TitleAssociate Professor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1881 East Road
Houston TX 77054-3005
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang B, Tan Z, Bohinc K, Zhang S. Interaction between nanoparticles and charged phospholipid membranes. Phys Chem Chem Phys. 2018 Nov 28; 20(46):29249-29263. PMID: 30427341.
      Citations: 3     Fields:    
    2. Zhang S, Tan Z. Editorial: The Elephant in the Room: Targeting Ras for Therapeutic Development. Mini Rev Med Chem. 2016; 16(5):343-4. PMID: 26873479.
      Citations:    Fields:    Translation:Humans
    3. Monroig Pdel C, Chen L, Zhang S, Calin GA. Small molecule compounds targeting miRNAs for cancer therapy. Adv Drug Deliv Rev. 2015 Jan; 81:104-16. PMID: 25239236; PMCID: PMC4461213.
      Citations: 53     Fields:    Translation:HumansAnimals
    4. Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E. Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein. Cancer Res. 2014 Jun 01; 74(11):3127-36. PMID: 24755468; PMCID: PMC4047720.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    5. Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68. PMID: 23911321; PMCID: PMC3845452.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    6. De S, Chen L, Zhang S, Gilbertson SR. Synthesis of a 2(1H)-pyridone library via rhodium-catalyzed formation of isomunchones. ACS Comb Sci. 2013 Jul 08; 15(7):340-3. PMID: 23742807.
      Citations:    Fields:    Translation:Cells
    7. Wu B, Dong D, Hu M, Zhang S. Quantitative prediction of glucuronidation in humans using the in vitro- in vivo extrapolation approach. Curr Top Med Chem. 2013; 13(11):1343-52. PMID: 23675940.
      Citations: 16     Fields:    Translation:HumansCells
    8. Reddy AS, Zhang S. Polypharmacology: drug discovery for the future. Expert Rev Clin Pharmacol. 2013 Jan; 6(1):41-7. PMID: 23272792; PMCID: PMC3809828.
      Citations: 116     Fields:    Translation:Humans
    9. Phatak SS, Zhang S. A novel multi-modal drug repurposing approach for identification of potent ACK1 inhibitors. Pac Symp Biocomput. 2013; 29-40. PMID: 23424109; PMCID: PMC3864554.
      Citations: 11     Fields:    Translation:Humans
    10. Chen L, Calin GA, Zhang S. Novel insights of structure-based modeling for RNA-targeted drug discovery. J Chem Inf Model. 2012 Oct 22; 52(10):2741-53. PMID: 22947071; PMCID: PMC3869234.
      Citations: 11     Fields:    Translation:HumansCells
    11. Islas JF, Liu Y, Weng KC, Robertson MJ, Zhang S, Prejusa A, Harger J, Tikhomirova D, Chopra M, Iyer D, Mercola M, Oshima RG, Willerson JT, Potaman VN, Schwartz RJ. Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors. Proc Natl Acad Sci U S A. 2012 Aug 07; 109(32):13016-21. PMID: 22826236; PMCID: PMC3420197.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    12. Wu B, Wang X, Zhang S, Hu M. Accurate prediction of glucuronidation of structurally diverse phenolics by human UGT1A9 using combined experimental and in silico approaches. Pharm Res. 2012 Jun; 29(6):1544-61. PMID: 22302521; PMCID: PMC3409642.
      Citations: 6     Fields:    Translation:HumansCells
    13. Meng S, Wu B, Singh R, Yin T, Morrow JK, Zhang S, Hu M. SULT1A3-mediated regiospecific 7-O-sulfation of flavonoids in Caco-2 cells can be explained by the relevant molecular docking studies. Mol Pharm. 2012 Apr 02; 9(4):862-73. PMID: 22352375; PMCID: PMC3404749.
