ZHIMIN LU

TitleProfessor
InstitutionMD Anderson
DepartmentNeuro-Oncology
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Qian X, Li X, Shi Z, Xia Y, Cai Q, Xu D, Tan L, Du L, Zheng Y, Zhao D, Zhang C, Lorenzi PL, You Y, Jiang BH, Jiang T, Li H, Lu Z. PTEN Suppresses Glycolysis by Dephosphorylating and Inhibiting Autophosphorylated PGK1. Mol Cell. 2019 11 07; 76(3):516-527.e7. PMID: 31492635.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    2. Xu D, Li X, Shao F, Lv G, Lv H, Lee JH, Qian X, Wang Z, Xia Y, Du L, Zheng Y, Wang H, Lyu J, Lu Z. The protein kinase activity of fructokinase A specifies the antioxidant responses of tumor cells by phosphorylating p62. Sci Adv. 2019 04; 5(4):eaav4570. PMID: 31032410.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    3. Yang P, Jiang Y, Pan Y, Ding X, Rhea P, Ding J, Hawke DH, Felsher D, Narla G, Lu Z, Lee RT. Mistletoe extract Fraxini inhibits the proliferation of liver cancer by down-regulating c-Myc expression. Sci Rep. 2019 04 23; 9(1):6428. PMID: 31015523.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    4. Li X, Qian X, Jiang H, Xia Y, Zheng Y, Li J, Huang BJ, Fang J, Qian CN, Jiang T, Zeng YX, Lu Z. Nuclear PGK1 Alleviates ADP-Dependent Inhibition of CDC7 to Promote DNA Replication. Mol Cell. 2018 11 15; 72(4):650-660.e8. PMID: 30392930.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    5. Wang Y, Xia Y, Lu Z. Metabolic features of cancer cells. Cancer Commun (Lond). 2018 10 30; 38(1):65. PMID: 30376896.
      Citations: 18     Fields:    Translation:HumansCells
    6. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2018 Oct; 20(10):1226. PMID: 29632342.
      Citations:    Fields:    
    7. Li X, Egervari G, Wang Y, Berger SL, Lu Z. Regulation of chromatin and gene expression by metabolic enzymes and metabolites. Nat Rev Mol Cell Biol. 2018 09; 19(9):563-578. PMID: 29930302.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    8. Wang Y, Guo YR, Xing D, Tao YJ, Lu Z. Supramolecular assembly of KAT2A with succinyl-CoA for histone succinylation. Cell Discov. 2018; 4:47. PMID: 30109122.
      Citations:    
    9. McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY. Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype. Cell Rep. 2018 05 15; 23(7):2095-2106. PMID: 29768207.
      Citations: 5     Fields:    Translation:HumansCells
    10. Lee JH, Liu R, Li J, Wang Y, Tan L, Li XJ, Qian X, Zhang C, Xia Y, Xu D, Guo W, Ding Z, Du L, Zheng Y, Chen Q, Lorenzi PL, Mills GB, Jiang T, Lu Z. EGFR-Phosphorylated Platelet Isoform of Phosphofructokinase 1 Promotes PI3K Activation. Mol Cell. 2018 04 19; 70(2):197-210.e7. PMID: 29677490.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    11. Lu Z, Hunter T. Metabolic Kinases Moonlighting as Protein Kinases. Trends Biochem Sci. 2018 04; 43(4):301-310. PMID: 29463470.
      Citations: 25     Fields:    Translation:HumansAnimals
    12. Wang Y, Guo YR, Liu K, Yin Z, Liu R, Xia Y, Tan L, Yang P, Lee JH, Li XJ, Hawke D, Zheng Y, Qian X, Lyu J, He J, Xing D, Tao YJ, Lu Z. KAT2A coupled with the a-KGDH complex acts as a histone H3 succinyltransferase. Nature. 2017 12 14; 552(7684):273-277. PMID: 29211711.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    13. Qian X, Li X, Tan L, Lee JH, Xia Y, Cai Q, Zheng Y, Wang H, Lorenzi PL, Lu Z. Conversion of PRPS Hexamer to Monomer by AMPK-Mediated Phosphorylation Inhibits Nucleotide Synthesis in Response to Energy Stress. Cancer Discov. 2018 01; 8(1):94-107. PMID: 29074724.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    14. Lee JH, Liu R, Li J, Zhang C, Wang Y, Cai Q, Qian X, Xia Y, Zheng Y, Piao Y, Chen Q, de Groot JF, Jiang T, Lu Z. Stabilization of phosphofructokinase 1 platelet isoform by AKT promotes tumorigenesis. Nat Commun. 2017 10 16; 8(1):949. PMID: 29038421.
