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KRISHNA P BHAT

TitleAssistant Professor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim SH, Joshi K, Ezhilarasan R, Myers TR, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KPL, Salcini AE, Nakano I. EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner. Stem Cell Reports. 2024 Oct 08; 19(10):1516. PMID: 39389676.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Gupta P, Dang M, Oberai S, Migliozzi S, Trivedi R, Kumar G, Peshoff M, Milam N, Ahmed A, Bojja K, Tran TM, Gumin J, Kamiya-Matsuoka C, Huse J, Cox K, Li J, Shehwana H, Sheth SA, Saxon R, Baohua S, Parker-Kerrigan B, Maheshwari A, Parra Cuentas ER, Navin NE, Heimberger AB, Lang FF, Iavarone A, Clise-Dwyer K, Wang L, Bhat KP. Immune landscape of isocitrate dehydrogenase-stratified primary and recurrent human gliomas. Neuro Oncol. 2024 Aug 10. PMID: 39126294.
      Citations: 2     Fields:    
    3. Cheng J, Li M, Motta E, Barci D, Song W, Zhou D, Li G, Zhu S, Yang A, Vaillant BD, Imhof A, Forn? I, Spiegl-Kreinecker S, Zhang N, Katayama H, Bhat KPL, Fl?h C, K?lin RE, Glass R. Myeloid cells coordinately induce glioma cell-intrinsic and cell-extrinsic pathways for chemoresistance via GP130 signaling. Cell Rep Med. 2024 Aug 20; 5(8):101658. PMID: 39053460; PMCID: PMC11384956.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Sonnemann HM, Pazdrak B, Nassif B, Sun Y, Elzohary L, Talukder AH, Katailiha AS, Bhat K, Liz?e G. Placental co-transcriptional activator Vestigial-like 1 (VGLL1) drives tumorigenesis via increasing transcription of proliferation and invasion genes. Front Oncol. 2024; 14:1403052. PMID: 38912065; PMCID: PMC11190739.
      Citations:    
    5. Dubey PK, Singh S, Khalil H, Kommini GK, Bhat KM, Krishnamurthy P. Obg-like ATPase 1 Genetic Deletion Leads to Dilated Cardiomyopathy in Mice and Structural Changes in Drosophila Heart. bioRxiv. 2024 Jun 02. PMID: 38854005; PMCID: PMC11160646.
      Citations:    
    6. Peshoff MM, Gupta P, Oberai S, Trivedi R, Katayama H, Chakrapani P, Dang M, Migliozzi S, Gumin J, Kadri DB, Lin JK, Milam NK, Maynard ME, Vaillant BD, Parker-Kerrigan B, Lang FF, Huse JT, Iavarone A, Wang L, Clise-Dwyer K, Bhat KP, Peshoff MM, Gupta P, Oberai S, Trivedi R, Katayama H, Chakrapani P, Dang M, Migliozzi S, Gumin J, Kadri DB, Lin JK, Milam NK, Maynard ME, Vaillant BD, Parker-Kerrigan B, Lang FF, Huse JT, Iavarone A, Wang L, Clise-Dwyer K, Bhat KP. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. Neuro Oncol. 2024 May 03; 26(5):826-839. PMID: 38237157; PMCID: PMC11066944.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    7. Chandra V, Li L, Le Roux O, Zhang Y, Howell RM, Rupani DN, Baydogan S, Miller HD, Riquelme E, Petrosino J, Kim MP, Bhat KPL, White JR, Kolls JK, Pylayeva-Gupta Y, McAllister F. Gut epithelial Interleukin-17 receptor A signaling can modulate distant tumors growth through microbial regulation. Cancer Cell. 2024 01 08; 42(1):85-100.e6. PMID: 38157865; PMCID: PMC11238637.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Trivedi R, Bhat KP. Liquid biopsy: creating opportunities in brain space. Br J Cancer. 2023 11; 129(11):1727-1746. PMID: 37752289; PMCID: PMC10667495.
      Citations: 1     Fields:    Translation:HumansCells
    9. Venkadakrishnan J, Lahane G, Dhar A, Xiao W, Bhat KM, Pandita TK, Bhat A. Implications of Translesion DNA Synthesis Polymerases on Genomic Stability and Human Health. Mol Cell Biol. 2023; 43(8):401-425. PMID: 37439479; PMCID: PMC10448981.
