rrer-H?rdi U. Slug and Sox9 cooperatively determine the mammary stem cell state. Cell. 2012 Mar 02; 148(5):1015-28. PMID: 22385965; PMCID: PMC3305806.
      Citations: 497     Fields:    Translation:HumansAnimalsCells
    85. Kolonin MG, Evans KW, Mani SA, Gomer RH. Alternative origins of stroma in normal organs and disease. Stem Cell Res. 2012 Mar; 8(2):312-23. PMID: 22209011; PMCID: PMC3571702.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    86. Sphyris N, Mani SA. pIgR: frenemy of inflammation, EMT, and HCC progression. J Natl Cancer Inst. 2011 Nov 16; 103(22):1644-5. PMID: 22025623; PMCID: PMC3216969.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    87. Walia V, Yu Y, Cao D, Sun M, McLean JR, Hollier BG, Cheng J, Mani SA, Rao K, Premkumar L, Elble RC. Loss of breast epithelial marker hCLCA2 promotes epithelial-to-mesenchymal transition and indicates higher risk of metastasis. Oncogene. 2012 Apr 26; 31(17):2237-46. PMID: 21909135; PMCID: PMC4154589.
      Citations: 42     Fields:    Translation:HumansCells
    88. Mani SA, Barton MC. HDAC3 at the fulcrum of an epithelial-mesenchymal balance. Mol Cell. 2011 Sep 02; 43(5):697-8. PMID: 21884971; PMCID: PMC3528183.
      Citations: 2     Fields:    
    89. Mego M, Mani SA, Lee BN, Li C, Evans KW, Cohen EN, Gao H, Jackson SA, Giordano A, Hortobagyi GN, Cristofanilli M, Lucci A, Reuben JM. Expression of epithelial-mesenchymal transition-inducing transcription factors in primary breast cancer: The effect of neoadjuvant therapy. Int J Cancer. 2012 Feb 15; 130(4):808-16. PMID: 21387303; PMCID: PMC3169728.
      Citations: 74     Fields:    Translation:HumansCells
    90. May CD, Sphyris N, Evans KW, Werden SJ, Guo W, Mani SA. Epithelial-mesenchymal transition and cancer stem cells: a dangerously dynamic duo in breast cancer progression. Breast Cancer Res. 2011 Feb 08; 13(1):202. PMID: 21392411; PMCID: PMC3109556.
      Citations: 170     Fields:    Translation:HumansAnimalsCells
    91. Tong Z, Chakraborty S, Sung B, Koolwal P, Kaur S, Aggarwal BB, Mani SA, Bresalier RS, Batra SK, Guha S. Epidermal growth factor down-regulates the expression of neutrophil gelatinase-associated lipocalin (NGAL) through E-cadherin in pancreatic cancer cells. Cancer. 2011 Jun 01; 117(11):2408-18. PMID: 24048788; PMCID: PMC3134548.
      Citations: 15     Fields:    Translation:HumansCells
    92. Mego M, Mani SA, Cristofanilli M. Molecular mechanisms of metastasis in breast cancer--clinical applications. Nat Rev Clin Oncol. 2010 Dec; 7(12):693-701. PMID: 20956980.
      Citations: 83     Fields:    Translation:HumansAnimalsCells
    93. Taube JH, Herschkowitz JI, Komurov K, Zhou AY, Gupta S, Yang J, Hartwell K, Onder TT, Gupta PB, Evans KW, Hollier BG, Ram PT, Lander ES, Rosen JM, Weinberg RA, Mani SA. Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes. Proc Natl Acad Sci U S A. 2010 Aug 31; 107(35):15449-54. PMID: 20713713; PMCID: PMC2932589.
      Citations: 535     Fields:    Translation:HumansCells
    94. Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, Wang RY, Brisken C, Guerra R, Andreeff M, Mani SA. Epithelial-mesenchymal transition-derived cells exhibit multilineage differentiation potential similar to mesenchymal stem cells. Stem Cells. 2010 Aug; 28(8):1435-45. PMID: 20572012; PMCID: PMC3523728.
      Citations: 123     Fields:    Translation:HumansCells
    95. Blick T, Hugo H, Widodo E, Waltham M, Pinto C, Mani SA, Weinberg RA, Neve RM, Lenburg ME, Thompson EW. Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer. J Mammary Gland Biol Neoplasia. 2010 Jun; 15(2):235-52. PMID: 20521089.