      Citations: 26     Fields:    Translation:HumansCells
    15. Li X, Qian X, Lu Z. Local histone acetylation by ACSS2 promotes gene transcription for lysosomal biogenesis and autophagy. Autophagy. 2017 Oct 03; 13(10):1790-1791. PMID: 28820290.
      Citations: 6     Fields:    Translation:HumansCells
    16. Xiao GG, Wang H, Wang L, Zhang W, Gao G, Zhang X, Lee WP, Lu Z, Chen J, Gao P, Lu B, Tang KF, Shi L, Go VLW. Proceedings of the 1st International Conference for Cancer Metabolism and Therapy, October 14-17, 2016, Dalian, China. Pancreas. 2017 08; 46(7):953-963. PMID: 28697138.
      Citations:    Fields:    
    17. Li X, Yu W, Qian X, Xia Y, Zheng Y, Lee JH, Li W, Lyu J, Rao G, Zhang X, Qian CN, Rozen SG, Jiang T, Lu Z. Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy. Mol Cell. 2017 Jun 01; 66(5):684-697.e9. PMID: 28552616.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    18. Xia Y, Yang W, Fa M, Li X, Wang Y, Jiang Y, Zheng Y, Lee JH, Li J, Lu Z. RNF8 mediates histone H3 ubiquitylation and promotes glycolysis and tumorigenesis. J Exp Med. 2017 06 05; 214(6):1843-1855. PMID: 28507061.
      Citations:    Fields:    Translation:HumansCells
    19. Qian X, Li X, Lu Z. Protein kinase activity of the glycolytic enzyme PGK1 regulates autophagy to promote tumorigenesis. Autophagy. 2017 Jul 03; 13(7):1246-1247. PMID: 28486006.
      Citations: 15     Fields:    Translation:Cells
    20. Qian X, Li X, Cai Q, Zhang C, Yu Q, Jiang Y, Lee JH, Hawke D, Wang Y, Xia Y, Zheng Y, Jiang BH, Liu DX, Jiang T, Lu Z. Phosphoglycerate Kinase 1 Phosphorylates Beclin1 to Induce Autophagy. Mol Cell. 2017 Mar 02; 65(5):917-931.e6. PMID: 28238651.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    21. Li X, Qian X, Lu Z. Fructokinase A acts as a protein kinase to promote nucleotide synthesis. . 2016 10 17; 15(20):2689-90. PMID: 27356213.
      Citations:    
    22. Lee JH, Ji H, Lu Z. FAM129B activates Ras and promotes aerobic glycolysis. . 2016 06 02; 15(11):1391-2. PMID: 27111472.
      Citations:    
    23. Li X, Zheng Y, Lu Z. PGK1 is a new member of the protein kinome. . 2016 07 17; 15(14):1803-4. PMID: 27105392.
      Citations:    
    24. Li X, Qian X, Peng LX, Jiang Y, Hawke DH, Zheng Y, Xia Y, Lee JH, Cote G, Wang H, Wang L, Qian CN, Lu Z. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nat Cell Biol. 2016 05; 18(5):561-71. PMID: 27088854.
      Citations: 33     Fields:    Translation:HumansCells
    25. Zhao H, Heimberger AB, Lu Z, Wu X, Hodges TR, Song R, Shen J. Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes. Oncotarget. 2016 Apr 12; 7(15):20486-95. PMID: 26967252.
      Citations: 6     Fields:    Translation:Humans
    26. Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv. 2016 04; 2(4):e1501290. PMID: 27757426.
      Citations: 8     Fields:    Translation:HumansCells
    27. Li X, Jiang Y, Meisenhelder J, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, He J, Hunter T, Wang L, Lu Z. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Mol Cell. 2016 Mar 03; 61(5):705-719. PMID: 26942675.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    28. Shen J, Song R, Lu Z, Zhao H. Mitochondrial DNA copy number in whole blood and glioma risk: A case control study. Mol Carcinog. 2016 12; 55(12):2089-2094. PMID: 26756431.