      Citations:    Fields:    Translation:HumansCells
    10. Chu Y, Dai E, Li Y, Han G, Pei G, Ingram DR, Thakkar K, Qin JJ, Dang M, Le X, Hu C, Deng Q, Sinjab A, Gupta P, Wang R, Hao D, Peng F, Yan X, Liu Y, Song S, Zhang S, Heymach JV, Reuben A, Elamin YY, Pizzi MP, Lu Y, Lazcano R, Hu J, Li M, Curran M, Futreal A, Maitra A, Jazaeri AA, Ajani JA, Swanton C, Cheng XD, Abbas HA, Gillison M, Bhat K, Lazar AJ, Green M, Litchfield K, Kadara H, Yee C, Wang L. Pan-cancer T cell atlas links a cellular stress response state to immunotherapy resistance. Nat Med. 2023 Jun; 29(6):1550-1562. PMID: 37248301; PMCID: PMC11421770.
      Citations: 26     Fields:    Translation:HumansCells
    11. Peshoff MM, Gupta P, Trivedi R, Oberai S, Chakrapani P, Dang M, Milam N, Maynard ME, Vaillant BD, Huse JT, Wang L, Clise-Dwyer K, Bhat KP. Triggering receptor expressed on myeloid cells 2 (TREM2) regulates phagocytosis in glioblastoma. bioRxiv. 2023 Apr 06. PMID: 37066184; PMCID: PMC10104029.
      Citations:    
    12. Jahedi A, Kumar G, Kannan L, Agarwal T, Huse J, Bhat K, Kannan K. Gibbs process distinguishes survival and reveals contact-inhibition genes in Glioblastoma multiforme. PLoS One. 2023; 18(2):e0277176. PMID: 36795646; PMCID: PMC9934342.
      Citations:    Fields:    Translation:HumansCells
    13. Modrek AS, Eskilsson E, Ezhilarasan R, Wang Q, Goodman LD, Ding Y, Zhang ZY, Bhat KPL, Le TT, Barthel FP, Tang M, Yang J, Long L, Gumin J, Lang FF, Verhaak RGW, Aldape KD, Sulman EP. PDPN marks a subset of aggressive and radiation-resistant glioblastoma cells. Front Oncol. 2022; 12:941657. PMID: 36059614; PMCID: PMC9434399.
      Citations:    
    14. Myers JL, Porter M, Narwold N, Bhat K, Dauwalder B, Roman G. Mutants of the white ABCG Transporter in Drosophila melanogaster Have Deficient Olfactory Learning and Cholesterol Homeostasis. Int J Mol Sci. 2021 Nov 30; 22(23). PMID: 34884779; PMCID: PMC8657504.
      Citations: 2     Fields:    Translation:AnimalsCells
    15. Pudakalakatti S, Audia A, Mukhopadhyay A, Enriquez JS, Bourgeois D, Tayob N, Zacharias NM, Millward SW, Carson D, Farach-Carson MC, Lang FF, Heimberger AB, Bhat KP, Bhattacharya PK. NMR Spectroscopy-Based Metabolomics of Platelets to Analyze Brain Tumors. Reports (MDPI). 2021 Dec; 4(4). PMID: 35937580; PMCID: PMC9352435.
      Citations:    
    16. Han G, Yang G, Hao D, Lu Y, Thein K, Simpson BS, Chen J, Sun R, Alhalabi O, Wang R, Dang M, Dai E, Zhang S, Nie F, Zhao S, Guo C, Hamza A, Czerniak B, Cheng C, Siefker-Radtke A, Bhat K, Futreal A, Peng G, Wargo J, Peng W, Kadara H, Ajani J, Swanton C, Litchfield K, Ahnert JR, Gao J, Wang L. 9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy. Nat Commun. 2021 09 23; 12(1):5606. PMID: 34556668; PMCID: PMC8460828.
      Citations: 13     Fields:    Translation:HumansCells
    17. Banday S, Pandita RK, Mushtaq A, Bacolla A, Mir US, Singh DK, Jan S, Bhat KP, Hunt CR, Rao G, Charaka VK, Tainer JA, Pandita TK, Altaf M. Autism-Associated Vigilin Depletion Impairs DNA Damage Repair. Mol Cell Biol. 2021 06 23; 41(7):e0008221. PMID: 33941620; PMCID: PMC8224237.
