XIN LIN

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pan D, Zhu Y, Zhou Z, Wang T, You H, Jiang C, Lin X. The CBM Complex Underwrites NF-?B Activation to Promote HER2-Associated Tumor Malignancy. Mol Cancer Res. 2016 Jan; 14(1):93-102. PMID: 26392569.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    2. Phan L, Chou PC, Velazquez-Torres G, Samudio I, Parreno K, Huang Y, Tseng C, Vu T, Gully C, Su CH, Wang E, Chen J, Choi HH, Fuentes-Mattei E, Shin JH, Shiang C, Grabiner B, Blonska M, Skerl S, Shao Y, Cody D, Delacerda J, Kingsley C, Webb D, Carlock C, Zhou Z, Hsieh YC, Lee J, Elliott A, Ramirez M, Bankson J, Hazle J, Wang Y, Li L, Weng S, Rizk N, Wen YY, Lin X, Wang H, Wang H, Zhang A, Xia X, Wu Y, Habra M, Yang W, Pusztai L, Yeung SC, Lee MH. The cell cycle regulator 14-3-3s opposes and reverses cancer metabolic reprogramming. Nat Commun. 2015 Jul 16; 6:7530. PMID: 26179207.
      Citations: 32     Fields:    Translation:HumansCells
    3. Jiang C, Lin X. Analysis of epidermal growth factor-induced NF-?B signaling. Methods Mol Biol. 2015; 1280:75-102. PMID: 25736745.
      Citations: 5     Fields:    Translation:HumansCells
    4. Blonska M, Zhu Y, Chuang HH, You MJ, Kunkalla K, Vega F, Lin X. Jun-regulated genes promote interaction of diffuse large B-cell lymphoma with the microenvironment. Blood. 2015 Feb 05; 125(6):981-91. PMID: 25533033.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    5. Jia XM, Tang B, Zhu LL, Liu YH, Zhao XQ, Gorjestani S, Hsu YM, Yang L, Guan JH, Xu GT, Lin X. CARD9 mediates Dectin-1-induced ERK activation by linking Ras-GRF1 to H-Ras for antifungal immunity. J Exp Med. 2014 Oct 20; 211(11):2307-21. PMID: 25267792.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    6. Zhao XQ, Zhu LL, Chang Q, Jiang C, You Y, Luo T, Jia XM, Lin X. C-type lectin receptor dectin-3 mediates trehalose 6,6'-dimycolate (TDM)-induced Mincle expression through CARD9/Bcl10/MALT1-dependent nuclear factor (NF)-?B activation. J Biol Chem. 2014 Oct 24; 289(43):30052-62. PMID: 25202022.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    7. Nakaya M, Xiao Y, Zhou X, Chang JH, Chang M, Cheng X, Blonska M, Lin X, Sun SC. Inflammatory T cell responses rely on amino acid transporter ASCT2 facilitation of glutamine uptake and mTORC1 kinase activation. Immunity. 2014 May 15; 40(5):692-705. PMID: 24792914.
      Citations: 250     Fields:    Translation:HumansAnimalsCells
    8. Cheng Q, Zhang Q, Xu X, Yin L, Sun L, Lin X, Dong C, Pan W. MAPK phosphotase 5 deficiency contributes to protection against blood-stage Plasmodium yoelii 17XL infection in mice. J Immunol. 2014 Apr 15; 192(8):3686-96. PMID: 24634491.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Wang H, LeBert V, Hung CY, Galles K, Saijo S, Lin X, Cole GT, Klein BS, Wüthrich M. C-type lectin receptors differentially induce th17 cells and vaccine immunity to the endemic mycosis of North America. J Immunol. 2014 Feb 01; 192(3):1107-1119. PMID: 24391211.
      Citations: 48     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Blonska M, Joo D, Nurieva RI, Zhao X, Chiao P, Sun SC, Dong C, Lin X. Activation of the transcription factor c-Maf in T cells is dependent on the CARMA1-IKKß signaling cascade. Sci Signal. 2013 Dec 17; 6(306):ra110. PMID: 24345681.