      Citations: 4     Fields:    Translation:Humans
    29. Ji H, Lee JH, Wang Y, Pang Y, Zhang T, Xia Y, Zhong L, Lyu J, Lu Z. EGFR phosphorylates FAM129B to promote Ras activation. Proc Natl Acad Sci U S A. 2016 Jan 19; 113(3):644-9. PMID: 26721396.
      Citations: 8     Fields:    Translation:HumansCells
    30. Zheng Y, Li X, Qian X, Wang Y, Lee JH, Xia Y, Hawke DH, Zhang G, Lyu J, Lu Z. Secreted and O-GlcNAcylated MIF binds to the human EGF receptor and inhibits its activation. Nat Cell Biol. 2015 Oct; 17(10):1348-55. PMID: 26280537.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    31. Shin J, Phan L, Chen J, Lu Z, Lee MH. CSN6 positively regulates c-Jun in a MEKK1-dependent manner. . 2015; 14(19):3079-87. PMID: 26237449.
      Citations:    
    32. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2015 Sep; 17(9):1158-68. PMID: 26237645.
      Citations: 45     Fields:    Translation:HumansCells
    33. Yang W, Lu Z. Pyruvate kinase M2 at a glance. J Cell Sci. 2015 May 01; 128(9):1655-60. PMID: 25770102.
      Citations: 43     Fields:    Translation:HumansAnimals
    34. Xue J, Chen Y, Wu Y, Wang Z, Zhou A, Zhang S, Lin K, Aldape K, Majumder S, Lu Z, Huang S. Tumour suppressor TRIM33 targets nuclear ß-catenin degradation. Nat Commun. 2015 Feb 02; 6:6156. PMID: 25639486.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    35. Klein SR, Piya S, Lu Z, Xia Y, Alonso MM, White EJ, Wei J, Gomez-Manzano C, Jiang H, Fueyo J. C-Jun N-terminal kinases are required for oncolytic adenovirus-mediated autophagy. Oncogene. 2015 Oct 08; 34(41):5295-301. PMID: 25619840.
      Citations: 14     Fields:    Translation:HumansCells
    36. Jiang Y, Wang Y, Wang T, Hawke DH, Zheng Y, Li X, Zhou Q, Majumder S, Bi E, Liu DX, Huang S, Lu Z. PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells. Nat Commun. 2014 Nov 21; 5:5566. PMID: 25412762.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    37. Lin Y, Qiu Y, Xu C, Liu Q, Peng B, Kaufmann GF, Chen X, Lan B, Wei C, Lu D, Zhang Y, Guo Y, Lu Z, Jiang B, Edgington TS, Guo F. Functional role of asparaginyl endopeptidase ubiquitination by TRAF6 in tumor invasion and metastasis. J Natl Cancer Inst. 2014 Apr; 106(4):dju012. PMID: 24610907.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    38. Jiang Y, Li X, Yang W, Hawke DH, Zheng Y, Xia Y, Aldape K, Wei C, Guo F, Chen Y, Lu Z. PKM2 regulates chromosome segregation and mitosis progression of tumor cells. Mol Cell. 2014 Jan 09; 53(1):75-87. PMID: 24316223.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    39. Ji H, Lu Z. The role of protein kinase CK2 in glioblastoma development. Clin Cancer Res. 2013 Dec 01; 19(23):6335-7. PMID: 24166907.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    40. Zheng Y, Yang W, Aldape K, He J, Lu Z. Epidermal growth factor (EGF)-enhanced vascular cell adhesion molecule-1 (VCAM-1) expression promotes macrophage and glioblastoma cell interaction and tumor cell invasion. J Biol Chem. 2013 Nov 01; 288(44):31488-95. PMID: 24045955.
      Citations: 25     Fields:    Translation:HumansCells
    41. Yang W, Lu Z. Nuclear PKM2 regulates the Warburg effect. . 2013 Oct 01; 12(19):3154-8. PMID: 24013426.
      Citations:    
    42. Yang W, Lu Z. Regulation and function of pyruvate kinase M2 in cancer. Cancer Lett. 2013 Oct 10; 339(2):153-8. PMID: 23791887.