      Citations: 3     Fields:    Translation:HumansCells
    18. Valdebenito S, Audia A, Bhat KPL, Okafo G, Eugenin EA. Tunneling Nanotubes Mediate Adaptation of Glioblastoma Cells to Temozolomide and Ionizing Radiation Treatment. iScience. 2020 Sep 25; 23(9):101450. PMID: 32882515; PMCID: PMC7476317.
      Citations: 12     
    19. Balasubramaniyan V, Bhat K. Targeting pyrimidine metabolism for glioblastoma therapy. Neuro Oncol. 2020 02 20; 22(2):169-170. PMID: 31863119; PMCID: PMC7032621.
      Citations: 1     Fields:    Translation:Humans
    20. Wei J, Chen P, Gupta P, Ott M, Zamler D, Kassab C, Bhat KP, Curran MA, de Groot JF, Heimberger AB. Immune biology of glioma-associated macrophages and microglia: functional and therapeutic implications. Neuro Oncol. 2020 02 20; 22(2):180-194. PMID: 31679017; PMCID: PMC7442334.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    21. Yamashita D, Bernstock JD, Elsayed G, Sadahiro H, Mohyeldin A, Chagoya G, Ilyas A, Mooney J, Estevez-Ordonez D, Yamaguchi S, Flanary VL, Hackney JR, Bhat KP, Kornblum HI, Zamboni N, Kim SH, Chiocca EA, Nakano I. Targeting glioma-initiating cells via the tyrosine metabolic pathway. J Neurosurg. 2021 03 01; 134(3):721-732. PMID: 32059178; PMCID: PMC8447888.
      Citations: 6     Fields:    Translation:HumansCells
    22. Lowe S, Bhat KP, Olar A. Current clinical management of patients with glioblastoma. Cancer Rep (Hoboken). 2019 12; 2(6):e1216. PMID: 32721125; PMCID: PMC7941570.
      Citations: 5     Fields:    Translation:HumansAnimals
    23. Day BW, Lathia JD, Bruce ZC, D'Souza RCJ, Baumgartner U, Ensbey KS, Lim YC, Stringer BW, Li Y, Jamieson PR, Smith FM, Jurd CLR, Robertson T, Inglis PL, Lwin Z, Jeffree RL, Johns TG, Bhat KPL, Rich JN, Campbell KP, Boyd AW, Akg?l S, Offenh?user C. The dystroglycan receptor maintains glioma stem cells in the vascular niche. Acta Neuropathol. 2019 12; 138(6):1033-1052. PMID: 31463571; PMCID: PMC6851226.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    24. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y, Koo H, Snigdha K, Waghmare I, Guo X, Mohyeldin A, Gallego-Perez D, Wang J, Chen D, Cheng P, Mukheef F, Contreras M, Reyes JF, Vaillant B, Sulman EP, Cheng SY, Markert JM, Tannous BA, Lu X, Kango-Singh M, Lee LJ, Nam DH, Nakano I, Bhat KP. Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation. Cell Rep. 2019 02 12; 26(7):1893-1905.e7. PMID: 30759398; PMCID: PMC6594377.
      Citations: 69     Fields:    Translation:Humans
    25. D'Angelo F, Ceccarelli M, Garofano L, Zhang J, Caruso FP, Lewis G, Alfaro KD, Bauchet L, Cachia D, Cangiano M, de Groot J, DiMeco F, Farah W, Finocchiaro G, Kamiya-Matsuoka C, Loiseau H, McCutcheon I, Nam DH, Saletti V, Slopis J, Vandenbos F, Varlet P, Watts C, Tabar V, Reuss DE, Kim SK, Meyronet D, Bhat KP, Eoli M, Lasorella A, Iavarone A, Frattini V, Berzero G, Capelle L, Ducray F, Goutagny S, Lavarino C, Lorgis V, Marras CE, Ronchi S, Seizeur R, Su?ol M, Vidaud D, Mokhtari K, Salvador H, Sanson M. The molecular landscape of glioma in patients with Neurofibromatosis 1. Nat Med. 2019 01; 25(1):176-187. PMID: 30531922; PMCID: PMC6857804.
      Citations: 66     Fields:    Translation:HumansCells
    26. Conroy S, Kruyt FAE, Wagemakers M, Bhat KPL, den Dunnen WFA. IL-8 associates with a pro-angiogenic and mesenchymal subtype in glioblastoma. Oncotarget. 2018 Mar 20; 9(21):15721-15731. PMID: 29644004; PMCID: PMC5884659.