      Citations: 5     Fields:    Translation:HumansCells
    11. Pan D, Lin X. Epithelial growth factor receptor-activated nuclear factor ?B signaling and its role in epithelial growth factor receptor-associated tumors. Cancer J. 2013 Nov-Dec; 19(6):461-7. PMID: 24270344.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    12. Su SC, Hu X, Kenney PA, Merrill MM, Babaian KN, Zhang XY, Maity T, Yang SF, Lin X, Wood CG. Autotaxin-lysophosphatidic acid signaling axis mediates tumorigenesis and development of acquired resistance to sunitinib in renal cell carcinoma. Clin Cancer Res. 2013 Dec 01; 19(23):6461-72. PMID: 24122794.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    13. Zhang L, Pham LV, Newberry KJ, Ou Z, Liang R, Qian J, Sun L, Blonska M, You Y, Yang J, Lin X, Rollo A, Tamayo AT, Lee J, Ford RJ, Zhao X, Kwak LW, Yi Q, Wang M. In vitro and in vivo therapeutic efficacy of carfilzomib in mantle cell lymphoma: targeting the immunoproteasome. Mol Cancer Ther. 2013 Nov; 12(11):2494-504. PMID: 23990113.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    14. Zhu LL, Zhao XQ, Jiang C, You Y, Chen XP, Jiang YY, Jia XM, Lin X. C-type lectin receptors Dectin-3 and Dectin-2 form a heterodimeric pattern-recognition receptor for host defense against fungal infection. Immunity. 2013 Aug 22; 39(2):324-34. PMID: 23911656.
      Citations: 124     Fields:    Translation:HumansAnimalsCells
    15. Liu X, Li H, Zhong B, Blonska M, Gorjestani S, Yan M, Tian Q, Zhang DE, Lin X, Dong C. USP18 inhibits NF-?B and NFAT activation during Th17 differentiation by deubiquitinating the TAK1-TAB1 complex. J Exp Med. 2013 Jul 29; 210(8):1575-90. PMID: 23825189.
      Citations: 42     Fields:    Translation:AnimalsCells
    16. Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z. Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 05; 288(27):19321-9. PMID: 23678002.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    17. Zhong B, Liu X, Wang X, Liu X, Li H, Darnay BG, Lin X, Sun SC, Dong C. Ubiquitin-specific protease 25 regulates TLR4-dependent innate immune responses through deubiquitination of the adaptor protein TRAF3. Sci Signal. 2013 May 14; 6(275):ra35. PMID: 23674823.
      Citations: 38     Fields:    Translation:AnimalsCells
    18. Qu C, Liu Y, Kunkalla K, Singh RR, Blonska M, Lin X, Agarwal NK, Vega F. Trimeric G protein-CARMA1 axis links smoothened, the hedgehog receptor transducer, to NF-?B activation in diffuse large B-cell lymphoma. Blood. 2013 Jun 06; 121(23):4718-28. PMID: 23632891.
      Citations: 9     Fields:    Translation:HumansCells
    19. Shenderov K, Barber DL, Mayer-Barber KD, Gurcha SS, Jankovic D, Feng CG, Oland S, Hieny S, Caspar P, Yamasaki S, Lin X, Ting JP, Trinchieri G, Besra GS, Cerundolo V, Sher A. Cord factor and peptidoglycan recapitulate the Th17-promoting adjuvant activity of mycobacteria through mincle/CARD9 signaling and the inflammasome. J Immunol. 2013 Jun 01; 190(11):5722-30. PMID: 23630357.
      Citations: 52     Fields:    Translation:AnimalsCells
    20. Jhingran A, Mar KB, Kumasaka DK, Knoblaugh SE, Ngo LY, Segal BH, Iwakura Y, Lowell CA, Hamerman JA, Lin X, Hohl TM. Tracing conidial fate and measuring host cell antifungal activity using a reporter of microbial viability in the lung. Cell Rep. 2012 Dec 27; 2(6):1762-73. PMID: 23200858.
