TitleAssociate Professor
InstitutionMD Anderson
Address7455 Fannin St
Houston TX 77054-1901
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70. PMID: 24777531; PMCID: PMC4032322.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    2. Puebla-Osorio N, Kim J, Ojeda S, Zhang H, Tavana O, Li S, Wang Y, Ma Q, Schluns KS, Zhu C. A novel Ku70 function in colorectal homeostasis separate from nonhomologous end joining. Oncogene. 2014 May 22; 33(21):2748-57. PMID: 23752193; PMCID: PMC5761319.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    3. Tavana O, Puebla-Osorio N, Kim J, Sang M, Jang S, Zhu C. Ku70 functions in addition to nonhomologous end joining in pancreatic ?-cells: a connection to ?-catenin regulation. Diabetes. 2013 Jul; 62(7):2429-38. PMID: 23474484; PMCID: PMC3712041.
      Citations: 9     Fields:    Translation:AnimalsCells
    4. Hu H, Brittain GC, Chang JH, Puebla-Osorio N, Jin J, Zal A, Xiao Y, Cheng X, Chang M, Fu YX, Zal T, Zhu C, Sun SC. OTUD7B controls non-canonical NF-?B activation through deubiquitination of TRAF3. Nature. 2013 Feb 21; 494(7437):371-4. PMID: 23334419; PMCID: PMC3578967.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    5. Tavana O, Zhu C. Too many breaks (brakes): pancreatic ?-cell senescence leads to diabetes. Cell Cycle. 2011 Aug 01; 10(15):2471-84. PMID: 21750406.
      Citations: 19     Fields:    Translation:HumansCells
    6. Darlington Y, Nguyen TA, Moon SH, Herron A, Rao P, Zhu C, Lu X, Donehower LA. Absence of Wip1 partially rescues Atm deficiency phenotypes in mice. Oncogene. 2012 Mar 01; 31(9):1155-65. PMID: 21765465; PMCID: PMC3197977.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Puebla-Osorio N, Miyahara Y, Coimbatore S, Kazimi N, Ullrich SE, Zhu C, Lim?n-Flores AY. Induction of B-cell lymphoma by UVB radiation in p53 haploinsufficient mice. BMC Cancer. 2011 Jan 26; 11:36. PMID: 21269511; PMCID: PMC3041776.
      Citations: 3     Fields:    Translation:Animals
    8. Tavana O, Benjamin CL, Puebla-Osorio N, Sang M, Ullrich SE, Ananthaswamy HN, Zhu C. Absence of p53-dependent apoptosis leads to UV radiation hypersensitivity, enhanced immunosuppression and cellular senescence. Cell Cycle. 2010 Aug 15; 9(16):3328-36. PMID: 20703098; PMCID: PMC3041166.
      Citations: 31     Fields:    Translation:AnimalsCells
    9. Dujka ME, Puebla-Osorio N, Tavana O, Sang M, Zhu C. ATM and p53 are essential in the cell-cycle containment of DNA breaks during V(D)J recombination in vivo. Oncogene. 2010 Feb 18; 29(7):957-65. PMID: 19915617.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    10. Tavana O, Puebla-Osorio N, Sang M, Zhu C. Absence of p53-dependent apoptosis combined with nonhomologous end-joining deficiency leads to a severe diabetic phenotype in mice. Diabetes. 2010 Jan; 59(1):135-42. PMID: 19833883; PMCID: PMC2797914.
      Citations: 28     Fields:    Translation:Animals
    11. Puebla-Osorio N, Zhu C. DNA damage and repair during lymphoid development: antigen receptor diversity, genomic integrity and lymphomagenesis. Immunol Res. 2008; 41(2):103-22. PMID: 18214391.
      Citations: 16     Fields:    Translation:AnimalsCells
    12. Van Nguyen T, Puebla-Osorio N, Pang H, Dujka ME, Zhu C. DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med. 2007 Jun 11; 204(6):1453-61. PMID: 17535972; PMCID: PMC2118600.
      Citations: 34     Fields:    Translation:Animals
    13. Yan M, Zhu C, Liu N, Jiang Y, Scofield VL, Riggs PK, Qiang W, Lynn WS, Wong PK. ATM controls c-Myc and DNA synthesis during postnatal thymocyte development through regulation of redox state. Free Radic Biol Med. 2006 Aug 15; 41(4):640-8. PMID: 16863997.