      Citations: 16     Fields:    
    27. Audia A, Bhat KP. Ritanserin, a novel agent targeting the mesenchymal subtype of glioblastomas. Neuro Oncol. 2018 01 22; 20(2):151-152. PMID: 29365204; PMCID: PMC5786216.
      Citations: 1     Fields:    Translation:Humans
    28. Boyd NH, Walker K, Fried J, Hackney JR, McDonald PC, Benavides GA, Spina R, Audia A, Scott SE, Landis CJ, Tran AN, Bevensee MO, Griguer C, Nozell S, Gillespie GY, Nabors B, Bhat KP, Bar EE, Darley-Usmar V, Xu B, Gordon E, Cooper SJ, Dedhar S, Hjelmeland AB. Addition of carbonic anhydrase 9 inhibitor SLC-0111 to temozolomide treatment delays glioblastoma growth in vivo. JCI Insight. 2017 12 21; 2(24). PMID: 29263302; PMCID: PMC5752277.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    29. Moreno M, Pedrosa L, Pineda E, Bejarano L, Balasubramaniyan V, Ezhilarasan R, Kallarackal N, Kim SH, Wang J, Audia A, Conroy S, Marin M, Ribalta T, Pujol T, Herreros A, Alonso MM, Graus F, Sulman EP, Piao X, Nakano I, Prat A, Bhat KP, Par? L, Mart?nez J, Tortosa A, Mira H, G?mez-Manzano C, de la Iglesia N. GPR56/ADGRG1 Inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma. Cell Rep. 2017 Nov 21; 21(8):2183-2197. PMID: 29166609.
      Citations: 29     Fields:    Translation:HumansCells
    30. Boonyawan K, Hess KR, Yang J, Long L, Wang Q, Ezhilarasan R, Auia A, Alfaro-Munoz KD, de Groot JF, Bhat KP, Sulman EP. A relative increase in circulating platelets following chemoradiation predicts for poor survival of patients with glioblastoma. Oncotarget. 2017 Oct 27; 8(52):90488-90495. PMID: 29163847; PMCID: PMC5685768.
      Citations: 7     Fields:    
    31. Balasubramaniyan V, Bhat KP. Targeting MIR155HG in glioma: a novel approach. Neuro Oncol. 2017 09 01; 19(9):1152-1153. PMID: 28821207; PMCID: PMC5570169.
      Citations: 4     Fields:    Translation:Humans
    32. Li M, Xiao A, Floyd D, Olmez I, Lee J, Godlewski J, Bronisz A, Bhat KPL, Sulman EP, Nakano I, Purow B. CDK4/6 inhibition is more active against the glioblastoma proneural subtype. Oncotarget. 2017 Aug 15; 8(33):55319-55331. PMID: 28903422; PMCID: PMC5589661.
      Citations: 18     Fields:    
    33. Audia A, Conroy S, Glass R, Bhat KPL. The Impact of the Tumor Microenvironment on the Properties of Glioma Stem-Like Cells. Front Oncol. 2017; 7:143. PMID: 28740831; PMCID: PMC5502267.
      Citations: 30     
    34. Cheng P, Wang J, Waghmare I, Sartini S, Coviello V, Zhang Z, Kim SH, Mohyeldin A, Pavlyukov MS, Minata M, Valentim CL, Chhipa RR, Bhat KP, Dasgupta B, La Motta C, Kango-Singh M, Nakano I. FOXD1-ALDH1A3 Signaling Is a Determinant for the Self-Renewal and Tumorigenicity of Mesenchymal Glioma Stem Cells. Cancer Res. 2016 12 15; 76(24):7219-7230. PMID: 27569208; PMCID: PMC5161538.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    35. Gabrusiewicz K, Rodriguez B, Wei J, Hashimoto Y, Healy LM, Maiti SN, Thomas G, Zhou S, Wang Q, Elakkad A, Liebelt BD, Yaghi NK, Ezhilarasan R, Huang N, Weinberg JS, Prabhu SS, Rao G, Sawaya R, Langford LA, Bruner JM, Fuller GN, Bar-Or A, Li W, Colen RR, Curran MA, Bhat KP, Antel JP, Cooper LJ, Sulman EP, Heimberger AB. Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype. JCI Insight. 2016; 1(2). PMID: 26973881; PMCID: PMC4784261.