      Citations: 58     Fields:    Translation:HumansCells
    43. Xia Y, Yang W, Bu W, Ji H, Zhao X, Zheng Y, Lin X, Li Y, Lu Z. Differential regulation of c-Jun protein plays an instrumental role in chemoresistance of cancer cells. J Biol Chem. 2013 Jul 05; 288(27):19321-9. PMID: 23678002.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    44. Zheng Y, Lu Z. Regulation of tumor cell migration by protein tyrosine phosphatase (PTP)-proline-, glutamate-, serine-,and threonine-rich sequence (PEST). Chin J Cancer. 2013 Feb; 32(2):75-83. PMID: 23237212.
      Citations: 9     Fields:    Translation:HumansCells
    45. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis CA, Aldape K, Cantley LC, Lu Z. ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec; 14(12):1295-304. PMID: 23178880.
      Citations: 225     Fields:    Translation:HumansAnimalsCells
    46. He J, Xu Q, Jing Y, Agani F, Qian X, Carpenter R, Li Q, Wang XR, Peiper SS, Lu Z, Liu LZ, Jiang BH. Reactive oxygen species regulate ERBB2 and ERBB3 expression via miR-199a/125b and DNA methylation. . 2012 Dec; 13(12):1116-22. PMID: 23146892.
      Citations:    
    47. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z. EGFR-induced and PKCe monoubiquitylation-dependent NF-?B activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell. 2012 Dec 14; 48(5):771-84. PMID: 23123196.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    48. Lu Z. PKM2 functions as a histone kinase. . 2012 Nov 15; 11(22):4101-2. PMID: 23070542.
      Citations:    
    49. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Alfred Yung WK, Lu Z. PKM2 phosphorylates histone H3 and promotes gene transcription and tumorigenesis. Cell. 2012 Aug 17; 150(4):685-96. PMID: 22901803.
      Citations: 240     Fields:    Translation:HumansAnimalsCells
    50. Ji H, Ding Z, Hawke D, Xing D, Jiang BH, Mills GB, Lu Z. AKT-dependent phosphorylation of Niban regulates nucleophosmin- and MDM2-mediated p53 stability and cell apoptosis. . 2012 Jun 01; 13(6):554-60. PMID: 22510990.
      Citations:    
    51. Lu Z. Nonmetabolic functions of pyruvate kinase isoform M2 in controlling cell cycle progression and tumorigenesis. Chin J Cancer. 2012 Jan; 31(1):5-7. PMID: 22200182.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    52. Guo W, Wu S, Wang L, Wei X, Liu X, Wang J, Lu Z, Hollingshead M, Fang B. Antitumor activity of a novel oncrasin analogue is mediated by JNK activation and STAT3 inhibition. PLoS One. 2011; 6(12):e28487. PMID: 22174819.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    53. Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z. Nuclear PKM2 regulates ß-catenin transactivation upon EGFR activation. Nature. 2011 Dec 01; 480(7375):118-22. PMID: 22056988.
      Citations: 333     Fields:    Translation:HumansAnimalsCells
    54. Zheng Y, Yang W, Xia Y, Hawke D, Liu DX, Lu Z. Ras-induced and extracellular signal-regulated kinase 1 and 2 phosphorylation-dependent isomerization of protein tyrosine phosphatase (PTP)-PEST by PIN1 promotes FAK dephosphorylation by PTP-PEST. Mol Cell Biol. 2011 Nov; 31(21):4258-69. PMID: 21876001.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    55. Liu DX, Qian D, Wang B, Yang JM, Lu Z. p300-Dependent ATF5 acetylation is essential for Egr-1 gene activation and cell proliferation and survival. Mol Cell Biol. 2011 Sep; 31(18):3906-16. PMID: 21791614.
      Citations: 20     Fields:    Translation:HumansCells
    56. Badgwell DB, Lu Z, Le K, Gao F, Yang M, Suh GK, Bao JJ, Das P, Andreeff M, Chen W, Yu Y, Ahmed AA, S-L Liao W, Bast RC. The tumor-suppressor gene ARHI (DIRAS3) suppresses ovarian cancer cell migration through inhibition of the Stat3 and FAK/Rho signaling pathways. Oncogene. 2012 Jan 05; 31(1):68-79. PMID: 21643014.