      Citations: 156     Fields:    Translation:HumansCells
    96. Lu J, Steeg PS, Price JE, Krishnamurthy S, Mani SA, Reuben J, Cristofanilli M, Dontu G, Bidaut L, Valero V, Hortobagyi GN, Yu D. Breast cancer metastasis: challenges and opportunities. Cancer Res. 2009 Jun 15; 69(12):4951-3. PMID: 19470768.
      Citations: 98     Fields:    Translation:HumansAnimals
    97. Hollier BG, Evans K, Mani SA. The epithelial-to-mesenchymal transition and cancer stem cells: a coalition against cancer therapies. J Mammary Gland Biol Neoplasia. 2009 Mar; 14(1):29-43. PMID: 19242781.
      Citations: 168     Fields:    Translation:HumansAnimalsCells
    98. Bloushtain-Qimron N, Yao J, Snyder EL, Shipitsin M, Campbell LL, Mani SA, Hu M, Chen H, Ustyansky V, Antosiewicz JE, Argani P, Halushka MK, Thomson JA, Pharoah P, Porgador A, Sukumar S, Parsons R, Richardson AL, Stampfer MR, Gelman RS, Nikolskaya T, Nikolsky Y, Polyak K. Cell type-specific DNA methylation patterns in the human breast. Proc Natl Acad Sci U S A. 2008 Sep 16; 105(37):14076-81. PMID: 18780791; PMCID: PMC2532972.
      Citations: 115     Fields:    Translation:HumansCells
    99. Mani SA, Guo W, Liao MJ, Eaton EN, Ayyanan A, Zhou AY, Brooks M, Reinhard F, Zhang CC, Shipitsin M, Campbell LL, Polyak K, Brisken C, Yang J, Weinberg RA. The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell. 2008 May 16; 133(4):704-15. PMID: 18485877; PMCID: PMC2728032.
      Citations: 4147     Fields:    Translation:HumansAnimalsCells
    100. Onder TT, Gupta PB, Mani SA, Yang J, Lander ES, Weinberg RA. Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways. Cancer Res. 2008 May 15; 68(10):3645-54. PMID: 18483246.
      Citations: 688     Fields:    Translation:HumansAnimalsCells
    101. Liao MJ, Zhang CC, Zhou B, Zimonjic DB, Mani SA, Kaba M, Gifford A, Reinhardt F, Popescu NC, Guo W, Eaton EN, Lodish HF, Weinberg RA. Enrichment of a population of mammary gland cells that form mammospheres and have in vivo repopulating activity. Cancer Res. 2007 Sep 01; 67(17):8131-8. PMID: 17804725.
      Citations: 85     Fields:    Translation:AnimalsCells
    102. Mani SA, Yang J, Brooks M, Schwaninger G, Zhou A, Miura N, Kutok JL, Hartwell K, Richardson AL, Weinberg RA. Mesenchyme Forkhead 1 (FOXC2) plays a key role in metastasis and is associated with aggressive basal-like breast cancers. Proc Natl Acad Sci U S A. 2007 Jun 12; 104(24):10069-74. PMID: 17537911; PMCID: PMC1891217.
      Citations: 274     Fields:    Translation:HumansAnimalsCells
    103. Yang J, Mani SA, Weinberg RA. Exploring a new twist on tumor metastasis. Cancer Res. 2006 May 01; 66(9):4549-52. PMID: 16651402.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    104. Gupta PB, Mani S, Yang J, Hartwell K, Weinberg RA. The evolving portrait of cancer metastasis. Cold Spring Harb Symp Quant Biol. 2005; 70:291-7. PMID: 16869765.
      Citations: 29     Fields:    Translation:HumansAnimals
    105. Yang J, Mani SA, Donaher JL, Ramaswamy S, Itzykson RA, Come C, Savagner P, Gitelman I, Richardson A, Weinberg RA. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell. 2004 Jun 25; 117(7):927-39. PMID: 15210113.
      Citations: 1787     Fields:    Translation:HumansAnimalsCells
    106. Samudre KR, Mani SA, Vathsala PG, Rangarajan PN, Padmanaban G. Phenobarbitone-mediated translocation of the cytosolic proteins interacting with the 5'-proximal region of rat liver CYP2B1/B2 gene into the nucleus. Biochem Biophys Res Commun. 2002 Mar 29; 292(2):312-7. PMID: 11906163.