      Citations: 194     Fields:    
    36. Kim SH, Ezhilarasan R, Phillips E, Gallego-Perez D, Sparks A, Taylor D, Ladner K, Furuta T, Sabit H, Chhipa R, Cho JH, Mohyeldin A, Beck S, Kurozumi K, Kuroiwa T, Iwata R, Asai A, Kim J, Sulman EP, Cheng SY, Lee LJ, Nakada M, Guttridge D, DasGupta B, Goidts V, Bhat KP, Nakano I. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-?B-dependent Manner. Cancer Cell. 2016 Feb 08; 29(2):201-13. PMID: 26859459; PMCID: PMC4837946.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    37. Sathyan P, Zinn PO, Marisetty AL, Liu B, Kamal MM, Singh SK, Bady P, Lu L, Wani KM, Veo BL, Gumin J, Kassem DH, Robinson F, Weng C, Baladandayuthapani V, Suki D, Colman H, Bhat KP, Sulman EP, Aldape K, Colen RR, Verhaak RG, Lu Z, Fuller GN, Huang S, Lang FF, Sawaya R, Hegi M, Majumder S. Mir-21-Sox2 Axis Delineates Glioblastoma Subtypes with Prognostic Impact. J Neurosci. 2015 Nov 11; 35(45):15097-112. PMID: 26558781; PMCID: PMC4642241.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    38. Balasubramaniyan V, Vaillant B, Wang S, Gumin J, Butalid ME, Sai K, Mukheef F, Kim SH, Boddeke HW, Lang F, Aldape K, Sulman EP, Bhat KP, Colman H. Aberrant mesenchymal differentiation of glioma stem-like cells: implications for therapeutic targeting. Oncotarget. 2015 Oct 13; 6(31):31007-17. PMID: 26307681; PMCID: PMC4741584.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    39. Kim SH, Joshi K, Ezhilarasan R, Siu J, Gu C, Nakano-Okuno M, Taylor D, Minata M, Sulman EP, Lee J, Bhat KP, Nakano I, Myers TR, Salcini AE. EZH2 protects glioma stem cells from radiation-induced cell death in a MELK/FOXM1-dependent manner. Stem Cell Reports. 2015 Feb 10; 4(2):226-38. PMID: 25601206; PMCID: PMC4325196.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    40. Conroy S, Kruyt FA, Joseph JV, Balasubramaniyan V, Bhat KP, Wagemakers M, Enting RH, Walenkamp AM, den Dunnen WF. Subclassification of newly diagnosed glioblastomas through an immunohistochemical approach. PLoS One. 2014; 9(12):e115687. PMID: 25546404; PMCID: PMC4278713.
      Citations: 13     Fields:    Translation:HumansCells
    41. Zadeh G, Bhat KP, Aldape K. EGFR and EGFRvIII in glioblastoma: partners in crime. Cancer Cell. 2013 Oct 14; 24(4):403-4. PMID: 24135276.
      Citations: 24     Fields:    Translation:Humans
    42. Bhat KPL, Balasubramaniyan V, Vaillant B, Ezhilarasan R, Hummelink K, Hollingsworth F, Wani K, Heathcock L, James JD, Goodman LD, Conroy S, Long L, Lelic N, Wang S, Gumin J, Raj D, Kodama Y, Raghunathan A, Olar A, Joshi K, Pelloski CE, Heimberger A, Kim SH, Cahill DP, Rao G, Den Dunnen WFA, Boddeke HWGM, Phillips HS, Nakano I, Lang FF, Colman H, Sulman EP, Aldape K. Mesenchymal differentiation mediated by NF-?B promotes radiation resistance in glioblastoma. Cancer Cell. 2013 Sep 09; 24(3):331-46. PMID: 23993863; PMCID: PMC3817560.
      Citations: 479     Fields:    Translation:HumansAnimalsCells
    43. Poddighe S, Bhat KM, Setzu MD, Solla P, Angioy AM, Marotta R, Ruffilli R, Marrosu F, Liscia A. Impaired sense of smell in a Drosophila Parkinson's model. PLoS One. 2013; 8(8):e73156. PMID: 24009736; PMCID: PMC3757021.
      Citations: 15     Fields:    Translation:AnimalsCells
    44. Bhat KP, Aldape K. Not expecting the unexpected: diacylglycerol kinase alpha as a cancer target. Cancer Discov. 2013 Jul; 3(7):726-7. PMID: 23847350.