      Citations: 38     Fields:    Translation:HumansCells
    57. Chiu WT, Lee HT, Huang FJ, Aldape KD, Yao J, Steeg PS, Chou CY, Lu Z, Xie K, Huang S. Caveolin-1 upregulation mediates suppression of primary breast tumor growth and brain metastases by stat3 inhibition. Cancer Res. 2011 Jul 15; 71(14):4932-43. PMID: 21622714.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    58. Ji H, Wang J, Fang B, Fang X, Lu Z. a-Catenin inhibits glioma cell migration, invasion, and proliferation by suppression of ß-catenin transactivation. J Neurooncol. 2011 Jul; 103(3):445-51. PMID: 20872274.
      Citations: 14     Fields:    Translation:HumansCells
    59. Lu Z, Hunter T. Ubiquitylation and proteasomal degradation of the p21(Cip1), p27(Kip1) and p57(Kip2) CDK inhibitors. . 2010 Jun 15; 9(12):2342-52. PMID: 20519948.
      Citations:    
    60. Ding Z, Liang J, Li J, Lu Y, Ariyaratna V, Lu Z, Davies MA, Westwick JK, Mills GB. Physical association of PDK1 with AKT1 is sufficient for pathway activation independent of membrane localization and phosphatidylinositol 3 kinase. PLoS One. 2010 Mar 26; 5(3):e9910. PMID: 20361045.
      Citations: 17     Fields:    Translation:HumansCells
    61. Ji H, Wang J, Nika H, Hawke D, Keezer S, Ge Q, Fang B, Fang X, Fang D, Litchfield DW, Aldape K, Lu Z. EGF-induced ERK activation promotes CK2-mediated disassociation of alpha-Catenin from beta-Catenin and transactivation of beta-Catenin. Mol Cell. 2009 Nov 25; 36(4):547-59. PMID: 19941816.
      Citations: 116     Fields:    Translation:HumansCells
    62. Zheng Y, Lu Z. Paradoxical roles of FAK in tumor cell migration and metastasis. . 2009 Nov 01; 8(21):3474-9. PMID: 19829089.
      Citations:    
    63. Zheng Y, Xia Y, Hawke D, Halle M, Tremblay ML, Gao X, Zhou XZ, Aldape K, Cobb MH, Xie K, He J, Lu Z. FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. Mol Cell. 2009 Jul 10; 35(1):11-25. PMID: 19595712.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    64. Chen H, Xia Y, Fang D, Hawke D, Lu Z. Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis. Mol Cell Biol. 2009 Jul; 29(13):3657-64. PMID: 19380486.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    65. Lu Z, Hunter T. Degradation of activated protein kinases by ubiquitination. Annu Rev Biochem. 2009; 78:435-75. PMID: 19489726.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    66. Liu S, Fang X, Hall H, Yu S, Smith D, Lu Z, Fang D, Liu J, Stephens LC, Woodgett JR, Mills GB. Homozygous deletion of glycogen synthase kinase 3beta bypasses senescence allowing Ras transformation of primary murine fibroblasts. Proc Natl Acad Sci U S A. 2008 Apr 01; 105(13):5248-53. PMID: 18367674.
      Citations: 9     Fields:    Translation:AnimalsCells
    67. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, Mills GB, Kobayashi R, Hunter T, Lu Z. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007 Apr 13; 282(15):11221-9. PMID: 17287208.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    68. Xia Y, Wang J, Liu TJ, Yung WK, Hunter T, Lu Z. c-Jun downregulation by HDAC3-dependent transcriptional repression promotes osmotic stress-induced cell apoptosis. Mol Cell. 2007 Jan 26; 25(2):219-32. PMID: 17244530.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    69. Xia Y, Wang J, Xu S, Johnson GL, Hunter T, Lu Z. MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress. Mol Cell Biol. 2007 Jan; 27(2):510-7. PMID: 17101801.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    70. Lu Z, Xu S. ERK1/2 MAP kinases in cell survival and apoptosis. IUBMB Life. 2006 Nov; 58(11):621-31. PMID: 17085381.