      Citations: 10     Fields:    Translation:HumansCells
    14. Ihle NT, Byers LA, Kim ES, Saintigny P, Lee JJ, Blumenschein GR, Tsao A, Liu S, Larsen JE, Wang J, Diao L, Coombes KR, Chen L, Zhang S, Abdelmelek MF, Tang X, Papadimitrakopoulou V, Minna JD, Lippman SM, Hong WK, Herbst RS, Wistuba II, Heymach JV, Powis G. Effect of KRAS oncogene substitutions on protein behavior: implications for signaling and clinical outcome. J Natl Cancer Inst. 2012 Feb 08; 104(3):228-39. PMID: 22247021; PMCID: PMC3274509.
      Citations: 199     Fields:    Translation:HumansCells
    15. Zhang S. In silico lead identification and optimization for drug discovery. Curr Pharm Des. 2012; 18(9):1171-2. PMID: 22316149.
      Citations:    Fields:    Translation:Humans
    16. Chen L, Morrow JK, Tran HT, Phatak SS, Du-Cuny L, Zhang S. From laptop to benchtop to bedside: structure-based drug design on protein targets. Curr Pharm Des. 2012; 18(9):1217-39. PMID: 22316152; PMCID: PMC3820560.
      Citations: 16     Fields:    Translation:HumansCells
    17. Morrow JK, Zhang S. Computational prediction of protein hot spot residues. Curr Pharm Des. 2012; 18(9):1255-65. PMID: 22316154; PMCID: PMC3807665.
      Citations: 38     Fields:    Translation:HumansCells
    18. Yadav VR, Prasad S, Gupta SC, Sung B, Phatak SS, Zhang S, Aggarwal BB. 3-Formylchromone interacts with cysteine 38 in p65 protein and with cysteine 179 in I?Ba kinase, leading to down-regulation of nuclear factor-?B (NF-?B)-regulated gene products and sensitization of tumor cells. J Biol Chem. 2012 Jan 02; 287(1):245-256. PMID: 22065587; PMCID: PMC3249075.
      Citations: 8     Fields:    Translation:HumansCells
    19. Wu B, Zhang S, Hu M. Evaluation of 3,3',4'-trihydroxyflavone and 3,6,4'-trihydroxyflavone (4'-O-glucuronidation) as the in vitro functional markers for hepatic UGT1A1. Mol Pharm. 2011 Dec 05; 8(6):2379-89. PMID: 21985641; PMCID: PMC3404744.
      Citations: 6     Fields:    Translation:HumansCells
    20. Du-Cuny L, Chen L, Zhang S. A critical assessment of combined ligand- and structure-based approaches to HERG channel blocker modeling. J Chem Inf Model. 2011 Nov 28; 51(11):2948-60. PMID: 21902220; PMCID: PMC3894065.
      Citations: 14     Fields:    Translation:HumansCells
    21. Tran HT, Zhang S. Accurate prediction of the bound form of the Akt pleckstrin homology domain using normal mode analysis to explore structural flexibility. J Chem Inf Model. 2011 Sep 26; 51(9):2352-60. PMID: 21834588; PMCID: PMC3807676.
      Citations: 3     Fields:    Translation:Cells
    22. Khalaf J, Estrella-Jimenez ME, Shashack MJ, Phatak SS, Zhang S, Gilbertson SR. Design, synthesis, and diversification of 3,5-substituted enone library. ACS Comb Sci. 2011 Jul 11; 13(4):351-6. PMID: 21648460; PMCID: PMC3360050.
      Citations:    Fields:    Translation:Cells
    23. Wu B, Kulkarni K, Basu S, Zhang S, Hu M. First-pass metabolism via UDP-glucuronosyltransferase: a barrier to oral bioavailability of phenolics. J Pharm Sci. 2011 Sep; 100(9):3655-81. PMID: 21484808; PMCID: PMC3409645.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    24. Ahad AM, Zuohe S, Du-Cuny L, Moses SA, Zhou LL, Zhang S, Powis G, Meuillet EJ, Mash EA. Development of sulfonamide AKT PH domain inhibitors. Bioorg Med Chem. 2011 Mar 15; 19(6):2046-54. PMID: 21353784; PMCID: PMC3088502.
      Citations: 9     Fields:    Translation:HumansCells
    25. Morrow JK, Du-Cuny L, Chen L, Meuillet EJ, Mash EA, Powis G, Zhang S. Recent development of anticancer therapeutics targeting Akt. Recent Pat Anticancer Drug Discov. 2011 Jan; 6(1):146-59. PMID: 21110830; PMCID: PMC3784017.