      Citations:    Fields:    Translation:HumansAnimals
    45. Doucette TA, Kong LY, Yang Y, Ferguson SD, Yang J, Wei J, Qiao W, Fuller GN, Bhat KP, Aldape K, Priebe W, Heimberger AB, Rao G, B?gler O. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol. 2012 Sep; 14(9):1136-45. PMID: 22753228; PMCID: PMC3424209.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    46. Bhat KP, Salazar KL, Balasubramaniyan V, Wani K, Heathcock L, Hollingsworth F, James JD, Gumin J, Diefes KL, Kim SH, Turski A, Azodi Y, Yang Y, Doucette T, Colman H, Sulman EP, Lang FF, Rao G, Copray S, Vaillant BD, Aldape KD. The transcriptional coactivator TAZ regulates mesenchymal differentiation in malignant glioma. Genes Dev. 2011 Dec 15; 25(24):2594-609. PMID: 22190458; PMCID: PMC3248681.
      Citations: 203     Fields:    Translation:HumansAnimalsCells
    47. Zhu Z, Bhat KM. The Drosophila Hem/Kette/Nap1 protein regulates asymmetric division of neural precursor cells by regulating localization of Inscuteable and Numb. Mech Dev. 2011 Sep-Dec; 128(7-10):483-95. PMID: 21996673; PMCID: PMC3263386.
      Citations: 4     Fields:    Translation:AnimalsCells
    48. Hafer N, Xu S, Bhat KM, Schedl P. The Drosophila CPEB protein Orb2 has a novel expression pattern and is important for asymmetric cell division and nervous system function. Genetics. 2011 Nov; 189(3):907-21. PMID: 21900268; PMCID: PMC3213381.
      Citations: 19     Fields:    Translation:AnimalsCells
    49. Zhu Z, Bhat KM. The Hem protein mediates neuronal migration by inhibiting WAVE degradation and functions opposite of Abelson tyrosine kinase. Dev Biol. 2011 Sep 15; 357(2):283-94. PMID: 21726548; PMCID: PMC3218108.
      Citations: 2     Fields:    Translation:AnimalsCells
    50. Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011 Aug; 13(8):894-903. PMID: 21653597; PMCID: PMC3145466.
      Citations: 63     Fields:    Translation:HumansCells
    51. Gu D, Tonthat NK, Lee M, Ji H, Bhat KP, Hollingsworth F, Aldape KD, Schumacher MA, Zwaka TP, McCrea PD. Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. J Biol Chem. 2011 Jul 01; 286(26):23178-88. PMID: 21561870; PMCID: PMC3123085.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    52. Macias E, Jin A, Deisenroth C, Bhat K, Mao H, Zhang Y, Lindstr?m MS. An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. Cancer Cell. 2010 Sep 14; 18(3):231-43. PMID: 20832751; PMCID: PMC4400806.
      Citations: 109     Fields:    Translation:HumansAnimalsCells
    53. Noushmehr H, Weisenberger DJ, Diefes K, Phillips HS, Pujara K, Berman BP, Pan F, Pelloski CE, Sulman EP, Bhat KP, Verhaak RG, Hoadley KA, Hayes DN, Perou CM, Schmidt HK, Ding L, Wilson RK, Van Den Berg D, Shen H, Bengtsson H, Neuvial P, Cope LM, Buckley J, Herman JG, Baylin SB, Laird PW, Aldape K, Cancer Genome Atlas Research Network. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010 May 18; 17(5):510-22. PMID: 20399149; PMCID: PMC2872684.
      Citations: 1124     Fields:    Translation:HumansCells
    54. Colman H, Zhang L, Sulman EP, McDonald JM, Shooshtari NL, Rivera A, Popoff S, Nutt CL, Louis DN, Cairncross JG, Gilbert MR, Phillips HS, Mehta MP, Chakravarti A, Pelloski CE, Bhat K, Feuerstein BG, Jenkins RB, Aldape K. A multigene predictor of outcome in glioblastoma. Neuro Oncol. 2010 Jan; 12(1):49-57. PMID: 20150367; PMCID: PMC2940562.
      Citations: 184     Fields:    Translation:Humans
    55. Gazi M, Shyamala BV, Bhat KM. A neurodegenerative disease affecting synaptic connections in Drosophila mutant for the tumor suppressor morphogen Patched. Dev Biol. 2009 Oct 01; 334(1):311-23. PMID: 19635474; PMCID: PMC2760493.