      Citations: 58     Fields:    Translation:AnimalsCells
    21. Blonska M, Lin X. Dampening NF-?B signaling by "self-eating". Immunity. 2012 Jun 29; 36(6):895-6. PMID: 22749346.
      Citations:    Fields:    
    22. Yang CS, Rodgers M, Min CK, Lee JS, Kingeter L, Lee JY, Jong A, Kramnik I, Lin X, Jung JU. The autophagy regulator Rubicon is a feedback inhibitor of CARD9-mediated host innate immunity. Cell Host Microbe. 2012 Mar 15; 11(3):277-89. PMID: 22423967.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    23. Jiang C, Lin X. Regulation of NF-?B by the CARD proteins. Immunol Rev. 2012 Mar; 246(1):141-53. PMID: 22435552.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    24. Blonska M, Joo D, Zweidler-McKay PA, Zhao Q, Lin X. CARMA1 controls Th2 cell-specific cytokine expression through regulating JunB and GATA3 transcription factors. J Immunol. 2012 Apr 01; 188(7):3160-8. PMID: 22371397.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    25. Kingeter LM, Lin X. C-type lectin receptor-induced NF-?B activation in innate immune and inflammatory responses. Cell Mol Immunol. 2012 Mar; 9(2):105-12. PMID: 22246129.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    26. Wang J, Ray PS, Sim MS, Zhou XZ, Lu KP, Lee AV, Lin X, Bagaria SP, Giuliano AE, Cui X. FOXC1 regulates the functions of human basal-like breast cancer cells by activating NF-?B signaling. Oncogene. 2012 Nov 08; 31(45):4798-802. PMID: 22249250.
      Citations: 54     Fields:    Translation:HumansCells
    27. Gorjestani S, Yu M, Tang B, Zhang D, Wang D, Lin X. Phospholipase C?2 (PLC?2) is key component in Dectin-2 signaling pathway, mediating anti-fungal innate immune responses. J Biol Chem. 2011 Dec 23; 286(51):43651-43659. PMID: 22041900.
      Citations: 22     Fields:    Translation:AnimalsCells
    28. Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung MC, Lin X. CARMA3 is crucial for EGFR-Induced activation of NF-?B and tumor progression. Cancer Res. 2011 Mar 15; 71(6):2183-92. PMID: 21406399.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    29. Blonska M, Lin X. NF-?B signaling pathways regulated by CARMA family of scaffold proteins. Cell Res. 2011 Jan; 21(1):55-70. PMID: 21187856.
      Citations: 89     Fields:    Translation:HumansCells
    30. Qu Y, Wang J, Ray PS, Guo H, Huang J, Shin-Sim M, Bukoye BA, Liu B, Lee AV, Lin X, Huang P, Martens JW, Giuliano AE, Zhang N, Cheng NH, Cui X. Thioredoxin-like 2 regulates human cancer cell growth and metastasis via redox homeostasis and NF-?B signaling. J Clin Invest. 2011 Jan; 121(1):212-25. PMID: 21123948.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    31. Bi L, Gojestani S, Wu W, Hsu YM, Zhu J, Ariizumi K, Lin X. CARD9 mediates dectin-2-induced IkappaBalpha kinase ubiquitination leading to activation of NF-kappaB in response to stimulation by the hyphal form of Candida albicans. J Biol Chem. 2010 Aug 20; 285(34):25969-77. PMID: 20538615.
      Citations: 48     Fields:    Translation:AnimalsCells
    32. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28; 32(5):670-80. PMID: 20493730.
      Citations: 70     Fields:    Translation:AnimalsCells
    33. Wu W, Hsu YM, Bi L, Songyang Z, Lin X. CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol. 2009 Nov; 10(11):1208-14. PMID: 19767757.
      Citations: 40     Fields:    Translation:AnimalsCells
    34. Yang WL, Wang J, Chan CH, Lee SW, Campos AD, Lamothe B, Hur L, Grabiner BC, Lin X, Darnay BG, Lin HK. The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science. 2009 Aug 28; 325(5944):1134-8. PMID: 19713527.
      Citations: 269     Fields:    Translation:HumansAnimalsCells
    35. Sun W, Li H, Yu Y, Fan Y, Grabiner BC, Mao R, Ge N, Zhang H, Fu S, Lin X, Yang J. MEKK3 is required for lysophosphatidic acid-induced NF-kappaB activation. Cell Signal. 2009 Oct; 21(10):1488-94. PMID: 19465115.