      Citations: 15     Fields:    Translation:HumansAnimals
    26. Zhang S. Computer-aided drug discovery and development. Methods Mol Biol. 2011; 716:23-38. PMID: 21318898.
      Citations: 12     Fields:    
    27. Wu B, Morrow JK, Singh R, Zhang S, Hu M. Three-dimensional quantitative structure-activity relationship studies on UGT1A9-mediated 3-O-glucuronidation of natural flavonols using a pharmacophore-based comparative molecular field analysis model. J Pharmacol Exp Ther. 2011 Feb; 336(2):403-13. PMID: 21068207; PMCID: PMC3033718.
      Citations: 16     Fields:    Translation:Humans
    28. Zhang S, Chen L, Jung EJ, Calin GA. Targeting microRNAs with small molecules: from dream to reality. Clin Pharmacol Ther. 2010 Jun; 87(6):754-8. PMID: 20428111; PMCID: PMC3902962.
      Citations: 48     Fields:    Translation:HumansAnimals
    29. Meuillet EJ, Zuohe S, Lemos R, Ihle N, Kingston J, Watkins R, Moses SA, Zhang S, Du-Cuny L, Herbst R, Zhou LL, Ahad AM, Mash EA, Kirkpatrick DL, Powis G, Jacoby JJ. Molecular pharmacology and antitumor activity of PHT-427, a novel Akt/phosphatidylinositide-dependent protein kinase 1 pleckstrin homology domain inhibitor. Mol Cancer Ther. 2010 Mar; 9(3):706-17. PMID: 20197390; PMCID: PMC2837366.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    30. Morrow JK, Tian L, Zhang S. Molecular networks in drug discovery. Crit Rev Biomed Eng. 2010; 38(2):143-56. PMID: 20932236; PMCID: PMC3820486.
      Citations: 18     Fields:    Translation:Humans
    31. Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol. 2010 Mar 01; 79(5):669-77. PMID: 19814999; PMCID: PMC2812641.
      Citations: 13     Fields:    Translation:Animals
    32. Du-Cuny L, Song Z, Moses S, Powis G, Mash EA, Meuillet EJ, Zhang S. Computational modeling of novel inhibitors targeting the Akt pleckstrin homology domain. Bioorg Med Chem. 2009 Oct 01; 17(19):6983-92. PMID: 19734051; PMCID: PMC2808703.
      Citations: 16     Fields:    Translation:HumansCells
    33. Moses SA, Ali MA, Zuohe S, Du-Cuny L, Zhou LL, Lemos R, Ihle N, Skillman AG, Zhang S, Mash EA, Powis G, Meuillet EJ. In vitro and in vivo activity of novel small-molecule inhibitors targeting the pleckstrin homology domain of protein kinase B/AKT. Cancer Res. 2009 Jun 15; 69(12):5073-81. PMID: 19491272; PMCID: PMC2914301.
      Citations: 25     Fields:    Translation:AnimalsCells
    34. Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi V. Inhibition of ATP synthase by chlorinated adenosine analogue. Biochem Pharmacol. 2009 Sep 15; 78(6):583-91. PMID: 19477165; PMCID: PMC2763632.
      Citations: 17     Fields:    Translation:Cells
    35. Zhang S, Du-Cuny L. Development and evaluation of a new statistical model for structure-based high-throughput virtual screening. Int J Bioinform Res Appl. 2009; 5(3):269-79. PMID: 19525200.
      Citations: 6     Fields:    
    36. Zhang S, Kaplan AH, Tropsha A. HIV-1 protease function and structure studies with the simplicial neighborhood analysis of protein packing method. Proteins. 2008 Nov 15; 73(3):742-53. PMID: 18498108; PMCID: PMC2765824.