      Citations: 4     Fields:    Translation:AnimalsCells
    56. Martin V, Xu J, Pabbisetty SK, Alonso MM, Liu D, Lee OH, Gumin J, Bhat KP, Colman H, Lang FF, Fueyo J, Gomez-Manzano C. Tie2-mediated multidrug resistance in malignant gliomas is associated with upregulation of ABC transporters. Oncogene. 2009 Jun 18; 28(24):2358-63. PMID: 19421150; PMCID: PMC3431162.
      Citations: 21     Fields:    Translation:HumansCells
    57. Bhat KP, Pelloski CE, Zhang Y, Kim SH, deLaCruz C, Rehli M, Aldape KD. Selective repression of YKL-40 by NF-kappaB in glioma cell lines involves recruitment of histone deacetylase-1 and -2. FEBS Lett. 2008 Sep 22; 582(21-22):3193-200. PMID: 18708058.
      Citations: 26     Fields:    Translation:HumansCells
    58. Itahana K, Mao H, Jin A, Itahana Y, Clegg HV, Bhat KP, Godfrey VL, Evan GI, Zhang Y, Lindstr?m MS. Targeted inactivation of Mdm2 RING finger E3 ubiquitin ligase activity in the mouse reveals mechanistic insights into p53 regulation. Cancer Cell. 2007 Oct; 12(4):355-66. PMID: 17936560.
      Citations: 139     Fields:    Translation:AnimalsCells
    59. Pelloski CE, Ballman KV, Furth AF, Zhang L, Lin E, Sulman EP, Bhat K, McDonald JM, Yung WK, Colman H, Woo SY, Heimberger AB, Suki D, Prados MD, Chang SM, Barker FG, Buckner JC, James CD, Aldape K. Epidermal growth factor receptor variant III status defines clinically distinct subtypes of glioblastoma. J Clin Oncol. 2007 Jun 01; 25(16):2288-94. PMID: 17538175.
      Citations: 121     Fields:    Translation:Humans
    60. Koul D, Shen R, Shishodia S, Takada Y, Bhat KP, Reddy SA, Aggarwal BB, Yung WK. PTEN down regulates AP-1 and targets c-fos in human glioma cells via PI3-kinase/Akt pathway. Mol Cell Biochem. 2007 Jun; 300(1-2):77-87. PMID: 17235455.
      Citations: 14     Fields:    Translation:HumansCells
    61. Dugan SA, Bhat KP. Biomechanics and analysis of running gait. Phys Med Rehabil Clin N Am. 2005 Aug; 16(3):603-21. PMID: 16005396.
      Citations: 29     Fields:    Translation:Humans
    62. Merianda TT, Botta V, Bhat KM. Patched regulation of axon guidance is by specifying neural identity in the Drosophila nerve cord. Dev Genes Evol. 2005 Jun; 215(6):285-96. PMID: 15754211.
      Citations: 4     Fields:    Translation:AnimalsCells
    63. Kinghorn AD, Su BN, Jang DS, Chang LC, Lee D, Gu JQ, Carcache-Blanco EJ, Pawlus AD, Lee SK, Park EJ, Cuendet M, Gills JJ, Bhat K, Park HS, Mata-Greenwood E, Song LL, Jang M, Pezzuto JM. Natural inhibitors of carcinogenesis. Planta Med. 2004 Aug; 70(8):691-705. PMID: 15326546.
      Citations: 31     Fields:    Translation:HumansAnimals
    64. Bhat KP, Itahana K, Jin A, Zhang Y. Essential role of ribosomal protein L11 in mediating growth inhibition-induced p53 activation. EMBO J. 2004 Jun 16; 23(12):2402-12. PMID: 15152193; PMCID: PMC423289.
      Citations: 138     Fields:    Translation:HumansCells
    65. Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA, Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53-dependent ribosomal-stress checkpoint pathway. Mol Cell Biol. 2003 Dec; 23(23):8902-12. PMID: 14612427; PMCID: PMC262682.
      Citations: 288     Fields:    Translation:HumansCells
    66. Itahana K, Bhat KP, Jin A, Itahana Y, Hawke D, Kobayashi R, Zhang Y. Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation. Mol Cell. 2003 Nov; 12(5):1151-64. PMID: 14636574.
      Citations: 199     Fields:    Translation:HumansCells
    67. Bhat KP, Pezzuto JM. Cancer chemopreventive activity of resveratrol. Ann N Y Acad Sci. 2002 May; 957:210-29. PMID: 12074974.