      Citations: 175     Fields:    Translation:HumansAnimalsCells
    71. Lu Z, Luo RZ, Peng H, Huang M, Nishmoto A, Hunt KK, Helin K, Liao WS, Yu Y. E2F-HDAC complexes negatively regulate the tumor suppressor gene ARHI in breast cancer. Oncogene. 2006 Jan 12; 25(2):230-9. PMID: 16158053.
      Citations: 22     Fields:    Translation:HumansCells
    72. Bast RC, Badgwell D, Lu Z, Marquez R, Rosen D, Liu J, Baggerly KA, Atkinson EN, Skates S, Zhang Z, Lokshin A, Menon U, Jacobs I, Lu K. New tumor markers: CA125 and beyond. Int J Gynecol Cancer. 2005 Nov-Dec; 15 Suppl 3:274-81. PMID: 16343244.
      Citations: 135     Fields:    Translation:Humans
    73. Lu Z, Hunter T. Wnt-independent beta-catenin transactivation in tumor development. . 2004 May; 3(5):571-3. PMID: 15107603.
      Citations:    
    74. Lu Z, Ghosh S, Wang Z, Hunter T. Downregulation of caveolin-1 function by EGF leads to the loss of E-cadherin, increased transcriptional activity of beta-catenin, and enhanced tumor cell invasion. Cancer Cell. 2003 Dec; 4(6):499-515. PMID: 14706341.
      Citations: 217     Fields:    Translation:HumansCells
    75. Lu Z, Xu S, Joazeiro C, Cobb MH, Hunter T. The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2. Mol Cell. 2002 May; 9(5):945-56. PMID: 12049732.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    76. Zhong M, Lu Z, Foster DA. Downregulating PKC delta provides a PI3K/Akt-independent survival signal that overcomes apoptotic signals generated by c-Src overexpression. Oncogene. 2002 Feb 07; 21(7):1071-8. PMID: 11850824.
      Citations: 12     Fields:    Translation:AnimalsCells
    77. Joseph T, Wooden R, Bryant A, Zhong M, Lu Z, Foster DA. Transformation of cells overexpressing a tyrosine kinase by phospholipase D1 and D2. Biochem Biophys Res Commun. 2001 Dec 21; 289(5):1019-24. PMID: 11741292.
      Citations: 29     Fields:    Translation:AnimalsCells
    78. Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001 Jul; 12(7):363-9. PMID: 11457733.
      Citations: 145     Fields:    Translation:HumansCells
    79. Lu Z, Jiang G, Blume-Jensen P, Hunter T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol. 2001 Jun; 21(12):4016-31. PMID: 11359909.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    80. Zhong M, Lu Z, Abbas T, Hornia A, Chatakondu K, Barile N, Kaplan P, Foster DA. Novel tumor-promoting property of tamoxifen. Cell Growth Differ. 2001 Apr; 12(4):187-92. PMID: 11331247.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    81. Goi T, Shipitsin M, Lu Z, Foster DA, Klinz SG, Feig LA. An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity. EMBO J. 2000 Feb 15; 19(4):623-30. PMID: 10675331.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    82. Lu Z, Hornia A, Joseph T, Sukezane T, Frankel P, Zhong M, Bychenok S, Xu L, Feig LA, Foster DA. Phospholipase D and RalA cooperate with the epidermal growth factor receptor to transform 3Y1 rat fibroblasts. Mol Cell Biol. 2000 Jan; 20(2):462-7. PMID: 10611224.
      Citations: 39     Fields:    Translation:AnimalsCells
    83. Hornia A, Lu Z, Sukezane T, Zhong M, Joseph T, Frankel P, Foster DA. Antagonistic effects of protein kinase C alpha and delta on both transformation and phospholipase D activity mediated by the epidermal growth factor receptor. Mol Cell Biol. 1999 Nov; 19(11):7672-80. PMID: 10523655.
      Citations: 21     Fields:    Translation:AnimalsCells
    84. Aguirre-Ghiso JA, Frankel P, Farias EF, Lu Z, Jiang H, Olsen A, Feig LA, de Kier Joffe EB, Foster DA. RalA requirement for v-Src- and v-Ras-induced tumorigenicity and overproduction of urokinase-type plasminogen activator: involvement of metalloproteases. Oncogene. 1999 Aug 19; 18(33):4718-25. PMID: 10467419.