      Citations: 7     Fields:    Translation:AnimalsCells
    14. Puebla-Osorio N, Lacey DB, Alt FW, Zhu C. Early embryonic lethality due to targeted inactivation of DNA ligase III. Mol Cell Biol. 2006 May; 26(10):3935-41. PMID: 16648486; PMCID: PMC1489003.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    15. Ahkter S, Richie CT, Zhang N, Behringer RR, Zhu C, Legerski RJ. Snm1-deficient mice exhibit accelerated tumorigenesis and susceptibility to infection. Mol Cell Biol. 2005 Nov; 25(22):10071-8. PMID: 16260620; PMCID: PMC1280277.
      Citations: 23     Fields:    Translation:AnimalsCells
    16. Dudley DD, Sekiguchi J, Zhu C, Sadofsky MJ, Whitlow S, DeVido J, Monroe RJ, Bassing CH, Alt FW. Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice. J Exp Med. 2003 Nov 03; 198(9):1439-50. PMID: 14581608; PMCID: PMC2194253.
      Citations: 30     Fields:    Translation:AnimalsCells
    17. Rooney S, Sekiguchi J, Zhu C, Cheng HL, Manis J, Whitlow S, DeVido J, Foy D, Chaudhuri J, Lombard D, Alt FW. Leaky Scid phenotype associated with defective V(D)J coding end processing in Artemis-deficient mice. Mol Cell. 2002 Dec; 10(6):1379-90. PMID: 12504013.
      Citations: 116     Fields:    Translation:HumansAnimalsCells
    18. Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell. 2002 Jun 28; 109(7):811-21. PMID: 12110179.
      Citations: 191     Fields:    Translation:AnimalsCells
    19. Wong KK, Chang S, Weiler SR, Ganesan S, Chaudhuri J, Zhu C, Artandi SE, Rudolph KL, Gottlieb GJ, Chin L, Alt FW, DePinho RA. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet. 2000 Sep; 26(1):85-8. PMID: 10973255.
      Citations: 91     Fields:    Translation:AnimalsCells
    20. Frank KM, Sharpless NE, Gao Y, Sekiguchi JM, Ferguson DO, Zhu C, Manis JP, Horner J, DePinho RA, Alt FW. DNA ligase IV deficiency in mice leads to defective neurogenesis and embryonic lethality via the p53 pathway. Mol Cell. 2000 Jun; 5(6):993-1002. PMID: 10911993.
      Citations: 213     Fields:    Translation:AnimalsCells
    21. Sekiguchi JM, Gao Y, Gu Y, Frank K, Sun Y, Chaudhuri J, Zhu C, Cheng HL, Manis J, Ferguson D, Davidson L, Greenberg ME, Alt FW. Nonhomologous end-joining proteins are required for V(D)J recombination, normal growth, and neurogenesis. Cold Spring Harb Symp Quant Biol. 1999; 64:169-81. PMID: 11232282.
      Citations: 17     Fields:    Translation:AnimalsCells
    22. Gao Y, Sun Y, Frank KM, Dikkes P, Fujiwara Y, Seidl KJ, Sekiguchi JM, Rathbun GA, Swat W, Wang J, Bronson RT, Malynn BA, Bryans M, Zhu C, Chaudhuri J, Davidson L, Ferrini R, Stamato T, Orkin SH, Greenberg ME, Alt FW. A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis. Cell. 1998 Dec 23; 95(7):891-902. PMID: 9875844.
      Citations: 239     Fields:    Translation:AnimalsCells
    23. Gao Y, Chaudhuri J, Zhu C, Davidson L, Weaver DT, Alt FW. A targeted DNA-PKcs-null mutation reveals DNA-PK-independent functions for KU in V(D)J recombination. Immunity. 1998 Sep; 9(3):367-76. PMID: 9768756.