      Citations: 99     Fields:    Translation:HumansAnimals
    68. Burdette JE, Liu J, Lantvit D, Lim E, Booth N, Bhat KP, Hedayat S, Van Breemen RB, Constantinou AI, Pezzuto JM, Farnsworth NR, Bolton JL. Trifolium pratense (red clover) exhibits estrogenic effects in vivo in ovariectomized Sprague-Dawley rats. J Nutr. 2002 Jan; 132(1):27-30. PMID: 11773503.
      Citations: 20     Fields:    Translation:Animals
    69. Bhat KP, Pezzuto JM. Natural modulators of estrogen biosynthesis and function as chemopreventive agents. Arch Pharm Res. 2001 Dec; 24(6):473-84. PMID: 11794520.
      Citations: 5     Fields:    Translation:Humans
    70. Kosmeder JW, Pezzuto JM. Biological effects of resveratrol. Antioxid Redox Signal. 2001 Dec; 3(6):1041-64. PMID: 11813979.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    71. Bhat KP, Lantvit D, Christov K, Mehta RG, Moon RC, Pezzuto JM. Estrogenic and antiestrogenic properties of resveratrol in mammary tumor models. Cancer Res. 2001 Oct 15; 61(20):7456-63. PMID: 11606380.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    72. Lee D, Bhat KP, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD. Aromatase inhibitors from Broussonetia papyrifera. J Nat Prod. 2001 Oct; 64(10):1286-93. PMID: 11678652.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    73. Bhat KP, Pezzuto JM. Resveratrol exhibits cytostatic and antiestrogenic properties with human endometrial adenocarcinoma (Ishikawa) cells. Cancer Res. 2001 Aug 15; 61(16):6137-44. PMID: 11507064.
      Citations: 19     Fields:    Translation:HumansCells
    74. Mehta RG, Bhat KP, Hawthorne ME, Kopelovich L, Mehta RR, Christov K, Kelloff GJ, Steele VE, Pezzuto JM. Induction of atypical ductal hyperplasia in mouse mammary gland organ culture. J Natl Cancer Inst. 2001 Jul 18; 93(14):1103-6. PMID: 11459872.
      Citations: 6     Fields:    Translation:Animals
    75. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, Farnsworth NR, Bolton JL. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem. 2001 May; 49(5):2472-9. PMID: 11368622.
      Citations: 86     Fields:    Translation:HumansCells
    76. Chang LC, Gills JJ, Bhat KP, Luyengi L, Farnsworth NR, Pezzuto JM, Kinghorn AD. Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. Bioorg Med Chem Lett. 2000 Nov 06; 10(21):2431-4. PMID: 11078194.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    77. Kim DS, Jeong HJ, Bhat KP, Park SY, Kang SH, Yoo EH, Lee M, Lee HW, Krueger RJ. Aromatase and sulfatase inhibitors from Lepiota americana. Planta Med. 2000 Feb; 66(1):78-9. PMID: 10705743.
      Citations:    Fields:    Translation:AnimalsCells
    78. Kook Lee S, Bhat KP, Lee K, Chai HB, Kristinsson H, Song LL, Gills J, Mata-Greenwood E, Jang MS, Pezzuto JM, Ing?lfsd?ttir K, Gudmundsd?ttir JT. Evaluation of selected lichens from iceland for cancer chemopreventive and cytotoxic activity. Pharm Biol. 2000; 38(4):313-7. PMID: 21214483.
      Citations: 1     Fields:    
    79. Chang LC, Bhat KP, Pisha E, Kennelly EJ, Fong HH, Pezzuto JM, Kinghorn AD. Activity-guided isolation of steroidal alkaloid antiestrogen-binding site inhibitors from Pachysandra procumbens. J Nat Prod. 1998 Oct; 61(10):1257-62. PMID: 9784163.
      Citations: 7     Fields:    Translation:AnimalsCells
    80. Mir-21-Sox2 axis delineates glioblastoma subtypes with prognostic impact. Journal of Neuroscience. 35:15097-15112.
    81. Novel bioactive steroidal alkaloids from Pachysandra procumbens. Tetrahedron. 56:3133-3138.
    82. FOXD1-ALDH1A3 signaling is a determinant for the self-renewal and tumorigenicity of mesenchymal glioma stem cells. Cancer Research. 76:7219-7230.
    83. Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner. Cancer Cell. 29:201-213.
    84. Aberrant mesenchymal differentiation of glioma stem-like cells. Oncotarget. 6:31007-31017.
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