      Citations: 20     Fields:    Translation:AnimalsCells
    85. Lu Z, Liu D, Hornia A, Devonish W, Pagano M, Foster DA. Activation of protein kinase C triggers its ubiquitination and degradation. Mol Cell Biol. 1998 Feb; 18(2):839-45. PMID: 9447980.
      Citations: 89     Fields:    Translation:AnimalsCells
    86. Lu Z, Hornia A, Jiang YW, Zang Q, Ohno S, Foster DA. Tumor promotion by depleting cells of protein kinase C delta. Mol Cell Biol. 1997 Jun; 17(6):3418-28. PMID: 9154841.
      Citations: 34     Fields:    Translation:AnimalsCells
    87. Zang Q, Lu Z, Curto M, Barile N, Shalloway D, Foster DA. Association between v-Src and protein kinase C delta in v-Src-transformed fibroblasts. J Biol Chem. 1997 May 16; 272(20):13275-80. PMID: 9148947.
      Citations: 20     Fields:    Translation:AnimalsCells
    88. Jiang Y, Lu Z, Zang Q, Foster DA. Regulation of phosphatidic acid phosphohydrolase by epidermal growth factor. Reduced association with the EGF receptor followed by increased association with protein kinase Cepsilon. J Biol Chem. 1996 Nov 22; 271(47):29529-32. PMID: 8939878.
      Citations: 5     Fields:    Translation:HumansCells
    89. Jiang H, Luo JQ, Urano T, Frankel P, Lu Z, Foster DA, Feig LA. Involvement of Ral GTPase in v-Src-induced phospholipase D activation. Nature. 1995 Nov 23; 378(6555):409-12. PMID: 7477381.
      Citations: 68     Fields:    Translation:AnimalsCells
    90. Jiang H, Lu Z, Luo JQ, Wolfman A, Foster DA. Ras mediates the activation of phospholipase D by v-Src. J Biol Chem. 1995 Mar 17; 270(11):6006-9. PMID: 7890731.
      Citations: 23     Fields:    Translation:AnimalsCells
    91. Fructokinase A acts as a protein kinase to promote nucleotide synthesis. Cell Cycle. 1-2.
    92. Mir-21-Sox2 axis delineates glioblastoma subtypes with prognostic impact. Journal of Neuroscience. 35:15097-15112.
    93. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nature Communications. 7.
    94. Erratum. Nature Cell Biology. 15:124.
    95. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology. 17:1158-1168.
    96. FAM129B activates Ras and promotes aerobic glycolysis. Cell Cycle. 15:1391-1392.
    97. EGFR phosphorylates FAM129B to promote Ras activation. Proceedings of the National Academy of Sciences of the United States of America. 113:644-649.
    98. Pyruvate kinase M2 at a glance. Journal of Cell Science. 128:1655-1660.
    99. Erratum. Journal of Biological Chemistry. 289:18667.
    100. Mitochondrial DNA copy number in whole blood and glioma risk. Molecular Carcinogenesis.
    101. Metabolomics profiling in plasma samples from glioma patients correlates with tumor phenotypes. Oncotarget. 7:20486-20495.
    102. A splicing switch from ketohexokinase-C to ketohexokinase-A drives hepatocellular carcinoma formation. Nature Cell Biology. 18:561-571.
    103. MEKK1. 79-87.
    104. Erratum. Cell. 158:1210.
    105. Erratum. Nature Cell Biology. 18:709.
    106. CSN6 positively regulates c-jun in a MEKK1-dependent manner. Cell Cycle. 14:3079-3087.
    107. Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. Molecular Cell. 61:705-719.
    108. PGK1 is a new member of the protein kinome. Cell Cycle. 1-2.
    109. Erratum. EMBO Reports. 15:1000.
    110. MEKK1. 79-87.
    111. Activation of Wnt signaling in tumor development. 809-822.
    112. Chemotherapy with or without autologous cytokine-induced killer cell transfusion as the first-line treatment for stage IV gastrointestinal cancer. Journal of Cancer Research and Clinical Oncology. 1-9.
    113. Prolyl isomerase Pin1 in cancer. Cell Research.
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