      Citations: 1     Fields:    Translation:Cells
    37. Mahadevan D, Powis G, Mash EA, George B, Gokhale VM, Zhang S, Shakalya K, Du-Cuny L, Berggren M, Ali MA, Jana U, Ihle N, Moses S, Franklin C, Narayan S, Shirahatti N, Meuillet EJ. Discovery of a novel class of AKT pleckstrin homology domain inhibitors. Mol Cancer Ther. 2008 Sep; 7(9):2621-32. PMID: 18790745; PMCID: PMC2727864.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    38. Zhang S, Kumar K, Jiang X, Wallqvist A, Reifman J. DOVIS: an implementation for high-throughput virtual screening using AutoDock. BMC Bioinformatics. 2008 Feb 27; 9:126. PMID: 18304355; PMCID: PMC2267697.
      Citations: 27     Fields:    Translation:Cells
    39. Niu Z, Li A, Zhang SX, Schwartz RJ. Serum response factor micromanaging cardiogenesis. Curr Opin Cell Biol. 2007 Dec; 19(6):618-27. PMID: 18023168; PMCID: PMC2735128.
      Citations: 62     Fields:    Translation:HumansAnimals
    40. Zhang S, Wei L, Bastow K, Zheng W, Brossi A, Lee KH, Tropsha A. Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. J Comput Aided Mol Des. 2007 Jan-Mar; 21(1-3):97-112. PMID: 17340042; PMCID: PMC2754562.
      Citations: 16     Fields:    
    41. Zhang S, Golbraikh A, Oloff S, Kohn H, Tropsha A. A novel automated lazy learning QSAR (ALL-QSAR) approach: method development, applications, and virtual screening of chemical databases using validated ALL-QSAR models. J Chem Inf Model. 2006 Sep-Oct; 46(5):1984-95. PMID: 16995729; PMCID: PMC2536695.
      Citations: 43     Fields:    
    42. Zhang S, Golbraikh A, Tropsha A. Development of quantitative structure-binding affinity relationship models based on novel geometrical chemical descriptors of the protein-ligand interfaces. J Med Chem. 2006 May 04; 49(9):2713-24. PMID: 16640331; PMCID: PMC2773514.
      Citations: 26     Fields:    Translation:Cells
    43. Oloff S, Zhang S, Sukumar N, Breneman C, Tropsha A. Chemometric analysis of ligand receptor complementarity: identifying Complementary Ligands Based on Receptor Information (CoLiBRI). J Chem Inf Model. 2006 Mar-Apr; 46(2):844-51. PMID: 16563016; PMCID: PMC2755506.
      Citations: 15     Fields:    Translation:Cells
    44. Miller BM, Zhang S, Suggs JA, Swank DM, Littlefield KP, Knowles AF, Bernstein SI. An alternative domain near the nucleotide-binding site of Drosophila muscle myosin affects ATPase kinetics. J Mol Biol. 2005 Oct 14; 353(1):14-25. PMID: 16154586.
      Citations: 13     Fields:    Translation:AnimalsCells
    45. Chi X, Chatterjee PK, Wilson W, Zhang SX, Demayo FJ, Schwartz RJ. Complex cardiac Nkx2-5 gene expression activated by noggin-sensitive enhancers followed by chamber-specific modules. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13490-5. PMID: 16150722; PMCID: PMC1224629.
      Citations: 14     Fields:    Translation:AnimalsCells
    46. Niu Z, Yu W, Zhang SX, Barron M, Belaguli NS, Schneider MD, Parmacek M, Nordheim A, Schwartz RJ. Conditional mutagenesis of the murine serum response factor gene blocks cardiogenesis and the transcription of downstream gene targets. J Biol Chem. 2005 Sep 16; 280(37):32531-8. PMID: 15929941.
      Citations: 56     Fields:    Translation:AnimalsCells
    47. Zhang SX, Garcia-Gras E, Wycuff DR, Marriot SJ, Kadeer N, Yu W, Olson EN, Garry DJ, Parmacek MS, Schwartz RJ. Identification of direct serum-response factor gene targets during Me2SO-induced P19 cardiac cell differentiation. J Biol Chem. 2005 May 13; 280(19):19115-26. PMID: 15699019.