      Citations: 14     Fields:    Translation:AnimalsCells
    36. Blonska M, Lin X. CARMA1-mediated NF-kappaB and JNK activation in lymphocytes. Immunol Rev. 2009 Mar; 228(1):199-211. PMID: 19290929.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    37. Goodridge HS, Shimada T, Wolf AJ, Hsu YM, Becker CA, Lin X, Underhill DM. Differential use of CARD9 by dectin-1 in macrophages and dendritic cells. J Immunol. 2009 Jan 15; 182(2):1146-54. PMID: 19124758.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    38. Nadiminty N, Chun JY, Lou W, Lin X, Gao AC. NF-kappaB2/p52 enhances androgen-independent growth of human LNCaP cells via protection from apoptotic cell death and cell cycle arrest induced by androgen-deprivation. Prostate. 2008 Dec 01; 68(16):1725-33. PMID: 18781579.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    39. Sun J, Lin X. Beta-arrestin 2 is required for lysophosphatidic acid-induced NF-kappaB activation. Proc Natl Acad Sci U S A. 2008 Nov 04; 105(44):17085-90. PMID: 18952848.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    40. Yang H, Gu J, Lin X, Grossman HB, Ye Y, Dinney CP, Wu X. Profiling of genetic variations in inflammation pathway genes in relation to bladder cancer predisposition. Clin Cancer Res. 2008 Apr 01; 14(7):2236-44. PMID: 18381966.
      Citations: 25     Fields:    Translation:Humans
    41. Li H, Lin X. Positive and negative signaling components involved in TNFalpha-induced NF-kappaB activation. Cytokine. 2008 Jan; 41(1):1-8. PMID: 18068998.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    42. Lin X, Wood CG, Shao L, Huang M, Yang H, Dinney CP, Wu X. Risk assessment of renal cell carcinoma using alkaline comet assay. Cancer. 2007 Jul 15; 110(2):282-8. PMID: 17549681.
      Citations: 3     Fields:    Translation:Humans
    43. Nadiminty N, Chun JY, Hu Y, Dutt S, Lin X, Gao AC. LIGHT, a member of the TNF superfamily, activates Stat3 mediated by NIK pathway. Biochem Biophys Res Commun. 2007 Jul 27; 359(2):379-84. PMID: 17543278.
      Citations: 17     Fields:    Translation:HumansCells
    44. Zeng H, Di L, Fu G, Chen Y, Gao X, Xu L, Lin X, Wen R. Phosphorylation of Bcl10 negatively regulates T-cell receptor-mediated NF-kappaB activation. Mol Cell Biol. 2007 Jul; 27(14):5235-45. PMID: 17502353.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    45. Grabiner BC, Blonska M, Lin PC, You Y, Wang D, Sun J, Darnay BG, Dong C, Lin X. CARMA3 deficiency abrogates G protein-coupled receptor-induced NF-{kappa}B activation. Genes Dev. 2007 Apr 15; 21(8):984-96. PMID: 17438001.
      Citations: 65     Fields:    Translation:AnimalsCells
    46. Tanner MJ, Hanel W, Gaffen SL, Lin X. CARMA1 coiled-coil domain is involved in the oligomerization and subcellular localization of CARMA1 and is required for T cell receptor-induced NF-kappaB activation. J Biol Chem. 2007 Jun 08; 282(23):17141-7. PMID: 17428801.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    47. Shambharkar PB, Blonska M, Pappu BP, Li H, You Y, Sakurai H, Darnay BG, Hara H, Penninger J, Lin X. Phosphorylation and ubiquitination of the IkappaB kinase complex by two distinct signaling pathways. EMBO J. 2007 Apr 04; 26(7):1794-805. PMID: 17363905.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    48. Kim HJ, Litzenburger BC, Cui X, Delgado DA, Grabiner BC, Lin X, Lewis MT, Gottardis MM, Wong TW, Attar RM, Carboni JM, Lee AV. Constitutively active type I insulin-like growth factor receptor causes transformation and xenograft growth of immortalized mammary epithelial cells and is accompanied by an epithelial-to-mesenchymal transition mediated by NF-kappaB and snail. Mol Cell Biol. 2007 Apr; 27(8):3165-75. PMID: 17296734.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    49. Ohnuma K, Uchiyama M, Yamochi T, Nishibashi K, Hosono O, Takahashi N, Kina S, Tanaka H, Lin X, Dang NH, Morimoto C. Caveolin-1 triggers T-cell activation via CD26 in association with CARMA1. J Biol Chem. 2007 Mar 30; 282(13):10117-10131. PMID: 17287217.