      Citations: 157     Fields:    Translation:AnimalsCells
    24. Gu Y, Seidl KJ, Rathbun GA, Zhu C, Manis JP, van der Stoep N, Davidson L, Cheng HL, Sekiguchi JM, Frank K, Stanhope-Baker P, Schlissel MS, Roth DB, Alt FW. Growth retardation and leaky SCID phenotype of Ku70-deficient mice. Immunity. 1997 Nov; 7(5):653-65. PMID: 9390689.
      Citations: 149     Fields:    Translation:AnimalsCells
    25. Bogue MA, Wang C, Zhu C, Roth DB. V(D)J recombination in Ku86-deficient mice: distinct effects on coding, signal, and hybrid joint formation. Immunity. 1997 Jul; 7(1):37-47. PMID: 9252118.
      Citations: 60     Fields:    Translation:AnimalsCells
    26. Zhu C, Bogue MA, Roth DB. Thymocyte differentiation in gamma-irradiated severe-combined immunodeficient mice: characterization of intermediates and products of V(D)J recombination at the T cell receptor alpha locus. Eur J Immunol. 1996 Dec; 26(12):2859-65. PMID: 8977278.
      Citations: 2     Fields:    Translation:Animals
    27. Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell. 1996 Aug 09; 86(3):379-89. PMID: 8756720.
      Citations: 149     Fields:    Translation:AnimalsCells
    28. Bogue MA, Zhu C, Aguilar-Cordova E, Donehower LA, Roth DB. p53 is required for both radiation-induced differentiation and rescue of V(D)J rearrangement in scid mouse thymocytes. Genes Dev. 1996 Mar 01; 10(5):553-65. PMID: 8598286.
      Citations: 30     Fields:    Translation:AnimalsCells
    29. Steen SB, Zhu C, Roth DB. Double-strand breaks, DNA hairpins, and the mechanism of V(D)J recombination. Curr Top Microbiol Immunol. 1996; 217:61-77. PMID: 8787618.
      Citations: 2     Fields:    Translation:AnimalsCells
    30. Zhu C, Roth DB. Mechanism of V(D)J recombination. Cancer Surv. 1996; 28:295-309. PMID: 8977042.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    31. Kabotyanski EB, Zhu C, Kallick DA, Roth DB. Hairpin opening by single-strand-specific nucleases. Nucleic Acids Res. 1995 Oct 11; 23(19):3872-81. PMID: 7479030; PMCID: PMC307304.
      Citations: 6     Fields:    Translation:Cells
    32. Zhu C, Roth DB. Characterization of coding ends in thymocytes of scid mice: implications for the mechanism of V(D)J recombination. Immunity. 1995 Jan; 2(1):101-12. PMID: 7600297.
      Citations: 40     Fields:    Translation:AnimalsCells
    33. Roth DB, Zhu C, Gellert M. Characterization of broken DNA molecules associated with V(D)J recombination. Proc Natl Acad Sci U S A. 1993 Nov 15; 90(22):10788-92. PMID: 8248171; PMCID: PMC47863.
      Citations: 66     Fields:    Translation:AnimalsCells
    34. Sligh JE, Hurwitz MY, Zhu CM, Anderson DC, Beaudet AL. An initiation codon mutation in CD18 in association with the moderate phenotype of leukocyte adhesion deficiency. J Biol Chem. 1992 Jan 15; 267(2):714-8. PMID: 1346132.
      Citations: 12     Fields:    Translation:HumansCells
    35. Zhu CM, Henney HR. DNA methylation pattern during the encystment of Physarum flavicomum. Biochem Cell Biol. 1990 Jun; 68(6):944-8. PMID: 2168719.
      Citations: 4     Fields:    Translation:AnimalsCells
    36. Zhu CM, Henney HR. Intracellular polyamine patterns during encystment of Physarum flavicomum. Can J Microbiol. 1990 May; 36(5):366-8. PMID: 2390746.
      Citations:    Fields:    Translation:Animals
    37. Zhu CM, Cumaraswamy A, Henney HR. Comparison of polyamine and S-adenosylmethionine contents of growing and encysted Acanthamoeba isolates. Mol Cell Biochem. 1989 Oct 31; 90(2):145-53. PMID: 2586495.
      Citations: 3     Fields:    Translation:Animals
    38. Irradiation rescue of v(d)j recombination and t cell differentiation in seid thymocytes requires p53. FASEB Journal. 10.
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