      Citations: 1     Fields:    Translation:AnimalsCells
    107. Harish S, Khanam T, Mani S, Rangarajan P. Transcriptional activation by hepatocyte nuclear factor-4 in a cell-free system derived from rat liver nuclei. Nucleic Acids Res. 2001 Mar 01; 29(5):1047-53. PMID: 11222753; PMCID: PMC29722.
      Citations: 6     Fields:    Translation:AnimalsCells
    108. Mani SA, Harish S, Vathsala PG, Rangarajan PN, Padmanaban G. Receptor-mediated gene delivery approach demonstrates the role of 5'-proximal DNA region in conferring phenobarbitone responsiveness to CYP2B2 gene in rat liver in vivo. Biochem Biophys Res Commun. 2000 Feb 24; 268(3):734-9. PMID: 10679274.
      Citations: 2     Fields:    Translation:AnimalsCells
    109. Fernandez MA, Mani SA, Rangarajan PN, Seshagiri PB. Sperm-mediated gene transfer into oocytes of the golden hamster: assessment of sperm function. Indian J Exp Biol. 1999 Nov; 37(11):1085-92. PMID: 10783740.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    110. Prabhu L, Upadhya P, Ram N, Nirodi CS, Sultana S, Vatsala PG, Mani SA, Rangarajan PN, Surolia A, Padmanaban G. A model for the transcriptional regulation of the CYP2B1/B2 gene in rat liver. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9628-32. PMID: 7568186; PMCID: PMC40855.
      Citations: 3     Fields:    Translation:AnimalsCells
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    112. A novel embryonic plasticity gene signature that predicts metastatic competence and clinical outcome. Scientific Reports. 5.
    113. Gene expression in extratumoral microenvironment predicts clinical outcome in breast cancer patients. Breast Cancer Research. 14.
    114. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene.
    115. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 107:19132.
    116. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene.
    117. 3D Porous Graphene by Low-Temperature Plasma Welding for Bone Implants. Advanced Materials.
    118. Circulating breast tumor cells exhibit dynamic changes in epithelial and mesenchymal composition. Breast Diseases. 24:225-226.
    119. The Z-cad dual fluorescent sensor detects dynamic changes between the epithelial and mesenchymal cellular states. BMC Biology. 14.
    120. Epithelial-to-mesenchymal transition, stem cells, and cancer progression. 643-666.
    121. Whom to blame for metastasis, the epithelial-mesenchymal transition or the tumor microenvironment?. Cancer Letters.
    122. Synthesis of fluorinated graphene oxide and its amphiphobic properties. Particle and Particle Systems Characterization. 30:266-272.
    123. Three-Dimensional Porous Sponges from Collagen Biowastes. ACS Applied Materials and Interfaces. 8:14836-14844.
    124. EMT-induced metabolite signature identifies poor clinical outcome. Oncotarget. 6:42651-42660.
    125. GD3 synthase regulates epithelial-mesenchymal transition and metastasis in breast cancer. Oncogene.
    126. Stability of the hybrid epithelial/mesenchymal phenotype. Oncotarget. 7:27067-27084.
    127. Metal-Free Dual Modal Contrast Agents Based on Fluorographene Quantum Dots. Particle and Particle Systems Characterization. 34.
    128. Candidate antimetastasis drugs suppress the metastatic capacity of breast cancer cells by reducing membrane fluidity. Cancer Research. 76:2037-2049.
    129. Notch-Jagged signalling can give rise to clusters of cells exhibiting a hybrid epithelial/mesenchymal phenotype. Journal of the Royal Society Interface. 13.
    130. Rab25 acts as an oncogene in luminal B breast cancer and is causally associated with Snail driven EMT. Oncotarget. 7:40252-40265.
    131. Notch promotes tumor metastasis in a prostate-specific Pten-null mouse model. Journal of Clinical Investigation. 126:2626-2641.
    132. Fluorescent superparamagnetic iron oxide core-shell nanoprobes for multimodal cellular imaging. Materials Express. 2:265-274.
    133. Coupling the modules of EMT and stemness. Oncotarget. 6:25161-25174.
    134. FOXC2 regulates the G2/M transition of stem cell-rich breast cancer cells and sensitizes them to PLK1 inhibition. Scientific Reports. 6.
    135. Mathematical modelling of phenotypic plasticity and conversion to a stem-cell state under hypoxia. Scientific Reports. 6.
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