      Citations: 46     Fields:    Translation:HumansCells
    50. Wu X, Lin X, Dinney CP, Gu J, Grossman HB. Genetic polymorphism in bladder cancer. Front Biosci. 2007 Jan 01; 12:192-213. PMID: 17127293.
      Citations: 10     Fields:    Translation:HumansCells
    51. Huang M, Dinney CP, Lin X, Lin J, Grossman HB, Wu X. High-order interactions among genetic variants in DNA base excision repair pathway genes and smoking in bladder cancer susceptibility. Cancer Epidemiol Biomarkers Prev. 2007 Jan; 16(1):84-91. PMID: 17220334.
      Citations: 43     Fields:    Translation:HumansCells
    52. Chen Y, Pappu BP, Zeng H, Xue L, Morris SW, Lin X, Wen R, Wang D. B cell lymphoma 10 is essential for FcepsilonR-mediated degranulation and IL-6 production in mast cells. J Immunol. 2007 Jan 01; 178(1):49-57. PMID: 17182539.
      Citations: 10     Fields:    Translation:AnimalsCells
    53. Blonska M, Pappu BP, Matsumoto R, Li H, Su B, Wang D, Lin X. The CARMA1-Bcl10 signaling complex selectively regulates JNK2 kinase in the T cell receptor-signaling pathway. Immunity. 2007 Jan; 26(1):55-66. PMID: 17189706.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    54. Hsu YM, Zhang Y, You Y, Wang D, Li H, Duramad O, Qin XF, Dong C, Lin X. The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat Immunol. 2007 Feb; 8(2):198-205. PMID: 17187069.
      Citations: 175     Fields:    Translation:AnimalsCells
    55. Wang D, You Y, Lin PC, Xue L, Morris SW, Zeng H, Wen R, Lin X. Bcl10 plays a critical role in NF-kappaB activation induced by G protein-coupled receptors. Proc Natl Acad Sci U S A. 2007 Jan 02; 104(1):145-50. PMID: 17179215.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    56. Pappu BP, Lin X. Potential role of CARMA1 in CD40-induced splenic B cell proliferation and marginal zone B cell maturation. Eur J Immunol. 2006 Nov; 36(11):3033-43. PMID: 17048267.
      Citations: 10     Fields:    Translation:AnimalsCells
    57. Lin X, Gu J, Lu C, Spitz MR, Wu X. Expression of telomere-associated genes as prognostic markers for overall survival in patients with non-small cell lung cancer. Clin Cancer Res. 2006 Oct 01; 12(19):5720-5. PMID: 17020976.
      Citations: 18     Fields:    Translation:HumansCells
    58. Jackson-Bernitsas DG, Ichikawa H, Takada Y, Myers JN, Lin XL, Darnay BG, Chaturvedi MM, Aggarwal BB. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007 Mar 01; 26(10):1385-97. PMID: 16953224.
      Citations: 78     Fields:    Translation:HumansCells
    59. Dong MJ, Lin XT, Zhao J, Guan YH, Zuo CT, Chen X, Dai JZ, Jiang BD. [Malignant tumor with false negative 18F-FDG PET image]. Zhonghua Zhong Liu Za Zhi. 2006 Sep; 28(9):713-7. PMID: 17274383.
      Citations: 2     Fields:    Translation:Humans
    60. Sethi G, Ahn KS, Sandur SK, Lin X, Chaturvedi MM, Aggarwal BB. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006 Aug 18; 281(33):23425-35. PMID: 16785236.
      Citations: 30     Fields:    Translation:HumansCells
    61. Gu J, Wu X, Dong Q, Romeo MJ, Lin X, Gutkind JS, Berman DM. A nonsynonymous single-nucleotide polymorphism in the PDZ-Rho guanine nucleotide exchange factor (Ser1416Gly) modulates the risk of lung cancer in Mexican Americans. Cancer. 2006 Jun 15; 106(12):2716-24. PMID: 16691626.
      Citations: 10     Fields:    Translation:HumansCells
    62. Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 09; 103(19):7264-9. PMID: 16651533.
      Citations: 58     Fields:    Translation:HumansCells
    63. Li H, Kobayashi M, Blonska M, You Y, Lin X. Ubiquitination of RIP is required for tumor necrosis factor alpha-induced NF-kappaB activation. J Biol Chem. 2006 May 12; 281(19):13636-13643. PMID: 16543241.