      Citations: 43     Fields:    Translation:AnimalsCells
    48. Sherman DB, Zhang S, Pitner JB, Tropsha A. Evaluation of the relative stability of liganded versus ligand-free protein conformations using Simplicial Neighborhood Analysis of Protein Packing (SNAPP) method. Proteins. 2004 Sep 01; 56(4):828-38. PMID: 15281134; PMCID: PMC2778290.
      Citations: 4     Fields:    Translation:Cells
    49. Shuxing Z, Ying WS, Siahaan TJ, Jois SD. Solution structure of a peptide derived from the beta subunit of LFA-1. Peptides. 2003 Jun; 24(6):827-35. PMID: 12948834.
      Citations: 2     Fields:    Translation:Cells
    50. Chi X, Zhang SX, Yu W, DeMayo FJ, Rosenberg SM, Schwartz RJ. Expression of Nkx2-5-GFP bacterial artificial chromosome transgenic mice closely resembles endogenous Nkx2-5 gene activity. Genesis. 2003 Apr; 35(4):220-6. PMID: 12717733.
      Citations: 8     Fields:    Translation:AnimalsCells
    51. Wei L, Roberts W, Wang L, Yamada M, Zhang S, Zhao Z, Rivkees SA, Schwartz RJ, Imanaka-Yoshida K. Rho kinases play an obligatory role in vertebrate embryonic organogenesis. Development. 2001 Aug; 128(15):2953-62. PMID: 11532918.
      Citations: 85     Fields:    Translation:Animals
    52. Zhang S, Bernstein SI. Spatially and temporally regulated expression of myosin heavy chain alternative exons during Drosophila embryogenesis. Mech Dev. 2001 Mar; 101(1-2):35-45. PMID: 11231057.
      Citations: 39     Fields:    Translation:AnimalsCells
    53. Langlais PJ, Zhang SX. Cortical and subcortical white matter damage without Wernicke's encephalopathy after recovery from thiamine deficiency in the rat. Alcohol Clin Exp Res. 1997 05; 21(3):434-43. PMID: 9161603.
      Citations: 29     Fields:    Translation:Animals
    54. Langlais PJ, Zhang SX, Savage LM. Neuropathology of thiamine deficiency: an update on the comparative analysis of human disorders and experimental models. Metab Brain Dis. 1996 Mar; 11(1):19-37. PMID: 8815388.
      Citations: 28     Fields:    Translation:HumansAnimals
    55. Zhang SX, Weilersbacher GS, Henderson SW, Corso T, Olney JW, Langlais PJ. Excitotoxic cytopathology, progression, and reversibility of thiamine deficiency-induced diencephalic lesions. J Neuropathol Exp Neurol. 1995 Mar; 54(2):255-67. PMID: 7876893.
      Citations: 31     Fields:    Translation:Animals
    56. Langlais PJ, Zhang SX, Weilersbacher G, Hough LB, Barke KE. Histamine-mediated neuronal death in a rat model of Wernicke's encephalopathy. J Neurosci Res. 1994 Aug 01; 38(5):565-74. PMID: 7529327.
      Citations: 10     Fields:    Translation:AnimalsCells
    57. Langlais PJ, Zhang SX. Extracellular glutamate is increased in thalamus during thiamine deficiency-induced lesions and is blocked by MK-801. J Neurochem. 1993 Dec; 61(6):2175-82. PMID: 8245970.
      Citations: 39     Fields:    Translation:AnimalsCells
    58. Targeting ubiquitination for cancer therapies. Future Medicinal Chemistry. 7:2333-2350.
    59. Erratum. Journal of Natural Products. 59:1002.
    60. Past, present, and future of targeting ras for cancer therapies. Mini-Reviews in Medicinal Chemistry. 16:345-357.
    61. Novel computational biology methods and their applications to drug discovery. Frontiers of Biology in China. 6:289-299.
    62. The elephant in the room. Mini-Reviews in Medicinal Chemistry. 16:343-344.
    63. Correction. Journal of Biological Chemistry. 291:16926.
    64. Mapping drug-target interaction networks. 2336-2339.
    65. Comprehensive modeling and discovery of mebendazole as a novel TRAF2- and NCK-interacting kinase inhibitor. Scientific Reports. 6.
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