      Citations: 101     Fields:    Translation:HumansCells
    64. Matsumoto R, Wang D, Blonska M, Li H, Kobayashi M, Pappu B, Chen Y, Wang D, Lin X. Phosphorylation of CARMA1 plays a critical role in T Cell receptor-mediated NF-kappaB activation. Immunity. 2005 Dec; 23(6):575-85. PMID: 16356856.
      Citations: 140     Fields:    Translation:HumansAnimalsCells
    65. Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, Su B, Lin X. TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem. 2005 Dec 30; 280(52):43056-63. PMID: 16260783.
      Citations: 40     Fields:    Translation:HumansCells
    66. Lee SO, Lou W, Nadiminty N, Lin X, Gao AC. Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells. Prostate. 2005 Jul 01; 64(2):160-7. PMID: 15678501.
      Citations: 25     Fields:    Translation:HumansCells
    67. Blonska M, You Y, Geleziunas R, Lin X. Restoration of NF-kappaB activation by tumor necrosis factor alpha receptor complex-targeted MEKK3 in receptor-interacting protein-deficient cells. Mol Cell Biol. 2004 Dec; 24(24):10757-65. PMID: 15572679.
      Citations: 17     Fields:    Translation:HumansCells
    68. Lin X, Wang D. The roles of CARMA1, Bcl10, and MALT1 in antigen receptor signaling. Semin Immunol. 2004 Dec; 16(6):429-35. PMID: 15541657.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    69. Liu XK, Lin X, Gaffen SL. Crucial role for nuclear factor of activated T cells in T cell receptor-mediated regulation of human interleukin-17. J Biol Chem. 2004 Dec 10; 279(50):52762-71. PMID: 15459204.
      Citations: 57     Fields:    Translation:HumansCells
    70. Che T, You Y, Wang D, Tanner MJ, Dixit VM, Lin X. MALT1/paracaspase is a signaling component downstream of CARMA1 and mediates T cell receptor-induced NF-kappaB activation. J Biol Chem. 2004 Apr 16; 279(16):15870-6. PMID: 14754896.
      Citations: 44     Fields:    Translation:HumansCells
    71. Wang D, Matsumoto R, You Y, Che T, Lin XY, Gaffen SL, Lin X. CD3/CD28 costimulation-induced NF-kappaB activation is mediated by recruitment of protein kinase C-theta, Bcl10, and IkappaB kinase beta to the immunological synapse through CARMA1. Mol Cell Biol. 2004 Jan; 24(1):164-71. PMID: 14673152.
      Citations: 88     Fields:    Translation:HumansCells
    72. Lin X, Irwin D, Kanazawa S, Huang L, Romeo J, Yen TS, Peterlin BM. Transcriptional profiles of latent human immunodeficiency virus in infected individuals: effects of Tat on the host and reservoir. J Virol. 2003 Aug; 77(15):8227-36. PMID: 12857891.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    73. Wang D, You Y, Case SM, McAllister-Lucas LM, Wang L, DiStefano PS, Nuñez G, Bertin J, Lin X. A requirement for CARMA1 in TCR-induced NF-kappa B activation. Nat Immunol. 2002 Sep; 3(9):830-5. PMID: 12154356.
      Citations: 128     Fields:    Translation:HumansCells
    74. Lin X, Taube R, Fujinaga K, Peterlin BM. P-TEFb containing cyclin K and Cdk9 can activate transcription via RNA. J Biol Chem. 2002 May 10; 277(19):16873-8. PMID: 11884399.
      Citations: 30     Fields:    Translation:HumansCells
    75. Taube R, Lin X, Irwin D, Fujinaga K, Peterlin BM. Interaction between P-TEFb and the C-terminal domain of RNA polymerase II activates transcriptional elongation from sites upstream or downstream of target genes. Mol Cell Biol. 2002 Jan; 22(1):321-31. PMID: 11739744.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    76. Foehr ED, Bohuslav J, Chen LF, DeNoronha C, Geleziunas R, Lin X, O'Mahony A, Greene WC. The NF-kappa B-inducing kinase induces PC12 cell differentiation and prevents apoptosis. J Biol Chem. 2000 Nov 03; 275(44):34021-4. PMID: 10980190.
      Citations: 23     Fields:    Translation:AnimalsCells
    77. Foehr ED, Lin X, O'Mahony A, Geleziunas R, Bradshaw RA, Greene WC. NF-kappa B signaling promotes both cell survival and neurite process formation in nerve growth factor-stimulated PC12 cells. J Neurosci. 2000 Oct 15; 20(20):7556-63. PMID: 11027214.
      Citations: 41     Fields:    Translation:AnimalsCells
    78. Lin X, Wei G, Shi Z, Dryer L, Esko JD, Wells DE, Matzuk MM. Disruption of gastrulation and heparan sulfate biosynthesis in EXT1-deficient mice. Dev Biol. 2000 Aug 15; 224(2):299-311. PMID: 10926768.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    79. Lin X, O'Mahony A, Mu Y, Geleziunas R, Greene WC. Protein kinase C-theta participates in NF-kappaB activation induced by CD3-CD28 costimulation through selective activation of IkappaB kinase beta. Mol Cell Biol. 2000 Apr; 20(8):2933-40. PMID: 10733597.
      Citations: 75     Fields:    Translation:HumansCells
    80. O'Mahony A, Lin X, Geleziunas R, Greene WC. Activation of the heterodimeric IkappaB kinase alpha (IKKalpha)-IKKbeta complex is directional: IKKalpha regulates IKKbeta under both basal and stimulated conditions. Mol Cell Biol. 2000 Feb; 20(4):1170-8. PMID: 10648602.
      Citations: 37     Fields:    Translation:HumansCells
    81. Lin X, Wells DE, Kimberling WJ, Kumar S. Human NDUFB9 gene: genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. Hum Hered. 1999 Mar; 49(2):75-80. PMID: 10077726.
      Citations: 5     Fields:    Translation:HumansCells
    82. Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC. The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases. Immunity. 1999 Feb; 10(2):271-80. PMID: 10072079.
      Citations: 50     Fields:    Translation:HumansCells
    83. Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC. Molecular determinants of NF-kappaB-inducing kinase action. Mol Cell Biol. 1998 Oct; 18(10):5899-907. PMID: 9742107.
      Citations: 40     Fields:    Translation:HumansCells
    84. Geleziunas R, Ferrell S, Lin X, Mu Y, Cunningham ET, Grant M, Connelly MA, Hambor JE, Marcu KB, Greene WC. Human T-cell leukemia virus type 1 Tax induction of NF-kappaB involves activation of the IkappaB kinase alpha (IKKalpha) and IKKbeta cellular kinases. Mol Cell Biol. 1998 Sep; 18(9):5157-65. PMID: 9710600.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    85. Lin X, Gan L, Klein WH, Wells D. Expression and functional analysis of mouse EXT1, a homolog of the human multiple exostoses type 1 gene. Biochem Biophys Res Commun. 1998 Jul 30; 248(3):738-43. PMID: 9703997.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    86. Lin X, Wells DE. Localization of the human H3F3A histone gene to 1q41, outside of the normal histone gene clusters. Genomics. 1997 Dec 15; 46(3):526-8. PMID: 9441765.
      Citations: 2     Fields:    Translation:HumansCells
    87. Ghoda L, Lin X, Greene WC. The 90-kDa ribosomal S6 kinase (pp90rsk) phosphorylates the N-terminal regulatory domain of IkappaBalpha and stimulates its degradation in vitro. J Biol Chem. 1997 Aug 22; 272(34):21281-8. PMID: 9261139.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    88. Wells DE, Hill A, Lin X, Ahn J, Brown N, Wagner MJ. Identification of novel mutations in the human EXT1 tumor suppressor gene. Hum Genet. 1997 May; 99(5):612-5. PMID: 9150727.
      Citations: 7     Fields:    Translation:HumansCells
    89. Lüdecke HJ, Ahn J, Lin X, Hill A, Wagner MJ, Schomburg L, Horsthemke B, Wells DE. Genomic organization and promoter structure of the human EXT1 gene. Genomics. 1997 Mar 01; 40(2):351-4. PMID: 9119404.
      Citations: 15     Fields:    Translation:HumansCells
    90. Putkey JA, Liu W, Lin X, Ahmed S, Zhang M, Potter JD, Kerrick WG. Fluorescent probes attached to Cys 35 or Cys 84 in cardiac troponin C are differentially sensitive to Ca(2+)-dependent events in vitro and in situ. Biochemistry. 1997 Jan 28; 36(4):970-8. PMID: 9020797.
      Citations: 24     Fields:    Translation:AnimalsCells
    91. Lin X, Wells D. Isolation of the mouse cDNA homologous to the human EXT1 gene responsible for Hereditary Multiple Exostoses. DNA Seq. 1997; 7(3-4):199-202. PMID: 9254013.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    92. Gu JZ, Lin X, Wells DE. The human B22 subunit of the NADH-ubiquinone oxidoreductase maps to the region of chromosome 8 involved in branchio-oto-renal syndrome. Genomics. 1996 Jul 01; 35(1):6-10. PMID: 8661098.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    93. Lin X, Dotson DG, Putkey JA. Covalent binding of peptides to the N-terminal hydrophobic region of cardiac troponin C has limited effects on function. J Biol Chem. 1996 Jan 05; 271(1):244-9. PMID: 8550567.
      Citations: 3     Fields:    Translation:AnimalsCells
    94. Howarth JW, Krudy GA, Lin X, Putkey JA, Rosevear PR. An NMR and spin label study of the effects of binding calcium and troponin I inhibitory peptide to cardiac troponin C. Protein Sci. 1995 Apr; 4(4):671-80. PMID: 7613465.
      Citations: 7     Fields:    Translation:Cells
    95. Lin X, Krudy GA, Howarth J, Brito RM, Rosevear PR, Putkey JA. Assignment and calcium dependence of methionyl epsilon C and epsilon H resonances in cardiac troponin C. Biochemistry. 1994 Dec 06; 33(48):14434-42. PMID: 7981203.
      Citations: 9     Fields:    Translation:Cells
    96. Liu W, Dotson DG, Lin X, Mullen JJ, Gonzalez-Garay ML, Lu Q, Putkey JA. The presence but not the sequence of the N-terminal peptide in cardiac TnC is important for function. FEBS Lett. 1994 Jun 27; 347(2-3):152-6. PMID: 8033994.
      Citations: 1     Fields:    Translation:AnimalsCells
    97. Dectin-3 Deficiency Promotes Colitis Development due to Impaired Antifungal Innate Immune Responses in the Gut. PLoS Pathogens. 12.
    98. Nature Communications. 6.
    99. CARD9-Dependent Neutrophil Recruitment Protects against Fungal Invasion of the Central Nervous System. PLoS Pathogens. 11.
    100. Phosphoinositide 3-kinase d regulates dectin-2 signaling and the generation of Th2 and Th17 immunity. Journal of Immunology. 197:278-287.
    101. PKC-δ activation in neutrophils promotes fungal clearance. Journal of Leukocyte Biology. 100:581-588.
    102. Regulation of linear ubiquitin chain assembly complex by caspase-mediated cleavage of RNF31. Molecular and Cellular Biology. 36:3010-3018.
    103. E3 ubiquitin ligase Cbl-b negatively regulates C-type lectin receptor-mediated antifungal innate immunity. Journal of Experimental Medicine. 213:1555-1570.
    104. IL-17C is required for lethal inflammation during systemic fungal infection. Cellular and Molecular Immunology. 13:474-483.
    105. Mincle activation and the Syk/Card9 signaling axis are central to the development of autoimmune disease of the eye. Journal of Immunology. 196:3148-3158.
    106. CARMA3 Is a Host Factor Regulating the Balance of Inflammatory and Antiviral Responses against Viral Infection. Cell Reports. 14:2389-2401.
    107. CARD9 knockout ameliorates myocardial dysfunction associated with high fat diet-induced obesity. Journal of Molecular and Cellular Cardiology. 92:185-195.
    108. Antifungal activity of plasmacytoid dendritic cells against Cryptococcus neoformans In Vitro requires expression of dectin-3 (CLEC4D) and reactive oxygen species. Infection and Immunity. 84:2493-2504.
    109. MALT1 is required for EGFR-induced NF-κB activation and contributes to EGFR-driven lung cancer progression. Oncogene.
    110. The CBM complex underwrites NF-κB activation to promote HER2-associated tumor malignancy. Molecular Cancer Research. 14:93-102.
    111. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 104:2024.
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